TMEM189

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.16225271
2central nervous system myelination (GO:0022010)5.16225271
3neutrophil activation involved in immune response (GO:0002283)4.91901490
4positive regulation by symbiont of host defense response (GO:0052509)4.47881165
5modulation by symbiont of host defense response (GO:0052031)4.47881165
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.47881165
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.47881165
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.47881165
9modulation by symbiont of host immune response (GO:0052553)4.47881165
10regulation of cell proliferation involved in kidney development (GO:1901722)4.31177326
11respiratory burst (GO:0045730)4.08423315
12desmosome organization (GO:0002934)4.06296528
13endosome to pigment granule transport (GO:0043485)4.03354097
14endosome to melanosome transport (GO:0035646)4.03354097
15cellular response to ATP (GO:0071318)3.99510455
16regulation of integrin-mediated signaling pathway (GO:2001044)3.82964785
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79157955
18myelin maintenance (GO:0043217)3.70541012
19protein localization to endosome (GO:0036010)3.63061049
20cellular biogenic amine catabolic process (GO:0042402)3.46901535
21amine catabolic process (GO:0009310)3.46901535
22mannosylation (GO:0097502)3.46456198
23positive regulation of triglyceride biosynthetic process (GO:0010867)3.44642173
24ensheathment of neurons (GO:0007272)3.43082768
25axon ensheathment (GO:0008366)3.43082768
26glycosylceramide metabolic process (GO:0006677)3.41007678
27macrophage activation involved in immune response (GO:0002281)3.40689345
28regulation of apoptotic process involved in morphogenesis (GO:1902337)3.38830983
29regulation of interferon-beta biosynthetic process (GO:0045357)3.35464685
30regulation of hippo signaling (GO:0035330)3.33707174
31amyloid precursor protein catabolic process (GO:0042987)3.32424326
32kynurenine metabolic process (GO:0070189)3.29956459
33amyloid precursor protein metabolic process (GO:0042982)3.29302901
34myelination (GO:0042552)3.27579828
35response to lipoprotein particle (GO:0055094)3.25049216
36phagosome maturation (GO:0090382)3.16952339
37granulocyte activation (GO:0036230)3.16893650
38negative regulation of platelet activation (GO:0010544)3.16467908
39indole-containing compound catabolic process (GO:0042436)3.08585358
40indolalkylamine catabolic process (GO:0046218)3.08585358
41tryptophan catabolic process (GO:0006569)3.08585358
42regulation of triglyceride biosynthetic process (GO:0010866)3.08158465
43adhesion of symbiont to host cell (GO:0044650)3.07614784
44virion attachment to host cell (GO:0019062)3.07614784
45angiogenesis involved in wound healing (GO:0060055)3.05874276
46fusion of sperm to egg plasma membrane (GO:0007342)3.04856487
47purinergic nucleotide receptor signaling pathway (GO:0035590)3.04553010
48negative regulation of adherens junction organization (GO:1903392)3.03938741
49negative regulation of focal adhesion assembly (GO:0051895)3.03938741
50negative regulation of cell junction assembly (GO:1901889)3.03938741
51creatine metabolic process (GO:0006600)3.02541197
52neutrophil activation (GO:0042119)3.01028332
53positive regulation of keratinocyte differentiation (GO:0045618)2.99858520
54negative regulation of protein localization to cell surface (GO:2000009)2.99156437
55negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.97904778
56NAD biosynthetic process (GO:0009435)2.92625693
57low-density lipoprotein particle clearance (GO:0034383)2.92313970
58cardiac right ventricle morphogenesis (GO:0003215)2.89730697
59platelet dense granule organization (GO:0060155)2.89404485
60fatty acid elongation (GO:0030497)2.89311898
61GDP-mannose metabolic process (GO:0019673)2.88129460
62myeloid cell activation involved in immune response (GO:0002275)2.86270044
63L-amino acid import (GO:0043092)2.85886169
64membrane raft organization (GO:0031579)2.84814196
65positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.84394224
66cortical actin cytoskeleton organization (GO:0030866)2.83880058
67negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.83124522
68cortical cytoskeleton organization (GO:0030865)2.82237856
69hepatocyte apoptotic process (GO:0097284)2.82041777
70regulation of water loss via skin (GO:0033561)2.80583260
71positive regulation of leukocyte degranulation (GO:0043302)2.76974150
72establishment of skin barrier (GO:0061436)2.75854228
73leukocyte migration involved in inflammatory response (GO:0002523)2.75359336
74positive regulation of prostaglandin secretion (GO:0032308)2.74718508
75nitric oxide biosynthetic process (GO:0006809)2.74664178
76intestinal epithelial cell development (GO:0060576)2.73007792
77response to thyroid hormone (GO:0097066)2.72848227
78negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.70536445
79keratinocyte development (GO:0003334)2.69478053
80glycerophospholipid catabolic process (GO:0046475)2.68924262
81regulation of metalloenzyme activity (GO:0048552)2.67819558
82negative regulation of response to reactive oxygen species (GO:1901032)2.67592748
83regulation of vitamin D biosynthetic process (GO:0060556)2.67314013
84sphingoid metabolic process (GO:0046519)2.66022386
85response to peptidoglycan (GO:0032494)2.65904667
86nucleotide transmembrane transport (GO:1901679)2.65114896
87multicellular organism reproduction (GO:0032504)2.64651209
88dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.64165312
89aromatic amino acid family catabolic process (GO:0009074)2.64125373
90regulation of phospholipid biosynthetic process (GO:0071071)2.62587505
91tyrosine metabolic process (GO:0006570)2.62133841
92long-chain fatty acid biosynthetic process (GO:0042759)2.61851230
93response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.61573227
94response to host immune response (GO:0052572)2.61573227
95regulation of integrin activation (GO:0033623)2.61546466
96hydrogen peroxide biosynthetic process (GO:0050665)2.60798946
97vagina development (GO:0060068)2.60329218
98endothelium development (GO:0003158)2.59559323
99regulation of establishment or maintenance of cell polarity (GO:0032878)2.59164753
100myeloid cell homeostasis (GO:0002262)2.58554823
101aromatic amino acid family metabolic process (GO:0009072)2.57879160
102lipopolysaccharide-mediated signaling pathway (GO:0031663)2.57593796
103response to nerve growth factor (GO:1990089)2.56412266
104cellular response to nerve growth factor stimulus (GO:1990090)2.56412266
