TMEM141

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.96035939
2central nervous system myelination (GO:0022010)8.96035939
3fatty acid elongation (GO:0030497)8.06396998
4myelination (GO:0042552)7.07460205
5axon ensheathment (GO:0008366)7.06577486
6ensheathment of neurons (GO:0007272)7.06577486
7virion attachment to host cell (GO:0019062)5.69412058
8adhesion of symbiont to host cell (GO:0044650)5.69412058
9cholesterol biosynthetic process (GO:0006695)5.42199671
10long-chain fatty acid biosynthetic process (GO:0042759)5.37918026
11glycerophospholipid catabolic process (GO:0046475)5.23893153
12negative regulation of neurotransmitter secretion (GO:0046929)5.23560309
13GDP-mannose metabolic process (GO:0019673)5.13893824
14substantia nigra development (GO:0021762)5.10748077
15oligodendrocyte differentiation (GO:0048709)4.86673481
16peptidyl-tyrosine autophosphorylation (GO:0038083)4.80877755
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.72461280
18L-phenylalanine metabolic process (GO:0006558)4.72461280
19sterol biosynthetic process (GO:0016126)4.67819025
20protein maturation by protein folding (GO:0022417)4.62401414
21positive regulation of action potential (GO:0045760)4.55775395
22adhesion of symbiont to host (GO:0044406)4.40832391
23creatine metabolic process (GO:0006600)4.40074471
24Golgi transport vesicle coating (GO:0048200)4.28334993
25COPI coating of Golgi vesicle (GO:0048205)4.28334993
26cellular response to hepatocyte growth factor stimulus (GO:0035729)4.28069709
27response to hepatocyte growth factor (GO:0035728)4.28069709
28presynaptic membrane assembly (GO:0097105)4.24832847
29proline biosynthetic process (GO:0006561)4.19967694
30transmission of nerve impulse (GO:0019226)4.18084236
31response to redox state (GO:0051775)4.15091379
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.13985680
33cellular response to epinephrine stimulus (GO:0071872)4.11460289
34negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.09090029
35long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.09033948
36astrocyte development (GO:0014002)4.03698057
37regulation of collateral sprouting (GO:0048670)4.02867191
38NADH metabolic process (GO:0006734)3.93279205
39neurotransmitter catabolic process (GO:0042135)3.86814451
40desmosome organization (GO:0002934)3.85783313
41isoprenoid biosynthetic process (GO:0008299)3.83025297
42peripheral nervous system axon ensheathment (GO:0032292)3.82314908
43myelination in peripheral nervous system (GO:0022011)3.82314908
44presynaptic membrane organization (GO:0097090)3.80499215
45regulation of mitochondrial translation (GO:0070129)3.78969341
46negative regulation of neurotransmitter transport (GO:0051589)3.77118623
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.74880906
48L-phenylalanine catabolic process (GO:0006559)3.74880906
49photoreceptor cell differentiation (GO:0046530)3.73493403
50eye photoreceptor cell differentiation (GO:0001754)3.73493403
51amyloid precursor protein metabolic process (GO:0042982)3.70949200
52regulation of cholesterol esterification (GO:0010872)3.68589362
53fatty-acyl-CoA biosynthetic process (GO:0046949)3.65957127
54negative regulation of axonogenesis (GO:0050771)3.63351149
55long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.61684788
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.59811248
57ear development (GO:0043583)3.59093474
58regulation of memory T cell differentiation (GO:0043380)3.58215648
59response to epinephrine (GO:0071871)3.57882036
60proline metabolic process (GO:0006560)3.54505058
61negative regulation of protein localization to cell surface (GO:2000009)3.47360965
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.46091989
63asymmetric protein localization (GO:0008105)3.45161142
64positive regulation of interleukin-17 production (GO:0032740)3.41877682
65leukocyte migration involved in inflammatory response (GO:0002523)3.41505261
66myelin maintenance (GO:0043217)3.40718075
67nucleotide transmembrane transport (GO:1901679)3.39850726
68fatty-acyl-CoA metabolic process (GO:0035337)3.37209154
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35641697
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.33550117
71ATP synthesis coupled proton transport (GO:0015986)3.33550117
72neural nucleus development (GO:0048857)3.32020360
73Rap protein signal transduction (GO:0032486)3.31291300
74nucleoside diphosphate biosynthetic process (GO:0009133)3.28958984
75negative regulation of axon extension (GO:0030517)3.28141122
76apical protein localization (GO:0045176)3.27800469
77negative regulation of JUN kinase activity (GO:0043508)3.27200134
78peripheral nervous system development (GO:0007422)3.24299112
79protein retention in ER lumen (GO:0006621)3.23996115
80membrane assembly (GO:0071709)3.23629698
81neuronal ion channel clustering (GO:0045161)3.23203174
82chaperone-mediated protein transport (GO:0072321)3.23202411
83L-serine transport (GO:0015825)3.21053070
84oxidative phosphorylation (GO:0006119)3.18777104
85cerebral cortex radially oriented cell migration (GO:0021799)3.18407769
86very-low-density lipoprotein particle assembly (GO:0034379)3.17679168
87magnesium ion transport (GO:0015693)3.17497092
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16531647
89amyloid precursor protein catabolic process (GO:0042987)3.16225869
90response to lipoprotein particle (GO:0055094)3.14258703
91nucleobase-containing small molecule interconversion (GO:0015949)3.12462338
92ribosomal small subunit biogenesis (GO:0042274)3.11205415
93regulation of cell communication by electrical coupling (GO:0010649)3.09769807
94acyl-CoA biosynthetic process (GO:0071616)3.07797930
95thioester biosynthetic process (GO:0035384)3.07797930
96glutamine family amino acid biosynthetic process (GO:0009084)3.05669279
97establishment of mitochondrion localization (GO:0051654)3.04574759
98glutathione biosynthetic process (GO:0006750)3.03651295
99very long-chain fatty acid metabolic process (GO:0000038)3.03283541
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.02630841
101glycosylceramide metabolic process (GO:0006677)3.02546040
102import into cell (GO:0098657)3.01140977
103sulfur amino acid catabolic process (GO:0000098)3.00518179
104protein palmitoylation (GO:0018345)2.99382114
105positive regulation of actin filament depolymerization (GO:0030836)2.96196220
106oxaloacetate metabolic process (GO:0006107)2.94410034
107ribosomal small subunit assembly (GO:0000028)2.92117115
108nucleotide-sugar biosynthetic process (GO:0009226)2.92023105
