TMEM198

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.55738972
2synaptic vesicle maturation (GO:0016188)6.38410485
3locomotory exploration behavior (GO:0035641)5.77087951
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.73717313
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.67853179
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.44099983
7glutamate secretion (GO:0014047)5.36418520
8synaptic vesicle exocytosis (GO:0016079)5.35823755
9vocalization behavior (GO:0071625)5.27913368
10regulation of synaptic vesicle exocytosis (GO:2000300)5.22187476
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.20295767
12regulation of glutamate receptor signaling pathway (GO:1900449)5.03112171
13protein localization to synapse (GO:0035418)5.01925505
14pyrimidine nucleobase catabolic process (GO:0006208)4.83263624
15regulation of synaptic vesicle transport (GO:1902803)4.74447001
16regulation of neuronal synaptic plasticity (GO:0048168)4.70662441
17dendritic spine morphogenesis (GO:0060997)4.51796836
18exploration behavior (GO:0035640)4.51516780
19layer formation in cerebral cortex (GO:0021819)4.45833183
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.45522994
21regulation of synapse structural plasticity (GO:0051823)4.39662608
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.36837661
23neurotransmitter secretion (GO:0007269)4.35316562
24synaptic transmission, glutamatergic (GO:0035249)4.20609906
25positive regulation of synapse maturation (GO:0090129)4.01471555
26neuronal action potential propagation (GO:0019227)4.00637155
27neuron cell-cell adhesion (GO:0007158)3.99775381
28nucleobase catabolic process (GO:0046113)3.96409741
29glutamate receptor signaling pathway (GO:0007215)3.94716005
30long-term memory (GO:0007616)3.90378958
31neurotransmitter-gated ion channel clustering (GO:0072578)3.89584839
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.81433047
33positive regulation of membrane potential (GO:0045838)3.81206622
34proline transport (GO:0015824)3.79147526
35activation of protein kinase A activity (GO:0034199)3.78479936
36neuron-neuron synaptic transmission (GO:0007270)3.77120908
37establishment of mitochondrion localization (GO:0051654)3.72103924
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70918251
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.70819737
40cell-cell junction maintenance (GO:0045217)3.68817308
41dendritic spine organization (GO:0097061)3.68718546
42regulation of synaptic plasticity (GO:0048167)3.66483912
43cellular potassium ion homeostasis (GO:0030007)3.60782706
44regulation of dendritic spine morphogenesis (GO:0061001)3.58466467
45sodium ion export (GO:0071436)3.57907058
46peptidyl-glutamic acid carboxylation (GO:0017187)3.56996425
47protein carboxylation (GO:0018214)3.56996425
48synaptic vesicle endocytosis (GO:0048488)3.55590433
49regulation of neurotransmitter secretion (GO:0046928)3.53932539
50regulation of postsynaptic membrane potential (GO:0060078)3.53154116
51neuromuscular process controlling balance (GO:0050885)3.52253901
52response to pheromone (GO:0019236)3.49747151
53dendrite morphogenesis (GO:0048813)3.48422924
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48411370
55auditory behavior (GO:0031223)3.47941863
56gamma-aminobutyric acid transport (GO:0015812)3.47455889
57neuron recognition (GO:0008038)3.47099333
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.44771846
59proline metabolic process (GO:0006560)3.42554760
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.40277710
61cerebellar Purkinje cell differentiation (GO:0021702)3.38636646
62regulation of vesicle fusion (GO:0031338)3.38002016
63neurotransmitter transport (GO:0006836)3.37153438
64cell communication by electrical coupling (GO:0010644)3.33735387
65axonal fasciculation (GO:0007413)3.33712423
66response to auditory stimulus (GO:0010996)3.28279344
67protein retention in ER lumen (GO:0006621)3.27964165
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25808424
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25772891
70intestinal cholesterol absorption (GO:0030299)3.25606019
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25312074
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.23324825
73positive regulation of dendritic spine morphogenesis (GO:0061003)3.23017054
74long-term synaptic potentiation (GO:0060291)3.22174769
75regulation of neurotransmitter transport (GO:0051588)3.21585095
76positive regulation of neurotransmitter secretion (GO:0001956)3.21276080
77positive regulation of dendritic spine development (GO:0060999)3.21171523
78regulation of ARF protein signal transduction (GO:0032012)3.17539111
79glycine transport (GO:0015816)3.16631699
80regulation of cholesterol biosynthetic process (GO:0045540)3.16586115
81transmission of nerve impulse (GO:0019226)3.14894481
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.14092408
83cell migration in hindbrain (GO:0021535)3.11864393
84postsynaptic membrane organization (GO:0001941)3.11382539
85positive regulation of neurotransmitter transport (GO:0051590)3.10336166
86regulation of neurotransmitter levels (GO:0001505)3.09495853
87behavioral fear response (GO:0001662)3.07766029
88behavioral defense response (GO:0002209)3.07766029
89chemosensory behavior (GO:0007635)3.06518712
