TMEM176A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)6.69306681
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.52575278
3L-phenylalanine metabolic process (GO:0006558)5.52575278
4L-phenylalanine catabolic process (GO:0006559)5.47132217
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.47132217
6phenylpropanoid metabolic process (GO:0009698)5.07086573
7glyoxylate metabolic process (GO:0046487)5.05961494
8aromatic amino acid family catabolic process (GO:0009074)5.03824869
9urate metabolic process (GO:0046415)4.87902774
10omega-hydroxylase P450 pathway (GO:0097267)4.85605424
11drug transmembrane transport (GO:0006855)4.80580347
12cysteine metabolic process (GO:0006534)4.72659064
13indole-containing compound catabolic process (GO:0042436)4.70516864
14indolalkylamine catabolic process (GO:0046218)4.70516864
15tryptophan catabolic process (GO:0006569)4.70516864
16fibrinolysis (GO:0042730)4.55607632
17protein activation cascade (GO:0072376)4.53215451
18tryptophan metabolic process (GO:0006568)4.50861785
19sulfur amino acid catabolic process (GO:0000098)4.45846924
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.43372924
21positive regulation of lipoprotein lipase activity (GO:0051006)4.36625448
22positive regulation of triglyceride lipase activity (GO:0061365)4.36625448
23lysine metabolic process (GO:0006553)4.25690708
24lysine catabolic process (GO:0006554)4.25690708
25blood coagulation, intrinsic pathway (GO:0007597)4.21156646
26kynurenine metabolic process (GO:0070189)4.18404513
27drug transport (GO:0015893)4.11772246
28hormone catabolic process (GO:0042447)4.03881268
29bile acid biosynthetic process (GO:0006699)4.02388226
30alkaloid metabolic process (GO:0009820)4.02134091
31bile acid and bile salt transport (GO:0015721)4.01964678
32valine metabolic process (GO:0006573)4.01929545
33drug catabolic process (GO:0042737)3.91503231
34amino-acid betaine metabolic process (GO:0006577)3.88095470
35regulation of bile acid biosynthetic process (GO:0070857)3.85192903
36alpha-linolenic acid metabolic process (GO:0036109)3.84765389
37oxidative demethylation (GO:0070989)3.84732290
38ethanol metabolic process (GO:0006067)3.84078649
39arginine metabolic process (GO:0006525)3.83784771
40negative regulation of protein activation cascade (GO:2000258)3.81284579
41complement activation, alternative pathway (GO:0006957)3.80042150
42negative regulation of blood coagulation (GO:0030195)3.79737808
43negative regulation of hemostasis (GO:1900047)3.79737808
44angiotensin maturation (GO:0002003)3.77102080
45homocysteine metabolic process (GO:0050667)3.76377685
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.69781556
47negative regulation of complement activation (GO:0045916)3.68956712
48peptidyl-glutamic acid carboxylation (GO:0017187)3.68823992
49protein carboxylation (GO:0018214)3.68823992
50urea metabolic process (GO:0019627)3.68159456
51urea cycle (GO:0000050)3.68159456
52ethanol oxidation (GO:0006069)3.65509116
53serine family amino acid catabolic process (GO:0009071)3.65441507
54aromatic amino acid family metabolic process (GO:0009072)3.65418714
55cholesterol efflux (GO:0033344)3.63801991
56fat-soluble vitamin biosynthetic process (GO:0042362)3.61425556
57exogenous drug catabolic process (GO:0042738)3.60775333
58regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.58212248
59benzene-containing compound metabolic process (GO:0042537)3.56599988
60negative regulation of fibrinolysis (GO:0051918)3.53373317
61regulation of protein activation cascade (GO:2000257)3.53348921
62negative regulation of coagulation (GO:0050819)3.52967373
63antigen processing and presentation of endogenous antigen (GO:0019883)3.51970858
64high-density lipoprotein particle remodeling (GO:0034375)3.51399273
65regulation of humoral immune response (GO:0002920)3.47257165
66nitrogen cycle metabolic process (GO:0071941)3.45108599
67negative regulation of wound healing (GO:0061045)3.43703043
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41590844
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.41590844
70positive regulation of lipid catabolic process (GO:0050996)3.40010103
71regulation of complement activation (GO:0030449)3.37265542
72cellular modified amino acid catabolic process (GO:0042219)3.35755225
73short-chain fatty acid metabolic process (GO:0046459)3.32506987
74regulation of plasminogen activation (GO:0010755)3.32043041
75tricarboxylic acid metabolic process (GO:0072350)3.30762869
76alpha-amino acid catabolic process (GO:1901606)3.30231989
77bile acid metabolic process (GO:0008206)3.30061425
78response to mercury ion (GO:0046689)3.29895773
79regulation of fibrinolysis (GO:0051917)3.29341386
80aminoglycoside antibiotic metabolic process (GO:0030647)3.27972541
81very-low-density lipoprotein particle assembly (GO:0034379)3.27519920
82reverse cholesterol transport (GO:0043691)3.27398992
83indolalkylamine metabolic process (GO:0006586)3.25611669
84flavonoid metabolic process (GO:0009812)3.25317314