109plasma lipoprotein particle assembly (GO:0034377)2.89904934
110regulation of activation of Janus kinase activity (GO:0010533)2.89688394
1114-hydroxyproline metabolic process (GO:0019471)2.88522568
112regulation of metalloenzyme activity (GO:0048552)2.86984749
113Golgi to plasma membrane protein transport (GO:0043001)2.86108554
114pentose metabolic process (GO:0019321)2.86032595
115positive regulation of cell fate commitment (GO:0010455)2.85842360
116interleukin-6-mediated signaling pathway (GO:0070102)2.84982560
117cytochrome complex assembly (GO:0017004)2.84504823
118regulation of cholesterol homeostasis (GO:2000188)2.84251806
119membrane tubulation (GO:0097320)2.83600553
120phosphatidylinositol 3-kinase signaling (GO:0014065)2.82898799
121adult walking behavior (GO:0007628)2.82704116
122L-amino acid import (GO:0043092)2.82344681
123GPI anchor biosynthetic process (GO:0006506)2.82004077
124tricarboxylic acid cycle (GO:0006099)2.81989565
125urea cycle (GO:0000050)2.81573834
126fructose metabolic process (GO:0006000)2.81037173
127respiratory electron transport chain (GO:0022904)2.80549212
128GPI anchor metabolic process (GO:0006505)2.80362191
129purine ribonucleotide transport (GO:0015868)2.79658905
130positive regulation of cellular amine metabolic process (GO:0033240)2.78825315
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78519552
132SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.78287138
133retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77545323
134peptidyl-cysteine modification (GO:0018198)2.77507680
135limb bud formation (GO:0060174)2.77295222
136bundle of His cell to Purkinje myocyte communication (GO:0086069)2.77022501
137protein targeting to ER (GO:0045047)2.76931088
138nonribosomal peptide biosynthetic process (GO:0019184)2.76434776
139protein localization to endoplasmic reticulum (GO:0070972)2.75717529
140viral transcription (GO:0019083)2.75584950
141positive regulation of oligodendrocyte differentiation (GO:0048714)2.75063366
142guanosine-containing compound biosynthetic process (GO:1901070)2.74008144
143glial cell development (GO:0021782)2.72369525
144electron transport chain (GO:0022900)2.71153666
145galactose catabolic process (GO:0019388)2.71094043
146serine transport (GO:0032329)2.71041530
147cotranslational protein targeting to membrane (GO:0006613)2.70594294
148Leydig cell differentiation (GO:0033327)2.70524067
149purine nucleotide transport (GO:0015865)2.70303246
150cellular response to catecholamine stimulus (GO:0071870)2.69511287
151GTP biosynthetic process (GO:0006183)2.65545784
152hydrogen peroxide catabolic process (GO:0042744)2.65396005
153glutathione metabolic process (GO:0006749)2.64616485
154protein targeting to mitochondrion (GO:0006626)2.63856287
155monosaccharide biosynthetic process (GO:0046364)2.63832397
156branched-chain amino acid catabolic process (GO:0009083)2.63300746
157establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63116002
158urea metabolic process (GO:0019627)2.62664918
159negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.62137416
160glucose catabolic process (GO:0006007)2.61784746
161respiratory chain complex IV assembly (GO:0008535)2.61266541
162NADP metabolic process (GO:0006739)2.59445334
163gluconeogenesis (GO:0006094)2.58360031
164hexose biosynthetic process (GO:0019319)2.56962371
165daunorubicin metabolic process (GO:0044597)2.56459257
166polyketide metabolic process (GO:0030638)2.56459257
167doxorubicin metabolic process (GO:0044598)2.56459257
168nitrogen cycle metabolic process (GO:0071941)2.55014333
169protein-lipid complex assembly (GO:0065005)2.54809570
170regulation of translational fidelity (GO:0006450)2.53871211
171L-ascorbic acid metabolic process (GO:0019852)2.53182113
172translational termination (GO:0006415)2.52910711
173UTP biosynthetic process (GO:0006228)2.52201994
174glutathione derivative metabolic process (GO:1901685)2.52034037
175glutathione derivative biosynthetic process (GO:1901687)2.52034037
176protein complex biogenesis (GO:0070271)2.49129502
177peroxisome fission (GO:0016559)2.48987738
178pteridine-containing compound biosynthetic process (GO:0042559)2.48508494
179phospholipid efflux (GO:0033700)2.48424612
180regulation of cholesterol metabolic process (GO:0090181)2.48395251
181translational elongation (GO:0006414)2.47933712
182high-density lipoprotein particle remodeling (GO:0034375)2.44630531
183regulation of cholesterol biosynthetic process (GO:0045540)2.44607855
184base-excision repair, AP site formation (GO:0006285)2.43964593
185establishment of protein localization to mitochondrion (GO:0072655)2.43941522
186regulation of cellular amino acid metabolic process (GO:0006521)2.43572335
187proteasome assembly (GO:0043248)2.41075406
188endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.40162963
189UTP metabolic process (GO:0046051)2.40082920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.33694983
2GBX2_23144817_ChIP-Seq_PC3_Human3.45330875
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.26723638
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.23660409
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05940937
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04848189
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97827807
8SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.82180750
9TAF15_26573619_Chip-Seq_HEK293_Human2.80291657
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57879763
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57473234
12ZNF263_19887448_ChIP-Seq_K562_Human2.41873469
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35068027
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.33574032
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.22944556
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20729675
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19315627
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17471612
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.11067038
20VDR_22108803_ChIP-Seq_LS180_Human2.10248550
21RXR_22158963_ChIP-Seq_LIVER_Mouse2.05431898
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03374008
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03361463
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00355958
25ER_23166858_ChIP-Seq_MCF-7_Human1.99440356
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.98214072
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92648354
28* LXR_22292898_ChIP-Seq_THP-1_Human1.92156264
