TMEM179

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.99879053
2vocalization behavior (GO:0071625)5.42965253
3synaptic vesicle exocytosis (GO:0016079)5.33207576
4synaptic vesicle maturation (GO:0016188)5.25468979
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22177351
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.17997084
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11078661
8locomotory exploration behavior (GO:0035641)5.04001131
9neuron cell-cell adhesion (GO:0007158)4.94342881
10regulation of glutamate receptor signaling pathway (GO:1900449)4.87995844
11protein localization to synapse (GO:0035418)4.78467785
12regulation of synaptic vesicle exocytosis (GO:2000300)4.77006669
13glutamate secretion (GO:0014047)4.75873112
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.63160577
15neurotransmitter secretion (GO:0007269)4.40739915
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.33757774
17neuronal action potential propagation (GO:0019227)4.30981961
18regulation of synaptic vesicle transport (GO:1902803)4.28017493
19proline transport (GO:0015824)4.27732442
20exploration behavior (GO:0035640)4.27616870
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.24261791
22cerebellar granule cell differentiation (GO:0021707)4.21145085
23regulation of neuronal synaptic plasticity (GO:0048168)4.15913784
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.13726532
25glutamate receptor signaling pathway (GO:0007215)4.10659688
26L-amino acid import (GO:0043092)4.07219716
27synaptic transmission, glutamatergic (GO:0035249)4.07143642
28neuron-neuron synaptic transmission (GO:0007270)3.99021979
29regulation of synapse structural plasticity (GO:0051823)3.91676982
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.91026952
31positive regulation of dendritic spine development (GO:0060999)3.90874969
32neuron recognition (GO:0008038)3.85888033
33layer formation in cerebral cortex (GO:0021819)3.78721870
34neurotransmitter transport (GO:0006836)3.73131889
35amino acid import (GO:0043090)3.73038302
36neurotransmitter-gated ion channel clustering (GO:0072578)3.72143678
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71958242
38gamma-aminobutyric acid transport (GO:0015812)3.70593309
39positive regulation of synaptic transmission, GABAergic (GO:0032230)3.68718845
40transmission of nerve impulse (GO:0019226)3.67646345
41regulation of voltage-gated calcium channel activity (GO:1901385)3.67021652
42regulation of synapse maturation (GO:0090128)3.64763939
43long-term memory (GO:0007616)3.63532339
44dendritic spine morphogenesis (GO:0060997)3.60736106
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60044082
46negative regulation of dendrite morphogenesis (GO:0050774)3.59890522
47regulation of postsynaptic membrane potential (GO:0060078)3.59745242
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.59315065
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.57917208
50potassium ion homeostasis (GO:0055075)3.54909903
51activation of protein kinase A activity (GO:0034199)3.53648089
52potassium ion import (GO:0010107)3.53244035
53positive regulation of dendritic spine morphogenesis (GO:0061003)3.52276408
54axon ensheathment in central nervous system (GO:0032291)3.52037082
55central nervous system myelination (GO:0022010)3.52037082
56regulation of vesicle fusion (GO:0031338)3.51597557
57positive regulation of membrane potential (GO:0045838)3.50861003
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.50636085
59chemosensory behavior (GO:0007635)3.48538966
60neuromuscular process controlling posture (GO:0050884)3.48112194
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47942894
62regulation of neurotransmitter levels (GO:0001505)3.44134143
63dendritic spine organization (GO:0097061)3.42469645
64regulation of synaptic plasticity (GO:0048167)3.40149933
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39886129
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.39813427
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38647984
68axonal fasciculation (GO:0007413)3.37659864
69regulation of glutamate secretion (GO:0014048)3.37272461
70regulation of neurotransmitter secretion (GO:0046928)3.37005041
71neuromuscular synaptic transmission (GO:0007274)3.36684488
72cellular potassium ion homeostasis (GO:0030007)3.35028936
73postsynaptic membrane organization (GO:0001941)3.31890729
74regulation of ARF protein signal transduction (GO:0032012)3.31099414
