TMEM18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)7.91948705
2positive regulation of respiratory burst (GO:0060267)6.13052772
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.98956395
4presynaptic membrane assembly (GO:0097105)5.86915188
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.31528628
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.16404023
7ATP synthesis coupled proton transport (GO:0015986)5.16404023
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.95885114
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.93136643
10membrane assembly (GO:0071709)4.83524576
11protein complex biogenesis (GO:0070271)4.75245679
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.65070533
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.65070533
14NADH dehydrogenase complex assembly (GO:0010257)4.65070533
15mitochondrial respiratory chain complex assembly (GO:0033108)4.54078462
16proteasome assembly (GO:0043248)4.53300218
17respiratory electron transport chain (GO:0022904)4.50474000
18electron transport chain (GO:0022900)4.45189557
19chaperone-mediated protein transport (GO:0072321)4.32488573
20peptidyl-tyrosine autophosphorylation (GO:0038083)4.24132059
21regulation of mitochondrial translation (GO:0070129)4.16408916
22rRNA modification (GO:0000154)4.15314571
23CENP-A containing nucleosome assembly (GO:0034080)4.04647992
24ribosomal small subunit assembly (GO:0000028)4.02744013
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.02553705
26chromatin remodeling at centromere (GO:0031055)4.02496040
27viral transcription (GO:0019083)4.01780051
28translational termination (GO:0006415)4.01305859
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.01212450
30protein localization to endosome (GO:0036010)3.98529809
31cotranslational protein targeting to membrane (GO:0006613)3.91044732
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90849908
33respiratory chain complex IV assembly (GO:0008535)3.89313126
34replication fork processing (GO:0031297)3.88465659
35barbed-end actin filament capping (GO:0051016)3.87154248
36protein targeting to ER (GO:0045047)3.83852073
37locomotory exploration behavior (GO:0035641)3.82729647
38ribosomal small subunit biogenesis (GO:0042274)3.80646293
39maturation of SSU-rRNA (GO:0030490)3.78603991
40termination of RNA polymerase III transcription (GO:0006386)3.77583602
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.77583602
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.77341241
43alanine transport (GO:0032328)3.72332286
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.67005105
45opsonization (GO:0008228)3.66835364
46protein localization to endoplasmic reticulum (GO:0070972)3.65972573
47ribosomal large subunit biogenesis (GO:0042273)3.59629437
48cytochrome complex assembly (GO:0017004)3.56879506
49synaptic vesicle exocytosis (GO:0016079)3.55013339
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.52468389
51rRNA methylation (GO:0031167)3.48931132
52cullin deneddylation (GO:0010388)3.48914321
53sodium ion export (GO:0071436)3.46209154
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45539238
55proline transport (GO:0015824)3.45128358
56translational elongation (GO:0006414)3.43280900
57pseudouridine synthesis (GO:0001522)3.42700220
58protein neddylation (GO:0045116)3.41869690
59gamma-aminobutyric acid transport (GO:0015812)3.39016331
60prepulse inhibition (GO:0060134)3.38112947
61translation (GO:0006412)3.37578331
62protein targeting to mitochondrion (GO:0006626)3.37444125
63synaptic transmission, glutamatergic (GO:0035249)3.35350110
64negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33410138
65protein-cofactor linkage (GO:0018065)3.32865800
66alpha-linolenic acid metabolic process (GO:0036109)3.31074842
67histone exchange (GO:0043486)3.27863279
68glutamate secretion (GO:0014047)3.27777923
69inositol phosphate dephosphorylation (GO:0046855)3.26926466
70phosphorylated carbohydrate dephosphorylation (GO:0046838)3.26926466
71translational initiation (GO:0006413)3.24126794
72GTP biosynthetic process (GO:0006183)3.23880684
73kinetochore assembly (GO:0051382)3.22710753
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20005042
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18405373
76centriole replication (GO:0007099)3.15394215
77intracellular protein transmembrane import (GO:0044743)3.14805987
78protein localization to mitochondrion (GO:0070585)3.14669792
79kinetochore organization (GO:0051383)3.13250218
807-methylguanosine mRNA capping (GO:0006370)3.13111962
81positive regulation of macrophage cytokine production (GO:0060907)3.12609746
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12604126
83establishment of protein localization to mitochondrion (GO:0072655)3.11423227
84protein deneddylation (GO:0000338)3.11421879
85purine nucleoside triphosphate biosynthetic process (GO:0009145)3.11030769
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09528762
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08114421
88regulation of mitotic spindle checkpoint (GO:1903504)3.07829875
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07829875
90establishment of integrated proviral latency (GO:0075713)3.07533552
91negative regulation of ligase activity (GO:0051352)3.07415600
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07415600
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05731998
94purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.05659203
95telomere maintenance via semi-conservative replication (GO:0032201)3.05451101
96spliceosomal snRNP assembly (GO:0000387)3.05156812
97inositol phosphate catabolic process (GO:0071545)3.05022756
98histone H3-K36 demethylation (GO:0070544)3.04818639
99cellular component biogenesis (GO:0044085)3.04786889
100resolution of meiotic recombination intermediates (GO:0000712)3.04481580
1017-methylguanosine RNA capping (GO:0009452)3.03881014
102RNA capping (GO:0036260)3.03881014
103peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.02651265
104viral life cycle (GO:0019058)3.02265481
105positive regulation of glycogen biosynthetic process (GO:0045725)3.02052133
106necroptotic process (GO:0070266)3.00942761
107ATP biosynthetic process (GO:0006754)2.99905051
108nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99080282
109neuron-neuron synaptic transmission (GO:0007270)2.98351567
110histone mRNA metabolic process (GO:0008334)2.97691241
111glutamate receptor signaling pathway (GO:0007215)2.97255532
112neurotransmitter-gated ion channel clustering (GO:0072578)2.97183295
113cellular protein complex disassembly (GO:0043624)2.97030446
114rRNA processing (GO:0006364)2.96914257
115erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.96861992
116L-phenylalanine catabolic process (GO:0006559)2.96861992
117positive regulation of dendrite morphogenesis (GO:0050775)2.95132526
118negative regulation of sodium ion transport (GO:0010766)2.94996241