105leukocyte aggregation (GO:0070486)2.55660802
106L-phenylalanine metabolic process (GO:0006558)2.55385005
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.55385005
108plasma membrane fusion (GO:0045026)2.53477801
109positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.52362840
110regulation of establishment of cell polarity (GO:2000114)2.50568747
111immunoglobulin mediated immune response (GO:0016064)2.49280294
112cellular response to thyroid hormone stimulus (GO:0097067)2.48303115
113regulation of mononuclear cell migration (GO:0071675)2.48245744
114superoxide anion generation (GO:0042554)2.48022576
115regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.47884132
116negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.47293077
117positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.46548021
118positive regulation of interferon-alpha production (GO:0032727)2.46169241
119regulation of early endosome to late endosome transport (GO:2000641)2.46057814
120regulation of hydrogen peroxide-induced cell death (GO:1903205)2.45711982
121indolalkylamine metabolic process (GO:0006586)2.45222639
122positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.44970916
123response to methylmercury (GO:0051597)2.43835382
124negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.43815152
125negative regulation of cell killing (GO:0031342)2.43815152
126growth hormone receptor signaling pathway (GO:0060396)2.43121741
127regulation of glomerulus development (GO:0090192)2.43059471
128positive regulation of epidermal cell differentiation (GO:0045606)2.42787052
129response to laminar fluid shear stress (GO:0034616)2.42760355
130autophagic vacuole fusion (GO:0000046)2.42438582
131pseudouridine synthesis (GO:0001522)2.41824275
132positive regulation of toll-like receptor signaling pathway (GO:0034123)2.41730303
133positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.41612198
134positive regulation of mast cell activation (GO:0033005)2.40571271
135adenosine receptor signaling pathway (GO:0001973)2.40458072
136purinergic receptor signaling pathway (GO:0035587)2.40457015
137pH reduction (GO:0045851)2.40011789
138adhesion of symbiont to host (GO:0044406)2.39761346
139positive regulation of fatty acid beta-oxidation (GO:0032000)2.39641752
140response to muramyl dipeptide (GO:0032495)2.39394389
141positive regulation of fatty acid oxidation (GO:0046321)2.38729414
142microglial cell activation (GO:0001774)2.38492123
143mast cell activation (GO:0045576)2.38248451
144Rap protein signal transduction (GO:0032486)2.37350009
145positive regulation of antigen processing and presentation (GO:0002579)2.37168342
146regulation of cholesterol storage (GO:0010885)2.37120556
147diol metabolic process (GO:0034311)2.36945138
148protein complex biogenesis (GO:0070271)2.36752931
149regulation of interferon-alpha production (GO:0032647)2.36321136
150tryptophan metabolic process (GO:0006568)2.35850066
151intracellular pH reduction (GO:0051452)2.35037292
152negative regulation of kidney development (GO:0090185)2.33338877
153negative regulation of macroautophagy (GO:0016242)2.32948773
154negative regulation of calcium ion transport into cytosol (GO:0010523)2.31847856
155positive regulation of endothelial cell differentiation (GO:0045603)2.31747048
156positive regulation of hormone metabolic process (GO:0032352)2.31458193
157purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.31244241
1583-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.31244241
159negative regulation of macrophage differentiation (GO:0045650)2.31156876
160positive regulation of odontogenesis (GO:0042482)2.30933407
161positive regulation of p38MAPK cascade (GO:1900745)2.30912428
162negative regulation of keratinocyte proliferation (GO:0010839)2.30551270
163hemidesmosome assembly (GO:0031581)2.30355397
164glutathione biosynthetic process (GO:0006750)2.30097721
165amino acid import (GO:0043090)2.29655147
166regulation of membrane protein ectodomain proteolysis (GO:0051043)2.29558376
167phagocytosis, recognition (GO:0006910)2.29487611
168semaphorin-plexin signaling pathway (GO:0071526)2.29142923
169basic amino acid transport (GO:0015802)2.28379803
170UDP-N-acetylglucosamine metabolic process (GO:0006047)2.27979281
171nonribosomal peptide biosynthetic process (GO:0019184)2.27824764
172behavioral response to nicotine (GO:0035095)2.27633109
173macrophage activation (GO:0042116)2.27234183
174pyridine nucleotide biosynthetic process (GO:0019363)2.27163578
175nicotinamide nucleotide biosynthetic process (GO:0019359)2.27163578
176nodal signaling pathway (GO:0038092)2.26991615
177mitochondrial respiratory chain complex I assembly (GO:0032981)2.26524697
178NADH dehydrogenase complex assembly (GO:0010257)2.26524697
179mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.26524697
180female genitalia development (GO:0030540)2.24952577
181import into cell (GO:0098657)2.24673905
182high-density lipoprotein particle remodeling (GO:0034375)2.24525424
183regulation of nuclear cell cycle DNA replication (GO:0033262)2.24411689
184positive regulation of cAMP-mediated signaling (GO:0043950)2.23577325
185positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.22924256
186negative regulation of cell cycle arrest (GO:0071157)2.22923418
187heterotypic cell-cell adhesion (GO:0034113)2.21907658
188rRNA modification (GO:0000154)2.21859649
189cellular extravasation (GO:0045123)2.21506993
190response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.21093415
191response to host (GO:0075136)2.21093415
192response to host defenses (GO:0052200)2.21093415
193positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.20409252
194activated T cell proliferation (GO:0050798)2.19611261
195peptidyl-tyrosine autophosphorylation (GO:0038083)2.19298483
196positive regulation of macrophage cytokine production (GO:0060907)2.19159526
197neutrophil migration (GO:1990266)2.18931516
198positive regulation of cellular amide metabolic process (GO:0034250)2.17382029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.35295389
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.26250495
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.17727718
4HIF1A_21447827_ChIP-Seq_MCF-7_Human3.78047000
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.24819884
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.19680223
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17893054
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.05493742
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.84063429
