TMEM191A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.52697420
2chromosome condensation (GO:0030261)9.17679565
3DNA packaging (GO:0006323)8.90640748
4spermatid development (GO:0007286)8.77314850
5plasma membrane fusion (GO:0045026)8.62829879
6response to pheromone (GO:0019236)8.27415424
7single strand break repair (GO:0000012)8.23904683
8sperm-egg recognition (GO:0035036)8.03729460
9spermatid nucleus differentiation (GO:0007289)8.02875332
10microtubule depolymerization (GO:0007019)7.78243849
11multicellular organism reproduction (GO:0032504)7.74598324
12binding of sperm to zona pellucida (GO:0007339)7.64229048
13rRNA methylation (GO:0031167)7.39857644
14reproduction (GO:0000003)7.26163298
15phosphatidylethanolamine biosynthetic process (GO:0006646)7.06310540
16sexual reproduction (GO:0019953)6.88297406
17protein polyglutamylation (GO:0018095)6.82794471
18calcium ion-dependent exocytosis (GO:0017156)6.77242388
19negative regulation of inclusion body assembly (GO:0090084)6.72164760
20cell-cell recognition (GO:0009988)6.62100028
21protein targeting to Golgi (GO:0000042)6.54420035
22phosphatidylethanolamine metabolic process (GO:0046337)6.54197409
23rRNA modification (GO:0000154)6.46054532
24microtubule severing (GO:0051013)6.30877657
25microtubule polymerization or depolymerization (GO:0031109)6.25091259
26spermatogenesis (GO:0007283)6.21830567
27male gamete generation (GO:0048232)6.19514206
28establishment of protein localization to Golgi (GO:0072600)6.16982766
29axonemal dynein complex assembly (GO:0070286)6.08569607
30retrograde transport, vesicle recycling within Golgi (GO:0000301)6.06673179
31cellular ketone body metabolic process (GO:0046950)5.69061885
32gamete generation (GO:0007276)5.65715298
33regulation of cilium movement (GO:0003352)5.40683424
34single fertilization (GO:0007338)5.33611023
35motile cilium assembly (GO:0044458)5.31023396
36centriole replication (GO:0007099)5.16667408
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.12401600
38positive regulation of Rab GTPase activity (GO:0032851)5.08268963
39regulation of Rab GTPase activity (GO:0032313)5.08268963
40ketone body metabolic process (GO:1902224)4.98634809
41germ cell development (GO:0007281)4.93916286
42centriole assembly (GO:0098534)4.91882474
43regulation of inclusion body assembly (GO:0090083)4.90227562
44protein localization to Golgi apparatus (GO:0034067)4.71733789
45regulation of transcription involved in cell fate commitment (GO:0060850)4.69290791
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.57508534
47RNA destabilization (GO:0050779)4.55180553
48multicellular organismal reproductive process (GO:0048609)4.54777826
49polyamine biosynthetic process (GO:0006596)4.48551140
50cilium or flagellum-dependent cell motility (GO:0001539)4.42920976
51response to acidic pH (GO:0010447)4.40422961
52chromatin silencing (GO:0006342)4.34313582
53cell wall macromolecule catabolic process (GO:0016998)4.31864618
54coenzyme catabolic process (GO:0009109)4.27729134
55fertilization (GO:0009566)4.26999528
56cell wall macromolecule metabolic process (GO:0044036)4.22401122
57organic cation transport (GO:0015695)4.10166338
58nucleus organization (GO:0006997)3.99467168
59regulation of centriole replication (GO:0046599)3.88097319
60protein-DNA complex disassembly (GO:0032986)3.87202794
61nucleosome disassembly (GO:0006337)3.87202794
62regulation of T-helper 2 cell differentiation (GO:0045628)3.86056481
63epithelial cilium movement (GO:0003351)3.84000020
64regulation of microtubule-based movement (GO:0060632)3.76718554
65cellular response to pH (GO:0071467)3.69420208