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90048961
30RACK7_27058665_Chip-Seq_MCF-7_Human1.88588536
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85670002
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84163558
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.83827345
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.83754156
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83424937
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79358362
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.77756696
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.76860173
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76818117
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76818117
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75735535
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74986627
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74450104
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.73684356
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72890037
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71618165
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.71237927
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70649942
49DROSHA_22980978_ChIP-Seq_HELA_Human1.68716586
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68429335
51XRN2_22483619_ChIP-Seq_HELA_Human1.68165394
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68133325
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67461024
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67314966
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65940051
56DCP1A_22483619_ChIP-Seq_HELA_Human1.64577440
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61273611
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61005514
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60978262
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60480805
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59816669
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.59812299
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.59446721
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59412322
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58845201
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58473211
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58399286
68* GABP_19822575_ChIP-Seq_HepG2_Human1.56952225
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56385711
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55947197
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55890156
72AR_21572438_ChIP-Seq_LNCaP_Human1.55794384
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54665915
74FUS_26573619_Chip-Seq_HEK293_Human1.54609955
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.54337616
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.50871195
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50333071
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50331658
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.49725179
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47740652
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46707192
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46083089
83CDX2_20551321_ChIP-Seq_CACO-2_Human1.45359612
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45120361
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41416107
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41055729
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39548714
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.39276898
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37808111
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37501127
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36565293
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.35920968
93HTT_18923047_ChIP-ChIP_STHdh_Human1.35648698
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35592708
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35523724
96CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33727201
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.32701948
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31568229
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31542855
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.30107069
101P68_20966046_ChIP-Seq_HELA_Human1.30091770
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29542736
103* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29383122
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.28787615
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27272963
106ATF3_27146783_Chip-Seq_COLON_Human1.27047819
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26187702
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26074741
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25954411
110SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.25953347
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25577936
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24202133
113ELK3_25401928_ChIP-Seq_HUVEC_Human1.23463655
114AR_21909140_ChIP-Seq_LNCAP_Human1.22181665
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21426793
116EOMES_21245162_ChIP-Seq_HESCs_Human1.21408862
117NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20446850
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20446850
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19790390
120VDR_21846776_ChIP-Seq_THP-1_Human1.19222344
121YY1_21170310_ChIP-Seq_MESCs_Mouse1.19036197
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18678691
123ELF1_20517297_ChIP-Seq_JURKAT_Human1.18371001
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17774441
125EST1_17652178_ChIP-ChIP_JURKAT_Human1.16090806
126* GATA6_25053715_ChIP-Seq_YYC3_Human1.15866871
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15848577
128* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15005060
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14443085
130TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14241711
131EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13593128
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13329416
133EP300_21415370_ChIP-Seq_HL-1_Mouse1.12352669
134TRIM28_21343339_ChIP-Seq_HEK293_Human1.11912810
135* BCOR_27268052_Chip-Seq_Bcells_Human1.11811761
136P300_19829295_ChIP-Seq_ESCs_Human1.11698311
137SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11319955
