TMEM14C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)7.02047779
2protoporphyrinogen IX metabolic process (GO:0046501)6.90727820
3* heme biosynthetic process (GO:0006783)5.77714445
4* heme metabolic process (GO:0042168)5.14650302
5* porphyrin-containing compound biosynthetic process (GO:0006779)4.81969073
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.69217486
7DNA deamination (GO:0045006)4.39958294
8* porphyrin-containing compound metabolic process (GO:0006778)4.31085693
9* tetrapyrrole biosynthetic process (GO:0033014)4.30315768
10ribosomal small subunit assembly (GO:0000028)4.23768982
11establishment of integrated proviral latency (GO:0075713)4.21664291
12regulation of mitochondrial translation (GO:0070129)4.12061705
13proteasome assembly (GO:0043248)3.88726371
14protein complex biogenesis (GO:0070271)3.84021875
15protein neddylation (GO:0045116)3.79783238
16telomere maintenance via semi-conservative replication (GO:0032201)3.78874340
17mitochondrial respiratory chain complex assembly (GO:0033108)3.70319040
18DNA strand elongation involved in DNA replication (GO:0006271)3.70039279
19viral transcription (GO:0019083)3.65420553
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64306609
21establishment of viral latency (GO:0019043)3.58355977
22protein targeting to mitochondrion (GO:0006626)3.57332399
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55627147
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.55627147
25NADH dehydrogenase complex assembly (GO:0010257)3.55627147
26translational termination (GO:0006415)3.55171131
27respiratory chain complex IV assembly (GO:0008535)3.54344026
28cullin deneddylation (GO:0010388)3.51945946
29DNA strand elongation (GO:0022616)3.50498238
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.45449300
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43998598
32cotranslational protein targeting to membrane (GO:0006613)3.40505262
33protein targeting to ER (GO:0045047)3.37514692
34positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35598472
35ATP synthesis coupled proton transport (GO:0015986)3.35253171
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35253171
37protein maturation by protein folding (GO:0022417)3.33111915
38aldehyde catabolic process (GO:0046185)3.32080279
39establishment of protein localization to mitochondrion (GO:0072655)3.30512539
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.29768610
41termination of RNA polymerase III transcription (GO:0006386)3.29768610
42DNA replication initiation (GO:0006270)3.27890579
43ATP biosynthetic process (GO:0006754)3.27724549
44protein localization to mitochondrion (GO:0070585)3.26931432
45protein deneddylation (GO:0000338)3.26526431
46translational elongation (GO:0006414)3.25551094
47protein localization to endoplasmic reticulum (GO:0070972)3.24713823
48signal transduction involved in DNA damage checkpoint (GO:0072422)3.23237888
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.23237888
50telomere maintenance via recombination (GO:0000722)3.22222711
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21650970
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.20060809
53cytochrome complex assembly (GO:0017004)3.19875981
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19503274
55positive regulation of ligase activity (GO:0051351)3.19078382
56ribosomal small subunit biogenesis (GO:0042274)3.18012679
57signal transduction involved in cell cycle checkpoint (GO:0072395)3.17996194
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17341322
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17341322
60folic acid-containing compound biosynthetic process (GO:0009396)3.16766466
61purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.13554324
62lysine catabolic process (GO:0006554)3.13436550
63lysine metabolic process (GO:0006553)3.13436550
64inner mitochondrial membrane organization (GO:0007007)3.12204552
65oxidative phosphorylation (GO:0006119)3.05986298
66cellular component biogenesis (GO:0044085)3.04459349
67regulation of ubiquitin-protein transferase activity (GO:0051438)3.03626500
68DNA replication checkpoint (GO:0000076)3.02512703
69* tetrapyrrole metabolic process (GO:0033013)2.98400726
70purine nucleobase biosynthetic process (GO:0009113)2.98155820
71pteridine-containing compound biosynthetic process (GO:0042559)2.94667922
72mitochondrial transport (GO:0006839)2.93434936
73ribonucleoprotein complex biogenesis (GO:0022613)2.91302343
74ribonucleoside triphosphate biosynthetic process (GO:0009201)2.91296585
75regulation of ligase activity (GO:0051340)2.91070721
76respiratory electron transport chain (GO:0022904)2.90840166
772-deoxyribonucleotide biosynthetic process (GO:0009265)2.90156499
78deoxyribose phosphate biosynthetic process (GO:0046385)2.90156499
79hydrogen ion transmembrane transport (GO:1902600)2.87476706
80protein targeting to membrane (GO:0006612)2.87291723
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87067752
82purine nucleoside monophosphate biosynthetic process (GO:0009127)2.85438001
83purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.85438001
84cofactor catabolic process (GO:0051187)2.85274419
85rRNA modification (GO:0000154)2.84845746
86translational initiation (GO:0006413)2.84610173
