TMEM189-UBE2V1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)4.92890499
2cytidine deamination (GO:0009972)4.92890499
3cytidine metabolic process (GO:0046087)4.92890499
4Arp2/3 complex-mediated actin nucleation (GO:0034314)4.92826378
5Golgi transport vesicle coating (GO:0048200)4.71299209
6COPI coating of Golgi vesicle (GO:0048205)4.71299209
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.69537218
8membrane raft organization (GO:0031579)4.35336150
9protein maturation by protein folding (GO:0022417)4.32177864
10positive regulation of interleukin-8 secretion (GO:2000484)4.29346575
11pyrimidine ribonucleoside catabolic process (GO:0046133)4.22108509
12positive regulation of monocyte chemotaxis (GO:0090026)4.05793599
13actin nucleation (GO:0045010)3.98156644
14DNA deamination (GO:0045006)3.90133415
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.81385978
16regulation of defense response to virus by virus (GO:0050690)3.62367023
17T cell migration (GO:0072678)3.54498113
18lymphocyte chemotaxis (GO:0048247)3.47670563
19positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.42100746
20negative regulation of stress fiber assembly (GO:0051497)3.41046860
21negative regulation of cell size (GO:0045792)3.38895459
22NIK/NF-kappaB signaling (GO:0038061)3.33698839
23GDP-mannose metabolic process (GO:0019673)3.29085647
24protein retention in ER lumen (GO:0006621)3.25372272
25negative regulation of T cell apoptotic process (GO:0070233)3.19312889
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.17362970
27positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.14109897
28thymic T cell selection (GO:0045061)3.11804650
29pinocytosis (GO:0006907)3.09102707
30protein localization to endosome (GO:0036010)3.08189646
31negative regulation of nitric-oxide synthase activity (GO:0051001)3.07899041
32regulation of monocyte chemotaxis (GO:0090025)3.06023415
33retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.03335329
34positive regulation of lamellipodium assembly (GO:0010592)2.92747185
35mitotic nuclear envelope reassembly (GO:0007084)2.92631212
36nuclear envelope reassembly (GO:0031468)2.92631212
37positive thymic T cell selection (GO:0045059)2.90563279
38pentose-phosphate shunt (GO:0006098)2.90379081
39regulation of interleukin-8 secretion (GO:2000482)2.88146264
40eosinophil chemotaxis (GO:0048245)2.84267103
41lymphocyte migration (GO:0072676)2.82397236
42positive regulation of natural killer cell mediated immunity (GO:0002717)2.81026446
43positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.76709258
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75980324
45deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.75021782
46glucose catabolic process (GO:0006007)2.74489099
47barbed-end actin filament capping (GO:0051016)2.74329076
48chaperone mediated protein folding requiring cofactor (GO:0051085)2.73637713
49regulation of lymphocyte chemotaxis (GO:1901623)2.73069747
50regulation of T cell tolerance induction (GO:0002664)2.68783866
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68334210
52macrophage chemotaxis (GO:0048246)2.66577815
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.63946532
54peptidyl-arginine omega-N-methylation (GO:0035247)2.61590866
55regulation of chronic inflammatory response (GO:0002676)2.59991408
56hyaluronan catabolic process (GO:0030214)2.57965532
57positive regulation of macrophage differentiation (GO:0045651)2.56536768
58positive regulation of gamma-delta T cell activation (GO:0046645)2.53476775
59negative regulation of viral genome replication (GO:0045071)2.52429382
60regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.52266312
61regulation of natural killer cell mediated immunity (GO:0002715)2.52266312
62antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.51555014
63eosinophil migration (GO:0072677)2.50699495
64negative regulation of lymphocyte apoptotic process (GO:0070229)2.50649654
65negative regulation of monooxygenase activity (GO:0032769)2.50510285
66positive regulation of lamellipodium organization (GO:1902745)2.49697471
67positive regulation of T cell chemotaxis (GO:0010820)2.49614029
68regulation of T cell chemotaxis (GO:0010819)2.49614029
