TMEM204

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: C16ORF30 plays a role in cell adhesion and cellular permeability at adherens junctions (Kearsey et al., 2004 [PubMed 15206924]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)6.66282563
2vascular endothelial growth factor signaling pathway (GO:0038084)6.45961226
3* lymph vessel development (GO:0001945)6.02204304
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.96428819
5positive regulation of vasculogenesis (GO:2001214)5.77189090
6negative regulation of cell killing (GO:0031342)5.76492416
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.76492416
8lymphangiogenesis (GO:0001946)5.60234572
9regulation of endothelial cell differentiation (GO:0045601)5.57476638
10surfactant homeostasis (GO:0043129)5.47232544
11retina vasculature morphogenesis in camera-type eye (GO:0061299)5.41826285
12cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.33997708
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.24923829
14regulation of vasculogenesis (GO:2001212)5.22411961
15blood vessel maturation (GO:0001955)5.14342423
16antigen processing and presentation of endogenous antigen (GO:0019883)4.87578442
17morphogenesis of an endothelium (GO:0003159)4.75931774
18endothelial tube morphogenesis (GO:0061154)4.75931774
19positive regulation of gamma-delta T cell activation (GO:0046645)4.62082182
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.55697224
21positive regulation of endothelial cell differentiation (GO:0045603)4.48578145
22endothelial cell differentiation (GO:0045446)4.33073120
23chemical homeostasis within a tissue (GO:0048875)4.31490617
24regulation of gamma-delta T cell differentiation (GO:0045586)4.18326168
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.17776778
26transcytosis (GO:0045056)4.12762613
27negative T cell selection (GO:0043383)4.10638991
28negative thymic T cell selection (GO:0045060)4.07702314
29vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.01671780
30regulation of gamma-delta T cell activation (GO:0046643)3.88449286
31regulation of B cell receptor signaling pathway (GO:0050855)3.85452695
32patterning of blood vessels (GO:0001569)3.78953996
33basement membrane organization (GO:0071711)3.71728700
34heart trabecula formation (GO:0060347)3.70568491
35tolerance induction (GO:0002507)3.69821596
36regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.68275878
37leukocyte aggregation (GO:0070486)3.65379489
38response to interleukin-15 (GO:0070672)3.65150127
39positive thymic T cell selection (GO:0045059)3.63813022
40endothelial cell morphogenesis (GO:0001886)3.63067209
41negative regulation of blood vessel endothelial cell migration (GO:0043537)3.58922151
42endothelial cell chemotaxis (GO:0035767)3.56050490
43regulation of T cell tolerance induction (GO:0002664)3.54775900
44ovulation from ovarian follicle (GO:0001542)3.49816551
45thymic T cell selection (GO:0045061)3.49601266
46blood vessel endothelial cell migration (GO:0043534)3.44748700
47cellular response to interleukin-15 (GO:0071350)3.42858493
48sprouting angiogenesis (GO:0002040)3.39639433
49negative regulation of stress fiber assembly (GO:0051497)3.39635905
50T cell migration (GO:0072678)3.39089584
51venous blood vessel morphogenesis (GO:0048845)3.37844582
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.36492128
53glomerular filtration (GO:0003094)3.36381108
54cell migration involved in sprouting angiogenesis (GO:0002042)3.35187397
55vasculogenesis (GO:0001570)3.34168440
56positive regulation of smooth muscle cell migration (GO:0014911)3.33430641
57T cell selection (GO:0045058)3.32250775
58negative regulation of endothelial cell migration (GO:0010596)3.31852878
59positive T cell selection (GO:0043368)3.31615652
60renal filtration (GO:0097205)3.24649447
61regulation of T cell mediated cytotoxicity (GO:0001914)3.23785509
62regulation of regulatory T cell differentiation (GO:0045589)3.22661401
63positive regulation of T cell mediated cytotoxicity (GO:0001916)3.21308977
64blood vessel remodeling (GO:0001974)3.21122883
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.20244222
66peptidyl-tyrosine autophosphorylation (GO:0038083)3.17954105
67angiogenesis involved in wound healing (GO:0060055)3.17569503
68lung vasculature development (GO:0060426)3.17454906
69positive regulation of tolerance induction (GO:0002645)3.16489666
70positive regulation of granulocyte differentiation (GO:0030854)3.15262744
71negative regulation of endothelial cell proliferation (GO:0001937)3.13904978
72glomerular basement membrane development (GO:0032836)3.10315448
73negative regulation of erythrocyte differentiation (GO:0045647)3.08498250
74regulation of platelet aggregation (GO:0090330)3.08136843
75regulation of tolerance induction (GO:0002643)3.07553479
76negative regulation of endothelial cell apoptotic process (GO:2000352)3.06568584
77cellular extravasation (GO:0045123)3.04347852
78negative regulation of platelet activation (GO:0010544)3.03572158
79embryonic heart tube development (GO:0035050)3.02196539
80artery development (GO:0060840)2.99662393
81negative regulation of leukocyte mediated immunity (GO:0002704)2.98933850
82detection of bacterium (GO:0016045)2.97890536
83adhesion of symbiont to host (GO:0044406)2.97690918
84coronary vasculature morphogenesis (GO:0060977)2.96277240
85negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.95328546
86negative regulation of T-helper cell differentiation (GO:0045623)2.95328546
87cell adhesion mediated by integrin (GO:0033627)2.95217597
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95025906
89glomerular visceral epithelial cell development (GO:0072015)2.93147241
90negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.92888566
91antigen processing and presentation via MHC class Ib (GO:0002475)2.92059773
92detection of other organism (GO:0098543)2.91712372
93sodium-independent organic anion transport (GO:0043252)2.91527386
94negative regulation of Rho protein signal transduction (GO:0035024)2.91461808
95neutrophil activation involved in immune response (GO:0002283)2.91302159
96positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.90048771
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88839098
98modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88839098
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.88839098