119transcription-coupled nucleotide-excision repair (GO:0006283)2.94601875
120pyrimidine nucleotide catabolic process (GO:0006244)2.93904781
121DNA double-strand break processing (GO:0000729)2.93365893
122dicarboxylic acid biosynthetic process (GO:0043650)2.91766819
123DNA replication checkpoint (GO:0000076)2.90979225
124UTP biosynthetic process (GO:0006228)2.89447208
125layer formation in cerebral cortex (GO:0021819)2.88475042
126mannosylation (GO:0097502)2.88309412
127DNA strand elongation involved in DNA replication (GO:0006271)2.88024412
128regulation of female receptivity (GO:0045924)2.87818334
129DNA replication-independent nucleosome organization (GO:0034724)2.86765749
130DNA replication-independent nucleosome assembly (GO:0006336)2.86765749
131hydrogen ion transmembrane transport (GO:1902600)2.85996276
132DNA catabolic process, exonucleolytic (GO:0000738)2.85662783
133rRNA metabolic process (GO:0016072)2.85278504
134ribonucleoside triphosphate biosynthetic process (GO:0009201)2.82852544
135synaptic vesicle maturation (GO:0016188)2.80594389
136DNA damage response, detection of DNA damage (GO:0042769)2.80429781
137oxidative phosphorylation (GO:0006119)2.79739194
138sulfur amino acid catabolic process (GO:0000098)2.79005859
139regulation of long-term neuronal synaptic plasticity (GO:0048169)2.78970192
140regulation of synaptic vesicle exocytosis (GO:2000300)2.78808800
141maturation of 5.8S rRNA (GO:0000460)2.78603826
142cellular potassium ion homeostasis (GO:0030007)2.78328821
143positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78305843
144DNA strand elongation (GO:0022616)2.78060751
145DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77100208
146neurotransmitter secretion (GO:0007269)2.75403653
147L-phenylalanine metabolic process (GO:0006558)2.75207990
148erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75207990
149regulation of excitatory postsynaptic membrane potential (GO:0060079)2.75011562
150positive regulation of glycogen metabolic process (GO:0070875)2.73782702
151activation of protein kinase B activity (GO:0032148)2.73428226
152regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72600764
153cerebellar granule cell differentiation (GO:0021707)2.71657573
154coenzyme catabolic process (GO:0009109)2.71117605
155exploration behavior (GO:0035640)2.70429077
156positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65614758
157histone H3-K9 demethylation (GO:0033169)2.65443272
158positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.64260844
159negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63786125
160actin filament capping (GO:0051693)2.60092805
161positive regulation of pseudopodium assembly (GO:0031274)2.57314900
162triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.55869997
163response to pheromone (GO:0019236)2.55418274
164exocrine pancreas development (GO:0031017)2.53603719
165cellular response to cadmium ion (GO:0071276)2.52754269
166positive regulation of glycolytic process (GO:0045821)2.50067015
167regulation of synapse structural plasticity (GO:0051823)2.48628372
168activation of protein kinase A activity (GO:0034199)2.48078035
169dicarboxylic acid catabolic process (GO:0043649)2.46328260
170cellular ketone body metabolic process (GO:0046950)2.45457799
171regulation of postsynaptic membrane potential (GO:0060078)2.44448472
172high-density lipoprotein particle remodeling (GO:0034375)2.44071368
173regulation of plasminogen activation (GO:0010755)2.43135481
174female mating behavior (GO:0060180)2.40757182
175regulation of cAMP-dependent protein kinase activity (GO:2000479)2.38619771
176urea cycle (GO:0000050)2.38284750
177urea metabolic process (GO:0019627)2.38284750
178glutamate metabolic process (GO:0006536)2.36012173
179peptidyl-glutamic acid carboxylation (GO:0017187)2.35268093
180protein carboxylation (GO:0018214)2.35268093
181dermatan sulfate biosynthetic process (GO:0030208)2.34926091
182response to histamine (GO:0034776)2.33953232
183neuronal action potential propagation (GO:0019227)2.33826590
184regulation of synaptic vesicle transport (GO:1902803)2.33337988
185regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.33333422
186regulation of neuronal synaptic plasticity (GO:0048168)2.32968653
187bile acid biosynthetic process (GO:0006699)2.32759528
188regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.31911827
189regulation of glutamate receptor signaling pathway (GO:1900449)2.31707156
190regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.31328645
191aromatic amino acid family catabolic process (GO:0009074)2.28466456
192regulation of dendritic spine morphogenesis (GO:0061001)2.26652000
193regulation of vesicle fusion (GO:0031338)2.25513367
194heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.24766369
195regulation of cholesterol homeostasis (GO:2000188)2.24203273
196sulfur compound catabolic process (GO:0044273)2.23991255
197drug transmembrane transport (GO:0006855)2.23986284
198reverse cholesterol transport (GO:0043691)2.23769083
199vocalization behavior (GO:0071625)2.23202436
200regulation of synaptic transmission, glutamatergic (GO:0051966)2.23138126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.25654770
2GATA1_22025678_ChIP-Seq_K562_Human5.12528240
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.69764618
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.34272797
5E2F7_22180533_ChIP-Seq_HELA_Human4.12785551
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.48110406
7* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.41518744
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.34978458
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.26605090
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21542436
11AR_21572438_ChIP-Seq_LNCaP_Human3.14331233
12* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09783411
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02956010
14ELK1_19687146_ChIP-ChIP_HELA_Human2.97711287
15GBX2_23144817_ChIP-Seq_PC3_Human2.90153834
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.87165031
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.86234069
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84628484
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.73770871
20* VDR_23849224_ChIP-Seq_CD4+_Human2.64711635
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59623765
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58026559
23DROSHA_22980978_ChIP-Seq_HELA_Human2.49017093
24FOXP3_21729870_ChIP-Seq_TREG_Human2.43144154
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40337186
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36815612
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.34636716
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33464313
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.25690970
30* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23602917
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19526232
32SMAD_19615063_ChIP-ChIP_OVARY_Human2.18553145
33DCP1A_22483619_ChIP-Seq_HELA_Human2.17564187
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.11364692
35MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10707778
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09058455
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08965930
38* TTF2_22483619_ChIP-Seq_HELA_Human2.06501073
39THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04592404
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02324047
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01934429
42MYC_18940864_ChIP-ChIP_HL60_Human2.00819756
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99384735
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99307089
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99243363
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.98152025
47GABP_19822575_ChIP-Seq_HepG2_Human1.96541512
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93396096
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.91841536
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90487404
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88634621
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86520976
53TAF15_26573619_Chip-Seq_HEK293_Human1.86432203
54* XRN2_22483619_ChIP-Seq_HELA_Human1.85247203
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.85030591
56EWS_26573619_Chip-Seq_HEK293_Human1.84623497
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83973373
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83751626
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79449103
60* E2F1_21310950_ChIP-Seq_MCF-7_Human1.74626214
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74406232
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74406232
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73106354
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72210374
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65115835
66FUS_26573619_Chip-Seq_HEK293_Human1.61356259
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60003026
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57935951
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56092223
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.56048581
71EZH2_22144423_ChIP-Seq_EOC_Human1.54628789
72VDR_22108803_ChIP-Seq_LS180_Human1.53918072
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53097257
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51277499
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51095324
76* REST_21632747_ChIP-Seq_MESCs_Mouse1.50514438
77SMAD4_21799915_ChIP-Seq_A2780_Human1.49928040
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47468373
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.47222163
80PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44863418
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.44714754
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44186012
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38898006
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.38809324
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.38201500
86AR_25329375_ChIP-Seq_VCAP_Human1.37404983
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.36503640
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.34474639
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.33956769
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33631198
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32530875
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32013407
93* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31549532
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31107439
95* REST_18959480_ChIP-ChIP_MESCs_Mouse1.30629336
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28076262
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28047817
98BCAT_22108803_ChIP-Seq_LS180_Human1.25954423
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23996466
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21188635
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.20764090
102KDM5A_27292631_Chip-Seq_BREAST_Human1.18971661
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18701143
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17991211
105RXR_22108803_ChIP-Seq_LS180_Human1.16173014
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.15489809
107CBP_20019798_ChIP-Seq_JUKART_Human1.15104819
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15104819
109TP53_18474530_ChIP-ChIP_U2OS_Human1.13359515
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13090519
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12537920
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12249473
113AHR_22903824_ChIP-Seq_MCF-7_Human1.12017684
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11716677
115* P300_19829295_ChIP-Seq_ESCs_Human1.10310826
116ELK1_22589737_ChIP-Seq_MCF10A_Human1.10267566
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10190754
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10057201
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09650704
120ER_23166858_ChIP-Seq_MCF-7_Human1.09268443
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08930713
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08496403
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.07132181
124NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06355774
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06355774
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05376470
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05113257
128* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04133869
129ERG_21242973_ChIP-ChIP_JURKAT_Human1.03962379
130* FLI1_21867929_ChIP-Seq_TH2_Mouse1.03143808
131CLOCK_20551151_ChIP-Seq_293T_Human1.03117721
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02788511
133* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02462624
134EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01846207
135TP53_22573176_ChIP-Seq_HFKS_Human1.01643327
136WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01511044
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01200886
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00908099
139FOXA2_19822575_ChIP-Seq_HepG2_Human1.00700542
140DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00275899
141TP63_19390658_ChIP-ChIP_HaCaT_Human1.00209055
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99937293
143KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99093421
144RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98688329
145IGF1R_20145208_ChIP-Seq_DFB_Human0.98028371
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97830105
147MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97629030