90regulation of synapse maturation (GO:0090128)3.05895457
91protein insertion into membrane (GO:0051205)3.05830464
92innervation (GO:0060384)3.05189135
93regulation of calcium ion-dependent exocytosis (GO:0017158)3.04236966
94membrane depolarization (GO:0051899)3.02247831
95central nervous system projection neuron axonogenesis (GO:0021952)3.01972880
96gamma-aminobutyric acid signaling pathway (GO:0007214)3.01791169
97learning (GO:0007612)3.00692344
98regulation of synaptic transmission (GO:0050804)3.00360434
99regulation of dendritic spine development (GO:0060998)3.00274624
100cell junction maintenance (GO:0034331)3.00264347
101membrane hyperpolarization (GO:0060081)3.00040180
102membrane depolarization during action potential (GO:0086010)2.99491241
103proline biosynthetic process (GO:0006561)2.98423445
104cerebellar Purkinje cell layer development (GO:0021680)2.97320553
105neuromuscular process controlling posture (GO:0050884)2.95408008
106prepulse inhibition (GO:0060134)2.94295469
107neuronal ion channel clustering (GO:0045161)2.93857993
108positive regulation of synaptic transmission (GO:0050806)2.92562293
109negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91610887
110fear response (GO:0042596)2.91476406
111neuromuscular process (GO:0050905)2.90850918
112synaptic transmission (GO:0007268)2.89172386
113maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88595932
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87632221
115establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85315573
116mitochondrion transport along microtubule (GO:0047497)2.85315573
117lung epithelium development (GO:0060428)2.77640653
118dicarboxylic acid transport (GO:0006835)2.76629470
119adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.73253138
120plasma lipoprotein particle assembly (GO:0034377)2.69227390
121synapse assembly (GO:0007416)2.69112897
122very-low-density lipoprotein particle assembly (GO:0034379)2.69070509
123glutamate metabolic process (GO:0006536)2.69049785
124regulation of cholesterol homeostasis (GO:2000188)2.66326406
125cholesterol biosynthetic process (GO:0006695)2.63295836
126cellular component maintenance (GO:0043954)2.62346575
127negative regulation of fibrinolysis (GO:0051918)2.60076243
128regulation of cholesterol metabolic process (GO:0090181)2.54085392
129retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52375745
130neuromuscular synaptic transmission (GO:0007274)2.51058484
131C4-dicarboxylate transport (GO:0015740)2.48147683
132presynaptic membrane assembly (GO:0097105)2.47853637
133cellular sodium ion homeostasis (GO:0006883)2.45903251
134response to dietary excess (GO:0002021)2.45098392
135regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.45016915
136cholesterol efflux (GO:0033344)2.44378242
137Golgi transport vesicle coating (GO:0048200)2.42485183
138COPI coating of Golgi vesicle (GO:0048205)2.42485183
139calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.42478699
140regulation of cholesterol esterification (GO:0010872)2.41628174
141ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.41553815
142positive regulation of dendrite morphogenesis (GO:0050775)2.40951996
143presynaptic membrane organization (GO:0097090)2.40839910
144positive regulation of mitochondrial fission (GO:0090141)2.36576783
145regulation of dendrite morphogenesis (GO:0048814)2.36335549
146protein-lipid complex assembly (GO:0065005)2.34697649
147hippocampus development (GO:0021766)2.33935181
148peristalsis (GO:0030432)2.33214828
149cerebellar granule cell differentiation (GO:0021707)2.32474724
150central nervous system myelination (GO:0022010)2.32339066
151axon ensheathment in central nervous system (GO:0032291)2.32339066
152positive regulation of synapse assembly (GO:0051965)2.31218472
153positive regulation of dendrite development (GO:1900006)2.31083127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.43451216
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.83911463
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18739097
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11567040
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03361177
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.99003528
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.96930931
8GBX2_23144817_ChIP-Seq_PC3_Human2.92331178
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.88631506
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81514947
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81514947
12DROSHA_22980978_ChIP-Seq_HELA_Human2.78649143
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.66501590
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64628105
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60553436
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59847547
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58904261
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55538841
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.54382091
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.52214672
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.52112367
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.51192281
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.33891880
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33212124