100modulation by symbiont of host immune response (GO:0052553)2.88839098
101positive regulation by symbiont of host defense response (GO:0052509)2.88839098
102modulation by symbiont of host defense response (GO:0052031)2.88839098
103regulation of alpha-beta T cell proliferation (GO:0046640)2.88185118
104endothelial cell proliferation (GO:0001935)2.85901705
105negative regulation of blood coagulation (GO:0030195)2.84076061
106negative regulation of hemostasis (GO:1900047)2.84076061
107negative regulation of innate immune response (GO:0045824)2.83342558
108regulation of endothelial cell apoptotic process (GO:2000351)2.82885209
109negative regulation of T cell mediated immunity (GO:0002710)2.82511862
110regulation of natural killer cell mediated immunity (GO:0002715)2.81220207
111regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81220207
112regulation of complement activation (GO:0030449)2.76434664
113negative regulation of vascular permeability (GO:0043116)2.74420519
114negative regulation of phagocytosis (GO:0050765)2.74021975
115endothelial cell migration (GO:0043542)2.73769018
116regulation of endothelial cell migration (GO:0010594)2.73712499
117cardiac myofibril assembly (GO:0055003)2.72439807
118positive regulation of cell junction assembly (GO:1901890)2.70143466
119positive regulation of focal adhesion assembly (GO:0051894)2.70143466
120cellular response to type I interferon (GO:0071357)2.69586038
121type I interferon signaling pathway (GO:0060337)2.69586038
122response to type I interferon (GO:0034340)2.69314606
123negative regulation of epithelial cell migration (GO:0010633)2.69210922
124positive regulation of endothelial cell proliferation (GO:0001938)2.68128797
125regulation of protein activation cascade (GO:2000257)2.67891612
126negative regulation of actin filament bundle assembly (GO:0032232)2.64564327
127negative regulation of coagulation (GO:0050819)2.63965771
128regulation of leukocyte mediated cytotoxicity (GO:0001910)2.62794281
129cell migration involved in heart development (GO:0060973)2.62431636
130regulation of dendritic cell antigen processing and presentation (GO:0002604)2.60988248
131regulation of granulocyte differentiation (GO:0030852)2.60860741
132T cell receptor signaling pathway (GO:0050852)2.60468902
133negative regulation of nitric-oxide synthase activity (GO:0051001)2.60086624
134glomerular epithelial cell development (GO:0072310)2.59503226
135positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.58103155
136cAMP biosynthetic process (GO:0006171)2.58066682
137regulation of endothelial cell proliferation (GO:0001936)2.55674513
138regulation of blood vessel endothelial cell migration (GO:0043535)2.55385242
139* regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.55052386
140substrate-dependent cell migration (GO:0006929)2.55012675
141regulation of B cell differentiation (GO:0045577)2.54971830
142trabecula formation (GO:0060343)2.54449606
143blood vessel morphogenesis (GO:0048514)2.54299434
144negative regulation of T cell apoptotic process (GO:0070233)2.54250939
145dendritic cell chemotaxis (GO:0002407)2.54159529
146response to muramyl dipeptide (GO:0032495)2.52932084
147leukocyte migration involved in inflammatory response (GO:0002523)2.52333709
148positive regulation of natural killer cell differentiation (GO:0032825)2.51829332
149negative regulation of alpha-beta T cell activation (GO:0046636)2.51806548
150positive regulation of endothelial cell migration (GO:0010595)2.50726997
151lymph node development (GO:0048535)2.49900498
152atrioventricular valve morphogenesis (GO:0003181)2.49771135
153gap junction assembly (GO:0016264)2.49524401
154positive regulation of B cell differentiation (GO:0045579)2.49177763
155phagocytosis, recognition (GO:0006910)2.49129620
156arginine catabolic process (GO:0006527)2.49000623
157dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48992511
158establishment of endothelial barrier (GO:0061028)2.48991708
159neutrophil activation (GO:0042119)2.47835286
160antigen receptor-mediated signaling pathway (GO:0050851)2.46000038
161glomerulus development (GO:0032835)2.45532870
162negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.44824160
163potassium ion import (GO:0010107)2.44589969
164lymphocyte migration (GO:0072676)2.44585030
165positive regulation of adherens junction organization (GO:1903393)2.44474679
166B cell receptor signaling pathway (GO:0050853)2.44379691
167Arp2/3 complex-mediated actin nucleation (GO:0034314)2.42878115
168fatty acid transmembrane transport (GO:1902001)2.42689140
169Notch signaling involved in heart development (GO:0061314)2.42521119
170negative regulation of angiogenesis (GO:0016525)2.42360073
171regulation of actin filament-based movement (GO:1903115)2.41653728
172mast cell activation (GO:0045576)2.41361727
173regulation of p38MAPK cascade (GO:1900744)2.40336856
174negative regulation of blood vessel morphogenesis (GO:2000181)2.39918953
175toxin metabolic process (GO:0009404)2.39209395
176negative regulation of type 2 immune response (GO:0002829)2.39151853
177activated T cell proliferation (GO:0050798)2.38744289
178regulation of vascular permeability (GO:0043114)2.38372486
179peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.37863564
180negative regulation of wound healing (GO:0061045)2.37181923
181artery morphogenesis (GO:0048844)2.37127856
182dendritic cell migration (GO:0036336)2.36837807
183fibril organization (GO:0097435)2.36599369
184ovulation (GO:0030728)2.35777561
185response to fluid shear stress (GO:0034405)2.35474546
186positive regulation of interleukin-4 production (GO:0032753)2.34830402
187positive regulation of macrophage differentiation (GO:0045651)2.32960477
188regulation of T-helper 2 cell differentiation (GO:0045628)2.32565617
189lymphocyte chemotaxis (GO:0048247)2.32161937
190detection of external biotic stimulus (GO:0098581)2.31982693
191regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.30739812
192regulation of cell killing (GO:0031341)2.29995094
193regulation of extracellular matrix disassembly (GO:0010715)2.29793101
194signal complex assembly (GO:0007172)2.29105881
195negative regulation of cytokine production involved in immune response (GO:0002719)2.26531067
196positive regulation of cell killing (GO:0031343)2.25770885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.25377126