69platelet aggregation (GO:0070527)2.49410038
70negative regulation of viral release from host cell (GO:1902187)2.47417875
71positive regulation of lymphocyte migration (GO:2000403)2.47230904
72lipopolysaccharide-mediated signaling pathway (GO:0031663)2.46396118
73negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.46085688
74regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.45921553
75hemidesmosome assembly (GO:0031581)2.45811787
76positive regulation of tolerance induction (GO:0002645)2.42152136
77negative T cell selection (GO:0043383)2.41333020
78regulation of integrin activation (GO:0033623)2.41328971
79regulation of mitochondrial membrane potential (GO:0051881)2.38923189
80regulation of metalloenzyme activity (GO:0048552)2.36084731
81membrane protein ectodomain proteolysis (GO:0006509)2.34821532
82positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.34327493
83positive regulation of cell adhesion mediated by integrin (GO:0033630)2.33608978
84regulation of lymphocyte migration (GO:2000401)2.32655207
85pyrimidine nucleoside catabolic process (GO:0046135)2.32629472
86NADPH regeneration (GO:0006740)2.32433264
87pentose metabolic process (GO:0019321)2.31838956
88regulation of mononuclear cell migration (GO:0071675)2.29833172
89regulation of apoptotic process involved in morphogenesis (GO:1902337)2.29719638
90endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.29257034
91cellular zinc ion homeostasis (GO:0006882)2.29135180
92iron-sulfur cluster assembly (GO:0016226)2.29118538
93metallo-sulfur cluster assembly (GO:0031163)2.29118538
94regulation of translational termination (GO:0006449)2.27224299
95positive regulation of interleukin-4 production (GO:0032753)2.26614647
96positive regulation of keratinocyte differentiation (GO:0045618)2.25599283
97sequestering of actin monomers (GO:0042989)2.25124478
98T cell selection (GO:0045058)2.23531098
99regulation of T cell apoptotic process (GO:0070232)2.22528813
100positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.22331740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.21344297
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.32129620
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.16876460
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54314204
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53385342
6* ELK3_25401928_ChIP-Seq_HUVEC_Human2.49795219
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48585921
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.45992154
9LXR_22292898_ChIP-Seq_THP-1_Human2.33717771
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.29806237
11ZNF263_19887448_ChIP-Seq_K562_Human2.14585234
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12453910
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02795328
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90313144
15VDR_21846776_ChIP-Seq_THP-1_Human1.83992463
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79067061
17RACK7_27058665_Chip-Seq_MCF-7_Human1.78134963
18STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75603359
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.74979030
20MYC_22102868_ChIP-Seq_BL_Human1.68513595
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64077943
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58497408
23MAF_26560356_Chip-Seq_TH1_Human1.54131195
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52447844
25UTX_26944678_Chip-Seq_JUKART_Human1.50355757
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49927261
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49744367
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49156856
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.48485176
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47788646
31HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.47711367
32ELF1_20517297_ChIP-Seq_JURKAT_Human1.47538172
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47296544
34P68_20966046_ChIP-Seq_HELA_Human1.47107662
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46188794
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45936863