148AR_21909140_ChIP-Seq_LNCAP_Human0.96902132
149ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96306343
150FLI1_27457419_Chip-Seq_LIVER_Mouse0.95641710
151* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95623750
152RING1B_27294783_Chip-Seq_ESCs_Mouse0.95313460
153IRF1_19129219_ChIP-ChIP_H3396_Human0.95088518
154CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93910939
155* PRDM14_20953172_ChIP-Seq_ESCs_Human0.93737946
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93544112
157* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92508570
158EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92358941
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.92029744
160TCF4_23295773_ChIP-Seq_U87_Human0.91080826
161* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90831964
162STAT3_23295773_ChIP-Seq_U87_Human0.90624930
163CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90030458
164SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89734473
165TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89467047
166TET1_21490601_ChIP-Seq_MESCs_Mouse0.89309875
167AR_19668381_ChIP-Seq_PC3_Human0.89081212
168* KDM2B_26808549_Chip-Seq_K562_Human0.88687431
169SALL1_21062744_ChIP-ChIP_HESCs_Human0.88525717
170EZH2_27304074_Chip-Seq_ESCs_Mouse0.88042321
171CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87988830
172ESR2_21235772_ChIP-Seq_MCF-7_Human0.87980547
173ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87060454
174CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87055447
175NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86329983
176SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85673647
177SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.84067874
178SOX2_16153702_ChIP-ChIP_HESCs_Human0.83601457
179RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83579677
180NANOG_16153702_ChIP-ChIP_HESCs_Human0.82931186
181ZNF274_21170338_ChIP-Seq_K562_Hela0.82763320
182FOXA1_25329375_ChIP-Seq_VCAP_Human0.81496910
183FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81496910
184POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79658590
185GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78173519
186FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78153591
187GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77663639
188CIITA_25753668_ChIP-Seq_RAJI_Human0.76495577
189NANOG_18555785_ChIP-Seq_MESCs_Mouse0.76075463
190SOX2_18555785_ChIP-Seq_MESCs_Mouse0.75016910
191TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73536743
192AR_20517297_ChIP-Seq_VCAP_Human0.72087440
193PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70701807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.70800335
2MP0005360_urolithiasis4.38708397
3MP0004859_abnormal_synaptic_plasticity4.37741620
4MP0008058_abnormal_DNA_repair4.04375017
5MP0009780_abnormal_chondrocyte_physiolo4.02285493
6MP0010094_abnormal_chromosome_stability3.45980363
7MP0005365_abnormal_bile_salt3.28217879
8MP0005503_abnormal_tendon_morphology3.13300774
9MP0006292_abnormal_olfactory_placode3.02083481
10MP0003693_abnormal_embryo_hatching2.96594474
11MP0003705_abnormal_hypodermis_morpholog2.87977497
12MP0008877_abnormal_DNA_methylation2.80240496
13MP0008057_abnormal_DNA_replication2.69800110
14MP0003635_abnormal_synaptic_transmissio2.64776211
15MP0004147_increased_porphyrin_level2.64081155
16MP0005171_absent_coat_pigmentation2.57440301
17MP0009046_muscle_twitch2.44773787
18MP0003111_abnormal_nucleus_morphology2.37799528
19MP0002938_white_spotting2.30366320
20MP0002139_abnormal_hepatobiliary_system2.25527712
21MP0003075_altered_response_to2.20096636
22MP0003011_delayed_dark_adaptation2.19390194
23MP0004858_abnormal_nervous_system2.16071422
24MP0008438_abnormal_cutaneous_collagen2.14459234
25MP0000372_irregular_coat_pigmentation2.14274795
26MP0010352_gastrointestinal_tract_polyps2.14057288
27MP0004957_abnormal_blastocyst_morpholog2.13957758
28MP0003077_abnormal_cell_cycle2.13120639
29MP0002837_dystrophic_cardiac_calcinosis2.12733454
30MP0003718_maternal_effect2.12693498
31MP0003123_paternal_imprinting2.11842283
32MP0003950_abnormal_plasma_membrane2.11660328
33MP0002063_abnormal_learning/memory/cond2.07953920
34MP0003329_amyloid_beta_deposits2.07108610
35MP0009745_abnormal_behavioral_response2.05872090
36MP0003121_genomic_imprinting2.01025208
37MP0003303_peritoneal_inflammation1.97808229
38MP0001529_abnormal_vocalization1.97648135
39MP0009379_abnormal_foot_pigmentation1.96763171
40MP0000604_amyloidosis1.96226734
41MP0002064_seizures1.96006854
42MP0006072_abnormal_retinal_apoptosis1.94157547
43MP0003786_premature_aging1.93539773
44MP0002160_abnormal_reproductive_system1.92343940
45MP0006036_abnormal_mitochondrial_physio1.89503026
46MP0003186_abnormal_redox_activity1.88499477
47MP0003880_abnormal_central_pattern1.83411578
48MP0003191_abnormal_cellular_cholesterol1.80777555
49MP0008875_abnormal_xenobiotic_pharmacok1.77807601
50MP0005275_abnormal_skin_tensile1.77399784
51MP0004130_abnormal_muscle_cell1.71119406
52MP0002876_abnormal_thyroid_physiology1.67688949
53MP0005075_abnormal_melanosome_morpholog1.66694263
54MP0005085_abnormal_gallbladder_physiolo1.64731718
55MP0005084_abnormal_gallbladder_morpholo1.64147125
56MP0001764_abnormal_homeostasis1.60386912
57MP0003136_yellow_coat_color1.59329486
58MP0002572_abnormal_emotion/affect_behav1.57845373
59MP0004270_analgesia1.57434146
60MP0001440_abnormal_grooming_behavior1.54924580
61MP0008932_abnormal_embryonic_tissue1.54485929
62MP0008995_early_reproductive_senescence1.53192577
63MP0002210_abnormal_sex_determination1.52510540
64MP0002272_abnormal_nervous_system1.47465576
65MP0006276_abnormal_autonomic_nervous1.44560717
66MP0002102_abnormal_ear_morphology1.43169112
67MP0005623_abnormal_meninges_morphology1.43122962
68MP0005253_abnormal_eye_physiology1.42615006
69MP0000920_abnormal_myelination1.42104968
70MP0005646_abnormal_pituitary_gland1.40483964
71MP0005551_abnormal_eye_electrophysiolog1.40118231
72MP0001293_anophthalmia1.39886592
73MP0008569_lethality_at_weaning1.39822625
74MP0003787_abnormal_imprinting1.39100909
75MP0004142_abnormal_muscle_tone1.37522421
76MP0002638_abnormal_pupillary_reflex1.37136784
77MP0001348_abnormal_lacrimal_gland1.36967822
78MP0001145_abnormal_male_reproductive1.35243204
79MP0005248_abnormal_Harderian_gland1.35112037
80MP0009697_abnormal_copulation1.33656348
81MP0001929_abnormal_gametogenesis1.33581878
82MP0008007_abnormal_cellular_replicative1.33374449
83MP0005389_reproductive_system_phenotype1.32959984
84MP0003656_abnormal_erythrocyte_physiolo1.32267687
85MP0001501_abnormal_sleep_pattern1.28029181
86MP0003195_calcinosis1.27210482
87MP0000358_abnormal_cell_content/1.26545081
88MP0001485_abnormal_pinna_reflex1.23107192
89MP0005410_abnormal_fertilization1.23073814
90MP0000653_abnormal_sex_gland1.22908336
91MP0003183_abnormal_peptide_metabolism1.22278577
