TMEM200B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.70554350
2viral transcription (GO:0019083)7.55595389
3proline metabolic process (GO:0006560)7.49596940
4chaperone-mediated protein transport (GO:0072321)7.26379521
5translational termination (GO:0006415)7.20801222
6embryonic process involved in female pregnancy (GO:0060136)7.10664988
7transcription from mitochondrial promoter (GO:0006390)6.94623105
8establishment of apical/basal cell polarity (GO:0035089)6.60565823
9regulation of integrin activation (GO:0033623)6.39961924
10positive regulation of protein homooligomerization (GO:0032464)6.34173815
11ribosomal small subunit biogenesis (GO:0042274)6.32865568
12translational elongation (GO:0006414)6.05088582
13regulation of protein homooligomerization (GO:0032462)5.95701512
14substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.78124435
15substrate-independent telencephalic tangential migration (GO:0021826)5.78124435
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.75843691
17cotranslational protein targeting to membrane (GO:0006613)5.71052834
18protein targeting to ER (GO:0045047)5.66993704
19establishment of monopolar cell polarity (GO:0061162)5.62335720
20establishment or maintenance of monopolar cell polarity (GO:0061339)5.62335720
21maturation of SSU-rRNA (GO:0030490)5.57169048
22cellular protein complex disassembly (GO:0043624)5.52222170
23replication fork processing (GO:0031297)5.49690147
24oxidative demethylation (GO:0070989)5.43146363
25establishment of protein localization to endoplasmic reticulum (GO:0072599)5.41809768
26viral life cycle (GO:0019058)5.41338224
27protein localization to endoplasmic reticulum (GO:0070972)5.31229951
28energy coupled proton transport, down electrochemical gradient (GO:0015985)5.21705547
29ATP synthesis coupled proton transport (GO:0015986)5.21705547
30behavioral response to nicotine (GO:0035095)5.09814401
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.99694406
32ribosomal small subunit assembly (GO:0000028)4.92613806
33embryonic placenta development (GO:0001892)4.91081006
34poly(A)+ mRNA export from nucleus (GO:0016973)4.90257102
35negative regulation of protein oligomerization (GO:0032460)4.76447611
36mitotic G1 DNA damage checkpoint (GO:0031571)4.69935772
37anatomical structure regression (GO:0060033)4.66787321
38protein complex disassembly (GO:0043241)4.62562339
39cellular response to ATP (GO:0071318)4.54448942
40glutamine family amino acid biosynthetic process (GO:0009084)4.48934818
41mitochondrial DNA metabolic process (GO:0032042)4.41199035
42negative regulation of fatty acid biosynthetic process (GO:0045717)4.39392148
43macromolecular complex disassembly (GO:0032984)4.31519378
44negative regulation of JAK-STAT cascade (GO:0046426)4.31220685
45translational initiation (GO:0006413)4.28494522
46negative regulation of Ras GTPase activity (GO:0034261)4.27143234
47protein neddylation (GO:0045116)4.21027250
48maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.18369380
49G1 DNA damage checkpoint (GO:0044783)4.18189835
50positive regulation of gastrulation (GO:2000543)4.10955705
51mitotic G1/S transition checkpoint (GO:0044819)4.10884186
52protein targeting to membrane (GO:0006612)4.06599464
53convergent extension (GO:0060026)4.04532530
54transmission of nerve impulse (GO:0019226)4.00962585
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.97138351
56protein localization to endosome (GO:0036010)3.93472240
57GDP-mannose metabolic process (GO:0019673)3.92176847
58regulation of protein oligomerization (GO:0032459)3.82338911
59sulfur amino acid catabolic process (GO:0000098)3.78945473
60glial cell migration (GO:0008347)3.78821761
61labyrinthine layer development (GO:0060711)3.78639288
62hypotonic response (GO:0006971)3.75158171
63mannose metabolic process (GO:0006013)3.74618341
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.74230768
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.74230768
66signal complex assembly (GO:0007172)3.69442762
67DNA strand renaturation (GO:0000733)3.69158104
68neurofilament cytoskeleton organization (GO:0060052)3.65163687
69DNA deamination (GO:0045006)3.62895462
70embryonic camera-type eye development (GO:0031076)3.59382578
71neuronal ion channel clustering (GO:0045161)3.59158185
72positive regulation of protein oligomerization (GO:0032461)3.58436271
73regulation of translational fidelity (GO:0006450)3.58385013
74face development (GO:0060324)3.57819578
75apoptotic process involved in morphogenesis (GO:0060561)3.55530763
76regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.52277993
77regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.52277993
78central nervous system myelination (GO:0022010)3.50598969
79axon ensheathment in central nervous system (GO:0032291)3.50598969
80nucleoside transmembrane transport (GO:1901642)3.46616931
81negative regulation of cell cycle arrest (GO:0071157)3.45270979
82spliceosomal tri-snRNP complex assembly (GO:0000244)3.45262275
83regulation of protein polyubiquitination (GO:1902914)3.43572022
84ribosomal large subunit biogenesis (GO:0042273)3.42868812
85cellular response to zinc ion (GO:0071294)3.40016074
86negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.39798014
87parturition (GO:0007567)3.38694249
88activation of Rac GTPase activity (GO:0032863)3.34641976
89nuclear-transcribed mRNA catabolic process (GO:0000956)3.34535544
90presynaptic membrane organization (GO:0097090)3.34495797
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34047733
92regulation of glomerular filtration (GO:0003093)3.32184295
93mRNA cleavage (GO:0006379)3.31639038
94protein heterotrimerization (GO:0070208)3.28901413
95regulation of response to reactive oxygen species (GO:1901031)3.28876836
96negative regulation of chondrocyte differentiation (GO:0032331)3.28607666
97urinary tract smooth muscle contraction (GO:0014848)3.27780414
98DNA integration (GO:0015074)3.27382502
99regulation of RNA export from nucleus (GO:0046831)3.24170162
100protein targeting to lysosome (GO:0006622)3.18603007
101establishment of protein localization to vacuole (GO:0072666)3.18603007
102protein targeting to vacuole (GO:0006623)3.18603007
103cell proliferation in forebrain (GO:0021846)3.16359879
104translation (GO:0006412)3.15272175
105regulation of podosome assembly (GO:0071801)3.14881259
106negative regulation of appetite (GO:0032099)3.14369221
107negative regulation of response to food (GO:0032096)3.14369221
108histone H4-K12 acetylation (GO:0043983)3.13822247
109sex differentiation (GO:0007548)3.13519595
110axonal fasciculation (GO:0007413)3.12516085
111regulation of cAMP-dependent protein kinase activity (GO:2000479)3.11411371
112mRNA catabolic process (GO:0006402)3.11349178
113spinal cord association neuron differentiation (GO:0021527)3.10990778
114positive regulation of developmental pigmentation (GO:0048087)3.06824825