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27776792
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27537300
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.25111945
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97630838
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91400387
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82896008
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.78505355
32TET1_21451524_ChIP-Seq_MESCs_Mouse1.70363345
33SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.66034804
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61480816
35AR_21572438_ChIP-Seq_LNCaP_Human1.57375410
36P68_20966046_ChIP-Seq_HELA_Human1.56753951
37ZNF263_19887448_ChIP-Seq_K562_Human1.55675550
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53995930
39* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51143831
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51115458
41* KDM2B_26808549_Chip-Seq_K562_Human1.51059479
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.50331010
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48081142
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46751500
45SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43717944
46SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.41994466
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40500657
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40036111
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37519253
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36776152
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36288774
52ZNF274_21170338_ChIP-Seq_K562_Hela1.35766017
53* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35154456
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34440653
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.29513076
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29074734
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28605520
58* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.28076399
59SMAD4_21799915_ChIP-Seq_A2780_Human1.27654043
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26871656
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26610735
62MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.26568976
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.26205959
64* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25999186
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23175611
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21690056
67CREB1_26743006_Chip-Seq_LNCaP_Human1.20549584
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.20489113
69AR_19668381_ChIP-Seq_PC3_Human1.20460441
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20400032
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19559061
72* RARA_24833708_ChIP-Seq_LIVER_Mouse1.18422046
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17738268
74SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17564056
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17094416
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15663427
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14160706
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14079422
79TP53_22127205_ChIP-Seq_IMR90_Human1.12385073
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12116795
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12107605
82ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11843812
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11721246
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.11711730
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11143107
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10439944
87RACK7_27058665_Chip-Seq_MCF-7_Human1.09767701
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08820918
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08718562
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08459047
91* FOXP1_21924763_ChIP-Seq_HESCs_Human1.06616796
92* RARB_24833708_ChIP-Seq_LIVER_Mouse1.06370744
93CTCF_27219007_Chip-Seq_Bcells_Human1.05455654
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05437327
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.04297113
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.04004238
97* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03915046
98SOX3_22085726_ChIP-Seq_NPCs_Mouse1.03488237
99STAT3_23295773_ChIP-Seq_U87_Human1.02210795
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02070882
101AR_25329375_ChIP-Seq_VCAP_Human1.01741172
102RXR_22158963_ChIP-Seq_LIVER_Mouse1.00789928
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.00490460
104BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99745148
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98596176
106RNF2_27304074_Chip-Seq_NSC_Mouse0.98380664
107IGF1R_20145208_ChIP-Seq_DFB_Human0.98322149
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97475244
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.96895634
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95999472
111ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95287020
112PHF8_20622854_ChIP-Seq_HELA_Human0.94970309
113XRN2_22483619_ChIP-Seq_HELA_Human0.94934640
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94574199
115KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94485627