92MP0003252_abnormal_bile_duct1.22176920
93MP0001958_emphysema1.21706913
94MP0000685_abnormal_immune_system1.21635487
95MP0003633_abnormal_nervous_system1.20851702
96MP0003690_abnormal_glial_cell1.19818632
97MP0002736_abnormal_nociception_after1.19602156
98MP0000631_abnormal_neuroendocrine_gland1.19129959
99MP0002653_abnormal_ependyma_morphology1.19099638
100MP0005174_abnormal_tail_pigmentation1.19000999
101MP0001984_abnormal_olfaction1.16598238
102MP0003868_abnormal_feces_composition1.13650752
103MP0008789_abnormal_olfactory_epithelium1.12114650
104MP0002118_abnormal_lipid_homeostasis1.11706264
105MP0002733_abnormal_thermal_nociception1.11543387
106MP0002735_abnormal_chemical_nociception1.10159951
107MP0003698_abnormal_male_reproductive1.09827512
108MP0010329_abnormal_lipoprotein_level1.09167538
109MP0005584_abnormal_enzyme/coenzyme_acti1.06868115
110MP0008874_decreased_physiological_sensi1.06613221
111MP0001486_abnormal_startle_reflex1.02910261
112MP0003122_maternal_imprinting1.02755661
113MP0002295_abnormal_pulmonary_circulatio1.02363126
114MP0003806_abnormal_nucleotide_metabolis0.99183756
115MP0008872_abnormal_physiological_respon0.98938522
116MP0004133_heterotaxia0.98459258
117MP0001873_stomach_inflammation0.97738511
118MP0004272_abnormal_basement_membrane0.97342136
119MP0002095_abnormal_skin_pigmentation0.95257102
120MP0002067_abnormal_sensory_capabilities0.94472202
121MP0003315_abnormal_perineum_morphology0.93834857
122MP0005332_abnormal_amino_acid0.93620111
123MP0002751_abnormal_autonomic_nervous0.93210067
124MP0003631_nervous_system_phenotype0.93162565
125MP0001188_hyperpigmentation0.92888890
126MP0003941_abnormal_skin_development0.92392537
127MP0000049_abnormal_middle_ear0.91416590
128MP0009764_decreased_sensitivity_to0.91326324
129MP0001286_abnormal_eye_development0.90036185
130MP0005595_abnormal_vascular_smooth0.88865936
131MP0001970_abnormal_pain_threshold0.87852651
132MP0003300_gastrointestinal_ulcer0.86938379
133MP0001346_abnormal_lacrimal_gland0.86212402
134MP0001968_abnormal_touch/_nociception0.85173040
135MP0003890_abnormal_embryonic-extraembry0.84990691
136MP0001119_abnormal_female_reproductive0.84937606
137MP0001324_abnormal_eye_pigmentation0.84829821
138MP0003634_abnormal_glial_cell0.84708561
139MP0002138_abnormal_hepatobiliary_system0.84424542
140MP0003567_abnormal_fetal_cardiomyocyte0.84314233
141MP0003279_aneurysm0.82737311
142MP0002163_abnormal_gland_morphology0.81532611
143MP0002909_abnormal_adrenal_gland0.81390027
144MP0005391_vision/eye_phenotype0.80546811
145MP0002234_abnormal_pharynx_morphology0.80201577
146MP0005266_abnormal_metabolism0.79965205
147MP0004811_abnormal_neuron_physiology0.79465985
148MP0001905_abnormal_dopamine_level0.79433753
149MP0005408_hypopigmentation0.79257940
150MP0005645_abnormal_hypothalamus_physiol0.78824536
151MP0002090_abnormal_vision0.78449272
152MP0005367_renal/urinary_system_phenotyp0.78340031
153MP0000516_abnormal_urinary_system0.78340031
154MP0000639_abnormal_adrenal_gland0.77989893
155MP0006035_abnormal_mitochondrial_morpho0.77216368
156MP0010386_abnormal_urinary_bladder0.77012166
157MP0001697_abnormal_embryo_size0.76521639
158MP0002069_abnormal_eating/drinking_beha0.76222986
159MP0001919_abnormal_reproductive_system0.75982421
160MP0002277_abnormal_respiratory_mucosa0.75871848
161MP0002734_abnormal_mechanical_nocicepti0.75605274
162MP0002233_abnormal_nose_morphology0.75152008
163MP0009840_abnormal_foam_cell0.74634235
164MP0010030_abnormal_orbit_morphology0.74099696
165MP0005187_abnormal_penis_morphology0.71787921
166MP0005195_abnormal_posterior_eye0.71613920
167MP0003936_abnormal_reproductive_system0.71607487
168MP0002108_abnormal_muscle_morphology0.71240171
169MP0002066_abnormal_motor_capabilities/c0.70838574
170MP0002332_abnormal_exercise_endurance0.69298566
171MP0004134_abnormal_chest_morphology0.69000127
172MP0002557_abnormal_social/conspecific_i0.67069876
173MP0002928_abnormal_bile_duct0.66440046
174MP0000778_abnormal_nervous_system0.65498492
175MP0003091_abnormal_cell_migration0.65317595
176MP0003632_abnormal_nervous_system0.65267059
177MP0003172_abnormal_lysosome_physiology0.64815295
178MP0002822_catalepsy0.64678823
179MP0010368_abnormal_lymphatic_system0.64531410
180MP0006054_spinal_hemorrhage0.64018573
181MP0003755_abnormal_palate_morphology0.63929601
182MP0005166_decreased_susceptibility_to0.63522909
183MP0004885_abnormal_endolymph0.63357892
184MP0000013_abnormal_adipose_tissue0.62392313
185MP0005535_abnormal_body_temperature0.62191488
186MP0000350_abnormal_cell_proliferation0.60675063
187MP0002752_abnormal_somatic_nervous0.59472852

Predicted human phenotypes

RankGene SetZ-score
1Retinal dysplasia (HP:0007973)6.21082975
2Acute necrotizing encephalopathy (HP:0006965)5.64046585
3Abnormal mitochondria in muscle tissue (HP:0008316)4.98644319
4Mitochondrial inheritance (HP:0001427)4.92035865
5Scanning speech (HP:0002168)4.77427859
6Acute encephalopathy (HP:0006846)4.75233168
7Progressive macrocephaly (HP:0004481)4.69678911
8Increased hepatocellular lipid droplets (HP:0006565)4.64517425
9Increased CSF lactate (HP:0002490)4.55616421
10Retinal atrophy (HP:0001105)4.50514402
11Lipid accumulation in hepatocytes (HP:0006561)4.49783568
12Renal Fanconi syndrome (HP:0001994)4.06992771
13Hepatocellular necrosis (HP:0001404)3.94508471
14Neonatal short-limb short stature (HP:0008921)3.91888752
15Cerebral edema (HP:0002181)3.67351721
16Buphthalmos (HP:0000557)3.65736019
17Epidermoid cyst (HP:0200040)3.63974691
18Hepatic necrosis (HP:0002605)3.59600269
19Growth hormone excess (HP:0000845)3.52558623
20Spinal rigidity (HP:0003306)3.51840956
21Reticulocytopenia (HP:0001896)3.39074628
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.33900705
23Large hands (HP:0001176)3.31604298
24Enlarged penis (HP:0000040)3.26086651
253-Methylglutaconic aciduria (HP:0003535)3.24192592
26Ileus (HP:0002595)3.21389362
27Type II lissencephaly (HP:0007260)3.19082736
28Cerebellar dysplasia (HP:0007033)3.17443317
29Subacute progressive viral hepatitis (HP:0006572)3.06155586
30Hypoglycemic seizures (HP:0002173)3.04374595
31Focal motor seizures (HP:0011153)3.02641860
32Ketoacidosis (HP:0001993)3.01921754
33Macrocytic anemia (HP:0001972)3.00004445
34Hepatocellular carcinoma (HP:0001402)2.99905670
35Congenital, generalized hypertrichosis (HP:0004540)2.94677845
36Increased intramyocellular lipid droplets (HP:0012240)2.93851034
37Abnormal number of erythroid precursors (HP:0012131)2.90982272
38Exertional dyspnea (HP:0002875)2.88331159
39Pancreatic islet-cell hyperplasia (HP:0004510)2.88258765
40Type I transferrin isoform profile (HP:0003642)2.87571370
41Abnormality of cells of the erythroid lineage (HP:0012130)2.84597078
42Pancreatic cysts (HP:0001737)2.84533636
43Amyloidosis (HP:0011034)2.84016393
44True hermaphroditism (HP:0010459)2.82261645
45Reduced subcutaneous adipose tissue (HP:0003758)2.81062933
46Thick nail (HP:0001805)2.79164110
47Increased serum lactate (HP:0002151)2.76523679
48Molar tooth sign on MRI (HP:0002419)2.74526891
49Abnormality of midbrain morphology (HP:0002418)2.74526891
50Optic disc pallor (HP:0000543)2.73838364
51Ankle clonus (HP:0011448)2.72239291
52Hypoglycemic coma (HP:0001325)2.70758316
53Deep venous thrombosis (HP:0002625)2.69627794
54Lactic acidosis (HP:0003128)2.69539933
55Chronic hepatic failure (HP:0100626)2.68759429
56Elfin facies (HP:0004428)2.67446193
57Respiratory failure (HP:0002878)2.65620743
58Abnormality of the labia minora (HP:0012880)2.65282882
59Intellectual disability, moderate (HP:0002342)2.63919035
60Mild short stature (HP:0003502)2.63082279
61Hepatoblastoma (HP:0002884)2.63012766
62Meckel diverticulum (HP:0002245)2.61297466
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60834071
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60834071
65Slender build (HP:0001533)2.60571574
66Abnormality of renal resorption (HP:0011038)2.60472334
67Hyperinsulinemic hypoglycemia (HP:0000825)2.58769568
68Exercise intolerance (HP:0003546)2.58429276
69Ketosis (HP:0001946)2.58415274
70Long foot (HP:0001833)2.58126954
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.57577249
72Pancreatic fibrosis (HP:0100732)2.57306057
73Genetic anticipation (HP:0003743)2.56538724
74Advanced eruption of teeth (HP:0006288)2.55900028
75Respiratory difficulties (HP:0002880)2.53185626
76Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53147927
77Increased muscle lipid content (HP:0009058)2.52837632
78Dysmetric saccades (HP:0000641)2.51913692
79Neurofibrillary tangles (HP:0002185)2.50441289
80Abnormality of chromosome stability (HP:0003220)2.49564993
81Myokymia (HP:0002411)2.49511390
82Abnormality of the ileum (HP:0001549)2.48992518
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.46052199
84Abnormality of saccadic eye movements (HP:0000570)2.45187641
85Progressive cerebellar ataxia (HP:0002073)2.44806933
86Conical tooth (HP:0000698)2.44522184
87Impaired smooth pursuit (HP:0007772)2.41826871
88Chromsome breakage (HP:0040012)2.40439907
89Leukodystrophy (HP:0002415)2.40200234
90Dynein arm defect of respiratory motile cilia (HP:0012255)2.39653032
91Absent/shortened dynein arms (HP:0200106)2.39653032
92Occipital encephalocele (HP:0002085)2.38878651
93Abnormal protein glycosylation (HP:0012346)2.35706341
94Abnormal glycosylation (HP:0012345)2.35706341
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35706341
96Abnormal protein N-linked glycosylation (HP:0012347)2.35706341
97Inability to walk (HP:0002540)2.35582728
98Methylmalonic acidemia (HP:0002912)2.34819055
99Cerebral inclusion bodies (HP:0100314)2.34277790
100Neoplasm of the adrenal cortex (HP:0100641)2.31076004
101Clonus (HP:0002169)2.30986208
102Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.28998084
103Abnormality of the preputium (HP:0100587)2.28462605
104Urinary bladder sphincter dysfunction (HP:0002839)2.27332436
105Lethargy (HP:0001254)2.25798710
106Abnormality of the lower motor neuron (HP:0002366)2.24156500
107Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22615716
108Intrahepatic cholestasis (HP:0001406)2.20236581
109Methylmalonic aciduria (HP:0012120)2.19302264
110Abnormality of ocular smooth pursuit (HP:0000617)2.17834654
111Visual hallucinations (HP:0002367)2.15085619
112Focal seizures (HP:0007359)2.14624843
113Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14024874
114Urinary urgency (HP:0000012)2.11197951
115Insidious onset (HP:0003587)2.09346503
116Termporal pattern (HP:0011008)2.09346503
117Abnormal lung lobation (HP:0002101)2.09086902
118Action tremor (HP:0002345)2.08682957
119Torticollis (HP:0000473)2.08604128
120Absent speech (HP:0001344)2.08583842
121Intention tremor (HP:0002080)2.08510547
122Tetraplegia (HP:0002445)2.07905367
123Slow saccadic eye movements (HP:0000514)2.07320411
124Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06978665
125Hypoplasia of the brainstem (HP:0002365)2.06978665
126Postural instability (HP:0002172)2.06236786
127Sclerocornea (HP:0000647)2.05398809
128Anterior segment dysgenesis (HP:0007700)2.04921197
129Aplasia/Hypoplasia of the tongue (HP:0010295)2.03295128
130Impaired vibration sensation in the lower limbs (HP:0002166)2.01060187
131Glycosuria (HP:0003076)2.00382189
132Abnormality of urine glucose concentration (HP:0011016)2.00382189
133Acanthosis nigricans (HP:0000956)1.98753306
134Medial flaring of the eyebrow (HP:0010747)1.97840973
135Xanthomatosis (HP:0000991)1.97193533
136Nephronophthisis (HP:0000090)1.96907602
137Sloping forehead (HP:0000340)1.96636563
138Symptomatic seizures (HP:0011145)1.93410517
139Absent thumb (HP:0009777)1.91813580
140Dysdiadochokinesis (HP:0002075)1.91678589
141Spastic tetraparesis (HP:0001285)1.90928680
142Abnormality of methionine metabolism (HP:0010901)1.90146178
143Lower limb muscle weakness (HP:0007340)1.88501082
144Hypoplasia of the pons (HP:0012110)1.88448505
145Median cleft lip (HP:0000161)1.88300479
146Triphalangeal thumb (HP:0001199)1.87731480
147Colon cancer (HP:0003003)1.87218894
148J-shaped sella turcica (HP:0002680)1.87216932
149Aplastic anemia (HP:0001915)1.87194233
150Atonic seizures (HP:0010819)1.87060950
151Tubular atrophy (HP:0000092)1.86999349
152Abnormality of the pons (HP:0007361)1.86009223
153Dysmetria (HP:0001310)1.85956755
154Spastic gait (HP:0002064)1.85800034
155Duodenal stenosis (HP:0100867)1.84223907
156Small intestinal stenosis (HP:0012848)1.84223907
157Supranuclear gaze palsy (HP:0000605)1.84219168
158Pallor (HP:0000980)1.83057369
159Hyperphosphaturia (HP:0003109)1.82885566
160Increased serum pyruvate (HP:0003542)1.82766242
161Male pseudohermaphroditism (HP:0000037)1.81675425
162Anencephaly (HP:0002323)1.81373754
163Abnormality of the pancreatic islet cells (HP:0006476)1.80989655
164Abnormality of endocrine pancreas physiology (HP:0012093)1.80989655
165Hyperlipoproteinemia (HP:0010980)1.80967987
166Complete atrioventricular canal defect (HP:0001674)1.79092545
167Increased cerebral lipofuscin (HP:0011813)1.78159471
168CNS demyelination (HP:0007305)1.77907560
169Bulbar palsy (HP:0001283)1.77662820
170Xerostomia (HP:0000217)1.77521892
171Pachygyria (HP:0001302)1.77363186
172Congenital glaucoma (HP:0001087)1.76404709
173Abnormal rod and cone electroretinograms (HP:0008323)1.76334720
174Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76310941
175Depression (HP:0000716)1.76202678
176Stomach cancer (HP:0012126)1.75943425
177Reduced antithrombin III activity (HP:0001976)1.75692236
178Type 1 muscle fiber predominance (HP:0003803)1.75581357
179X-linked dominant inheritance (HP:0001423)1.74850765
180Epileptic encephalopathy (HP:0200134)1.73390050
181Insomnia (HP:0100785)1.73287287
182Sensory axonal neuropathy (HP:0003390)1.72716147
183Microvesicular hepatic steatosis (HP:0001414)1.72432456
184Abnormality of the duodenum (HP:0002246)1.71071719
185Hyperglycinemia (HP:0002154)1.70687248
186Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69674868
187Postaxial foot polydactyly (HP:0001830)1.68447257
188Generalized aminoaciduria (HP:0002909)1.67657339
189Large for gestational age (HP:0001520)1.66821580
190Pancytopenia (HP:0001876)1.65958190
191Nephrogenic diabetes insipidus (HP:0009806)1.65111642
192Volvulus (HP:0002580)1.64698908
193Congenital primary aphakia (HP:0007707)1.63967858
194Blindness (HP:0000618)1.62420256
195Oral leukoplakia (HP:0002745)1.59965763
196Pendular nystagmus (HP:0012043)1.58619781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.70743454
2VRK23.98384009
3TRIM283.87243844
4BUB13.20957787
5CDC73.09724431
6MAP4K22.66929392
7STK162.47668400
8VRK12.33625175
9NTRK12.26946943
10TRPM72.22200760
11SRPK12.15765603
12NME22.11079851
13PINK12.10622179
14PBK2.08827536
15ZAK2.04173601
16MINK12.03706446
17MAP3K132.02790843
18MAP3K41.97678277
19MAP2K71.96767925
20PDK41.92071121
21PDK31.92071121
22BMPR1B1.89868034
23NTRK31.89116475
24NME11.87525342
25EIF2AK31.82555485
26MARK11.81005036
27TAF11.77330193
28MAP2K41.75159100
29EPHA41.74624542
30NUAK11.74474357
31PLK41.73734159
32KSR21.68716058
33TSSK61.64240777
34PDGFRA1.63657529
35TNIK1.63278286
36CCNB11.60015834
37PLK31.59381486
38WNK31.58093930
39WEE11.56873709
40FER1.51033014
41EIF2AK11.49529148
42CSNK1G21.49238350
43FRK1.48846693
44CSNK1A1L1.48145401
45ARAF1.47666167
46SCYL21.47378951
47CDK81.46568121
48PAK61.45376152
49EPHB11.44642281
50CAMKK11.44432145
51DYRK21.43099818
52MST41.40772524
53CDK191.40494412
54PLK11.38386123
55PLK21.36154235
56FES1.34576355
57TTK1.34293009
58PNCK1.32543695
59BRSK21.31923582
60MAP3K91.31163059
61FGFR41.28041844
62FLT31.26275231
63MKNK11.24392317
64NEK11.24050342
65NTRK21.21119568
66EPHA31.18104765
67DAPK21.17278264
68GRK11.16676876
69ATR1.16323618
70CSNK1G31.15412870
71CAMKK21.15227434
72ADRBK21.12119384
73MKNK21.11935805
74JAK11.11195571
75RET1.11185100
76TRIB31.09662930
77MAP3K121.08836401
78PRPF4B1.05506067
79AURKB1.01881544
80DAPK10.99350430
81NEK20.98247567
82KSR10.97006604
83ERN10.93948819
84ERBB30.93536503
85FGFR20.91718665
86CAMK1G0.90659169
87PHKG10.89495043
88PHKG20.89495043
89CDK50.88324306
90SIK20.85372849
91DYRK30.83944448
92TLK10.83558260
93PRKD30.83294692
94MAP3K140.83064816
95CHEK20.82467120
96CSNK1G10.78743344
97MAP3K70.77732546
98SGK2230.77294767
99SGK4940.77294767
100PAK30.77280696
101DDR20.76893502
102CDK70.76171420
103SGK20.75520073
104MAP3K20.75463835
105PIM20.75457982
106ABL20.74777442
107PDK20.74600799
108PRKCG0.73556652
109TYK20.73490485
110RAF10.73174869
111FGFR30.72568443
112RPS6KA50.71421408
113CSNK2A10.70498732
114LMTK20.69843980
115CLK10.69793978
116MAP3K50.69269957
117BRSK10.68773469
118EIF2AK20.68715716
119JAK30.68340723
120PTK2B0.67977530
121MET0.67459856
122CSNK2A20.67040553
123MAPKAPK30.67004367
124ILK0.66324085
125ACVR1B0.64610375
126PTK20.62022265
127PRKCI0.61500679
128MARK30.60514596
129SGK30.59258635
130ATM0.59206492
131JAK20.57508489
132CHEK10.55973440
133CASK0.55708048
134CAMK2G0.54334371
135CSK0.53866285
136BCR0.53729719
137PASK0.53612455
138BCKDK0.51607719
139PRKCZ0.51142152
140NEK90.51068024
141CSNK1E0.50259677
142PRKCQ0.49419435
143TGFBR10.48886292
144RPS6KA40.47221848
145MAP2K10.46277896
146SIK10.46167856
147PTK60.46130774
148CDK30.45224339
149WNK40.44456434
150RPS6KB20.43759518
151AURKA0.42932302
152PRKCE0.42703449
153STK40.41963872
154MAPK130.39515576
155MAP3K10.39310441
156MAPKAPK50.39015263
157TESK10.38934273
158PRKCH0.38700672
159TYRO30.38173177
160FYN0.38089321
161ADRBK10.36127392
162SRC0.36042421
163TIE10.34522185
164DAPK30.32859679
165CDK10.32541336
166INSR0.31633822
167RIPK10.31625853
168ROCK20.31455717
169CSNK1A10.31312236
170SGK10.31183748
171PDK10.30594858
172MAPK150.30382043
173OXSR10.28106247
174CDK20.23382276

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.15091346
2Ribosome_Homo sapiens_hsa030104.11501520
3Nitrogen metabolism_Homo sapiens_hsa009103.95750884
4Parkinsons disease_Homo sapiens_hsa050123.56533415
5Proteasome_Homo sapiens_hsa030503.55676577
6Protein export_Homo sapiens_hsa030603.25236302
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17734460
8RNA polymerase_Homo sapiens_hsa030203.06320578
9Homologous recombination_Homo sapiens_hsa034402.96795385
10DNA replication_Homo sapiens_hsa030302.89188842
11Mismatch repair_Homo sapiens_hsa034302.87729244
12Huntingtons disease_Homo sapiens_hsa050162.57566368
13Sulfur metabolism_Homo sapiens_hsa009202.57302692
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49256121
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.32032672
16Alzheimers disease_Homo sapiens_hsa050102.30335420
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.22593995
18Nucleotide excision repair_Homo sapiens_hsa034202.19373338
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.17366796
20Fanconi anemia pathway_Homo sapiens_hsa034602.16994366
21Olfactory transduction_Homo sapiens_hsa047402.08587371
22Spliceosome_Homo sapiens_hsa030402.00234173
23Basal transcription factors_Homo sapiens_hsa030221.97137584
24One carbon pool by folate_Homo sapiens_hsa006701.95382410
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.95304677
26Nicotine addiction_Homo sapiens_hsa050331.92736270
27Base excision repair_Homo sapiens_hsa034101.87823463
28Pyrimidine metabolism_Homo sapiens_hsa002401.84477462
29Arginine biosynthesis_Homo sapiens_hsa002201.84233063
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.80607036
31Fatty acid biosynthesis_Homo sapiens_hsa000611.77957862
32RNA degradation_Homo sapiens_hsa030181.77004908
33Synaptic vesicle cycle_Homo sapiens_hsa047211.74838322
34Circadian entrainment_Homo sapiens_hsa047131.66850993
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66123552
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66073801
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66020588
38GABAergic synapse_Homo sapiens_hsa047271.61069365
39Glutamatergic synapse_Homo sapiens_hsa047241.60522162
40Non-homologous end-joining_Homo sapiens_hsa034501.60368013
41Selenocompound metabolism_Homo sapiens_hsa004501.59658930
42Cardiac muscle contraction_Homo sapiens_hsa042601.59210407
43RNA transport_Homo sapiens_hsa030131.57667275
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49723165
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45711246
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44910000
47Bile secretion_Homo sapiens_hsa049761.44459849
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43749107
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39147288
50Amphetamine addiction_Homo sapiens_hsa050311.32847323
51Salivary secretion_Homo sapiens_hsa049701.30645514
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29628072
53Morphine addiction_Homo sapiens_hsa050321.29540757
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29304107
55Purine metabolism_Homo sapiens_hsa002301.28415913
