TMEM143

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)6.16729540
2sarcomere organization (GO:0045214)5.99829242
3carnitine shuttle (GO:0006853)5.82353110
4myofibril assembly (GO:0030239)5.73752296
5cardiac myofibril assembly (GO:0055003)5.67030851
6creatine metabolic process (GO:0006600)5.60520926
7tricarboxylic acid cycle (GO:0006099)5.49608168
8fatty acid transmembrane transport (GO:1902001)5.31214278
9regulation of skeletal muscle contraction (GO:0014819)5.11873470
10fatty acid beta-oxidation (GO:0006635)5.07612747
11regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.00193374
12actin-myosin filament sliding (GO:0033275)4.89592231
13muscle filament sliding (GO:0030049)4.89592231
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.72730734
15response to muscle activity (GO:0014850)4.62664676
16positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.62400890
17regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.54341726
18regulation of acyl-CoA biosynthetic process (GO:0050812)4.49796522
19branched-chain amino acid catabolic process (GO:0009083)4.49466338
20response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.47828724
21carnitine transmembrane transport (GO:1902603)4.43900697
22regulation of relaxation of muscle (GO:1901077)4.42790972
23biotin metabolic process (GO:0006768)4.36337192
24regulation of sarcomere organization (GO:0060297)4.34232375
25response to inactivity (GO:0014854)4.32773124
26adult heart development (GO:0007512)4.29376452
27fatty acid oxidation (GO:0019395)4.26706622
28cardiac muscle contraction (GO:0060048)4.26343085
29fatty acid catabolic process (GO:0009062)4.25572148
30lipid oxidation (GO:0034440)4.19603794
31carnitine transport (GO:0015879)4.18882072
32amino-acid betaine transport (GO:0015838)4.18882072
33protein complex biogenesis (GO:0070271)4.15276895
34actin-mediated cell contraction (GO:0070252)4.13494502
35NADH metabolic process (GO:0006734)4.13353568
36valine metabolic process (GO:0006573)4.12257824
37bundle of His cell to Purkinje myocyte communication (GO:0086069)4.11739829
38branched-chain amino acid metabolic process (GO:0009081)4.10914434
39regulation of actin filament-based movement (GO:1903115)4.10662300
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.07392674
41mitochondrial respiratory chain complex I assembly (GO:0032981)4.07392674
42NADH dehydrogenase complex assembly (GO:0010257)4.07392674
432-oxoglutarate metabolic process (GO:0006103)4.05478988
44negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.05205669
45skeletal muscle fiber development (GO:0048741)4.03620001
46glycogen catabolic process (GO:0005980)4.03315067
47regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.01630062
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.00388954
49regulation of cofactor metabolic process (GO:0051193)3.95405909
50regulation of coenzyme metabolic process (GO:0051196)3.95405909
51muscle contraction (GO:0006936)3.95170014
52short-chain fatty acid metabolic process (GO:0046459)3.94579950
53mitochondrial respiratory chain complex assembly (GO:0033108)3.92254177
54regulation of cell communication by electrical coupling (GO:0010649)3.89050548
55myotube cell development (GO:0014904)3.87716635
56cardiac muscle cell development (GO:0055013)3.84431796
57heart contraction (GO:0060047)3.84068215
58heart process (GO:0003015)3.84068215
59cardiac muscle tissue morphogenesis (GO:0055008)3.79310682
60regulation of fatty acid oxidation (GO:0046320)3.77941680
61actomyosin structure organization (GO:0031032)3.75409134
62sarcoplasmic reticulum calcium ion transport (GO:0070296)3.72622791
63cytochrome complex assembly (GO:0017004)3.72527926
64striated muscle contraction (GO:0006941)3.70149481
65glycogen biosynthetic process (GO:0005978)3.70043861
66glucan biosynthetic process (GO:0009250)3.70043861
67cardiac muscle hypertrophy (GO:0003300)3.69806372
68muscle fiber development (GO:0048747)3.68770958
69quinone biosynthetic process (GO:1901663)3.68708526
70ubiquinone biosynthetic process (GO:0006744)3.68708526
71ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.68141030
72glucan catabolic process (GO:0009251)3.67136624
73respiratory chain complex IV assembly (GO:0008535)3.64180309
74cardiac cell development (GO:0055006)3.60633362
75monocarboxylic acid catabolic process (GO:0072329)3.56901342
76carnitine metabolic process (GO:0009437)3.56448329
77regulation of striated muscle contraction (GO:0006942)3.56441608
78negative regulation of potassium ion transmembrane transport (GO:1901380)3.55247131
79respiratory electron transport chain (GO:0022904)3.52065176
80behavioral response to nicotine (GO:0035095)3.51702789
81lysine catabolic process (GO:0006554)3.50821170
82lysine metabolic process (GO:0006553)3.50821170
83muscle system process (GO:0003012)3.50184184
84cellular ketone body metabolic process (GO:0046950)3.47930956
85striated muscle hypertrophy (GO:0014897)3.47590415
86acetyl-CoA metabolic process (GO:0006084)3.46170644
87quaternary ammonium group transport (GO:0015697)3.44464146
88cellular polysaccharide catabolic process (GO:0044247)3.41771575
89electron transport chain (GO:0022900)3.39538327
90muscle tissue morphogenesis (GO:0060415)3.38936997
91ventricular cardiac muscle cell action potential (GO:0086005)3.38881300
92regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.38558303