66glycerol ether metabolic process (GO:0006662)3.69376010
67regulation of interleukin-13 production (GO:0032656)3.61791360
68seminiferous tubule development (GO:0072520)3.57567018
69membrane protein intracellular domain proteolysis (GO:0031293)3.50372900
70regulation of phosphoprotein phosphatase activity (GO:0043666)3.47831050
71ether metabolic process (GO:0018904)3.39789429
72cilium movement (GO:0003341)3.26494995
73musculoskeletal movement (GO:0050881)3.26383972
74multicellular organismal movement (GO:0050879)3.26383972
75cerebral cortex neuron differentiation (GO:0021895)3.22255978
76peptidyl-threonine dephosphorylation (GO:0035970)3.18507694
77histone H3-K9 demethylation (GO:0033169)3.09561718
78negative regulation of Rho protein signal transduction (GO:0035024)3.08942522
79multicellular organismal development (GO:0007275)3.03318381
80regulation of ARF GTPase activity (GO:0032312)3.03302103
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.02123517
82cell recognition (GO:0008037)3.01249439
83male meiosis (GO:0007140)3.00486550
84protein depolymerization (GO:0051261)2.97734229
85microtubule nucleation (GO:0007020)2.97182016
86homeostasis of number of cells within a tissue (GO:0048873)2.94563210
87mitochondrial fission (GO:0000266)2.93613072
88cellular biogenic amine biosynthetic process (GO:0042401)2.89675255
89negative regulation of gene expression, epigenetic (GO:0045814)2.88101482
90cofactor catabolic process (GO:0051187)2.86558245
91mitotic G1 DNA damage checkpoint (GO:0031571)2.86284182
92positive regulation of type 2 immune response (GO:0002830)2.81266999
93amine biosynthetic process (GO:0009309)2.78183781
94receptor recycling (GO:0001881)2.77456196
95cranial nerve morphogenesis (GO:0021602)2.77223728
96piRNA metabolic process (GO:0034587)2.75032227
97NAD biosynthetic process (GO:0009435)2.71709578
98acrosome reaction (GO:0007340)12.4566173
99sperm motility (GO:0030317)12.3998153
100fusion of sperm to egg plasma membrane (GO:0007342)11.4608591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.78805800
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.20902305
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.88349763
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.73213581
5ELF1_20517297_ChIP-Seq_JURKAT_Human2.70929743
6VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.47510038
7EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.31197290
8RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.27597250
9ERA_21632823_ChIP-Seq_H3396_Human2.26527337
10RAC3_21632823_ChIP-Seq_H3396_Human2.25401165
11LXR_22292898_ChIP-Seq_THP-1_Human2.23489596
12CTCF_27219007_Chip-Seq_Bcells_Human2.22235456
13* BCL6_27268052_Chip-Seq_Bcells_Human2.18615562
14P68_20966046_ChIP-Seq_HELA_Human2.15474540
15SMC4_20622854_ChIP-Seq_HELA_Human2.14667859
16BCOR_27268052_Chip-Seq_Bcells_Human2.13561848
17NANOG_20526341_ChIP-Seq_ESCs_Human2.08418277
18E2F1_20622854_ChIP-Seq_HELA_Human2.07768088
19PHF8_20622854_ChIP-Seq_HELA_Human2.03843005
20CTCF_20526341_ChIP-Seq_ESCs_Human2.02223014
21YY1_22570637_ChIP-Seq_MALME-3M_Human1.99448007
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95023157
23EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.94434422
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.91777852
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91777852
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84472600
27TP63_22573176_ChIP-Seq_HFKS_Human1.76630950
28OCT4_20526341_ChIP-Seq_ESCs_Human1.73767487
29CBP_20019798_ChIP-Seq_JUKART_Human1.73587157