87* pigment biosynthetic process (GO:0046148)2.83954886
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83796765
89electron transport chain (GO:0022900)2.83051797
90deoxyribonucleotide biosynthetic process (GO:0009263)2.82096461
91spliceosomal snRNP assembly (GO:0000387)2.81388070
92erythrocyte maturation (GO:0043249)2.81192529
93nucleoside triphosphate biosynthetic process (GO:0009142)2.80772475
94histone exchange (GO:0043486)2.80309429
95mitotic recombination (GO:0006312)2.80131126
96cysteine metabolic process (GO:0006534)2.79152694
97nucleobase-containing small molecule interconversion (GO:0015949)2.79009608
98DNA damage response, detection of DNA damage (GO:0042769)2.78590447
99regulation of cellular amino acid metabolic process (GO:0006521)2.78357523
100translation (GO:0006412)2.78221692
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.78182486
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77909094
103pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77883391
104viral life cycle (GO:0019058)2.77606643
105CENP-A containing nucleosome assembly (GO:0034080)2.77471460
106hydrogen peroxide catabolic process (GO:0042744)2.76129396
107protein autoprocessing (GO:0016540)2.73861239
108chaperone-mediated protein transport (GO:0072321)2.73426104
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72622191
110iron-sulfur cluster assembly (GO:0016226)2.72527511
111metallo-sulfur cluster assembly (GO:0031163)2.72527511
112* pigment metabolic process (GO:0042440)2.71785020
113mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71712250
114L-phenylalanine catabolic process (GO:0006559)2.71415854
115erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.71415854
116ribosomal large subunit biogenesis (GO:0042273)2.71113627
117transcription-coupled nucleotide-excision repair (GO:0006283)2.71092307
118L-phenylalanine metabolic process (GO:0006558)2.70473353
119erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.70473353
120antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.70288289
121heme transport (GO:0015886)2.65910827
122cellular protein complex disassembly (GO:0043624)2.64470754
123pyrimidine nucleotide catabolic process (GO:0006244)2.63442714
124maturation of SSU-rRNA (GO:0030490)2.61794820
125negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.61707889
126chromatin remodeling at centromere (GO:0031055)2.60836940
127signal peptide processing (GO:0006465)2.60015343
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.59632711
129DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.58191208
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57765659
131folic acid metabolic process (GO:0046655)2.57748083
132nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.56390999
133telomere maintenance via telomere lengthening (GO:0010833)2.54502405
134purine-containing compound salvage (GO:0043101)2.54122899
135negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53987062
136negative regulation of ligase activity (GO:0051352)2.53987062
137signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.53431622
138intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.53431622
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.51937280
140regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.51122160
141ethanol oxidation (GO:0006069)2.51028344
142* cofactor biosynthetic process (GO:0051188)2.50633184
143amino acid salvage (GO:0043102)2.49766502
144L-methionine salvage (GO:0071267)2.49766502
145L-methionine biosynthetic process (GO:0071265)2.49766502
146serine family amino acid biosynthetic process (GO:0009070)2.49468686
147signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.48307492
148signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.48307492
149signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.48307492
150formation of translation preinitiation complex (GO:0001731)2.47775006
151aerobic respiration (GO:0009060)2.47325638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.29745239
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.43214065
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.53884993
4* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.37726147
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.24889278
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.11062910
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99262733
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.82354803
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77841135
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66482126
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64603018
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.62942226
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.60254739
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51063862
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.35501975
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22109082
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17119473
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.15897293
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13178082
20* SRF_21415370_ChIP-Seq_HL-1_Mouse2.12362278
21* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11626567
