TMEM173

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.41743986
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.41743986
3antigen processing and presentation of endogenous antigen (GO:0019883)6.23638626
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.63894623
5positive regulation of gamma-delta T cell activation (GO:0046645)5.07185077
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.59819214
7regulation of B cell receptor signaling pathway (GO:0050855)4.35158007
8positive regulation of B cell differentiation (GO:0045579)4.18844995
9immunoglobulin mediated immune response (GO:0016064)4.18780485
10regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.08381330
11antigen processing and presentation via MHC class Ib (GO:0002475)3.91748923
12regulation of B cell differentiation (GO:0045577)3.81578653
13ribosomal small subunit assembly (GO:0000028)3.71766028
14regulation of gamma-delta T cell differentiation (GO:0045586)3.71622068
15detection of bacterium (GO:0016045)3.62899434
16response to peptidoglycan (GO:0032494)3.62061046
17mast cell activation (GO:0045576)3.60004863
18regulation of interleukin-12 biosynthetic process (GO:0045075)3.59199608
19Arp2/3 complex-mediated actin nucleation (GO:0034314)3.58503063
20myeloid dendritic cell activation (GO:0001773)3.56982375
21detection of other organism (GO:0098543)3.56839033
22response to type I interferon (GO:0034340)3.55590986
23cellular response to type I interferon (GO:0071357)3.55500301
24type I interferon signaling pathway (GO:0060337)3.55500301
25B cell mediated immunity (GO:0019724)3.51782584
26NIK/NF-kappaB signaling (GO:0038061)3.49079775
27B cell receptor signaling pathway (GO:0050853)3.47682321
28regulation of gamma-delta T cell activation (GO:0046643)3.46785658
29negative regulation of phagocytosis (GO:0050765)3.46217732
30negative thymic T cell selection (GO:0045060)3.45021461
31regulation of interferon-beta biosynthetic process (GO:0045357)3.43476974
32interferon-gamma-mediated signaling pathway (GO:0060333)3.40258433
33regulation of dendritic cell antigen processing and presentation (GO:0002604)3.39072114
34positive regulation of granulocyte differentiation (GO:0030854)3.38047460
35negative T cell selection (GO:0043383)3.37314525
36positive regulation of tolerance induction (GO:0002645)3.36663357
37myeloid dendritic cell differentiation (GO:0043011)3.27456157
38response to interleukin-15 (GO:0070672)3.26688362
39positive regulation of antigen processing and presentation (GO:0002579)3.26019777
40regulation of tolerance induction (GO:0002643)3.24516911
41leukocyte aggregation (GO:0070486)3.22764894
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.21968507
43tolerance induction (GO:0002507)3.21567389
44T cell selection (GO:0045058)3.19897279
45positive regulation of interferon-alpha production (GO:0032727)3.19175890
46defense response to protozoan (GO:0042832)3.18923547
47response to protozoan (GO:0001562)3.18415449
48regulation of germinal center formation (GO:0002634)3.17776023
49cellular response to zinc ion (GO:0071294)3.16983410
50regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.16863113
51T cell migration (GO:0072678)3.16212955
52positive T cell selection (GO:0043368)3.15076915
53negative regulation of leukocyte mediated immunity (GO:0002704)3.14501595
54* response to interferon-beta (GO:0035456)3.14393379
55positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.13827767
56negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11670641
57neutrophil activation involved in immune response (GO:0002283)3.06154269
58regulation of interferon-alpha production (GO:0032647)3.04394590
59T cell homeostasis (GO:0043029)3.03996446
60interferon-gamma production (GO:0032609)3.03934286
61negative regulation of T cell mediated immunity (GO:0002710)3.03791072
62mature B cell differentiation (GO:0002335)3.00845163
63definitive hemopoiesis (GO:0060216)3.00561331
64pinocytosis (GO:0006907)2.99845947
65positive thymic T cell selection (GO:0045059)2.97882129
66viral transcription (GO:0019083)2.95816172
67regulation of antigen processing and presentation (GO:0002577)2.95464961
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94474786
69mature B cell differentiation involved in immune response (GO:0002313)2.93610964
70positive regulation of natural killer cell differentiation (GO:0032825)2.93379338
71* cellular response to interferon-beta (GO:0035458)2.91745186
72positive regulation of isotype switching (GO:0045830)2.90847404
73regulation of T cell receptor signaling pathway (GO:0050856)2.89331152
74dendritic cell differentiation (GO:0097028)2.87772005
75regulation of mast cell degranulation (GO:0043304)2.86293483
76Peyers patch development (GO:0048541)2.85947084
77mucosal-associated lymphoid tissue development (GO:0048537)2.85947084