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.73587157
31P300_27268052_Chip-Seq_Bcells_Human1.72865328
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70664905
33TAF2_19829295_ChIP-Seq_ESCs_Human1.68669528
34MYC_19829295_ChIP-Seq_ESCs_Human1.67451275
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.67360415
36SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.67290927
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.65642263
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63694006
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.59862872
40DROSHA_22980978_ChIP-Seq_HELA_Human1.51104225
41P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.50843649
42SA1_27219007_Chip-Seq_Bcells_Human1.50268992
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49850411
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.47770810
45ERG_20517297_ChIP-Seq_VCAP_Human1.43764742
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40703064
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.37689369
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35479993
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34308100
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34096050
51SOX2_22085726_ChIP-Seq_NPCs_Mouse1.30578109
52ER_23166858_ChIP-Seq_MCF-7_Human1.30016299
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29949893
54CTCF_21964334_Chip-Seq_Bcells_Human1.27272930
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.26146601
56EZH2_22144423_ChIP-Seq_EOC_Human1.25276100
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25106311
58RBPJ_21746931_ChIP-Seq_IB4_Human1.22498004
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21770983
60P53_21459846_ChIP-Seq_SAOS-2_Human1.21207548
61CEBPB_22108803_ChIP-Seq_LS180_Human1.21177547
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20344852
63HNFA_21074721_ChIP-Seq_CACO-2_Human1.19826178
64OCT4_19829295_ChIP-Seq_ESCs_Human1.19670573
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17938332
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.17671137
67CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.17162886
68CSB_26484114_Chip-Seq_FIBROBLAST_Human1.17099780
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16973806
70FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16726579
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.16019164
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14519011
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13866852
74FUS_26573619_Chip-Seq_HEK293_Human1.12969669
75* SPI1_20517297_ChIP-Seq_HL60_Human1.12873238
76CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11692587
77FOXP1_21924763_ChIP-Seq_HESCs_Human1.11220251
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.10064493
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09737946
80KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.09141300
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08427303
82* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07685654
83GATA3_21867929_ChIP-Seq_CD8_Mouse1.07478821
84FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04438932
85ETV1_20927104_ChIP-Seq_GIST48_Human1.03673523
86RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03263746
87SOX2_21211035_ChIP-Seq_LN229_Human1.03142247
88FOXH1_21741376_ChIP-Seq_ESCs_Human1.02392151
89GATA6_21074721_ChIP-Seq_CACO-2_Human1.01309906
90STAT1_20625510_ChIP-Seq_HELA_Human1.00828195
91RUNX_20019798_ChIP-Seq_JUKART_Human1.00073510
92E2F1_17053090_ChIP-ChIP_MCF-7_Human0.98045053
93RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97980610