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.92442369
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.78142610
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.35203672
5CLOCK_20551151_ChIP-Seq_293T_Human3.27819633
6GATA1_22025678_ChIP-Seq_K562_Human2.98611500
7GATA2_21666600_ChIP-Seq_HMVEC_Human2.93679365
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.64813668
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63274786
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.58827123
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52184927
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.44019232
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.38418385
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.32993081
15SCL_19346495_ChIP-Seq_HPC-7_Human2.31611697
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.27731724
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22878455
18MAF_26560356_Chip-Seq_TH1_Human2.12194406
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.11807199
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.09685794
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.09605578
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.07655435
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02752869
24UTX_26944678_Chip-Seq_JUKART_Human2.01340520
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94880597
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.94347885
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93775879
28MYB_26560356_Chip-Seq_TH2_Human1.92434574
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.91104795
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91062345
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.86678761
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.83316807
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81822399
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81115507
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81107685
36TCF7_22412390_ChIP-Seq_EML_Mouse1.80862445
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.80842393
38* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79262508
39VDR_24763502_ChIP-Seq_THP-1_Human1.77541459
40KDM2B_26808549_Chip-Seq_DND41_Human1.74686191
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73975397
42SPI1_23127762_ChIP-Seq_K562_Human1.73642081
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.73077832
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.73077832
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71885958
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71659742
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70976281
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.70612783
49VDR_21846776_ChIP-Seq_THP-1_Human1.70086507
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69182809
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68257987
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.68200086
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.65848703
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63308194
55* MAF_26560356_Chip-Seq_TH2_Human1.62940295
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62518795
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.62449845
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59990179
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59534056
60* MYB_26560356_Chip-Seq_TH1_Human1.58526986
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58127567
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58007960
63* LXR_22292898_ChIP-Seq_THP-1_Human1.57992314
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56413067
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56228178
66MYC_22102868_ChIP-Seq_BL_Human1.55456281
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54770009
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53439484
69* CJUN_26792858_Chip-Seq_BT549_Human1.51379624
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50868795
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50858907
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47767144
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.47624436
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47383140
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.46991798
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45167055
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44750199
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41815992
79GATA3_27048872_Chip-Seq_THYMUS_Human1.41510922
80GATA1_19941826_ChIP-Seq_K562_Human1.41296856
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38972831
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.37195688
83SOX2_20726797_ChIP-Seq_SW620_Human1.37145844
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36842101
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33906415
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33537438
87ZNF263_19887448_ChIP-Seq_K562_Human1.33486550
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33225742
89* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31539167
90SPI1_23547873_ChIP-Seq_NB4_Human1.29794768
91EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25007173
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25007173
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23392147
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22908827
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22041489
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22041489
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20177774
98STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19513414
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19478137
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19474894
101SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19240590
102EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19120489
103AHR_22903824_ChIP-Seq_MCF-7_Human1.18627714
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18459465
105SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17792032
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.17091573
107CDX2_20551321_ChIP-Seq_CACO-2_Human1.16818997
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16243868
109FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15899493
110* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15775141
111VDR_24787735_ChIP-Seq_THP-1_Human1.14491820
112HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14261722
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14239276
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13295349
115GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12073782
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12025922
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11987144
118BCL6_27268052_Chip-Seq_Bcells_Human1.11335154
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08026472
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07250999
121* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07150649
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05967134
123STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05925855
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03695554
125BCAT_22108803_ChIP-Seq_LS180_Human1.03375933
126* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03319464
127JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03143773
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.02265785
129* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00357683
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00190169
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.99125872
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98986732
133KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98986732
134KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98986732
135PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98356840
136* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97513560
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96640559
138FOXA2_19822575_ChIP-Seq_HepG2_Human0.96118819
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.95780669
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95139300
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94877223
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94668668
143GATA2_19941826_ChIP-Seq_K562_Human0.94373104
144SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92457483
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91793877
146SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91045986
147GATA3_26560356_Chip-Seq_TH2_Human0.90979656
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90932947
149* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90911416
150PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90524038
151ELF1_20517297_ChIP-Seq_JURKAT_Human0.88744444
152JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88509749
153RACK7_27058665_Chip-Seq_MCF-7_Human0.88395635
154CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87699804
155BCOR_27268052_Chip-Seq_Bcells_Human0.87163985
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86922367
157WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85741118
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85355137
159SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84021254
160TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83838376
161* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83530510
162ISL1_27105846_Chip-Seq_CPCs_Mouse0.83418865
163PIAS1_25552417_ChIP-Seq_VCAP_Human0.83343025
164DROSHA_22980978_ChIP-Seq_HELA_Human0.82794048
165SMAD3_21741376_ChIP-Seq_HESCs_Human0.82653411
166KDM2B_26808549_Chip-Seq_K562_Human0.82585313
167CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82508680
168PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82002862
169RUNX_20019798_ChIP-Seq_JUKART_Human0.81749068
170TP53_18474530_ChIP-ChIP_U2OS_Human0.80740833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.99710051
2* MP0001879_abnormal_lymphatic_vessel4.80776290
3MP0005167_abnormal_blood-brain_barrier4.78681456
4MP0004272_abnormal_basement_membrane3.80347523
5MP0003724_increased_susceptibility_to3.35277703
6MP0003436_decreased_susceptibility_to3.16745885
7MP0004084_abnormal_cardiac_muscle3.02373859
8MP0003763_abnormal_thymus_physiology2.95159355
9MP0000465_gastrointestinal_hemorrhage2.85263217
10MP0003828_pulmonary_edema2.78686846
11MP0005464_abnormal_platelet_physiology2.77635700
12MP0006054_spinal_hemorrhage2.54123024
13MP0005671_abnormal_response_to2.44887157
14MP0002138_abnormal_hepatobiliary_system2.43824037
15MP0004215_abnormal_myocardial_fiber2.31171677
16MP0006138_congestive_heart_failure2.30741888
17MP0008438_abnormal_cutaneous_collagen2.26786161
18MP0001835_abnormal_antigen_presentation2.22118891
19MP0005000_abnormal_immune_tolerance2.17737497
20MP0003279_aneurysm2.13901479
21MP0000767_abnormal_smooth_muscle2.11369176
22MP0002933_joint_inflammation2.08174915
23MP0001800_abnormal_humoral_immune2.06243888
24MP0001533_abnormal_skeleton_physiology2.03801663
25MP0004036_abnormal_muscle_relaxation2.02828821
26MP0005360_urolithiasis2.02134958
27MP0005025_abnormal_response_to2.00789955
28MP0000685_abnormal_immune_system1.98327673
29MP0001958_emphysema1.96436940
30MP0002837_dystrophic_cardiac_calcinosis1.94415086
31MP0005387_immune_system_phenotype1.93657766
32MP0001790_abnormal_immune_system1.93657766
33MP0002419_abnormal_innate_immunity1.93225420
34MP0003191_abnormal_cellular_cholesterol1.92534458
35MP0002723_abnormal_immune_serum1.89801423
36MP0002420_abnormal_adaptive_immunity1.85913603
37MP0001819_abnormal_immune_cell1.83620371
38MP0005330_cardiomyopathy1.80595360
39MP0004147_increased_porphyrin_level1.80277698
40MP0002295_abnormal_pulmonary_circulatio1.79678649
41MP0009785_altered_susceptibility_to1.73486886
42MP0005165_increased_susceptibility_to1.72888953
43MP0002452_abnormal_antigen_presenting1.71886533
44MP0004484_altered_response_of1.71693808
45MP0005085_abnormal_gallbladder_physiolo1.71278013
46MP0005595_abnormal_vascular_smooth1.71216241
47MP0005670_abnormal_white_adipose1.69375948
48MP0000249_abnormal_blood_vessel1.68561479
49MP0002972_abnormal_cardiac_muscle1.68194417
50MP0002148_abnormal_hypersensitivity_rea1.67021648
51MP0005385_cardiovascular_system_phenoty1.63111776
52MP0001544_abnormal_cardiovascular_syste1.63111776
53MP0009333_abnormal_splenocyte_physiolog1.62644559
54MP0004883_abnormal_blood_vessel1.62277129
55MP0000013_abnormal_adipose_tissue1.59604642
56MP0002127_abnormal_cardiovascular_syste1.58226197
57MP0005164_abnormal_response_to1.57334708