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05868120
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04903567
24DCP1A_22483619_ChIP-Seq_HELA_Human2.02126074
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00019373
26* RXR_22158963_ChIP-Seq_LIVER_Mouse1.98208760
27VDR_23849224_ChIP-Seq_CD4+_Human1.98185557
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97724590
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97555280
30* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.92605037
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.85790941
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85516497
33XRN2_22483619_ChIP-Seq_HELA_Human1.82448803
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78883465
35* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76440368
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76172715
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74811108
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72524320
39GABP_19822575_ChIP-Seq_HepG2_Human1.71982773
40FOXP3_21729870_ChIP-Seq_TREG_Human1.71807779
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70145703
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69810723
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64493688
44GATA1_22025678_ChIP-Seq_K562_Human1.63772173
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62288789
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62169350
47AR_21909140_ChIP-Seq_LNCAP_Human1.57494295
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55113025
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49932153
50* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49109339
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.49100461
52* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48858941
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47994192
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47200734
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44934116
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.35273050
57ELK1_19687146_ChIP-ChIP_HELA_Human1.34449104
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32753539
59TTF2_22483619_ChIP-Seq_HELA_Human1.32511852
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30999324
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.30673154
62* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30238446
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.29688838
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.28703861
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28623775
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28199973
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28120644
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26743083
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26473057
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.26401242
71* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25355507
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24291804
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.23783764
74* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21543823
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20375410
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18689956
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17407265
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.17271523
79LXR_22158963_ChIP-Seq_LIVER_Mouse1.17208063
80ZNF263_19887448_ChIP-Seq_K562_Human1.15896355
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.14892610
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14676154
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13957832
84SPI1_23547873_ChIP-Seq_NB4_Human1.12817528
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11811605
86KDM5A_27292631_Chip-Seq_BREAST_Human1.10807959
87VDR_21846776_ChIP-Seq_THP-1_Human1.09843037
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07973029
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06795545
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06065875
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05681155
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05553321
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04922955
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04382915
95* GATA1_19941827_ChIP-Seq_MEL_Mouse1.02746252
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00868650
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00203846
98* TFEB_21752829_ChIP-Seq_HELA_Human0.98706192
99NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98099094
100SCL_19346495_ChIP-Seq_HPC-7_Human0.97723476
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.96862839
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96758676
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96646548
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95879675
105* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95291480
106STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92528314
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91369272
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90860381
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90407583
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89126531
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88602256
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87936982
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86085639
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86005444
115* MYC_18940864_ChIP-ChIP_HL60_Human0.85558568
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85221590
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85157123
118CIITA_25753668_ChIP-Seq_RAJI_Human0.85028481
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84726319
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83593747
121CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83331206
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83038285
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83002566
124KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82711675
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82486441
126TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81854848
127EOMES_21245162_ChIP-Seq_HESCs_Human0.81259935
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78291983
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77430835
130RBPJ_22232070_ChIP-Seq_NCS_Mouse0.75431168
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75230983
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74845115
133ELF5_23300383_ChIP-Seq_T47D_Human0.74226691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo5.21305707
2MP0004147_increased_porphyrin_level4.96723479
3MP0003806_abnormal_nucleotide_metabolis4.39120426
4MP0002139_abnormal_hepatobiliary_system3.76651377
5MP0005360_urolithiasis3.39050655
6MP0010030_abnormal_orbit_morphology3.23792215
7MP0003186_abnormal_redox_activity2.97707674
8MP0002938_white_spotting2.66805115
9MP0005085_abnormal_gallbladder_physiolo2.60284403
10MP0003693_abnormal_embryo_hatching2.57712948
11MP0000372_irregular_coat_pigmentation2.49815689
12MP0003941_abnormal_skin_development2.49290082
13MP0006036_abnormal_mitochondrial_physio2.47304158
14MP0009840_abnormal_foam_cell2.40371358
15MP0008875_abnormal_xenobiotic_pharmacok2.30932135
16MP0006054_spinal_hemorrhage2.20086568
17MP0005365_abnormal_bile_salt2.11878696
18MP0004957_abnormal_blastocyst_morpholog2.09321891
19MP0003786_premature_aging2.00861368
20MP0010094_abnormal_chromosome_stability1.87496297
21MP0006292_abnormal_olfactory_placode1.84300017
22MP0005083_abnormal_biliary_tract1.76191541
23MP0002132_abnormal_respiratory_system1.75284823
24MP0003718_maternal_effect1.75089248
25MP0003111_abnormal_nucleus_morphology1.69514376
26MP0005636_abnormal_mineral_homeostasis1.68512808
27MP0003077_abnormal_cell_cycle1.64911406
28MP0009333_abnormal_splenocyte_physiolog1.64166800
29MP0005451_abnormal_body_composition1.63732133
30MP0001835_abnormal_antigen_presentation1.63414553
31MP0005397_hematopoietic_system_phenotyp1.62290554
32MP0001545_abnormal_hematopoietic_system1.62290554
33MP0008789_abnormal_olfactory_epithelium1.59149160
34MP0008057_abnormal_DNA_replication1.58278183
35MP0009785_altered_susceptibility_to1.56592433
36MP0001764_abnormal_homeostasis1.56264791
37MP0003724_increased_susceptibility_to1.53811585
38MP0001293_anophthalmia1.50793929
39MP0003191_abnormal_cellular_cholesterol1.49352819
40MP0000490_abnormal_crypts_of1.47708941
41MP0003136_yellow_coat_color1.46843744
42MP0003195_calcinosis1.44117718
43MP0002837_dystrophic_cardiac_calcinosis1.43712959
44MP0006072_abnormal_retinal_apoptosis1.42630425
45MP0003646_muscle_fatigue1.41211946
46MP0005408_hypopigmentation1.39755194
47MP0000609_abnormal_liver_physiology1.39741077
48MP0005332_abnormal_amino_acid1.36595924
49MP0003436_decreased_susceptibility_to1.35806717
50MP0003123_paternal_imprinting1.33078627
51MP0005025_abnormal_response_to1.32224144
52MP0005319_abnormal_enzyme/_coenzyme1.32097331
53MP0010329_abnormal_lipoprotein_level1.31801873
54MP0001853_heart_inflammation1.31765520
55MP0005464_abnormal_platelet_physiology1.31395494
56MP0008469_abnormal_protein_level1.30472100
57MP0002396_abnormal_hematopoietic_system1.29801867
58MP0005584_abnormal_enzyme/coenzyme_acti1.27854060
59MP0002090_abnormal_vision1.25428728
60MP0000685_abnormal_immune_system1.23662202
61MP0003950_abnormal_plasma_membrane1.20889803
62MP0009764_decreased_sensitivity_to1.20101756
63MP0001666_abnormal_nutrient_absorption1.19670980
64MP0009643_abnormal_urine_homeostasis1.18908135
65MP0002419_abnormal_innate_immunity1.16112470
66MP0004272_abnormal_basement_membrane1.15410125
67MP0009697_abnormal_copulation1.15217890
68MP0008438_abnormal_cutaneous_collagen1.14979655
69MP0000689_abnormal_spleen_morphology1.14696363
70MP0005084_abnormal_gallbladder_morpholo1.13855659
71MP0005058_abnormal_lysosome_morphology1.13406119
72MP0005367_renal/urinary_system_phenotyp1.13046306
73MP0000516_abnormal_urinary_system1.13046306
74MP0002148_abnormal_hypersensitivity_rea1.13018066
75MP0005671_abnormal_response_to1.10806267
76MP0002398_abnormal_bone_marrow1.07791670
77MP0006082_CNS_inflammation1.05272433
78MP0006035_abnormal_mitochondrial_morpho1.05007097
79MP0005000_abnormal_immune_tolerance1.03547351
80MP0000598_abnormal_liver_morphology1.03120955
81MP0009763_increased_sensitivity_to1.02724116
82MP0002722_abnormal_immune_system1.01947728
83MP0002429_abnormal_blood_cell1.01666742
84MP0003315_abnormal_perineum_morphology1.00517289
85MP0008058_abnormal_DNA_repair0.99387586
86MP0002295_abnormal_pulmonary_circulatio0.98500034
87MP0005266_abnormal_metabolism0.98408259
88MP0005075_abnormal_melanosome_morpholog0.98129402
89MP0005330_cardiomyopathy0.97673293
90MP0000647_abnormal_sebaceous_gland0.97669287
91MP0001697_abnormal_embryo_size0.96734002
92MP0002102_abnormal_ear_morphology0.96575524
93MP0003937_abnormal_limbs/digits/tail_de0.95104204
94MP0005376_homeostasis/metabolism_phenot0.94489271
95MP0008932_abnormal_embryonic_tissue0.94271761
96MP0001299_abnormal_eye_distance/0.94247664
97MP0003252_abnormal_bile_duct0.94114751
98MP0003011_delayed_dark_adaptation0.93998650
99MP0002233_abnormal_nose_morphology0.93757671
100MP0002210_abnormal_sex_determination0.93462577
101MP0002138_abnormal_hepatobiliary_system0.92763517
102MP0000350_abnormal_cell_proliferation0.92391782
103MP0002118_abnormal_lipid_homeostasis0.91505796
104MP0001542_abnormal_bone_strength0.90789064
105MP0001845_abnormal_inflammatory_respons0.90588224
106MP0005499_abnormal_olfactory_system0.90136081
107MP0005394_taste/olfaction_phenotype0.90136081
108MP0002405_respiratory_system_inflammati0.89972219
109MP0002452_abnormal_antigen_presenting0.89661049
110MP0004782_abnormal_surfactant_physiolog0.89485623
111MP0002723_abnormal_immune_serum0.89364986
112MP0000343_altered_response_to0.88981024
113MP0003567_abnormal_fetal_cardiomyocyte0.88829101
114MP0001800_abnormal_humoral_immune0.88391717
115MP0002019_abnormal_tumor_incidence0.88267946
116MP0001984_abnormal_olfaction0.86564336
117MP0009379_abnormal_foot_pigmentation0.86358523
118MP0008995_early_reproductive_senescence0.86030962
119MP0008877_abnormal_DNA_methylation0.85638319
120MP0005257_abnormal_intraocular_pressure0.84902792
121MP0001529_abnormal_vocalization0.84578436
122MP0002420_abnormal_adaptive_immunity0.84038988
123MP0001819_abnormal_immune_cell0.83539510
124MP0008873_increased_physiological_sensi0.83050623
125MP0004215_abnormal_myocardial_fiber0.82202482
126MP0003121_genomic_imprinting0.81548112
127MP0000716_abnormal_immune_system0.81229378
128MP0001730_embryonic_growth_arrest0.80838268
129MP0005171_absent_coat_pigmentation0.79974124
130MP0001881_abnormal_mammary_gland0.79697408
131MP0008775_abnormal_heart_ventricle0.78125702
132MP0002085_abnormal_embryonic_tissue0.78051774
133MP0000749_muscle_degeneration0.77853962
134MP0004133_heterotaxia0.76985805
135MP0002697_abnormal_eye_size0.76845951
136MP0004019_abnormal_vitamin_homeostasis0.76780393
137MP0001145_abnormal_male_reproductive0.76343692
138MP0002084_abnormal_developmental_patter0.76295545
139MP0001929_abnormal_gametogenesis0.76057222
140MP0004142_abnormal_muscle_tone0.75907495
141MP0000653_abnormal_sex_gland0.75457953
142MP0002080_prenatal_lethality0.75021361
143MP0002234_abnormal_pharynx_morphology0.74992275
144MP0002095_abnormal_skin_pigmentation0.74736005
145MP0000465_gastrointestinal_hemorrhage0.74668302
146MP0003763_abnormal_thymus_physiology0.74518123
147MP0008260_abnormal_autophagy0.74490959
148MP0000358_abnormal_cell_content/0.73415821
149MP0000858_altered_metastatic_potential0.72929875
150MP0000049_abnormal_middle_ear0.72331396
151MP0005197_abnormal_uvea_morphology0.72223196
152MP0000313_abnormal_cell_death0.72061994
153MP0000566_synostosis0.71978943
154MP0001286_abnormal_eye_development0.70426852
155MP0008007_abnormal_cellular_replicative0.69901761
156MP0008872_abnormal_physiological_respon0.69605584
157MP0001672_abnormal_embryogenesis/_devel0.69557228
158MP0005380_embryogenesis_phenotype0.69557228
159MP0001663_abnormal_digestive_system0.69522712
160MP0002111_abnormal_tail_morphology0.68525739
161MP0001790_abnormal_immune_system0.68099191
162MP0005387_immune_system_phenotype0.68099191
163MP0010155_abnormal_intestine_physiology0.67801446
164MP0001727_abnormal_embryo_implantation0.67451293
165MP0002160_abnormal_reproductive_system0.62916051
166MP0001661_extended_life_span0.62415190
167MP0005253_abnormal_eye_physiology0.61726655
168MP0010386_abnormal_urinary_bladder0.60247185
169MP0009672_abnormal_birth_weight0.59918373
170MP0001324_abnormal_eye_pigmentation0.59658637

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)7.74687539
2Abnormal number of erythroid precursors (HP:0012131)4.86076381
3Abnormality of cells of the erythroid lineage (HP:0012130)4.77511036
4Poikilocytosis (HP:0004447)3.98369517
5Hepatic necrosis (HP:0002605)3.67586883
6Acute necrotizing encephalopathy (HP:0006965)3.62761923
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.51836355
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.51836355
9Hyperbilirubinemia (HP:0002904)3.51756032
10Acute encephalopathy (HP:0006846)3.51262543
11Hepatocellular necrosis (HP:0001404)3.50605984
12Abnormal mitochondria in muscle tissue (HP:0008316)3.48391786
13Mitochondrial inheritance (HP:0001427)3.41880685
14Nausea (HP:0002018)3.35256857
15Acanthocytosis (HP:0001927)3.33242699
16Increased serum ferritin (HP:0003281)3.22801300
17Increased CSF lactate (HP:0002490)3.20593916
18Reticulocytosis (HP:0001923)3.11496453
19Lipid accumulation in hepatocytes (HP:0006561)3.09702832
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.02983369
21Cerebral edema (HP:0002181)2.98895848
22Increased hepatocellular lipid droplets (HP:0006565)2.96207645
23Abnormality of iron homeostasis (HP:0011031)2.95436206
24Birth length less than 3rd percentile (HP:0003561)2.94256769
25Abnormality of reticulocytes (HP:0004312)2.93426491
26Increased muscle lipid content (HP:0009058)2.88429562
27Increased intramyocellular lipid droplets (HP:0012240)2.87093400
28Increased serum lactate (HP:0002151)2.84996049
29Diaphragmatic weakness (HP:0009113)2.83627173
30Abnormality of transition element cation homeostasis (HP:0011030)2.80227920
31Cholelithiasis (HP:0001081)2.78942935
32Petechiae (HP:0000967)2.78282640
33Intrahepatic cholestasis (HP:0001406)2.77404357
34Progressive macrocephaly (HP:0004481)2.76337218
35Hypobetalipoproteinemia (HP:0003563)2.75568047
36Ileus (HP:0002595)2.72962320
37Paralysis (HP:0003470)2.72835759
38Abnormality of glycolysis (HP:0004366)2.71960382
39Increased serum pyruvate (HP:0003542)2.71960382
403-Methylglutaconic aciduria (HP:0003535)2.70667202
41Macrocytic anemia (HP:0001972)2.68000883
42Abnormal gallbladder morphology (HP:0012437)2.65916968
43Exertional dyspnea (HP:0002875)2.65291842
44Lactic acidosis (HP:0003128)2.64342399
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62619655
46Reticulocytopenia (HP:0001896)2.61302113
47Microvesicular hepatic steatosis (HP:0001414)2.60599814
48Aplastic anemia (HP:0001915)2.59722671
49Pallor (HP:0000980)2.59177818
50Abnormality of fatty-acid metabolism (HP:0004359)2.59165161
51Abnormality of the anterior horn cell (HP:0006802)2.54200793
52Degeneration of anterior horn cells (HP:0002398)2.54200793
53Hyperglycinemia (HP:0002154)2.54030609
54Renal Fanconi syndrome (HP:0001994)2.53484037
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.52654740
56Generalized aminoaciduria (HP:0002909)2.52335267
57Oral leukoplakia (HP:0002745)2.49225996
58Respiratory failure (HP:0002878)2.47726849
59Dicarboxylic aciduria (HP:0003215)2.47233731
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47233731
61Hyperammonemia (HP:0001987)2.42715180
62Cholecystitis (HP:0001082)2.41096425
63Abnormal gallbladder physiology (HP:0012438)2.41096425
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38426197
65Abnormal protein N-linked glycosylation (HP:0012347)2.38426197
66Abnormal protein glycosylation (HP:0012346)2.38426197
67Abnormal glycosylation (HP:0012345)2.38426197
68Prolonged partial thromboplastin time (HP:0003645)2.37479062
69Lethargy (HP:0001254)2.36691532
70Multiple enchondromatosis (HP:0005701)2.35256479
71Hypoglycemic coma (HP:0001325)2.32449983
72Cutaneous photosensitivity (HP:0000992)2.29592356
73Glycosuria (HP:0003076)2.29103585
74Abnormality of urine glucose concentration (HP:0011016)2.29103585
75Microcytic anemia (HP:0001935)2.26638402
76Abnormality of renal resorption (HP:0011038)2.24779892
77Optic disc pallor (HP:0000543)2.22864185
78Reduced antithrombin III activity (HP:0001976)2.22784632
79Abnormality of serum amino acid levels (HP:0003112)2.22422796
80Hepatocellular carcinoma (HP:0001402)2.22186564
81Abnormality of pyrimidine metabolism (HP:0004353)2.19919830
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.19595206
83Xanthomatosis (HP:0000991)2.19134540
84Abnormality of methionine metabolism (HP:0010901)2.14584186
85Polycythemia (HP:0001901)2.13423322
86Hypochromic microcytic anemia (HP:0004840)2.12128940
87CNS demyelination (HP:0007305)2.11756352
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10481972
89Vomiting (HP:0002013)2.09846631
90Methylmalonic acidemia (HP:0002912)2.09515101
91Deep venous thrombosis (HP:0002625)2.09326545
92Exercise intolerance (HP:0003546)2.08053007
93Respiratory difficulties (HP:0002880)2.06203317
94Colon cancer (HP:0003003)2.05123837
95Recurrent bacterial skin infections (HP:0005406)2.04173358
96Poor head control (HP:0002421)2.03425443
97Recurrent abscess formation (HP:0002722)2.03031260
98Metabolic acidosis (HP:0001942)2.02237295
99Congenital, generalized hypertrichosis (HP:0004540)2.00999735
100Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99633201
101Palpitations (HP:0001962)1.96987716
102Brushfield spots (HP:0001088)1.96105131
103Microretrognathia (HP:0000308)1.96088482
104Methylmalonic aciduria (HP:0012120)1.96020738
105Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93967814
106Emotional lability (HP:0000712)1.93112184
107Recurrent gram-negative bacterial infections (HP:0005420)1.92513299
108Abnormality of the gallbladder (HP:0005264)1.92089860
109Nonimmune hydrops fetalis (HP:0001790)1.90633709
110Sparse eyelashes (HP:0000653)1.90357729
111Leukodystrophy (HP:0002415)1.90307837
112Purpura (HP:0000979)1.89635310
113Cerebral palsy (HP:0100021)1.88818031
114Abnormality of alanine metabolism (HP:0010916)1.88349837
115Hyperalaninemia (HP:0003348)1.88349837
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88349837
117X-linked dominant inheritance (HP:0001423)1.87547592
118Meckel diverticulum (HP:0002245)1.87131345
119Type I transferrin isoform profile (HP:0003642)1.86340446
120Abnormal hemoglobin (HP:0011902)1.86326607
121Secondary amenorrhea (HP:0000869)1.85575948
122Breast hypoplasia (HP:0003187)1.85212708
123Hyperphosphaturia (HP:0003109)1.84033135
124Opisthotonus (HP:0002179)1.82105659
125Gout (HP:0001997)1.80633893
126Abnormality of the labia minora (HP:0012880)1.80140633
127Pancytopenia (HP:0001876)1.79666750
128Hyperglycinuria (HP:0003108)1.76286607
129Hypokinesia (HP:0002375)1.76179868
130Megaloblastic anemia (HP:0001889)1.75934342
131Abnormality of the ileum (HP:0001549)1.73229629
132Testicular atrophy (HP:0000029)1.71408316
133Blindness (HP:0000618)1.71047257
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.69771274
135Medial flaring of the eyebrow (HP:0010747)1.68233801
136Median cleft lip (HP:0000161)1.66928906
137Abnormality of serine family amino acid metabolism (HP:0010894)1.65296724
138Abnormality of glycine metabolism (HP:0010895)1.65296724
139Adrenal hypoplasia (HP:0000835)1.65195734
140Absent thumb (HP:0009777)1.64038825
141Triphalangeal thumb (HP:0001199)1.63161143
142Amniotic constriction ring (HP:0009775)1.61212653
143Abnormality of placental membranes (HP:0011409)1.61212653
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.60990397
145Spastic paraparesis (HP:0002313)1.58935973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.60131316
2VRK24.53160710
3EIF2AK14.14791070
4BUB13.14146650
5BCKDK2.59424157
6PBK2.58179292
7STK162.31676928
8VRK12.26083160
9PIM22.21862544
10EIF2AK32.19246887
11MAP3K122.14348308
12CDC72.10399380
13WEE11.97199747
14TESK21.88717227
15TRIM281.86099905
16MAP4K21.82289816
17ABL21.81729389
18KDR1.80878018
19PLK31.74074969
20ACVR1B1.69966287
21TYK21.66606344
22MST41.66582392
23PDK21.63963249
24ZAK1.63892225
25MAP4K11.58253517
26STK101.57711321
27FLT31.52648162
28TLK11.51534653
29MAP3K111.48913488
30BRSK21.46034657
31NUAK11.42746109
32SCYL21.35348042
33TBK11.34004598
34TAF11.32608136
35BLK1.25854034
36NEK21.23134024
37STK41.23036855
38DYRK31.20615200
39IRAK41.19471513
40ERN11.17646560
41LRRK21.14277773
42MAP3K81.12760139
43AURKA1.11649721
44ERBB41.10655217
45TSSK61.09010794
46AURKB1.08930967
47TAOK31.08258131
48PLK41.08161754
49PIM11.05523474
50CDK81.05135208
51BMPR1B1.04852466
52MAPKAPK51.04705523
53MKNK11.03537116
54WNK31.00949634
55RPS6KA41.00359194
56CSNK1G31.00219589
57BRSK10.99458889
58NEK10.98541021
59KIT0.98023009
60MAP2K30.97445365
61PLK10.95495360
62MAPK110.93957254
63SRPK10.91389488
64TRPM70.91367234
65TTK0.91038859
66IRAK30.90899217
67MAP3K60.90483567
68MST1R0.88875133
69RPS6KB20.88347609
70ARAF0.87745086
71BRAF0.86828976
72IKBKB0.86574791
73ERBB30.85989776
74IKBKE0.85231340
75DAPK30.84940099
76CSNK1G10.82297265
77NME10.81497977
78CSNK1G20.80920686
79TEC0.79730787
80EPHA20.78807646
81EPHB20.78807386
82MAP3K30.78488295
83LYN0.77047157
84DAPK10.76576400
85BTK0.75933175
86JAK20.74075292
87JAK30.73723686
88MAPKAPK30.73471059
89BCR0.73302232
90MAP3K140.70843896
91CDK70.70698160
92EIF2AK20.69931088
93ZAP700.68548056
94MUSK0.68351885
95SYK0.67168283
96CSNK1A1L0.67127356
97PLK20.67027258
98CDK40.66909180
99NEK90.66261899
100PKN20.65591199
101ATR0.64533112
102CSNK2A10.63797682
103MYLK0.62890365
104TESK10.58977730
105GRK60.57939399
106ILK0.57752447
107STK38L0.57214881
108LMTK20.57199701
109STK30.55368573
110CSF1R0.54359517
111MET0.54119148
112MOS0.52392845
113CLK10.51814252
114MKNK20.49947994
115TGFBR10.49543072
116CSNK2A20.48930197
117GRK10.48523534
118MAP3K100.48288640
119PAK10.48144065
120RPS6KA50.46581437
121PHKG20.46560689
122PHKG10.46560689
123DYRK20.45450310
124CDK190.44851165
125CHEK20.43870754
126PASK0.42330702
127TNIK0.42320851
128RAF10.42260378
129LIMK10.41459495
130STK240.40805174
131CCNB10.40542236
132MAP2K70.40138656
133PIK3CG0.40062940
134MAP2K20.39409104
135ATM0.39308155
136MAPKAPK20.38040839
137INSRR0.37133089
138PAK40.36988641
139CDK140.36145850
140MINK10.35491063
141CHEK10.34116691
142CAMK2D0.32870593

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.47926234
2DNA replication_Homo sapiens_hsa030303.33053387
3Ribosome_Homo sapiens_hsa030103.14012950
4Proteasome_Homo sapiens_hsa030502.85360102
5Oxidative phosphorylation_Homo sapiens_hsa001902.23876765
6Mismatch repair_Homo sapiens_hsa034302.19321012
7Parkinsons disease_Homo sapiens_hsa050122.10699781
8Protein export_Homo sapiens_hsa030601.93413237
9RNA polymerase_Homo sapiens_hsa030201.87522914
10Pyrimidine metabolism_Homo sapiens_hsa002401.85954437
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.82526733
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76403547
13Folate biosynthesis_Homo sapiens_hsa007901.76275999
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.75085474
15One carbon pool by folate_Homo sapiens_hsa006701.74699168
16Base excision repair_Homo sapiens_hsa034101.72688343
17Sulfur relay system_Homo sapiens_hsa041221.63657083
18Homologous recombination_Homo sapiens_hsa034401.60079366
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58711701
20Nucleotide excision repair_Homo sapiens_hsa034201.57589095
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55597043
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52503468
23Fatty acid degradation_Homo sapiens_hsa000711.46944064
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.46558687
25Caffeine metabolism_Homo sapiens_hsa002321.46004129
26Peroxisome_Homo sapiens_hsa041461.41316876
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41140932
28Cardiac muscle contraction_Homo sapiens_hsa042601.40139991
29Glutathione metabolism_Homo sapiens_hsa004801.38841821
30Huntingtons disease_Homo sapiens_hsa050161.36941309
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36328157
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34519118
33Vitamin B6 metabolism_Homo sapiens_hsa007501.33508328
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30131411
35Fatty acid elongation_Homo sapiens_hsa000621.25082089
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24729885
37Pyruvate metabolism_Homo sapiens_hsa006201.23678042
38Propanoate metabolism_Homo sapiens_hsa006401.23009015
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22106379
40Alzheimers disease_Homo sapiens_hsa050101.21209984
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20824190
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.20408504
43Pentose phosphate pathway_Homo sapiens_hsa000301.18962489
44Carbon metabolism_Homo sapiens_hsa012001.17475071
45Histidine metabolism_Homo sapiens_hsa003401.14469954
46Selenocompound metabolism_Homo sapiens_hsa004501.14382828
47Chemical carcinogenesis_Homo sapiens_hsa052041.13110639
48Tryptophan metabolism_Homo sapiens_hsa003801.10890555
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10009326
50Spliceosome_Homo sapiens_hsa030401.09193158
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08845720
52Biosynthesis of amino acids_Homo sapiens_hsa012301.04618624
53beta-Alanine metabolism_Homo sapiens_hsa004101.02998744
54Complement and coagulation cascades_Homo sapiens_hsa046100.99665586
55Sulfur metabolism_Homo sapiens_hsa009200.99456198
56Fatty acid metabolism_Homo sapiens_hsa012120.96354120
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93464170
58Steroid biosynthesis_Homo sapiens_hsa001000.92975008
59Cell cycle_Homo sapiens_hsa041100.90193041
60Non-homologous end-joining_Homo sapiens_hsa034500.88043452
61RNA transport_Homo sapiens_hsa030130.87875050
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86751136
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84999837
64Metabolic pathways_Homo sapiens_hsa011000.83454755
65Purine metabolism_Homo sapiens_hsa002300.82190235
66Staphylococcus aureus infection_Homo sapiens_hsa051500.81097541
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80879343
68Arginine and proline metabolism_Homo sapiens_hsa003300.80513242
69RNA degradation_Homo sapiens_hsa030180.77242450
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76420973
71Phenylalanine metabolism_Homo sapiens_hsa003600.76307667
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75961810
73Arginine biosynthesis_Homo sapiens_hsa002200.75287486
74Tyrosine metabolism_Homo sapiens_hsa003500.74221781
75Basal transcription factors_Homo sapiens_hsa030220.72986421
76Retinol metabolism_Homo sapiens_hsa008300.71796653
77Fanconi anemia pathway_Homo sapiens_hsa034600.70794639
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70319121
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.68780158
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66823809
81PPAR signaling pathway_Homo sapiens_hsa033200.64274361
82Systemic lupus erythematosus_Homo sapiens_hsa053220.63974723
83ABC transporters_Homo sapiens_hsa020100.62803463
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60543955
85Fructose and mannose metabolism_Homo sapiens_hsa000510.60188362
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.59212764
87Collecting duct acid secretion_Homo sapiens_hsa049660.58617198
88Linoleic acid metabolism_Homo sapiens_hsa005910.58328076
89Other glycan degradation_Homo sapiens_hsa005110.58130014
90Legionellosis_Homo sapiens_hsa051340.54676977
91Vibrio cholerae infection_Homo sapiens_hsa051100.52084398
92Malaria_Homo sapiens_hsa051440.51978585
93Butanoate metabolism_Homo sapiens_hsa006500.51690011
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50738172
95Starch and sucrose metabolism_Homo sapiens_hsa005000.48581120
96p53 signaling pathway_Homo sapiens_hsa041150.48449789
97Arachidonic acid metabolism_Homo sapiens_hsa005900.46801326
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45951934
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.44782195
100Fat digestion and absorption_Homo sapiens_hsa049750.44282007
101Galactose metabolism_Homo sapiens_hsa000520.42915864
102Oocyte meiosis_Homo sapiens_hsa041140.41700275
103Hematopoietic cell lineage_Homo sapiens_hsa046400.39874165
104Vitamin digestion and absorption_Homo sapiens_hsa049770.36374215
105N-Glycan biosynthesis_Homo sapiens_hsa005100.34562156
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33855053
107Herpes simplex infection_Homo sapiens_hsa051680.33821363
108Nitrogen metabolism_Homo sapiens_hsa009100.33528536
109Antigen processing and presentation_Homo sapiens_hsa046120.31670619
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31268781
111Regulation of autophagy_Homo sapiens_hsa041400.29905514
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28445716
113Mineral absorption_Homo sapiens_hsa049780.26169204
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23740981
115Basal cell carcinoma_Homo sapiens_hsa052170.22528972
116mRNA surveillance pathway_Homo sapiens_hsa030150.21851789

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