94SMRT_27268052_Chip-Seq_Bcells_Human0.97927410
95AR_25329375_ChIP-Seq_VCAP_Human0.97730303
96RARA_24833708_ChIP-Seq_LIVER_Mouse0.97596102
97KLF4_19829295_ChIP-Seq_ESCs_Human0.96401229
98HOXB7_26014856_ChIP-Seq_BT474_Human0.96349301
99P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95178635
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.95070634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.84693126
2MP0003878_abnormal_ear_physiology4.84693126
3MP0003698_abnormal_male_reproductive4.43470022
4MP0005670_abnormal_white_adipose4.27678419
5MP0001929_abnormal_gametogenesis3.89716784
6MP0001348_abnormal_lacrimal_gland3.29440098
7MP0000678_abnormal_parathyroid_gland2.78032565
8MP0002161_abnormal_fertility/fecundity2.51881209
9MP0002132_abnormal_respiratory_system2.49728300
10MP0005451_abnormal_body_composition2.44370912
11MP0003718_maternal_effect2.16545165
12MP0005410_abnormal_fertilization12.4224433
13MP0002210_abnormal_sex_determination1.80380954
14MP0003011_delayed_dark_adaptation1.71847147
15MP0005379_endocrine/exocrine_gland_phen1.71057383
16MP0003646_muscle_fatigue1.70932180
17MP0002822_catalepsy1.70403512
18MP0005310_abnormal_salivary_gland1.65435246
19MP0005423_abnormal_somatic_nervous1.55800686
20MP0004510_myositis1.55326976
21MP0001145_abnormal_male_reproductive1.47282244
22MP0002249_abnormal_larynx_morphology1.43036141
23MP0003879_abnormal_hair_cell1.42889970
24MP0000653_abnormal_sex_gland1.36051278
25MP0002234_abnormal_pharynx_morphology1.31961477
26MP0001486_abnormal_startle_reflex1.29929555
27MP0001905_abnormal_dopamine_level1.26027753
28MP0004859_abnormal_synaptic_plasticity1.24412108
29MP0001968_abnormal_touch/_nociception1.21869800
30MP0001765_abnormal_ion_homeostasis1.16951651
31MP0001485_abnormal_pinna_reflex1.13881249
32MP0009053_abnormal_anal_canal1.11572008
33MP0002735_abnormal_chemical_nociception1.11495014
34MP0002138_abnormal_hepatobiliary_system1.09644443
35MP0004742_abnormal_vestibular_system1.07280809
36MP0002282_abnormal_trachea_morphology0.99679689
37MP0001963_abnormal_hearing_physiology0.93018155
38MP0002229_neurodegeneration0.91753881
39MP0005395_other_phenotype0.91583970
40MP0002127_abnormal_cardiovascular_syste0.91360326
41MP0005248_abnormal_Harderian_gland0.87689918
42MP0000681_abnormal_thyroid_gland0.83162928
43MP0000534_abnormal_ureter_morphology0.82437813
44MP0000026_abnormal_inner_ear0.79607215
45MP0008877_abnormal_DNA_methylation0.76673892
46MP0005083_abnormal_biliary_tract0.76438785
47MP0005636_abnormal_mineral_homeostasis0.74434298
48MP0002067_abnormal_sensory_capabilities0.70919963
49MP0009115_abnormal_fat_cell0.69768628
50MP0003172_abnormal_lysosome_physiology0.69300738
51MP0005666_abnormal_adipose_tissue0.67504608
52MP0000955_abnormal_spinal_cord0.67005834
53MP0009697_abnormal_copulation0.62819986
54MP0008569_lethality_at_weaning0.61772631
55MP0004233_abnormal_muscle_weight0.61733916
56MP0005367_renal/urinary_system_phenotyp0.61393014
57MP0000516_abnormal_urinary_system0.61393014
58MP0002557_abnormal_social/conspecific_i0.60971279
59MP0002733_abnormal_thermal_nociception0.60487303
60MP0008004_abnormal_stomach_pH0.59941883
61MP0005535_abnormal_body_temperature0.56540858
62MP0003077_abnormal_cell_cycle0.56055602
63MP0005551_abnormal_eye_electrophysiolog0.55763726
64MP0000470_abnormal_stomach_morphology0.55558937
65MP0004085_abnormal_heartbeat0.55094776
66MP0002572_abnormal_emotion/affect_behav0.54765531
67MP0001666_abnormal_nutrient_absorption0.53354385
68MP0005647_abnormal_sex_gland0.53072349
69MP0001873_stomach_inflammation0.52375943