85aldehyde catabolic process (GO:0046185)3.25074690
86positive regulation of fatty acid biosynthetic process (GO:0045723)3.24561767
87fatty acid beta-oxidation (GO:0006635)3.22117419
88growth hormone receptor signaling pathway (GO:0060396)3.22082477
89tyrosine metabolic process (GO:0006570)3.21757942
90cellular glucuronidation (GO:0052695)3.20502948
91fatty acid oxidation (GO:0019395)3.20290358
92regulation of cholesterol esterification (GO:0010872)3.20231011
93carnitine metabolic process (GO:0009437)3.20059304
94heme transport (GO:0015886)3.19934108
95acute inflammatory response (GO:0002526)3.19804219
96cellular biogenic amine catabolic process (GO:0042402)3.19167927
97amine catabolic process (GO:0009310)3.19167927
98cellular amino acid catabolic process (GO:0009063)3.18499837
99fructose metabolic process (GO:0006000)3.18108620
100response to growth hormone (GO:0060416)3.17618706
101regulation of cholesterol homeostasis (GO:2000188)3.16920323
102plasma lipoprotein particle organization (GO:0071827)3.16782679
103serine family amino acid metabolic process (GO:0009069)3.14987008
104lipid oxidation (GO:0034440)3.14570988
105response to nitrosative stress (GO:0051409)3.14379897
1062-oxoglutarate metabolic process (GO:0006103)3.13294788
107low-density lipoprotein particle remodeling (GO:0034374)3.13174993
108arginine catabolic process (GO:0006527)3.09986020
109xenobiotic catabolic process (GO:0042178)3.09142500
110branched-chain amino acid metabolic process (GO:0009081)3.08953199
111organic cation transport (GO:0015695)3.07587733
112glucuronate metabolic process (GO:0019585)3.04915632
113uronic acid metabolic process (GO:0006063)3.04915632
114positive regulation of hemostasis (GO:1900048)3.04076811
115positive regulation of blood coagulation (GO:0030194)3.04076811
116steroid catabolic process (GO:0006706)3.02595477
117phospholipid efflux (GO:0033700)3.02266649
118protein-lipid complex subunit organization (GO:0071825)3.02152182
119complement activation, classical pathway (GO:0006958)3.01732472
120plasma lipoprotein particle assembly (GO:0034377)3.00345371
121negative regulation of humoral immune response (GO:0002921)2.99670973
122regulation of triglyceride catabolic process (GO:0010896)2.98240712
123plasma lipoprotein particle remodeling (GO:0034369)2.96095157
124protein-lipid complex remodeling (GO:0034368)2.96095157
125macromolecular complex remodeling (GO:0034367)2.96095157
126carboxylic acid catabolic process (GO:0046395)2.95990445
127organic acid catabolic process (GO:0016054)2.95990445
128positive regulation of coagulation (GO:0050820)2.95188045
129fatty acid catabolic process (GO:0009062)2.94917151
130monocarboxylic acid catabolic process (GO:0072329)2.94057782
131acylglycerol homeostasis (GO:0055090)2.93695804
132triglyceride homeostasis (GO:0070328)2.93695804
133drug metabolic process (GO:0017144)2.93470498
134cellular response to growth hormone stimulus (GO:0071378)2.93167886
135surfactant homeostasis (GO:0043129)2.92319927
136cellular ketone body metabolic process (GO:0046950)2.92047641
137complement activation (GO:0006956)2.91954296
138acute-phase response (GO:0006953)2.89306036
139pyridine nucleotide biosynthetic process (GO:0019363)2.89073348
140nicotinamide nucleotide biosynthetic process (GO:0019359)2.89073348
141glutamate metabolic process (GO:0006536)2.88697190
142negative regulation of sterol transport (GO:0032372)2.87471289
143negative regulation of cholesterol transport (GO:0032375)2.87471289
144lipoprotein metabolic process (GO:0042157)2.87363121
145NADH metabolic process (GO:0006734)2.86321127
146negative regulation of lipase activity (GO:0060192)2.86240935
147xenobiotic metabolic process (GO:0006805)2.85355782
148intestinal absorption (GO:0050892)2.83609065
149plasma lipoprotein particle clearance (GO:0034381)2.83283644
150positive regulation of triglyceride metabolic process (GO:0090208)2.80708702
151cholesterol homeostasis (GO:0042632)2.76757018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.87633064
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.78469285
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.05420737
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.59622397
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.44522699
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.35522399
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.72373756
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.28629546
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.25376831
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63274107
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.57454131
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.41610171
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.31297863
14GATA1_22025678_ChIP-Seq_K562_Human2.30426756
15CLOCK_20551151_ChIP-Seq_293T_Human2.29865855
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.28869916
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.24557213