115regulation of hydrogen peroxide-induced cell death (GO:1903205)3.05809968
116negative regulation of cartilage development (GO:0061037)3.05522799
117positive regulation of receptor recycling (GO:0001921)3.05214907
118retinoic acid receptor signaling pathway (GO:0048384)3.04598327
119regulation of cell size (GO:0008361)3.04536767
120neuron recognition (GO:0008038)3.04088796
121respiratory electron transport chain (GO:0022904)3.03402585
122gonadal mesoderm development (GO:0007506)3.03173596
123outer ear morphogenesis (GO:0042473)3.01468032
124regulation of hippo signaling (GO:0035330)2.99538480
125negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98557340
126N-glycan processing (GO:0006491)2.98451205
127trophectodermal cell differentiation (GO:0001829)2.97561762
128electron transport chain (GO:0022900)2.96267579
129nodal signaling pathway (GO:0038092)2.94614008
130pyrimidine nucleobase catabolic process (GO:0006208)2.93920969
131regulation of nucleobase-containing compound transport (GO:0032239)2.93427810
132regulation of early endosome to late endosome transport (GO:2000641)2.93212899
133ovulation cycle (GO:0042698)2.93076696
134negative regulation of focal adhesion assembly (GO:0051895)2.91523506
135negative regulation of cell junction assembly (GO:1901889)2.91523506
136negative regulation of adherens junction organization (GO:1903392)2.91523506
137positive regulation by host of viral transcription (GO:0043923)2.91287849
138dosage compensation (GO:0007549)2.91199499
139embryonic eye morphogenesis (GO:0048048)2.90563497
140anterior/posterior axis specification, embryo (GO:0008595)2.90077168
141alkaloid metabolic process (GO:0009820)2.89979171
142regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.89501934
143auditory receptor cell stereocilium organization (GO:0060088)2.87243387
144stress fiber assembly (GO:0043149)2.86785342
145synaptic transmission, dopaminergic (GO:0001963)2.86553465
146very-low-density lipoprotein particle assembly (GO:0034379)2.85081606
147establishment of protein localization to membrane (GO:0090150)2.83563545
148positive regulation of circadian rhythm (GO:0042753)2.82292715
149negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82090557
150cellular response to toxic substance (GO:0097237)2.79715420
151tachykinin receptor signaling pathway (GO:0007217)2.79270151
152dopamine transport (GO:0015872)2.78642551
153negative regulation of heart rate (GO:0010459)2.78609282
154bone morphogenesis (GO:0060349)2.78602424
155response to muscle activity (GO:0014850)2.78098207
156viral mRNA export from host cell nucleus (GO:0046784)2.77756692
157endoderm formation (GO:0001706)2.77140541
158regulation of sister chromatid cohesion (GO:0007063)2.76718394
159regulation of cholesterol homeostasis (GO:2000188)2.76403285
160negative regulation of stress fiber assembly (GO:0051497)2.75214507
161regulation of mitochondrial depolarization (GO:0051900)2.73413672
162membrane repolarization (GO:0086009)2.73118540
163protein complex biogenesis (GO:0070271)2.72562909
164establishment of protein localization to mitochondrial membrane (GO:0090151)2.72417839
165regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71642244
166regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.70967660
167ganglion development (GO:0061548)2.70018917
168cardiovascular system development (GO:0072358)2.69780331
169forebrain neuron differentiation (GO:0021879)2.69549415
170positive regulation of fatty acid beta-oxidation (GO:0032000)2.68798806
171RNA catabolic process (GO:0006401)2.68663125
172pattern specification involved in kidney development (GO:0061004)2.66787586
173retinal ganglion cell axon guidance (GO:0031290)2.66229997
174tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.64578968
175RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.64578968
176nucleoside transport (GO:0015858)2.64422954
177ATP biosynthetic process (GO:0006754)2.63958869
178exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58641134
179olfactory bulb development (GO:0021772)2.57854439
180uterus development (GO:0060065)2.57720327
181dopaminergic neuron differentiation (GO:0071542)2.56844466
182cell migration in hindbrain (GO:0021535)2.56101145
183locomotory exploration behavior (GO:0035641)2.54633999
184glucocorticoid biosynthetic process (GO:0006704)2.52977367
185cellular component biogenesis (GO:0044085)2.50816787
186nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48435622
187positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.48199579
188positive regulation of growth hormone secretion (GO:0060124)2.47882169
189neuron projection extension involved in neuron projection guidance (GO:1902284)2.47383502
190axon extension involved in axon guidance (GO:0048846)2.47383502
191adult walking behavior (GO:0007628)2.44645205
192protein targeting (GO:0006605)2.44520799
193exploration behavior (GO:0035640)2.44077962
194mitochondrial respiratory chain complex I assembly (GO:0032981)2.42673121
195NADH dehydrogenase complex assembly (GO:0010257)2.42673121
196mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.42673121
197purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.41842821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.77649482
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.84889094
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.36904050
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.34623797
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20954747
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.20475485
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.07691710
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.07691710
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.07691710
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.98692121
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.98537421
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.97922955
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.94291526
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90400239
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.78165927
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72452874
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.71029593
18LXR_22292898_ChIP-Seq_THP-1_Human2.60942922
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.59653297
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.59453566
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58830075
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58830075
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.58042406
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57519389
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.55450624
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.41942682
27* ERG_21242973_ChIP-ChIP_JURKAT_Human2.38161482
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.37952593