78positive regulation of macrophage differentiation (GO:0045651)2.84613831
79positive regulation by symbiont of host defense response (GO:0052509)2.84230220
80modulation by symbiont of host defense response (GO:0052031)2.84230220
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84230220
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84230220
83positive regulation by organism of defense response of other organism involved in symbiotic interact2.84230220
84modulation by symbiont of host immune response (GO:0052553)2.84230220
85negative regulation of T-helper cell differentiation (GO:0045623)2.84201996
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.84201996
87regulation of type I interferon-mediated signaling pathway (GO:0060338)2.83758220
88regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83741315
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.81789857
90negative regulation of interleukin-6 production (GO:0032715)2.81750137
91regulation of T cell tolerance induction (GO:0002664)2.81618024
92regulation of necroptotic process (GO:0060544)2.81075829
93translational termination (GO:0006415)2.80189980
94negative regulation of innate immune response (GO:0045824)2.80007718
95respiratory burst (GO:0045730)2.79631998
96mast cell degranulation (GO:0043303)2.79536986
97mast cell activation involved in immune response (GO:0002279)2.79536986
98regulation of granulocyte differentiation (GO:0030852)2.78832465
99angiogenesis involved in wound healing (GO:0060055)2.77522316
100regulation of alpha-beta T cell proliferation (GO:0046640)2.77160605
101cellular response to interleukin-15 (GO:0071350)2.76806728
102mannose metabolic process (GO:0006013)2.76190265
103germinal center formation (GO:0002467)2.75851889
104lymphocyte homeostasis (GO:0002260)2.75030970
105positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.73674398
106JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.73447272
107myeloid cell activation involved in immune response (GO:0002275)2.73211006
108regulation of T-helper 1 cell differentiation (GO:0045625)2.73207900
109response to muramyl dipeptide (GO:0032495)2.72792340
110lymph node development (GO:0048535)2.70966956
111negative regulation of granulocyte differentiation (GO:0030853)2.70889971
112negative regulation of interleukin-8 production (GO:0032717)2.70760860
113leukocyte degranulation (GO:0043299)2.70430242
114negative regulation of interleukin-12 production (GO:0032695)2.69705786
115neutrophil activation (GO:0042119)2.67890217
116regulation of leukocyte degranulation (GO:0043300)2.67759964
117positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.67194554
118cilium or flagellum-dependent cell motility (GO:0001539)2.66983207
119antigen receptor-mediated signaling pathway (GO:0050851)2.66607635
120thymic T cell selection (GO:0045061)2.66535497
121negative regulation of erythrocyte differentiation (GO:0045647)2.66299892
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.65924126
123negative regulation of cell killing (GO:0031342)2.65924126
124detection of external biotic stimulus (GO:0098581)2.65759224
125regulation of response to interferon-gamma (GO:0060330)2.65326140
126response to interferon-alpha (GO:0035455)2.65254843
127regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.62747668
128regulation of natural killer cell mediated immunity (GO:0002715)2.62747668
129leukocyte homeostasis (GO:0001776)2.59888149
130cellular extravasation (GO:0045123)2.59371452
131negative regulation of nitric oxide biosynthetic process (GO:0045019)2.59126121
132SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.58540807
133macrophage activation involved in immune response (GO:0002281)2.58183463
134positive regulation of natural killer cell mediated immunity (GO:0002717)2.57879848
135positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.57879848
136actin nucleation (GO:0045010)2.57314925
137regulation of regulatory T cell differentiation (GO:0045589)2.57084334
138natural killer cell activation (GO:0030101)2.57070856
139regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.56771806
140axonemal dynein complex assembly (GO:0070286)2.55733871
141regulation of mast cell activation involved in immune response (GO:0033006)2.55310608
142positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.54861716
143regulation of T cell mediated cytotoxicity (GO:0001914)2.53102230
144negative regulation of cytokine production involved in immune response (GO:0002719)2.52817939
145negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.51414718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.94782127
2E2F7_22180533_ChIP-Seq_HELA_Human4.45410949
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.36854875
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.92889124
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.89883390