58MP0002405_respiratory_system_inflammati1.56577257
59MP0008775_abnormal_heart_ventricle1.56408685
60MP0010155_abnormal_intestine_physiology1.55646902
61MP0002398_abnormal_bone_marrow1.52097339
62MP0005623_abnormal_meninges_morphology1.51897140
63MP0002332_abnormal_exercise_endurance1.51360654
64MP0006082_CNS_inflammation1.50669753
65MP0000343_altered_response_to1.50623442
66MP0005084_abnormal_gallbladder_morpholo1.48379879
67MP0000751_myopathy1.48108184
68MP0003705_abnormal_hypodermis_morpholog1.45354733
69MP0002139_abnormal_hepatobiliary_system1.44796644
70MP0005503_abnormal_tendon_morphology1.43018290
71MP0008875_abnormal_xenobiotic_pharmacok1.41971489
72MP0005620_abnormal_muscle_contractility1.41666284
73MP0010630_abnormal_cardiac_muscle1.40490346
74MP0004130_abnormal_muscle_cell1.40401494
75MP0000716_abnormal_immune_system1.40238409
76MP0002128_abnormal_blood_circulation1.39652782
77MP0003866_abnormal_defecation1.39506525
78MP0004947_skin_inflammation1.38942356
79MP0009379_abnormal_foot_pigmentation1.35103376
80MP0004085_abnormal_heartbeat1.32909676
81MP0003252_abnormal_bile_duct1.31477306
82MP0005390_skeleton_phenotype1.31469904
83MP0000230_abnormal_systemic_arterial1.31130062
84MP0002998_abnormal_bone_remodeling1.30569270
85MP0005275_abnormal_skin_tensile1.30467694
86MP0000703_abnormal_thymus_morphology1.28291619
87MP0008004_abnormal_stomach_pH1.26982520
88MP0004381_abnormal_hair_follicle1.26247242
89MP0009697_abnormal_copulation1.25679364
90MP0000749_muscle_degeneration1.25062511
91MP0004782_abnormal_surfactant_physiolog1.24852153
92MP0004510_myositis1.23283200
93MP0002009_preneoplasia1.22560053
94MP0002722_abnormal_immune_system1.20988042
95MP0001845_abnormal_inflammatory_respons1.18839722
96MP0005365_abnormal_bile_salt1.17398490
97MP0000689_abnormal_spleen_morphology1.16836110
98MP0003950_abnormal_plasma_membrane1.16273022
99MP0001614_abnormal_blood_vessel1.15419253
100MP0008260_abnormal_autophagy1.13338080
101MP0003566_abnormal_cell_adhesion1.12796087
102MP0002429_abnormal_blood_cell1.12266696
103MP0002925_abnormal_cardiovascular_devel1.12106468
104MP0000858_altered_metastatic_potential1.12024505
105MP0002132_abnormal_respiratory_system1.11557517
106MP0010329_abnormal_lipoprotein_level1.09364484
107MP0004087_abnormal_muscle_fiber1.04666941
108MP0009384_cardiac_valve_regurgitation1.00527574
109MP0009840_abnormal_foam_cell0.98814432
110MP0005083_abnormal_biliary_tract0.97392969
111MP0001542_abnormal_bone_strength0.91257487
112MP0002108_abnormal_muscle_morphology0.90799378
113MP0003448_altered_tumor_morphology0.90599922
114MP0002133_abnormal_respiratory_system0.90426468
115MP0005388_respiratory_system_phenotype0.90426468
116MP0000750_abnormal_muscle_regeneration0.90002147
117MP0009643_abnormal_urine_homeostasis0.89359515
118MP0005058_abnormal_lysosome_morphology0.89188453
119MP0005332_abnormal_amino_acid0.88315939
120MP0008469_abnormal_protein_level0.88269990
121MP0005397_hematopoietic_system_phenotyp0.87779561
122MP0001545_abnormal_hematopoietic_system0.87779561
123MP0003303_peritoneal_inflammation0.87559163
124MP0003300_gastrointestinal_ulcer0.87467816
125MP0000266_abnormal_heart_morphology0.87429947
126MP0005666_abnormal_adipose_tissue0.85901974
127MP0001873_stomach_inflammation0.83972661
128MP0005409_darkened_coat_color0.81728387
129MP0002396_abnormal_hematopoietic_system0.80644177
130MP0005075_abnormal_melanosome_morpholog0.80545076
131MP0003091_abnormal_cell_migration0.79376688
132MP0009278_abnormal_bone_marrow0.78857054
133MP0001851_eye_inflammation0.77406065
134MP0000003_abnormal_adipose_tissue0.77370298
135MP0009763_increased_sensitivity_to0.77334035
136MP0009764_decreased_sensitivity_to0.75460692
137MP0005375_adipose_tissue_phenotype0.74410772
138MP0001756_abnormal_urination0.72599146
139MP0003690_abnormal_glial_cell0.72072646
140MP0005171_absent_coat_pigmentation0.71147546
141MP0001915_intracranial_hemorrhage0.70420956
142MP0002254_reproductive_system_inflammat0.69458075
143MP0003137_abnormal_impulse_conducting0.69100031
144MP0003075_altered_response_to0.66766181
145MP0001784_abnormal_fluid_regulation0.65661210
146MP0004019_abnormal_vitamin_homeostasis0.65070124
147MP0005319_abnormal_enzyme/_coenzyme0.64587408
148MP0003943_abnormal_hepatobiliary_system0.63805743
149MP0002118_abnormal_lipid_homeostasis0.62538151
150MP0003638_abnormal_response/metabolism_0.62455730
151MP0004185_abnormal_adipocyte_glucose0.62409142
152MP0002166_altered_tumor_susceptibility0.62035452
153MP0002136_abnormal_kidney_physiology0.61875358
154MP0003045_fibrosis0.60605819
155MP0005023_abnormal_wound_healing0.60578193

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)6.11668589
2Hematochezia (HP:0002573)5.57579235
3Spontaneous hematomas (HP:0007420)5.29331428
4Eczematoid dermatitis (HP:0000976)4.79185052
5Prolonged bleeding time (HP:0003010)4.68026561
6Esophageal varix (HP:0002040)4.50522263
7Stomatitis (HP:0010280)4.33589926
8Elevated erythrocyte sedimentation rate (HP:0003565)4.24739937
9Broad metatarsal (HP:0001783)4.22752815
10Myositis (HP:0100614)4.07958269
11Deep venous thrombosis (HP:0002625)4.04114911
12Cerebral hemorrhage (HP:0001342)3.77420753
13Ventricular tachycardia (HP:0004756)3.66282088
14Visceral angiomatosis (HP:0100761)3.51206525
15Abnormality of the nasal mucosa (HP:0000433)3.48740219
16Epistaxis (HP:0000421)3.46363601
17Nonimmune hydrops fetalis (HP:0001790)3.43082587
18Purpura (HP:0000979)3.41329734
19Muscle fiber splitting (HP:0003555)3.40619388
20Hemangiomatosis (HP:0007461)3.40526266
21Orchitis (HP:0100796)3.39876689
22Sudden death (HP:0001699)3.38997594
23Lymphangioma (HP:0100764)3.38455499
24Conjunctival telangiectasia (HP:0000524)3.26436978
25Abnormal platelet volume (HP:0011876)3.21094968
26Gastrointestinal infarctions (HP:0005244)3.09857101
27Menorrhagia (HP:0000132)3.09697252
28Abnormality of macrophages (HP:0004311)3.07869554
29Optic neuritis (HP:0100653)3.07423432
30Retrobulbar optic neuritis (HP:0100654)3.07423432
31Increased connective tissue (HP:0009025)3.04845204
32T lymphocytopenia (HP:0005403)3.03572879
33Cerebral aneurysm (HP:0004944)3.02235017
34Atrial fibrillation (HP:0005110)3.02105318
35Petechiae (HP:0000967)2.98995317
36Short hallux (HP:0010109)2.97130221
37Hypoglycemic coma (HP:0001325)2.97008630
38Increased IgE level (HP:0003212)2.95732348
39Aortic aneurysm (HP:0004942)2.94558215