93daunorubicin metabolic process (GO:0044597)3.34403452
94polyketide metabolic process (GO:0030638)3.34403452
95doxorubicin metabolic process (GO:0044598)3.34403452
96positive regulation of fatty acid oxidation (GO:0046321)3.34212693
97negative regulation of cAMP-mediated signaling (GO:0043951)3.33215473
98fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.32542925
99skeletal muscle contraction (GO:0003009)3.28757674
100brown fat cell differentiation (GO:0050873)3.28531168
101muscle hypertrophy (GO:0014896)3.26910145
102glyoxylate metabolic process (GO:0046487)3.20986307
103regulation of triglyceride catabolic process (GO:0010896)3.19667936
104regulation of sulfur metabolic process (GO:0042762)3.18255070
105regulation of glucokinase activity (GO:0033131)3.16919407
106regulation of hexokinase activity (GO:1903299)3.16919407
107plasma membrane repair (GO:0001778)3.15654047
108positive regulation of fatty acid beta-oxidation (GO:0032000)3.14398220
109succinate metabolic process (GO:0006105)3.14067578
110ubiquinone metabolic process (GO:0006743)3.14007759
111negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.13576999
112negative regulation of calcium ion transmembrane transport (GO:1903170)3.13576999
113oxidative phosphorylation (GO:0006119)3.12559083
114energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10898164
115ATP synthesis coupled proton transport (GO:0015986)3.10898164
116pyrimidine ribonucleoside catabolic process (GO:0046133)3.10828673
117positive regulation of lipid storage (GO:0010884)3.10669312
118gluconeogenesis (GO:0006094)3.09138871
119response to caffeine (GO:0031000)3.09099142
120mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08079569
121polysaccharide catabolic process (GO:0000272)3.08042622
122tricarboxylic acid metabolic process (GO:0072350)3.06975920
123adrenergic receptor signaling pathway (GO:0071875)3.06801968
124amino-acid betaine metabolic process (GO:0006577)3.06728124
125oxaloacetate metabolic process (GO:0006107)3.03569142
126regulation of cardiac muscle contraction (GO:0055117)3.03103825
127regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.02545088
128base-excision repair, AP site formation (GO:0006285)3.01846349
129aspartate family amino acid catabolic process (GO:0009068)3.00158897
130ketone body metabolic process (GO:1902224)2.99628724
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98478569
132skeletal muscle adaptation (GO:0043501)2.97883337
133neuronal action potential propagation (GO:0019227)2.97743032
134positive regulation of heart rate (GO:0010460)2.96892804
135striated muscle cell development (GO:0055002)2.96031777
136striated muscle atrophy (GO:0014891)2.91411966
137iron-sulfur cluster assembly (GO:0016226)2.90553497
138metallo-sulfur cluster assembly (GO:0031163)2.90553497
139NAD metabolic process (GO:0019674)2.90311714
140skeletal muscle tissue development (GO:0007519)2.89601598
141AMP metabolic process (GO:0046033)2.89518945
142regulation of ATP catabolic process (GO:1903289)2.88353451
143regulation of ATPase activity (GO:0043462)2.88353451
144actin filament-based movement (GO:0030048)2.86474751
145positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.84525970
146positive regulation of mitochondrial fission (GO:0090141)2.83103092
147water-soluble vitamin biosynthetic process (GO:0042364)2.80396129
148negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.77909529
149muscle organ morphogenesis (GO:0048644)2.76774273
150positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.75025797

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.17175409
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.00273481
3* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.64777500
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.17838966
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00210884
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.93697775
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.91811119
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.80407509
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.64436995
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.63896108
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59205116
12BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.57508688
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.52989908
14ZNF274_21170338_ChIP-Seq_K562_Hela2.52247421
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51985936
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50168316
17EZH2_22144423_ChIP-Seq_EOC_Human2.47702409
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.44935655
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.44644140
20* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.38928851
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.29128205
22* ETS1_20019798_ChIP-Seq_JURKAT_Human2.28811639
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28172656
24PCGF2_27294783_Chip-Seq_NPCs_Mouse2.24517893
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.23031231
26TBX20_22080862_ChIP-Seq_HEART_Mouse2.19300977
27TBX20_22328084_ChIP-Seq_HEART_Mouse2.19300977
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.13756158
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07806525
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07609518