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75409444
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35365334
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.33045775
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.25992500
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.25130930
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15986941
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.15878751
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11207409
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11035301
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.05335431
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02621138
21NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.93625438
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.93130535
23* AHR_22903824_ChIP-Seq_MCF-7_Human1.90028176
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79380143
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77116338
26VDR_24787735_ChIP-Seq_THP-1_Human1.73291893
27ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72195054
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71765224
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66798195
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65872994
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65066432
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.63001828
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61037066
34VDR_24763502_ChIP-Seq_THP-1_Human1.59668103
35ATF3_27146783_Chip-Seq_COLON_Human1.57416772
36RUNX_20019798_ChIP-Seq_JUKART_Human1.54235978
37* GATA3_24758297_ChIP-Seq_MCF-7_Human1.54086129
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53889109
39P68_20966046_ChIP-Seq_HELA_Human1.53773657
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.51949823
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.51874352
42* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47725902
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47179410
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46869089
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45753642
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45753642
47SPI1_23127762_ChIP-Seq_K562_Human1.45305850
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45247616
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.44989095
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.43674945
51* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42459970
52BCOR_27268052_Chip-Seq_Bcells_Human1.42049860
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41941433
54* RUNX1_27514584_Chip-Seq_MCF-7_Human1.41909027
55GATA1_19941826_ChIP-Seq_K562_Human1.41743476
56TP53_22127205_ChIP-Seq_IMR90_Human1.41288017
57TP63_22573176_ChIP-Seq_HFKS_Human1.41199079
58* ARNT_22903824_ChIP-Seq_MCF-7_Human1.40690754
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40478121
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40302451
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38639371
62* ERA_21632823_ChIP-Seq_H3396_Human1.38471945
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36335583
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36335583
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35916644
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35449375
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33422026
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32681117
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32418278
70* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31721196
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31476475
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31268087
73GATA4_25053715_ChIP-Seq_YYC3_Human1.30928608
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.30665915
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30273814
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29241245
77E2F1_20622854_ChIP-Seq_HELA_Human1.29225138
78* RXR_22158963_ChIP-Seq_LIVER_Mouse1.28552902
79BCL6_27268052_Chip-Seq_Bcells_Human1.28482634
80EGR1_19032775_ChIP-ChIP_M12_Human1.27176140
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.25353973
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.24603758
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24210161
84CTCF_20526341_ChIP-Seq_ESCs_Human1.24036348
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.23725866
86PU_27001747_Chip-Seq_BMDM_Mouse1.23574856
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23372931
88RACK7_27058665_Chip-Seq_MCF-7_Human1.23107645
89ZNF274_21170338_ChIP-Seq_K562_Hela1.22326678
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21935001
91KDM2B_26808549_Chip-Seq_DND41_Human1.21841124
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21582806
93* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20883856
94SOX2_20726797_ChIP-Seq_SW620_Human1.20796308
95* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19367648
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18972456
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18090087
98VDR_21846776_ChIP-Seq_THP-1_Human1.17588094
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17561154
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17418955
101MAF_26560356_Chip-Seq_TH1_Human1.17221749
102* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15022678
103P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14791632
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14563605
105P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14489312
106* TET1_21451524_ChIP-Seq_MESCs_Mouse1.14041874
107GATA2_19941826_ChIP-Seq_K562_Human1.12794816
108P53_21459846_ChIP-Seq_SAOS-2_Human1.12767933
109* GATA3_21878914_ChIP-Seq_MCF-7_Human1.12712125
110* PHF8_20622854_ChIP-Seq_HELA_Human1.10377204
111LXR_22292898_ChIP-Seq_THP-1_Human1.09691279
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09552991
113TP53_23651856_ChIP-Seq_MEFs_Mouse1.08864956
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08802802
115* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08002397
116* HOXB7_26014856_ChIP-Seq_BT474_Human1.07218988
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06971015
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06578935
119* GATA6_25053715_ChIP-Seq_YYC3_Human1.06514176
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.06251254
121RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06149212
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04914238
123* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04812576
124SPI1_23547873_ChIP-Seq_NB4_Human1.03843003
125P300_27268052_Chip-Seq_Bcells_Human1.03582670
126* RARB_24833708_ChIP-Seq_LIVER_Mouse1.03537262
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03284160
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99950453
129PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98133543
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97642350
131* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97547595
132* PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97487398
133* CJUN_26792858_Chip-Seq_BT549_Human0.96734368
134* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96045791
135* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95780162
136* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95386904
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93948111
138FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93696268
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93418219
140PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92507252
141* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92432671
142* FOXP1_21924763_ChIP-Seq_HESCs_Human0.92145545
143* RAC3_21632823_ChIP-Seq_H3396_Human0.91655990
144PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91303263
145ZNF263_19887448_ChIP-Seq_K562_Human0.91069989
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90975087
147RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90971100
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90851107
149P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.90847008
150* ER_23166858_ChIP-Seq_MCF-7_Human0.90102225
151CDX2_20551321_ChIP-Seq_CACO-2_Human0.89957881
152ERG_21242973_ChIP-ChIP_JURKAT_Human0.89780979
153SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89554903
154KDM2B_26808549_Chip-Seq_K562_Human0.89372371
155NANOG_20526341_ChIP-Seq_ESCs_Human0.88818830
156KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88223232
157RXR_22108803_ChIP-Seq_LS180_Human0.88052516
158SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87976304
159TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87586185
160SRF_21415370_ChIP-Seq_HL-1_Mouse0.87017543
161KLF5_25053715_ChIP-Seq_YYC3_Human0.86917252
162CLOCK_20551151_ChIP-Seq_293T_Human0.86468036
163PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86371370
164SCL_19346495_ChIP-Seq_HPC-7_Human0.86356173
165* MYB_26560356_Chip-Seq_TH2_Human0.86161808
166UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85928032
167ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85884118
168SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85583974
169UBF1/2_26484160_Chip-Seq_HMECs_Human0.85423309
170ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85393711
171TP63_17297297_ChIP-ChIP_HaCaT_Human0.85271066
172ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84002147
173SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83507245
174MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83225720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.99998269
2MP0000920_abnormal_myelination3.80300573
3MP0003303_peritoneal_inflammation3.39106552
4MP0006082_CNS_inflammation3.32563095
5MP0003690_abnormal_glial_cell2.81637441
6MP0003172_abnormal_lysosome_physiology2.78917136
7MP0000383_abnormal_hair_follicle2.71652772
8MP0004381_abnormal_hair_follicle2.65509095
9MP0008875_abnormal_xenobiotic_pharmacok2.58008211
10MP0000604_amyloidosis2.56072408
11MP0003436_decreased_susceptibility_to2.52038431
12MP0002419_abnormal_innate_immunity2.33113701
13MP0004510_myositis2.32182174
14MP0005410_abnormal_fertilization2.25450169
15MP0002796_impaired_skin_barrier2.25212399
16MP0005174_abnormal_tail_pigmentation2.19170324
17MP0005000_abnormal_immune_tolerance2.18825659
18MP0005409_darkened_coat_color2.12146654
19MP0001835_abnormal_antigen_presentation2.11417254
20MP0003329_amyloid_beta_deposits2.10018838
21MP0005501_abnormal_skin_physiology2.07574605
22MP0002148_abnormal_hypersensitivity_rea2.03511045
23MP0005670_abnormal_white_adipose2.01763578
24MP0002089_abnormal_postnatal_growth/wei2.00052230
25MP0009840_abnormal_foam_cell1.96649597
26MP0001958_emphysema1.91973232
27MP0000015_abnormal_ear_pigmentation1.90526170
28MP0002098_abnormal_vibrissa_morphology1.89770689
29MP0003191_abnormal_cellular_cholesterol1.89708410
30MP0003724_increased_susceptibility_to1.87339808
31MP0005025_abnormal_response_to1.87044489
32MP0005387_immune_system_phenotype1.86532526
33MP0001790_abnormal_immune_system1.86532526
34MP0004043_abnormal_pH_regulation1.82597979
35MP0002254_reproductive_system_inflammat1.81167145
36MP0004233_abnormal_muscle_weight1.79957495
37MP0000538_abnormal_urinary_bladder1.78504760
38MP0003300_gastrointestinal_ulcer1.77625697
39MP0005171_absent_coat_pigmentation1.77393857
40MP0008438_abnormal_cutaneous_collagen1.75418310
41MP0003634_abnormal_glial_cell1.74008095
42MP0009785_altered_susceptibility_to1.72654404
43MP0003950_abnormal_plasma_membrane1.72362265
44MP0005365_abnormal_bile_salt1.71607697
45MP0006054_spinal_hemorrhage1.71329712
46MP0005084_abnormal_gallbladder_morpholo1.71139399
47MP0010771_integument_phenotype1.69685202
48MP0003448_altered_tumor_morphology1.69335664
49MP0001533_abnormal_skeleton_physiology1.67797582
50MP0003075_altered_response_to1.66341708
51MP0002452_abnormal_antigen_presenting1.66304709
52MP0002998_abnormal_bone_remodeling1.66194897
53MP0000427_abnormal_hair_cycle1.64135443
54MP0004858_abnormal_nervous_system1.62421697
55MP0005451_abnormal_body_composition1.58718488
56MP0001216_abnormal_epidermal_layer1.58373948
57MP0005023_abnormal_wound_healing1.57795996
58MP0001851_eye_inflammation1.56187388
59MP0001968_abnormal_touch/_nociception1.54952367
60MP0002723_abnormal_immune_serum1.54134717
61MP0000467_abnormal_esophagus_morphology1.54110573
62MP0005464_abnormal_platelet_physiology1.51961401
63MP0000579_abnormal_nail_morphology1.50876778
64MP0008872_abnormal_physiological_respon1.50438383
65MP0003718_maternal_effect1.50117848
66MP0005310_abnormal_salivary_gland1.49750347
67MP0002736_abnormal_nociception_after1.47344924
68MP0005595_abnormal_vascular_smooth1.45641202
69MP0000343_altered_response_to1.45323185
70MP0003011_delayed_dark_adaptation1.43348938
71MP0000685_abnormal_immune_system1.43140421
72MP0003195_calcinosis1.41288679
73MP0004185_abnormal_adipocyte_glucose1.41038776
74MP0002136_abnormal_kidney_physiology1.38777283
75MP0004742_abnormal_vestibular_system1.36110002
76MP0008260_abnormal_autophagy1.35776195