40Abnormality of the vasculature of the conjunctiva (HP:0008054)2.86400405
41Complement deficiency (HP:0004431)2.84637378
42Cavernous hemangioma (HP:0001048)2.80095649
43Increased mean platelet volume (HP:0011877)2.78745338
44Type 1 muscle fiber predominance (HP:0003803)2.77059495
45Portal hypertension (HP:0001409)2.76531692
46Abnormality of T cell number (HP:0011839)2.75719411
47Primary atrial arrhythmia (HP:0001692)2.75527415
48Supraventricular arrhythmia (HP:0005115)2.74940149
49Mesangial abnormality (HP:0001966)2.74101943
50Aplasia/Hypoplasia of the hallux (HP:0008362)2.72845661
51Recurrent fungal infections (HP:0002841)2.68957979
52Pulmonary artery stenosis (HP:0004415)2.65059752
53Lipoatrophy (HP:0100578)2.64797812
54Gingival bleeding (HP:0000225)2.64547102
55Pustule (HP:0200039)2.62768909
56Exercise-induced muscle cramps (HP:0003710)2.62514898
57Recurrent abscess formation (HP:0002722)2.62286882
58Supraventricular tachycardia (HP:0004755)2.60020395
59Dilatation of the ascending aorta (HP:0005111)2.58964189
60Congenital, generalized hypertrichosis (HP:0004540)2.57701115
61Peritonitis (HP:0002586)2.56256971
62Right ventricular cardiomyopathy (HP:0011663)2.55869332
63Hyperactive renin-angiotensin system (HP:0000841)2.55535100
64Hyporeflexia of lower limbs (HP:0002600)2.51760703
65Aortic dissection (HP:0002647)2.48506241
66Vascular tortuosity (HP:0004948)2.48410585
67Absent hand (HP:0004050)2.47485011
68Obstructive lung disease (HP:0006536)2.44830665
69Chronic obstructive pulmonary disease (HP:0006510)2.44830665
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.43723418
71Hypoalphalipoproteinemia (HP:0003233)2.43047291
72Abnormality of the hepatic vasculature (HP:0006707)2.42141343
73Mucosal telangiectasiae (HP:0100579)2.41494743
74Vasculitis (HP:0002633)2.40856065
75Recurrent gram-negative bacterial infections (HP:0005420)2.40833431
76Hypokalemic alkalosis (HP:0001949)2.39638295
77Meningitis (HP:0001287)2.38973204
78Venous insufficiency (HP:0005293)2.35955826
79Keratoconjunctivitis sicca (HP:0001097)2.35438479
80Cellulitis (HP:0100658)2.33696770
81Arterial tortuosity (HP:0005116)2.33559992
82Adactyly (HP:0009776)2.32343529
83Aneurysm (HP:0002617)2.31757282
84Pulmonary infiltrates (HP:0002113)2.30427342
85Encephalitis (HP:0002383)2.29007314
86Episodic fever (HP:0001954)2.28137631
87Chest pain (HP:0100749)2.27152328
88Asymmetric septal hypertrophy (HP:0001670)2.27114855
89Keratoconjunctivitis (HP:0001096)2.26284892
90Recurrent bacterial skin infections (HP:0005406)2.26170554
91Hemoptysis (HP:0002105)2.25989754
92Abnormality of T cells (HP:0002843)2.25987238
93Nephritis (HP:0000123)2.25211497
94Protrusio acetabuli (HP:0003179)2.25059515
95Leukocytosis (HP:0001974)2.24518622
96Increased variability in muscle fiber diameter (HP:0003557)2.22580153
97Chondrocalcinosis (HP:0000934)2.21813043
98Gastrointestinal inflammation (HP:0004386)2.21806568
99Emphysema (HP:0002097)2.21217847
100Pulmonary hypertension (HP:0002092)2.20951762
101Spondylolisthesis (HP:0003302)2.20520430
102Venous abnormality (HP:0002624)2.20469182
103Granulocytopenia (HP:0001913)2.18791622
104Panhypogammaglobulinemia (HP:0003139)2.18591579
105Mediastinal lymphadenopathy (HP:0100721)2.18363544
106Abnormality of skeletal muscle fiber size (HP:0012084)2.18003396
107Calf muscle hypertrophy (HP:0008981)2.17564039
108Growth hormone excess (HP:0000845)2.17334915
109Difficulty running (HP:0009046)2.16771017
110EMG: myopathic abnormalities (HP:0003458)2.16456994
111Inflammation of the large intestine (HP:0002037)2.16454609
112Intrahepatic cholestasis (HP:0001406)2.16378936
113Hyperlipoproteinemia (HP:0010980)2.15784656
114Dilated cardiomyopathy (HP:0001644)2.15120489
115Abnormality of Sharpey fibers (HP:0100685)2.13129689
116Ketoacidosis (HP:0001993)2.11652146
117Stroke (HP:0001297)2.11151060
118Gingivitis (HP:0000230)2.10442796
119Joint swelling (HP:0001386)2.09819221
120Xanthomatosis (HP:0000991)2.09561703
121Amyloidosis (HP:0011034)2.08163398
122Microcytic anemia (HP:0001935)2.06456226
123Exercise-induced myalgia (HP:0003738)2.05337325
124Increased IgM level (HP:0003496)2.04604829
125Spinal rigidity (HP:0003306)2.03397072
126Joint hemorrhage (HP:0005261)2.02502835
127Recurrent bronchitis (HP:0002837)2.02129479
128Pancreatic islet-cell hyperplasia (HP:0004510)2.01570573
129Absent toe (HP:0010760)2.01347997
130Premature rupture of membranes (HP:0001788)2.01235635
131Facial diplegia (HP:0001349)2.01029841
132Slender build (HP:0001533)2.00185423
133Myoglobinuria (HP:0002913)2.00076449
134Eosinophilia (HP:0001880)1.99934547
135Arterial thrombosis (HP:0004420)1.99761354
136Gastrointestinal stroma tumor (HP:0100723)1.99290497
137Joint stiffness (HP:0001387)1.98924503
138Mitral stenosis (HP:0001718)1.97517228
139Bone cyst (HP:0012062)1.96703752
140Vertebral compression fractures (HP:0002953)1.96628401
141Hemorrhage of the eye (HP:0011885)1.95914685
142Prolonged partial thromboplastin time (HP:0003645)1.95793352
143Abnormality of the calf musculature (HP:0001430)1.94948975
144Abnormal platelet function (HP:0011869)1.94917824
145Impaired platelet aggregation (HP:0003540)1.94917824
146Hypoplasia of the iris (HP:0007676)1.94884972
147Acanthosis nigricans (HP:0000956)1.93874914
148Lymphopenia (HP:0001888)1.93459963
149Systemic lupus erythematosus (HP:0002725)1.93373404
150Abnormality of complement system (HP:0005339)1.93242751
151Hypergammaglobulinemia (HP:0010702)1.93134112
152Round ear (HP:0100830)1.92764432
153Distal lower limb muscle weakness (HP:0009053)1.92336095
154Muscle hypertrophy of the lower extremities (HP:0008968)1.90601762
155Bruising susceptibility (HP:0000978)1.90342709
156Interstitial pulmonary disease (HP:0006530)1.90133669
157Pulmonary embolism (HP:0002204)1.89998999
158Glomerulonephritis (HP:0000099)1.89935726
159Abnormality of fatty-acid metabolism (HP:0004359)1.89165889
160Autoimmune hemolytic anemia (HP:0001890)1.87316907
161Hypoplastic ischia (HP:0003175)1.86593368
162Abnormality of the intrinsic pathway (HP:0010989)1.84710495
163Papilloma (HP:0012740)1.84397477
164Verrucae (HP:0200043)1.84397477
165Colitis (HP:0002583)1.82660350
166Hypertriglyceridemia (HP:0002155)1.82016777
167Cardiomegaly (HP:0001640)1.81973930
168Abnormality of the sella turcica (HP:0002679)1.80321439
169Potter facies (HP:0002009)1.80291478
170Facial shape deformation (HP:0011334)1.80291478