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.69097684
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.40479798
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37746359
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.12590917
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.01696667
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82549207
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.73588498
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.72892686
14MYC_22102868_ChIP-Seq_BL_Human2.70373923
15SCL_19346495_ChIP-Seq_HPC-7_Human2.66881852
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.63147053
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.61077036
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57519626
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.55894965
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54626502
21* VDR_21846776_ChIP-Seq_THP-1_Human2.53798976
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46287231
23* MYB_26560356_Chip-Seq_TH2_Human2.43673085
24SPI1_23547873_ChIP-Seq_NB4_Human2.37738412
25MAF_26560356_Chip-Seq_TH1_Human2.31691204
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21954982
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09402498
28MYB_26560356_Chip-Seq_TH1_Human2.09371560
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08093434
30RUNX_20019798_ChIP-Seq_JUKART_Human2.05550954
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04755913
32* VDR_24763502_ChIP-Seq_THP-1_Human2.04647755
33* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04603203
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98997306
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97718691
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96798856
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.96307950
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.94283180
39UTX_26944678_Chip-Seq_JUKART_Human1.85602474
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79219848
41LXR_22292898_ChIP-Seq_THP-1_Human1.76576064
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75345758
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74911397
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66223592
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63381677
46* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62763650
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62654610
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.57048659
49* TCF7_22412390_ChIP-Seq_EML_Mouse1.55971576
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53738059
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53434119
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.52935266
53SPI1_23127762_ChIP-Seq_K562_Human1.52413673
54BCL6_27268052_Chip-Seq_Bcells_Human1.45276322
55GATA1_19941826_ChIP-Seq_K562_Human1.45033931
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44976043
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43985465
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.43973022
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43796372
60MAF_26560356_Chip-Seq_TH2_Human1.43014082
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41087397
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40168967
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39693681
64GATA3_27048872_Chip-Seq_THYMUS_Human1.38094801
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35618115
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.35268106
67PU_27001747_Chip-Seq_BMDM_Mouse1.33366088
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31187230
69VDR_24787735_ChIP-Seq_THP-1_Human1.31103736
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30671798
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27364689
72GATA1_22025678_ChIP-Seq_K562_Human1.27113050
73CIITA_25753668_ChIP-Seq_RAJI_Human1.26974920
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.26595612
75VDR_23849224_ChIP-Seq_CD4+_Human1.25448797
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.21211399
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21057147
78BCOR_27268052_Chip-Seq_Bcells_Human1.20716002
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20511591
80NCOR1_26117541_ChIP-Seq_K562_Human1.20477263
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17939240
82P68_20966046_ChIP-Seq_HELA_Human1.16312471
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.15351042
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14364449
85FOXP3_21729870_ChIP-Seq_TREG_Human1.12886746
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12221507
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11914087
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08968510
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08884574
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08815283