70MP0005375_adipose_tissue_phenotype0.51760084
71MP0008995_early_reproductive_senescence0.51637576
72MP0005166_decreased_susceptibility_to0.51285744
73MP0001970_abnormal_pain_threshold0.50498807
74MP0009745_abnormal_behavioral_response0.50077257
75MP0002653_abnormal_ependyma_morphology0.50039470
76MP0009764_decreased_sensitivity_to0.49227318
77MP0006036_abnormal_mitochondrial_physio0.47672004
78MP0008874_decreased_physiological_sensi0.46843783
79MP0002272_abnormal_nervous_system0.45874047
80MP0001984_abnormal_olfaction0.45757133
81MP0000049_abnormal_middle_ear0.45454292
82MP0001501_abnormal_sleep_pattern0.42357755
83MP0001835_abnormal_antigen_presentation0.41565422
84MP0002254_reproductive_system_inflammat0.40869860
85MP0002693_abnormal_pancreas_physiology0.39832668
86MP0003699_abnormal_female_reproductive0.39512665
87MP0001440_abnormal_grooming_behavior0.39495187
88MP0003137_abnormal_impulse_conducting0.39148220
89MP0002734_abnormal_mechanical_nocicepti0.39117145
90MP0005167_abnormal_blood-brain_barrier0.38025803
91MP0003806_abnormal_nucleotide_metabolis0.36863876
92MP0005253_abnormal_eye_physiology0.36424500
93MP0009785_altered_susceptibility_to0.36251537
94MP0000003_abnormal_adipose_tissue0.35992841
95MP0001529_abnormal_vocalization0.35842775
96MP0005332_abnormal_amino_acid0.35665758
97MP0003936_abnormal_reproductive_system0.35184999
98MP0001764_abnormal_homeostasis0.34630055
99MP0010386_abnormal_urinary_bladder0.34543060
100MP0003631_nervous_system_phenotype0.33473216

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.54762081
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.96285989
3Absent/shortened dynein arms (HP:0200106)5.96285989
4Resting tremor (HP:0002322)5.65647622
5Asymmetric septal hypertrophy (HP:0001670)5.25758142
6Bony spicule pigmentary retinopathy (HP:0007737)5.05443303
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.87921020
8Attenuation of retinal blood vessels (HP:0007843)4.77412940
9Nasal polyposis (HP:0100582)4.56373821
10Abnormal ciliary motility (HP:0012262)4.55518149
11Infertility (HP:0000789)4.54824836
12Abnormal respiratory motile cilium physiology (HP:0012261)4.42403112
13Male infertility (HP:0003251)4.34258966
14Tubulointerstitial nephritis (HP:0001970)4.19695238
15Abnormal respiratory motile cilium morphology (HP:0005938)4.19459262
16Abnormal respiratory epithelium morphology (HP:0012253)4.19459262
17Abnormal rod and cone electroretinograms (HP:0008323)4.18818690
18Chronic hepatic failure (HP:0100626)3.99994468
19Enlarged epiphyses (HP:0010580)3.87310638
20Bell-shaped thorax (HP:0001591)3.86935917
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.80292825
22Abnormality of the nasal mucosa (HP:0000433)3.65563640
23Hyperkalemia (HP:0002153)3.65441746
24Abnormality of macular pigmentation (HP:0008002)3.62217094
25Hypoplasia of the thymus (HP:0000778)3.61407516
26Generalized aminoaciduria (HP:0002909)3.51553782
27Potter facies (HP:0002009)3.46728704
28Facial shape deformation (HP:0011334)3.46728704
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.42360737
30Postural instability (HP:0002172)3.41174594
31Abnormal spermatogenesis (HP:0008669)3.31926911
32Cone-rod dystrophy (HP:0000548)3.20847643
33Azoospermia (HP:0000027)3.18885795
34Impulsivity (HP:0100710)3.13599779
35Progressive sensorineural hearing impairment (HP:0000408)3.06487664
36Unilateral renal agenesis (HP:0000122)3.02647662
37Hypoplastic ischia (HP:0003175)3.01768103
38Abnormality of the costochondral junction (HP:0000919)2.98104284
39Abnormality of dental color (HP:0011073)2.93501695