75positive regulation of synapse maturation (GO:0090129)3.30587736
76regulation of dendritic spine development (GO:0060998)3.28998989
77long-term synaptic potentiation (GO:0060291)3.28800999
78regulation of dendritic spine morphogenesis (GO:0061001)3.26394248
79positive regulation of neurotransmitter transport (GO:0051590)3.24256595
80mating behavior (GO:0007617)3.23787434
81response to histamine (GO:0034776)3.23646213
82synaptic vesicle endocytosis (GO:0048488)3.22474605
83presynaptic membrane assembly (GO:0097105)3.21402962
84behavioral defense response (GO:0002209)3.20768841
85behavioral fear response (GO:0001662)3.20768841
86cell communication by electrical coupling (GO:0010644)3.18858706
87cerebellar Purkinje cell differentiation (GO:0021702)3.18539993
88regulation of neurotransmitter transport (GO:0051588)3.17385179
89membrane depolarization (GO:0051899)3.16952948
90cerebellar Purkinje cell layer development (GO:0021680)3.15933357
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.14575077
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13565424
93prepulse inhibition (GO:0060134)3.13519944
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13098209
95fear response (GO:0042596)3.12911493
96regulation of protein kinase A signaling (GO:0010738)3.12490141
97membrane hyperpolarization (GO:0060081)3.11707366
98membrane depolarization during action potential (GO:0086010)3.11662022
99cell differentiation in hindbrain (GO:0021533)3.10058683
100positive regulation of neurotransmitter secretion (GO:0001956)3.08879014
101neuromuscular process controlling balance (GO:0050885)3.07095943
102synaptic transmission (GO:0007268)3.04899063
103detection of calcium ion (GO:0005513)3.04636850
104learning (GO:0007612)3.04325448
105negative regulation of amino acid transport (GO:0051956)3.04127275
106establishment of synaptic vesicle localization (GO:0097480)3.03492625
107synaptic vesicle transport (GO:0048489)3.03492625
108acidic amino acid transport (GO:0015800)3.02362191
109vesicle transport along microtubule (GO:0047496)3.02070794
110striatum development (GO:0021756)3.01865080
111cellular sodium ion homeostasis (GO:0006883)3.01608497
112positive regulation of synaptic transmission (GO:0050806)3.01424761
113synapse assembly (GO:0007416)3.01090234
114regulation of synaptic transmission (GO:0050804)3.00394829
115signal release (GO:0023061)3.00311549
116intraspecies interaction between organisms (GO:0051703)2.99907815
117social behavior (GO:0035176)2.99907815
118presynaptic membrane organization (GO:0097090)2.96699046
119regulation of synaptic transmission, GABAergic (GO:0032228)2.96683279
120response to auditory stimulus (GO:0010996)2.94705888
121startle response (GO:0001964)2.94044610
122auditory behavior (GO:0031223)2.93559307
123glycine transport (GO:0015816)2.92186481
124cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90630206
125cell migration in hindbrain (GO:0021535)2.89782838
126neuronal ion channel clustering (GO:0045161)2.88887025
127sodium ion export (GO:0071436)2.88693514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.37796709
2GBX2_23144817_ChIP-Seq_PC3_Human3.66318354
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.28207006
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17242962
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15796437
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.82436421
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76663914
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74908080
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74507907
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74507907
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61241948
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59732244
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58882718
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.58752134
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57380066
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.51142725
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.37721203
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.32832526
19DROSHA_22980978_ChIP-Seq_HELA_Human2.29802298
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27880511
21TAF15_26573619_Chip-Seq_HEK293_Human2.27813535
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.23962719
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22446412