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07791730
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06223003
93GATA3_26560356_Chip-Seq_TH2_Human1.04653325
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.03145732
95* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02460702
96* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02376401
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01958865
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01843466
99RACK7_27058665_Chip-Seq_MCF-7_Human1.01755765
100STAT1_20625510_ChIP-Seq_HELA_Human1.00861058
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00080760
102SPI1_20517297_ChIP-Seq_HL60_Human0.98688461
103P300_27268052_Chip-Seq_Bcells_Human0.96716262
104CTCF_26484167_Chip-Seq_Bcells_Mouse0.96715206
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96152013
106GATA2_19941826_ChIP-Seq_K562_Human0.95835016
107* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95553407
108GABP_17652178_ChIP-ChIP_JURKAT_Human0.94928626
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94881813
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94449857
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94266612
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92651204
113KDM2B_26808549_Chip-Seq_DND41_Human0.92587171
114VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92482351
115XRN2_22483619_ChIP-Seq_HELA_Human0.91126317
116TFEB_21752829_ChIP-Seq_HELA_Human0.90641335
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90612785
118EST1_17652178_ChIP-ChIP_JURKAT_Human0.90596042
119MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90369897
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89465628
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88830083
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88687659
123ELK1_19687146_ChIP-ChIP_HELA_Human0.87256653
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.83163894
125E2F1_21310950_ChIP-Seq_MCF-7_Human0.82665108
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82575019
127MYC_19079543_ChIP-ChIP_MESCs_Mouse0.80788814
128FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80342096
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77079582
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75937809

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.74020987
2MP0005671_abnormal_response_to3.58551394
3MP0000685_abnormal_immune_system3.55991312
4MP0009785_altered_susceptibility_to3.10963578
5MP0002396_abnormal_hematopoietic_system3.08454858
6MP0001800_abnormal_humoral_immune2.97844639
7MP0003763_abnormal_thymus_physiology2.92774480
8MP0003436_decreased_susceptibility_to2.90593686
9MP0005387_immune_system_phenotype2.86263840
10MP0001790_abnormal_immune_system2.86263840
11MP0005000_abnormal_immune_tolerance2.85474007
12MP0002452_abnormal_antigen_presenting2.74697319
13MP0002148_abnormal_hypersensitivity_rea2.71315094
14* MP0005025_abnormal_response_to2.70467441
15MP0002723_abnormal_immune_serum2.65491511
16MP0002420_abnormal_adaptive_immunity2.60251728
17MP0001819_abnormal_immune_cell2.58347450
18MP0003724_increased_susceptibility_to2.49805248
19* MP0002419_abnormal_innate_immunity2.46360583
20MP0002398_abnormal_bone_marrow2.37395601
21MP0002166_altered_tumor_susceptibility2.34829026
22MP0006082_CNS_inflammation2.20029648
23MP0009333_abnormal_splenocyte_physiolog2.17940797
24MP0000716_abnormal_immune_system2.17889861
25MP0003303_peritoneal_inflammation2.17558288
26MP0001853_heart_inflammation2.10266500
27MP0005464_abnormal_platelet_physiology2.07741235
28MP0002405_respiratory_system_inflammati2.07154475
29MP0001873_stomach_inflammation2.01005216
30MP0000689_abnormal_spleen_morphology2.00667985
31MP0010155_abnormal_intestine_physiology2.00507592
32MP0002722_abnormal_immune_system1.93775111
33MP0002006_tumorigenesis1.93117826
34MP0004808_abnormal_hematopoietic_stem1.91200362
35MP0002429_abnormal_blood_cell1.86829607
36MP0001845_abnormal_inflammatory_respons1.74133834
37MP0003300_gastrointestinal_ulcer1.71986439
38MP0005397_hematopoietic_system_phenotyp1.70628412
39MP0001545_abnormal_hematopoietic_system1.70628412
40MP0000465_gastrointestinal_hemorrhage1.64879942
41MP0003866_abnormal_defecation1.63339383
42MP0000703_abnormal_thymus_morphology1.62465732
43MP0004947_skin_inflammation1.57660048
44MP0000490_abnormal_crypts_of1.55371051
45MP0004510_myositis1.55097954
46MP0001533_abnormal_skeleton_physiology1.53668278
47MP0000858_altered_metastatic_potential1.47835931
48MP0002933_joint_inflammation1.38854812
49MP0008469_abnormal_protein_level1.37220141
50MP0009278_abnormal_bone_marrow1.35922190
51MP0005310_abnormal_salivary_gland1.35465227
52MP0005058_abnormal_lysosome_morphology1.32562214
53MP0006054_spinal_hemorrhage1.28514213
54MP0008007_abnormal_cellular_replicative1.27788768