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02401586
32ESR1_20079471_ChIP-ChIP_T-47D_Human2.00266170
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.99880718
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97880180
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.95727312
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.94081955
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.84041469
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.82888116
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.82149268
40* P68_20966046_ChIP-Seq_HELA_Human1.81262300
41BCL6_27268052_Chip-Seq_Bcells_Human1.80943111
42* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.73923179
43* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71850947
44GBX2_23144817_ChIP-Seq_PC3_Human1.70872535
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70704029
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.70375578
47E2F1_20622854_ChIP-Seq_HELA_Human1.68015573
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.66851483
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.66801500
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.62920515
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56802320
52GATA1_22025678_ChIP-Seq_K562_Human1.56355236
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56069098
54* OCT4_20526341_ChIP-Seq_ESCs_Human1.55645491
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.55407411
56* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.54774978
57* NANOG_20526341_ChIP-Seq_ESCs_Human1.53908048
58* GABP_19822575_ChIP-Seq_HepG2_Human1.52099440
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.52011044
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51372878
61CTCF_27219007_Chip-Seq_Bcells_Human1.50715169
62* CTCF_26484167_Chip-Seq_Bcells_Mouse1.50442440
63CIITA_25753668_ChIP-Seq_RAJI_Human1.50213992
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.48697760
65PHF8_20622854_ChIP-Seq_HELA_Human1.48461837
66ERA_21632823_ChIP-Seq_H3396_Human1.47851089
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.47832568
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46380849
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44505676
70SA1_27219007_Chip-Seq_Bcells_Human1.43623976
71CTCF_21964334_Chip-Seq_Bcells_Human1.42760637
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40784180
73P53_21459846_ChIP-Seq_SAOS-2_Human1.40243188
74VDR_23849224_ChIP-Seq_CD4+_Human1.39895355
75FOXP3_21729870_ChIP-Seq_TREG_Human1.39816268
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.38997474
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38264727
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35701300
79* FOXP1_21924763_ChIP-Seq_HESCs_Human1.34859797
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.33940718
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32329335
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29870444
83TP53_22573176_ChIP-Seq_HFKS_Human1.26892070
84RAC3_21632823_ChIP-Seq_H3396_Human1.26869281
85RARB_24833708_ChIP-Seq_LIVER_Mouse1.26570671
86BCOR_27268052_Chip-Seq_Bcells_Human1.26470235
87TAF2_19829295_ChIP-Seq_ESCs_Human1.24681727
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.23589033
89CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23017479
90MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.21343166
91* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21085860
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.19524075
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19292483
94XRN2_22483619_ChIP-Seq_HELA_Human1.18848277
95SPI1_20517297_ChIP-Seq_HL60_Human1.18154916
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16281868
97ZFX_18555785_Chip-Seq_ESCs_Mouse1.16251836
98RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15186007
99P300_27268052_Chip-Seq_Bcells_Human1.13612679
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.12996223
101* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12158170
102CTCF_20526341_ChIP-Seq_ESCs_Human1.12066271
103SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11590092
104MYC_19829295_ChIP-Seq_ESCs_Human1.11325338
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10786486
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09896555
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09005405
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08244317
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.08168419
110RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08150987
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07256668
112RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07012577
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06707933
114STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06668051
115P53_22387025_ChIP-Seq_ESCs_Mouse1.06659132
116ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05711922
117GATA3_21867929_ChIP-Seq_CD8_Mouse1.05644174
118BCAT_22108803_ChIP-Seq_LS180_Human1.04305015
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04018737
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03887918
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03744468
122RARA_24833708_ChIP-Seq_LIVER_Mouse1.03730157
123EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02951501
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02468214