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20638604
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19687140
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.13101753
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99153437
28AR_21572438_ChIP-Seq_LNCaP_Human1.97550373
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94601028
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88037349
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86994691
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86620131
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78733241
34SMAD4_21799915_ChIP-Seq_A2780_Human1.70284086
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58166340
36ZNF274_21170338_ChIP-Seq_K562_Hela1.56588720
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55518453
38* ERG_21242973_ChIP-ChIP_JURKAT_Human1.52147678
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51797275
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50241917
41P300_19829295_ChIP-Seq_ESCs_Human1.49041157
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45411255
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44100953
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41462685
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.36181301
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34453398
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.32496344
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31825533
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31748970
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31299971
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31027428
52AR_25329375_ChIP-Seq_VCAP_Human1.30153564
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.29607311
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.28759232
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.27973579
56* TET1_21490601_ChIP-Seq_MESCs_Mouse1.27812358
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27524890
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25699538
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24702650
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23537715
61IGF1R_20145208_ChIP-Seq_DFB_Human1.20533816
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.19711495
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17675433
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17438203
65RNF2_27304074_Chip-Seq_NSC_Mouse1.16992440
66STAT3_23295773_ChIP-Seq_U87_Human1.16576723
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14689624
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14357160
69AR_19668381_ChIP-Seq_PC3_Human1.11100200
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09825157
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09459850
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07555408
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06924935
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.05901972
75TCF4_23295773_ChIP-Seq_U87_Human1.05721208
76FUS_26573619_Chip-Seq_HEK293_Human1.05334386
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04489849
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.04038674
79* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03151601
80RUNX2_22187159_ChIP-Seq_PCA_Human1.02768955
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01400017
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.01310263
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00950798
84JUN_21703547_ChIP-Seq_K562_Human1.00452128
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99905380
86RING1B_27294783_Chip-Seq_NPCs_Mouse0.99156447
87VDR_22108803_ChIP-Seq_LS180_Human0.97580849
88ARNT_22903824_ChIP-Seq_MCF-7_Human0.96074366
89OCT4_19829295_ChIP-Seq_ESCs_Human0.95915329
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95781960
91YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95764161
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95098746
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95006174
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.92910942
95AHR_22903824_ChIP-Seq_MCF-7_Human0.92644563
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91829317
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90773028
98ER_23166858_ChIP-Seq_MCF-7_Human0.90256443
99BCAT_22108803_ChIP-Seq_LS180_Human0.89452970
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89327968