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45905110
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44984525
39BCL6_27268052_Chip-Seq_Bcells_Human1.43479396
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41546830
41MAF_26560356_Chip-Seq_TH2_Human1.40884970
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40121666
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40055250
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36183360
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34610251
46VDR_24763502_ChIP-Seq_THP-1_Human1.33650170
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33469768
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31500307
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31480010
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31320032
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29725212
52BCOR_27268052_Chip-Seq_Bcells_Human1.29356927
53ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28106366
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.27894321
55ATF3_27146783_Chip-Seq_COLON_Human1.26216222
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26120069
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24426533
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.22531542
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22303047
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.22067178
61KDM2B_26808549_Chip-Seq_DND41_Human1.20783459
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19851912
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18504832
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18348144
65TCF7_22412390_ChIP-Seq_EML_Mouse1.18221809
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.16023664
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15249173
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14981364
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.14792711
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14188808
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14094392
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13842671
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13820687
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13196867
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11307958
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09346708
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08826072
78SMC4_20622854_ChIP-Seq_HELA_Human1.07265932
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06559420
80CTCF_26484167_Chip-Seq_Bcells_Mouse1.05287299
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05247189
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05133257
83MYB_26560356_Chip-Seq_TH2_Human1.02140653
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01215163
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99746186
86MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99312819
87TRIM28_21343339_ChIP-Seq_HEK293_Human0.99056347
88TP53_22127205_ChIP-Seq_IMR90_Human0.98886923
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98744294
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98352845
91RARB_24833708_ChIP-Seq_LIVER_Mouse0.98134136
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97642195
93GATA1_19941827_ChIP-Seq_MEL_Mouse0.97141299
94CTCF_20526341_ChIP-Seq_ESCs_Human0.97054151
95SPI1_23127762_ChIP-Seq_K562_Human0.96501715
96CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96431409
97SPI1_23547873_ChIP-Seq_NB4_Human0.96091097
98CTCF_21964334_Chip-Seq_Bcells_Human0.96065136
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.95865808
100NCOR1_26117541_ChIP-Seq_K562_Human0.94952744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.12235560
2MP0005058_abnormal_lysosome_morphology2.89328044
3MP0008438_abnormal_cutaneous_collagen2.87592189
4MP0005671_abnormal_response_to2.82212325
5MP0005257_abnormal_intraocular_pressure2.72501973
6MP0009333_abnormal_splenocyte_physiolog2.56732910
7MP0003705_abnormal_hypodermis_morpholog2.48372315
8MP0005464_abnormal_platelet_physiology2.44339776
9MP0009785_altered_susceptibility_to2.43991495
10MP0003566_abnormal_cell_adhesion2.41328582