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.18501424
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.17898320
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14781241
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04228286
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94474642
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84033129
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75897707
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73615517
26SCL_19346495_ChIP-Seq_HPC-7_Human1.58614324
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58561816
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.57860051
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.57701876
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.56265803
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51676689
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.50127534
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.47868609
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44808626
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44186764
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.42788988
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42671347
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41364339
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40483425
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37958073
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35461105
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32226395
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29775884
44SOX2_20726797_ChIP-Seq_SW620_Human1.26446492
45GATA4_25053715_ChIP-Seq_YYC3_Human1.26403776
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.26268429
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24616700
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24252475
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22834211
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20863322
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20811203
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19637612
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19129521
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11268189
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.10399720
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10056932
57LXR_22292898_ChIP-Seq_THP-1_Human1.09449640
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06712237
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05140187
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04892052
61EGR1_19032775_ChIP-ChIP_M12_Human1.03926006
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02497007
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02067105
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00160514
65SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99874875
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99497411
67* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98916036
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98751574
69FOXO3_23340844_ChIP-Seq_DLD1_Human0.96421888
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95436714
71MAF_26560356_Chip-Seq_TH1_Human0.95140442
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94630216
73HNF4A_19822575_ChIP-Seq_HepG2_Human0.93847945
74RUNX_20019798_ChIP-Seq_JUKART_Human0.93014742
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92950940
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91873713
77PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91263123
78RACK7_27058665_Chip-Seq_MCF-7_Human0.90996642
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90991073
80SA1_27219007_Chip-Seq_Bcells_Human0.90592349
81ZNF263_19887448_ChIP-Seq_K562_Human0.90086471
82ELK3_25401928_ChIP-Seq_HUVEC_Human0.89319210
83HTT_18923047_ChIP-ChIP_STHdh_Human0.88709763
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88599985
85VDR_24763502_ChIP-Seq_THP-1_Human0.88123560
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87871069
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87573837
88* BCOR_27268052_Chip-Seq_Bcells_Human0.87188017
89* VDR_24787735_ChIP-Seq_THP-1_Human0.87167706
90DROSHA_22980978_ChIP-Seq_HELA_Human0.86798415
91RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86221043
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82967794
93P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82956382
94GATA6_25053715_ChIP-Seq_YYC3_Human0.82757457
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82721871
96EGR1_19374776_ChIP-ChIP_THP-1_Human0.81839480
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.81298941
98CTCF_27219007_Chip-Seq_Bcells_Human0.81004994
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80634080
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80501597
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80428940
102GATA2_19941826_ChIP-Seq_K562_Human0.80428713
103* BCL6_27268052_Chip-Seq_Bcells_Human0.80426584