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88835643
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88227192
103SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88144471
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87633470
105DPY_21335234_ChIP-Seq_ESCs_Mouse0.87610418
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86371999
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86194681
108ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85706733
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85702041
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85702041
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85692315
112* SMAD4_21741376_ChIP-Seq_HESCs_Human0.84688569
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83905443
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83361496
115TP53_18474530_ChIP-ChIP_U2OS_Human0.82882534
116CTCF_27219007_Chip-Seq_Bcells_Human0.82412120
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81869913
118KDM2B_26808549_Chip-Seq_K562_Human0.81660631
119* SMC4_20622854_ChIP-Seq_HELA_Human0.80910145
120LXR_22292898_ChIP-Seq_THP-1_Human0.79982286
121* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79917479
122* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78455894
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77603679
124RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76268239
125KLF4_19829295_ChIP-Seq_ESCs_Human0.75927394
126SMAD4_21741376_ChIP-Seq_ESCs_Human0.75417405
127NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.72368152
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71428605
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71242761
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71067513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.79144186
2MP0003880_abnormal_central_pattern5.12709888
3MP0003635_abnormal_synaptic_transmissio3.99233444
4MP0002822_catalepsy3.50401267
5MP0009745_abnormal_behavioral_response3.46059027
6MP0004270_analgesia3.44877242
7MP0001968_abnormal_touch/_nociception3.32030481
8MP0002063_abnormal_learning/memory/cond3.20042739
9MP0002064_seizures3.14260191
10MP0009046_muscle_twitch2.96267703
11MP0002572_abnormal_emotion/affect_behav2.80226563
12MP0002734_abnormal_mechanical_nocicepti2.64893214
13MP0002272_abnormal_nervous_system2.61474187
14MP0002736_abnormal_nociception_after2.58936662
15MP0005423_abnormal_somatic_nervous2.57238972
16MP0001501_abnormal_sleep_pattern2.51222699
17MP0002735_abnormal_chemical_nociception2.50260540
18MP0006276_abnormal_autonomic_nervous2.49083916
19MP0001440_abnormal_grooming_behavior2.41572720
20MP0001486_abnormal_startle_reflex2.38793982
21MP0002733_abnormal_thermal_nociception2.29830135
22MP0001970_abnormal_pain_threshold2.16167227
23MP0001529_abnormal_vocalization2.03438352
24MP0002067_abnormal_sensory_capabilities1.99527714
25MP0003122_maternal_imprinting1.87258302
26MP0005386_behavior/neurological_phenoty1.84214961
27MP0004924_abnormal_behavior1.84214961
28MP0004858_abnormal_nervous_system1.79254471
29MP0003329_amyloid_beta_deposits1.78842555
30MP0002184_abnormal_innervation1.77837228
31MP0005645_abnormal_hypothalamus_physiol1.72212601
32MP0002557_abnormal_social/conspecific_i1.71057229
33MP0005646_abnormal_pituitary_gland1.70199132
34MP0009780_abnormal_chondrocyte_physiolo1.64325759
35MP0000778_abnormal_nervous_system1.63894384
36MP0002909_abnormal_adrenal_gland1.63563017
37MP0001905_abnormal_dopamine_level1.62320421
38MP0004811_abnormal_neuron_physiology1.58494532
39MP0008569_lethality_at_weaning1.58064391
40MP0001984_abnormal_olfaction1.55896055
41MP0002837_dystrophic_cardiac_calcinosis1.47678963
42MP0004142_abnormal_muscle_tone1.46754023
43MP0003787_abnormal_imprinting1.42330015
44MP0000955_abnormal_spinal_cord1.42258274
45MP0003879_abnormal_hair_cell1.39058058
46MP0002066_abnormal_motor_capabilities/c1.38052744
47MP0010386_abnormal_urinary_bladder1.36551254
48MP0002882_abnormal_neuron_morphology1.33768067
49MP0000751_myopathy1.32255797
50MP0001502_abnormal_circadian_rhythm1.27612419
51MP0008872_abnormal_physiological_respon1.20440917
52MP0008877_abnormal_DNA_methylation1.20079363
53MP0003633_abnormal_nervous_system1.19981755
54MP0001188_hyperpigmentation1.17311574
55MP0002638_abnormal_pupillary_reflex1.15364986
56MP0005535_abnormal_body_temperature1.03737397
57MP0002876_abnormal_thyroid_physiology1.03665811
58MP0004885_abnormal_endolymph1.03171109