40Amelogenesis imperfecta (HP:0000705)2.91641419
41Double outlet right ventricle (HP:0001719)2.74098025
42Congenital malformation of the right heart (HP:0011723)2.74098025
43Renal Fanconi syndrome (HP:0001994)2.72467542
44Abnormality of the aortic arch (HP:0012303)2.67483334
45Hypoalphalipoproteinemia (HP:0003233)2.65454921
46Abnormal urine output (HP:0012590)2.58105822
47Rhinitis (HP:0012384)2.52974704
48Insulin-resistant diabetes mellitus (HP:0000831)2.52527715
49Renal dysplasia (HP:0000110)2.52034937
50Abnormality of the ischium (HP:0003174)2.49583850
51Menstrual irregularities (HP:0000858)2.45098930
52Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.44578968
53Widely patent fontanelles and sutures (HP:0004492)2.43612082
54Myokymia (HP:0002411)2.41108038
55Progressive cerebellar ataxia (HP:0002073)2.38718760
56Hyperthyroidism (HP:0000836)2.32246150
57Spastic paraparesis (HP:0002313)2.30072307
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29673130
59Abnormality of renal excretion (HP:0011036)2.25190777
60Flattened epiphyses (HP:0003071)2.19507906
61Truncal obesity (HP:0001956)2.14587950
62Tetany (HP:0001281)2.14401647
63Upper limb muscle weakness (HP:0003484)2.13981682
64Stage 5 chronic kidney disease (HP:0003774)2.11958756
65Sensory axonal neuropathy (HP:0003390)2.10898800
66Hypoparathyroidism (HP:0000829)2.09797253
67Hypophosphatemic rickets (HP:0004912)2.08487613
68Abnormality of potassium homeostasis (HP:0011042)2.07735930
69Hyponatremia (HP:0002902)2.06906210
70Progressive hearing impairment (HP:0001730)2.06219860
71Hyperuricemia (HP:0002149)2.05185278
72Increased purine levels (HP:0004368)2.05185278
73Epiphyseal dysplasia (HP:0002656)2.00929236
74Recurrent pneumonia (HP:0006532)2.00308081
75Ventricular tachycardia (HP:0004756)1.99778307
76Abnormal drinking behavior (HP:0030082)1.99737972
77Polydipsia (HP:0001959)1.99737972
78Polyuria (HP:0000103)1.99271211
79Nephronophthisis (HP:0000090)1.97527712
80Renovascular hypertension (HP:0100817)1.97488783
81Abnormality of urine glucose concentration (HP:0011016)1.97213699
82Glycosuria (HP:0003076)1.97213699
83Bronchiectasis (HP:0002110)1.92166751
84Abnormality of renal resorption (HP:0011038)1.91126021
85Aplasia/Hypoplasia of the thymus (HP:0010515)1.87370937
86Portal hypertension (HP:0001409)1.86632357
87Recurrent corneal erosions (HP:0000495)1.85557350
88Peripheral hypomyelination (HP:0007182)1.85019956
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84573256
90Absent epiphyses (HP:0010577)1.84573256
91Abnormality of the parathyroid morphology (HP:0011766)1.84128051
92Chronic bronchitis (HP:0004469)1.83644391
93Bowel incontinence (HP:0002607)1.80616569
94Abnormality of the hepatic vasculature (HP:0006707)1.77333340
95Failure to thrive in infancy (HP:0001531)1.76365759
96Prolonged neonatal jaundice (HP:0006579)1.75784134
97Abnormality of the epiphysis of the femoral head (HP:0010574)1.75475580
98Abnormal large intestine physiology (HP:0012700)1.73840565
99Truncus arteriosus (HP:0001660)1.72008900
100Seborrheic dermatitis (HP:0001051)1.71072728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.76908584
2TESK17.37220873
3DDR24.55219067
4STK383.75402486
5MAP4K23.61705883
6INSRR3.13436362
7PRKD32.55480501
8PLK22.40263724
9BRD42.27898134
10MAPK152.15128189
11MST1R2.09215736
12PNCK2.07292632
13STK38L2.01102081
14PDPK11.89986620
15PINK11.82700302
16PDK11.66962221
17CAMK1G1.61038515
18ARAF1.48046066
19MAP3K91.45934308
20TESK21.41267670
21CDK71.33949859
22MAP3K111.26533812
23DYRK1B1.23960486
24KSR21.18378288
25RIPK41.18267275
26PIK3CG1.18067820
27NEK61.10928188
28BRAF1.06572993