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93085828
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93073538
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.92452972
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.91377392
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90926306
121POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90911478
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90881147
123P300_19829295_ChIP-Seq_ESCs_Human0.90555201
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.90046435
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89568343
126AHR_22903824_ChIP-Seq_MCF-7_Human0.89353187
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.88698213
128LXR_22292898_ChIP-Seq_THP-1_Human0.87818157
129E2F1_20622854_ChIP-Seq_HELA_Human0.87440215
130SA1_27219007_Chip-Seq_Bcells_Human0.87253630
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.87114939
132YY1_21170310_ChIP-Seq_MESCs_Mouse0.86893546
133ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86042900
134TCF4_23295773_ChIP-Seq_U87_Human0.85092890
135ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84825840
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83442526
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80855947
138KLF4_19829295_ChIP-Seq_ESCs_Human0.80668501
139SMC4_20622854_ChIP-Seq_HELA_Human0.80326327
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80221004
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80105344
142THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79496323
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79350805
144OCT4_19829295_ChIP-Seq_ESCs_Human0.77606934
145RUNX2_22187159_ChIP-Seq_PCA_Human0.77437825
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76421430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.22021634
2MP0003635_abnormal_synaptic_transmissio4.22645121
3MP0003880_abnormal_central_pattern4.10273426
4MP0004270_analgesia3.93958905
5MP0002063_abnormal_learning/memory/cond3.47904094
6MP0009745_abnormal_behavioral_response3.34464716
7MP0002064_seizures3.02671460
8MP0002822_catalepsy2.80701352
9MP0005360_urolithiasis2.77146014
10MP0002572_abnormal_emotion/affect_behav2.76687471
11MP0005423_abnormal_somatic_nervous2.69581689
12MP0009046_muscle_twitch2.64313601
13MP0001968_abnormal_touch/_nociception2.63880813
14MP0002734_abnormal_mechanical_nocicepti2.55778013
15MP0001486_abnormal_startle_reflex2.37982749
16MP0002272_abnormal_nervous_system2.33397816
17MP0000566_synostosis2.13999409
18MP0003123_paternal_imprinting2.13018508
19MP0004858_abnormal_nervous_system2.12217863
20MP0002909_abnormal_adrenal_gland2.11740863
21MP0009780_abnormal_chondrocyte_physiolo2.08045007
22MP0002733_abnormal_thermal_nociception2.05466658
23MP0000778_abnormal_nervous_system2.03085314
24MP0008569_lethality_at_weaning2.00200672
25MP0001440_abnormal_grooming_behavior1.96563913
26MP0002735_abnormal_chemical_nociception1.95062137
27MP0002736_abnormal_nociception_after1.94561414
28MP0001501_abnormal_sleep_pattern1.93011867
29MP0001970_abnormal_pain_threshold1.92628495
30MP0004811_abnormal_neuron_physiology1.92347579
31MP0002184_abnormal_innervation1.91218857
32MP0003121_genomic_imprinting1.89336348
33MP0002557_abnormal_social/conspecific_i1.88144841
34MP0008961_abnormal_basal_metabolism1.83816453
35MP0001984_abnormal_olfaction1.82243656
36MP0003329_amyloid_beta_deposits1.79172506
37MP0002067_abnormal_sensory_capabilities1.72666382
38MP0005646_abnormal_pituitary_gland1.63962602
39MP0000955_abnormal_spinal_cord1.63895765
40MP0004924_abnormal_behavior1.63670177
41MP0005386_behavior/neurological_phenoty1.63670177
42MP0005645_abnormal_hypothalamus_physiol1.57532445
43MP0001502_abnormal_circadian_rhythm1.55107178
44MP0003122_maternal_imprinting1.54934401
45MP0003879_abnormal_hair_cell1.51969927
46MP0002882_abnormal_neuron_morphology1.49457320
47MP0004885_abnormal_endolymph1.45693866
48MP0001529_abnormal_vocalization1.44778580
49MP0006276_abnormal_autonomic_nervous1.43376630
50MP0002249_abnormal_larynx_morphology1.39173155
51MP0003787_abnormal_imprinting1.37665704
52MP0002066_abnormal_motor_capabilities/c1.37290710
53MP0003633_abnormal_nervous_system1.36162727
54MP0010329_abnormal_lipoprotein_level1.31440560
55MP0005365_abnormal_bile_salt1.27324242
56MP0000013_abnormal_adipose_tissue1.25598178
57MP0003283_abnormal_digestive_organ1.25173018
58MP0002139_abnormal_hepatobiliary_system1.19840060
59MP0002152_abnormal_brain_morphology1.18528333
60MP0004133_heterotaxia1.16059350
61MP0000049_abnormal_middle_ear1.15878120
62MP0005257_abnormal_intraocular_pressure1.11092276
63MP0003631_nervous_system_phenotype1.10673528
64MP0008789_abnormal_olfactory_epithelium1.09588568
65MP0004142_abnormal_muscle_tone1.09533644
66MP0002069_abnormal_eating/drinking_beha1.09478014
67MP0001348_abnormal_lacrimal_gland1.07628431
68MP0002638_abnormal_pupillary_reflex1.06755988
69MP0001270_distended_abdomen1.05329738
70MP0002653_abnormal_ependyma_morphology1.02967910
71MP0005394_taste/olfaction_phenotype1.01831115
72MP0005499_abnormal_olfactory_system1.01831115
73MP0003942_abnormal_urinary_system1.01317792
74MP0008875_abnormal_xenobiotic_pharmacok1.00989911
75MP0003075_altered_response_to0.98863718
76MP0001905_abnormal_dopamine_level0.96311210
77MP0010386_abnormal_urinary_bladder0.95266391