55MP0001958_emphysema1.25575898
56MP0003448_altered_tumor_morphology1.24735097
57MP0005164_abnormal_response_to1.22329589
58MP0003806_abnormal_nucleotide_metabolis1.20631064
59MP0008260_abnormal_autophagy1.17679351
60MP0008438_abnormal_cutaneous_collagen1.17438173
61MP0003191_abnormal_cellular_cholesterol1.15382642
62MP0000343_altered_response_to1.14935453
63MP0003172_abnormal_lysosome_physiology1.13733242
64MP0005075_abnormal_melanosome_morpholog1.13244733
65MP0004883_abnormal_blood_vessel1.11300885
66MP0005174_abnormal_tail_pigmentation1.10256546
67MP0001542_abnormal_bone_strength1.05601979
68MP0002019_abnormal_tumor_incidence1.04037503
69MP0005165_increased_susceptibility_to1.03909567
70MP0003693_abnormal_embryo_hatching1.03438149
71MP0001851_eye_inflammation1.01421846
72MP0009764_decreased_sensitivity_to0.98288196
73MP0010352_gastrointestinal_tract_polyps0.97346355
74MP0010094_abnormal_chromosome_stability0.90076231
75MP0003656_abnormal_erythrocyte_physiolo0.87380584
76MP0003828_pulmonary_edema0.86574338
77MP0003077_abnormal_cell_cycle0.86214233
78MP0005023_abnormal_wound_healing0.83789247
79MP0005503_abnormal_tendon_morphology0.83284670
80MP0005451_abnormal_body_composition0.83052686
81MP0000681_abnormal_thyroid_gland0.81734477
82MP0000249_abnormal_blood_vessel0.77930326
83MP0002095_abnormal_skin_pigmentation0.77600855
84MP0002998_abnormal_bone_remodeling0.76520967
85MP0003183_abnormal_peptide_metabolism0.76450943
86MP0008058_abnormal_DNA_repair0.75875008
87MP0004782_abnormal_surfactant_physiolog0.75794848
88MP0003045_fibrosis0.75397657
89MP0008004_abnormal_stomach_pH0.75246963
90MP0009763_increased_sensitivity_to0.75176255
91MP0005390_skeleton_phenotype0.74027414
92MP0002009_preneoplasia0.71862257
93MP0008057_abnormal_DNA_replication0.71378518
94MP0010307_abnormal_tumor_latency0.69859752
95MP0003075_altered_response_to0.69634774
96MP0003279_aneurysm0.69445793
97MP0001663_abnormal_digestive_system0.68615315
98MP0003566_abnormal_cell_adhesion0.65044796
99MP0000015_abnormal_ear_pigmentation0.65014071
100MP0002277_abnormal_respiratory_mucosa0.64269593
101MP0000604_amyloidosis0.63896319
102MP0000313_abnormal_cell_death0.62937115
103MP0002254_reproductive_system_inflammat0.61301112
104MP0005166_decreased_susceptibility_to0.59758880
105MP0001879_abnormal_lymphatic_vessel0.59492282
106MP0009765_abnormal_xenobiotic_induced0.59276008
107MP0003795_abnormal_bone_structure0.58727155
108MP0005083_abnormal_biliary_tract0.58348849
109MP0005275_abnormal_skin_tensile0.58334461
110MP0000477_abnormal_intestine_morphology0.57504698
111MP0003943_abnormal_hepatobiliary_system0.57269734
112MP0008873_increased_physiological_sensi0.56780296
113MP0001348_abnormal_lacrimal_gland0.56626511
114MP0010368_abnormal_lymphatic_system0.56430227
115MP0002132_abnormal_respiratory_system0.55915328
116MP0000371_diluted_coat_color0.54906452
117MP0002133_abnormal_respiratory_system0.54090476
118MP0009840_abnormal_foam_cell0.51504924
119MP0002136_abnormal_kidney_physiology0.51359303
120MP0003091_abnormal_cell_migration0.50661031
121MP0000767_abnormal_smooth_muscle0.50286571
122MP0004957_abnormal_blastocyst_morpholog0.46832412

Predicted human phenotypes

RankGene SetZ-score
1* Elevated erythrocyte sedimentation rate (HP:0003565)4.92148774
2Recurrent abscess formation (HP:0002722)4.85250057
3Chronic otitis media (HP:0000389)4.73537152
4IgM deficiency (HP:0002850)4.61505005
5Recurrent bacterial skin infections (HP:0005406)4.37066235
6Eczematoid dermatitis (HP:0000976)4.33557957
7* Myositis (HP:0100614)4.32497985
8Recurrent bronchitis (HP:0002837)4.26642786
9Recurrent viral infections (HP:0004429)3.93457401
10Recurrent fungal infections (HP:0002841)3.82532685
11Panhypogammaglobulinemia (HP:0003139)3.56092525
12Abnormality of T cell physiology (HP:0011840)3.55028795
13Orchitis (HP:0100796)3.52839863
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.48957703
15Meningitis (HP:0001287)3.47916401
16Recurrent skin infections (HP:0001581)3.43637528
17Chronic mucocutaneous candidiasis (HP:0002728)3.40203042
18Recurrent cutaneous fungal infections (HP:0011370)3.40203042
19Abnormality of T cells (HP:0002843)3.39983091
20Nasal polyposis (HP:0100582)3.33682800
21Agammaglobulinemia (HP:0004432)3.30226157
22Absent/shortened dynein arms (HP:0200106)3.27406213
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.27406213
24* Thrombocytosis (HP:0001894)3.27372191
25Retrobulbar optic neuritis (HP:0100654)3.26139100
26Optic neuritis (HP:0100653)3.26139100
27B lymphocytopenia (HP:0010976)3.25859116
28Abnormality of B cell number (HP:0010975)3.25859116
29Vasculitis (HP:0002633)3.24606023
30Inflammation of the large intestine (HP:0002037)3.23917828
31Abnormality of the nasal mucosa (HP:0000433)3.23355331
32Cellulitis (HP:0100658)3.22110658
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.17679286