171Ketosis (HP:0001946)1.80246310
172Striae distensae (HP:0001065)1.80233605
173Dysostosis multiplex (HP:0000943)1.79248019
174Abnormality of eosinophils (HP:0001879)1.78022012
175Chronic mucocutaneous candidiasis (HP:0002728)1.77946250
176Recurrent cutaneous fungal infections (HP:0011370)1.77946250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.11211967
2KDR5.97944492
3TGFBR24.93328013
4MAP4K14.00230349
5MYLK2.77158132
6PDK22.54723494
7TGFBR12.49358851
8GRK62.42638312
9RIPK42.38892911
10ZAP702.31893257
11TXK2.13478579
12PTK2B2.05831802
13PRPF4B1.98091261
14GRK11.97400988
15BTK1.88850303
16EPHB21.88214980
17ERN11.83435272
18TAOK31.80511630
19TNK21.71378256
20TTN1.67461477
21JAK31.67287321
22HCK1.53484264
23MAPK151.49150403
24RIPK11.46699346
25DMPK1.45078727
26PDGFRA1.41753271
27SYK1.41346586
28PIK3CG1.41167744
29AKT31.38367487
30MAP3K131.35899433
31WNK41.35086482
32TESK21.30318653
33MAPK121.28702893
34LCK1.27040602
35FGFR41.26938048
36INSRR1.23995945
37BLK1.23964012
38FER1.23013266
39PTK61.22738494
40MAP2K31.12890721
41BCKDK1.11224653
42PHKG21.10871567
43PHKG11.10871567
44TRIB31.10598017
45IRAK41.10512568
46SIK31.07853324
47LYN1.03250430
48MAP3K31.00068851
49PRKG20.98910823
50MAPK70.98729981
51PRKD10.98370960
52LMTK20.97428326
53MAP3K140.97207896
54NUAK10.94721145
55MARK20.93812688
56BMX0.93704689
57EPHB10.91625944
58NEK90.90701323
59FGFR20.89292479
60IKBKB0.88605233
61CAMKK20.86479691
62HIPK20.84964207
63PRKAA20.84923984
64CSF1R0.83625317
65CSK0.83496597
66CAMKK10.80359037
67CAMK1D0.80244289
68CDC42BPA0.79523933
69STK380.79494656
70STK390.78614782
71GRK70.77404025
72PAK40.76250079
73CAMK1G0.72242122
74PDK10.71765621
75DYRK1B0.71001493
76OXSR10.69581791
77PAK20.69148845
78PKN20.68519066
79RPS6KL10.68244690
80RPS6KC10.68244690
81PAK30.67785705
82EPHA30.66887209
83MAP2K20.66464760
84TESK10.65510991
85PDK30.65295552
86PDK40.65295552
87LRRK20.63043187
88TAOK20.62970454
89TAOK10.62144132
90DDR20.60105710
91FGFR30.59305982
92KSR20.59239240
93GSK3A0.58784455
94RPS6KA60.58732583
95FYN0.58020756
96FGR0.58008677
97PRKCH0.57968206
98IRAK10.57752305
99MAPK110.55737135
100TBK10.55348186
101PRKCQ0.55316521
102TYK20.55304782
103ROCK10.54108116
104ILK0.53083989
105NLK0.52134604
106OBSCN0.51969171
107RPS6KA20.51476946
108PRKD20.49409520
109TRPM70.49254005
110MAP2K10.48588869
111SIK10.48426395
112PDGFRB0.48308649
113IGF1R0.47007668
114SIK20.45753952
115JAK10.44804116
116FRK0.44213917
117CAMK40.44148875
118ADRBK10.44140586
119MAPKAPK30.43898671
120PIK3CA0.43766282
121MAP3K60.42735413
122STK100.41945338
123KIT0.41916268
124PRKCE0.39918003
125SMG10.39484030
126JAK20.38313819
127PTK20.37356775
128BCR0.37206227
129GRK50.36440020
130MET0.34750155
131EGFR0.34590370
132PIM10.34435751
133INSR0.34313372
134PDPK10.34298720
135SGK30.33538284
136MAP3K70.32765687
137DAPK30.31095779
138SRC0.30415199
139FES0.29804926
140PRKAA10.27815929
141DAPK20.27251895
142TEC0.26301658
143MAP3K110.25272902
144MAPK40.25169760
145PKN10.25147107
146PRKACB0.25014051
147RET0.24935249
148ITK0.24669746
149MARK30.23522855
150PRKACG0.20717747
151IKBKE0.20307022
152NEK60.19528019
153MAP3K10.18662396
154CAMK10.16225978

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.00071426
2Complement and coagulation cascades_Homo sapiens_hsa046102.60273736
3Fatty acid degradation_Homo sapiens_hsa000712.47061475
4Arginine biosynthesis_Homo sapiens_hsa002202.25392764
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.15685130
6Osteoclast differentiation_Homo sapiens_hsa043802.15070955
7T cell receptor signaling pathway_Homo sapiens_hsa046602.11554673
8Nitrogen metabolism_Homo sapiens_hsa009102.06396942
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.03452892
10Propanoate metabolism_Homo sapiens_hsa006402.03331581
11Tryptophan metabolism_Homo sapiens_hsa003802.01173461
12PPAR signaling pathway_Homo sapiens_hsa033201.97399845
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95684716
14ECM-receptor interaction_Homo sapiens_hsa045121.94726838
15Graft-versus-host disease_Homo sapiens_hsa053321.93674209
16Hematopoietic cell lineage_Homo sapiens_hsa046401.93330324
17Dilated cardiomyopathy_Homo sapiens_hsa054141.87349627
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87164037
19Allograft rejection_Homo sapiens_hsa053301.85847503
20Focal adhesion_Homo sapiens_hsa045101.83763052
21Bile secretion_Homo sapiens_hsa049761.81435141
22Autoimmune thyroid disease_Homo sapiens_hsa053201.81081974
23B cell receptor signaling pathway_Homo sapiens_hsa046621.79973512
24Leishmaniasis_Homo sapiens_hsa051401.71548159
25Acute myeloid leukemia_Homo sapiens_hsa052211.70923518
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.69627597
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69146203
28Fatty acid metabolism_Homo sapiens_hsa012121.61905397
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56149541
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55449846
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54285950
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53607114
33Adherens junction_Homo sapiens_hsa045201.50735712
34Measles_Homo sapiens_hsa051621.50438169
35Staphylococcus aureus infection_Homo sapiens_hsa051501.48925952
36Chemokine signaling pathway_Homo sapiens_hsa040621.44780540
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.43579052
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42882581
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40341338
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38191929
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.35678323
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.33702135
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33076107
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32168552
45Vitamin digestion and absorption_Homo sapiens_hsa049771.30556367
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28829727
47Caffeine metabolism_Homo sapiens_hsa002321.26046227
48TNF signaling pathway_Homo sapiens_hsa046681.25041683
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24906745
50ABC transporters_Homo sapiens_hsa020101.23970834
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.16222344
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16153164
53Antigen processing and presentation_Homo sapiens_hsa046121.15792295
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13727675