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02309864
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01670897
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01473045
128SOX2_21211035_ChIP-Seq_LN229_Human1.01371154
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00405867
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00139031
131SOX2_18555785_Chip-Seq_ESCs_Mouse1.00100600
132CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99531982
133OCT4_18555785_Chip-Seq_ESCs_Mouse0.99363770
134CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99299329
135CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98688327
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97551769
137PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97085430
138ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96787672
139ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96120206
140KLF4_18555785_Chip-Seq_ESCs_Mouse0.95847231
141CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95825365
142PU1_27457419_Chip-Seq_LIVER_Mouse0.95353381
143NMYC_18555785_Chip-Seq_ESCs_Mouse0.95347165
144TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95211971
145MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94983695
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94940703
147OCT4_19829295_ChIP-Seq_ESCs_Human0.94454244
148NCOR_22424771_ChIP-Seq_293T_Human0.91527378
149P300_18555785_Chip-Seq_ESCs_Mouse0.91508425
150GATA3_21878914_ChIP-Seq_MCF-7_Human0.91336996
151* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91004714
152NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90488470
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90244388
154CTCF_18555785_Chip-Seq_ESCs_Mouse0.88903143
155PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87571150
156* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87135263
157AR_21572438_ChIP-Seq_LNCaP_Human0.86872576
158TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86695341
159BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86159405
160SMAD1_18555785_Chip-Seq_ESCs_Mouse0.86095111
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.85412847
162PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84510227
163NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83915479
164PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82441913
165BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81857998
166UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80550314
167SMAD3_21741376_ChIP-Seq_HESCs_Human0.80546916
168STAT1_17558387_ChIP-Seq_HELA_Human0.80455473
169HTT_18923047_ChIP-ChIP_STHdh_Human0.80147182
170AR_20517297_ChIP-Seq_VCAP_Human0.79808649
171* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.78612292
172NANOG_18555785_Chip-Seq_ESCs_Mouse0.78436202
173KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78103884
174NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77607301
175GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77534474
176SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77020389
177DROSHA_22980978_ChIP-Seq_HELA_Human0.76500993
178RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75970879
179SMAD4_21741376_ChIP-Seq_HESCs_Human0.75871506
180VDR_22108803_ChIP-Seq_LS180_Human0.75789251

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.59808831
2MP0003646_muscle_fatigue6.03592741
3MP0005670_abnormal_white_adipose4.22449778
4MP0000751_myopathy4.07046899
5MP0004215_abnormal_myocardial_fiber3.74719312
6MP0004084_abnormal_cardiac_muscle3.54961573
7MP0000749_muscle_degeneration3.36898411
8MP0005330_cardiomyopathy3.17942830
9MP0004036_abnormal_muscle_relaxation3.01223261
10MP0004130_abnormal_muscle_cell2.90725641
11MP0005666_abnormal_adipose_tissue2.44192081
12MP0003828_pulmonary_edema2.40153882
13MP0002972_abnormal_cardiac_muscle2.39301851
14MP0003137_abnormal_impulse_conducting2.34208974
15MP0004087_abnormal_muscle_fiber2.27169982
16MP0005620_abnormal_muscle_contractility2.18376658
17MP0008775_abnormal_heart_ventricle2.14800913
18MP0006036_abnormal_mitochondrial_physio2.10154743
19MP0001544_abnormal_cardiovascular_syste2.06421371
20MP0005385_cardiovascular_system_phenoty2.06421371
21MP0002106_abnormal_muscle_physiology2.02861058
22MP0004484_altered_response_of1.97727433
23MP0005085_abnormal_gallbladder_physiolo1.95807867
24MP0006138_congestive_heart_failure1.94541072
25MP0000750_abnormal_muscle_regeneration1.92749103
26MP0010630_abnormal_cardiac_muscle1.79619747
27MP0002269_muscular_atrophy1.72657223
28MP0005369_muscle_phenotype1.68185239
29MP0005365_abnormal_bile_salt1.66567939
30MP0002332_abnormal_exercise_endurance1.60860980
31MP0005360_urolithiasis1.60790154
32MP0000759_abnormal_skeletal_muscle1.59245353
33MP0004145_abnormal_muscle_electrophysio1.56426210
34MP0002139_abnormal_hepatobiliary_system1.53973699
35MP0004510_myositis1.44835917
36MP0004085_abnormal_heartbeat1.39448479
37MP0005423_abnormal_somatic_nervous1.39052567
38MP0002971_abnormal_brown_adipose1.38483678
39MP0005375_adipose_tissue_phenotype1.38395095
40MP0003195_calcinosis1.35509538
41MP0000372_irregular_coat_pigmentation1.34623775
42MP0005451_abnormal_body_composition1.33070667
43MP0002127_abnormal_cardiovascular_syste1.32554051
44MP0000013_abnormal_adipose_tissue1.26813609
45MP0009697_abnormal_copulation1.25454654
46MP0000343_altered_response_to1.24201468
47MP0005535_abnormal_body_temperature1.23932027
48MP0005334_abnormal_fat_pad1.23799650
49MP0010329_abnormal_lipoprotein_level1.23468238
50MP0003724_increased_susceptibility_to1.21808296
51MP0005645_abnormal_hypothalamus_physiol1.21396639
52MP0005332_abnormal_amino_acid1.20852781
53MP0003950_abnormal_plasma_membrane1.17526433
54MP0002822_catalepsy1.17473500
55MP0003252_abnormal_bile_duct1.15310827
56MP0000747_muscle_weakness1.15134136
57MP0001529_abnormal_vocalization1.14784098
58MP0001661_extended_life_span1.14659633
59MP0003221_abnormal_cardiomyocyte_apopto1.14542127
60MP0002118_abnormal_lipid_homeostasis1.11567192
61MP0010368_abnormal_lymphatic_system1.09894305
62MP0004185_abnormal_adipocyte_glucose1.07888343
63MP0003941_abnormal_skin_development1.07624838
64MP0000566_synostosis1.07418880
65MP0001986_abnormal_taste_sensitivity1.05066527
66MP0002138_abnormal_hepatobiliary_system1.03464546
67MP0001188_hyperpigmentation1.03013333
68MP0006035_abnormal_mitochondrial_morpho1.02732132
69MP0005319_abnormal_enzyme/_coenzyme0.99865067
70MP0001764_abnormal_homeostasis0.98330828
71MP0002876_abnormal_thyroid_physiology0.96780902
72MP0009115_abnormal_fat_cell0.95167564
73MP0005083_abnormal_biliary_tract0.95081665
74MP0003186_abnormal_redox_activity0.94864781
75MP0004147_increased_porphyrin_level0.92605903
76MP0002078_abnormal_glucose_homeostasis0.92040595
77MP0004142_abnormal_muscle_tone0.90483829
78MP0005266_abnormal_metabolism0.90347527
79MP0000733_abnormal_muscle_development0.90307015
80MP0005165_increased_susceptibility_to0.90208374
81MP0000003_abnormal_adipose_tissue0.89218091
82MP0002638_abnormal_pupillary_reflex0.89164290
83MP0003279_aneurysm0.87454171
84MP0000230_abnormal_systemic_arterial0.86755156
85MP0001502_abnormal_circadian_rhythm0.86129745
86MP0008875_abnormal_xenobiotic_pharmacok0.85601264
87MP0003191_abnormal_cellular_cholesterol0.85533760
88MP0002132_abnormal_respiratory_system0.85458912
89MP0006292_abnormal_olfactory_placode0.84848763
90MP0005171_absent_coat_pigmentation0.84183199
91MP0001984_abnormal_olfaction0.82565295
92MP0004019_abnormal_vitamin_homeostasis0.81793821
93MP0009764_decreased_sensitivity_to0.80834044
94MP0003806_abnormal_nucleotide_metabolis0.78493840
95MP0003136_yellow_coat_color0.77262171
96MP0004133_heterotaxia0.77235045
97MP0008877_abnormal_DNA_methylation0.77119122
98MP0002108_abnormal_muscle_morphology0.76750007
99MP0006276_abnormal_autonomic_nervous0.72909275
100MP0008995_early_reproductive_senescence0.71618604
101MP0004043_abnormal_pH_regulation0.71277050
102MP0005584_abnormal_enzyme/coenzyme_acti0.70016496
103MP0005647_abnormal_sex_gland0.69757956
104MP0000609_abnormal_liver_physiology0.68316862
105MP0005409_darkened_coat_color0.68063472
106MP0008872_abnormal_physiological_respon0.67262892
107MP0002653_abnormal_ependyma_morphology0.66381752
108MP0003011_delayed_dark_adaptation0.66253884
109MP0000266_abnormal_heart_morphology0.65348724
110MP0004924_abnormal_behavior0.62957990
111MP0005386_behavior/neurological_phenoty0.62957990
112MP0002163_abnormal_gland_morphology0.62818851
113MP0005551_abnormal_eye_electrophysiolog0.62060721
114MP0001853_heart_inflammation0.61611319
115MP0003567_abnormal_fetal_cardiomyocyte0.60328312
116MP0002970_abnormal_white_adipose0.60064743
117MP0009643_abnormal_urine_homeostasis0.59236878
118MP0001905_abnormal_dopamine_level0.58258600
119MP0001879_abnormal_lymphatic_vessel0.57084839
120MP0005379_endocrine/exocrine_gland_phen0.56100488
121MP0008058_abnormal_DNA_repair0.55607791
122MP0008789_abnormal_olfactory_epithelium0.55582714
123MP0005646_abnormal_pituitary_gland0.52477039
124MP0009046_muscle_twitch0.52077488
125MP0004742_abnormal_vestibular_system0.50230466
126MP0009763_increased_sensitivity_to0.50207435
127MP0004270_analgesia0.49127798
128MP0005448_abnormal_energy_balance0.47650530
129MP0005452_abnormal_adipose_tissue0.47369457
130MP0005376_homeostasis/metabolism_phenot0.46916967
131MP0003953_abnormal_hormone_level0.44077319
132MP0009745_abnormal_behavioral_response0.43137980
133MP0004233_abnormal_muscle_weight0.42371467
134MP0002234_abnormal_pharynx_morphology0.42191085
135MP0002067_abnormal_sensory_capabilities0.41218397
136MP0005253_abnormal_eye_physiology0.41173453

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.59082300
2Nemaline bodies (HP:0003798)8.42955049
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.21480013
4Type 1 muscle fiber predominance (HP:0003803)5.88263870
5Sudden death (HP:0001699)5.58042124
6Ventricular tachycardia (HP:0004756)5.33945208
7Myopathic facies (HP:0002058)5.18668820
8Calf muscle hypertrophy (HP:0008981)5.10741638
9Myoglobinuria (HP:0002913)4.89521907
10Exercise-induced myalgia (HP:0003738)4.85160634
11Muscle hypertrophy of the lower extremities (HP:0008968)4.77457929
12Atrial fibrillation (HP:0005110)4.64174767
13Distal arthrogryposis (HP:0005684)4.52206540
14Lipoatrophy (HP:0100578)4.27310007
15Primary atrial arrhythmia (HP:0001692)4.24248408
16Muscle fiber splitting (HP:0003555)4.23341935
17Supraventricular tachycardia (HP:0004755)4.06968548
18Exercise-induced muscle cramps (HP:0003710)4.06309820
19Abnormality of the calf musculature (HP:0001430)3.98545845
20Rhabdomyolysis (HP:0003201)3.96154027
21Supraventricular arrhythmia (HP:0005115)3.94854961
22Palpitations (HP:0001962)3.94501698
23Hyperglycinuria (HP:0003108)3.93360872
24Hypoglycemic coma (HP:0001325)3.85985839
25Dilated cardiomyopathy (HP:0001644)3.85560263
26Rimmed vacuoles (HP:0003805)3.83111418
27Hepatic necrosis (HP:0002605)3.79467508
28Abnormality of fatty-acid metabolism (HP:0004359)3.77728388
29Abnormality of the left ventricular outflow tract (HP:0011103)3.75614962
30Subaortic stenosis (HP:0001682)3.75614962
31Abnormality of dicarboxylic acid metabolism (HP:0010995)3.72542663
32Dicarboxylic aciduria (HP:0003215)3.72542663
33Round ear (HP:0100830)3.68287587
34Ulnar deviation of the wrist (HP:0003049)3.51124512
35Renal cortical cysts (HP:0000803)3.47068638
36Distal lower limb muscle weakness (HP:0009053)3.46105988
37Ketoacidosis (HP:0001993)3.40537698
38Right ventricular cardiomyopathy (HP:0011663)3.36323516
39Centrally nucleated skeletal muscle fibers (HP:0003687)3.33512575
40Generalized aminoaciduria (HP:0002909)3.29705498
41Increased muscle lipid content (HP:0009058)3.23004308
42Syncope (HP:0001279)3.21378223
43Hyporeflexia of lower limbs (HP:0002600)3.11570781
44EMG: myopathic abnormalities (HP:0003458)3.10086519
45Prolonged QT interval (HP:0001657)3.09333267
46Hepatocellular necrosis (HP:0001404)3.08389889
47Abnormality of serine family amino acid metabolism (HP:0010894)3.07737018
48Abnormality of glycine metabolism (HP:0010895)3.07737018
49Ketosis (HP:0001946)3.04193032
50Heart block (HP:0012722)3.03893527
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.03813989
52Abnormality of alanine metabolism (HP:0010916)3.03813989
53Hyperalaninemia (HP:0003348)3.03813989
54Cerebral edema (HP:0002181)3.01209851
55Acute necrotizing encephalopathy (HP:0006965)2.99576750
56Bundle branch block (HP:0011710)2.99305642
57Abnormal mitochondria in muscle tissue (HP:0008316)2.94956887
58Acute encephalopathy (HP:0006846)2.91665267
59Absent phalangeal crease (HP:0006109)2.90831006
60Asymmetric septal hypertrophy (HP:0001670)2.89358592
61Increased connective tissue (HP:0009025)2.87887631
62Abnormality of skeletal muscle fiber size (HP:0012084)2.87675406
63Abnormal atrioventricular conduction (HP:0005150)2.87074173
64Testicular atrophy (HP:0000029)2.84968228
65Atrioventricular block (HP:0001678)2.84498882
66Lactic acidosis (HP:0003128)2.79883650
67EMG: neuropathic changes (HP:0003445)2.74902795
68Proximal tubulopathy (HP:0000114)2.73082754
69Mitochondrial inheritance (HP:0001427)2.72758850
70Hyperammonemia (HP:0001987)2.69559483
71Increased CSF lactate (HP:0002490)2.68283261
72Increased intramyocellular lipid droplets (HP:0012240)2.64434198
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.61153709
74Calcaneovalgus deformity (HP:0001848)2.59181745
75Ventricular arrhythmia (HP:0004308)2.57165293
76Frequent falls (HP:0002359)2.54592685
77Myotonia (HP:0002486)2.53161965
78Progressive muscle weakness (HP:0003323)2.52576676
79Deformed tarsal bones (HP:0008119)2.47977070
80Exercise intolerance (HP:0003546)2.47210104
81Hyperinsulinemic hypoglycemia (HP:0000825)2.44756418
82Ragged-red muscle fibers (HP:0003200)2.44729739
83Lipid accumulation in hepatocytes (HP:0006561)2.43905659
84Nausea (HP:0002018)2.43883094
85Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39474399
86Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39474399
87Progressive macrocephaly (HP:0004481)2.38872236
88Malignant hyperthermia (HP:0002047)2.38479445
89Insulin-resistant diabetes mellitus (HP:0000831)2.37659217
90Abnormal finger flexion creases (HP:0006143)2.34821958
91Muscle stiffness (HP:0003552)2.30665587
92Hyperglycinemia (HP:0002154)2.29197914
93Lethargy (HP:0001254)2.25885112
94Bulbar palsy (HP:0001283)2.25396775
95Metabolic acidosis (HP:0001942)2.23187278
96Abnormal EKG (HP:0003115)2.22672652
97Left ventricular hypertrophy (HP:0001712)2.22535953
98Difficulty running (HP:0009046)2.21928309
99Increased variability in muscle fiber diameter (HP:0003557)2.20561717
100Weak cry (HP:0001612)2.14192425
101Abnormality of serum amino acid levels (HP:0003112)2.10022686
102Respiratory failure (HP:0002878)2.07621763
103Fetal akinesia sequence (HP:0001989)2.06390589
104Type 2 muscle fiber atrophy (HP:0003554)2.05791172
105Oligomenorrhea (HP:0000876)2.04946304
106Abnormality of urine glucose concentration (HP:0011016)2.04509063
107Glycosuria (HP:0003076)2.04509063
108Limb-girdle muscle atrophy (HP:0003797)2.01588723
109Increased serum lactate (HP:0002151)2.00720021
110Hypoalphalipoproteinemia (HP:0003233)1.99976047
111Palmoplantar keratoderma (HP:0000982)1.97578684
112Distal lower limb amyotrophy (HP:0008944)1.97274951
113Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96103826
114Muscle fiber atrophy (HP:0100295)1.95840225
115Increased hepatocellular lipid droplets (HP:0006565)1.95423138
116Cerebral palsy (HP:0100021)1.94779288
117Vomiting (HP:0002013)1.94171823
118Hyperglycemia (HP:0003074)1.93031566
119Gowers sign (HP:0003391)1.92840996
120Hypoglycemic seizures (HP:0002173)1.92123891
121Neoplasm of the adrenal gland (HP:0100631)1.87886206
122Generalized muscle weakness (HP:0003324)1.87671466
123Facial diplegia (HP:0001349)1.85579084
124Areflexia of lower limbs (HP:0002522)1.85413569
125Abnormality of the renal cortex (HP:0011035)1.83509223
126Methylmalonic aciduria (HP:0012120)1.82037923
127Toxemia of pregnancy (HP:0100603)1.80547368
128Microvesicular hepatic steatosis (HP:0001414)1.78514092
129Neck muscle weakness (HP:0000467)1.78209919
130Duplicated collecting system (HP:0000081)1.78137881
131Fatigable weakness (HP:0003473)1.77465983
132Abnormality of the neuromuscular junction (HP:0003398)1.77465983
133Methylmalonic acidemia (HP:0002912)1.76532621
134Hyperkalemia (HP:0002153)1.66530374
135Waddling gait (HP:0002515)1.65744360
136Muscular dystrophy (HP:0003560)1.62093197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.78995050
2TTN3.69229512
3ZAK3.32487306
4INSRR3.30905240
5OBSCN3.21370073
6PHKG23.01700645
7PHKG13.01700645
8PINK13.00613418
9IRAK32.76750418
10MYLK2.69240816
11LMTK22.57337950
12TIE12.53608951
13PDK42.31048239
14PDK32.31048239
15MUSK2.27627222
16VRK22.14656365
17STK38L2.11479536
18GRK72.02859028
19PIK3CA1.91144538
20STK241.77964830
21TAOK31.76170906
22DMPK1.72161246
23NME11.65710917
24MAPKAPK31.62720338
25PDK21.59802073
26ADRBK21.48808511
27MAP4K11.31280847
28PKN11.31103167
29EIF2AK21.27944743
30STK161.27697394
31PRKAA21.27355870
32BMPR1B1.21576440
33FRK1.20874451
34MAP3K111.20110373
35MAP4K21.17115283
36STK41.13891374
37MAP2K41.12688693
38TXK1.12427889
39IRAK41.10767546
40CAMK1D1.07639017
41MAP3K141.02015434
42SGK20.99748836
43NEK10.99546487
44PRKAA10.95917814
45LIMK10.95775482
46PRPF4B0.94918861
47FLT30.93684973
48DAPK20.92436520
49MAPK120.86487327
50MAPK130.86379163
51CCNB10.84964578
52SIK10.84719251
53CASK0.83336736
54GRK10.82633452
55EPHA30.80651406
56CAMK2D0.79613524
57AKT30.78977035
58MARK10.77124886
59PKN20.76613004
60BMPR20.75764000
61SGK30.74967028
62TNIK0.72757179
63NLK0.72031841
64TRPM70.70403669
65PRKCE0.70097342
66EPHA20.69106170
67PRKD10.68939896
68PIK3CG0.68777351
69TAOK20.67853758
70WNK30.67489161
71CAMK40.66037108
72TEC0.65651960
73TLK10.65007851
74MAP2K70.63234110
75NEK20.63225634
76CDC42BPA0.62967411
77MAP3K70.62921166
78DYRK1B0.62240114
79EEF2K0.60229828
80MAP2K30.59555077
81RPS6KL10.58143330
82RPS6KC10.58143330
83MAP3K50.55500435
84CAMK1G0.54572884
85RPS6KA60.54534089
86TNK20.53608928
87MAP2K60.52563762
88MAPK70.51887002
89IRAK10.51333467
90TGFBR20.50756213
91IKBKE0.49986038
92DYRK20.48125180
93CAMK10.48062452
94SGK2230.47933975
95SGK4940.47933975
96PRKACA0.47691275
97MAPK110.46692141
98JAK10.46586335
99LATS10.46128099
100JAK30.44641708
101PRKACG0.44407160
102SRPK10.44112944
103VRK10.43108198
104KDR0.41426543
105SIK20.41191222
106NUAK10.40691881
107NEK90.40163809
108DYRK30.40003230
109WNK40.39510985
110IKBKB0.39472673
111CAMKK20.39418119
112MAPKAPK50.38626308
113IRAK20.38494514
114CDK80.38360655
115CDK190.38211984
116MAPK40.38094342
117FGFR40.37498693
118STK110.37246205
119SYK0.36296511
120TBK10.35135037
121SGK10.34622737
122PRKCQ0.34147589
123ROCK10.34049525
124STK380.34033140
125CAMK2A0.33958003
126YES10.32969066
127OXSR10.32439845
128ADRBK10.32379891
129ERBB30.32089253
130MAP3K130.31825988
131ERN10.31675547
132MAP3K60.31652949
133KIT0.30412633
134PRKG20.30389136
135CSNK1G30.30219434
136PRKG10.30110386
137CAMK2G0.29865121
138PAK30.29738082
139ATR0.29568830
140AKT20.29564729
141PRKACB0.28228843
142NEK60.28207066
143AURKA0.24067611
144MAP3K40.23905857
145ABL20.23428416
146MAPK150.23217563
147RPS6KA10.21987037
148TESK20.20212903
149RPS6KA50.19847579
150MAP2K10.18757167
151CAMK2B0.18705123
152RPS6KA30.16367887

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.58486832
2Propanoate metabolism_Homo sapiens_hsa006404.33395342
3Fatty acid degradation_Homo sapiens_hsa000713.78270894
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.56986087
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.54368146
6Fatty acid metabolism_Homo sapiens_hsa012123.00419103
7Sulfur relay system_Homo sapiens_hsa041222.64808631
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.53550058
9Oxidative phosphorylation_Homo sapiens_hsa001902.46470852
10Cardiac muscle contraction_Homo sapiens_hsa042602.26575342
11beta-Alanine metabolism_Homo sapiens_hsa004102.22246810
12PPAR signaling pathway_Homo sapiens_hsa033202.22018061
13Parkinsons disease_Homo sapiens_hsa050122.20885905
14Tryptophan metabolism_Homo sapiens_hsa003802.20157771
15Carbon metabolism_Homo sapiens_hsa012002.16115274
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.10670907
17Fatty acid elongation_Homo sapiens_hsa000622.10209628
18Peroxisome_Homo sapiens_hsa041462.00548987
19Butanoate metabolism_Homo sapiens_hsa006501.98744040
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.95503794
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93021085
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90075708
23Dilated cardiomyopathy_Homo sapiens_hsa054141.86714204
24Pyruvate metabolism_Homo sapiens_hsa006201.84042796
25Starch and sucrose metabolism_Homo sapiens_hsa005001.73180655
26Alzheimers disease_Homo sapiens_hsa050101.63069275
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62600526
28Huntingtons disease_Homo sapiens_hsa050161.42452188
29Fatty acid biosynthesis_Homo sapiens_hsa000611.39554719
30Phenylalanine metabolism_Homo sapiens_hsa003601.38378737
31Base excision repair_Homo sapiens_hsa034101.31977592
32Phototransduction_Homo sapiens_hsa047441.29619734
33RNA polymerase_Homo sapiens_hsa030201.29057811
34Lysine degradation_Homo sapiens_hsa003101.23772216
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.22648648
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21781924
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17312790
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17291098
39Arginine and proline metabolism_Homo sapiens_hsa003301.10079188