77MP0005167_abnormal_blood-brain_barrier1.35211328
78MP0001819_abnormal_immune_cell1.34921064
79MP0009643_abnormal_urine_homeostasis1.34717385
80MP0000371_diluted_coat_color1.34458578
81MP0002420_abnormal_adaptive_immunity1.34315788
82MP0001800_abnormal_humoral_immune1.33176250
83MP0004947_skin_inflammation1.32350721
84MP0003186_abnormal_redox_activity1.27864392
85MP0000747_muscle_weakness1.25529338
86MP0000377_abnormal_hair_follicle1.24725345
87MP0002138_abnormal_hepatobiliary_system1.22962777
88MP0002933_joint_inflammation1.21891138
89MP0005166_decreased_susceptibility_to1.21756945
90MP0001845_abnormal_inflammatory_respons1.21207963
91MP0000003_abnormal_adipose_tissue1.19228915
92MP0002877_abnormal_melanocyte_morpholog1.19201798
93MP0005671_abnormal_response_to1.14817105
94MP0008469_abnormal_protein_level1.14286305
95MP0000470_abnormal_stomach_morphology1.14243277
96MP0003656_abnormal_erythrocyte_physiolo1.13160265
97MP0002060_abnormal_skin_morphology1.12933342
98MP0002405_respiratory_system_inflammati1.12886516
99MP0010386_abnormal_urinary_bladder1.12751820
100MP0003638_abnormal_response/metabolism_1.12527087
101MP0000367_abnormal_coat/_hair1.11239201
102MP0005332_abnormal_amino_acid1.09782784
103MP0005257_abnormal_intraocular_pressure1.08997846
104MP0001879_abnormal_lymphatic_vessel1.08594113
105MP0009931_abnormal_skin_appearance1.07755446
106MP0005551_abnormal_eye_electrophysiolog1.04487852
107MP0001756_abnormal_urination1.04177410
108MP0010368_abnormal_lymphatic_system1.04169820
109MP0010030_abnormal_orbit_morphology1.03871307
110MP0005076_abnormal_cell_differentiation1.03445029
111MP0000750_abnormal_muscle_regeneration1.02786610
112MP0005164_abnormal_response_to1.01971291
113MP0001765_abnormal_ion_homeostasis1.01906211
114MP0000647_abnormal_sebaceous_gland1.01458946
115MP0005165_increased_susceptibility_to1.01121779
116MP0003806_abnormal_nucleotide_metabolis1.01109376
117MP0003705_abnormal_hypodermis_morpholog1.00174263
118MP0000358_abnormal_cell_content/0.99228786
119MP0003566_abnormal_cell_adhesion0.99204990
120MP0002837_dystrophic_cardiac_calcinosis0.98276257
121MP0001919_abnormal_reproductive_system0.97977458
122MP0005389_reproductive_system_phenotype0.97417170
123MP0003453_abnormal_keratinocyte_physiol0.97076333
124MP0002160_abnormal_reproductive_system0.96313863
125MP0001873_stomach_inflammation0.95925894
126MP0000230_abnormal_systemic_arterial0.93847675
127MP0003633_abnormal_nervous_system0.93453143
128MP0005083_abnormal_biliary_tract0.92335890
129MP0004272_abnormal_basement_membrane0.90783695
130MP0005408_hypopigmentation0.90780657
131MP0000372_irregular_coat_pigmentation0.89558421
132MP0000733_abnormal_muscle_development0.89028511
133MP0009333_abnormal_splenocyte_physiolog0.88553770
134MP0002295_abnormal_pulmonary_circulatio0.85949246
135MP0004133_heterotaxia0.85326304
136MP0009764_decreased_sensitivity_to0.84943016
137MP0003941_abnormal_skin_development0.83363586
138MP0005584_abnormal_enzyme/coenzyme_acti0.82626909
139MP0001191_abnormal_skin_condition0.81921937
140MP0000716_abnormal_immune_system0.81913648
141MP0000767_abnormal_smooth_muscle0.81019788
142MP0004885_abnormal_endolymph0.80930636
143MP0010678_abnormal_skin_adnexa0.79439164
144MP0003136_yellow_coat_color0.79268764
145MP0005636_abnormal_mineral_homeostasis0.78704795
146MP0002075_abnormal_coat/hair_pigmentati0.78641072
147MP0004019_abnormal_vitamin_homeostasis0.78007432
148MP0004264_abnormal_extraembryonic_tissu0.77891762
149MP0010155_abnormal_intestine_physiology0.77016339
150MP0005623_abnormal_meninges_morphology0.76857896
151MP0002229_neurodegeneration0.75274184
152MP0003631_nervous_system_phenotype0.74414260
153MP0003091_abnormal_cell_migration0.73806526
154MP0008004_abnormal_stomach_pH0.73120518
155MP0003632_abnormal_nervous_system0.72649004
156MP0001186_pigmentation_phenotype0.72214039
157MP0001663_abnormal_digestive_system0.71772765
158MP0005075_abnormal_melanosome_morpholog0.71461236
159MP0005647_abnormal_sex_gland0.70890951
160MP0003795_abnormal_bone_structure0.70885446
161MP0010329_abnormal_lipoprotein_level0.69926042
162MP0002332_abnormal_exercise_endurance0.69923206
163MP0002653_abnormal_ependyma_morphology0.69485918
164MP0000249_abnormal_blood_vessel0.69092851
165MP0009278_abnormal_bone_marrow0.68590917
166MP0003828_pulmonary_edema0.68540192
167MP0005666_abnormal_adipose_tissue0.67761465
168MP0005390_skeleton_phenotype0.67405908
169MP0005388_respiratory_system_phenotype0.67367916
170MP0002133_abnormal_respiratory_system0.67367916
171MP0002118_abnormal_lipid_homeostasis0.65933177
172MP0000858_altered_metastatic_potential0.64977502
173MP0001324_abnormal_eye_pigmentation0.64913995
174MP0005395_other_phenotype0.64706918
175MP0002090_abnormal_vision0.64458310
176MP0005377_hearing/vestibular/ear_phenot0.63051503

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.05148287
2Axonal loss (HP:0003447)4.99844945
3Increased cerebral lipofuscin (HP:0011813)4.84059467
4Abnormality of macrophages (HP:0004311)4.76264922
5Eczematoid dermatitis (HP:0000976)4.49429580
6Recurrent abscess formation (HP:0002722)4.48392535
7Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.43487127
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.23272435
9Segmental peripheral demyelination/remyelination (HP:0003481)4.22784582
10Neurofibrillary tangles (HP:0002185)4.13122423
11Recurrent bacterial skin infections (HP:0005406)4.09590336
12Type II lissencephaly (HP:0007260)3.92350979
13Dysostosis multiplex (HP:0000943)3.74967129
14Metabolic alkalosis (HP:0200114)3.69011826
15Hypomagnesemia (HP:0002917)3.61289600
16Peripheral hypomyelination (HP:0007182)3.59403967
17Hypokalemic alkalosis (HP:0001949)3.49230228
18Recurrent gram-negative bacterial infections (HP:0005420)3.48747348
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.36687940
20Abnormality of glycolipid metabolism (HP:0010969)3.36687940
21Abnormality of liposaccharide metabolism (HP:0010968)3.36687940
22Increased circulating renin level (HP:0000848)3.36212788
23Cerebral inclusion bodies (HP:0100314)3.12980447
24Abnormality of magnesium homeostasis (HP:0004921)3.10498379
25Amelogenesis imperfecta (HP:0000705)3.09575549
26Cerebellar dysplasia (HP:0007033)3.06217319
27Loss of speech (HP:0002371)3.05606031
28Concave nail (HP:0001598)3.04922564
29Peripheral demyelination (HP:0011096)3.03562138
30Supranuclear gaze palsy (HP:0000605)3.03161239
31Degeneration of the lateral corticospinal tracts (HP:0002314)3.00965106
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.00965106