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13390074
56Malaria_Homo sapiens_hsa051441.10758384
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10674192
58Other glycan degradation_Homo sapiens_hsa005111.05928258
59Rap1 signaling pathway_Homo sapiens_hsa040151.04807940
60Type I diabetes mellitus_Homo sapiens_hsa049401.04349251
61Vascular smooth muscle contraction_Homo sapiens_hsa042701.04042379
62Tuberculosis_Homo sapiens_hsa051521.03148630
63Butanoate metabolism_Homo sapiens_hsa006501.02380082
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01523199
65Pertussis_Homo sapiens_hsa051331.00009259
66Pancreatic cancer_Homo sapiens_hsa052120.99859884
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99161152
68Platelet activation_Homo sapiens_hsa046110.98935565
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98143452
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95315556
71Ovarian steroidogenesis_Homo sapiens_hsa049130.94859027
72Endocytosis_Homo sapiens_hsa041440.94447113
73Chemical carcinogenesis_Homo sapiens_hsa052040.94398496
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93929211
75Insulin resistance_Homo sapiens_hsa049310.92476114
76Cardiac muscle contraction_Homo sapiens_hsa042600.90825905
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90366690
78African trypanosomiasis_Homo sapiens_hsa051430.89936051
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89769018
80Amoebiasis_Homo sapiens_hsa051460.89444488
81Renin secretion_Homo sapiens_hsa049240.88287674
82Chronic myeloid leukemia_Homo sapiens_hsa052200.86411835
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86226092
84Hepatitis B_Homo sapiens_hsa051610.86138254
85Non-small cell lung cancer_Homo sapiens_hsa052230.85729876
86Protein digestion and absorption_Homo sapiens_hsa049740.85671581
87Herpes simplex infection_Homo sapiens_hsa051680.85666921
88Peroxisome_Homo sapiens_hsa041460.83917053
89Tight junction_Homo sapiens_hsa045300.82906121
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81776953
91Influenza A_Homo sapiens_hsa051640.81626945
92beta-Alanine metabolism_Homo sapiens_hsa004100.79573414
93Arginine and proline metabolism_Homo sapiens_hsa003300.79013160
94Fatty acid elongation_Homo sapiens_hsa000620.78907910
95Choline metabolism in cancer_Homo sapiens_hsa052310.78708515
96Starch and sucrose metabolism_Homo sapiens_hsa005000.77519512
97Retinol metabolism_Homo sapiens_hsa008300.76948789
98Dorso-ventral axis formation_Homo sapiens_hsa043200.76309767
99Viral myocarditis_Homo sapiens_hsa054160.76072486
100Proteoglycans in cancer_Homo sapiens_hsa052050.75964908
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75461249
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.73556821
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72821508
104Notch signaling pathway_Homo sapiens_hsa043300.71564396
105Pyruvate metabolism_Homo sapiens_hsa006200.71255753
106Shigellosis_Homo sapiens_hsa051310.70972573
107Hepatitis C_Homo sapiens_hsa051600.70679422
108Apoptosis_Homo sapiens_hsa042100.70029533
109Phagosome_Homo sapiens_hsa041450.69896336
110HTLV-I infection_Homo sapiens_hsa051660.67826248
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67584206
112Small cell lung cancer_Homo sapiens_hsa052220.66340375
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.66010926
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.64843213
115HIF-1 signaling pathway_Homo sapiens_hsa040660.64797534
116Colorectal cancer_Homo sapiens_hsa052100.64314376
117Fat digestion and absorption_Homo sapiens_hsa049750.64183637
118Rheumatoid arthritis_Homo sapiens_hsa053230.63866030
119Histidine metabolism_Homo sapiens_hsa003400.63616267
120Renal cell carcinoma_Homo sapiens_hsa052110.62516250
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62433697
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.61406010
123MAPK signaling pathway_Homo sapiens_hsa040100.61392042
124FoxO signaling pathway_Homo sapiens_hsa040680.58420299
125Prolactin signaling pathway_Homo sapiens_hsa049170.57248677
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.57235595
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57212892
128Ras signaling pathway_Homo sapiens_hsa040140.55963915
129Arachidonic acid metabolism_Homo sapiens_hsa005900.54864736
130TGF-beta signaling pathway_Homo sapiens_hsa043500.54394289
131Inositol phosphate metabolism_Homo sapiens_hsa005620.54319717
132Axon guidance_Homo sapiens_hsa043600.54173851
133Phenylalanine metabolism_Homo sapiens_hsa003600.53462197
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53408648
135cAMP signaling pathway_Homo sapiens_hsa040240.52358397
136GnRH signaling pathway_Homo sapiens_hsa049120.51462206
137Endometrial cancer_Homo sapiens_hsa052130.51150228
138Carbon metabolism_Homo sapiens_hsa012000.50984048
139Gap junction_Homo sapiens_hsa045400.49349236
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49059868
141VEGF signaling pathway_Homo sapiens_hsa043700.48601918
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47959406
143mTOR signaling pathway_Homo sapiens_hsa041500.47908916
144Toxoplasmosis_Homo sapiens_hsa051450.47361169
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.47273182
146Salmonella infection_Homo sapiens_hsa051320.47108247
147Lysine degradation_Homo sapiens_hsa003100.46930266
148Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46811241
149Pathways in cancer_Homo sapiens_hsa052000.46601007
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46370703
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46259342
152Legionellosis_Homo sapiens_hsa051340.46200267
153Estrogen signaling pathway_Homo sapiens_hsa049150.45554951
154Tyrosine metabolism_Homo sapiens_hsa003500.42996718
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.42651835
156Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41036034
157Thyroid hormone synthesis_Homo sapiens_hsa049180.40188636
158Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39346051
159Mineral absorption_Homo sapiens_hsa049780.37920719
160Prion diseases_Homo sapiens_hsa050200.37505541
161Oxytocin signaling pathway_Homo sapiens_hsa049210.36347095
162Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36312533
163Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35879804

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