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80200040
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80106877
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80014312
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79702018
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79090516
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78595001
110GATA1_19941826_ChIP-Seq_K562_Human0.78081396
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77429768
112* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.76881190
113ERG_21242973_ChIP-ChIP_JURKAT_Human0.75415892
114MYB_26560356_Chip-Seq_TH1_Human0.75103649
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74948166
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74899675
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74899675
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74648876
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74474180
120GATA2_22383799_ChIP-Seq_G1ME_Mouse0.72855925
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.72772065
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72766632
123BCAT_22108803_ChIP-Seq_LS180_Human0.72580467
124MYB_26560356_Chip-Seq_TH2_Human0.72144305
125FOXA1_25552417_ChIP-Seq_VCAP_Human0.71963153
126STAT1_20625510_ChIP-Seq_HELA_Human0.71786837
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71742020
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71404138
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70704980
130VDR_21846776_ChIP-Seq_THP-1_Human0.70414916
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.70251121
132RUNX1_22412390_ChIP-Seq_EML_Mouse0.69800418
133TCF7_22412390_ChIP-Seq_EML_Mouse0.69182716
134TAF2_19829295_ChIP-Seq_ESCs_Human0.68175567
135SPI1_23127762_ChIP-Seq_K562_Human0.67670036
136P300_27268052_Chip-Seq_Bcells_Human0.67615695
137* SOX2_21211035_ChIP-Seq_LN229_Human0.65978384
138CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.64693190
139IKZF1_21737484_ChIP-ChIP_HCT116_Human0.64660409
140SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.64582429
141HNFA_21074721_ChIP-Seq_CACO-2_Human0.64511781
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64453437
143CEBPB_22108803_ChIP-Seq_LS180_Human0.63547048
144E2F1_20622854_ChIP-Seq_HELA_Human0.63436390

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.62305938
2MP0005360_urolithiasis5.50254364
3MP0002138_abnormal_hepatobiliary_system4.52203330
4MP0005365_abnormal_bile_salt3.91974117
5MP0008875_abnormal_xenobiotic_pharmacok3.82318259
6MP0005085_abnormal_gallbladder_physiolo3.80260642
7MP0003252_abnormal_bile_duct2.93280509
8MP0004019_abnormal_vitamin_homeostasis2.65183561
9MP0005332_abnormal_amino_acid2.59717835
10MP0003191_abnormal_cellular_cholesterol2.54118493
11MP0002254_reproductive_system_inflammat2.39480828
12MP0003195_calcinosis2.25710213
13MP0009840_abnormal_foam_cell2.24764807
14MP0010329_abnormal_lipoprotein_level2.21993117
15MP0009643_abnormal_urine_homeostasis2.18724696
16MP0003724_increased_susceptibility_to2.11111104
17MP0000685_abnormal_immune_system1.99462913
18MP0003806_abnormal_nucleotide_metabolis1.97767006
19MP0005083_abnormal_biliary_tract1.92504826
20MP0001835_abnormal_antigen_presentation1.88621390
21MP0003300_gastrointestinal_ulcer1.86510615
22MP0001666_abnormal_nutrient_absorption1.78873063
23MP0010368_abnormal_lymphatic_system1.70924468
24MP0000604_amyloidosis1.64136310
25MP0000609_abnormal_liver_physiology1.63411554
26MP0005319_abnormal_enzyme/_coenzyme1.59017206
27MP0003186_abnormal_redox_activity1.57041235
28MP0005636_abnormal_mineral_homeostasis1.54841812
29MP0009764_decreased_sensitivity_to1.50484362
30MP0009785_altered_susceptibility_to1.50134961
31MP0005584_abnormal_enzyme/coenzyme_acti1.44212138
32MP0002136_abnormal_kidney_physiology1.42281046
33MP0002118_abnormal_lipid_homeostasis1.40745040
34MP0001756_abnormal_urination1.39318929
35MP0003183_abnormal_peptide_metabolism1.37598226
36MP0009697_abnormal_copulation1.35715697
37MP0001765_abnormal_ion_homeostasis1.34219414
38MP0003303_peritoneal_inflammation1.33263967
39MP0008469_abnormal_protein_level1.29691001
40MP0004782_abnormal_surfactant_physiolog1.28099642
41MP0005058_abnormal_lysosome_morphology1.28097271
42MP0003436_decreased_susceptibility_to1.27706374
43MP0003879_abnormal_hair_cell1.25927580
44MP0005387_immune_system_phenotype1.22942286
45MP0001790_abnormal_immune_system1.22942286
46MP0005166_decreased_susceptibility_to1.22883421
47MP0002166_altered_tumor_susceptibility1.21798886
48MP0001958_emphysema1.18607574
49MP0002876_abnormal_thyroid_physiology1.16903169
50MP0004043_abnormal_pH_regulation1.16834704
51MP0005025_abnormal_response_to1.11595361
52MP0001764_abnormal_homeostasis1.11576530
53MP0005084_abnormal_gallbladder_morpholo1.10835156
54MP0002928_abnormal_bile_duct1.09270882
55MP0003172_abnormal_lysosome_physiology1.08985354
56MP0005220_abnormal_exocrine_pancreas1.07906349
57MP0005464_abnormal_platelet_physiology1.07553501