34Gastrointestinal inflammation (HP:0004386)3.16394257
35Pustule (HP:0200039)3.11805904
36Colitis (HP:0002583)3.08215571
37Mediastinal lymphadenopathy (HP:0100721)3.07584408
38Abnormal respiratory epithelium morphology (HP:0012253)3.02456798
39Abnormal respiratory motile cilium morphology (HP:0005938)3.02456798
40Abnormality of macrophages (HP:0004311)3.01474886
41Petechiae (HP:0000967)2.99720772
42Chronic obstructive pulmonary disease (HP:0006510)2.96003368
43Obstructive lung disease (HP:0006536)2.96003368
44IgG deficiency (HP:0004315)2.95515355
45Autoimmune thrombocytopenia (HP:0001973)2.94521349
46Abnormality of T cell number (HP:0011839)2.93394558
47Lymphopenia (HP:0001888)2.92608431
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.89222522
49Gastrointestinal stroma tumor (HP:0100723)2.88896129
50Spontaneous hematomas (HP:0007420)2.86781175
51T lymphocytopenia (HP:0005403)2.85869642
52Abnormal respiratory motile cilium physiology (HP:0012261)2.81251566
53Abnormal ciliary motility (HP:0012262)2.79249831
54Chronic diarrhea (HP:0002028)2.72384269
55Eosinophilia (HP:0001880)2.71634078
56Systemic lupus erythematosus (HP:0002725)2.66770480
57Aplastic anemia (HP:0001915)2.61803056
58IgA deficiency (HP:0002720)2.61765226
59Chronic sinusitis (HP:0011109)2.59233418
60Granulocytopenia (HP:0001913)2.58882125
61Leukocytosis (HP:0001974)2.58046603
62Hematochezia (HP:0002573)2.56840362
63Emphysema (HP:0002097)2.55458311
64Pulmonary infiltrates (HP:0002113)2.55183161
65Recurrent sinusitis (HP:0011108)2.53490392
66Recurrent gram-negative bacterial infections (HP:0005420)2.52897519
67Stomatitis (HP:0010280)2.50795199
68Vacuolated lymphocytes (HP:0001922)2.50656469
69Autoimmune hemolytic anemia (HP:0001890)2.49387172
70Arterial thrombosis (HP:0004420)2.47695270
71Hemoptysis (HP:0002105)2.46963194
72Encephalitis (HP:0002383)2.44688109
73Abnormality of eosinophils (HP:0001879)2.42964551
74Lymphoma (HP:0002665)2.42236278
75Keratoconjunctivitis (HP:0001096)2.40001297
76Thyroiditis (HP:0100646)2.38503132
77Keratoconjunctivitis sicca (HP:0001097)2.38398964
78Gastrointestinal infarctions (HP:0005244)2.37608601
79Bronchiectasis (HP:0002110)2.36699387
80Polygenic inheritance (HP:0010982)2.34599244
81Amyloidosis (HP:0011034)2.34084148
82Severe combined immunodeficiency (HP:0004430)2.33752248
83Reticulocytopenia (HP:0001896)2.32776711
84Recurrent pneumonia (HP:0006532)2.32407304
85Abnormality of the fingertips (HP:0001211)2.31046881
86Basal ganglia calcification (HP:0002135)2.31037593
87Hypertensive crisis (HP:0100735)2.30731695
88Spondylolisthesis (HP:0003302)2.29883004
89Osteomyelitis (HP:0002754)2.27750223
90Recurrent lower respiratory tract infections (HP:0002783)2.25558490
91Increased serum ferritin (HP:0003281)2.23444209
92Chest pain (HP:0100749)2.22806962
93Increased IgE level (HP:0003212)2.22285750
94Bronchitis (HP:0012387)2.22256482
95Rhinitis (HP:0012384)2.21338388
96Skin ulcer (HP:0200042)2.21056844
97Epistaxis (HP:0000421)2.19971911
98Combined immunodeficiency (HP:0005387)2.18226829
99Periodontitis (HP:0000704)2.16012558
100Prolonged bleeding time (HP:0003010)2.15842551
101Abnormality of glycolipid metabolism (HP:0010969)2.13192575
102Abnormality of liposaccharide metabolism (HP:0010968)2.13192575
103Abnormality of glycosphingolipid metabolism (HP:0004343)2.13192575
104Increased IgM level (HP:0003496)2.12950826
105* Hypergammaglobulinemia (HP:0010702)2.10557737
106Increased neuronal autofluorescent lipopigment (HP:0002074)2.04213848
107Episodic fever (HP:0001954)2.04025142
108Increased cerebral lipofuscin (HP:0011813)2.02185554
109Dysostosis multiplex (HP:0000943)2.01797778
110Abnormality of the prostate (HP:0008775)1.99580196
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99496089
112Abnormality of polysaccharide metabolism (HP:0011012)1.99496089
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99496089
114Aortic aneurysm (HP:0004942)1.99295925
115Protrusio acetabuli (HP:0003179)1.98915189
116Abnormality of iron homeostasis (HP:0011031)1.97520777
117Reduced antithrombin III activity (HP:0001976)1.97444572
118Polycythemia (HP:0001901)1.95966255
119Mucopolysacchariduria (HP:0008155)1.95414287
120Urinary glycosaminoglycan excretion (HP:0003541)1.95414287
121Purpura (HP:0000979)1.94046244
122Hepatosplenomegaly (HP:0001433)1.93762585
123Gingival bleeding (HP:0000225)1.93556617
124Abnormality of the pleura (HP:0002103)1.93519049
125Urticaria (HP:0001025)1.91475667
126Gingivitis (HP:0000230)1.90858369
127Verrucae (HP:0200043)1.90673287
128Papilloma (HP:0012740)1.90673287
129Abnormal platelet function (HP:0011869)1.90462181
130Impaired platelet aggregation (HP:0003540)1.90462181
131Restrictive lung disease (HP:0002091)1.90442062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.36651767
2KIT3.15483212
3BLK2.95396846
4TYK22.78445845
5TXK2.73213851
6JAK32.65106415
7TGFBR22.53084571
8CSF1R2.51666137
9MAP3K142.37029714
10ZAP702.35730755
11TEC2.28805344
12IRAK42.25725036
13FLT32.21934348
14NME22.19597973
15PRPF4B2.18110651
16MAPK152.10197641
17IKBKE2.06065254
18EEF2K2.03115688
19BTK2.01712404
20* TBK11.94368831
21ERN11.87409841
22SYK1.72594267
23STK101.70732205
24PIM21.68080559
25ITK1.66987459
26CLK11.64543142
27KDR1.63865572
28JAK11.59015965
29IKBKB1.55306493
30TGFBR11.52066419
31MAP3K31.49316569
32RIPK41.45316315
33MAP2K31.43681797
34LCK1.43181658
35TNK21.42880844
36LRRK21.34121995
37RPS6KA41.32109232
38MAP3K111.27580095
39IRAK31.26134496
40FGFR41.24684468
41NLK1.22579846
42HCK1.21656844
43FES1.19217223
44LYN1.17331512
45MAPK71.12626703
46CSK1.10464616
47TESK11.09011456
48MAP3K71.08184030
49GRK61.07487747
50PRKD21.06837562
51PKN21.05304705
52PIM11.01785141
53SMG10.98344459
54PTK2B0.97645556
55MAP3K130.97085764
56MAP3K100.96230205
57MYLK0.95312053
58TAOK20.94016947
59MAP3K60.93578662
60SCYL20.86853942
61FGFR30.86850348
62MATK0.84801677
63ACVR1B0.84467987
64TAOK30.84440150
65MAP3K10.83371507
66NEK90.81879812
67CHUK0.81834554
68EPHB10.78877135
69ADRBK20.78076720
70MAPK120.76606949
71MAP2K20.75183808
72PAK40.75022563
73TESK20.70340835
74MARK20.69873314
75TSSK60.68324010
76TRIB30.67868559
77EIF2AK30.67849518
78JAK20.67794109
79RPS6KB20.67215854
80MST40.64033860
81CAMKK20.63049232
82TAOK10.62565467
83BCKDK0.62411556
84SIK30.61452822
85GRK70.61212967
86TRPM70.59618455
87BMPR20.58569434
88MAPKAPK30.58414167
89EIF2AK10.57834690
90VRK10.57475453
91CDC42BPA0.54255471
92TTN0.52538125
93CDK40.52436220
94PDPK10.52117241
95STK40.51703544
96NEK20.50503058
97MOS0.49704977
98PRKG20.48775685
99MAPKAPK20.46951838
100MAP3K120.46502563
101CDK80.46020645
102DYRK30.45594560
103EPHA30.45060492
104CDK60.44442281
105MAP3K80.43519215
106EIF2AK20.43327261
107RPS6KA20.43240631
108MARK30.42646991
109STK380.42547089
110TIE10.42208624
111PIK3CG0.42097920
112RPS6KA60.41454032
113MAPK40.41002809
114DAPK10.39612049
115MAPK30.39037270
116FYN0.38859777
117ATR0.38364570
118MAPK110.37551252
119PTK60.36908464
120WEE10.36887174
121IRAK10.36411597
122SIK10.35722239
123PRKD10.35465698
124HIPK20.35199856
125SIK20.34913739
126TLK10.32520880
127PRKCD0.31244169
128PRKCQ0.30920061
129STK160.30487137
130ABL10.30355587
131MAP2K60.28946014
132RPS6KC10.28735889
133RPS6KL10.28735889
134BRSK20.28611245
135PDK10.27021054

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.61942823
2Antigen processing and presentation_Homo sapiens_hsa046122.58190228
3Leishmaniasis_Homo sapiens_hsa051402.55632685
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.42554324
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.34441743
6Measles_Homo sapiens_hsa051622.34039100
7DNA replication_Homo sapiens_hsa030302.29633545
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.25296584
9B cell receptor signaling pathway_Homo sapiens_hsa046622.16390413
10Osteoclast differentiation_Homo sapiens_hsa043802.08808956
11* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04236341
12Allograft rejection_Homo sapiens_hsa053302.01171991
13Ribosome_Homo sapiens_hsa030101.96816985
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.90938249
15Hematopoietic cell lineage_Homo sapiens_hsa046401.89718666
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85268886
17Herpes simplex infection_Homo sapiens_hsa051681.80203708
18* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72549630
19Legionellosis_Homo sapiens_hsa051341.67276254
20Other glycan degradation_Homo sapiens_hsa005111.65883465
21Base excision repair_Homo sapiens_hsa034101.62607317
22Graft-versus-host disease_Homo sapiens_hsa053321.62433434
23T cell receptor signaling pathway_Homo sapiens_hsa046601.61767814
24Pertussis_Homo sapiens_hsa051331.60849762
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.59309060
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55879623
27Toxoplasmosis_Homo sapiens_hsa051451.52662502
28Malaria_Homo sapiens_hsa051441.50201114
29Influenza A_Homo sapiens_hsa051641.49461865
30Mismatch repair_Homo sapiens_hsa034301.45878173
31Shigellosis_Homo sapiens_hsa051311.45298799
32Staphylococcus aureus infection_Homo sapiens_hsa051501.41202605
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38633325
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.38134381
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36552997
36Tuberculosis_Homo sapiens_hsa051521.29920403
37Apoptosis_Homo sapiens_hsa042101.29913299
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29774905
39Viral myocarditis_Homo sapiens_hsa054161.29698351
40Hepatitis B_Homo sapiens_hsa051611.28254097
41TNF signaling pathway_Homo sapiens_hsa046681.23668770
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.22699151
43Acute myeloid leukemia_Homo sapiens_hsa052211.17999989
44Non-homologous end-joining_Homo sapiens_hsa034501.11971273