138* FOXP1_21924763_ChIP-Seq_HESCs_Human1.10981653
139REST_21632747_ChIP-Seq_MESCs_Mouse1.10845576
140NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10652481
141* BCL6_27268052_Chip-Seq_Bcells_Human1.10544556
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10431980
143P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10344598
144RNF2_27304074_Chip-Seq_NSC_Mouse1.09955238
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09226436
146RARB_27405468_Chip-Seq_BRAIN_Mouse1.07803802
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07685062
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07405472
149CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06788096
150* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.06593681
151KDM5A_27292631_Chip-Seq_BREAST_Human1.06083917
152* CTCF_26484167_Chip-Seq_Bcells_Mouse1.05112443
153FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04929144
154RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04912596
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03823918
156LXR_22158963_ChIP-Seq_LIVER_Mouse1.03332241
157OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02879550
158SA1_27219007_Chip-Seq_ERYTHROID_Human1.01533778
159REST_18959480_ChIP-ChIP_MESCs_Mouse1.01202124
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01076169
161SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00933042
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00820260
163TTF2_22483619_ChIP-Seq_HELA_Human0.99974090
164TAL1_26923725_Chip-Seq_HPCs_Mouse0.99618303
165TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99476993
166KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99182754
167IRF1_19129219_ChIP-ChIP_H3396_Human0.98812887
168PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98646365
169YY1_22570637_ChIP-Seq_MALME-3M_Human0.98570708
170ZNF274_21170338_ChIP-Seq_K562_Hela0.95256031
171MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94543366
172CMYC_18555785_Chip-Seq_ESCs_Mouse0.94393198
173AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93895876
174SOX9_26525672_Chip-Seq_HEART_Mouse0.93890007
175PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92281968
176NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91647300
177SOX17_20123909_ChIP-Seq_XEN_Mouse0.91365455
178NANOG_18555785_Chip-Seq_ESCs_Mouse0.88714025
179FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88389044
180CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88037060
181STAT3_23295773_ChIP-Seq_U87_Human0.85538569
182CTCF_20526341_ChIP-Seq_ESCs_Human0.85107165
183UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84834208
184TCF4_23295773_ChIP-Seq_U87_Human0.84770492
185P300_18555785_Chip-Seq_ESCs_Mouse0.84124034
186CBP_21632823_ChIP-Seq_H3396_Human0.83290608
187KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82547352
188TBL1_22424771_ChIP-Seq_293T_Human0.82465422
189JUN_21703547_ChIP-Seq_K562_Human0.82418895
190ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81400049
191LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80625840
192GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79981324
193NCOR_22424771_ChIP-Seq_293T_Human0.79532981
194MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79365169
195PHF8_20622853_ChIP-Seq_HELA_Human0.79102984
196STAT1_20625510_ChIP-Seq_HELA_Human0.78459757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.58898595
2MP0010234_abnormal_vibrissa_follicle5.43609738
3MP0002139_abnormal_hepatobiliary_system5.06792951
4MP0003880_abnormal_central_pattern4.28613708
5MP0003690_abnormal_glial_cell3.60466785
6MP0005360_urolithiasis3.47182015
7MP0004270_analgesia3.40859943
8MP0003950_abnormal_plasma_membrane3.20988123
9MP0009840_abnormal_foam_cell3.11728072
10MP0005451_abnormal_body_composition3.00560633
11MP0005365_abnormal_bile_salt2.87535094
12MP0004264_abnormal_extraembryonic_tissu2.84998484
13MP0001905_abnormal_dopamine_level2.79747149
14MP0003329_amyloid_beta_deposits2.79250261
15MP0001529_abnormal_vocalization2.60928888
16MP0001485_abnormal_pinna_reflex2.54427127
17MP0001666_abnormal_nutrient_absorption2.51733690
18MP0003634_abnormal_glial_cell2.48068573
19MP0004742_abnormal_vestibular_system2.47589702
20MP0004885_abnormal_endolymph2.36632694
21MP0003123_paternal_imprinting2.33140041
22MP0002272_abnormal_nervous_system2.31293545
23MP0004147_increased_porphyrin_level2.27590050
24MP0001486_abnormal_startle_reflex2.17649081
25MP0005085_abnormal_gallbladder_physiolo2.15317127
26MP0004019_abnormal_vitamin_homeostasis2.13820777
27MP0002064_seizures2.12505468
28MP0003632_abnormal_nervous_system2.10906161
29MP0005409_darkened_coat_color2.10105467
30MP0004859_abnormal_synaptic_plasticity2.08109260
31MP0004142_abnormal_muscle_tone2.05782726
32MP0000778_abnormal_nervous_system2.03056151
33MP0005171_absent_coat_pigmentation2.01736291
34MP0002229_neurodegeneration2.01291974
35MP0003195_calcinosis1.98773359
36MP0006036_abnormal_mitochondrial_physio1.93827917
37MP0000462_abnormal_digestive_system1.92088628
38MP0003136_yellow_coat_color1.91371225
39MP0005636_abnormal_mineral_homeostasis1.87168465
40MP0003186_abnormal_redox_activity1.87077523
41MP0003191_abnormal_cellular_cholesterol1.86768586
42MP0002796_impaired_skin_barrier1.84788582
43MP0010329_abnormal_lipoprotein_level1.84650147
44MP0002254_reproductive_system_inflammat1.82202013
45MP0003806_abnormal_nucleotide_metabolis1.80719864
46MP0009046_muscle_twitch1.76935338
47MP0005083_abnormal_biliary_tract1.68549733
48MP0000604_amyloidosis1.68425113
49MP0001661_extended_life_span1.64851743
50MP0009745_abnormal_behavioral_response1.61456430
51MP0009643_abnormal_urine_homeostasis1.61132878
52MP0000537_abnormal_urethra_morphology1.59524960
53MP0002734_abnormal_mechanical_nocicepti1.57605663
54MP0001764_abnormal_homeostasis1.54618790
55MP0000383_abnormal_hair_follicle1.52546028
56MP0002876_abnormal_thyroid_physiology1.51617430
57MP0005551_abnormal_eye_electrophysiolog1.49669010
58MP0001756_abnormal_urination1.49499363
59MP0009780_abnormal_chondrocyte_physiolo1.45361674
60MP0001440_abnormal_grooming_behavior1.43559993
61MP0005408_hypopigmentation1.43424201
62MP0003693_abnormal_embryo_hatching1.43038787
63MP0005501_abnormal_skin_physiology1.41891308
64MP0010678_abnormal_skin_adnexa1.40523980
65MP0001727_abnormal_embryo_implantation1.40251737
66MP0003635_abnormal_synaptic_transmissio1.39014738
67MP0000955_abnormal_spinal_cord1.38828467
68MP0009379_abnormal_foot_pigmentation1.34922224
69MP0002132_abnormal_respiratory_system1.34472083