58MP0010155_abnormal_intestine_physiology1.06782940
59MP0010386_abnormal_urinary_bladder1.06489737
60MP0001853_heart_inflammation1.05985379
61MP0000598_abnormal_liver_morphology1.02788159
62MP0001845_abnormal_inflammatory_respons1.02320995
63MP0005451_abnormal_body_composition1.01762804
64MP0002148_abnormal_hypersensitivity_rea1.01696239
65MP0003868_abnormal_feces_composition1.01687864
66MP0005535_abnormal_body_temperature0.99928150
67MP0001879_abnormal_lymphatic_vessel0.98745490
68MP0002419_abnormal_innate_immunity0.97609722
69MP0003638_abnormal_response/metabolism_0.96906087
70MP0004264_abnormal_extraembryonic_tissu0.96667325
71MP0003690_abnormal_glial_cell0.94350271
72MP0009763_increased_sensitivity_to0.93572853
73MP0001873_stomach_inflammation0.93554657
74MP0002971_abnormal_brown_adipose0.93075529
75MP0001501_abnormal_sleep_pattern0.88858974
76MP0003329_amyloid_beta_deposits0.88659837
77MP0009642_abnormal_blood_homeostasis0.86548951
78MP0005671_abnormal_response_to0.82953199
79MP0001800_abnormal_humoral_immune0.78702365
80MP0005000_abnormal_immune_tolerance0.77988342
81MP0003075_altered_response_to0.76491007
82MP0001533_abnormal_skeleton_physiology0.76056095
83MP0009765_abnormal_xenobiotic_induced0.75755913
84MP0006054_spinal_hemorrhage0.74099647
85MP0005376_homeostasis/metabolism_phenot0.74097143
86MP0002723_abnormal_immune_serum0.74016981
87MP0005448_abnormal_energy_balance0.72826407
88MP0002135_abnormal_kidney_morphology0.72680834
89MP0002452_abnormal_antigen_presenting0.72045726
90MP0003011_delayed_dark_adaptation0.71474664
91MP0005647_abnormal_sex_gland0.71338113
92MP0005167_abnormal_blood-brain_barrier0.70807674
93MP0000249_abnormal_blood_vessel0.69580762
94MP0003705_abnormal_hypodermis_morpholog0.69166299
95MP0004947_skin_inflammation0.68878433
96MP0002006_tumorigenesis0.68358374
97MP0002168_other_aberrant_phenotype0.67810978
98MP0005164_abnormal_response_to0.67624905
99MP0008874_decreased_physiological_sensi0.67488528
100MP0010234_abnormal_vibrissa_follicle0.67479903
101MP0009379_abnormal_foot_pigmentation0.65871282
102MP0002998_abnormal_bone_remodeling0.65629479
103MP0002877_abnormal_melanocyte_morpholog0.65229717
104MP0006082_CNS_inflammation0.64853454
105MP0001881_abnormal_mammary_gland0.63549727
106MP0000343_altered_response_to0.63331423
107MP0001663_abnormal_digestive_system0.62694608
108MP0000538_abnormal_urinary_bladder0.61718781
109MP0002909_abnormal_adrenal_gland0.61548545
110MP0001664_abnormal_digestion0.61156678
111MP0005310_abnormal_salivary_gland0.60654387
112MP0001545_abnormal_hematopoietic_system0.60549786
113MP0005397_hematopoietic_system_phenotyp0.60549786
114MP0005670_abnormal_white_adipose0.59861016
115MP0005408_hypopigmentation0.58767634
116MP0000230_abnormal_systemic_arterial0.58671972
117MP0002405_respiratory_system_inflammati0.58436328
118MP0001819_abnormal_immune_cell0.57317030
119MP0002420_abnormal_adaptive_immunity0.56386356
120MP0004510_myositis0.55473907
121MP0002078_abnormal_glucose_homeostasis0.55374629
122MP0005023_abnormal_wound_healing0.54317999
123MP0003866_abnormal_defecation0.54310522
124MP0004883_abnormal_blood_vessel0.50499784
125MP0003953_abnormal_hormone_level0.49618755
126MP0005334_abnormal_fat_pad0.48431227
127MP0005381_digestive/alimentary_phenotyp0.47537776
128MP0009115_abnormal_fat_cell0.44728070

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.30854007
2Abnormality of glutamine family amino acid metabolism (HP:0010902)4.57129479
3Deep venous thrombosis (HP:0002625)4.28495027
4Gout (HP:0001997)4.25393469
5Intrahepatic cholestasis (HP:0001406)4.20397325
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.17375933
7Xanthomatosis (HP:0000991)3.98111888
8Complement deficiency (HP:0004431)3.64568637
9Abnormality of purine metabolism (HP:0004352)3.54528085
10Hyperactive renin-angiotensin system (HP:0000841)3.53217627
11Prolonged partial thromboplastin time (HP:0003645)3.42010009
12Hyperglycinuria (HP:0003108)3.39610184
13Ketosis (HP:0001946)3.37366218
14Hyperammonemia (HP:0001987)3.34080335
15Generalized aminoaciduria (HP:0002909)3.30302455
16Hydroxyprolinuria (HP:0003080)3.27949855
17Abnormality of proline metabolism (HP:0010907)3.27949855
18Abnormality of fatty-acid metabolism (HP:0004359)3.19053926
19Joint hemorrhage (HP:0005261)3.18323935
20Hypokalemic alkalosis (HP:0001949)3.15109950
21Abnormality of nucleobase metabolism (HP:0010932)3.07287353
22Hypoglycemic coma (HP:0001325)3.03252986
23Systemic lupus erythematosus (HP:0002725)3.02853310
24Abnormality of serine family amino acid metabolism (HP:0010894)3.01898584
25Abnormality of glycine metabolism (HP:0010895)3.01898584
26Abnormality of the common coagulation pathway (HP:0010990)3.01629475
27Ketoacidosis (HP:0001993)2.99490826
28Alkalosis (HP:0001948)2.97891303
29Abnormality of chloride homeostasis (HP:0011422)2.93443271
30Hyperlipoproteinemia (HP:0010980)2.93282418
31Proximal tubulopathy (HP:0000114)2.93119145
32Vascular calcification (HP:0004934)2.90738075