11MP0005451_abnormal_body_composition2.35149001
12MP0003191_abnormal_cellular_cholesterol2.27288189
13MP0003436_decreased_susceptibility_to2.13852289
14MP0002148_abnormal_hypersensitivity_rea2.03273674
15MP0004947_skin_inflammation2.00075026
16MP0000858_altered_metastatic_potential1.96171784
17MP0008260_abnormal_autophagy1.91031602
18MP0003448_altered_tumor_morphology1.85420709
19MP0006082_CNS_inflammation1.84277020
20MP0004272_abnormal_basement_membrane1.80202517
21MP0003763_abnormal_thymus_physiology1.79556339
22MP0005025_abnormal_response_to1.78217581
23MP0001542_abnormal_bone_strength1.77392699
24MP0005000_abnormal_immune_tolerance1.75623715
25MP0009840_abnormal_foam_cell1.75233156
26MP0001835_abnormal_antigen_presentation1.73832829
27MP0004233_abnormal_muscle_weight1.70308411
28MP0000343_altered_response_to1.69416995
29MP0003279_aneurysm1.68970105
30MP0003075_altered_response_to1.64306097
31MP0003950_abnormal_plasma_membrane1.64017342
32MP0005623_abnormal_meninges_morphology1.58508420
33MP0003453_abnormal_keratinocyte_physiol1.57047123
34MP0002796_impaired_skin_barrier1.53182770
35MP0005023_abnormal_wound_healing1.49951409
36MP0004510_myositis1.48500402
37MP0001849_ear_inflammation1.47889571
38MP0001853_heart_inflammation1.42798066
39MP0005501_abnormal_skin_physiology1.38904933
40MP0003091_abnormal_cell_migration1.37057435
41MP0001873_stomach_inflammation1.37010000
42MP0002723_abnormal_immune_serum1.33112552
43MP0002060_abnormal_skin_morphology1.32983792
44MP0003866_abnormal_defecation1.32050166
45MP0002420_abnormal_adaptive_immunity1.31901274
46MP0002419_abnormal_innate_immunity1.31334227
47MP0010155_abnormal_intestine_physiology1.30699310
48MP0000678_abnormal_parathyroid_gland1.30335847
49MP0001819_abnormal_immune_cell1.29369000
50MP0010368_abnormal_lymphatic_system1.28017369
51MP0001533_abnormal_skeleton_physiology1.26639898
52MP0001958_emphysema1.23456417
53MP0000751_myopathy1.22101154
54MP0002452_abnormal_antigen_presenting1.20724029
55MP0000685_abnormal_immune_system1.20523735
56MP0005166_decreased_susceptibility_to1.19054628
57MP0003172_abnormal_lysosome_physiology1.18945109
58MP0002998_abnormal_bone_remodeling1.17126456
59MP0003300_gastrointestinal_ulcer1.16893175
60MP0003303_peritoneal_inflammation1.15688878
61MP0001243_abnormal_dermal_layer1.14968319
62MP0001845_abnormal_inflammatory_respons1.13374378
63MP0002405_respiratory_system_inflammati1.12606852
64MP0001216_abnormal_epidermal_layer1.12122800
65MP0000465_gastrointestinal_hemorrhage1.10884506
66MP0000749_muscle_degeneration1.09786182
67MP0005165_increased_susceptibility_to1.09350395
68MP0001790_abnormal_immune_system1.07843176
69MP0005387_immune_system_phenotype1.07843176
70MP0002398_abnormal_bone_marrow1.07475053
71MP0002722_abnormal_immune_system1.06617076
72MP0000716_abnormal_immune_system1.02928745
73MP0008469_abnormal_protein_level1.01643239
74MP0000467_abnormal_esophagus_morphology1.01169703
75MP0003045_fibrosis1.01059222
76MP0004858_abnormal_nervous_system0.99354515
77MP0002429_abnormal_blood_cell0.97600453
78MP0005410_abnormal_fertilization0.97259562
79MP0001800_abnormal_humoral_immune0.97221010
80MP0002166_altered_tumor_susceptibility0.96603759
81MP0005330_cardiomyopathy0.95936046
82MP0005390_skeleton_phenotype0.95739791
83MP0010234_abnormal_vibrissa_follicle0.95449508
84MP0000750_abnormal_muscle_regeneration0.93070412
85MP0009764_decreased_sensitivity_to0.91557324
86MP0000604_amyloidosis0.91517299
87MP0000767_abnormal_smooth_muscle0.91451514
88MP0000703_abnormal_thymus_morphology0.91207716
89MP0002006_tumorigenesis0.89067156
90MP0003329_amyloid_beta_deposits0.88465102
91MP0003806_abnormal_nucleotide_metabolis0.87177151
92MP0001348_abnormal_lacrimal_gland0.84704410
93MP0005083_abnormal_biliary_tract0.83982743
94MP0009763_increased_sensitivity_to0.83669120
95MP0005275_abnormal_skin_tensile0.83438618
96MP0003795_abnormal_bone_structure0.83109604
97MP0006054_spinal_hemorrhage0.81652307
98MP0000689_abnormal_spleen_morphology0.81237531
99MP0002933_joint_inflammation0.81227303
100MP0000490_abnormal_crypts_of0.78881990

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.26298475
2Distal lower limb muscle weakness (HP:0009053)3.65845774