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.35596145
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34285191
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32347030
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21687841
33VDR_21846776_ChIP-Seq_THP-1_Human2.19318604
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18486174
35SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.18372067
36ZNF263_19887448_ChIP-Seq_K562_Human2.17715292
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13888087
38KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13328803
39POU5F1_16518401_ChIP-PET_MESCs_Mouse2.10285850
40RNF2_27304074_Chip-Seq_NSC_Mouse2.08516447
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.03175255
42REST_21632747_ChIP-Seq_MESCs_Mouse2.01006907
43ZFP281_18757296_ChIP-ChIP_E14_Mouse2.00367930
44* RACK7_27058665_Chip-Seq_MCF-7_Human1.98080629
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97535380
46CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.97107456
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.95850598
48KDM2B_26808549_Chip-Seq_DND41_Human1.92038667
49NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.91698479
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.90971341
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.85808723
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85558228
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85467797
54KDM2B_26808549_Chip-Seq_K562_Human1.83943254
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83718726
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.81854888
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.80288094
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.80050839
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77952978
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76297190
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.75863778
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75798267
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74059375
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.69597795
65TCF3_18692474_ChIP-Seq_MESCs_Mouse1.69259903
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65915496
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.62727001
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57595820
69VDR_22108803_ChIP-Seq_LS180_Human1.55533006
70NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.54807135
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.53032846
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.52759939
73* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52056574
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.51130043
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50588979
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48982194
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48473686
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47667852
79* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47351945
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45708948
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45087595
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42414636
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.40818442
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.39180289
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.38381026
86LXR_22158963_ChIP-Seq_LIVER_Mouse1.37621107
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37144124
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.36329886
89CTCF_21964334_ChIP-Seq_BJAB-B_Human1.35159122
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.34782499
91CREB1_26743006_Chip-Seq_LNCaP_Human1.32434090
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30214072
93TCF7_22412390_ChIP-Seq_EML_Mouse1.29590833
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26679521
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25236791
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25177777
97* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24754870
98PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.23818271
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22711444
100RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22547326
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20870173
102TP53_20018659_ChIP-ChIP_R1E_Mouse1.20825416
103IRF1_19129219_ChIP-ChIP_H3396_Human1.20610836
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20095520
105MYC_22102868_ChIP-Seq_BL_Human1.18980532
106RING1B_27294783_Chip-Seq_NPCs_Mouse1.18540837
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18042561
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17783840
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17310737
110NANOG_18692474_ChIP-Seq_MESCs_Mouse1.13872217
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13576323
112RARB_24833708_ChIP-Seq_LIVER_Mouse1.13182442
113TET1_21490601_ChIP-Seq_MESCs_Mouse1.13057873
114* CTCF_27219007_Chip-Seq_Bcells_Human1.12545144
115ETS1_21867929_ChIP-Seq_TH2_Mouse1.11864371
116SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11144146
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.11024873
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10417694
119* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10265881
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10213510
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08846443
122HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08655673
123* SA1_27219007_Chip-Seq_ERYTHROID_Human1.08207426
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07513887
125SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05773516
126POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05545527
127CDX2_20551321_ChIP-Seq_CACO-2_Human1.05524920
128SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05210582
129SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04839021
130BCOR_27268052_Chip-Seq_Bcells_Human1.04819852
131TP53_22127205_ChIP-Seq_IMR90_Human1.04612645
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03763225
133SPI1_26923725_Chip-Seq_HPCs_Mouse1.03692704
134KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03570689
135* RUNX1_27514584_Chip-Seq_MCF-7_Human1.02968537
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02472967
137MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02397755
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01967206
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01377004
140CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01297912
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99871501
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99633967
143DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99107367
144ATF3_27146783_Chip-Seq_COLON_Human0.98548952
145TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97541736
146FUS_26573619_Chip-Seq_HEK293_Human0.95502804
147SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95421062
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95360265
149MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95247834
150SOX2_16153702_ChIP-ChIP_HESCs_Human0.92870203
151CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92503112
152CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90006179
153SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88591932
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88031184
155ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87106879
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86571302
157P300_19829295_ChIP-Seq_ESCs_Human0.86242654
158TP53_22573176_ChIP-Seq_HFKS_Human0.85483315
159CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84659936
160RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84227989
161HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84223968
162CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84215273
163GABP_17652178_ChIP-ChIP_JURKAT_Human0.84038091
164TAF2_19829295_ChIP-Seq_ESCs_Human0.83293525
165POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83169620
166TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83169620
167EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79854061
168ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79823011
169GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77636697
170ZNF274_21170338_ChIP-Seq_K562_Hela0.77628204
171MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77547192
172GATA1_26923725_Chip-Seq_HPCs_Mouse0.77041250
173FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77012341
174ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76368710
175GBX2_23144817_ChIP-Seq_PC3_Human0.76197852
176* SA1_27219007_Chip-Seq_Bcells_Human0.75538278
177GATA3_21878914_ChIP-Seq_MCF-7_Human0.72588466
178MYC_19829295_ChIP-Seq_ESCs_Human0.72077108
179P53_22127205_ChIP-Seq_FIBROBLAST_Human0.71934908
180* FOXH1_21741376_ChIP-Seq_ESCs_Human0.71481825
181TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70997803
182* NANOG_20526341_ChIP-Seq_ESCs_Human0.70825247
183YY1_22570637_ChIP-Seq_MALME-3M_Human0.69820415
184RXR_22108803_ChIP-Seq_LS180_Human0.69230866
185* SMAD3_21741376_ChIP-Seq_ESCs_Human0.68629138
186EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68338056
187KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.68132937
188TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68112148
189EWS_26573619_Chip-Seq_HEK293_Human0.67623338
190NCOR_22424771_ChIP-Seq_293T_Human0.66815720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.13637553
2MP0009278_abnormal_bone_marrow5.23065698
3MP0008995_early_reproductive_senescence4.30609956
4MP0005171_absent_coat_pigmentation4.27735761
5MP0008057_abnormal_DNA_replication4.21892187
6MP0004233_abnormal_muscle_weight3.92926312
7MP0005423_abnormal_somatic_nervous3.55533394
8MP0010030_abnormal_orbit_morphology3.53930709
9MP0006292_abnormal_olfactory_placode3.38334668
10MP0002638_abnormal_pupillary_reflex3.19279583
11MP0002009_preneoplasia3.01264984
12MP0001529_abnormal_vocalization2.85595514
13MP0003283_abnormal_digestive_organ2.76872090
14MP0003123_paternal_imprinting2.76710319
15MP0003787_abnormal_imprinting2.68030278
16MP0002163_abnormal_gland_morphology2.65486626
17MP0003880_abnormal_central_pattern2.49868570
18MP0006276_abnormal_autonomic_nervous2.21541903
19MP0004145_abnormal_muscle_electrophysio2.18643174
20MP0003045_fibrosis2.16211741
21MP0005076_abnormal_cell_differentiation2.16163205
22MP0001545_abnormal_hematopoietic_system2.12501052
23MP0005397_hematopoietic_system_phenotyp2.12501052
24MP0001188_hyperpigmentation2.10747109
25MP0000778_abnormal_nervous_system2.08166274
26MP0002822_catalepsy2.03761832
27MP0003453_abnormal_keratinocyte_physiol2.03404592
28MP0003119_abnormal_digestive_system1.96083101
29MP0002160_abnormal_reproductive_system1.95049497
30MP0003890_abnormal_embryonic-extraembry1.94316013
31MP0003705_abnormal_hypodermis_morpholog1.93501700
32MP0002282_abnormal_trachea_morphology1.90302318
33MP0002249_abnormal_larynx_morphology1.86906072
34MP0008789_abnormal_olfactory_epithelium1.81188679
35MP0005503_abnormal_tendon_morphology1.80765282
36MP0001542_abnormal_bone_strength1.79738902
37MP0002184_abnormal_innervation1.77562833
38MP0003646_muscle_fatigue1.74907536
39MP0003786_premature_aging1.70591093
40MP0008877_abnormal_DNA_methylation1.67206610
41MP0003122_maternal_imprinting1.63149121
42MP0002653_abnormal_ependyma_morphology1.59356624
43MP0001905_abnormal_dopamine_level1.57263777
44MP0000049_abnormal_middle_ear1.56252309
45MP0000751_myopathy1.56109423
46MP0000579_abnormal_nail_morphology1.55674327
47MP0004885_abnormal_endolymph1.55439279
48MP0005394_taste/olfaction_phenotype1.54955484
49MP0005499_abnormal_olfactory_system1.54955484
50MP0002269_muscular_atrophy1.54895200
51MP0004142_abnormal_muscle_tone1.53433220
52MP0001440_abnormal_grooming_behavior1.51852431
53MP0003011_delayed_dark_adaptation1.50485357
54MP0000639_abnormal_adrenal_gland1.50400674
55MP0005085_abnormal_gallbladder_physiolo1.50267315
56MP0006072_abnormal_retinal_apoptosis1.50107537
57MP0003121_genomic_imprinting1.49400815
58MP0000462_abnormal_digestive_system1.48162058
59MP0004133_heterotaxia1.45917548
60MP0002272_abnormal_nervous_system1.45587129
61MP0005365_abnormal_bile_salt1.44976321
62MP0000955_abnormal_spinal_cord1.44866611
63MP0005058_abnormal_lysosome_morphology1.44841209
64MP0002086_abnormal_extraembryonic_tissu1.44026966
65MP0009250_abnormal_appendicular_skeleto1.43704443
66MP0003879_abnormal_hair_cell1.42008608
67MP0003315_abnormal_perineum_morphology1.39754770
68MP0005379_endocrine/exocrine_gland_phen1.39533686
69MP0010352_gastrointestinal_tract_polyps1.37290193
70MP0005623_abnormal_meninges_morphology1.34983279
71MP0002557_abnormal_social/conspecific_i1.34097275
72MP0003828_pulmonary_edema1.32776046
73MP0005377_hearing/vestibular/ear_phenot1.32279267
74MP0003878_abnormal_ear_physiology1.32279267
75MP0002752_abnormal_somatic_nervous1.31512773
76MP0004197_abnormal_fetal_growth/weight/1.30517725
77MP0001340_abnormal_eyelid_morphology1.28833346
78MP0002084_abnormal_developmental_patter1.27333118
79MP0000470_abnormal_stomach_morphology1.26173756
80MP0003172_abnormal_lysosome_physiology1.24160426
81MP0009745_abnormal_behavioral_response1.24069098
82MP0003567_abnormal_fetal_cardiomyocyte1.24034638
83MP0005330_cardiomyopathy1.22199380
84MP0005389_reproductive_system_phenotype1.20914235
85MP0003635_abnormal_synaptic_transmissio1.17273396
86MP0010630_abnormal_cardiac_muscle1.15708425
87MP0005174_abnormal_tail_pigmentation1.15237684
88MP0005551_abnormal_eye_electrophysiolog1.14621169
89MP0001986_abnormal_taste_sensitivity1.12076204