29PRKG21.02684229
30CDK120.98840121
31PTK2B0.97963898
32WNK10.96778488
33SIK20.78095385
34LATS20.77486765
35MAP3K10.76774023
36RPS6KA20.74660150
37TLK10.73304353
38MAP3K80.70843804
39MAP3K20.70566347
40NME20.68395826
41MAP2K20.67132261
42RPS6KA10.66405867
43MARK30.65272634
44CDK30.59707871
45MUSK0.59684073
46PRKG10.58136269
47MYLK0.50742884
48DYRK30.49706479
49GRK60.49638473
50ROCK10.46065291
51UHMK10.43621674
52LATS10.42761360
53CAMK10.40957724
54MAP2K70.39460236
55CDK40.37977952
56GSK3B0.35019696
57IKBKB0.33602458
58PRKCZ0.32941781
59RPS6KC10.32735539
60RPS6KL10.32735539
61MAP3K130.32644571
62TYRO30.32373111
63CDK20.32372223
64CAMK1D0.31740353
65ZAK0.31018687
66MAPK80.30590916
67CDK10.30336825
68MAPK10.30047805
69BLK0.29535550
70MAP3K120.29248172
71DYRK20.27547777
72MAPK110.26869514
73PRKAA20.26651262
74ABL20.26420717
75BRSK10.26355770
76MTOR0.25978627
77TNK20.25676617
78MINK10.25576815
79RPS6KA60.24829959
80PAK10.24235371
81JAK30.23997299
82AURKA0.23544272
83RPS6KA50.23250634
84SGK4940.21936787
85SGK2230.21936787
86MARK20.21892558
87CSNK1G30.21772648
88PRKCG0.21429977
89CAMK40.20697005
90TRIB30.19815064
91NEK20.19188062
92MAP4K10.18320986
93CHEK10.17111504
94MAP3K30.17087167
95GRK70.15166970
96PRKCB0.14578454
97PRKCQ0.14374585
98CDK140.13502794
99CDK190.12863479
100WNK40.12691820

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.71737398
2Fatty acid biosynthesis_Homo sapiens_hsa000616.30573647
3Olfactory transduction_Homo sapiens_hsa047403.72886895
4Allograft rejection_Homo sapiens_hsa053302.40001256
5Type I diabetes mellitus_Homo sapiens_hsa049402.39005218
6Butanoate metabolism_Homo sapiens_hsa006502.36653632
7Autoimmune thyroid disease_Homo sapiens_hsa053202.29665288
8Glycerophospholipid metabolism_Homo sapiens_hsa005642.29600957
9Graft-versus-host disease_Homo sapiens_hsa053322.15881699
10Phenylalanine metabolism_Homo sapiens_hsa003602.00280343
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97634161
12Antigen processing and presentation_Homo sapiens_hsa046121.80402449
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.75622281
14Synaptic vesicle cycle_Homo sapiens_hsa047211.66848580
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64074830
16Viral myocarditis_Homo sapiens_hsa054161.56360265
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.55090932
18RNA transport_Homo sapiens_hsa030131.53050292
19Type II diabetes mellitus_Homo sapiens_hsa049301.48287809
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46602261
21Fatty acid degradation_Homo sapiens_hsa000711.44965949
22Endocytosis_Homo sapiens_hsa041441.44046536
23Taste transduction_Homo sapiens_hsa047421.40948398
24Arginine biosynthesis_Homo sapiens_hsa002201.39013564
25Sulfur relay system_Homo sapiens_hsa041221.33539207
26Fatty acid metabolism_Homo sapiens_hsa012121.23726877
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.19673095
28Arginine and proline metabolism_Homo sapiens_hsa003301.10704187
29Dorso-ventral axis formation_Homo sapiens_hsa043201.04877405
30Cardiac muscle contraction_Homo sapiens_hsa042601.02583950
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.00764064
32Tyrosine metabolism_Homo sapiens_hsa003500.95534208
33Huntingtons disease_Homo sapiens_hsa050160.89133685
34Influenza A_Homo sapiens_hsa051640.87812830
35Phototransduction_Homo sapiens_hsa047440.86399943
36Inositol phosphate metabolism_Homo sapiens_hsa005620.84639885
37PPAR signaling pathway_Homo sapiens_hsa033200.83694517
38Oocyte meiosis_Homo sapiens_hsa041140.83623083
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77558469