33Menorrhagia (HP:0000132)2.99485868
34Disinhibition (HP:0000734)2.98171692
35Hypophosphatemic rickets (HP:0004912)2.94450355
36Abnormality of chloride homeostasis (HP:0011422)2.93342705
37Onion bulb formation (HP:0003383)2.92266955
38Urinary glycosaminoglycan excretion (HP:0003541)2.86494638
39Mucopolysacchariduria (HP:0008155)2.86494638
40Congenital stationary night blindness (HP:0007642)2.86026946
41Congenital, generalized hypertrichosis (HP:0004540)2.83413837
42Petechiae (HP:0000967)2.80925648
43Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.77375044
44Stomatitis (HP:0010280)2.73570812
45Termporal pattern (HP:0011008)2.72547163
46Insidious onset (HP:0003587)2.72547163
47Attenuation of retinal blood vessels (HP:0007843)2.66043086
48Obstructive lung disease (HP:0006536)2.65745708
49Chronic obstructive pulmonary disease (HP:0006510)2.65745708
50Tetany (HP:0001281)2.62947028
51Recurrent skin infections (HP:0001581)2.62680075
52Abnormality of polysaccharide metabolism (HP:0011012)2.60492132
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60492132
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60492132
55Systemic lupus erythematosus (HP:0002725)2.58323232
56Hepatosplenomegaly (HP:0001433)2.57924753
57Septate vagina (HP:0001153)2.53911393
58Disproportionate short-trunk short stature (HP:0003521)2.51195528
59Renal Fanconi syndrome (HP:0001994)2.47160085
60Muscle fiber splitting (HP:0003555)2.47000772
61Hyperalaninemia (HP:0003348)2.46471081
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46471081
63Abnormality of alanine metabolism (HP:0010916)2.46471081
64Polyuria (HP:0000103)2.44111421
65Autoimmune thrombocytopenia (HP:0001973)2.43130297
66Generalized aminoaciduria (HP:0002909)2.43130134
67Ulnar claw (HP:0001178)2.41218128
68Keratoconus (HP:0000563)2.39510164
69Increased corneal curvature (HP:0100692)2.39510164
70Severe muscular hypotonia (HP:0006829)2.38870352
71Prolonged bleeding time (HP:0003010)2.38150608
72Poikiloderma (HP:0001029)2.32771219
73Hyperactive renin-angiotensin system (HP:0000841)2.32559131
74Testicular atrophy (HP:0000029)2.31403611
75Interstitial pulmonary disease (HP:0006530)2.29524829
76Mediastinal lymphadenopathy (HP:0100721)2.28741007
77Abnormal urine output (HP:0012590)2.26149287
78Prolonged neonatal jaundice (HP:0006579)2.23645893
79Gingivitis (HP:0000230)2.21870444
80Sparse eyelashes (HP:0000653)2.21351825
81Parakeratosis (HP:0001036)2.20651742
82Increased CSF protein (HP:0002922)2.18663321
83Abnormality of renal excretion (HP:0011036)2.17624522
84J-shaped sella turcica (HP:0002680)2.17200124
85Osteolytic defects of the phalanges of the hand (HP:0009771)2.14146379
86Osteolytic defects of the hand bones (HP:0009699)2.14146379
87Stridor (HP:0010307)2.13910033
88Renal salt wasting (HP:0000127)2.13884444
89Bulbous nose (HP:0000414)2.13841313
90Abnormality of the corticospinal tract (HP:0002492)2.13440932
91Cellulitis (HP:0100658)2.11076314
92Abnormality of dental color (HP:0011073)2.10688311
93Vascular calcification (HP:0004934)2.09208372
94Type I transferrin isoform profile (HP:0003642)2.09105806
95Neuronal loss in central nervous system (HP:0002529)2.06959635
96Hyperlipoproteinemia (HP:0010980)2.03478514
97Anterior segment dysgenesis (HP:0007700)2.02201201
98Foot dorsiflexor weakness (HP:0009027)2.01963738
99Opisthotonus (HP:0002179)2.01191667
100Alopecia of scalp (HP:0002293)2.00774106
101Lissencephaly (HP:0001339)2.00761446
102Increased mean platelet volume (HP:0011877)2.00312978
103Abnormal drinking behavior (HP:0030082)1.99281371
104Polydipsia (HP:0001959)1.99281371
105Abnormality of transition element cation homeostasis (HP:0011030)1.98540910
106Pendular nystagmus (HP:0012043)1.96757506
107Increased serum ferritin (HP:0003281)1.95403701
108Abnormality of the nasal septum (HP:0000419)1.95203502
109Chorioretinal atrophy (HP:0000533)1.94613155
110Slow saccadic eye movements (HP:0000514)1.93572906
111Entropion (HP:0000621)1.93378466
112Juvenile onset (HP:0003621)1.92835743
113Congenital sensorineural hearing impairment (HP:0008527)1.92825504
114Akinesia (HP:0002304)1.92187904
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91863711
116Elevated erythrocyte sedimentation rate (HP:0003565)1.91728453
117Microretrognathia (HP:0000308)1.90470738
118Hyperventilation (HP:0002883)1.90138338
119Clumsiness (HP:0002312)1.89687047
120Apathy (HP:0000741)1.88546585
121Decreased central vision (HP:0007663)1.88482265
122Cardiovascular calcification (HP:0011915)1.88449303
123Aplasia of the musculature (HP:0100854)1.88292671
124Pathologic fracture (HP:0002756)1.87725943
125Purpura (HP:0000979)1.86600439
126Severe visual impairment (HP:0001141)1.86343936
127Spastic tetraparesis (HP:0001285)1.85828888
128Abnormality of the neuromuscular junction (HP:0003398)1.85539094
129Fatigable weakness (HP:0003473)1.85539094
130Glomerulonephritis (HP:0000099)1.85524353
131Hypoplasia of the iris (HP:0007676)1.85108519
132Abnormality of proline metabolism (HP:0010907)1.84756928
133Hydroxyprolinuria (HP:0003080)1.84756928
134Urticaria (HP:0001025)1.84116895
135Popliteal pterygium (HP:0009756)1.83276518
136Buphthalmos (HP:0000557)1.82661334
137Tongue fasciculations (HP:0001308)1.82638420
138Sensory axonal neuropathy (HP:0003390)1.81505411
139Diminished motivation (HP:0000745)1.81028104
140Thick nail (HP:0001805)1.79251941
141Hyperaldosteronism (HP:0000859)1.79061102
142Cerebral hemorrhage (HP:0001342)1.78467522
143Fragile nails (HP:0001808)1.77777512
144Amyloidosis (HP:0011034)1.77582780
145Abnormality of the lumbar spine (HP:0100712)1.74114654
146Abnormality of renin-angiotensin system (HP:0000847)1.73941778
147Retinal dysplasia (HP:0007973)1.73916163
148Polymicrogyria (HP:0002126)1.73741252
149Squamous cell carcinoma (HP:0002860)1.72616804
150Abnormality of the foot musculature (HP:0001436)1.72539691
151Xanthomatosis (HP:0000991)1.72075308
152Lip pit (HP:0100267)1.71956580
153Hypoplasia of the odontoid process (HP:0003311)1.71284240
154Hepatic necrosis (HP:0002605)1.71172593
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70886996
156Abnormal protein N-linked glycosylation (HP:0012347)1.70886996
157Abnormal protein glycosylation (HP:0012346)1.70886996
158Abnormal glycosylation (HP:0012345)1.70886996
159Abnormality of DNA repair (HP:0003254)1.69287517
160Abnormal auditory evoked potentials (HP:0006958)1.69226686
161Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.68921514
162Esophageal varix (HP:0002040)1.68015083
163Long toe (HP:0010511)1.67390588
164Paralysis (HP:0003470)1.67345174