3Vertebral compression fractures (HP:0002953)3.55183201
4Protrusio acetabuli (HP:0003179)3.31693058
5Distal lower limb amyotrophy (HP:0008944)3.22560239
6Aplastic anemia (HP:0001915)3.14642905
7Abnormality of macrophages (HP:0004311)3.13807586
8Abnormality of liposaccharide metabolism (HP:0010968)3.09218776
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.09218776
10Abnormality of glycolipid metabolism (HP:0010969)3.09218776
11Petechiae (HP:0000967)3.08021102
12J-shaped sella turcica (HP:0002680)3.05654667
13Rough bone trabeculation (HP:0100670)2.70439529
14Distal upper limb amyotrophy (HP:0007149)2.65062076
15Upper limb amyotrophy (HP:0009129)2.65062076
16Increased cerebral lipofuscin (HP:0011813)2.63280705
17Centrally nucleated skeletal muscle fibers (HP:0003687)2.63277897
18Elevated erythrocyte sedimentation rate (HP:0003565)2.55805341
19Atrophic scars (HP:0001075)2.53634229
20Increased IgM level (HP:0003496)2.49795076
21Spinal rigidity (HP:0003306)2.46963064
22Increased neuronal autofluorescent lipopigment (HP:0002074)2.46232957
23Abnormality of the distal phalanges of the toes (HP:0010182)2.43740337
24Dysostosis multiplex (HP:0000943)2.43371612
25Short nail (HP:0001799)2.39421539
26Reduced subcutaneous adipose tissue (HP:0003758)2.38807386
27Increased connective tissue (HP:0009025)2.38431154
28Vacuolated lymphocytes (HP:0001922)2.35418989
29Achilles tendon contracture (HP:0001771)2.34327673
30Increased serum ferritin (HP:0003281)2.33524173
31Osteolytic defects of the hand bones (HP:0009699)2.30372958
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.30372958
33Upper limb muscle weakness (HP:0003484)2.30224240
34Hepatosplenomegaly (HP:0001433)2.28784602
35Purpura (HP:0000979)2.28022547
36Abnormal gallbladder physiology (HP:0012438)2.22801734
37Cholecystitis (HP:0001082)2.22801734
38T lymphocytopenia (HP:0005403)2.22212161
39Generalized amyotrophy (HP:0003700)2.20141976
40Menorrhagia (HP:0000132)2.19949858
41Hyperacusis (HP:0010780)2.18914035
42Autoimmune hemolytic anemia (HP:0001890)2.18835488
43Exercise-induced myalgia (HP:0003738)2.17113929
44Hand muscle atrophy (HP:0009130)2.16215831
45Broad face (HP:0000283)2.15959440
46Nail dystrophy (HP:0008404)2.14870823
47Trismus (HP:0000211)2.13304399
48Abnormality of the Achilles tendon (HP:0005109)2.10008228
49Cervical subluxation (HP:0003308)2.07833969
50Thick nail (HP:0001805)2.07641888
51Difficulty climbing stairs (HP:0003551)2.07106881
52Abnormal trabecular bone morphology (HP:0100671)2.06354689
53Lower limb amyotrophy (HP:0007210)2.04694653
54Fragile skin (HP:0001030)2.02676945
55Hypertriglyceridemia (HP:0002155)2.02513779
56Elbow flexion contracture (HP:0002987)2.02440219
57Abnormality of the umbilical cord (HP:0010881)2.02270451
58Increased mean platelet volume (HP:0011877)2.02259076
59Prolonged neonatal jaundice (HP:0006579)2.01604969
60Abnormality of T cell number (HP:0011839)1.98240867
61Epistaxis (HP:0000421)1.97371425
62Impaired platelet aggregation (HP:0003540)1.96714607
63Abnormal platelet function (HP:0011869)1.96714607
64Abnormal platelet volume (HP:0011876)1.94685852
65Abnormality of skeletal muscle fiber size (HP:0012084)1.94581501
66Nonimmune hydrops fetalis (HP:0001790)1.94021413
67Asymmetric septal hypertrophy (HP:0001670)1.93574988
68Ankle contracture (HP:0006466)1.92095948
69Ragged-red muscle fibers (HP:0003200)1.89769560
70Progressive neurologic deterioration (HP:0002344)1.88180091
71Dilatation of the ascending aorta (HP:0005111)1.84145709
72Fasciculations (HP:0002380)1.82332814
73Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81449868
74Abnormality of polysaccharide metabolism (HP:0011012)1.81449868
75Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81449868
76Blue sclerae (HP:0000592)1.80557777
77Deformed sella turcica (HP:0002681)1.80105099
78Obstructive lung disease (HP:0006536)1.78158545
79Chronic obstructive pulmonary disease (HP:0006510)1.78158545
80Entropion (HP:0000621)1.76144479
81Increased variability in muscle fiber diameter (HP:0003557)1.72795259
82Natal tooth (HP:0000695)1.72141853
83Spastic paraparesis (HP:0002313)1.71859462
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71372664
85Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71372664
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69878302
87Easy fatigability (HP:0003388)1.69532152
88Micronodular cirrhosis (HP:0001413)1.68778493
89Loss of speech (HP:0002371)1.68673227
90Hypertensive crisis (HP:0100735)1.68412527
91Glucose intolerance (HP:0000833)1.67625624
92Onycholysis (HP:0001806)1.67554750
93Abnormality of oral frenula (HP:0000190)1.66676541
94Ureteral stenosis (HP:0000071)1.66673468
95Mucopolysacchariduria (HP:0008155)1.65570759
96Urinary glycosaminoglycan excretion (HP:0003541)1.65570759
97Hypokinesia (HP:0002375)1.64978526
98Acute hepatic failure (HP:0006554)1.64749725
99Myocardial infarction (HP:0001658)1.64179892
100Hyperparathyroidism (HP:0000843)1.63507790

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.91160694
2TESK14.30081371
3IRAK33.90152031
4KDR3.48306752
5EPHA22.96778773
6NME22.87864106
7TRIB32.22957707
8LIMK12.22381475
9ERN11.98220213
10ARAF1.97845230
11PIM21.97483804
12BCKDK1.96517947
13MAPKAPK31.91461214
14SMG11.89889230
15TAOK21.86771133
16VRK21.86044888
17SIK11.85917172
18PAK41.72227320
19MAP3K111.68160450
20MAP4K11.66282643
21MST1R1.65094970
22LMTK21.61557102
23TXK1.56202859
24SCYL21.55242016
25TTN1.50660188
26BUB11.42962188
27MAP3K31.32637048
28PRPF4B1.27451271
29MUSK1.26011733
30TBK11.12328519
31DDR21.11344615
32TAOK11.05753054
33DAPK11.05706694
34ICK1.05191137
35PKN21.01453064
36ZAP701.00402562
37CSK0.90938915
38ITK0.85869764
39PTK20.85662926
40GRK60.85146955
41MYLK0.84158270
42BMX0.81981938
43ABL20.77916439
44CDK80.76349763
45RIPK10.73542480
46ILK0.72981062
47EPHB10.72069649
48MOS0.70490692
49AURKA0.70191010
50STK100.68076394
51MAP2K30.67548863
52PDGFRA0.67076994
53PAK10.66902897
54CSF1R0.66621065
55MAP3K80.66305070
56PRKD20.64993862
57JAK30.61828085
58IRAK40.60787702
59TGFBR20.56967447
60IKBKB0.54821774
61MAPKAPK20.53128262
62CDK70.52080598
63PRKG20.51110724
64MAP3K10.49983223
65CAMK2G0.49516570
66MAPK110.48378874
67TIE10.48198450
68PDPK10.46349274
69GRK70.45967030
70MET0.45541179
71FLT30.45097012
72RPS6KA20.43320958
73IKBKE0.42399395
74NTRK10.42103295
75LRRK20.40611915
76LCK0.38850657
77EPHB20.38587469
78DAPK30.38468621
79SIK30.37446457
80BRAF0.37377590
81BLK0.36222607
82PRKD30.35424144
83MAP3K120.34881934
84MATK0.34181582
85EIF2AK10.33415076
86RPS6KB20.33058340
87FGFR40.31866699
88TYK20.30328091
89PDK10.30209115
90PTK60.29579030
91RAF10.29154244
92MTOR0.29009333
93RIPK40.29007816
94PAK20.28863161
95CDC42BPA0.28636589
96STK380.28401916
97SYK0.27854028
98MAP3K50.27576270
99ROCK10.26995314
100PRKCI0.26855950

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.28589891
2Primary immunodeficiency_Homo sapiens_hsa053403.07745563
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.58139290
4Shigellosis_Homo sapiens_hsa051312.44524412
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.33693312
6Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.27902535
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22034140
8Salmonella infection_Homo sapiens_hsa051322.12087997
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.02647211
10Antigen processing and presentation_Homo sapiens_hsa046121.97895765
11Pentose phosphate pathway_Homo sapiens_hsa000301.85349572
12Other glycan degradation_Homo sapiens_hsa005111.77120459
13Hematopoietic cell lineage_Homo sapiens_hsa046401.74613864
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74353286
15Bladder cancer_Homo sapiens_hsa052191.74327928
16T cell receptor signaling pathway_Homo sapiens_hsa046601.69772943
17Lysosome_Homo sapiens_hsa041421.66417361
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.62524073
19Fructose and mannose metabolism_Homo sapiens_hsa000511.61547878
20Galactose metabolism_Homo sapiens_hsa000521.61492600
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59971836
22Sulfur relay system_Homo sapiens_hsa041221.58299802
23Graft-versus-host disease_Homo sapiens_hsa053321.55666187
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52457908
25Vibrio cholerae infection_Homo sapiens_hsa051101.50870252
26Viral myocarditis_Homo sapiens_hsa054161.46024643
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44369505