90MP0002060_abnormal_skin_morphology1.11800996
91MP0003566_abnormal_cell_adhesion1.11488200
92MP0002796_impaired_skin_barrier1.10724070
93MP0002882_abnormal_neuron_morphology1.09683277
94MP0005645_abnormal_hypothalamus_physiol1.09552090
95MP0005195_abnormal_posterior_eye1.09519374
96MP0001970_abnormal_pain_threshold1.09477543
97MP0002572_abnormal_emotion/affect_behav1.09034207
98MP0004859_abnormal_synaptic_plasticity1.07914111
99MP0001968_abnormal_touch/_nociception1.05497839
100MP0002108_abnormal_muscle_morphology1.05245674
101MP0004742_abnormal_vestibular_system1.04352336
102MP0005647_abnormal_sex_gland1.04174931
103MP0001697_abnormal_embryo_size1.03372362
104MP0003935_abnormal_craniofacial_develop1.03110445
105MP0002085_abnormal_embryonic_tissue1.02944016
106MP0002063_abnormal_learning/memory/cond1.01876314
107MP0005508_abnormal_skeleton_morphology1.01467247
108MP0000371_diluted_coat_color1.00569753
109MP0002837_dystrophic_cardiac_calcinosis0.99214464
110MP0009046_muscle_twitch0.98953071
111MP0009053_abnormal_anal_canal0.98822623
112MP0000681_abnormal_thyroid_gland0.98476519
113MP0002733_abnormal_thermal_nociception0.97912239
114MP0003137_abnormal_impulse_conducting0.97301676
115MP0001293_anophthalmia0.96835676
116MP0003385_abnormal_body_wall0.96257008
117MP0002932_abnormal_joint_morphology0.95806166
118MP0000762_abnormal_tongue_morphology0.95796792
119MP0002111_abnormal_tail_morphology0.95705917
120MP0000026_abnormal_inner_ear0.94431095
121MP0001286_abnormal_eye_development0.93817842
122MP0002734_abnormal_mechanical_nocicepti0.93083557
123MP0008438_abnormal_cutaneous_collagen0.92548579
124MP0002138_abnormal_hepatobiliary_system0.92333172
125MP0004185_abnormal_adipocyte_glucose0.91394677
126MP0002735_abnormal_chemical_nociception0.91360410
127MP0002938_white_spotting0.90960143
128MP0002928_abnormal_bile_duct0.89505884
129MP0000566_synostosis0.88548456
130MP0002168_other_aberrant_phenotype0.88258353
131MP0005023_abnormal_wound_healing0.88084728
132MP0003755_abnormal_palate_morphology0.87733650
133MP0000467_abnormal_esophagus_morphology0.87466575
134MP0004087_abnormal_muscle_fiber0.87298908
135MP0002876_abnormal_thyroid_physiology0.85539083
136MP0009115_abnormal_fat_cell0.85516209
137MP0005386_behavior/neurological_phenoty0.84815298
138MP0004924_abnormal_behavior0.84815298
139MP0004130_abnormal_muscle_cell0.84407653
140MP0004811_abnormal_neuron_physiology0.83112080
141MP0000516_abnormal_urinary_system0.83102856
142MP0005367_renal/urinary_system_phenotyp0.83102856
143MP0001485_abnormal_pinna_reflex0.82911057
144MP0008004_abnormal_stomach_pH0.82532918
145MP0001672_abnormal_embryogenesis/_devel0.81779791
146MP0005380_embryogenesis_phenotype0.81779791
147MP0002152_abnormal_brain_morphology0.80677843
148MP0000631_abnormal_neuroendocrine_gland0.77965262
149MP0005646_abnormal_pituitary_gland0.77367051
150MP0002116_abnormal_craniofacial_bone0.77176790
151MP0002736_abnormal_nociception_after0.76254237
152MP0002067_abnormal_sensory_capabilities0.75888907
153MP0002332_abnormal_exercise_endurance0.75857620
154MP0003115_abnormal_respiratory_system0.75431346
155MP0002114_abnormal_axial_skeleton0.74850404
156MP0003942_abnormal_urinary_system0.74145136
157MP0002210_abnormal_sex_determination0.73721894
158MP0003136_yellow_coat_color0.73489026
159MP0005257_abnormal_intraocular_pressure0.73026459
160MP0003938_abnormal_ear_development0.72608123
161MP0001984_abnormal_olfaction0.72415444
162MP0003861_abnormal_nervous_system0.72088515
163MP0005167_abnormal_blood-brain_barrier0.72069390
164MP0004019_abnormal_vitamin_homeostasis0.70923412
165MP0009384_cardiac_valve_regurgitation0.70820769
166MP0002925_abnormal_cardiovascular_devel0.70570465
167MP0005248_abnormal_Harderian_gland0.70376865
168MP0003091_abnormal_cell_migration0.70257994
169MP0003075_altered_response_to0.70155464
170MP0001486_abnormal_startle_reflex0.70144418
171MP0003936_abnormal_reproductive_system0.69027806
172MP0000534_abnormal_ureter_morphology0.68904582
173MP0001784_abnormal_fluid_regulation0.67735956
174MP0004084_abnormal_cardiac_muscle0.66636758
175MP0001145_abnormal_male_reproductive0.65852297
176MP0000432_abnormal_head_morphology0.64493630
177MP0003984_embryonic_growth_retardation0.64098010
178MP0004272_abnormal_basement_membrane0.63918536
179MP0002106_abnormal_muscle_physiology0.61103915
180MP0002088_abnormal_embryonic_growth/wei0.60945010
181MP0001348_abnormal_lacrimal_gland0.60384399
182MP0005266_abnormal_metabolism0.59975614
183MP0008775_abnormal_heart_ventricle0.59725566
184MP0001727_abnormal_embryo_implantation0.59667972

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)5.44970223
2Annular pancreas (HP:0001734)5.39281931
3Turricephaly (HP:0000262)5.37569890
4Ulnar bowing (HP:0003031)4.54651411
5Alopecia of scalp (HP:0002293)4.54602227
6Abnormality of cells of the erythroid lineage (HP:0012130)4.42469323
7Concave nail (HP:0001598)4.31560787
8Rib fusion (HP:0000902)4.25481005
9Coronal craniosynostosis (HP:0004440)4.15921751
10Pustule (HP:0200039)4.08206661
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.96642232
12Facial hemangioma (HP:0000329)3.94289010
13Rectovaginal fistula (HP:0000143)3.85796151
14Rectal fistula (HP:0100590)3.85796151
15Global brain atrophy (HP:0002283)3.84549613
16Myokymia (HP:0002411)3.81363230
17Increased IgM level (HP:0003496)3.81006497
18Cerebral aneurysm (HP:0004944)3.80068887
19Abnormality of the phalanges of the 2nd finger (HP:0009541)3.63202504
20Macrocytic anemia (HP:0001972)3.60397194
21Hypochromic microcytic anemia (HP:0004840)3.59114102
22Vaginal fistula (HP:0004320)3.57178391
23Polycythemia (HP:0001901)3.56424290
24Pallor (HP:0000980)3.53604549
25Intestinal fistula (HP:0100819)3.52585722
26Abnormality of male internal genitalia (HP:0000022)3.50899310
27Muscle fibrillation (HP:0010546)3.43199960
28Tongue fasciculations (HP:0001308)3.38444242
29Poikiloderma (HP:0001029)3.38423893
30Reticulocytopenia (HP:0001896)3.33136025
31Acanthocytosis (HP:0001927)3.30480928
32Diaphragmatic weakness (HP:0009113)3.30014678
33Urinary glycosaminoglycan excretion (HP:0003541)3.25809866
34Mucopolysacchariduria (HP:0008155)3.25809866
35Abnormal number of erythroid precursors (HP:0012131)3.22322535
36Short humerus (HP:0005792)3.19871590
37Abnormal rod and cone electroretinograms (HP:0008323)3.12232287
38Anteriorly placed anus (HP:0001545)3.06390292
39Abnormal pancreas size (HP:0012094)3.06106206
40Renal Fanconi syndrome (HP:0001994)3.02572059
41Diastasis recti (HP:0001540)3.00397963
42Abnormal hemoglobin (HP:0011902)3.00209554
43Increased hepatocellular lipid droplets (HP:0006565)2.99287778
44Partial duplication of the phalanx of hand (HP:0009999)2.97734165
45Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.92471476
46Vertebral hypoplasia (HP:0008417)2.92471476
47Abnormality of polysaccharide metabolism (HP:0011012)2.91780186
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.91780186