59MP0003631_nervous_system_phenotype1.02377519
60MP0000013_abnormal_adipose_tissue1.01319670
61MP0002152_abnormal_brain_morphology0.99366793
62MP0002069_abnormal_eating/drinking_beha0.96931341
63MP0008874_decreased_physiological_sensi0.94310599
64MP0002229_neurodegeneration0.91834892
65MP0004145_abnormal_muscle_electrophysio0.91824237
66MP0005551_abnormal_eye_electrophysiolog0.86590514
67MP0001986_abnormal_taste_sensitivity0.84412138
68MP0004085_abnormal_heartbeat0.83179420
69MP0004742_abnormal_vestibular_system0.80198255
70MP0001348_abnormal_lacrimal_gland0.79362704
71MP0000604_amyloidosis0.78896656
72MP0001177_atelectasis0.76683481
73MP0002752_abnormal_somatic_nervous0.74819078
74MP0001963_abnormal_hearing_physiology0.74701829
75MP0003634_abnormal_glial_cell0.74163562
76MP0004215_abnormal_myocardial_fiber0.73226897
77MP0005394_taste/olfaction_phenotype0.72520148
78MP0005499_abnormal_olfactory_system0.72520148
79MP0001664_abnormal_digestion0.71458020
80MP0008961_abnormal_basal_metabolism0.71366990
81MP0000631_abnormal_neuroendocrine_gland0.70826993
82MP0003123_paternal_imprinting0.69579288
83MP0003632_abnormal_nervous_system0.67967046
84MP0003861_abnormal_nervous_system0.67827449
85MP0003121_genomic_imprinting0.65828770
86MP0002090_abnormal_vision0.65789709
87MP0003690_abnormal_glial_cell0.64463895
88MP0004484_altered_response_of0.63398306
89MP0003283_abnormal_digestive_organ0.61758468
90MP0003137_abnormal_impulse_conducting0.59711099
91MP0000026_abnormal_inner_ear0.58912632
92MP0005167_abnormal_blood-brain_barrier0.58768286
93MP0000920_abnormal_myelination0.58708065
94MP0005379_endocrine/exocrine_gland_phen0.58593419
95MP0003938_abnormal_ear_development0.58401254
96MP0010769_abnormal_survival0.58036855
97MP0004510_myositis0.57952290
98MP0003075_altered_response_to0.57699399
99MP0005409_darkened_coat_color0.57571471
100MP0010770_preweaning_lethality0.56929880
101MP0002082_postnatal_lethality0.56929880
102MP0001346_abnormal_lacrimal_gland0.56496455
103MP0001943_abnormal_respiration0.56036140
104MP0002653_abnormal_ependyma_morphology0.55392204
105MP0003183_abnormal_peptide_metabolism0.55347820
106MP0010768_mortality/aging0.54882464
107MP0004133_heterotaxia0.54022063
108MP0001299_abnormal_eye_distance/0.53448942
109MP0003119_abnormal_digestive_system0.53156913
110MP0000639_abnormal_adrenal_gland0.52975505
111MP0002751_abnormal_autonomic_nervous0.51821738
112MP0000747_muscle_weakness0.51267833
113MP0005623_abnormal_meninges_morphology0.51058899
114MP0005448_abnormal_energy_balance0.50754193
115MP0004130_abnormal_muscle_cell0.49629333
116MP0006072_abnormal_retinal_apoptosis0.49474015
117MP0003956_abnormal_body_size0.49227474
118MP0004233_abnormal_muscle_weight0.47503579
119MP0001485_abnormal_pinna_reflex0.47208261

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.01423216
2Myokymia (HP:0002411)7.19609636
3Focal seizures (HP:0007359)5.83341317
4Visual hallucinations (HP:0002367)5.39228580
5Atonic seizures (HP:0010819)5.02203651
6Febrile seizures (HP:0002373)4.64266904
7Epileptic encephalopathy (HP:0200134)4.57365541
8Absence seizures (HP:0002121)4.40263849
9Progressive cerebellar ataxia (HP:0002073)4.24685438
10Generalized tonic-clonic seizures (HP:0002069)4.13089708
11Dialeptic seizures (HP:0011146)4.00876102
12Supranuclear gaze palsy (HP:0000605)3.48361276
13Action tremor (HP:0002345)3.44822360
14Amblyopia (HP:0000646)3.33660078
15Broad-based gait (HP:0002136)3.30917863
16Abnormal eating behavior (HP:0100738)3.28951907
17Hyperventilation (HP:0002883)3.26414908
18Anxiety (HP:0000739)3.23518923
19Impaired vibration sensation in the lower limbs (HP:0002166)3.17951520
20Ankle clonus (HP:0011448)3.17946828
21Depression (HP:0000716)3.10826400
22Limb dystonia (HP:0002451)3.08760012
23Poor eye contact (HP:0000817)3.07095937
24Polyphagia (HP:0002591)3.02802736
25Cerebral hypomyelination (HP:0006808)3.01233166
26Truncal ataxia (HP:0002078)2.96469991
27Gaze-evoked nystagmus (HP:0000640)2.95467982
28Annular pancreas (HP:0001734)2.92648987
29Urinary bladder sphincter dysfunction (HP:0002839)2.91150645
30Dysdiadochokinesis (HP:0002075)2.90204021
31Progressive inability to walk (HP:0002505)2.89893154
32Abnormal social behavior (HP:0012433)2.84978870
33Impaired social interactions (HP:0000735)2.84978870
34Dysmetria (HP:0001310)2.84644944
35Obstructive sleep apnea (HP:0002870)2.81325513
36Mutism (HP:0002300)2.73823612
37Pheochromocytoma (HP:0002666)2.71661383
38Cerebral inclusion bodies (HP:0100314)2.66057781
39Tetraplegia (HP:0002445)2.62987096
40Papilledema (HP:0001085)2.60391157
41Failure to thrive in infancy (HP:0001531)2.60213542
42Drooling (HP:0002307)2.60105943
43Excessive salivation (HP:0003781)2.60105943
44Postural instability (HP:0002172)2.58379662
45Clonus (HP:0002169)2.54248970
46Hypoglycemic seizures (HP:0002173)2.53916948
47Neurofibrillary tangles (HP:0002185)2.52500085
48Urinary urgency (HP:0000012)2.52140265
49Insidious onset (HP:0003587)2.50735579
50Termporal pattern (HP:0011008)2.50735579
51Spastic gait (HP:0002064)2.47392429
52Bradykinesia (HP:0002067)2.46065205
53Increased circulating renin level (HP:0000848)2.45988696
54Hyperinsulinemic hypoglycemia (HP:0000825)2.45792231
55Epileptiform EEG discharges (HP:0011182)2.45126529
56Torticollis (HP:0000473)2.44258897
57Neuroendocrine neoplasm (HP:0100634)2.42943871
58Hemiparesis (HP:0001269)2.38042770
59Genetic anticipation (HP:0003743)2.36789561
60Focal dystonia (HP:0004373)2.35386357
61Agitation (HP:0000713)2.34223161
62Hypoventilation (HP:0002791)2.32763326
63EEG with generalized epileptiform discharges (HP:0011198)2.31581139
64Peripheral hypomyelination (HP:0007182)2.29663303
65Diplopia (HP:0000651)2.29353856
66Abnormality of binocular vision (HP:0011514)2.29353856
67Fetal akinesia sequence (HP:0001989)2.28285489
68Scanning speech (HP:0002168)2.25150609
69Abnormality of the lower motor neuron (HP:0002366)2.24462488
70Insomnia (HP:0100785)2.23805631
71Inability to walk (HP:0002540)2.23195895
72Impaired smooth pursuit (HP:0007772)2.22951589
73Absent speech (HP:0001344)2.22815074
74Apathy (HP:0000741)2.17942990
75Hypsarrhythmia (HP:0002521)2.17878054
76Abnormality of the corticospinal tract (HP:0002492)2.17506143
77Craniofacial dystonia (HP:0012179)2.17023982
78Status epilepticus (HP:0002133)2.16095443
79Lower limb muscle weakness (HP:0007340)2.15345113
80Psychosis (HP:0000709)2.14650001
81Spastic tetraparesis (HP:0001285)2.12273306
82Delusions (HP:0000746)2.12260993
83Hemiplegia (HP:0002301)2.10769233
84Poor suck (HP:0002033)2.06979304
85Generalized myoclonic seizures (HP:0002123)2.06403366
86Ventricular fibrillation (HP:0001663)2.01422717
87Choreoathetosis (HP:0001266)2.01013941
88Hypothermia (HP:0002045)2.00330531
89Hyperthyroidism (HP:0000836)2.00098223
90Impaired vibratory sensation (HP:0002495)1.99304031
91Gait imbalance (HP:0002141)1.99130381
92Morphological abnormality of the pyramidal tract (HP:0002062)1.98232330
93CNS hypomyelination (HP:0003429)1.98042159
94Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97602631
95Specific learning disability (HP:0001328)1.95918905
96Stereotypic behavior (HP:0000733)1.95152074
97Abnormal hair whorl (HP:0010721)1.94066195
98Muscular hypotonia of the trunk (HP:0008936)1.93790740
99Impaired pain sensation (HP:0007328)1.93777147
100Abnormality of pain sensation (HP:0010832)1.93777147
101Intention tremor (HP:0002080)1.92785486
102Diminished motivation (HP:0000745)1.92740191
103Rapidly progressive (HP:0003678)1.90514723
104Abnormality of ocular smooth pursuit (HP:0000617)1.90479284
105Resting tremor (HP:0002322)1.88879489
106Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88764767
107Degeneration of the lateral corticospinal tracts (HP:0002314)1.88764767
108Oligomenorrhea (HP:0000876)1.87827667
109Incomplete penetrance (HP:0003829)1.87789488
110Gait ataxia (HP:0002066)1.87475175
111Neuronal loss in central nervous system (HP:0002529)1.86748663
112Abnormal EKG (HP:0003115)1.85021751
113Neoplasm of the peripheral nervous system (HP:0100007)1.84719883
114Esotropia (HP:0000565)1.84256435
115Blue irides (HP:0000635)1.84044471
116Akinesia (HP:0002304)1.82607804
117Megalencephaly (HP:0001355)1.82516481
118Rigidity (HP:0002063)1.80684510
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79394297
120Sleep apnea (HP:0010535)1.79197890
121Dysmetric saccades (HP:0000641)1.79082332
122Insulin-resistant diabetes mellitus (HP:0000831)1.75035713
123Spastic tetraplegia (HP:0002510)1.71209499
124Hand muscle atrophy (HP:0009130)1.70065405
125Bundle branch block (HP:0011710)1.68950545
126Split foot (HP:0001839)1.68676979
127Unsteady gait (HP:0002317)1.67063047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.80093648
2EPHA44.29267031
3MAP3K93.75969418
4MAP3K43.20164698
5MAP3K123.01834837
6MINK12.70894808
7MAP2K72.69770311
8MARK12.53086826
9CASK2.27499076
10NTRK12.18688092
11MAP2K42.12611364
12KSR22.11911662
13DAPK22.09084460
14NTRK22.02619184
15RIPK41.99189606
16ARAF1.95249609
17PAK61.91824947
18PNCK1.81532214
19GRK51.71562448
20DAPK11.53065493
21KSR11.52218159
22PLK21.51898385
23CDK51.50112832
24CAMKK11.42423681
25MAP3K131.37617698
26TNIK1.35424752
27FES1.35409597
28PRKD31.35231185
29MAPK131.27779708
30SIK21.26104515
31PRKCG1.24898123
32CDK191.23776747
33UHMK11.15096311
34CAMK2A1.10506617
35RIPK11.05587237
36STK381.03114601
37GRK71.02424071
38MAP3K21.00943009
39FGFR21.00634536
40PHKG20.97646767
41PHKG10.97646767
42INSRR0.95891009
43LATS20.95114216
44CAMKK20.94646434
45CAMK2B0.93404256
46NME10.90937302
47CDK180.90414852
48CDK140.89897700
49CDK150.87563737
50PTK2B0.85771801
51PRPF4B0.85635127
52LMTK20.85438791
53NEK60.82514321
54TYRO30.81870804
55CAMK10.80801055
56RET0.79898192
57CSNK1G20.79778592
58RAF10.79241382
59BMPR20.79162362
60SGK4940.78353331
61SGK2230.78353331
62TNK20.77631997
63PAK30.77163731
64PKN10.76762067
65CAMK1D0.76061416
66CDK11A0.75529819
67CAMK40.74603491
68OXSR10.73858793
69STK110.72727749
70MAP3K10.68687680
71PRKCH0.64213004
72PINK10.64024862
73BRSK10.63916242
74FER0.63847150
75PRKCE0.63748189
76TESK10.63616834
77CAMK2D0.63355913
78DYRK1A0.62333101
79FGR0.61306798
80TAOK10.61193359
81SGK10.61040868
82LIMK10.58733319
83MARK20.58192551
84MAP2K10.58105121
85BRAF0.56587663
86MAPK120.56202012
87SGK20.55377131
88CAMK1G0.55212874
89MAP3K110.55027802
90CAMK2G0.54712857
91PDPK10.52713163
92ADRBK10.52027906
93DYRK20.51531130
94PDK10.48829953
95PRKCZ0.47873581
96MAP3K60.47757656
97MUSK0.44718366
98SIK30.44467585
99CSNK1A1L0.43453662
100WNK30.43249450
101ADRBK20.41784526
102RPS6KA30.41694517
103MAPKAPK50.41174378
104AKT30.37952273
105MAP2K60.37622291
106MAPK100.37186471
107SGK30.37167993
108FYN0.37110754
109ERBB20.36539522
110DAPK30.36488027
111CSNK1G10.36153459
112BCR0.35966317
113PRKAA10.35802983
114ALK0.35378022
115MOS0.34846688
116ROCK20.34621975
117PRKACA0.34359523
118PRKCA0.34032834
119FRK0.33882745
120CSNK1G30.33238267
121CSNK1E0.31708030
122MAPK80.29990020
123CSNK1D0.29876538
124PASK0.29817012
125GSK3B0.29463805

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98679138
2Synaptic vesicle cycle_Homo sapiens_hsa047213.59742653
3GABAergic synapse_Homo sapiens_hsa047272.73702478
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71903951
5Olfactory transduction_Homo sapiens_hsa047402.70455887
6Circadian entrainment_Homo sapiens_hsa047132.57028951
7Amphetamine addiction_Homo sapiens_hsa050312.54431235
8Long-term potentiation_Homo sapiens_hsa047202.52432213
9Morphine addiction_Homo sapiens_hsa050322.51383796
10Glutamatergic synapse_Homo sapiens_hsa047242.43349443
11Dopaminergic synapse_Homo sapiens_hsa047282.24296993
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23392725
13Collecting duct acid secretion_Homo sapiens_hsa049662.14898225
14Salivary secretion_Homo sapiens_hsa049702.07879256
15Taste transduction_Homo sapiens_hsa047421.95553794
16Insulin secretion_Homo sapiens_hsa049111.93346079
17Cocaine addiction_Homo sapiens_hsa050301.87750010
18Cholinergic synapse_Homo sapiens_hsa047251.87401684
19Serotonergic synapse_Homo sapiens_hsa047261.84717828
20Gastric acid secretion_Homo sapiens_hsa049711.80238356
21Renin secretion_Homo sapiens_hsa049241.75625446
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71389270
23Long-term depression_Homo sapiens_hsa047301.70785323
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66672795
25Calcium signaling pathway_Homo sapiens_hsa040201.59797238
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57877274
27Vitamin B6 metabolism_Homo sapiens_hsa007501.56674373
28Oxytocin signaling pathway_Homo sapiens_hsa049211.55909411
29GnRH signaling pathway_Homo sapiens_hsa049121.40723734
30Vibrio cholerae infection_Homo sapiens_hsa051101.38027142
31Cardiac muscle contraction_Homo sapiens_hsa042601.36309754
32Oxidative phosphorylation_Homo sapiens_hsa001901.36131192
33Gap junction_Homo sapiens_hsa045401.34151884
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32671987
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31830405
36cAMP signaling pathway_Homo sapiens_hsa040241.20202731
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11960640
38Parkinsons disease_Homo sapiens_hsa050121.10411414
39Alzheimers disease_Homo sapiens_hsa050101.08251142
40Estrogen signaling pathway_Homo sapiens_hsa049151.08074145
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07982538
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06492923
