TMEM144

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.47362539
2central nervous system myelination (GO:0022010)7.47362539
3synaptic vesicle maturation (GO:0016188)5.95916173
4negative regulation of protein localization to cell surface (GO:2000009)5.84713694
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.77210364
6cellular potassium ion homeostasis (GO:0030007)5.73952252
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.53717577
8glutamate secretion (GO:0014047)5.45424976
9fatty acid elongation (GO:0030497)5.24705181
10creatine metabolic process (GO:0006600)5.02053724
11synaptic vesicle exocytosis (GO:0016079)4.90112278
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.75900790
13sodium ion export (GO:0071436)4.73842326
14neuronal ion channel clustering (GO:0045161)4.61610541
15sarcomere organization (GO:0045214)4.57807243
16potassium ion homeostasis (GO:0055075)4.52368426
17aspartate family amino acid catabolic process (GO:0009068)4.47059890
18presynaptic membrane organization (GO:0097090)4.42786343
19regulation of synaptic vesicle exocytosis (GO:2000300)4.41792062
20cardiac myofibril assembly (GO:0055003)4.40532771
21regulation of short-term neuronal synaptic plasticity (GO:0048172)4.40196282
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.38644261
23neurotransmitter uptake (GO:0001504)4.10413254
24neuronal action potential propagation (GO:0019227)4.07360317
25presynaptic membrane assembly (GO:0097105)4.05421752
26myelin maintenance (GO:0043217)4.04751161
27neurotransmitter secretion (GO:0007269)4.03980291
28regulation of neuronal synaptic plasticity (GO:0048168)4.02004472
29L-amino acid import (GO:0043092)4.01196254
30regulation of synaptic vesicle transport (GO:1902803)3.97756563
31tricarboxylic acid cycle (GO:0006099)3.95496563
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94891381
33regulation of lipoprotein metabolic process (GO:0050746)3.94548659
34negative regulation of potassium ion transmembrane transport (GO:1901380)3.87111426
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.84986214
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83212245
37cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.82457343
38myofibril assembly (GO:0030239)3.80493072
39ensheathment of neurons (GO:0007272)3.75031737
40axon ensheathment (GO:0008366)3.75031737
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.74308025
42locomotory exploration behavior (GO:0035641)3.74109628
43myelination (GO:0042552)3.73574673
44astrocyte development (GO:0014002)3.72900625
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.70216962
46heme transport (GO:0015886)3.67813049
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.67049065
48ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.56620986
49cellular sodium ion homeostasis (GO:0006883)3.55935095
50regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.55101917
51cardiac muscle tissue morphogenesis (GO:0055008)3.54754206
52regulation of actin filament-based movement (GO:1903115)3.54699647
53neurotransmitter transport (GO:0006836)3.54330632
54response to methylmercury (GO:0051597)3.52788326
55cell wall macromolecule catabolic process (GO:0016998)3.52537170
56cell wall macromolecule metabolic process (GO:0044036)3.52537170
57acidic amino acid transport (GO:0015800)3.51025610
58thioester biosynthetic process (GO:0035384)3.50463931
59acyl-CoA biosynthetic process (GO:0071616)3.50463931
60regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50414275
61cerebellar granule cell differentiation (GO:0021707)3.50030037
62neuron cell-cell adhesion (GO:0007158)3.47894885
63fusion of sperm to egg plasma membrane (GO:0007342)3.47232908
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45659741
65adult heart development (GO:0007512)3.43061687
66gamma-aminobutyric acid transport (GO:0015812)3.39117977
67substantia nigra development (GO:0021762)3.38509813
68membrane tubulation (GO:0097320)3.38496864
69heart trabecula formation (GO:0060347)3.38309869
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.36848037
71L-phenylalanine catabolic process (GO:0006559)3.36848037
72synaptic transmission, glutamatergic (GO:0035249)3.36836877
73postsynaptic membrane organization (GO:0001941)3.36721929
74long-term synaptic potentiation (GO:0060291)3.36099016
75glutamate receptor signaling pathway (GO:0007215)3.34717921
76negative regulation of macroautophagy (GO:0016242)3.33326623
77cardiac muscle hypertrophy (GO:0003300)3.31048769
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.30904194
79C4-dicarboxylate transport (GO:0015740)3.29764641
80neuron-neuron synaptic transmission (GO:0007270)3.27564377
81regulation of neurotransmitter levels (GO:0001505)3.26304434
82carnitine transport (GO:0015879)3.25385955
83amino-acid betaine transport (GO:0015838)3.25385955
84cerebellar Purkinje cell differentiation (GO:0021702)3.24607393
85L-phenylalanine metabolic process (GO:0006558)3.24071504
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.24071504
87acrosome reaction (GO:0007340)3.23459478
88negative regulation of dendrite morphogenesis (GO:0050774)3.22761526
89vocalization behavior (GO:0071625)3.22753738
90mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.21327443
91L-glutamate transport (GO:0015813)3.20091584
92dicarboxylic acid catabolic process (GO:0043649)3.19773420
93cardiac muscle cell development (GO:0055013)3.19093998
94regulation of synaptic plasticity (GO:0048167)3.17053249
95sperm motility (GO:0030317)3.16474682
96regulation of cardioblast differentiation (GO:0051890)3.15924936
97positive regulation of synapse maturation (GO:0090129)3.15809309
98carnitine transmembrane transport (GO:1902603)3.14712891
99positive regulation of potassium ion transmembrane transport (GO:1901381)3.12181655
100regulation of neurotransmitter secretion (GO:0046928)3.11947036
101positive regulation of membrane potential (GO:0045838)3.11898831
102regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.11629187
103proline transport (GO:0015824)3.10428831
104ATP synthesis coupled proton transport (GO:0015986)3.10359166
105energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10359166
106transmission of nerve impulse (GO:0019226)3.10165429
107regulation of excitatory postsynaptic membrane potential (GO:0060079)3.09814793
108membrane depolarization during action potential (GO:0086010)3.09674561
109positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.09230719
110striated muscle hypertrophy (GO:0014897)3.09192749
111positive regulation of potassium ion transport (GO:0043268)3.07583287
112fatty-acyl-CoA biosynthetic process (GO:0046949)3.07114561
113gap junction assembly (GO:0016264)3.06648553
114muscle tissue morphogenesis (GO:0060415)3.06530253
115regulation of neurotransmitter transport (GO:0051588)3.06368897
116ventricular cardiac muscle cell action potential (GO:0086005)3.04057354
117detection of calcium ion (GO:0005513)3.03606064
118cell communication by electrical coupling (GO:0010644)3.03224475
119cholesterol biosynthetic process (GO:0006695)3.02155635
120bundle of His cell to Purkinje myocyte communication (GO:0086069)3.01727919
121cardiac muscle contraction (GO:0060048)3.00701595
122regulation of sequestering of triglyceride (GO:0010889)3.00636617
123fatty acid beta-oxidation (GO:0006635)3.00182631
124very long-chain fatty acid metabolic process (GO:0000038)2.99579021
125exploration behavior (GO:0035640)2.98231133
126heart process (GO:0003015)2.98061494
127heart contraction (GO:0060047)2.98061494
128positive regulation of Rap GTPase activity (GO:0032854)2.97856443
129regulation of glutamate receptor signaling pathway (GO:1900449)2.96878973
130neurotransmitter-gated ion channel clustering (GO:0072578)2.96712341
131response to mercury ion (GO:0046689)2.95903262
132regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.95254076
133adult walking behavior (GO:0007628)2.95181933
134astrocyte differentiation (GO:0048708)2.95179495
135regulation of dendritic spine development (GO:0060998)2.94578637
136positive regulation of dendritic spine development (GO:0060999)2.92631760
137regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.92176128
138regulation of voltage-gated calcium channel activity (GO:1901385)2.91232773
139potassium ion import (GO:0010107)2.90904055
140actomyosin structure organization (GO:0031032)2.90675970
141long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.89976864
142amino acid import (GO:0043090)2.89364096
143cardiac cell development (GO:0055006)2.89358724
144sterol biosynthetic process (GO:0016126)2.89308030
145regulation of postsynaptic membrane potential (GO:0060078)2.88616236
146regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.88395336
147phosphorelay signal transduction system (GO:0000160)2.88082103
148multicellular organism reproduction (GO:0032504)2.87124300
149respiratory electron transport chain (GO:0022904)2.86999656
150alpha-linolenic acid metabolic process (GO:0036109)2.85974503
151acetyl-CoA metabolic process (GO:0006084)2.85752929
152neuromuscular process controlling balance (GO:0050885)2.84641438
153fatty-acyl-CoA metabolic process (GO:0035337)2.84083924
154short-chain fatty acid metabolic process (GO:0046459)2.83644481
155amyloid precursor protein metabolic process (GO:0042982)2.82974802
156negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82666064
157carnitine shuttle (GO:0006853)2.82377421
158regulation of Rap GTPase activity (GO:0032317)2.81965298
159neuromuscular process controlling posture (GO:0050884)2.81677159
160serotonin metabolic process (GO:0042428)2.81510181
161quaternary ammonium group transport (GO:0015697)2.81370334
162regulation of cardiac muscle cell contraction (GO:0086004)2.80960137
163long-chain fatty acid biosynthetic process (GO:0042759)2.80406324
164fatty acid catabolic process (GO:0009062)2.80174179
165protein localization to synapse (GO:0035418)2.79899113
166regulation of striated muscle contraction (GO:0006942)2.79883478
167nerve growth factor signaling pathway (GO:0038180)2.79591950
168glyoxylate metabolic process (GO:0046487)2.79062005
169cell communication involved in cardiac conduction (GO:0086065)2.78757529
170one-carbon compound transport (GO:0019755)2.78197502
171sperm capacitation (GO:0048240)2.77661063
172electron transport chain (GO:0022900)2.77445326
173regulation of acyl-CoA biosynthetic process (GO:0050812)2.76725490
174negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.74892158
175thioester metabolic process (GO:0035383)2.74633928
176acyl-CoA metabolic process (GO:0006637)2.74633928
177regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74564779
178membrane depolarization (GO:0051899)2.74034879
179regulation of synaptic transmission (GO:0050804)2.72314205
180regulation of dendritic spine morphogenesis (GO:0061001)2.71809703
181negative regulation of inclusion body assembly (GO:0090084)2.70810620
182L-serine metabolic process (GO:0006563)2.70596121
183membrane assembly (GO:0071709)2.70022938
184synaptic transmission (GO:0007268)2.69947757
185regulation of sarcomere organization (GO:0060297)2.69790772
186import into cell (GO:0098657)2.66745501
187muscle filament sliding (GO:0030049)2.66045562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.72491973
2EZH2_22144423_ChIP-Seq_EOC_Human3.43586451
3GBX2_23144817_ChIP-Seq_PC3_Human3.30031258
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.82893578
5EP300_21415370_ChIP-Seq_HL-1_Mouse2.76066047
6VDR_22108803_ChIP-Seq_LS180_Human2.51873591
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.43680625
8DROSHA_22980978_ChIP-Seq_HELA_Human2.42564498
9REST_21632747_ChIP-Seq_MESCs_Mouse2.40574854
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37066262
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32303982
12PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.31286022
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.31113378
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27766844
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.27339103
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.21857104
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19623577
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.19503777
19* SALL4_18804426_ChIP-ChIP_XEN_Mouse2.16569128
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.15724800
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15218376
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11225850
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10973391
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06025619
25TBX20_22328084_ChIP-Seq_HEART_Mouse2.05675055
26TBX20_22080862_ChIP-Seq_HEART_Mouse2.05675055
27PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03347853