33Increased purine levels (HP:0004368)2.90284589
34Hyperuricemia (HP:0002149)2.90284589
35Hypobetalipoproteinemia (HP:0003563)2.89654964
36Purpura (HP:0000979)2.88166143
37Abnormality of liposaccharide metabolism (HP:0010968)2.84927865
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.84927865
39Abnormality of glycolipid metabolism (HP:0010969)2.84927865
40Abnormality of complement system (HP:0005339)2.83546800
41Interstitial pulmonary disease (HP:0006530)2.83487771
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.79105179
43Abnormality of polysaccharide metabolism (HP:0011012)2.79105179
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.79105179
45Abnormality of aspartate family amino acid metabolism (HP:0010899)2.77817587
46Abnormality of the intrinsic pathway (HP:0010989)2.76478631
47Hyperglycinemia (HP:0002154)2.76166603
48Esophageal varix (HP:0002040)2.72747768
49Delayed CNS myelination (HP:0002188)2.70996003
50Cardiovascular calcification (HP:0011915)2.64047694
51Fat malabsorption (HP:0002630)2.63271412
52Vacuolated lymphocytes (HP:0001922)2.62129253
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.60078182
54Hemorrhage of the eye (HP:0011885)2.58660811
55Increased circulating renin level (HP:0000848)2.55948925
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54749036
57Abnormality of renal excretion (HP:0011036)2.54623627
58Dysostosis multiplex (HP:0000943)2.52797329
59Renal salt wasting (HP:0000127)2.49504576
60Potter facies (HP:0002009)2.47863299
61Facial shape deformation (HP:0011334)2.47863299
62Abnormal urine output (HP:0012590)2.45194776
63Abnormality of vitamin metabolism (HP:0100508)2.42640593
64Abnormality of urine glucose concentration (HP:0011016)2.38400019
65Glycosuria (HP:0003076)2.38400019
66Metabolic acidosis (HP:0001942)2.37298204
67Metabolic alkalosis (HP:0200114)2.37275552
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36290316
69Dicarboxylic aciduria (HP:0003215)2.36290316
70Pulmonary embolism (HP:0002204)2.33748600
71Polyuria (HP:0000103)2.33266342
72Glomerulonephritis (HP:0000099)2.30788284
73Hypomagnesemia (HP:0002917)2.29808827
74Hypolipoproteinemia (HP:0010981)2.29357996
75Hepatocellular carcinoma (HP:0001402)2.26574149
76Gingival bleeding (HP:0000225)2.25501868
77Late onset (HP:0003584)2.25071008
78Abnormality of renin-angiotensin system (HP:0000847)2.23614772
79Thrombophlebitis (HP:0004418)2.22456104
80Hypophosphatemia (HP:0002148)2.21477243
81Myocardial infarction (HP:0001658)2.20767741
82Hyperbilirubinemia (HP:0002904)2.20551023
83Conjugated hyperbilirubinemia (HP:0002908)2.19061350
84Hyperaldosteronism (HP:0000859)2.18694040
85Polycythemia (HP:0001901)2.17500521
86Recurrent gram-negative bacterial infections (HP:0005420)2.17452034
87Epidermoid cyst (HP:0200040)2.16725560
88Irritability (HP:0000737)2.16277964
89Hypoalphalipoproteinemia (HP:0003233)2.15391368
90Widely patent fontanelles and sutures (HP:0004492)2.14973097
91Abnormal enzyme/coenzyme activity (HP:0012379)2.14236349
92Abnormality of magnesium homeostasis (HP:0004921)2.13219366
93Amyloidosis (HP:0011034)2.12921658
94Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12823583
95Abnormality of pyrimidine metabolism (HP:0004353)2.12805889
96Nephrolithiasis (HP:0000787)2.12246136
97Pancreatitis (HP:0001733)2.08680643
98Spontaneous abortion (HP:0005268)2.08493974
99Increased serum ferritin (HP:0003281)2.04886014
100Steatorrhea (HP:0002570)2.04423251
101Renal tubular acidosis (HP:0001947)2.04369559
102Abnormality of iron homeostasis (HP:0011031)2.03550259
103Nephritis (HP:0000123)2.03312275
104Abnormality of macrophages (HP:0004311)2.01463767
105Spontaneous hematomas (HP:0007420)1.99618010
106Increased CSF protein (HP:0002922)1.98727612
107Malnutrition (HP:0004395)1.97982130
108Abnormality of alkaline phosphatase activity (HP:0004379)1.96643838
109Tetany (HP:0001281)1.96399660
110Elevated erythrocyte sedimentation rate (HP:0003565)1.95912237
111Hypercholesterolemia (HP:0003124)1.95805292
112Mucopolysacchariduria (HP:0008155)1.95750335
113Urinary glycosaminoglycan excretion (HP:0003541)1.95750335
114Osteomalacia (HP:0002749)1.95566047
115Hyperphosphaturia (HP:0003109)1.94218371
116Eczematoid dermatitis (HP:0000976)1.93488514
117Abnormality of the nasal mucosa (HP:0000433)1.93057894
118Vomiting (HP:0002013)1.92623771
119Mitral stenosis (HP:0001718)1.92545813
120Enlarged kidneys (HP:0000105)1.91610694
121Rickets (HP:0002748)1.91079980
122Menorrhagia (HP:0000132)1.90105524
123Thrombocytosis (HP:0001894)1.88642710
124Lethargy (HP:0001254)1.88611206
125Protuberant abdomen (HP:0001538)1.87326673
126Orchitis (HP:0100796)1.84149969
127Progressive neurologic deterioration (HP:0002344)1.82134329
128Congenital sensorineural hearing impairment (HP:0008527)1.81819096
129Loss of speech (HP:0002371)1.81587466
130Reduced antithrombin III activity (HP:0001976)1.81396674
131Elevated alkaline phosphatase (HP:0003155)1.81041513
132Stroke (HP:0001297)1.79725725
133Abdominal distention (HP:0003270)1.79224810