165Alkalosis (HP:0001948)1.67185358
166Gastrointestinal stroma tumor (HP:0100723)1.67102531
167Ureteral duplication (HP:0000073)1.66076779
168Recurrent fungal infections (HP:0002841)1.65900715
169Myocardial infarction (HP:0001658)1.65763218
170Absent thumb (HP:0009777)1.64508354
171Mesangial abnormality (HP:0001966)1.64276569
172Hammertoe (HP:0001765)1.64197508
173Abnormal platelet function (HP:0011869)1.63965024
174Impaired platelet aggregation (HP:0003540)1.63965024
175Ileus (HP:0002595)1.63603880
176Focal segmental glomerulosclerosis (HP:0000097)1.63522248
177Abnormality of iron homeostasis (HP:0011031)1.62670681
178Short femoral neck (HP:0100864)1.62146746
179Cutaneous melanoma (HP:0012056)1.61932611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.32705463
2FRK4.06346239
3EPHB13.88034315
4OXSR13.67964065
5WNK43.46080705
6MAPKAPK33.45217743
7EPHA23.23176029
8RIPK43.06141177
9PBK2.75669961
10BLK2.64558562
11ADRBK22.51518021
12BMPR1B2.46168732
13MUSK2.42146450
14ACVR1B2.39919459
15VRK22.35733718
16TBK12.19766645
17KSR21.93885755
18MST41.92135467
19SIK11.87369643
20MET1.86315856
21MST1R1.79471910
22BMX1.77929175
23INSRR1.77005978
24LMTK21.76516181
25TLK11.74162392
26MAP3K141.73020819
27WNK11.71961770
28MAP4K11.67591430
29TESK21.63787846
30NUAK11.61818646
31GRK11.59882897
32FGR1.58698835
33TIE11.56200935
34ADRBK11.52879005
35TGFBR11.51112055
36WNK31.40843691
37ERN11.38609131
38MAP3K131.38366988
39EIF2AK11.36307069
40ILK1.33033311
41SIK31.32535360
42LIMK11.30637036
43PKN11.28075518
44EPHB21.27788380
45LRRK21.24102987
46ZAK1.23654422
47MAP2K11.22844609
48NME21.21451476
49KIT1.21061038
50ABL21.18665410
51TRIB31.18248405
52CSK1.18217636
53TRIM281.17457963
54IKBKE1.16875130
55FER1.16702329
56RPS6KB21.16560859
57NTRK11.14076964
58TYK21.13298091
59MELK1.12527487
60FLT31.10051975
61PDPK11.09768804
62STK101.08802751
63MAPKAPK51.07878201
64MAP3K31.04761535
65CHUK1.04076808
66TAOK31.03268396
67MAP2K21.00895578
68PRKD21.00385223
69IKBKB0.99992069
70PRKCI0.99492262
71IRAK40.95984288
72MAP3K20.92667456
73PIK3CA0.92352416
74PAK60.91086872
75CDK80.90544524
76PTK2B0.87757786
77FES0.84849301
78CAMK1D0.84123895
79LCK0.83739631
80HCK0.82621211
81CAMK1G0.81981528
82JAK10.81828613
83CLK10.80577409
84ARAF0.79736178
85MOS0.79569794
86PDGFRB0.78108070
87ITK0.77677949
88MARK30.76292714
89PDK10.75449552
90JAK20.75201731
91ROCK20.75169446
92CSF1R0.74346174
93GRK50.73828910
94STK380.73616797
95SMG10.72916879
96TGFBR20.72871650
97NEK90.72633206
98MYLK0.71986620
99GSK3A0.71426555
100DAPK20.70477809
101TTN0.70378234
102PRKD10.69343040
103IRAK30.67951064
104PIM20.67902926
105MAP3K10.67642354
106ABL10.67088059
107TRPM70.66483436
108MAP4K20.66371996
109STK30.66101888
110TESK10.65668952
111ZAP700.64862798
112RET0.64686483
113SYK0.62494784
114DAPK30.61343694
115PRKG20.60215377
116ERBB40.59639762
117GRK60.59594965
118PRKCE0.59537579
119EGFR0.59201614
120FYN0.58253931
121TAF10.58163350
122PRKCQ0.58121159
123PAK40.57448014
124DDR20.57229425
125NME10.56795665
126PRKCH0.56296935
127PTK60.54098754
128RPS6KA20.53727868
129ICK0.52992775
130HIPK20.52766451
131MAP3K110.52337450
132TAOK20.52022873
133LYN0.51813610
134GRK70.51721462
135PRKD30.50571816
136CAMK2D0.48573395
137MATK0.47908195
138DAPK10.47761269
139CSNK1G30.47723352
140PRKCD0.46202507
141CSNK1A1L0.45972116
142SGK2230.45502365
143SGK4940.45502365
144MAPK110.45307951
145LATS20.45081307
146PTK20.44903911
147MTOR0.44277367
148TYRO30.43938980
149BTK0.43156563
150SRC0.41834132
151PKN20.40802659
152CDC42BPA0.40545493
153PDK20.40103132
154CDK90.40075715
155SCYL20.39985264
156INSR0.39266853
157DMPK0.38603116
158JAK30.38541389
159BCR0.38231531
160TAOK10.36891193
161STK38L0.34904959
162CAMK2G0.33528188
163PRKAA20.32075604
164MAPKAPK20.31590941
165PHKG20.30609102

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.74435904
2Lysosome_Homo sapiens_hsa041423.22673623
3Steroid biosynthesis_Homo sapiens_hsa001002.74049254
4Collecting duct acid secretion_Homo sapiens_hsa049662.61702190
5Sulfur relay system_Homo sapiens_hsa041222.54085243
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.53574090
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.38473009
8RNA polymerase_Homo sapiens_hsa030202.25921775
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12904567
10Other glycan degradation_Homo sapiens_hsa005112.12237309
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10520328
12Rheumatoid arthritis_Homo sapiens_hsa053232.02836632
13Leishmaniasis_Homo sapiens_hsa051401.96843078
14Phagosome_Homo sapiens_hsa041451.96132377
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.92096763
16Bladder cancer_Homo sapiens_hsa052191.87859551
17Nitrogen metabolism_Homo sapiens_hsa009101.85485759
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84708290
19Osteoclast differentiation_Homo sapiens_hsa043801.80603732
20Malaria_Homo sapiens_hsa051441.74703876
21Staphylococcus aureus infection_Homo sapiens_hsa051501.74124985
22Tuberculosis_Homo sapiens_hsa051521.66074332
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63081000
24N-Glycan biosynthesis_Homo sapiens_hsa005101.61596976
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59247668
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.58624245
27Mineral absorption_Homo sapiens_hsa049781.56006347
28Sphingolipid metabolism_Homo sapiens_hsa006001.55491063
29Pertussis_Homo sapiens_hsa051331.50205669
30Ether lipid metabolism_Homo sapiens_hsa005651.46457755
31Salmonella infection_Homo sapiens_hsa051321.45569216
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44571140
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44227817
34B cell receptor signaling pathway_Homo sapiens_hsa046621.41578338
35Ovarian steroidogenesis_Homo sapiens_hsa049131.39831151
36Phototransduction_Homo sapiens_hsa047441.31558247
37Graft-versus-host disease_Homo sapiens_hsa053321.31356393
38Glycerolipid metabolism_Homo sapiens_hsa005611.30846419
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.29556594
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.27322835
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26566876
42Renal cell carcinoma_Homo sapiens_hsa052111.25876482
43Fatty acid elongation_Homo sapiens_hsa000621.25645435
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15837844
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15318420
46Vitamin B6 metabolism_Homo sapiens_hsa007501.15309939
47Selenocompound metabolism_Homo sapiens_hsa004501.13980621
48Melanoma_Homo sapiens_hsa052181.12130307
49Tryptophan metabolism_Homo sapiens_hsa003801.10028388