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02010235
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01413496
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98502460
31* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92417048
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.92261336
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.91955464
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88305984
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85758331
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84446950
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83044858
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.80538589
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78853840
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.75967866
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.73469378
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69516772
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.69434004
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68523830
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.64437971
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63736768
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.63319207
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.62020849
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.59650947
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59378416
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57142898
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57142898
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56287968
54P300_19829295_ChIP-Seq_ESCs_Human1.56007070
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53509445
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51020216
57EOMES_21245162_ChIP-Seq_HESCs_Human1.50112944
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49733631
59STAT3_23295773_ChIP-Seq_U87_Human1.48380957
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47644330
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47257987
62ZNF263_19887448_ChIP-Seq_K562_Human1.45473415
63* TCF4_23295773_ChIP-Seq_U87_Human1.43998014
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42633870
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.40510373
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38462322
67AR_21572438_ChIP-Seq_LNCaP_Human1.37763479
68ER_23166858_ChIP-Seq_MCF-7_Human1.36453007
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33601182
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33079103
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.32892589
72* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32337369
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31773336
74TAF15_26573619_Chip-Seq_HEK293_Human1.31012387
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.30742047
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28691630
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28349926
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28349926
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28165351
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27780775
81AHR_22903824_ChIP-Seq_MCF-7_Human1.27165618
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26958779
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.26715463
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.26080662
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25594501
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.24210388
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23939496
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21667679
89* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21473620
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20019551
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19164976
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18008856
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17308571
94FOXA2_19822575_ChIP-Seq_HepG2_Human1.16693489
95SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15792445
96TP53_16413492_ChIP-PET_HCT116_Human1.15555483
97P53_22387025_ChIP-Seq_ESCs_Mouse1.13092514
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12905397
99AR_25329375_ChIP-Seq_VCAP_Human1.12435756
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10683517
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.10599776
102RNF2_27304074_Chip-Seq_NSC_Mouse1.10321631
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10116558
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09335084
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09231294
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08614225
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.07950420
108AR_19668381_ChIP-Seq_PC3_Human1.07047451
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06631341
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06563101
111SMAD4_21741376_ChIP-Seq_HESCs_Human1.06452983
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05726975
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.04819095
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.04693008
115SMAD3_21741376_ChIP-Seq_ESCs_Human1.04535160
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02911179
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02696711
118CBP_21632823_ChIP-Seq_H3396_Human1.02043103
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01800924
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.01755393
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01415148
122FLI1_27457419_Chip-Seq_LIVER_Mouse1.01292890
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99599343
124KDM2B_26808549_Chip-Seq_REH_Human0.98286779
125ZNF274_21170338_ChIP-Seq_K562_Hela0.97912346
126SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97695895
127FOXH1_21741376_ChIP-Seq_ESCs_Human0.97508174
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97394848
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97143375
130SOX2_18555785_Chip-Seq_ESCs_Mouse0.95978085
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95512560
132HTT_18923047_ChIP-ChIP_STHdh_Human0.94987512
133TCF4_22108803_ChIP-Seq_LS180_Human0.94916604
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91668368
135PHF8_20622853_ChIP-Seq_HELA_Human0.90613584
136* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90185363
137NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90176156
138NFYA_21822215_ChIP-Seq_K562_Human0.88991321
139TBL1_22424771_ChIP-Seq_293T_Human0.88231639
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87905044
141NFYB_21822215_ChIP-Seq_K562_Human0.87400780
142GATA1_19941826_ChIP-Seq_K562_Human0.86915202
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86897080
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86783334
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86599362
146SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86324587
147SOX17_20123909_ChIP-Seq_XEN_Mouse0.86061048
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85402618
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.84471166
150CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83669161
151NANOG_19829295_ChIP-Seq_ESCs_Human0.82526001
152SOX2_19829295_ChIP-Seq_ESCs_Human0.82526001
153ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82309382
154* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81030902
155GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80661844
156TP63_23658742_ChIP-Seq_EP156T_Human0.80467866
157SMAD3_21741376_ChIP-Seq_HESCs_Human0.80178357
158GATA1_26923725_Chip-Seq_HPCs_Mouse0.79990231
159CSB_26484114_Chip-Seq_FIBROBLAST_Human0.79776420
160FOXO3_23340844_ChIP-Seq_DLD1_Human0.79468928
161GATA6_21074721_ChIP-Seq_CACO-2_Human0.77451938
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.77424720
163LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.75883923
164JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75868862
165LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75735245
166FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75413611
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.75346589
168CBX2_22325352_ChIP-Seq_293T-Rex_Human0.74895568
169MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74504675
170* SMAD3_21741376_ChIP-Seq_EPCs_Human0.74062909
171GATA4_25053715_ChIP-Seq_YYC3_Human0.73852438
172GF1_26923725_Chip-Seq_HPCs_Mouse0.72697214
173* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72670059
174NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.70897928
175STAT1_17558387_ChIP-Seq_HELA_Human0.70676260
176HNFA_21074721_ChIP-Seq_CACO-2_Human0.70595690
177Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70292854
178E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.70195127
179FLI1_21867929_ChIP-Seq_TH2_Mouse0.70062411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.55936345
2MP0003880_abnormal_central_pattern4.05237682
3MP0002837_dystrophic_cardiac_calcinosis4.00921284
4MP0005410_abnormal_fertilization3.90540789
5MP0004084_abnormal_cardiac_muscle3.87597402
6MP0002064_seizures3.72675197
7MP0003950_abnormal_plasma_membrane3.62381445
8MP0009840_abnormal_foam_cell3.53917232
9MP0001486_abnormal_startle_reflex3.42037512
10MP0004215_abnormal_myocardial_fiber3.36810585
11MP0003635_abnormal_synaptic_transmissio3.33525955
12MP0003646_muscle_fatigue3.27930873
13MP0005423_abnormal_somatic_nervous3.23768135
14MP0004036_abnormal_muscle_relaxation3.18114086
15MP0009745_abnormal_behavioral_response3.05832169
16MP0009046_muscle_twitch3.05059829
17MP0003806_abnormal_nucleotide_metabolis3.04544585
18MP0000920_abnormal_myelination3.01520466
19MP0000751_myopathy2.82789920
20MP0005330_cardiomyopathy2.77274426
21MP0000749_muscle_degeneration2.67820159
22MP0002734_abnormal_mechanical_nocicepti2.64647895
23MP0002063_abnormal_learning/memory/cond2.60341683
24MP0003690_abnormal_glial_cell2.47401517
25MP0008569_lethality_at_weaning2.40840354
26MP0001968_abnormal_touch/_nociception2.38996320
27MP0002972_abnormal_cardiac_muscle2.32750170
28MP0005058_abnormal_lysosome_morphology2.26370668
29MP0001501_abnormal_sleep_pattern2.22875933
30MP0002572_abnormal_emotion/affect_behav2.21130943
31MP0005623_abnormal_meninges_morphology2.16960180
32MP0005646_abnormal_pituitary_gland2.10579427
33MP0003137_abnormal_impulse_conducting2.08978749
34MP0002735_abnormal_chemical_nociception2.05087135
35MP0004043_abnormal_pH_regulation2.03971029
36MP0003195_calcinosis2.02009147
37MP0009780_abnormal_chondrocyte_physiolo2.01637872
38MP0006138_congestive_heart_failure2.00335124
39MP0004484_altered_response_of1.99965510
40MP0001984_abnormal_olfaction1.99558224
41MP0004087_abnormal_muscle_fiber1.99302615
42MP0003879_abnormal_hair_cell1.98376403
43MP0003329_amyloid_beta_deposits1.97917448
44MP0000747_muscle_weakness1.82990725
45MP0001970_abnormal_pain_threshold1.82708848
46MP0005620_abnormal_muscle_contractility1.81922996
47MP0005360_urolithiasis1.79379829
48MP0004130_abnormal_muscle_cell1.76552305
49MP0008775_abnormal_heart_ventricle1.76540080
50MP0005385_cardiovascular_system_phenoty1.75266298
51MP0001544_abnormal_cardiovascular_syste1.75266298
52MP0002067_abnormal_sensory_capabilities1.71824432
53MP0010630_abnormal_cardiac_muscle1.71134506
54MP0002269_muscular_atrophy1.69130558
55MP0002733_abnormal_thermal_nociception1.61585513
56MP0000750_abnormal_muscle_regeneration1.58709926
57MP0005332_abnormal_amino_acid1.58368603
58MP0003787_abnormal_imprinting1.58229709
59MP0004742_abnormal_vestibular_system1.56811319
60MP0006036_abnormal_mitochondrial_physio1.56063576
61MP0002139_abnormal_hepatobiliary_system1.53454664
62MP0005085_abnormal_gallbladder_physiolo1.53046266
63MP0004147_increased_porphyrin_level1.52792308
64MP0005386_behavior/neurological_phenoty1.51501831
65MP0004924_abnormal_behavior1.51501831
66MP0005171_absent_coat_pigmentation1.50014397
67MP0004085_abnormal_heartbeat1.49490562
68MP0002736_abnormal_nociception_after1.49180849
69MP0001440_abnormal_grooming_behavior1.48861366
70MP0005551_abnormal_eye_electrophysiolog1.48704763
71MP0003221_abnormal_cardiomyocyte_apopto1.48575665
72MP0005451_abnormal_body_composition1.45002725
73MP0003634_abnormal_glial_cell1.44317515
74MP0002106_abnormal_muscle_physiology1.42839190
75MP0002557_abnormal_social/conspecific_i1.40482831
76MP0002066_abnormal_motor_capabilities/c1.39878188
77MP0005167_abnormal_blood-brain_barrier1.39081561
78MP0000778_abnormal_nervous_system1.36171264
79MP0010386_abnormal_urinary_bladder1.33691767
80MP0002882_abnormal_neuron_morphology1.29372116
81MP0000569_abnormal_digit_pigmentation1.28888847
82MP0004811_abnormal_neuron_physiology1.26631916