134Prolonged neonatal jaundice (HP:0006579)1.78472136
135Abnormality of transition element cation homeostasis (HP:0011030)1.77438476
136Abnormality of vitamin B metabolism (HP:0004340)1.77226323
137Nausea (HP:0002018)1.77216904
138Skin nodule (HP:0200036)1.76887407
139Increased cerebral lipofuscin (HP:0011813)1.76275740
140Retinal atrophy (HP:0001105)1.75993940
141Petechiae (HP:0000967)1.74440774
142Abnormal gallbladder physiology (HP:0012438)1.73847287
143Cholecystitis (HP:0001082)1.73847287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.94029338
2BCKDK3.59635840
3ACVR1B3.42354744
4FGFR43.09512261
5TGFBR22.63789051
6TIE12.49450715
7TAOK32.37747113
8TBK12.37255178
9MAP3K142.36553193
10WNK42.35771822
11TYK22.30005179
12FLT32.14537610
13EPHB11.99585577
14KDR1.95354247
15MAPK151.93198870
16NEK91.91658898
17SIK11.91194309
18EPHA31.85394587
19GRK71.78669462
20IKBKE1.77956914
21TRIB31.74259692
22IRAK31.72219332
23JAK31.68419369
24TGFBR11.68071482
25KIT1.66727922
26WNK31.60296444
27DDR21.54438830
28CDC42BPA1.49531347
29ZAP701.48664213
30MAP4K11.48429442
31JAK11.46824824
32PTK61.46569363
33TAOK11.42586913
34IKBKB1.41080214
35FRK1.40820122
36PRPF4B1.36418817
37MAP2K31.34788426
38MYLK1.33002423
39LRRK21.31520403
40MAP3K31.30126978
41MST1R1.29946254
42INSRR1.29418844
43TNK21.27760903
44CHUK1.25509594
45RIPK41.23900609
46TEC1.22610625
47ADRBK21.22317076
48TESK11.20814525
49BTK1.20560811
50PKN21.19110505
51DAPK21.19032219
52IRAK41.17908840
53RIPK11.16919720
54MST41.15227920
55BLK1.12369194
56IRAK11.12057624
57PDPK11.10689769
58OXSR11.05310614
59DYRK1B1.03308122
60JAK21.03022188
61MAP3K20.98008787
62NLK0.96390227
63PIK3CG0.95893555
64PIK3CA0.93219394
65PRKACG0.91196180
66FGFR30.90849824
67PIM20.90207383
68TAOK20.89578697
69NME20.87984226
70MATK0.86515291
71PTK20.85772258
72CSF1R0.84520560
73MAPK110.81920519
74PAK40.81456597
75PDK10.77346098
76PRKG20.74589513
77FER0.74106887
78MAP2K20.71880978
79MAP2K60.71785834
80EPHB20.71565337
81PRKAA20.71181725
82MAP3K70.70121225
83CSK0.69434927
84EPHA20.68070895
85GSK3A0.63582967
86PRKD20.62369282
87MAP3K110.60019854
88MAP3K120.59636717
89MAPK70.57931026
90MAP3K10.57451084
91MAP3K130.53908676
92LATS10.53829241
93NTRK30.53639129
94ABL20.53252391
95PRKCZ0.53027783
96STK38L0.51721502
97PRKCA0.49989323
98PIM10.49331955
99GRK60.49252492
100MAPKAPK30.48613827
101BMPR20.48167621
102TXK0.47809096
103SYK0.47799268
104ITK0.46642287
105PDK20.46114114
106FGR0.43953495
107STK240.43772911
108CDK60.43759903
109SRC0.43206542
110IGF1R0.43016524
111CAMK2D0.42615693
112CAMKK20.41106256
113SCYL20.40759452
114PRKCG0.40135728
115HIPK20.39554351
116PRKCD0.38867893
117PRKCE0.38699704
118LYN0.38657723
119ERBB40.38254515
120RPS6KA40.38015859
121ERBB20.37220509
122MAPK40.37103595
123PRKG10.36422665
124LCK0.35353843
125PDGFRA0.34754016
126STK100.33842562
127FES0.33648421
128PRKACA0.33218419
129NUAK10.33124604
130ABL10.31146032
131RET0.30753904
132GRK10.30136676
133CAMK1D0.29406508
134IRAK20.27676973

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.55410963
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.37444330
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.89979840
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.79626473
5Tryptophan metabolism_Homo sapiens_hsa003802.63607689
6Fatty acid degradation_Homo sapiens_hsa000712.56676284
7Nitrogen metabolism_Homo sapiens_hsa009102.53815427
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50806508
9Complement and coagulation cascades_Homo sapiens_hsa046102.32694135
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22163142
11Peroxisome_Homo sapiens_hsa041462.20616118
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18326896
13Arginine biosynthesis_Homo sapiens_hsa002202.15373274
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09754476
15Histidine metabolism_Homo sapiens_hsa003401.94962269
16Chemical carcinogenesis_Homo sapiens_hsa052041.89869676
17Butanoate metabolism_Homo sapiens_hsa006501.89269695
18Caffeine metabolism_Homo sapiens_hsa002321.86706356
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84846531
20Propanoate metabolism_Homo sapiens_hsa006401.83408643
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82811837
22Linoleic acid metabolism_Homo sapiens_hsa005911.77855590
23Staphylococcus aureus infection_Homo sapiens_hsa051501.76813414
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.73956153
25Sulfur metabolism_Homo sapiens_hsa009201.73866774
26beta-Alanine metabolism_Homo sapiens_hsa004101.68646717
27PPAR signaling pathway_Homo sapiens_hsa033201.64810229
28Fatty acid metabolism_Homo sapiens_hsa012121.61409529
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.57156516
30Folate biosynthesis_Homo sapiens_hsa007901.51516506
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.48293678
32Retinol metabolism_Homo sapiens_hsa008301.46887819
33Selenocompound metabolism_Homo sapiens_hsa004501.45282967
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.45109582