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08600536
51Sphingolipid signaling pathway_Homo sapiens_hsa040711.08149261
52Dorso-ventral axis formation_Homo sapiens_hsa043201.08108562
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07173173
54Endocytosis_Homo sapiens_hsa041441.06765972
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05702485
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02988021
57Amoebiasis_Homo sapiens_hsa051461.02201916
58Sulfur metabolism_Homo sapiens_hsa009200.99108000
59Shigellosis_Homo sapiens_hsa051310.98635061
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96615239
61Chemokine signaling pathway_Homo sapiens_hsa040620.96300449
62Toxoplasmosis_Homo sapiens_hsa051450.95828374
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95170405
64TGF-beta signaling pathway_Homo sapiens_hsa043500.94683995
65Vibrio cholerae infection_Homo sapiens_hsa051100.94092514
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.91867882
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90752411
68Basal transcription factors_Homo sapiens_hsa030220.89849198
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.89711395
70Asthma_Homo sapiens_hsa053100.89502231
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87716678
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.87606653
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87141215
74Arachidonic acid metabolism_Homo sapiens_hsa005900.86874113
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86389675
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85038223
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.81412606
78Histidine metabolism_Homo sapiens_hsa003400.81155413
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80684353
80Linoleic acid metabolism_Homo sapiens_hsa005910.78423385
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.77945267
82Apoptosis_Homo sapiens_hsa042100.77860453
83ABC transporters_Homo sapiens_hsa020100.77512985
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77060028
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76790625
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76392660
87Small cell lung cancer_Homo sapiens_hsa052220.76226676
88Hepatitis C_Homo sapiens_hsa051600.76053385
89Hematopoietic cell lineage_Homo sapiens_hsa046400.75623194
90VEGF signaling pathway_Homo sapiens_hsa043700.73758074
91Fructose and mannose metabolism_Homo sapiens_hsa000510.72207871
92Hippo signaling pathway_Homo sapiens_hsa043900.71983755
93Proteasome_Homo sapiens_hsa030500.70479623
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69869463
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.69839586
96Legionellosis_Homo sapiens_hsa051340.67838388
97PPAR signaling pathway_Homo sapiens_hsa033200.67273895
98TNF signaling pathway_Homo sapiens_hsa046680.66621684
99Pyrimidine metabolism_Homo sapiens_hsa002400.65611738
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64397610
101Pancreatic cancer_Homo sapiens_hsa052120.64245614
102Platelet activation_Homo sapiens_hsa046110.62655494
103Oxidative phosphorylation_Homo sapiens_hsa001900.62405449
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62360107
105Glutathione metabolism_Homo sapiens_hsa004800.61859606
106Autoimmune thyroid disease_Homo sapiens_hsa053200.61436821
107Allograft rejection_Homo sapiens_hsa053300.61292383
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60469935
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60465070
110Metabolic pathways_Homo sapiens_hsa011000.60367065
111Homologous recombination_Homo sapiens_hsa034400.59659651
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58663118
113T cell receptor signaling pathway_Homo sapiens_hsa046600.58289432
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56362966
115Butanoate metabolism_Homo sapiens_hsa006500.56356796
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.55608302
117Measles_Homo sapiens_hsa051620.55518219
118Prion diseases_Homo sapiens_hsa050200.55511756
119Vitamin digestion and absorption_Homo sapiens_hsa049770.54625191
120ECM-receptor interaction_Homo sapiens_hsa045120.51416980
121Gastric acid secretion_Homo sapiens_hsa049710.50557289
122Choline metabolism in cancer_Homo sapiens_hsa052310.50510088
123Viral myocarditis_Homo sapiens_hsa054160.50349654
124Acute myeloid leukemia_Homo sapiens_hsa052210.50200186
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49992770
126Peroxisome_Homo sapiens_hsa041460.49184754
127Chemical carcinogenesis_Homo sapiens_hsa052040.48973581
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.48930504
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.47987754
130Proteoglycans in cancer_Homo sapiens_hsa052050.47675769
131Galactose metabolism_Homo sapiens_hsa000520.47201359
132Focal adhesion_Homo sapiens_hsa045100.47183475
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46406037
134Insulin resistance_Homo sapiens_hsa049310.46157573
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.45729275
136beta-Alanine metabolism_Homo sapiens_hsa004100.45633657
137Fat digestion and absorption_Homo sapiens_hsa049750.45066688
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44117009
139Antigen processing and presentation_Homo sapiens_hsa046120.43200258
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43032359
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42472523
142Complement and coagulation cascades_Homo sapiens_hsa046100.41634694
143Chronic myeloid leukemia_Homo sapiens_hsa052200.41448511
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40170721
145Protein digestion and absorption_Homo sapiens_hsa049740.39715062
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.39449934
147Renin-angiotensin system_Homo sapiens_hsa046140.39438800
148Purine metabolism_Homo sapiens_hsa002300.38194612
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37993987
150Influenza A_Homo sapiens_hsa051640.37584630
151Huntingtons disease_Homo sapiens_hsa050160.37343920
152Parkinsons disease_Homo sapiens_hsa050120.34761900
153Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33191103
154Serotonergic synapse_Homo sapiens_hsa047260.33142700
155Fatty acid biosynthesis_Homo sapiens_hsa000610.32506323
156p53 signaling pathway_Homo sapiens_hsa041150.31710952
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31674381
158Tight junction_Homo sapiens_hsa045300.29114708
159Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25800442

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