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.91780186
50Congenital hip dislocation (HP:0001374)2.91384013
51Aplasia/hypoplasia of the humerus (HP:0006507)2.88106817
52Patent foramen ovale (HP:0001655)2.86238468
53Abnormality of the aortic arch (HP:0012303)2.82002500
54Acute necrotizing encephalopathy (HP:0006965)2.81192371
55Abnormality of the 2nd finger (HP:0004100)2.80247582
56Large for gestational age (HP:0001520)2.78880054
57Agitation (HP:0000713)2.76967555
58Akinesia (HP:0002304)2.76669548
59Asymmetric septal hypertrophy (HP:0001670)2.74942096
60Premature skin wrinkling (HP:0100678)2.74491858
61Short chin (HP:0000331)2.73204652
62Bowing of the arm (HP:0006488)2.72933995
63Bowed forearm bones (HP:0003956)2.72933995
64Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.72037170
65Hyperglycinemia (HP:0002154)2.68942010
66Pancreatic islet-cell hyperplasia (HP:0004510)2.68581175
67Dysostosis multiplex (HP:0000943)2.67746424
68Clumsiness (HP:0002312)2.66540258
69Mitochondrial inheritance (HP:0001427)2.65176239
70Dyskinesia (HP:0100660)2.65022123
71Decreased muscle mass (HP:0003199)2.64696098
72Orthostatic hypotension (HP:0001278)2.61109538
73Intestinal atresia (HP:0011100)2.57495429
74Alacrima (HP:0000522)2.55800196
75Chronic otitis media (HP:0000389)2.54935919
76Focal dystonia (HP:0004373)2.52890303
77Growth hormone excess (HP:0000845)2.52451813
78Medial flaring of the eyebrow (HP:0010747)2.50739732
79Choanal stenosis (HP:0000452)2.50737106
80Joint stiffness (HP:0001387)2.50222251
81Hypotrichosis (HP:0001006)2.49169498
82Abnormality of the lower motor neuron (HP:0002366)2.48126268
83Stenosis of the external auditory canal (HP:0000402)2.47350806
84Exercise-induced myalgia (HP:0003738)2.46171263
85Septo-optic dysplasia (HP:0100842)2.44900346
86Methylmalonic acidemia (HP:0002912)2.43627360
87Abnormal mitochondria in muscle tissue (HP:0008316)2.43108035
88Hamartoma (HP:0010566)2.42980899
89Abnormality of renal resorption (HP:0011038)2.41666383
90Gait imbalance (HP:0002141)2.40436100
91Bony spicule pigmentary retinopathy (HP:0007737)2.39681394
92Narrow nasal bridge (HP:0000446)2.39469987
93Metaphyseal dysplasia (HP:0100255)2.38763325
94Metaphyseal cupping (HP:0003021)2.38361218
95Lipid accumulation in hepatocytes (HP:0006561)2.38207804
96Hypercortisolism (HP:0001578)2.38179362
97Abnormality of the phalanges of the 5th finger (HP:0004213)2.35197712
98Neurodegeneration (HP:0002180)2.31866835
99Nasal polyposis (HP:0100582)2.31598133
100Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.30668096
101Craniofacial dystonia (HP:0012179)2.29860889
102Congenital stationary night blindness (HP:0007642)2.28295071
103Bulbar palsy (HP:0001283)2.27970442
104Increased CSF lactate (HP:0002490)2.27923902
105Hepatoblastoma (HP:0002884)2.27488782
106Exertional dyspnea (HP:0002875)2.26132016
107Congenital, generalized hypertrichosis (HP:0004540)2.25864714
108Amblyopia (HP:0000646)2.25252186
109Limb dystonia (HP:0002451)2.24857861
110Generalized amyotrophy (HP:0003700)2.23107505
111Anomalous pulmonary venous return (HP:0010772)2.22607449
112Broad alveolar ridges (HP:0000187)2.22289641
113Adrenal hypoplasia (HP:0000835)2.21045369
114Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16131621
115Abnormality of alanine metabolism (HP:0010916)2.15511435
116Hyperalaninemia (HP:0003348)2.15511435
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15511435
118Acute encephalopathy (HP:0006846)2.14994781
119Congenital primary aphakia (HP:0007707)2.14672823
120Osteomalacia (HP:0002749)2.14510154
121Progressive macrocephaly (HP:0004481)2.14410131
122Type II lissencephaly (HP:0007260)2.12853231
123Hypobetalipoproteinemia (HP:0003563)2.11799907
124Pendular nystagmus (HP:0012043)2.10390436
125Chronic sinusitis (HP:0011109)2.09120985
126Abnormality of the pulmonary veins (HP:0011718)2.08726069
127Vertebral fusion (HP:0002948)2.07470326
128Selective tooth agenesis (HP:0001592)2.06731502
129Hypoplastic ischia (HP:0003175)2.06363167
130Abnormality of the phalanges of the hallux (HP:0010057)2.06044557
131Abnormality of midbrain morphology (HP:0002418)2.05419004
132Molar tooth sign on MRI (HP:0002419)2.05419004
133Infertility (HP:0000789)2.03489265
134Gonadal dysgenesis (HP:0000133)2.02338209
135Aplasia of the musculature (HP:0100854)2.01908097
136Squamous cell carcinoma (HP:0002860)2.01073320
137Albinism (HP:0001022)2.00154684
138Pancreatic fibrosis (HP:0100732)1.99666653
139Dysautonomia (HP:0002459)1.98107525
140Nephrogenic diabetes insipidus (HP:0009806)1.97752878
141Hypotelorism (HP:0000601)1.97436585
142Redundant skin (HP:0001582)1.97273941
143Basal cell carcinoma (HP:0002671)1.96778252
144Hyperphosphaturia (HP:0003109)1.96775487
145Growth hormone deficiency (HP:0000824)1.96049052
146Symphalangism affecting the phalanges of the hand (HP:0009773)1.95843901
147Split hand (HP:0001171)1.95460991
148Hypochromic anemia (HP:0001931)1.94451790
149Bifid uvula (HP:0000193)1.94440639
150Hepatocellular necrosis (HP:0001404)1.93586815
151Abnormality of the parietal bone (HP:0002696)1.92588490
152Lower limb hyperreflexia (HP:0002395)1.92088797
153Dysphonia (HP:0001618)1.90953969
154Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90467588
155Absent radius (HP:0003974)1.89806690
156Abnormality of the periventricular white matter (HP:0002518)1.89495430
157Short femoral neck (HP:0100864)1.89083233
158Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.88216496
159Myocardial infarction (HP:0001658)1.88100973
160Anosmia (HP:0000458)1.87208779
161Increased intramyocellular lipid droplets (HP:0012240)1.86531331
162Abnormal urine phosphate concentration (HP:0012599)1.85713389
163Ectopia lentis (HP:0001083)1.84424852
164Maternal diabetes (HP:0009800)1.83671917
165Increased CSF protein (HP:0002922)1.83063729
166Supranuclear gaze palsy (HP:0000605)1.82593187
167Mesangial abnormality (HP:0001966)1.82424444
168Decreased lacrimation (HP:0000633)1.82364875
169Hypoplasia of the pons (HP:0012110)1.82046912
170Hypogonadotrophic hypogonadism (HP:0000044)1.81989870
171Impulsivity (HP:0100710)1.81727771
172Hyperthyroidism (HP:0000836)1.81702509
173Poor suck (HP:0002033)1.81170187
174Abnormality of the middle phalanges of the toes (HP:0010183)1.80620039
175Abnormality of the ischium (HP:0003174)1.80596278
176Protrusio acetabuli (HP:0003179)1.80170670
177Abnormality of urine glucose concentration (HP:0011016)1.78681870
178Glycosuria (HP:0003076)1.78681870
179Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.78592293
180Coarse hair (HP:0002208)1.78474046
181Aplasia involving forearm bones (HP:0009822)1.77959461
182Absent forearm bone (HP:0003953)1.77959461
183Morphological abnormality of the pyramidal tract (HP:0002062)1.77942286
184Respiratory difficulties (HP:0002880)1.77452762
185Abnormality of the nasal mucosa (HP:0000433)1.75183552
186Thin ribs (HP:0000883)1.74810706