78MP0004145_abnormal_muscle_electrophysio0.94326707
79MP0000534_abnormal_ureter_morphology0.92911272
80MP0009384_cardiac_valve_regurgitation0.92577781
81MP0000678_abnormal_parathyroid_gland0.88620064
82MP0000631_abnormal_neuroendocrine_gland0.88002660
83MP0001177_atelectasis0.86924016
84MP0003119_abnormal_digestive_system0.86241860
85MP0003115_abnormal_respiratory_system0.85998014
86MP0000751_myopathy0.85864527
87MP0000569_abnormal_digit_pigmentation0.85802944
88MP0009840_abnormal_foam_cell0.82516572
89MP0003385_abnormal_body_wall0.82138464
90MP0001188_hyperpigmentation0.81072827
91MP0002229_neurodegeneration0.80836960
92MP0005535_abnormal_body_temperature0.80151442
93MP0004233_abnormal_muscle_weight0.79667132
94MP0003634_abnormal_glial_cell0.79641147
95MP0001299_abnormal_eye_distance/0.79445833
96MP0003938_abnormal_ear_development0.78738733
97MP0008260_abnormal_autophagy0.78679257
98MP0005551_abnormal_eye_electrophysiolog0.78326351
99MP0006292_abnormal_olfactory_placode0.77079056
100MP0000639_abnormal_adrenal_gland0.76831015
101MP0003172_abnormal_lysosome_physiology0.75899264
102MP0002752_abnormal_somatic_nervous0.75852425
103MP0000026_abnormal_inner_ear0.75538377
104MP0008872_abnormal_physiological_respon0.74567993
105MP0004085_abnormal_heartbeat0.74442954
106MP0003861_abnormal_nervous_system0.73213318
107MP0003890_abnormal_embryonic-extraembry0.73088617
108MP0002751_abnormal_autonomic_nervous0.72897291
109MP0005187_abnormal_penis_morphology0.72705842
110MP0002234_abnormal_pharynx_morphology0.72600099
111MP0003632_abnormal_nervous_system0.72156952
112MP0002090_abnormal_vision0.71566494
113MP0008874_decreased_physiological_sensi0.70485820
114MP0001666_abnormal_nutrient_absorption0.70139214
115MP0000604_amyloidosis0.69255363
116MP0003183_abnormal_peptide_metabolism0.66843789
117MP0001963_abnormal_hearing_physiology0.66289744
118MP0002837_dystrophic_cardiac_calcinosis0.60466500
119MP0003137_abnormal_impulse_conducting0.60066619
120MP0004043_abnormal_pH_regulation0.59594433
121MP0002089_abnormal_postnatal_growth/wei0.58850251
122MP0004742_abnormal_vestibular_system0.58497207
123MP0006072_abnormal_retinal_apoptosis0.57854806
124MP0010769_abnormal_survival0.56643935
125MP0001664_abnormal_digestion0.56130278
126MP0001943_abnormal_respiration0.53990770
127MP0003690_abnormal_glial_cell0.53890357
128MP0010770_preweaning_lethality0.53870507
129MP0002082_postnatal_lethality0.53870507
130MP0010768_mortality/aging0.53279707
131MP0003956_abnormal_body_size0.52400347

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.03319420
2Focal motor seizures (HP:0011153)6.74881229
3Focal seizures (HP:0007359)5.29770656
4Visual hallucinations (HP:0002367)5.13230426
5Epileptic encephalopathy (HP:0200134)4.50320141
6Deep venous thrombosis (HP:0002625)4.40375728
7Progressive cerebellar ataxia (HP:0002073)4.08637579
8Febrile seizures (HP:0002373)3.82807981
9Atonic seizures (HP:0010819)3.79533764
10Action tremor (HP:0002345)3.75565471
11Supranuclear gaze palsy (HP:0000605)3.74108949
12Ankle clonus (HP:0011448)3.64561624
13Absence seizures (HP:0002121)3.49003673
14Depression (HP:0000716)3.37942078
15Generalized tonic-clonic seizures (HP:0002069)3.36364120
16Dialeptic seizures (HP:0011146)3.29805939
17Impaired vibration sensation in the lower limbs (HP:0002166)3.20213522
18Papilledema (HP:0001085)3.17602915
19Poor eye contact (HP:0000817)3.17168145
20Genetic anticipation (HP:0003743)3.07163733
21Broad-based gait (HP:0002136)3.00751322
22Abnormal eating behavior (HP:0100738)2.97363812
23Amblyopia (HP:0000646)2.95891331
24Abnormality of the lower motor neuron (HP:0002366)2.94399413
25Mutism (HP:0002300)2.93843045
26Truncal ataxia (HP:0002078)2.93301447
27Anxiety (HP:0000739)2.93259813
28Prolonged partial thromboplastin time (HP:0003645)2.92778235
29Urinary bladder sphincter dysfunction (HP:0002839)2.90303539
30Hepatoblastoma (HP:0002884)2.90264115
31Dysdiadochokinesis (HP:0002075)2.88949051
32Gaze-evoked nystagmus (HP:0000640)2.87569908
33Impaired smooth pursuit (HP:0007772)2.86794268
34Impaired social interactions (HP:0000735)2.85830075
35Abnormal social behavior (HP:0012433)2.85830075
36Dysmetria (HP:0001310)2.81238009
37Torticollis (HP:0000473)2.80453506
38Hemiparesis (HP:0001269)2.76854487
39Postural instability (HP:0002172)2.74815276
40Agitation (HP:0000713)2.70675640
41Epileptiform EEG discharges (HP:0011182)2.69579166
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.66587162
43Focal dystonia (HP:0004373)2.66389087
44Broad alveolar ridges (HP:0000187)2.64096301
45Excessive salivation (HP:0003781)2.63588781
46Drooling (HP:0002307)2.63588781
47Joint hemorrhage (HP:0005261)2.62485994
48EEG with generalized epileptiform discharges (HP:0011198)2.60746907
49Aplasia/Hypoplasia of the brainstem (HP:0007362)2.59187429
50Hypoplasia of the brainstem (HP:0002365)2.59187429
51Hemorrhage of the eye (HP:0011885)2.58656602
52Ventricular fibrillation (HP:0001663)2.57509596
53Urinary urgency (HP:0000012)2.56549590
54Megalencephaly (HP:0001355)2.53440074
55Hypsarrhythmia (HP:0002521)2.52743941
56Spastic gait (HP:0002064)2.48271661
57Peripheral hypomyelination (HP:0007182)2.47455103
58Hemiplegia (HP:0002301)2.45992278
59Stereotypic behavior (HP:0000733)2.41574545
60Insomnia (HP:0100785)2.41515394
61Abnormality of ocular smooth pursuit (HP:0000617)2.41259049