70MP0001346_abnormal_lacrimal_gland1.34236185
71MP0002882_abnormal_neuron_morphology1.34093534
72MP0005410_abnormal_fertilization1.31026796
73MP0000678_abnormal_parathyroid_gland1.30282964
74MP0005058_abnormal_lysosome_morphology1.29408085
75MP0004185_abnormal_adipocyte_glucose1.27775147
76MP0005319_abnormal_enzyme/_coenzyme1.27670236
77MP0004381_abnormal_hair_follicle1.23312827
78MP0005379_endocrine/exocrine_gland_phen1.23302901
79MP0003941_abnormal_skin_development1.23258337
80MP0003879_abnormal_hair_cell1.21910619
81MP0002066_abnormal_motor_capabilities/c1.21794238
82MP0002163_abnormal_gland_morphology1.21645794
83MP0005670_abnormal_white_adipose1.21312677
84MP0000609_abnormal_liver_physiology1.20404776
85MP0005220_abnormal_exocrine_pancreas1.20093574
86MP0002089_abnormal_postnatal_growth/wei1.19641762
87MP0005386_behavior/neurological_phenoty1.15320673
88MP0004924_abnormal_behavior1.15320673
89MP0002752_abnormal_somatic_nervous1.13408312
90MP0001765_abnormal_ion_homeostasis1.11843063
91MP0001963_abnormal_hearing_physiology1.11102523
92MP0002572_abnormal_emotion/affect_behav1.10872546
93MP0006035_abnormal_mitochondrial_morpho1.10661076
94MP0003315_abnormal_perineum_morphology1.08877745
95MP0004858_abnormal_nervous_system1.08808895
96MP0004134_abnormal_chest_morphology1.08411790
97MP0001299_abnormal_eye_distance/1.08363157
98MP0002295_abnormal_pulmonary_circulatio1.06599479
99MP0005584_abnormal_enzyme/coenzyme_acti1.05940699
100MP0002067_abnormal_sensory_capabilities1.05669261
101MP0003631_nervous_system_phenotype1.05103703
102MP0000747_muscle_weakness1.04962879
103MP0008875_abnormal_xenobiotic_pharmacok1.02895036
104MP0000538_abnormal_urinary_bladder1.02884652
105MP0002098_abnormal_vibrissa_morphology1.02428306
106MP0010030_abnormal_orbit_morphology0.99491171
107MP0000477_abnormal_intestine_morphology0.99325025
108MP0002837_dystrophic_cardiac_calcinosis0.98624535
109MP0001881_abnormal_mammary_gland0.97869705
110MP0004957_abnormal_blastocyst_morpholog0.97593175
111MP0002138_abnormal_hepatobiliary_system0.97413080
112MP0001873_stomach_inflammation0.95679344
113MP0000490_abnormal_crypts_of0.95607814
114MP0001216_abnormal_epidermal_layer0.93917564
115MP0003283_abnormal_digestive_organ0.93802166
116MP0006072_abnormal_retinal_apoptosis0.93685647
117MP0005666_abnormal_adipose_tissue0.93638388
118MP0003075_altered_response_to0.92620784
119MP0005165_increased_susceptibility_to0.92493640
120MP0001944_abnormal_pancreas_morphology0.92257734
121MP0005195_abnormal_posterior_eye0.92111248
122MP0000566_synostosis0.90805065
123MP0003453_abnormal_keratinocyte_physiol0.90555124
124MP0004043_abnormal_pH_regulation0.90186707
125MP0000003_abnormal_adipose_tissue0.89848016
126MP0009333_abnormal_splenocyte_physiolog0.88954365
127MP0003938_abnormal_ear_development0.88848778
128MP0000681_abnormal_thyroid_gland0.88718490
129MP0004782_abnormal_surfactant_physiolog0.87795720
130MP0002909_abnormal_adrenal_gland0.87633399
131MP0002090_abnormal_vision0.86738255
132MP0009384_cardiac_valve_regurgitation0.86112137
133MP0002063_abnormal_learning/memory/cond0.85847040
134MP0002733_abnormal_thermal_nociception0.85679755
135MP0003172_abnormal_lysosome_physiology0.84057100
136MP0003718_maternal_effect0.83956033
137MP0000026_abnormal_inner_ear0.82347976
138MP0006082_CNS_inflammation0.81155342
139MP0000467_abnormal_esophagus_morphology0.80919335
140MP0004036_abnormal_muscle_relaxation0.78588509
141MP0003786_premature_aging0.78264912
142MP0000358_abnormal_cell_content/0.77667719
143MP0008438_abnormal_cutaneous_collagen0.77462879
144MP0001970_abnormal_pain_threshold0.76942377
145MP0001851_eye_inflammation0.76285813
146MP0005423_abnormal_somatic_nervous0.76103341
147MP0000647_abnormal_sebaceous_gland0.76043247
148MP0008569_lethality_at_weaning0.75977898
149MP0010352_gastrointestinal_tract_polyps0.75301926
150MP0005253_abnormal_eye_physiology0.75165761
151MP0005375_adipose_tissue_phenotype0.74368125
152MP0003866_abnormal_defecation0.71910970
153MP0001849_ear_inflammation0.71432205
154MP0002152_abnormal_brain_morphology0.70348518
155MP0000372_irregular_coat_pigmentation0.70119324
156MP0004272_abnormal_basement_membrane0.69422518
157MP0003868_abnormal_feces_composition0.68798133
158MP0003183_abnormal_peptide_metabolism0.68570768
159MP0000598_abnormal_liver_morphology0.67929400
160MP0009642_abnormal_blood_homeostasis0.67525633
161MP0002166_altered_tumor_susceptibility0.65758291
162MP0000013_abnormal_adipose_tissue0.63610520
163MP0001730_embryonic_growth_arrest0.63333985
164MP0005330_cardiomyopathy0.63285401
165MP0005623_abnormal_meninges_morphology0.62324085
166MP0003937_abnormal_limbs/digits/tail_de0.62285126
167MP0002736_abnormal_nociception_after0.61400288
168MP0005332_abnormal_amino_acid0.60632563
169MP0005310_abnormal_salivary_gland0.59673328
170MP0000762_abnormal_tongue_morphology0.58379201
171MP0001968_abnormal_touch/_nociception0.58144502
172MP0001664_abnormal_digestion0.56889516
173MP0004133_heterotaxia0.56226750
174MP0004145_abnormal_muscle_electrophysio0.55838834
175MP0008260_abnormal_autophagy0.55742051
176MP0003137_abnormal_impulse_conducting0.55387108
177MP0003011_delayed_dark_adaptation0.54503807
178MP0003633_abnormal_nervous_system0.54347978
179MP0001984_abnormal_olfaction0.53296048
180MP0002118_abnormal_lipid_homeostasis0.51560968

Predicted human phenotypes

RankGene SetZ-score
1Sensory axonal neuropathy (HP:0003390)6.70184102
2Parakeratosis (HP:0001036)6.11149840
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.78664884
4Degeneration of the lateral corticospinal tracts (HP:0002314)5.78664884
5Neurofibrillary tangles (HP:0002185)5.63681915
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.91811594
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.54600589
8Akinesia (HP:0002304)4.50813897
9Abnormality of the corticospinal tract (HP:0002492)4.30919694
10Increased serum pyruvate (HP:0003542)4.20141872
11Abnormality of glycolysis (HP:0004366)4.20141872
12Cerebral hypomyelination (HP:0006808)4.03104285
13Cerebral inclusion bodies (HP:0100314)3.98082893
14Congenital ichthyosiform erythroderma (HP:0007431)3.68766189
15Spastic paraparesis (HP:0002313)3.65380480
16Renal Fanconi syndrome (HP:0001994)3.49087527
17Peripheral hypomyelination (HP:0007182)3.43031755
18Spastic gait (HP:0002064)3.31468713
19Supranuclear gaze palsy (HP:0000605)3.30901155
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26650990
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26650990
22Leukodystrophy (HP:0002415)3.10965018