1873-Methylglutaconic aciduria (HP:0003535)1.74050972
188IgA deficiency (HP:0002720)1.73314047
189Vaginal atresia (HP:0000148)1.73249236
190Capillary hemangiomas (HP:0005306)1.72481578
191Upper limb amyotrophy (HP:0009129)1.68959573
192Distal upper limb amyotrophy (HP:0007149)1.68959573
193Colitis (HP:0002583)1.68767614
194Abnormality of the astrocytes (HP:0100707)1.68642325
195Astrocytoma (HP:0009592)1.68642325
196Congenital glaucoma (HP:0001087)1.68580414
197Gastrointestinal dysmotility (HP:0002579)1.68280125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.13276690
2DDR25.05173759
3MAPK154.54423928
4MAP3K64.22108837
5TYRO33.70192325
6PINK12.93401760
7MAP3K112.82762162
8CASK2.81004927
9MAP3K132.75565195
10FGR2.72076942
11PDGFRA2.70516809
12MARK12.68241872
13TLK12.63710284
14MATK2.63456227
15BMX2.44565169
16BRAF2.43330500
17DAPK12.33441692
18MINK12.25666087
19DYRK22.24636099
20ARAF2.17655417
21MAP3K42.17145608
22PRKD22.15896076
23NTRK32.11551889
24CSK2.07046174
25STK161.93952570
26UHMK11.92134599
27WNK41.88287782
28DYRK1B1.87425320
29TRIB31.85650654
30MAP2K71.79632632
31PNCK1.78629576
32RIPK11.76229307
33WNK31.74970305
34ADRBK21.68069774
35LATS21.61033195
36SGK2231.59913791
37SGK4941.59913791
38PRKCG1.54845716
39SGK21.51157150
40MAP2K41.42176831
41GRK11.41746280
42NTRK21.41509217
43YES11.38188865
44TRPM71.31748484
45ZAK1.31435504
46CDC42BPA1.31397967
47RPS6KA21.29773955
48CDK61.28941747
49PIM21.28607817
50PHKG21.28342326
51PHKG11.28342326
52ADRBK11.28178071
53AKT31.28008905
54CDK71.27329749
55ABL21.21414763
56CDK191.17833156
57LATS11.17757525
58GSK3A1.17615039
59PDK21.15554386
60RPS6KC11.11507378
61RPS6KL11.11507378
62PKN11.09824415
63DYRK1A1.06153672
64MAP3K101.06071964
65CAMK1G1.03286962
66CAMK11.02904552
67NEK21.02868397
68RPS6KA60.97768716
69MAPK110.97072155
70BMPR1B0.96400861
71GRK50.95597931
72PIM10.94756764
73TAOK30.92417245
74PASK0.92407014
75MTOR0.89867901
76LIMK10.82735177
77PRKCH0.82572875
78CDK120.81095343
79EPHB10.80787124
80GRK70.77149539
81MOS0.77052505
82CAMK1D0.75554996
83PRKACA0.74299791
84PTK20.73309101
85PAK30.72657826
86PDGFRB0.72437433
87PRKAA10.71939518
88EPHA40.71458434
89STK110.71107432
90DMPK0.70013769
91TTN0.69535627
92SGK30.65443767
93MAP2K60.63514523
94RPS6KA10.63196528
95SIK10.62900583
96CDC70.62387794
97WNK10.62126985
98CDK50.61986711
99DAPK30.61161206
100STK380.61078814
101DAPK20.59808162
102MAPK130.59684296
103AURKA0.58168513
104MAP3K90.57686946
105TAF10.57649981
106HIPK20.57252705
107PRKCD0.55881209
108PRPF4B0.54851317
109EGFR0.54710733
110PRKD30.53666476
111PAK20.51549506
112STK30.50938511
113ILK0.50283366
114PTK60.49951029
115PRKAA20.49888440
116FRK0.49660045
117NME20.49425400
118PRKCQ0.48563897
119AKT20.46695883
120CSNK1E0.45964879
121INSRR0.45573528
122CHEK20.44947929
123CAMK2G0.43803519
124TGFBR10.43602414
125PIK3CA0.43412131
126PRKCA0.42658659
127OBSCN0.42380695
128TAOK10.42162645
129PRKG10.41694557
130CDK140.40633624
131MAP2K20.40015627
132AKT10.39418013
133PAK40.38743165
134MAPK10.38288932
135PRKD10.36614364
136TAOK20.36447441
137SGK10.35986257
138FGFR10.35004325
139CAMK2B0.33867850
140ERN10.33623275
141INSR0.33047396
142MAPK30.32849940
143DYRK30.32645649
144STK38L0.31014463
145RAF10.30670345
146ERBB30.28353407
147MAPK100.27101591
148PRKCZ0.26953567
149EPHA20.26881841
150MAPK40.26158433
151CSNK1G10.23897076
152RPS6KB10.22997734
153CDK20.22867522
154ALK0.22783650
155RPS6KA30.22400410
156TNK20.22363882
157CAMK2D0.22140628
158PAK60.21349636
159TIE10.21004716
160EPHB20.20967391
161MAPK140.20593789
162CAMK2A0.20524235
163MYLK0.19189580
164PLK10.17939811
165PRKACG0.17368763
166SIK20.17306992
167PTK2B0.16679698
168JAK20.16629522
169CHUK0.16529324
170ABL10.16020356
171RPS6KB20.15272360
172MARK20.14166827

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.08954884
2Fatty acid biosynthesis_Homo sapiens_hsa000616.05542702
3Oxidative phosphorylation_Homo sapiens_hsa001904.36440083
4Parkinsons disease_Homo sapiens_hsa050123.86476045
5Cardiac muscle contraction_Homo sapiens_hsa042603.34966485
6Alzheimers disease_Homo sapiens_hsa050102.75404328
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.59277547
8Huntingtons disease_Homo sapiens_hsa050162.55132995
9Base excision repair_Homo sapiens_hsa034102.53916707
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.49288466
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40894731
12mTOR signaling pathway_Homo sapiens_hsa041502.38375835
13Fatty acid metabolism_Homo sapiens_hsa012122.27366688
14Hedgehog signaling pathway_Homo sapiens_hsa043402.20690874
15Hippo signaling pathway_Homo sapiens_hsa043902.17991448
16Notch signaling pathway_Homo sapiens_hsa043302.17551360
17Phototransduction_Homo sapiens_hsa047442.11170434
18Arginine biosynthesis_Homo sapiens_hsa002202.05157741
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04362891
20Nicotine addiction_Homo sapiens_hsa050332.03623494
21Circadian rhythm_Homo sapiens_hsa047102.02900884
22Mismatch repair_Homo sapiens_hsa034301.99919352
23Adherens junction_Homo sapiens_hsa045201.99470274
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89431385
25Arginine and proline metabolism_Homo sapiens_hsa003301.89252615
26Linoleic acid metabolism_Homo sapiens_hsa005911.84181525
27Lysine degradation_Homo sapiens_hsa003101.80712028
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76610091
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.76014632
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.73365494
31TGF-beta signaling pathway_Homo sapiens_hsa043501.70066218
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56644134
33Dorso-ventral axis formation_Homo sapiens_hsa043201.53101329
34Morphine addiction_Homo sapiens_hsa050321.51875622
35Biosynthesis of amino acids_Homo sapiens_hsa012301.51844372
36Basal cell carcinoma_Homo sapiens_hsa052171.39880266
37Bladder cancer_Homo sapiens_hsa052191.38680880
38GABAergic synapse_Homo sapiens_hsa047271.37586839
39VEGF signaling pathway_Homo sapiens_hsa043701.34595854
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33481589
41Axon guidance_Homo sapiens_hsa043601.33461493
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29075984
43Insulin secretion_Homo sapiens_hsa049111.23467729
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23025393
45Olfactory transduction_Homo sapiens_hsa047401.22566542
46Cocaine addiction_Homo sapiens_hsa050301.18479631
47Nitrogen metabolism_Homo sapiens_hsa009101.17495174
48Focal adhesion_Homo sapiens_hsa045101.15684629
49Wnt signaling pathway_Homo sapiens_hsa043101.15536851
50Dopaminergic synapse_Homo sapiens_hsa047281.14702897
51Small cell lung cancer_Homo sapiens_hsa052221.14282665
52mRNA surveillance pathway_Homo sapiens_hsa030151.10897097
53Tight junction_Homo sapiens_hsa045301.08386649
54Regulation of autophagy_Homo sapiens_hsa041401.08231065
55Glutamatergic synapse_Homo sapiens_hsa047241.07492532