83MP0000604_amyloidosis1.26385757
84MP0001177_atelectasis1.25516599
85MP0005165_increased_susceptibility_to1.24854164
86MP0000955_abnormal_spinal_cord1.23637059
87MP0001502_abnormal_circadian_rhythm1.23031109
88MP0005670_abnormal_white_adipose1.22201729
89MP0005369_muscle_phenotype1.19856573
90MP0003123_paternal_imprinting1.15602924
91MP0001963_abnormal_hearing_physiology1.11670180
92MP0005666_abnormal_adipose_tissue1.11615161
93MP0004272_abnormal_basement_membrane1.11123826
94MP0002127_abnormal_cardiovascular_syste1.10777702
95MP0003075_altered_response_to1.10416855
96MP0002118_abnormal_lipid_homeostasis1.09657989
97MP0003828_pulmonary_edema1.09553508
98MP0008875_abnormal_xenobiotic_pharmacok1.06480856
99MP0004145_abnormal_muscle_electrophysio1.04949334
100MP0001529_abnormal_vocalization1.03239713
101MP0003632_abnormal_nervous_system1.02390708
102MP0003633_abnormal_nervous_system1.00178961
103MP0009384_cardiac_valve_regurgitation0.97779280
104MP0002229_neurodegeneration0.97736646
105MP0000759_abnormal_skeletal_muscle0.97506278
106MP0003283_abnormal_digestive_organ0.96938760
107MP0008260_abnormal_autophagy0.96786725
108MP0004019_abnormal_vitamin_homeostasis0.96472664
109MP0004885_abnormal_endolymph0.96362870
110MP0003631_nervous_system_phenotype0.96169624
111MP0000383_abnormal_hair_follicle0.95215649
112MP0002332_abnormal_exercise_endurance0.95131060
113MP0002295_abnormal_pulmonary_circulatio0.94124668
114MP0008872_abnormal_physiological_respon0.92963057
115MP0005365_abnormal_bile_salt0.92614264
116MP0006035_abnormal_mitochondrial_morpho0.91863955
117MP0005584_abnormal_enzyme/coenzyme_acti0.91733463
118MP0002909_abnormal_adrenal_gland0.88210326
119MP0004233_abnormal_muscle_weight0.87795376
120MP0003698_abnormal_male_reproductive0.87584054
121MP0006276_abnormal_autonomic_nervous0.87286462
122MP0004185_abnormal_adipocyte_glucose0.87228030
123MP0000566_synostosis0.86952724
124MP0010678_abnormal_skin_adnexa0.85099789
125MP0003186_abnormal_redox_activity0.84469234
126MP0005375_adipose_tissue_phenotype0.84296618
127MP0003045_fibrosis0.83866897
128MP0001986_abnormal_taste_sensitivity0.82706721
129MP0001661_extended_life_span0.82105733
130MP0001299_abnormal_eye_distance/0.80884946
131MP0003656_abnormal_erythrocyte_physiolo0.80824109
132MP0002152_abnormal_brain_morphology0.79726053
133MP0002184_abnormal_innervation0.79297390
134MP0008877_abnormal_DNA_methylation0.77715099
135MP0001485_abnormal_pinna_reflex0.77516140
136MP0003567_abnormal_fetal_cardiomyocyte0.76708166
137MP0005083_abnormal_biliary_tract0.76483304
138MP0002876_abnormal_thyroid_physiology0.75827605
139MP0004270_analgesia0.75627993
140MP0002638_abnormal_pupillary_reflex0.74981997
141MP0000230_abnormal_systemic_arterial0.74133522
142MP0001958_emphysema0.73315001
143MP0008874_decreased_physiological_sensi0.73167019
144MP0000647_abnormal_sebaceous_gland0.72754703
145MP0005535_abnormal_body_temperature0.71845535
146MP0003191_abnormal_cellular_cholesterol0.70948864
147MP0002822_catalepsy0.70365465
148MP0000343_altered_response_to0.68823963
149MP0005377_hearing/vestibular/ear_phenot0.67929511
150MP0003878_abnormal_ear_physiology0.67929511
151MP0003718_maternal_effect0.66921268
152MP0002752_abnormal_somatic_nervous0.66038288
153MP0009643_abnormal_urine_homeostasis0.65156079
154MP0004510_myositis0.64944899
155MP0002272_abnormal_nervous_system0.64068898
156MP0001905_abnormal_dopamine_level0.63990631
157MP0004142_abnormal_muscle_tone0.63727651
158MP0001929_abnormal_gametogenesis0.62463041
159MP0010329_abnormal_lipoprotein_level0.62294716
160MP0003183_abnormal_peptide_metabolism0.61266708
161MP0005266_abnormal_metabolism0.61063505
162MP0001765_abnormal_ion_homeostasis0.60916801
163MP0000639_abnormal_adrenal_gland0.59934902
164MP0005253_abnormal_eye_physiology0.58792046
165MP0003172_abnormal_lysosome_physiology0.58153899
166MP0002069_abnormal_eating/drinking_beha0.57104848
167MP0000462_abnormal_digestive_system0.57094507
168MP0001756_abnormal_urination0.57005032
169MP0005166_decreased_susceptibility_to0.55799304
170MP0005379_endocrine/exocrine_gland_phen0.54633075
171MP0006082_CNS_inflammation0.53604481
172MP0002090_abnormal_vision0.53174285
173MP0003122_maternal_imprinting0.50838032
174MP0005645_abnormal_hypothalamus_physiol0.48888619

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.93879325
2Myokymia (HP:0002411)5.56853509
3Action tremor (HP:0002345)5.36649947
4Scanning speech (HP:0002168)5.34874125
5Focal seizures (HP:0007359)4.93509668
6Febrile seizures (HP:0002373)4.65524572
7Muscle fiber splitting (HP:0003555)4.56183980
8Sudden death (HP:0001699)4.47483175
9Atonic seizures (HP:0010819)4.27504377
10Epileptic encephalopathy (HP:0200134)4.23206445
11Diplopia (HP:0000651)4.18442366
12Abnormality of binocular vision (HP:0011514)4.18442366
13Ankle clonus (HP:0011448)4.11055101
14Ventricular tachycardia (HP:0004756)4.08382495
15Neurofibrillary tangles (HP:0002185)4.07242720
16Spastic gait (HP:0002064)3.96726661
17Exercise-induced muscle cramps (HP:0003710)3.85876564
18Dysmetria (HP:0001310)3.77575828
19Hyporeflexia of lower limbs (HP:0002600)3.74625224
20Supranuclear gaze palsy (HP:0000605)3.67464118
21Intention tremor (HP:0002080)3.56380765
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.48858850
23Degeneration of the lateral corticospinal tracts (HP:0002314)3.48858850
24Atrial fibrillation (HP:0005110)3.34979299
25Generalized tonic-clonic seizures (HP:0002069)3.33387447
26Muscle hypertrophy of the lower extremities (HP:0008968)3.31957632
27Mutism (HP:0002300)3.28860975
28Progressive cerebellar ataxia (HP:0002073)3.27671904
29Calf muscle hypertrophy (HP:0008981)3.19686810
30Abnormality of glycolysis (HP:0004366)3.19190518
31Increased serum pyruvate (HP:0003542)3.19190518
32Dialeptic seizures (HP:0011146)3.18045629
33Syncope (HP:0001279)3.16535551
34Right ventricular cardiomyopathy (HP:0011663)3.11279634
35Absence seizures (HP:0002121)3.10707912
36Lower limb muscle weakness (HP:0007340)3.10701492
37Abnormal eating behavior (HP:0100738)3.09979995
38Axonal loss (HP:0003447)3.07943984
39Bundle branch block (HP:0011710)3.07690463
40Postural instability (HP:0002172)3.06667173
41Hyperlipoproteinemia (HP:0010980)2.98195213
42Cerebral inclusion bodies (HP:0100314)2.97990778
43Primary atrial arrhythmia (HP:0001692)2.97463702
44Papilledema (HP:0001085)2.96642321
45Increased circulating renin level (HP:0000848)2.96539280