23Increased hepatocellular lipid droplets (HP:0006565)3.07121110
24Intention tremor (HP:0002080)3.06464120
25Abnormality of monocarboxylic acid metabolism (HP:0010996)2.99534957
26Abnormality of dicarboxylic acid metabolism (HP:0010995)2.88297609
27Dicarboxylic aciduria (HP:0003215)2.88297609
28Small epiphyses (HP:0010585)2.83732267
29Lipid accumulation in hepatocytes (HP:0006561)2.79562439
30Alacrima (HP:0000522)2.79554176
31Hyperammonemia (HP:0001987)2.79223068
32Abnormal tarsal ossification (HP:0008369)2.78988114
33Cerebral hemorrhage (HP:0001342)2.72235998
34Acute necrotizing encephalopathy (HP:0006965)2.71130256
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.69419574
36Slow saccadic eye movements (HP:0000514)2.68749246
37Hypoplastic pelvis (HP:0008839)2.68180847
38Cerebral edema (HP:0002181)2.67585260
39Right ventricular cardiomyopathy (HP:0011663)2.66303299
40Vascular calcification (HP:0004934)2.66213625
41Hypobetalipoproteinemia (HP:0003563)2.61549234
42Hypoglycemic coma (HP:0001325)2.60627283
43Erythroderma (HP:0001019)2.60625497
44Mitochondrial inheritance (HP:0001427)2.59094953
45Atonic seizures (HP:0010819)2.58551444
46Dysmetria (HP:0001310)2.57739659
47Vacuolated lymphocytes (HP:0001922)2.56342798
48Abnormality of carpal bone ossification (HP:0006257)2.55847550
49Autoamputation (HP:0001218)2.55554161
50Xanthomatosis (HP:0000991)2.54428767
51Increased circulating renin level (HP:0000848)2.50584827
52Diminished movement (HP:0002374)2.49960721
53Increased intramyocellular lipid droplets (HP:0012240)2.47679839
54Gout (HP:0001997)2.46748625
55Partial agenesis of the corpus callosum (HP:0001338)2.44658300
56Microretrognathia (HP:0000308)2.44088393
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.43709937
58Testicular atrophy (HP:0000029)2.43543030
59Acute encephalopathy (HP:0006846)2.42743492
60Abnormality of urine glucose concentration (HP:0011016)2.42644116
61Glycosuria (HP:0003076)2.42644116
62Vertebral compression fractures (HP:0002953)2.39925677
63Premature skin wrinkling (HP:0100678)2.37552279
64Lactic acidosis (HP:0003128)2.34832213
65Hepatocellular necrosis (HP:0001404)2.34485316
66Abnormality of fatty-acid metabolism (HP:0004359)2.34418181
67Methylmalonic acidemia (HP:0002912)2.32789642
68Adrenal hypoplasia (HP:0000835)2.31448973
69Hypokinesia (HP:0002375)2.31341359
70Cholecystitis (HP:0001082)2.31114268
71Abnormal gallbladder physiology (HP:0012438)2.31114268
72Stridor (HP:0010307)2.30820760
73Infantile muscular hypotonia (HP:0008947)2.28042192
74Onion bulb formation (HP:0003383)2.27453967
75Abnormal mitochondria in muscle tissue (HP:0008316)2.25206789
76Hyperphosphaturia (HP:0003109)2.25201784
77Thickened helices (HP:0000391)2.22772852
78Cardiovascular calcification (HP:0011915)2.21497945
79Generalized aminoaciduria (HP:0002909)2.21371330
80Lethargy (HP:0001254)2.21195530
81Flat acetabular roof (HP:0003180)2.21046556
82Late onset (HP:0003584)2.20519393
83Hepatosplenomegaly (HP:0001433)2.20329864
84Hypomagnesemia (HP:0002917)2.20269088
85Malnutrition (HP:0004395)2.19207257
86CNS hypomyelination (HP:0003429)2.18306029
87Anomalous pulmonary venous return (HP:0010772)2.18221470
88Progressive macrocephaly (HP:0004481)2.18034768
89Paraparesis (HP:0002385)2.17850976
90Pili torti (HP:0003777)2.17124242
91Cerebral palsy (HP:0100021)2.16783420
92Abolished electroretinogram (ERG) (HP:0000550)2.16738684
93Decreased lacrimation (HP:0000633)2.16554316
94Microvesicular hepatic steatosis (HP:0001414)2.16417364
95Abnormal hair laboratory examination (HP:0003328)2.15424550
96Insidious onset (HP:0003587)2.14668840
97Termporal pattern (HP:0011008)2.14668840
98Hyperglycinemia (HP:0002154)2.14649209
99Anteriorly placed anus (HP:0001545)2.13866194
100Prolonged partial thromboplastin time (HP:0003645)2.13794795
101Absent septum pellucidum (HP:0001331)2.13669419
102Cupped ear (HP:0000378)2.12726754
103Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10255420
104Abnormal auditory evoked potentials (HP:0006958)2.09784051
105Increased serum lactate (HP:0002151)2.09585234
106Nausea (HP:0002018)2.08836347
107Increased muscle lipid content (HP:0009058)2.08164980
108Type I transferrin isoform profile (HP:0003642)2.06456484
109Pheochromocytoma (HP:0002666)2.06411367
110Retinal dysplasia (HP:0007973)2.05547095
111Abnormality of renal resorption (HP:0011038)2.03970162
112Proximal tubulopathy (HP:0000114)2.03757245
113Barrel-shaped chest (HP:0001552)2.03104586
114Fat malabsorption (HP:0002630)2.01506289
115Scanning speech (HP:0002168)2.01144346
116Increased CSF lactate (HP:0002490)2.00522887
117Abdominal distention (HP:0003270)2.00156044
118Abnormal urine phosphate concentration (HP:0012599)1.99493356
1193-Methylglutaconic aciduria (HP:0003535)1.97150455
120Hypolipoproteinemia (HP:0010981)1.96899750
121Ileus (HP:0002595)1.96759477
122Neuroendocrine neoplasm (HP:0100634)1.95904078
123Abnormality of proline metabolism (HP:0010907)1.95255461
124Hydroxyprolinuria (HP:0003080)1.95255461
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94570422
126Abnormality of serine family amino acid metabolism (HP:0010894)1.94206995
127Abnormality of glycine metabolism (HP:0010895)1.94206995
128Reduced antithrombin III activity (HP:0001976)1.94101881
129Generalized myoclonic seizures (HP:0002123)1.93717405
130Exercise intolerance (HP:0003546)1.90949257
131Split foot (HP:0001839)1.90455896
132Purpura (HP:0000979)1.90189248
133Abnormality of the Achilles tendon (HP:0005109)1.89877229
134Hepatic necrosis (HP:0002605)1.88227958
135Axonal loss (HP:0003447)1.87410165
136Abnormality of the distal phalanges of the toes (HP:0010182)1.86733872
137Rhabdomyolysis (HP:0003201)1.86098249
138Intrahepatic cholestasis (HP:0001406)1.85686222
139Myokymia (HP:0002411)1.85314010
140Ragged-red muscle fibers (HP:0003200)1.84426828
141Renal tubular dysfunction (HP:0000124)1.83680180
142Synostosis involving the elbow (HP:0003938)1.83583252
143Humeroradial synostosis (HP:0003041)1.83583252
144Macrocytic anemia (HP:0001972)1.83508125
145Fetal akinesia sequence (HP:0001989)1.82165071
146Abnormality of vitamin metabolism (HP:0100508)1.81500024
147Abnormality of the septum pellucidum (HP:0007375)1.81219057
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80716289
149Abnormality of the pulmonary veins (HP:0011718)1.80594924
150Metabolic acidosis (HP:0001942)1.80524984
151Patchy hypopigmentation of hair (HP:0011365)1.80184553
152Abnormality of the vitreous humor (HP:0004327)1.79055176
153Poor speech (HP:0002465)1.78969578