56Serotonergic synapse_Homo sapiens_hsa047261.03096159
57Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01149892
58Shigellosis_Homo sapiens_hsa051311.00470009
59Long-term depression_Homo sapiens_hsa047300.99163694
60Collecting duct acid secretion_Homo sapiens_hsa049660.98896089
61Gap junction_Homo sapiens_hsa045400.95537639
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95195173
63Cholinergic synapse_Homo sapiens_hsa047250.94890520
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94446106
65Circadian entrainment_Homo sapiens_hsa047130.94435792
66AMPK signaling pathway_Homo sapiens_hsa041520.93947560
67Proteoglycans in cancer_Homo sapiens_hsa052050.93714496
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93352827
69Ether lipid metabolism_Homo sapiens_hsa005650.92493674
70RNA degradation_Homo sapiens_hsa030180.90989447
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.90294308
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90177821
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88604958
74Sulfur relay system_Homo sapiens_hsa041220.87728592
75Retinol metabolism_Homo sapiens_hsa008300.86816389
76RNA polymerase_Homo sapiens_hsa030200.86082606
77Insulin signaling pathway_Homo sapiens_hsa049100.85544836
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85246234
79Sulfur metabolism_Homo sapiens_hsa009200.84148550
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.82151052
81Arachidonic acid metabolism_Homo sapiens_hsa005900.80650910
82Chronic myeloid leukemia_Homo sapiens_hsa052200.80397862
83Bile secretion_Homo sapiens_hsa049760.80111163
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79423292
85Viral myocarditis_Homo sapiens_hsa054160.78687246
86Choline metabolism in cancer_Homo sapiens_hsa052310.78543662
87Taste transduction_Homo sapiens_hsa047420.78271325
88MicroRNAs in cancer_Homo sapiens_hsa052060.77840935
89ECM-receptor interaction_Homo sapiens_hsa045120.77775726
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74441592
91ErbB signaling pathway_Homo sapiens_hsa040120.73280831
92Fructose and mannose metabolism_Homo sapiens_hsa000510.72128150
93Amphetamine addiction_Homo sapiens_hsa050310.71732324
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.68393290
95Synaptic vesicle cycle_Homo sapiens_hsa047210.67956773
96Oocyte meiosis_Homo sapiens_hsa041140.66657223
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65727103
98p53 signaling pathway_Homo sapiens_hsa041150.65189086
99Colorectal cancer_Homo sapiens_hsa052100.64154123
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.64151964
101Estrogen signaling pathway_Homo sapiens_hsa049150.63408953
102DNA replication_Homo sapiens_hsa030300.63118815
103Protein export_Homo sapiens_hsa030600.62175734
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61606269
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.60655345
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60343349
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59622483
108Mineral absorption_Homo sapiens_hsa049780.56870463
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56082477
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55603788
111Amoebiasis_Homo sapiens_hsa051460.55531477
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55498113
113Melanoma_Homo sapiens_hsa052180.54063234
114Chemical carcinogenesis_Homo sapiens_hsa052040.53707654
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52826551
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52655466
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52131285
118PPAR signaling pathway_Homo sapiens_hsa033200.51701525
119Ras signaling pathway_Homo sapiens_hsa040140.51524690
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51071553
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50834399
122Acute myeloid leukemia_Homo sapiens_hsa052210.50273575
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50189318
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49319005
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49304887
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49163182
127Thyroid hormone synthesis_Homo sapiens_hsa049180.48189265
128Peroxisome_Homo sapiens_hsa041460.46901027
129cAMP signaling pathway_Homo sapiens_hsa040240.46514669
130MAPK signaling pathway_Homo sapiens_hsa040100.46065503
131Insulin resistance_Homo sapiens_hsa049310.45229812
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45196797
133Fatty acid degradation_Homo sapiens_hsa000710.45147028
134Endometrial cancer_Homo sapiens_hsa052130.44756464
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.43222935
136Alcoholism_Homo sapiens_hsa050340.43009362
137Rap1 signaling pathway_Homo sapiens_hsa040150.42514053
138GnRH signaling pathway_Homo sapiens_hsa049120.42436488
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41769546
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41321917
141Gastric acid secretion_Homo sapiens_hsa049710.41116476
142Complement and coagulation cascades_Homo sapiens_hsa046100.40349589
143Metabolic pathways_Homo sapiens_hsa011000.40272989
144Oxytocin signaling pathway_Homo sapiens_hsa049210.40115335
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40024916
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.39796634
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39125954
148Malaria_Homo sapiens_hsa051440.38997151
149Folate biosynthesis_Homo sapiens_hsa007900.38416310
150Fat digestion and absorption_Homo sapiens_hsa049750.37897330
151Pathways in cancer_Homo sapiens_hsa052000.37628406
152Calcium signaling pathway_Homo sapiens_hsa040200.37619093
153Glucagon signaling pathway_Homo sapiens_hsa049220.37322253
154Endocytosis_Homo sapiens_hsa041440.36996080
155Renin secretion_Homo sapiens_hsa049240.36470872
156Tyrosine metabolism_Homo sapiens_hsa003500.34649810
157Caffeine metabolism_Homo sapiens_hsa002320.33922694
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33769741
159Dilated cardiomyopathy_Homo sapiens_hsa054140.33510753
160Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32311296
161Fatty acid elongation_Homo sapiens_hsa000620.31442207
162Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31391673
163Tryptophan metabolism_Homo sapiens_hsa003800.30492367
164Selenocompound metabolism_Homo sapiens_hsa004500.29246061
165Melanogenesis_Homo sapiens_hsa049160.28102826
166Prostate cancer_Homo sapiens_hsa052150.26870344
167Glycerolipid metabolism_Homo sapiens_hsa005610.26323134
168Pancreatic cancer_Homo sapiens_hsa052120.26114909
169Protein digestion and absorption_Homo sapiens_hsa049740.25463183
170Propanoate metabolism_Homo sapiens_hsa006400.24319292
171Glioma_Homo sapiens_hsa052140.23650992
172Starch and sucrose metabolism_Homo sapiens_hsa005000.23311901
173Thyroid cancer_Homo sapiens_hsa052160.22999440

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