46Hypoglycemic coma (HP:0001325)2.94769145
47Hemiparesis (HP:0001269)2.91764184
48Lipoatrophy (HP:0100578)2.91593763
49Choreoathetosis (HP:0001266)2.86154646
50Dysdiadochokinesis (HP:0002075)2.85993319
51Spastic tetraparesis (HP:0001285)2.83946391
52Exercise-induced myalgia (HP:0003738)2.79867413
53Supraventricular tachycardia (HP:0004755)2.79488056
54Urinary bladder sphincter dysfunction (HP:0002839)2.78966907
55Dilated cardiomyopathy (HP:0001644)2.76847350
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.76064167
57Dicarboxylic aciduria (HP:0003215)2.75816945
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.75816945
59Supraventricular arrhythmia (HP:0005115)2.75758048
60Urinary urgency (HP:0000012)2.72464729
61Difficulty running (HP:0009046)2.72092460
62Myoglobinuria (HP:0002913)2.67934814
63Morphological abnormality of the pyramidal tract (HP:0002062)2.63758530
64Stridor (HP:0010307)2.61929910
65Alacrima (HP:0000522)2.61293762
66Clumsiness (HP:0002312)2.60836289
67Abnormality of the calf musculature (HP:0001430)2.60248996
68Visual hallucinations (HP:0002367)2.59967345
69Diaphragmatic weakness (HP:0009113)2.59529668
70Abnormality of serine family amino acid metabolism (HP:0010894)2.58989643
71Abnormality of glycine metabolism (HP:0010895)2.58989643
72Abnormality of fatty-acid metabolism (HP:0004359)2.58614897
73Limb dystonia (HP:0002451)2.58346826
74Hyperinsulinemic hypoglycemia (HP:0000825)2.58089911
75Palpitations (HP:0001962)2.57134941
76Hemiplegia (HP:0002301)2.56630193
77Xanthomatosis (HP:0000991)2.56440173
78Impaired vibration sensation in the lower limbs (HP:0002166)2.55223020
79Gaze-evoked nystagmus (HP:0000640)2.52964752
80Asymmetric septal hypertrophy (HP:0001670)2.51599110
81Epileptiform EEG discharges (HP:0011182)2.50407482
82Ventricular arrhythmia (HP:0004308)2.49550208
83Akinesia (HP:0002304)2.49432875
84Truncal ataxia (HP:0002078)2.49307734
85Onion bulb formation (HP:0003383)2.49056452
86Status epilepticus (HP:0002133)2.48835468
87Abnormality of the periventricular white matter (HP:0002518)2.47741656
88Hepatic necrosis (HP:0002605)2.46593622
89Hyperammonemia (HP:0001987)2.46389808
90Acute necrotizing encephalopathy (HP:0006965)2.45923721
91Heart block (HP:0012722)2.45224573
92CNS hypomyelination (HP:0003429)2.44333762
93Acute encephalopathy (HP:0006846)2.43870504
94Metabolic alkalosis (HP:0200114)2.42871578
95Anxiety (HP:0000739)2.42728144
96EMG: myopathic abnormalities (HP:0003458)2.41658833
97Pheochromocytoma (HP:0002666)2.41208773
98Clonus (HP:0002169)2.39316113
99Leukodystrophy (HP:0002415)2.37955671
100Hypoalphalipoproteinemia (HP:0003233)2.35695533
101Atrioventricular block (HP:0001678)2.33662959
102Insidious onset (HP:0003587)2.32275379
103Termporal pattern (HP:0011008)2.32275379
104Torticollis (HP:0000473)2.31182794
105Decreased lacrimation (HP:0000633)2.30507855
106Ketoacidosis (HP:0001993)2.30311345
107Neuroendocrine neoplasm (HP:0100634)2.29914189
108Abnormal atrioventricular conduction (HP:0005150)2.29123837
109Tetraplegia (HP:0002445)2.29055382
110Hyperventilation (HP:0002883)2.28645783
111Cerebral edema (HP:0002181)2.28047681
112Hypoplastic left heart (HP:0004383)2.25408259
113Neuronal loss in central nervous system (HP:0002529)2.24189491
114Ketosis (HP:0001946)2.23648236
115Cerebral hypomyelination (HP:0006808)2.23491148
116Abnormal mitochondria in muscle tissue (HP:0008316)2.22487026
117Methylmalonic aciduria (HP:0012120)2.22437572
118Foot dorsiflexor weakness (HP:0009027)2.20458654
119Inappropriate behavior (HP:0000719)2.19970558
120Cerebral hemorrhage (HP:0001342)2.17045775
121Abnormality of the corticospinal tract (HP:0002492)2.16596436
122Abnormality of aromatic amino acid family metabolism (HP:0004338)2.15951082
123Delusions (HP:0000746)2.15873116
124Disinhibition (HP:0000734)2.15813696
125EEG with generalized epileptiform discharges (HP:0011198)2.14693487
126Segmental peripheral demyelination/remyelination (HP:0003481)2.13652333
127Bradykinesia (HP:0002067)2.12852277
128Respiratory failure (HP:0002878)2.12426153
129Athetosis (HP:0002305)2.11837821
130Prolonged neonatal jaundice (HP:0006579)2.11489153
131Megalencephaly (HP:0001355)2.10870901
132Hepatocellular necrosis (HP:0001404)2.09693866
133Absent speech (HP:0001344)2.09418399
134Dynein arm defect of respiratory motile cilia (HP:0012255)2.09389762
135Absent/shortened dynein arms (HP:0200106)2.09389762
136Abnormality of the foot musculature (HP:0001436)2.09344750
137Confusion (HP:0001289)2.07179443
138Impaired smooth pursuit (HP:0007772)2.06575935
139Ventricular fibrillation (HP:0001663)2.06338982
140Broad-based gait (HP:0002136)2.06338164
141Memory impairment (HP:0002354)2.05307576
142Autoamputation (HP:0001218)2.04683784
143Agnosia (HP:0010524)2.04388402
144Apathy (HP:0000741)2.04258478
145Impaired vibratory sensation (HP:0002495)2.04143819
146Pancreatic islet-cell hyperplasia (HP:0004510)2.04025025
147Hypomagnesemia (HP:0002917)2.03856636
148Aplasia involving bones of the extremities (HP:0009825)2.03850932
149Aplasia involving bones of the upper limbs (HP:0009823)2.03850932
150Aplasia of the phalanges of the hand (HP:0009802)2.03850932
151Rigidity (HP:0002063)2.01959401
152Poor eye contact (HP:0000817)2.00797249
153Hyperglycinuria (HP:0003108)2.00649148
154Paraplegia (HP:0010550)1.99759521
155Ileus (HP:0002595)1.98979764
156Sensory axonal neuropathy (HP:0003390)1.98951198
157Spastic paraplegia (HP:0001258)1.98321479
158Hypoplasia of the iris (HP:0007676)1.97982580
159Rhabdomyolysis (HP:0003201)1.97918828
160Abnormality of ocular smooth pursuit (HP:0000617)1.97910005
161Focal dystonia (HP:0004373)1.96000490
162Progressive macrocephaly (HP:0004481)1.95728429
163Prolonged QT interval (HP:0001657)1.95695730
164Proximal tubulopathy (HP:0000114)1.95127111
165Hypsarrhythmia (HP:0002521)1.94819110
166Depression (HP:0000716)1.94530747
167Generalized aminoaciduria (HP:0002909)1.92502592
168Mitochondrial inheritance (HP:0001427)1.91582172
169Hepatosplenomegaly (HP:0001433)1.90949137
170Parakeratosis (HP:0001036)1.90294134
171Retinal atrophy (HP:0001105)1.89575487
172Methylmalonic acidemia (HP:0002912)1.89376834
173Postural tremor (HP:0002174)1.89351563
174Lethargy (HP:0001254)1.87816790
175Hypokalemic alkalosis (HP:0001949)1.87674327
176Peripheral hypomyelination (HP:0007182)1.87504730
177Gowers sign (HP:0003391)1.87091984