154Systemic lupus erythematosus (HP:0002725)1.78950624
155Dysostosis multiplex (HP:0000943)1.78814378
156Hyperbilirubinemia (HP:0002904)1.77290467
157Growth hormone excess (HP:0000845)1.77287626
158Abnormal ossification of hand bones (HP:0005921)1.77081196
159Opisthotonus (HP:0002179)1.77020877
160Progressive neurologic deterioration (HP:0002344)1.76128929
161Ketosis (HP:0001946)1.76023601
162Abnormality of methionine metabolism (HP:0010901)1.75871973
163Vomiting (HP:0002013)1.74836568
164Hyperglycinuria (HP:0003108)1.74745922
165Postnatal microcephaly (HP:0005484)1.74689683
166Sparse eyelashes (HP:0000653)1.74436306
167White forelock (HP:0002211)1.73848224
168Abnormal umbilical cord blood vessels (HP:0011403)1.73313142
169Single umbilical artery (HP:0001195)1.73313142
170Abnormality of the fetal cardiovascular system (HP:0010948)1.73313142
171Deep venous thrombosis (HP:0002625)1.73153062
172Respiratory failure (HP:0002878)1.72927498
173Gastrointestinal stroma tumor (HP:0100723)1.72847546
174Abnormality of magnesium homeostasis (HP:0004921)1.71871722
175Myelomeningocele (HP:0002475)1.68310542
176Prolonged neonatal jaundice (HP:0006579)1.68043033
177Muscle hypertrophy of the lower extremities (HP:0008968)1.65575646
178Relative macrocephaly (HP:0004482)1.64867114
179Clumsiness (HP:0002312)1.64565821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.55912328
2NME25.11298784
3OXSR14.92922561
4TNIK4.49807808
5EPHA24.29756923
6VRK24.10718526
7CDK193.51970806
8BCR3.30578451
9EPHB13.05701466
10SMG13.02909894
11ICK3.00952866
12WNK42.99471531
13TESK12.88546257
14TRIB32.62150917
15IRAK32.60912219
16LMTK22.58461715
17PBK2.35804842
18PRPF4B2.31681183
19BCKDK2.31572845
20MET2.30755473
21MAPKAPK32.22586217
22NEK62.14502957
23MST1R2.10139931
24ERN12.09709567
25CSNK1G32.03748153
26PIM21.98153855
27LIMK11.91652911
28WNK11.84974955
29PKN11.83561365
30CSNK1A1L1.83291528
31MST41.81731463
32ILK1.81462381
33MAP3K121.69534018
34UHMK11.67728889
35PRKD31.63385952
36FGFR21.63116104
37PAK61.62253325
38BUB11.58212158
39PAK41.56215588
40CSNK1G11.54010359
41ROCK21.49950129
42BRAF1.48823863
43CSNK1G21.46205273
44MAP3K111.42803423
45LRRK21.37846755
46DAPK11.35105676
47RPS6KB21.33330002
48PRKCI1.31162787
49ARAF1.29650062
50PKN21.29628340
51EIF2AK11.24700473
52FGR1.24067843
53CLK11.20747815
54NTRK11.20229127
55SIK11.18176511
56DAPK31.14981048
57CAMK2B1.13821120
58EPHA41.12254049
59CAMK2D1.12163785
60EEF2K1.11573525
61PNCK1.09299414
62FGFR41.07758023
63TAOK21.05965067
64MYLK1.01234677
65RIPK11.00111629
66PRKG20.99182946
67CDK140.97888752
68SCYL20.97708771
69PAK30.96295202
70PRKCQ0.96217260
71VRK10.93749890
72NEK10.93121227
73PTK60.91011013
74ERBB40.90715693
75KDR0.90055089
76CASK0.87728476
77PDK20.86448110
78MAPKAPK50.82038717
79CDK150.81769099
80TAOK10.81302884
81MAP3K30.80779489
82TESK20.78697772
83MAP2K20.77841308
84CDK180.77775728
85CAMK2G0.77309333
86STK160.75623583
87CDK11A0.74435100
88TYRO30.74357578
89CDK50.74296573
90MAP2K60.72960168
91EPHB20.72563114
92MAPK110.72279207
93IRAK20.72238069
94AURKA0.69356342
95FYN0.66562378
96MAP3K80.65178488
97CAMK2A0.63183596
98MAP3K10.60148882
99AKT20.58722999
100PDPK10.57354396
101BMPR1B0.56617685
102IRAK10.56401092
103STK40.56383566
104DYRK20.56270434
105MARK10.56168530
106PTK20.56086061
107MAP3K20.55225526
108TBK10.54203677
109MAPK150.53478679
110FER0.53399102
111CDK70.51153601
112MARK20.49894696
113PRKCE0.49856652
114BRSK10.49761927
115CDK80.48365199
116MAP3K130.47272730
117ZAK0.46413701
118TAF10.45739263
119STK110.42933522
120CSNK1D0.42110653
121AURKB0.39981617
122PRKD20.39777385
123ROCK10.38366580
124PRKG10.37927121
125PIK3CA0.37539593
126ITK0.37301032
127PRKD10.36957067
128PAK10.36887119
129MKNK10.36679633
130STK380.36008365
131IRAK40.35179105
132PHKG20.34699440
133PHKG10.34699440
134CSNK2A10.34315007
135SGK2230.33896481
136SGK4940.33896481
137OBSCN0.33780817
138CSNK2A20.33396560
139ABL20.31945545
140TLK10.31882394
141FES0.31647141
142CSK0.30581874
143RPS6KA50.30554246
144PRKAA20.29127858
145GRK50.27566468
146ADRBK20.27528428
147CSNK1A10.27404821
148MUSK0.27002715
149PRKACB0.26671457
150AKT30.26217950
151ABL10.25611912
152GRK70.25345481
153MAPK130.25290713
154KSR20.25133802
155PDGFRB0.24317526
156IKBKB0.23925897
157MAPK70.23885056
158PRKACA0.23257473
159PTK2B0.22986847
160STK240.22230120
161NUAK10.22025379
162INSR0.21601088
163GRK60.21507509
164PRKCG0.21008210
165TRPM70.20420643
166TTK0.20355073
167MOS0.19513998
168MAPKAPK20.19421140
169PDK10.19409284
170PRKCD0.18793092
171LCK0.18557009
172EIF2AK30.17320435
173RAF10.16492840
174NME10.14849925

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.44360156
2Steroid biosynthesis_Homo sapiens_hsa001004.78960775
3Fatty acid elongation_Homo sapiens_hsa000624.29980555
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.04764084
5Oxidative phosphorylation_Homo sapiens_hsa001903.38294438
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.81727276
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.78426307
8Ether lipid metabolism_Homo sapiens_hsa005652.75563831
9Protein export_Homo sapiens_hsa030602.70589306
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.54434462
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45825257
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36416192
13Ribosome_Homo sapiens_hsa030102.33723568
14Fructose and mannose metabolism_Homo sapiens_hsa000512.31178505
15Parkinsons disease_Homo sapiens_hsa050122.31054270
16Sulfur metabolism_Homo sapiens_hsa009202.20063418
17Alzheimers disease_Homo sapiens_hsa050102.13006874
18Galactose metabolism_Homo sapiens_hsa000522.04885754
19Axon guidance_Homo sapiens_hsa043602.02624237
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98227149
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95200052
22Butanoate metabolism_Homo sapiens_hsa006501.86297931
23Other glycan degradation_Homo sapiens_hsa005111.85665725
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.82316289
25Arginine biosynthesis_Homo sapiens_hsa002201.72470507
26Biosynthesis of amino acids_Homo sapiens_hsa012301.67605517
27Carbon metabolism_Homo sapiens_hsa012001.67601181
28Sphingolipid metabolism_Homo sapiens_hsa006001.61040853
29Phenylalanine metabolism_Homo sapiens_hsa003601.57730651
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56656288
31Pentose phosphate pathway_Homo sapiens_hsa000301.52906091
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47962119
33Linoleic acid metabolism_Homo sapiens_hsa005911.46509207
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44916149