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07758024
41Arginine biosynthesis_Homo sapiens_hsa002201.07591079
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.07325200
43Nitrogen metabolism_Homo sapiens_hsa009101.03848597
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03158021
45Tyrosine metabolism_Homo sapiens_hsa003501.02533197
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00529194
47ABC transporters_Homo sapiens_hsa020100.99948437
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97584718
49Ribosome_Homo sapiens_hsa030100.93067631
50Homologous recombination_Homo sapiens_hsa034400.87974854
51Purine metabolism_Homo sapiens_hsa002300.85674461
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85094177
53Viral myocarditis_Homo sapiens_hsa054160.82615258
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79026403
55Selenocompound metabolism_Homo sapiens_hsa004500.78042941
56Regulation of autophagy_Homo sapiens_hsa041400.77862066
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75557779
58Biosynthesis of amino acids_Homo sapiens_hsa012300.75206927
59Primary immunodeficiency_Homo sapiens_hsa053400.73576945
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.73302852
61RNA degradation_Homo sapiens_hsa030180.73070218
62Pyrimidine metabolism_Homo sapiens_hsa002400.72527441
63Metabolic pathways_Homo sapiens_hsa011000.71310094
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71172557
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66854540
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66597172
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.65795909
68Oxytocin signaling pathway_Homo sapiens_hsa049210.65413366
69Insulin resistance_Homo sapiens_hsa049310.64935182
70Chemical carcinogenesis_Homo sapiens_hsa052040.64663607
71Histidine metabolism_Homo sapiens_hsa003400.63190420
72Retinol metabolism_Homo sapiens_hsa008300.62393618
73Galactose metabolism_Homo sapiens_hsa000520.62081652
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61736146
75Glycerolipid metabolism_Homo sapiens_hsa005610.61377626
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60789631
77Vitamin digestion and absorption_Homo sapiens_hsa049770.59903833
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59692409
79Staphylococcus aureus infection_Homo sapiens_hsa051500.58762174
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58685992
81Arachidonic acid metabolism_Homo sapiens_hsa005900.57546773
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56241019
83Caffeine metabolism_Homo sapiens_hsa002320.55197066
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55033920
85Glucagon signaling pathway_Homo sapiens_hsa049220.54620999
86One carbon pool by folate_Homo sapiens_hsa006700.54467356
87Basal transcription factors_Homo sapiens_hsa030220.54363144
88Fructose and mannose metabolism_Homo sapiens_hsa000510.52140990
89Complement and coagulation cascades_Homo sapiens_hsa046100.51730739
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51471132
91Insulin signaling pathway_Homo sapiens_hsa049100.46416249
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.45596236
93Fat digestion and absorption_Homo sapiens_hsa049750.43592647
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41340170
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.40444978
96AMPK signaling pathway_Homo sapiens_hsa041520.40398591
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39202955
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38840922
99Other glycan degradation_Homo sapiens_hsa005110.35211667
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.32322792
101Calcium signaling pathway_Homo sapiens_hsa040200.31661581
102Nucleotide excision repair_Homo sapiens_hsa034200.30627749
103Olfactory transduction_Homo sapiens_hsa047400.30317910
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29688145
105Circadian rhythm_Homo sapiens_hsa047100.28215056
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.27782026
107Ovarian steroidogenesis_Homo sapiens_hsa049130.27557045
108Insulin secretion_Homo sapiens_hsa049110.27289170
109DNA replication_Homo sapiens_hsa030300.26010345
110Proteasome_Homo sapiens_hsa030500.25524268
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25125699
112Linoleic acid metabolism_Homo sapiens_hsa005910.23236916
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.22202268
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22119682
115Taste transduction_Homo sapiens_hsa047420.20752711
116Sulfur metabolism_Homo sapiens_hsa009200.20111372
117Pentose phosphate pathway_Homo sapiens_hsa000300.19786007
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18809537
119Graft-versus-host disease_Homo sapiens_hsa053320.18465714
120Fanconi anemia pathway_Homo sapiens_hsa034600.16866907
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.14963966
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14729131
123Folate biosynthesis_Homo sapiens_hsa007900.13681041
124Bile secretion_Homo sapiens_hsa049760.13614767
125Autoimmune thyroid disease_Homo sapiens_hsa053200.13067216
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.12826322
127Glutathione metabolism_Homo sapiens_hsa004800.12392049
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.10825533

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