62Limb dystonia (HP:0002451)2.36803360
63Cerebral hypomyelination (HP:0006808)2.36322732
64Pointed chin (HP:0000307)2.36134125
65Abnormality of binocular vision (HP:0011514)2.34942803
66Diplopia (HP:0000651)2.34942803
67Bradykinesia (HP:0002067)2.34512100
68Cortical dysplasia (HP:0002539)2.34305985
69Craniofacial dystonia (HP:0012179)2.33931807
70Hand muscle atrophy (HP:0009130)2.31845704
71Annular pancreas (HP:0001734)2.30336796
72Polyphagia (HP:0002591)2.27929686
73Neurofibrillary tangles (HP:0002185)2.27465864
74Cerebral inclusion bodies (HP:0100314)2.25287858
75Intention tremor (HP:0002080)2.25137634
76Bundle branch block (HP:0011710)2.25135458
77Hyperventilation (HP:0002883)2.22918537
78Xanthomatosis (HP:0000991)2.21999701
79Bronchomalacia (HP:0002780)2.17507088
80Akinesia (HP:0002304)2.16760288
81Neoplasm of the heart (HP:0100544)2.15223615
82Hypercholesterolemia (HP:0003124)2.14624638
83Vaginal fistula (HP:0004320)2.13203153
84Scanning speech (HP:0002168)2.12685704
85Neonatal onset (HP:0003623)2.10093053
86Hyperacusis (HP:0010780)2.09550598
87Failure to thrive in infancy (HP:0001531)2.09328327
88Pheochromocytoma (HP:0002666)2.09106185
89Lower limb muscle weakness (HP:0007340)2.08577399
90Dysmetric saccades (HP:0000641)2.08327016
91Renal duplication (HP:0000075)2.07183047
92Impaired vibratory sensation (HP:0002495)2.07144935
93Distal upper limb amyotrophy (HP:0007149)2.03641312
94Upper limb amyotrophy (HP:0009129)2.03641312
95Absent speech (HP:0001344)2.02379039
96Progressive inability to walk (HP:0002505)2.00907159
97Abnormality of the aortic arch (HP:0012303)1.98392077
98Obstructive sleep apnea (HP:0002870)1.97328352
99Abnormal EKG (HP:0003115)1.96501677
100Spastic tetraplegia (HP:0002510)1.95664923
101Fetal akinesia sequence (HP:0001989)1.94477039
102Lissencephaly (HP:0001339)1.92728068
103Amyotrophic lateral sclerosis (HP:0007354)1.92305566
104Status epilepticus (HP:0002133)1.92119714
105Alacrima (HP:0000522)1.91621480
106Clonus (HP:0002169)1.91533564
107Renovascular hypertension (HP:0100817)1.90391862
108Turricephaly (HP:0000262)1.89871655
109Ulnar bowing (HP:0003031)1.89731444
110Incomplete penetrance (HP:0003829)1.88350797
111Apathy (HP:0000741)1.88211580
112Hypoventilation (HP:0002791)1.86266510
113Impaired pain sensation (HP:0007328)1.84667361
114Abnormality of pain sensation (HP:0010832)1.84667361
115Hypercortisolism (HP:0001578)1.84589950
116Spinal canal stenosis (HP:0003416)1.84295327
117Neuroendocrine neoplasm (HP:0100634)1.83222293
118Hypoplasia of the corpus callosum (HP:0002079)1.83005633
119Choanal stenosis (HP:0000452)1.82613832
120Ankyloglossia (HP:0010296)1.80852394
121Lower limb asymmetry (HP:0100559)1.80356393
122Delusions (HP:0000746)1.79383258
123Sleep apnea (HP:0010535)1.77874346
124Thin bony cortex (HP:0002753)1.75768020
125Gait ataxia (HP:0002066)1.75132367
126Insidious onset (HP:0003587)1.74493824
127Termporal pattern (HP:0011008)1.74493824
128Cholecystitis (HP:0001082)1.73328158
129Abnormal gallbladder physiology (HP:0012438)1.73328158
130Neuronal loss in central nervous system (HP:0002529)1.73134240
131Decreased circulating renin level (HP:0003351)1.72830714
132Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72160716
133Specific learning disability (HP:0001328)1.72003674
134Muscular hypotonia of the trunk (HP:0008936)1.71228866
135Generalized myoclonic seizures (HP:0002123)1.71141243
136Deep palmar crease (HP:0006191)1.70690793
137Esotropia (HP:0000565)1.69756330
138Abnormality of salivation (HP:0100755)1.69624105
139Abnormality of the corticospinal tract (HP:0002492)1.68954120
140Poor suck (HP:0002033)1.67838551
141Retinal dysplasia (HP:0007973)1.66074014
142Abnormality of the Achilles tendon (HP:0005109)1.65548634
143Facial hemangioma (HP:0000329)1.65046825
144Abnormality of glycolysis (HP:0004366)1.64394078
145Pachygyria (HP:0001302)1.64153294
146CNS hypomyelination (HP:0003429)1.63678802
147Hammertoe (HP:0001765)1.62508312
148Hyperglycinemia (HP:0002154)1.60824806
149Exotropia (HP:0000577)1.58720304
150Abnormality of the vitreous humor (HP:0004327)1.57651251
151Broad palm (HP:0001169)1.55855823
152Heterotopia (HP:0002282)1.54886169
153Asymmetry of the thorax (HP:0001555)1.54849656
154Rib fusion (HP:0000902)1.54367212
155Generalized hypotonia (HP:0001290)1.54210436
156Truncus arteriosus (HP:0001660)1.53204702
157Athetosis (HP:0002305)1.53201330
158Elfin facies (HP:0004428)1.52712923
159Polymicrogyria (HP:0002126)1.52009120
160Delayed myelination (HP:0012448)1.51836555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.56259600
2NTRK34.32919060
3MAP3K93.89921045
4MARK13.45967578
5DAPK23.01526102
6MINK12.69102909
7MAP3K42.67098152
8PAK62.55687339
9PRKD32.53677759
10CAMKK12.46492875
11FGFR42.33368945
12KSR22.28706467
13DYRK1B2.10743625
14NTRK22.06376373
15MAP2K72.06297920
16KSR11.99403803
17DAPK11.81324760
18DYRK21.76487453
19BCR1.74179193
20NTRK11.74094673
21PKN21.68548011
22UHMK11.64654210
23CDK51.60959832
24WNK41.56426358
25TNIK1.51016398
26CSNK1G31.49338943
27TYRO31.42649240
28WNK31.41925861
29CSNK1A1L1.41766800
30MAP2K41.41721431
31STK381.38572910
32SIK21.37325824
33PRPF4B1.34556205
34MAP3K21.30820799
35MAPK131.28053257
36SIK11.26223999
37MARK21.21683739
38MAP4K21.20869220
39PRKCG1.18671936
40EEF2K1.18193137
41MAP3K131.13802730
42GRK51.13624129
43RIPK41.12526358
44TAOK11.09096918
45INSRR1.08421011
46CDK191.07903969
47PLK21.07059722
48BCKDK1.07029390
49FES1.05351111
50TESK11.02987804
51CSNK1G11.00003451
52EPHA30.98886461
53CDK180.98214159
54CAMKK20.96540394
55ARAF0.95644916
56CDK150.95144844
57ERN10.93554978
58CDK140.92756884
59PHKG10.91651517
60PHKG20.91651517
61ALK0.91106730
62PRKCH0.90626275
63CAMK10.89309074
64PAK30.88774317
65RET0.88121223
66STK110.86988235
67CDK11A0.84679130
68SCYL20.84014833
69DYRK1A0.81942632
70MAP3K120.81561245
71SGK2230.79680467
72SGK4940.79680467
73PRKAA10.79435473
74CAMK2A0.79248090
75PASK0.78619808
76CAMK1D0.78216775
77LIMK10.77363924
78CAMK2B0.77037439
79PINK10.76861859
80CSNK1G20.71939103
81LATS20.71514026
82PTK20.70840495
83FGFR20.70445647
84PIM20.69768159
85TESK20.69512943
86MAP3K110.67710450
87RAF10.66768949
88BRSK10.64156516
89SIK30.63411584
90EPHA20.63055588
91CASK0.61897783
92CAMK1G0.61617450
93ERBB20.60657188
94NEK10.59763463
95SGK10.59742302
96CDK120.59130386
97CDC42BPA0.58350799
98CSNK1E0.58043750
99RIPK10.57045971
100PRKCZ0.56989837
101PDK10.56495178
102MAP3K10.56184971
103MAP3K70.56115162
104NEK60.54374243
105AURKA0.53336754
106FGFR30.52745280
107CAMK40.51615173
108SGK30.51338986
109SGK20.50733729
110SRPK10.48473164
111PDPK10.48277783
112DAPK30.48214238
113CAMK2G0.47767178
114RPS6KA30.47680816
115ICK0.47130302
116PTK2B0.46932339
117LMTK20.46232264
118MAPK150.45459217
119MTOR0.45069916
120PNCK0.44126018
121CCNB10.43632967
122MAP2K10.43537678
123FYN0.42671211
124FGFR10.42401337
125ERBB30.41448314
126AKT20.41267517
127PRKD20.40879289
128FER0.40628953
129RPS6KA20.40433300
130MAPK100.39614804
131PRKCE0.39424388
132GSK3B0.39166987
133TRIM280.39159292
134EPHB20.38937538
135PKN10.38693786
136TRIB30.38564016
137MAPK80.38465956
138CDK80.38411166
139DDR20.36582821
140PDGFRA0.36265384
141MAP3K60.35675291
142CAMK2D0.33806002
143DMPK0.30009768

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.28395121
2Nicotine addiction_Homo sapiens_hsa050333.28053408
3Olfactory transduction_Homo sapiens_hsa047402.86589374
4Steroid biosynthesis_Homo sapiens_hsa001002.81689251
5Circadian entrainment_Homo sapiens_hsa047132.74788313
6GABAergic synapse_Homo sapiens_hsa047272.62608718
7Long-term potentiation_Homo sapiens_hsa047202.56149070
8Glutamatergic synapse_Homo sapiens_hsa047242.51334391
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48802295
10Morphine addiction_Homo sapiens_hsa050322.46273971
11Amphetamine addiction_Homo sapiens_hsa050312.43128006
12Insulin secretion_Homo sapiens_hsa049112.31845423
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.31205891
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.17960558
15Dopaminergic synapse_Homo sapiens_hsa047282.17161645
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.16205246
17Cholinergic synapse_Homo sapiens_hsa047252.02475491
18Salivary secretion_Homo sapiens_hsa049701.97571137
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93878766
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92856563
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.87898553
22Cocaine addiction_Homo sapiens_hsa050301.83271662
23Gastric acid secretion_Homo sapiens_hsa049711.77869854
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77515660
25Arginine biosynthesis_Homo sapiens_hsa002201.74986642
26Oxytocin signaling pathway_Homo sapiens_hsa049211.70813839
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70703549
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.61002043
29Taste transduction_Homo sapiens_hsa047421.56087973
30Sulfur relay system_Homo sapiens_hsa041221.54393246
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54346330
32Biosynthesis of amino acids_Homo sapiens_hsa012301.53665425
33Serotonergic synapse_Homo sapiens_hsa047261.52148286
34Renin secretion_Homo sapiens_hsa049241.48745511
35Long-term depression_Homo sapiens_hsa047301.47968395
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47758934
37GnRH signaling pathway_Homo sapiens_hsa049121.46410102
38Type II diabetes mellitus_Homo sapiens_hsa049301.44205170
39Calcium signaling pathway_Homo sapiens_hsa040201.43926660
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42557782
41Fatty acid metabolism_Homo sapiens_hsa012121.39599737
42Gap junction_Homo sapiens_hsa045401.38870300
43Fat digestion and absorption_Homo sapiens_hsa049751.38309495
44Vitamin B6 metabolism_Homo sapiens_hsa007501.33353650
45Arginine and proline metabolism_Homo sapiens_hsa003301.32253864
46cAMP signaling pathway_Homo sapiens_hsa040241.28903578
47Fatty acid biosynthesis_Homo sapiens_hsa000611.28828233
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28055429
49Estrogen signaling pathway_Homo sapiens_hsa049151.26516978
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23109841
51Axon guidance_Homo sapiens_hsa043601.22401041
52Glioma_Homo sapiens_hsa052141.20723168
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19668820
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15616246
55Collecting duct acid secretion_Homo sapiens_hsa049661.15563348
56ErbB signaling pathway_Homo sapiens_hsa040121.09902832
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08475640
58Phenylalanine metabolism_Homo sapiens_hsa003601.06751685
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05350538
60Melanogenesis_Homo sapiens_hsa049161.03426647