35Vitamin digestion and absorption_Homo sapiens_hsa049771.39727244
36Phenylalanine metabolism_Homo sapiens_hsa003601.38303400
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35429465
38Bile secretion_Homo sapiens_hsa049761.34524934
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30128821
40Starch and sucrose metabolism_Homo sapiens_hsa005001.30078306
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29563245
42Pyruvate metabolism_Homo sapiens_hsa006201.25984763
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18707194
44Glutathione metabolism_Homo sapiens_hsa004801.14417479
45Sulfur relay system_Homo sapiens_hsa041221.13301687
46Tyrosine metabolism_Homo sapiens_hsa003501.10540606
47ABC transporters_Homo sapiens_hsa020101.10352545
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05349373
49Mineral absorption_Homo sapiens_hsa049781.02612850
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00305792
51Other glycan degradation_Homo sapiens_hsa005110.97946119
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95715207
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95044832
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93042928
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92849777
56Arginine and proline metabolism_Homo sapiens_hsa003300.92279606
57Fatty acid elongation_Homo sapiens_hsa000620.89475649
58Carbon metabolism_Homo sapiens_hsa012000.85792755
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.85609539
60Fat digestion and absorption_Homo sapiens_hsa049750.72498970
61Biosynthesis of amino acids_Homo sapiens_hsa012300.68593065
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.68262008
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.63958578
64Glycerolipid metabolism_Homo sapiens_hsa005610.63161877
65Lysine degradation_Homo sapiens_hsa003100.62710343
66Asthma_Homo sapiens_hsa053100.60482603
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59392947
68Pentose phosphate pathway_Homo sapiens_hsa000300.59309207
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59085366
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.56398639
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55664191
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54084643
73Type I diabetes mellitus_Homo sapiens_hsa049400.53736624
74Steroid biosynthesis_Homo sapiens_hsa001000.53516220
75Lysosome_Homo sapiens_hsa041420.51427916
76Allograft rejection_Homo sapiens_hsa053300.50704930
77Leishmaniasis_Homo sapiens_hsa051400.47536533
78Galactose metabolism_Homo sapiens_hsa000520.46444325
79Sphingolipid metabolism_Homo sapiens_hsa006000.43785092
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42192914
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41579368
82Vitamin B6 metabolism_Homo sapiens_hsa007500.41381660
83Antigen processing and presentation_Homo sapiens_hsa046120.41054222
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.40415417
85Autoimmune thyroid disease_Homo sapiens_hsa053200.39478246
86Pertussis_Homo sapiens_hsa051330.39451931
87Graft-versus-host disease_Homo sapiens_hsa053320.39411901
88Protein export_Homo sapiens_hsa030600.38882217
89Insulin resistance_Homo sapiens_hsa049310.36535282
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.36170915
91Metabolic pathways_Homo sapiens_hsa011000.36149117
92Malaria_Homo sapiens_hsa051440.34353134
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33316577
94Fructose and mannose metabolism_Homo sapiens_hsa000510.31808589
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31476927
96Protein digestion and absorption_Homo sapiens_hsa049740.30178809
97TNF signaling pathway_Homo sapiens_hsa046680.29670705
98Arachidonic acid metabolism_Homo sapiens_hsa005900.29378450
99Rheumatoid arthritis_Homo sapiens_hsa053230.29266397
100Toxoplasmosis_Homo sapiens_hsa051450.29045616
101Osteoclast differentiation_Homo sapiens_hsa043800.27189963
102Ether lipid metabolism_Homo sapiens_hsa005650.25662835
103African trypanosomiasis_Homo sapiens_hsa051430.25520539
104Hepatitis C_Homo sapiens_hsa051600.25447537
105One carbon pool by folate_Homo sapiens_hsa006700.24675238
106Legionellosis_Homo sapiens_hsa051340.24537856
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24083782
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19873231
109Measles_Homo sapiens_hsa051620.18760049
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.17550566
111Amoebiasis_Homo sapiens_hsa051460.16911373
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.16707622
113Renin-angiotensin system_Homo sapiens_hsa046140.16602439
114Prion diseases_Homo sapiens_hsa050200.16131756
115Phagosome_Homo sapiens_hsa041450.15414074
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15170053
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15031011
118Tuberculosis_Homo sapiens_hsa051520.14800571
119N-Glycan biosynthesis_Homo sapiens_hsa005100.14717169
120Glucagon signaling pathway_Homo sapiens_hsa049220.13647982

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