28Apoptosis_Homo sapiens_hsa042101.43978774
29Measles_Homo sapiens_hsa051621.36634631
30Rheumatoid arthritis_Homo sapiens_hsa053231.36532076
31Endocytosis_Homo sapiens_hsa041441.34134116
32Biosynthesis of amino acids_Homo sapiens_hsa012301.26275416
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25133088
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.24237818
35Malaria_Homo sapiens_hsa051441.23347324
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22642372
37Autoimmune thyroid disease_Homo sapiens_hsa053201.21553460
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17931099
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16570895
40Allograft rejection_Homo sapiens_hsa053301.16413971
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16308926
42N-Glycan biosynthesis_Homo sapiens_hsa005101.14424467
43TNF signaling pathway_Homo sapiens_hsa046681.11188830
44Prion diseases_Homo sapiens_hsa050201.09754150
45Legionellosis_Homo sapiens_hsa051341.09369657
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08552091
47Focal adhesion_Homo sapiens_hsa045101.06253722
48Pyrimidine metabolism_Homo sapiens_hsa002401.06152774
49Osteoclast differentiation_Homo sapiens_hsa043801.01460150
50Acute myeloid leukemia_Homo sapiens_hsa052211.00539920
51ECM-receptor interaction_Homo sapiens_hsa045120.96825828
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.90195375
53Influenza A_Homo sapiens_hsa051640.85953690
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84363421
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83357299
56Herpes simplex infection_Homo sapiens_hsa051680.83328077
57Chronic myeloid leukemia_Homo sapiens_hsa052200.82388448
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81764376
59HTLV-I infection_Homo sapiens_hsa051660.80736304
60Fatty acid elongation_Homo sapiens_hsa000620.80472269
61DNA replication_Homo sapiens_hsa030300.79637009
62Carbon metabolism_Homo sapiens_hsa012000.79573882
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79189983
64Small cell lung cancer_Homo sapiens_hsa052220.78842338
65Base excision repair_Homo sapiens_hsa034100.77453354
66Toxoplasmosis_Homo sapiens_hsa051450.77339511
67Phagosome_Homo sapiens_hsa041450.77104456
68Chemokine signaling pathway_Homo sapiens_hsa040620.76714032
69Pancreatic cancer_Homo sapiens_hsa052120.75977265
70Epstein-Barr virus infection_Homo sapiens_hsa051690.74346761
71VEGF signaling pathway_Homo sapiens_hsa043700.73013165
72Proteoglycans in cancer_Homo sapiens_hsa052050.72798087
73Platelet activation_Homo sapiens_hsa046110.72482205
74Pertussis_Homo sapiens_hsa051330.70482001
75Steroid biosynthesis_Homo sapiens_hsa001000.70353676
76RNA polymerase_Homo sapiens_hsa030200.68095064
77Thyroid cancer_Homo sapiens_hsa052160.67467287
78Hepatitis C_Homo sapiens_hsa051600.64952988
79Tuberculosis_Homo sapiens_hsa051520.64397943
80Viral carcinogenesis_Homo sapiens_hsa052030.62181377
81Hepatitis B_Homo sapiens_hsa051610.62143957
82Amoebiasis_Homo sapiens_hsa051460.61941006
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61424016
84Sulfur metabolism_Homo sapiens_hsa009200.61109087
85Notch signaling pathway_Homo sapiens_hsa043300.60668571
86Leishmaniasis_Homo sapiens_hsa051400.59622883
87B cell receptor signaling pathway_Homo sapiens_hsa046620.57290696
88Type I diabetes mellitus_Homo sapiens_hsa049400.56451023
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56086274
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.55272907
91Non-small cell lung cancer_Homo sapiens_hsa052230.54793175
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41922805
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41358269
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37197522
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36087612
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35209466
97Glutathione metabolism_Homo sapiens_hsa004800.34403440
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33598354
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33506243
100HIF-1 signaling pathway_Homo sapiens_hsa040660.31078061

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