56Renin secretion_Homo sapiens_hsa049241.26581945
57Folate biosynthesis_Homo sapiens_hsa007901.23412661
58Long-term potentiation_Homo sapiens_hsa047201.21253267
59Thyroid hormone synthesis_Homo sapiens_hsa049181.20976830
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14110121
61PPAR signaling pathway_Homo sapiens_hsa033201.13713086
62Dopaminergic synapse_Homo sapiens_hsa047281.13146520
63Cell cycle_Homo sapiens_hsa041101.11850669
64Fatty acid metabolism_Homo sapiens_hsa012121.11685780
65Phototransduction_Homo sapiens_hsa047441.08845079
66Fatty acid elongation_Homo sapiens_hsa000621.08782540
67Butanoate metabolism_Homo sapiens_hsa006501.02169252
68Gastric acid secretion_Homo sapiens_hsa049711.02067780
69Glutathione metabolism_Homo sapiens_hsa004801.01136087
70Fatty acid degradation_Homo sapiens_hsa000711.00858866
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.99834350
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97772039
73Type II diabetes mellitus_Homo sapiens_hsa049300.97619472
74Propanoate metabolism_Homo sapiens_hsa006400.97234712
75Sulfur relay system_Homo sapiens_hsa041220.96711868
76Long-term depression_Homo sapiens_hsa047300.94390754
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94103828
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93157789
79Tryptophan metabolism_Homo sapiens_hsa003800.92853881
80Regulation of autophagy_Homo sapiens_hsa041400.92317505
81Complement and coagulation cascades_Homo sapiens_hsa046100.86937433
82Metabolic pathways_Homo sapiens_hsa011000.86560330
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84740566
84Gap junction_Homo sapiens_hsa045400.82526453
85Oxytocin signaling pathway_Homo sapiens_hsa049210.81267384
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80615216
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.80546417
88Pyruvate metabolism_Homo sapiens_hsa006200.80059772
89Cholinergic synapse_Homo sapiens_hsa047250.80004770
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78403892
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77163889
92Cocaine addiction_Homo sapiens_hsa050300.76973930
93Peroxisome_Homo sapiens_hsa041460.72315576
94Estrogen signaling pathway_Homo sapiens_hsa049150.71224034
95cAMP signaling pathway_Homo sapiens_hsa040240.70089396
96Steroid biosynthesis_Homo sapiens_hsa001000.65995099
97Glioma_Homo sapiens_hsa052140.65688634
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63390828
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.62974766
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62123342
101Collecting duct acid secretion_Homo sapiens_hsa049660.61876330
102Taste transduction_Homo sapiens_hsa047420.61121199
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58947990
104Insulin secretion_Homo sapiens_hsa049110.58593572
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57490106
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56471286
107Calcium signaling pathway_Homo sapiens_hsa040200.56164541
108Vitamin B6 metabolism_Homo sapiens_hsa007500.55851033
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.55763764
110p53 signaling pathway_Homo sapiens_hsa041150.55577468
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.55198391
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54418512
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53850097
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53385549
115Oocyte meiosis_Homo sapiens_hsa041140.53362092
116Histidine metabolism_Homo sapiens_hsa003400.51135638
117Chemical carcinogenesis_Homo sapiens_hsa052040.49446777
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49228663
119Ovarian steroidogenesis_Homo sapiens_hsa049130.48966684
120GnRH signaling pathway_Homo sapiens_hsa049120.47965625
121mRNA surveillance pathway_Homo sapiens_hsa030150.47828253
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47464393
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47417485
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47113394
125Rap1 signaling pathway_Homo sapiens_hsa040150.46618743
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45394103
127Asthma_Homo sapiens_hsa053100.43953132
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.43384904
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42858728
130Insulin resistance_Homo sapiens_hsa049310.40708718
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40647189
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40407089
133Biosynthesis of amino acids_Homo sapiens_hsa012300.39222913
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39077821
135Prion diseases_Homo sapiens_hsa050200.38401837
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38383741
137VEGF signaling pathway_Homo sapiens_hsa043700.37076747
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37068747
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36894499
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36613885
141ABC transporters_Homo sapiens_hsa020100.36585747
142Axon guidance_Homo sapiens_hsa043600.36549695
143N-Glycan biosynthesis_Homo sapiens_hsa005100.36348313
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35969290
145African trypanosomiasis_Homo sapiens_hsa051430.35641720
146Linoleic acid metabolism_Homo sapiens_hsa005910.34790335
147Ras signaling pathway_Homo sapiens_hsa040140.34635309
148Dorso-ventral axis formation_Homo sapiens_hsa043200.34520870
149Glucagon signaling pathway_Homo sapiens_hsa049220.34453835
150Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34409534
151Endometrial cancer_Homo sapiens_hsa052130.33873730
152MAPK signaling pathway_Homo sapiens_hsa040100.32747066
153beta-Alanine metabolism_Homo sapiens_hsa004100.32711511
154Serotonergic synapse_Homo sapiens_hsa047260.31872093
155Carbon metabolism_Homo sapiens_hsa012000.31658355
156Phenylalanine metabolism_Homo sapiens_hsa003600.31230201
157Insulin signaling pathway_Homo sapiens_hsa049100.29504782
158Glycerolipid metabolism_Homo sapiens_hsa005610.29229388
159Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27825072
160Choline metabolism in cancer_Homo sapiens_hsa052310.27259033
161alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26589431
162Ether lipid metabolism_Homo sapiens_hsa005650.25855123
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25102904
164Vitamin digestion and absorption_Homo sapiens_hsa049770.22699442
165Arachidonic acid metabolism_Homo sapiens_hsa005900.21087865
166Steroid hormone biosynthesis_Homo sapiens_hsa001400.19331716
167Retinol metabolism_Homo sapiens_hsa008300.18639141
168TGF-beta signaling pathway_Homo sapiens_hsa043500.18355050
169Epstein-Barr virus infection_Homo sapiens_hsa051690.17348972
170Basal cell carcinoma_Homo sapiens_hsa052170.13178789
171Caffeine metabolism_Homo sapiens_hsa002320.11459546
172Mineral absorption_Homo sapiens_hsa049780.10731246

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