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03173371
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01423502
63Complement and coagulation cascades_Homo sapiens_hsa046100.98758543
64Fructose and mannose metabolism_Homo sapiens_hsa000510.95057496
65Vibrio cholerae infection_Homo sapiens_hsa051100.93435424
66Butanoate metabolism_Homo sapiens_hsa006500.93370055
67Circadian rhythm_Homo sapiens_hsa047100.93230913
68Fatty acid elongation_Homo sapiens_hsa000620.92607697
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91881742
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.89588519
71PPAR signaling pathway_Homo sapiens_hsa033200.88778550
72Oocyte meiosis_Homo sapiens_hsa041140.87893057
73AMPK signaling pathway_Homo sapiens_hsa041520.87802938
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.87703901
75Pancreatic secretion_Homo sapiens_hsa049720.86119471
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.84278706
77Dorso-ventral axis formation_Homo sapiens_hsa043200.83363094
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82890158
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79709150
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79688555
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79673795
82Thyroid hormone synthesis_Homo sapiens_hsa049180.79130172
83Nitrogen metabolism_Homo sapiens_hsa009100.78916564
84Type I diabetes mellitus_Homo sapiens_hsa049400.76691691
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76490955
86Choline metabolism in cancer_Homo sapiens_hsa052310.76189530
87mTOR signaling pathway_Homo sapiens_hsa041500.74789012
88Carbon metabolism_Homo sapiens_hsa012000.73662995
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72145760
90VEGF signaling pathway_Homo sapiens_hsa043700.71667251
91Dilated cardiomyopathy_Homo sapiens_hsa054140.71400360
92Hippo signaling pathway_Homo sapiens_hsa043900.71393835
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70859369
94MAPK signaling pathway_Homo sapiens_hsa040100.70656320
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68803170
96Phototransduction_Homo sapiens_hsa047440.68748316
97Cardiac muscle contraction_Homo sapiens_hsa042600.68405495
98Galactose metabolism_Homo sapiens_hsa000520.67953873
99Glucagon signaling pathway_Homo sapiens_hsa049220.66276726
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64632875
101Endometrial cancer_Homo sapiens_hsa052130.63795497
102Alcoholism_Homo sapiens_hsa050340.62959305
103Endocytosis_Homo sapiens_hsa041440.62275118
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62254430
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61609614
106N-Glycan biosynthesis_Homo sapiens_hsa005100.61540059
107Vitamin digestion and absorption_Homo sapiens_hsa049770.61521206
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.60490940
109ABC transporters_Homo sapiens_hsa020100.59102718
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58629027
111Pyruvate metabolism_Homo sapiens_hsa006200.57945558
112Ras signaling pathway_Homo sapiens_hsa040140.57274990
113Sphingolipid metabolism_Homo sapiens_hsa006000.56081556
114Rap1 signaling pathway_Homo sapiens_hsa040150.55438360
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55022894
116Non-small cell lung cancer_Homo sapiens_hsa052230.54993088
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52779212
118Inositol phosphate metabolism_Homo sapiens_hsa005620.52494031
119Renal cell carcinoma_Homo sapiens_hsa052110.52436764
120Prion diseases_Homo sapiens_hsa050200.51828121
121Insulin signaling pathway_Homo sapiens_hsa049100.51650820
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51143473
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.50997149
124Peroxisome_Homo sapiens_hsa041460.48099920
125Wnt signaling pathway_Homo sapiens_hsa043100.47832821
126Basal cell carcinoma_Homo sapiens_hsa052170.47142760
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46570026
128Histidine metabolism_Homo sapiens_hsa003400.46097307
129Fatty acid degradation_Homo sapiens_hsa000710.45906424
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43667219
131Colorectal cancer_Homo sapiens_hsa052100.42764850
132Bile secretion_Homo sapiens_hsa049760.42318404
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41721096
134Lysine degradation_Homo sapiens_hsa003100.41282590
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40539092
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40024452
137Chemokine signaling pathway_Homo sapiens_hsa040620.37604185
138Tyrosine metabolism_Homo sapiens_hsa003500.37552091
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36468966
140Prolactin signaling pathway_Homo sapiens_hsa049170.33334017
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.32073129
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31539504
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31365038
144Ovarian steroidogenesis_Homo sapiens_hsa049130.31234296
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.31032182
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28148096
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26934594
148Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26253532
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24692870

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