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08382460
46Salmonella infection_Homo sapiens_hsa051321.08251767
47Chemokine signaling pathway_Homo sapiens_hsa040621.08230328
48Homologous recombination_Homo sapiens_hsa034401.04882442
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04559620
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01135881
51Epstein-Barr virus infection_Homo sapiens_hsa051691.01024030
52Autoimmune thyroid disease_Homo sapiens_hsa053201.00452075
53Asthma_Homo sapiens_hsa053100.99479648
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98161500
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95238088
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92217957
57Pancreatic cancer_Homo sapiens_hsa052120.90884174
58Chronic myeloid leukemia_Homo sapiens_hsa052200.90646055
59Lysosome_Homo sapiens_hsa041420.90350938
60Platelet activation_Homo sapiens_hsa046110.89325145
61Proteasome_Homo sapiens_hsa030500.88940106
62HTLV-I infection_Homo sapiens_hsa051660.87500728
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87200666
64Viral carcinogenesis_Homo sapiens_hsa052030.84434117
65Spliceosome_Homo sapiens_hsa030400.84337538
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84160325
67Nucleotide excision repair_Homo sapiens_hsa034200.83195151
68p53 signaling pathway_Homo sapiens_hsa041150.82744026
69Hepatitis C_Homo sapiens_hsa051600.79354254
70African trypanosomiasis_Homo sapiens_hsa051430.75459529
71N-Glycan biosynthesis_Homo sapiens_hsa005100.74304253
72Type I diabetes mellitus_Homo sapiens_hsa049400.72934544
73Small cell lung cancer_Homo sapiens_hsa052220.72366806
74Protein export_Homo sapiens_hsa030600.65270428
75Rheumatoid arthritis_Homo sapiens_hsa053230.64933346
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64598183
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64371066
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.63738186
79Pyrimidine metabolism_Homo sapiens_hsa002400.63523463
80Endocytosis_Homo sapiens_hsa041440.61097562
81Cell cycle_Homo sapiens_hsa041100.58561152
82Colorectal cancer_Homo sapiens_hsa052100.58043664
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.57846883
84Arachidonic acid metabolism_Homo sapiens_hsa005900.54672988
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53435205
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53018380
87Prolactin signaling pathway_Homo sapiens_hsa049170.51090393
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.50770896
89Phagosome_Homo sapiens_hsa041450.49252315
90Systemic lupus erythematosus_Homo sapiens_hsa053220.48342920
91One carbon pool by folate_Homo sapiens_hsa006700.48071414
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47095723
93HIF-1 signaling pathway_Homo sapiens_hsa040660.45334605
94Regulation of autophagy_Homo sapiens_hsa041400.44685517
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44631656
96Notch signaling pathway_Homo sapiens_hsa043300.43204333
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.43173195
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43077750
99Pentose phosphate pathway_Homo sapiens_hsa000300.43023595
100RNA degradation_Homo sapiens_hsa030180.42998615
101Choline metabolism in cancer_Homo sapiens_hsa052310.41822650
102Insulin resistance_Homo sapiens_hsa049310.41219542
103Fanconi anemia pathway_Homo sapiens_hsa034600.39437632
104Caffeine metabolism_Homo sapiens_hsa002320.39194870
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.38312396
106VEGF signaling pathway_Homo sapiens_hsa043700.37937353
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.37636580
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37621158
109Non-small cell lung cancer_Homo sapiens_hsa052230.37046359
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35764714
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35275162
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33118995
113Thyroid cancer_Homo sapiens_hsa052160.32960712
114Focal adhesion_Homo sapiens_hsa045100.32956482
115MAPK signaling pathway_Homo sapiens_hsa040100.32760186
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32039613
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31236221
118Renin-angiotensin system_Homo sapiens_hsa046140.30922654
119GnRH signaling pathway_Homo sapiens_hsa049120.29983094
120Amoebiasis_Homo sapiens_hsa051460.28867963
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28322817
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26606594
123Bladder cancer_Homo sapiens_hsa052190.26012849
124Complement and coagulation cascades_Homo sapiens_hsa046100.25981356
125Chemical carcinogenesis_Homo sapiens_hsa052040.22358395
126Inositol phosphate metabolism_Homo sapiens_hsa005620.20583250
127mTOR signaling pathway_Homo sapiens_hsa041500.19206369

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