40Purine metabolism_Homo sapiens_hsa002300.73714926
41Selenocompound metabolism_Homo sapiens_hsa004500.72792823
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72408111
43Acute myeloid leukemia_Homo sapiens_hsa052210.69143680
44Phagosome_Homo sapiens_hsa041450.68614783
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64029043
46Salivary secretion_Homo sapiens_hsa049700.63972287
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.63372597
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62178551
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61286800
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60785078
51VEGF signaling pathway_Homo sapiens_hsa043700.59526057
52Morphine addiction_Homo sapiens_hsa050320.56126595
53Hedgehog signaling pathway_Homo sapiens_hsa043400.55027606
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51921654
55Biosynthesis of amino acids_Homo sapiens_hsa012300.51426896
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.50600692
57Circadian entrainment_Homo sapiens_hsa047130.49849294
58Calcium signaling pathway_Homo sapiens_hsa040200.48882148
59Estrogen signaling pathway_Homo sapiens_hsa049150.45413629
60Regulation of autophagy_Homo sapiens_hsa041400.45017068
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42173572
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41765549
63Metabolic pathways_Homo sapiens_hsa011000.41555785
64Herpes simplex infection_Homo sapiens_hsa051680.39072187
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38788020
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38663154
67Epstein-Barr virus infection_Homo sapiens_hsa051690.35434820
68cAMP signaling pathway_Homo sapiens_hsa040240.35410083
69Legionellosis_Homo sapiens_hsa051340.34262677
70B cell receptor signaling pathway_Homo sapiens_hsa046620.33494046
71Glycerolipid metabolism_Homo sapiens_hsa005610.33214252
72Nicotine addiction_Homo sapiens_hsa050330.33159275
73Gastric acid secretion_Homo sapiens_hsa049710.33074551
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33068699
75Renin-angiotensin system_Homo sapiens_hsa046140.30922048
76Basal transcription factors_Homo sapiens_hsa030220.30829441
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30750849
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30375459
79MAPK signaling pathway_Homo sapiens_hsa040100.29360185
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.29069962
81mRNA surveillance pathway_Homo sapiens_hsa030150.28344698
82Pyrimidine metabolism_Homo sapiens_hsa002400.28337132
83Vitamin B6 metabolism_Homo sapiens_hsa007500.27363921
84Fat digestion and absorption_Homo sapiens_hsa049750.26883344
85ABC transporters_Homo sapiens_hsa020100.26813871
86Viral carcinogenesis_Homo sapiens_hsa052030.24353375
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24044820
88Gap junction_Homo sapiens_hsa045400.23367393
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22578381
90Alcoholism_Homo sapiens_hsa050340.22078498
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.21436481
92Toxoplasmosis_Homo sapiens_hsa051450.21210098
93Base excision repair_Homo sapiens_hsa034100.20934870
94Peroxisome_Homo sapiens_hsa041460.19928844
95Carbon metabolism_Homo sapiens_hsa012000.19676484
96Oxidative phosphorylation_Homo sapiens_hsa001900.19575328
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.18803928
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.17945632
99Retinol metabolism_Homo sapiens_hsa008300.17763498
100GABAergic synapse_Homo sapiens_hsa047270.16215400

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