43Type II diabetes mellitus_Homo sapiens_hsa049301.02280709
44Axon guidance_Homo sapiens_hsa043600.97279140
45Melanogenesis_Homo sapiens_hsa049160.95597867
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95459052
47Glioma_Homo sapiens_hsa052140.95451260
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93137878
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89853295
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.88281665
51ErbB signaling pathway_Homo sapiens_hsa040120.87003563
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.86756708
53Phototransduction_Homo sapiens_hsa047440.84998563
54Oocyte meiosis_Homo sapiens_hsa041140.78875082
55Pancreatic secretion_Homo sapiens_hsa049720.77500700
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75916809
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74001647
58Dorso-ventral axis formation_Homo sapiens_hsa043200.73169032
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72138449
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.71907828
61Thyroid hormone synthesis_Homo sapiens_hsa049180.71070367
62Huntingtons disease_Homo sapiens_hsa050160.68003235
63Dilated cardiomyopathy_Homo sapiens_hsa054140.67985074
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62653649
65Choline metabolism in cancer_Homo sapiens_hsa052310.60685545
66MAPK signaling pathway_Homo sapiens_hsa040100.59956282
67Type I diabetes mellitus_Homo sapiens_hsa049400.59387718
68Glucagon signaling pathway_Homo sapiens_hsa049220.56058196
69Alcoholism_Homo sapiens_hsa050340.53296957
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.51841969
71Regulation of autophagy_Homo sapiens_hsa041400.51397857
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49913954
73Ras signaling pathway_Homo sapiens_hsa040140.48544847
74VEGF signaling pathway_Homo sapiens_hsa043700.48160076
75Prion diseases_Homo sapiens_hsa050200.47536154
76Butanoate metabolism_Homo sapiens_hsa006500.45568048
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.44750669
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44631086
79Rheumatoid arthritis_Homo sapiens_hsa053230.42192238
80Bile secretion_Homo sapiens_hsa049760.41849235
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40658954
82Rap1 signaling pathway_Homo sapiens_hsa040150.40524429
83Fatty acid biosynthesis_Homo sapiens_hsa000610.40174161
84Insulin signaling pathway_Homo sapiens_hsa049100.39714618
85AMPK signaling pathway_Homo sapiens_hsa041520.38104400
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37981492
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36681449
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36134639
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35833061
90Arginine and proline metabolism_Homo sapiens_hsa003300.35398159
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34824118
92Inositol phosphate metabolism_Homo sapiens_hsa005620.34737955
93Ovarian steroidogenesis_Homo sapiens_hsa049130.34190939
94African trypanosomiasis_Homo sapiens_hsa051430.34068421
95Endocytosis_Homo sapiens_hsa041440.33087141
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32701288
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31693786
98beta-Alanine metabolism_Homo sapiens_hsa004100.31178823
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.30768497
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30410056
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30361017
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29367160
103Circadian rhythm_Homo sapiens_hsa047100.29055000
104Nitrogen metabolism_Homo sapiens_hsa009100.28604454
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28130566
106Wnt signaling pathway_Homo sapiens_hsa043100.27806081
107Hippo signaling pathway_Homo sapiens_hsa043900.27568637
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26981262
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26391392
110Tight junction_Homo sapiens_hsa045300.26052038
111Renal cell carcinoma_Homo sapiens_hsa052110.25421077
112Phagosome_Homo sapiens_hsa041450.25130492
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25120324
114Arginine biosynthesis_Homo sapiens_hsa002200.24982414
115mTOR signaling pathway_Homo sapiens_hsa041500.24752549
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23371401

Most similar genes based on co-expression Upload to Enrichr

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