35Huntingtons disease_Homo sapiens_hsa050161.40610673
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39989037
37Collecting duct acid secretion_Homo sapiens_hsa049661.39889656
38Proteasome_Homo sapiens_hsa030501.38383322
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37031918
40Vitamin digestion and absorption_Homo sapiens_hsa049771.36840085
41Vibrio cholerae infection_Homo sapiens_hsa051101.33094560
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31507876
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.28568260
44Rheumatoid arthritis_Homo sapiens_hsa053231.27956162
45Fatty acid metabolism_Homo sapiens_hsa012121.27513185
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23045802
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22257470
48Glutathione metabolism_Homo sapiens_hsa004801.21388535
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20290501
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.19525603
51Cardiac muscle contraction_Homo sapiens_hsa042601.18662533
52Pyrimidine metabolism_Homo sapiens_hsa002401.18540504
53N-Glycan biosynthesis_Homo sapiens_hsa005101.18283446
54Base excision repair_Homo sapiens_hsa034101.13932945
55Arginine and proline metabolism_Homo sapiens_hsa003301.11801676
56Serotonergic synapse_Homo sapiens_hsa047261.10634706
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08658807
58Propanoate metabolism_Homo sapiens_hsa006401.05149559
59Peroxisome_Homo sapiens_hsa041461.05019073
60DNA replication_Homo sapiens_hsa030301.03637004
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03553060
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99731073
63Mineral absorption_Homo sapiens_hsa049780.97316329
64Renal cell carcinoma_Homo sapiens_hsa052110.95840427
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.91165446
66Arachidonic acid metabolism_Homo sapiens_hsa005900.89646420
67Starch and sucrose metabolism_Homo sapiens_hsa005000.84137506
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83792671
69Histidine metabolism_Homo sapiens_hsa003400.83177273
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.81025135
71Glutamatergic synapse_Homo sapiens_hsa047240.80976663
72Malaria_Homo sapiens_hsa051440.79536045
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78959797
74GABAergic synapse_Homo sapiens_hsa047270.78637462
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78348110
76Renin-angiotensin system_Homo sapiens_hsa046140.77877501
77Lysosome_Homo sapiens_hsa041420.77611347
78Phagosome_Homo sapiens_hsa041450.73901324
79Tight junction_Homo sapiens_hsa045300.73807629
80Vitamin B6 metabolism_Homo sapiens_hsa007500.72006928
81Endocytosis_Homo sapiens_hsa041440.67947814
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66974170
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66745269
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64532059
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64494155
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64348179
87Long-term depression_Homo sapiens_hsa047300.63166521
88Metabolic pathways_Homo sapiens_hsa011000.61669042
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61431840
90RNA polymerase_Homo sapiens_hsa030200.61232429
91Purine metabolism_Homo sapiens_hsa002300.59995005
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.59733354
93Chemical carcinogenesis_Homo sapiens_hsa052040.58594680
94Ras signaling pathway_Homo sapiens_hsa040140.56579462
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56369622
96Synaptic vesicle cycle_Homo sapiens_hsa047210.55140801
97Morphine addiction_Homo sapiens_hsa050320.54643193
98Ovarian steroidogenesis_Homo sapiens_hsa049130.51994369
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51897029
100Bile secretion_Homo sapiens_hsa049760.50655622
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.48967819
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.48796937
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48777679
104Mismatch repair_Homo sapiens_hsa034300.48616761
105ErbB signaling pathway_Homo sapiens_hsa040120.46441459
106Retinol metabolism_Homo sapiens_hsa008300.45934134
107Pyruvate metabolism_Homo sapiens_hsa006200.45783479
108Fatty acid degradation_Homo sapiens_hsa000710.45025135
109Autoimmune thyroid disease_Homo sapiens_hsa053200.44859345
110One carbon pool by folate_Homo sapiens_hsa006700.44175869
111Regulation of autophagy_Homo sapiens_hsa041400.42920613
112Tyrosine metabolism_Homo sapiens_hsa003500.41966506
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41515886
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41384175
115Nitrogen metabolism_Homo sapiens_hsa009100.41275258
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39138378
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37488615
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37389952
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.37110669
120ECM-receptor interaction_Homo sapiens_hsa045120.36594042
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36173309
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.35835944
123Nicotine addiction_Homo sapiens_hsa050330.35522150
124Phototransduction_Homo sapiens_hsa047440.30411637
125Fatty acid biosynthesis_Homo sapiens_hsa000610.30363449
126Cholinergic synapse_Homo sapiens_hsa047250.28814669
127Nucleotide excision repair_Homo sapiens_hsa034200.28048186
128Complement and coagulation cascades_Homo sapiens_hsa046100.26259890
129Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25109823
130Caffeine metabolism_Homo sapiens_hsa002320.23326103
131Circadian entrainment_Homo sapiens_hsa047130.22911151
132Glycerolipid metabolism_Homo sapiens_hsa005610.20427138
133Dopaminergic synapse_Homo sapiens_hsa047280.19818870
134Fat digestion and absorption_Homo sapiens_hsa049750.19530208
135Folate biosynthesis_Homo sapiens_hsa007900.18556428
136Basal transcription factors_Homo sapiens_hsa030220.17878578
137Sulfur relay system_Homo sapiens_hsa041220.17719138
138PPAR signaling pathway_Homo sapiens_hsa033200.16851395
139Tryptophan metabolism_Homo sapiens_hsa003800.16518002
140Salmonella infection_Homo sapiens_hsa051320.16462414
141Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15696287
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14345011
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13930422
144Pancreatic secretion_Homo sapiens_hsa049720.12141019
145beta-Alanine metabolism_Homo sapiens_hsa004100.11129309

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