178Obstructive sleep apnea (HP:0002870)1.85736905
179Congenital malformation of the right heart (HP:0011723)1.85379748
180Double outlet right ventricle (HP:0001719)1.85379748
181CNS demyelination (HP:0007305)1.85163510
182Metaphyseal dysplasia (HP:0100255)1.83639505
183Genetic anticipation (HP:0003743)1.82440021
184Diminished motivation (HP:0000745)1.81207947
185Craniofacial dystonia (HP:0012179)1.80491877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.05126562
2PDK34.28696984
3PDK44.28696984
4NTRK34.12854470
5PDK24.01891091
6WNK43.06741768
7DAPK22.99933356
8EPHB12.82626970
9OXSR12.64460394
10MARK12.54149283
11PBK2.48938740
12NTRK22.48227918
13TTN2.47109897
14CASK2.40882445
15FRK2.32000900
16LMTK22.28113408
17PKN12.21168042
18PHKG22.16986892
19PHKG12.16986892
20MINK12.11493425
21MAPKAPK52.03389956
22MUSK2.00580246
23FGFR21.96950142
24MET1.88503558
25OBSCN1.87302554
26PINK11.82608587
27PNCK1.80259926
28PLK21.73624825
29DMPK1.68970273
30PIK3CA1.68577176
31WNK11.65589343
32MAP3K91.64883943
33PRKD31.63686806
34CAMK2D1.63257332
35BCKDK1.61981444
36CAMKK11.54906568
37PRKD11.36600282
38CDK51.36598992
39MYLK1.34136459
40MAPK131.32994182
41SGK21.32417329
42MST41.23384682
43PAK31.23316298
44TESK11.23291153
45GRK71.22026662
46PRKCG1.20903140
47CAMKK21.20784973
48MAP3K121.19595626
49BMPR21.19520893
50RIPK41.19120646
51EPHA21.15893290
52TESK21.13291887
53CAMK11.12866959
54GRK51.09266598
55ROCK21.07709529
56BUB11.05106090
57CAMK2B1.04505332
58PDPK11.01459328
59SGK11.00818662
60DAPK10.98738446
61CAMK2G0.97471958
62PRKCH0.97338511
63SGK30.95635039
64NEK60.95242311
65AKT30.95088974
66SGK4940.94328074
67SGK2230.94328074
68TNIK0.87832287
69PTK2B0.86368991
70ALK0.86245005
71GRK10.85784390
72STK110.85515009
73LIMK10.85373277
74MAPK100.84669304
75BCR0.83274884
76DYRK1A0.82318192
77ACVR1B0.81348243
78TYRO30.80996559
79CAMK2A0.80550586
80MAPK120.80431840
81PDK10.79408917
82MAP3K40.76226753
83LATS20.75569901
84NEK10.69220287
85BMPR1B0.69125894
86ICK0.67803350
87RPS6KA30.67627778
88PRKCE0.67615381
89TNK20.65774501
90PRKG20.63999180
91TRIB30.63991289
92PRKACB0.63535542
93INSRR0.63131353
94STK38L0.61110265
95CDK190.59892370
96PRKCZ0.57988882
97STK40.57075379
98CDK150.55383824
99ABL20.55257673
100ILK0.54326181
101PRKCA0.54242386
102CDK180.53657239
103FYN0.51022538
104CSNK1G20.50683697
105WEE10.50196987
106UHMK10.49549332
107STK380.48677087
108RPS6KA50.47846732
109CDK140.46627252
110ARAF0.46275537
111CDC42BPA0.45318903
112DAPK30.45187000
113NME10.44562328
114KDR0.44411416
115GSK3A0.44174624
116CDK11A0.43956098
117CLK10.43186251
118ADRBK20.42587463
119CSNK1A10.41965163
120KSR20.41742802
121MAP2K20.41688348
122RIPK10.41398884
123PRKCQ0.41092785
124FGR0.40346229
125PRKAA20.40112557
126ERBB20.39909081
127TIE10.39554096
128PRKCB0.39272785
129PAK60.39168410
130MST1R0.38938368
131NTRK10.37933216
132EPHA40.37338969
133MAPK70.36614693
134PRKACA0.36177631
135ZAK0.34985080
136TTK0.34276801
137ROCK10.33201922
138CSNK1A1L0.32112961
139PRKAA10.31847218
140WNK30.30040013
141PRKACG0.29172599
142IRAK20.28113967
143CSNK1D0.26409312
144PRKG10.25868033
145PTK60.25737787
146CAMK1G0.25681765
147CSNK1G30.25605139
148TRPM70.24768298
149STK240.24673296
150MAP3K20.23446462
151IRAK10.22907098
152CSNK1G10.22676892
153PAK10.22309351
154FER0.19799224

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.70970664
2Fatty acid elongation_Homo sapiens_hsa000623.53038163
3Synaptic vesicle cycle_Homo sapiens_hsa047213.19683316
4Nitrogen metabolism_Homo sapiens_hsa009103.13178225
5Propanoate metabolism_Homo sapiens_hsa006403.09239210
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.79945689
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63411715
8Insulin secretion_Homo sapiens_hsa049112.59997040
9GABAergic synapse_Homo sapiens_hsa047272.55027960
10Fatty acid metabolism_Homo sapiens_hsa012122.54954950
11Glutamatergic synapse_Homo sapiens_hsa047242.51831038
12Fatty acid degradation_Homo sapiens_hsa000712.50934341
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50630175
14Circadian entrainment_Homo sapiens_hsa047132.50220147
15Morphine addiction_Homo sapiens_hsa050322.47603186
16Steroid biosynthesis_Homo sapiens_hsa001002.46918916
17Long-term potentiation_Homo sapiens_hsa047202.44005052
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.41731526
19Vitamin B6 metabolism_Homo sapiens_hsa007502.39361209
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37791821
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37192853
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33506067
23Amphetamine addiction_Homo sapiens_hsa050312.30748813
24Sulfur metabolism_Homo sapiens_hsa009202.27144169
25Oxidative phosphorylation_Homo sapiens_hsa001902.17676071
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15042785
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14578340
28Pyruvate metabolism_Homo sapiens_hsa006202.07939922
29Cardiac muscle contraction_Homo sapiens_hsa042602.04277117
30Salivary secretion_Homo sapiens_hsa049701.97481708
31Butanoate metabolism_Homo sapiens_hsa006501.97131696
32Carbon metabolism_Homo sapiens_hsa012001.95626882
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92081006
34Parkinsons disease_Homo sapiens_hsa050121.81444446
35Dopaminergic synapse_Homo sapiens_hsa047281.79771164
36Renin secretion_Homo sapiens_hsa049241.78200521
37Fatty acid biosynthesis_Homo sapiens_hsa000611.69093350
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.62020515
39Cocaine addiction_Homo sapiens_hsa050301.55888707
40Histidine metabolism_Homo sapiens_hsa003401.55620871
41Arginine and proline metabolism_Homo sapiens_hsa003301.53576321
42Pancreatic secretion_Homo sapiens_hsa049721.51813105
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44631121
44Ether lipid metabolism_Homo sapiens_hsa005651.41576986
45PPAR signaling pathway_Homo sapiens_hsa033201.38719729
46Peroxisome_Homo sapiens_hsa041461.38381633
47Taste transduction_Homo sapiens_hsa047421.37803114
48Alzheimers disease_Homo sapiens_hsa050101.37743992
49Calcium signaling pathway_Homo sapiens_hsa040201.33385105
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33113147
51Arginine biosynthesis_Homo sapiens_hsa002201.31006089
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30067268
53Cholinergic synapse_Homo sapiens_hsa047251.26932553
54cAMP signaling pathway_Homo sapiens_hsa040241.26720216
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25142473
56Dilated cardiomyopathy_Homo sapiens_hsa054141.25099037
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22292408
58Serotonergic synapse_Homo sapiens_hsa047261.21694435
59Olfactory transduction_Homo sapiens_hsa047401.20436534
60Vitamin digestion and absorption_Homo sapiens_hsa049771.17722091
61Oxytocin signaling pathway_Homo sapiens_hsa049211.14954220
62Huntingtons disease_Homo sapiens_hsa050161.14256013
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11364641
64Biosynthesis of amino acids_Homo sapiens_hsa012301.10282292
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10142062
66Primary bile acid biosynthesis_Homo sapiens_hsa001201.10136998
67Glutathione metabolism_Homo sapiens_hsa004801.09530522
68Long-term depression_Homo sapiens_hsa047301.07574735
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06883128
70Linoleic acid metabolism_Homo sapiens_hsa005911.03310599
71beta-Alanine metabolism_Homo sapiens_hsa004101.03207502
72Mineral absorption_Homo sapiens_hsa049781.02465495
73Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01827214
74Tryptophan metabolism_Homo sapiens_hsa003801.01389069
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98884635
76Thyroid hormone synthesis_Homo sapiens_hsa049180.97670277
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96664776
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96565422
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93155560
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91810078
81Lysosome_Homo sapiens_hsa041420.89287452
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86646347
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86384235
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.86359180
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86097506
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.84971310
87Fat digestion and absorption_Homo sapiens_hsa049750.82243163
88Caffeine metabolism_Homo sapiens_hsa002320.80789042
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80568426
90Estrogen signaling pathway_Homo sapiens_hsa049150.80094549
91GnRH signaling pathway_Homo sapiens_hsa049120.79679601
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.79416412
93Gap junction_Homo sapiens_hsa045400.77784025
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76029921
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75987962
96Folate biosynthesis_Homo sapiens_hsa007900.75559568
97Phototransduction_Homo sapiens_hsa047440.75026218
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74076927
99Metabolic pathways_Homo sapiens_hsa011000.72690759
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.68651761
101Glycerolipid metabolism_Homo sapiens_hsa005610.67736138
102Bile secretion_Homo sapiens_hsa049760.67681373
103Sphingolipid metabolism_Homo sapiens_hsa006000.67274649
104Chemical carcinogenesis_Homo sapiens_hsa052040.64919557
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63598411
106Dorso-ventral axis formation_Homo sapiens_hsa043200.62603247
107Inositol phosphate metabolism_Homo sapiens_hsa005620.62587071
108Fructose and mannose metabolism_Homo sapiens_hsa000510.61634499
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61416092
110Ras signaling pathway_Homo sapiens_hsa040140.60774116
111Tyrosine metabolism_Homo sapiens_hsa003500.60305435
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60014070
113Starch and sucrose metabolism_Homo sapiens_hsa005000.59571931
114Rap1 signaling pathway_Homo sapiens_hsa040150.59525886
115Phenylalanine metabolism_Homo sapiens_hsa003600.59310187
116Circadian rhythm_Homo sapiens_hsa047100.58969417
117Tight junction_Homo sapiens_hsa045300.58482846
118Type II diabetes mellitus_Homo sapiens_hsa049300.58067531
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54741385
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54656466
121Ovarian steroidogenesis_Homo sapiens_hsa049130.54585607
122Arachidonic acid metabolism_Homo sapiens_hsa005900.54065801
123Pentose phosphate pathway_Homo sapiens_hsa000300.53536594
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.51835399
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49612343
126Oocyte meiosis_Homo sapiens_hsa041140.47840385
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46942859
128ABC transporters_Homo sapiens_hsa020100.45660529
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45420942
130Retinol metabolism_Homo sapiens_hsa008300.44780633
131Collecting duct acid secretion_Homo sapiens_hsa049660.43445890
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41567479
133Melanogenesis_Homo sapiens_hsa049160.41178124
134Glioma_Homo sapiens_hsa052140.40773554
135Prion diseases_Homo sapiens_hsa050200.40243410
136MAPK signaling pathway_Homo sapiens_hsa040100.40068848
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39980552
138Regulation of autophagy_Homo sapiens_hsa041400.38316103
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38201048
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.37850314
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37323797
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.37224715
143Complement and coagulation cascades_Homo sapiens_hsa046100.36757991
144Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34537053
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.33581643
146Renal cell carcinoma_Homo sapiens_hsa052110.31364970
147Choline metabolism in cancer_Homo sapiens_hsa052310.29942455
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.28808723
149Selenocompound metabolism_Homo sapiens_hsa004500.25048684
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24592751
151Endocytosis_Homo sapiens_hsa041440.22904149
152AMPK signaling pathway_Homo sapiens_hsa041520.21023826
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20918670
154Galactose metabolism_Homo sapiens_hsa000520.20882832
155Gastric acid secretion_Homo sapiens_hsa049710.20569375
156Glucagon signaling pathway_Homo sapiens_hsa049220.18938878
157Vibrio cholerae infection_Homo sapiens_hsa051100.18717425
158Vascular smooth muscle contraction_Homo sapiens_hsa042700.18359891
159Renin-angiotensin system_Homo sapiens_hsa046140.18206292
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17829497

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »