TMEM135

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.04347604
2L-phenylalanine catabolic process (GO:0006559)6.04347604
3L-phenylalanine metabolic process (GO:0006558)5.68466726
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.68466726
5alpha-linolenic acid metabolic process (GO:0036109)5.47147280
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.16904124
7aromatic amino acid family catabolic process (GO:0009074)5.13552721
8fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.56359293
9bile acid biosynthetic process (GO:0006699)4.47682273
10regulation of cholesterol esterification (GO:0010872)4.47244199
11glyoxylate metabolic process (GO:0046487)4.41225266
12lysine metabolic process (GO:0006553)4.38303305
13lysine catabolic process (GO:0006554)4.38303305
14regulation of triglyceride catabolic process (GO:0010896)4.37667064
15sulfur amino acid catabolic process (GO:0000098)4.36915908
16indole-containing compound catabolic process (GO:0042436)4.35054707
17indolalkylamine catabolic process (GO:0046218)4.35054707
18tryptophan catabolic process (GO:0006569)4.35054707
19cysteine metabolic process (GO:0006534)4.34728977
20kynurenine metabolic process (GO:0070189)4.27426521
21urea cycle (GO:0000050)4.24480354
22urea metabolic process (GO:0019627)4.24480354
23high-density lipoprotein particle remodeling (GO:0034375)4.14391421
24tryptophan metabolic process (GO:0006568)4.12329499
25protein-lipid complex remodeling (GO:0034368)4.09178426
26macromolecular complex remodeling (GO:0034367)4.09178426
27plasma lipoprotein particle remodeling (GO:0034369)4.09178426
28short-chain fatty acid metabolic process (GO:0046459)4.06298322
29complement activation, alternative pathway (GO:0006957)4.03946853
30amino-acid betaine metabolic process (GO:0006577)3.97812271
31fatty acid beta-oxidation (GO:0006635)3.95547276
32low-density lipoprotein particle remodeling (GO:0034374)3.95162021
33acetyl-CoA metabolic process (GO:0006084)3.94096457
34plasma lipoprotein particle clearance (GO:0034381)3.92801546
35dicarboxylic acid biosynthetic process (GO:0043650)3.91473120
36nitrogen cycle metabolic process (GO:0071941)3.89004982
37peptidyl-glutamic acid carboxylation (GO:0017187)3.88373996
38protein carboxylation (GO:0018214)3.88373996
39bile acid metabolic process (GO:0008206)3.87606123
40triglyceride homeostasis (GO:0070328)3.86788860
41acylglycerol homeostasis (GO:0055090)3.86788860
42reverse cholesterol transport (GO:0043691)3.86273237
43homocysteine metabolic process (GO:0050667)3.85517347
44valine metabolic process (GO:0006573)3.83947542
45glutamate metabolic process (GO:0006536)3.78186973
46tyrosine metabolic process (GO:0006570)3.78112866
47fatty acid oxidation (GO:0019395)3.75515112
48lipid oxidation (GO:0034440)3.72621531
49fatty acid catabolic process (GO:0009062)3.72240315
50regulation of protein activation cascade (GO:2000257)3.70427575
51serine family amino acid catabolic process (GO:0009071)3.69776078
52regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.68423536
53cellular ketone body metabolic process (GO:0046950)3.67545971
54positive regulation of lipid catabolic process (GO:0050996)3.66156094
55aromatic amino acid family metabolic process (GO:0009072)3.65750616
56alpha-amino acid catabolic process (GO:1901606)3.64604699
57negative regulation of fibrinolysis (GO:0051918)3.64241024
58phospholipid efflux (GO:0033700)3.64024356
59nuclear pore complex assembly (GO:0051292)3.62452922
60monocarboxylic acid catabolic process (GO:0072329)3.58143600
61positive regulation of fatty acid beta-oxidation (GO:0032000)3.56612251
62cellular amino acid catabolic process (GO:0009063)3.51294915
63regulation of fibrinolysis (GO:0051917)3.50590897
64nuclear pore organization (GO:0006999)3.50230801
65fatty acid homeostasis (GO:0055089)3.48362784
66regulation of complement activation (GO:0030449)3.48325482
67coenzyme catabolic process (GO:0009109)3.47564282
68regulation of sequestering of triglyceride (GO:0010889)3.47217923
69cholesterol biosynthetic process (GO:0006695)3.47106335
70phospholipid homeostasis (GO:0055091)3.46470094
71cholesterol efflux (GO:0033344)3.45751101
72ethanol oxidation (GO:0006069)3.44906618
73cellular modified amino acid catabolic process (GO:0042219)3.42875288
74plasma lipoprotein particle assembly (GO:0034377)3.41417167
752-oxoglutarate metabolic process (GO:0006103)3.37361049
76carboxylic acid catabolic process (GO:0046395)3.35223620
77organic acid catabolic process (GO:0016054)3.35223620
78plasma lipoprotein particle organization (GO:0071827)3.34859475
79thioester biosynthetic process (GO:0035384)3.33981378
80acyl-CoA biosynthetic process (GO:0071616)3.33981378
81fatty-acyl-CoA biosynthetic process (GO:0046949)3.33855634
82fatty acid transmembrane transport (GO:1902001)3.33839400
83negative regulation of lipase activity (GO:0060192)3.32806129
84aspartate family amino acid catabolic process (GO:0009068)3.32104915
85carnitine metabolic process (GO:0009437)3.32015526
86very-low-density lipoprotein particle assembly (GO:0034379)3.31258275
87negative regulation of cholesterol transport (GO:0032375)3.27203900
88negative regulation of sterol transport (GO:0032372)3.27203900
89very long-chain fatty acid metabolic process (GO:0000038)3.26823558
90branched-chain amino acid catabolic process (GO:0009083)3.26546997
91biotin metabolic process (GO:0006768)3.24234231
92regulation of acyl-CoA biosynthetic process (GO:0050812)3.23431327
93positive regulation of fatty acid oxidation (GO:0046321)3.22584831
94sterol biosynthetic process (GO:0016126)3.20087172
95cellular biogenic amine catabolic process (GO:0042402)3.19746251
96amine catabolic process (GO:0009310)3.19746251
97linoleic acid metabolic process (GO:0043651)3.19730956
98regulation of cofactor metabolic process (GO:0051193)3.18088376
99regulation of coenzyme metabolic process (GO:0051196)3.18088376
100protein-lipid complex subunit organization (GO:0071825)3.17926111
101ketone body metabolic process (GO:1902224)3.16437817
102branched-chain amino acid metabolic process (GO:0009081)3.16235150
103low-density lipoprotein particle clearance (GO:0034383)3.15875407
104indolalkylamine metabolic process (GO:0006586)3.14633177
105COPII vesicle coating (GO:0048208)3.14145197
106bile acid and bile salt transport (GO:0015721)3.13641092
107acyl-CoA metabolic process (GO:0006637)3.12684315
108thioester metabolic process (GO:0035383)3.12684315
109protein-lipid complex assembly (GO:0065005)3.11525518
110mitotic G2/M transition checkpoint (GO:0044818)3.11114231
111protein localization to kinetochore (GO:0034501)3.10842042
112acylglycerol catabolic process (GO:0046464)3.09793346
113regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.07784337
114carnitine shuttle (GO:0006853)2.98232933
115long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.97183209
116regulation of sulfur metabolic process (GO:0042762)2.96695555
117fatty-acyl-CoA metabolic process (GO:0035337)2.85827381
118mitotic G2 DNA damage checkpoint (GO:0007095)2.85056060
119dorsal/ventral axis specification (GO:0009950)2.81284455
120response to lipoprotein particle (GO:0055094)2.80265393
121anterior/posterior axis specification, embryo (GO:0008595)2.78255305
122tricarboxylic acid cycle (GO:0006099)2.72589182
123female gonad development (GO:0008585)2.69489194
124somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67246296
125somatic hypermutation of immunoglobulin genes (GO:0016446)2.67246296
126DNA double-strand break processing (GO:0000729)2.66585743
127intracellular lipid transport (GO:0032365)2.66027996
128genitalia morphogenesis (GO:0035112)2.63381290
129regulation of centriole replication (GO:0046599)2.62205615
130triglyceride catabolic process (GO:0019433)2.62197404
131UDP-N-acetylglucosamine metabolic process (GO:0006047)2.61670796
132sister chromatid segregation (GO:0000819)2.60309393
133response to nitrosative stress (GO:0051409)2.59806947
134replication fork processing (GO:0031297)2.58817215
135long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.58062574
136embryonic retina morphogenesis in camera-type eye (GO:0060059)2.57693347
137neutral lipid catabolic process (GO:0046461)2.53099516
138protein localization to chromosome, centromeric region (GO:0071459)2.52103796
139pore complex assembly (GO:0046931)2.51838297
140L-serine metabolic process (GO:0006563)2.50697002
141regulation of centrosome cycle (GO:0046605)2.50301468
142regulation of centrosome duplication (GO:0010824)2.50172721
143positive regulation of glycolytic process (GO:0045821)2.46752782
144mitotic sister chromatid cohesion (GO:0007064)2.46114337
145coenzyme A metabolic process (GO:0015936)2.45397090
146regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.45117423
147chromatin remodeling at centromere (GO:0031055)2.44566774
148DNA strand renaturation (GO:0000733)2.43996897
149neurotransmitter catabolic process (GO:0042135)2.43584913
150double-strand break repair via nonhomologous end joining (GO:0006303)2.43349835
151non-recombinational repair (GO:0000726)2.43349835
152tRNA aminoacylation (GO:0043039)2.42344670
153amino acid activation (GO:0043038)2.42344670
154carnitine transport (GO:0015879)2.40897154
155amino-acid betaine transport (GO:0015838)2.40897154
156mitotic metaphase plate congression (GO:0007080)2.40463164
157intestinal absorption (GO:0050892)2.40319443
158regulation of mitotic spindle checkpoint (GO:1903504)2.39295550
159regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39295550
160CENP-A containing nucleosome assembly (GO:0034080)2.39290109
161tRNA aminoacylation for protein translation (GO:0006418)2.39064622
162zinc ion transport (GO:0006829)2.38694867
163regulation of translational fidelity (GO:0006450)2.38291266
164purine nucleobase biosynthetic process (GO:0009113)2.37658710
165negative regulation of DNA recombination (GO:0045910)2.37558679
166metaphase plate congression (GO:0051310)2.36318646
167intestinal cholesterol absorption (GO:0030299)2.36287871
168mitochondrial RNA metabolic process (GO:0000959)2.36231712
169mitotic sister chromatid segregation (GO:0000070)2.36184177
170regulation of sister chromatid cohesion (GO:0007063)2.31288818
171nucleotide-sugar biosynthetic process (GO:0009226)2.31239778
172tetrahydrofolate metabolic process (GO:0046653)2.31009192
173mitochondrial DNA replication (GO:0006264)2.30935138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.29970250
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.99734672
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.96519257
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.05304273
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.90691274
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.28648729
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.12646525
8E2F7_22180533_ChIP-Seq_HELA_Human3.88059470
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.76035365
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.22765069
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.91629929
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71661479
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.52973125
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43330505
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40265558
16AR_21909140_ChIP-Seq_LNCAP_Human2.37919189
17ELK1_19687146_ChIP-ChIP_HELA_Human2.28875875
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.26165332
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11424482
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08926283
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.04956753
22IGF1R_20145208_ChIP-Seq_DFB_Human2.02477940
23* FUS_26573619_Chip-Seq_HEK293_Human1.93708521
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.91564929
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90078890
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88806055
27CLOCK_20551151_ChIP-Seq_293T_Human1.87027015
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86132273
29EWS_26573619_Chip-Seq_HEK293_Human1.79379320
30* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76951840
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.71563696
32VDR_22108803_ChIP-Seq_LS180_Human1.65677784
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.63017201
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58215368
35GATA1_22025678_ChIP-Seq_K562_Human1.54651580
36* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52772417
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.52721699
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51339032
39* FOXA2_19822575_ChIP-Seq_HepG2_Human1.50122563
40GBX2_23144817_ChIP-Seq_PC3_Human1.48520797
41* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47035496
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44001020
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36649334
44ZNF274_21170338_ChIP-Seq_K562_Hela1.36631508
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35940280
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.34459896
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.33157146
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32519754
49* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31827343
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31797964
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31675190
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.30581541
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.28196939
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27670930
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26699330
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25615479
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25279648
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25125159
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.23458968
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23136309
61* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22832618
62* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21739454
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21632751
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21632751
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20823870
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19899991
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18417143
68* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16639342
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16170290
70HTT_18923047_ChIP-ChIP_STHdh_Human1.15693091
71VDR_23849224_ChIP-Seq_CD4+_Human1.15014689
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.14539236
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12561535
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12521324
75IRF1_19129219_ChIP-ChIP_H3396_Human1.10477755
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09120591
77* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08867839
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.08687659
79CDX2_22108803_ChIP-Seq_LS180_Human1.07511185
80* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07329177
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07031392
82MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06220438
83FOXP3_21729870_ChIP-Seq_TREG_Human1.05295629
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04895545
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04689313
86* STAT3_23295773_ChIP-Seq_U87_Human1.04378660
87* TCF4_22108803_ChIP-Seq_LS180_Human1.04337192
88BCAT_22108803_ChIP-Seq_LS180_Human1.03571235
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.02401839
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02227567
91* SRF_21415370_ChIP-Seq_HL-1_Mouse1.02177700
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01112629
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01013967
94* PIAS1_25552417_ChIP-Seq_VCAP_Human1.00756238
95* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00133594
96* EOMES_21245162_ChIP-Seq_HESCs_Human0.99985482
97TAF15_26573619_Chip-Seq_HEK293_Human0.99827162
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99748525
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98800005
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.97334624
101ER_23166858_ChIP-Seq_MCF-7_Human0.96819445
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96518408
103* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94814218
104MYC_18940864_ChIP-ChIP_HL60_Human0.94755574
105NANOG_18555785_Chip-Seq_ESCs_Mouse0.94524131
106* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94317681
107ESR2_21235772_ChIP-Seq_MCF-7_Human0.94073669
108DCP1A_22483619_ChIP-Seq_HELA_Human0.93660704
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92692322
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91682001
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91418455
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91399334
113AR_21572438_ChIP-Seq_LNCaP_Human0.90097381
114ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89161373
115* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88480997
116* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88135059
117MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85006473
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84700172
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83927823
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.82210878
121SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.81933460
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.81663351
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79835617
124* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79546793
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79173436
126RXR_22108803_ChIP-Seq_LS180_Human0.77632613
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77299526
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.74773844
129AR_25329375_ChIP-Seq_VCAP_Human0.74402950
130GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.74103755
131* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73601210
132EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73492680
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73460224
134VDR_24787735_ChIP-Seq_THP-1_Human0.73460079
135SOX2_20726797_ChIP-Seq_SW620_Human0.73137165
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72572848
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71640169
138RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70556368
139* FOXA1_25552417_ChIP-Seq_VCAP_Human0.70231475
140SOX2_21211035_ChIP-Seq_LN229_Gbm0.70026614
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.70019787
142CBP_20019798_ChIP-Seq_JUKART_Human0.70019787
143SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.69618286
144* CBP_21632823_ChIP-Seq_H3396_Human0.69452877
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.68913219
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.68870698
147* P300_19829295_ChIP-Seq_ESCs_Human0.68031259
148* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.67993530
149SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.67839971
150* GATA4_25053715_ChIP-Seq_YYC3_Human0.67702008
151SMAD4_21799915_ChIP-Seq_A2780_Human0.67470680
152* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.67450194
153* GATA2_19941826_ChIP-Seq_K562_Human0.66746864
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.66252256
155ESR1_15608294_ChIP-ChIP_MCF-7_Human0.65050645
156FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64935217
157SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63920116
158RNF2_18974828_ChIP-Seq_MESCs_Mouse0.63563436
159EZH2_18974828_ChIP-Seq_MESCs_Mouse0.63563436
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.63531740
161FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.63426966
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.62491275
163AHR_22903824_ChIP-Seq_MCF-7_Human0.62458743
164PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.62423688
165CDX2_20551321_ChIP-Seq_CACO-2_Human0.62216893
166EGR1_19032775_ChIP-ChIP_M12_Human0.61850479
167DROSHA_22980978_ChIP-Seq_HELA_Human0.60595672
168CTBP2_25329375_ChIP-Seq_LNCAP_Human0.60202693
169* TP63_23658742_ChIP-Seq_EP156T_Human0.59730742
170* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.59720449
171SALL4_18804426_ChIP-ChIP_XEN_Mouse0.59411322
172SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.59403740
173POU3F2_20337985_ChIP-ChIP_501MEL_Human0.58893455
174* SMAD4_21741376_ChIP-Seq_HESCs_Human0.58680192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.84614391
2MP0005360_urolithiasis6.22511325
3MP0005085_abnormal_gallbladder_physiolo5.17845373
4MP0005365_abnormal_bile_salt5.17116537
5MP0008875_abnormal_xenobiotic_pharmacok3.98345946
6MP0003890_abnormal_embryonic-extraembry3.70176782
7MP0010329_abnormal_lipoprotein_level3.57189370
8MP0003252_abnormal_bile_duct3.23954495
9MP0008057_abnormal_DNA_replication2.91090137
10MP0009840_abnormal_foam_cell2.83230920
11MP0005332_abnormal_amino_acid2.80257899
12MP0003191_abnormal_cellular_cholesterol2.68585805
13MP0005670_abnormal_white_adipose2.56013100
14MP0003195_calcinosis2.54452012
15MP0003806_abnormal_nucleotide_metabolis2.54006470
16MP0003941_abnormal_skin_development2.50952910
17MP0002118_abnormal_lipid_homeostasis2.33546243
18MP0006054_spinal_hemorrhage2.30021920
19MP0004264_abnormal_extraembryonic_tissu2.26877601
20MP0001666_abnormal_nutrient_absorption2.25464652
21MP0005083_abnormal_biliary_tract2.23386945
22MP0010094_abnormal_chromosome_stability2.20623586
23MP0004957_abnormal_blastocyst_morpholog2.16371780
24MP0004130_abnormal_muscle_cell2.13191904
25MP0004019_abnormal_vitamin_homeostasis2.07469503
26MP0000609_abnormal_liver_physiology2.02192549
27MP0003693_abnormal_embryo_hatching2.00547645
28MP0004272_abnormal_basement_membrane1.95468271
29MP0003690_abnormal_glial_cell1.79215684
30MP0002876_abnormal_thyroid_physiology1.74703726
31MP0005584_abnormal_enzyme/coenzyme_acti1.73333442
32MP0005319_abnormal_enzyme/_coenzyme1.71861089
33MP0010234_abnormal_vibrissa_follicle1.67248335
34MP0004147_increased_porphyrin_level1.64549229
35MP0003567_abnormal_fetal_cardiomyocyte1.62272385
36MP0003937_abnormal_limbs/digits/tail_de1.59270759
37MP0003718_maternal_effect1.56933173
38MP0001764_abnormal_homeostasis1.56023088
39MP0005666_abnormal_adipose_tissue1.55164086
40MP0008058_abnormal_DNA_repair1.55016448
41MP0005535_abnormal_body_temperature1.52005004
42MP0003111_abnormal_nucleus_morphology1.49829303
43MP0001293_anophthalmia1.47056927
44MP0003011_delayed_dark_adaptation1.45912092
45MP0005408_hypopigmentation1.42637892
46MP0002009_preneoplasia1.41800593
47MP0009643_abnormal_urine_homeostasis1.40965031
48MP0000604_amyloidosis1.40911080
49MP0005380_embryogenesis_phenotype1.39484478
50MP0001672_abnormal_embryogenesis/_devel1.39484478
51MP0000647_abnormal_sebaceous_gland1.37955393
52MP0008932_abnormal_embryonic_tissue1.36810468
53MP0002971_abnormal_brown_adipose1.35643063
54MP0002088_abnormal_embryonic_growth/wei1.35551379
55MP0003868_abnormal_feces_composition1.35507376
56MP0003984_embryonic_growth_retardation1.35280691
57MP0002837_dystrophic_cardiac_calcinosis1.34397209
58MP0002138_abnormal_hepatobiliary_system1.31093399
59MP0004043_abnormal_pH_regulation1.28936443
60MP0009703_decreased_birth_body1.28926539
61MP0002084_abnormal_developmental_patter1.22588345
62MP0009672_abnormal_birth_weight1.22262888
63MP0002233_abnormal_nose_morphology1.21949738
64MP0001730_embryonic_growth_arrest1.20821214
65MP0003329_amyloid_beta_deposits1.20649568
66MP0003077_abnormal_cell_cycle1.20421955
67MP0005334_abnormal_fat_pad1.18656723
68MP0003186_abnormal_redox_activity1.17868363
69MP0002102_abnormal_ear_morphology1.17242081
70MP0002078_abnormal_glucose_homeostasis1.17039792
71MP0002697_abnormal_eye_size1.16201299
72MP0001697_abnormal_embryo_size1.14180442
73MP0005058_abnormal_lysosome_morphology1.11776631
74MP0010352_gastrointestinal_tract_polyps1.07404029
75MP0005167_abnormal_blood-brain_barrier1.06484534
76MP0001756_abnormal_urination1.06474121
77MP0006036_abnormal_mitochondrial_physio1.05781244
78MP0003786_premature_aging1.04784475
79MP0003119_abnormal_digestive_system1.04594269
80MP0003950_abnormal_plasma_membrane1.04001944
81MP0001661_extended_life_span1.03864811
82MP0002638_abnormal_pupillary_reflex1.01723291
83MP0002086_abnormal_extraembryonic_tissu1.01443097
84MP0002111_abnormal_tail_morphology1.01417838
85MP0005375_adipose_tissue_phenotype1.00929176
86MP0008007_abnormal_cellular_replicative1.00820660
87MP0003943_abnormal_hepatobiliary_system1.00745175
88MP0004185_abnormal_adipocyte_glucose1.00731552
89MP0009384_cardiac_valve_regurgitation0.98815079
90MP0001286_abnormal_eye_development0.98030678
91MP0010678_abnormal_skin_adnexa0.97440368
92MP0002938_white_spotting0.97431830
93MP0004215_abnormal_myocardial_fiber0.96911077
94MP0009115_abnormal_fat_cell0.96397714
95MP0009697_abnormal_copulation0.96322612
96MP0009780_abnormal_chondrocyte_physiolo0.95645830
97MP0000372_irregular_coat_pigmentation0.94607871
98MP0003122_maternal_imprinting0.94178084
99MP0003385_abnormal_body_wall0.93843717
100MP0005448_abnormal_energy_balance0.93650848
101MP0005187_abnormal_penis_morphology0.93540358
102MP0004197_abnormal_fetal_growth/weight/0.91692911
103MP0003656_abnormal_erythrocyte_physiolo0.91284003
104MP0003283_abnormal_digestive_organ0.90209518
105MP0008995_early_reproductive_senescence0.89313732
106MP0009764_decreased_sensitivity_to0.88313658
107MP0000598_abnormal_liver_morphology0.88253915
108MP0002909_abnormal_adrenal_gland0.88103092
109MP0002254_reproductive_system_inflammat0.88097570
110MP0003315_abnormal_perineum_morphology0.87720822
111MP0003075_altered_response_to0.87468954
112MP0000013_abnormal_adipose_tissue0.87449782
113MP0003633_abnormal_nervous_system0.86907052
114MP0003183_abnormal_peptide_metabolism0.86136348
115MP0005647_abnormal_sex_gland0.85760955
116MP0009642_abnormal_blood_homeostasis0.85060773
117MP0005636_abnormal_mineral_homeostasis0.84434233
118MP0002085_abnormal_embryonic_tissue0.84291797
119MP0000230_abnormal_systemic_arterial0.83529654
120MP0002090_abnormal_vision0.82999622
121MP0000516_abnormal_urinary_system0.82087531
122MP0005367_renal/urinary_system_phenotyp0.82087531
123MP0009763_increased_sensitivity_to0.80823869
124MP0005451_abnormal_body_composition0.80586827
125MP0006072_abnormal_retinal_apoptosis0.80336627
126MP0008877_abnormal_DNA_methylation0.78431097
127MP0004885_abnormal_endolymph0.78169126
128MP0008469_abnormal_protein_level0.77322931
129MP0003705_abnormal_hypodermis_morpholog0.77157811
130MP0002080_prenatal_lethality0.76571813
131MP0010307_abnormal_tumor_latency0.75861675
132MP0005376_homeostasis/metabolism_phenot0.74855610
133MP0005395_other_phenotype0.74473817
134MP0001915_intracranial_hemorrhage0.73900015
135MP0003724_increased_susceptibility_to0.73101121
136MP0003935_abnormal_craniofacial_develop0.72030177
137MP0005253_abnormal_eye_physiology0.70546100
138MP0000383_abnormal_hair_follicle0.69836015
139MP0001501_abnormal_sleep_pattern0.69366039
140MP0003953_abnormal_hormone_level0.69086174
141MP0008872_abnormal_physiological_respon0.68200592
142MP0003172_abnormal_lysosome_physiology0.65002928
143MP0005084_abnormal_gallbladder_morpholo0.64116622
144MP0009765_abnormal_xenobiotic_induced0.63642194
145MP0001881_abnormal_mammary_gland0.63568354
146MP0002970_abnormal_white_adipose0.61802272
147MP0000003_abnormal_adipose_tissue0.61477499
148MP0008874_decreased_physiological_sensi0.61275790
149MP0002136_abnormal_kidney_physiology0.60516096
150MP0005266_abnormal_metabolism0.59366909
151MP0003959_abnormal_lean_body0.58754797
152MP0005551_abnormal_eye_electrophysiolog0.58545121
153MP0000639_abnormal_adrenal_gland0.56982143
154MP0003638_abnormal_response/metabolism_0.55639722
155MP0005166_decreased_susceptibility_to0.55317863
156MP0006082_CNS_inflammation0.55092567
157MP0003631_nervous_system_phenotype0.55011928
158MP0005452_abnormal_adipose_tissue0.52792711
159MP0004782_abnormal_surfactant_physiolog0.51730146
160MP0001765_abnormal_ion_homeostasis0.50453901
161MP0005646_abnormal_pituitary_gland0.48808490
162MP0005379_endocrine/exocrine_gland_phen0.48211993
163MP0005220_abnormal_exocrine_pancreas0.47777359
164MP0005464_abnormal_platelet_physiology0.46934135
165MP0002069_abnormal_eating/drinking_beha0.46200180
166MP0002229_neurodegeneration0.44298695
167MP0000920_abnormal_myelination0.43676671

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.70663386
2Xanthomatosis (HP:0000991)5.38280114
3Intrahepatic cholestasis (HP:0001406)5.18742691
4Deep venous thrombosis (HP:0002625)5.12189764
5Hyperlipoproteinemia (HP:0010980)4.74402991
6Complement deficiency (HP:0004431)4.65568785
7Prolonged partial thromboplastin time (HP:0003645)4.58038904
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.43809301
9Hyperglycinuria (HP:0003108)4.41996882
10Ketosis (HP:0001946)4.33302475
11Hypobetalipoproteinemia (HP:0003563)4.29199769
12Pancreatic islet-cell hyperplasia (HP:0004510)4.27349140
13Abnormality of glycine metabolism (HP:0010895)4.25380710
14Abnormality of serine family amino acid metabolism (HP:0010894)4.25380710
15Epidermoid cyst (HP:0200040)4.22202829
16Hyperammonemia (HP:0001987)4.16101690
17Hyperglycinemia (HP:0002154)4.14199113
18Hypoglycemic coma (HP:0001325)4.10471138
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.94083013
20Increased serum pyruvate (HP:0003542)3.86632775
21Hypoalphalipoproteinemia (HP:0003233)3.83751623
22Abnormality of fatty-acid metabolism (HP:0004359)3.81621124
23Hypolipoproteinemia (HP:0010981)3.80390086
24Ketoacidosis (HP:0001993)3.64539291
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.64366122
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.52899200
27Abnormality of glycolysis (HP:0004366)3.51014232
28Joint hemorrhage (HP:0005261)3.46630725
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.35246260
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.28927637
31Chromsome breakage (HP:0040012)3.27876861
32Hypercholesterolemia (HP:0003124)3.23656278
33Abnormality of complement system (HP:0005339)3.17504757
34Abnormality of the common coagulation pathway (HP:0010990)3.16677254
35Abnormality of the pancreatic islet cells (HP:0006476)3.12168854
36Abnormality of endocrine pancreas physiology (HP:0012093)3.12168854
37Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12098571
38Abnormality of methionine metabolism (HP:0010901)3.09029747
39Fat malabsorption (HP:0002630)3.04777446
40Abnormality of alanine metabolism (HP:0010916)2.95631579
41Hyperalaninemia (HP:0003348)2.95631579
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.95631579
43Systemic lupus erythematosus (HP:0002725)2.90729452
44Dicarboxylic aciduria (HP:0003215)2.85962861
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.85962861
46Embryonal renal neoplasm (HP:0011794)2.83470869
47Abnormality of purine metabolism (HP:0004352)2.78786048
48Skin nodule (HP:0200036)2.73899257
49Abnormality of chromosome stability (HP:0003220)2.73775065
50Generalized aminoaciduria (HP:0002909)2.73482795
51Gout (HP:0001997)2.72723283
52Abnormality of the intrinsic pathway (HP:0010989)2.72625922
53Conjugated hyperbilirubinemia (HP:0002908)2.69890921
54Bifid tongue (HP:0010297)2.65183283
55Metabolic acidosis (HP:0001942)2.63765229
56Abnormality of proline metabolism (HP:0010907)2.63752185
57Hydroxyprolinuria (HP:0003080)2.63752185
58Abnormality of serum amino acid levels (HP:0003112)2.59816241
59Myocardial infarction (HP:0001658)2.55198713
60Hypoglycemic seizures (HP:0002173)2.54200227
61Delayed CNS myelination (HP:0002188)2.53446680
62Abnormality of nucleobase metabolism (HP:0010932)2.50743190
63Lethargy (HP:0001254)2.45181054
64Hyperbilirubinemia (HP:0002904)2.42627820
65Cerebral edema (HP:0002181)2.42354684
66Amyloidosis (HP:0011034)2.40955118
67Vascular calcification (HP:0004934)2.40160823
68Glomerulonephritis (HP:0000099)2.40155906
69Meckel diverticulum (HP:0002245)2.40053467
70Pigmentary retinal degeneration (HP:0001146)2.37110911
71Sensorimotor neuropathy (HP:0007141)2.34508800
72Hepatoblastoma (HP:0002884)2.34113780
73Hepatocellular carcinoma (HP:0001402)2.33926024
74Abnormality of the ileum (HP:0001549)2.32413303
75Nephroblastoma (Wilms tumor) (HP:0002667)2.32043153
76Anal stenosis (HP:0002025)2.30559764
77Hypertriglyceridemia (HP:0002155)2.27574427
78Brushfield spots (HP:0001088)2.22250963
79Irritability (HP:0000737)2.20907239
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.20846428
81Absent eyebrow (HP:0002223)2.19444856
82Rhabdomyosarcoma (HP:0002859)2.18925642
83Steatorrhea (HP:0002570)2.18687856
84Neurofibrillary tangles (HP:0002185)2.17758362
85Vomiting (HP:0002013)2.16895553
86Volvulus (HP:0002580)2.15459968
87Pancreatitis (HP:0001733)2.15195232
88Myelomeningocele (HP:0002475)2.13398893
89Increased purine levels (HP:0004368)2.12925068
90Hyperuricemia (HP:0002149)2.12925068
91Mitral stenosis (HP:0001718)2.12317845
92Cardiovascular calcification (HP:0011915)2.11469088
93Myoglobinuria (HP:0002913)2.07403855
94Neoplasm of the adrenal gland (HP:0100631)2.06818771
95Oligomenorrhea (HP:0000876)2.04140044
96Abnormal lung lobation (HP:0002101)2.04047154
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.03575545
98Hyperinsulinemic hypoglycemia (HP:0000825)2.02936093
99Abnormal gallbladder morphology (HP:0012437)2.02332112
100Alkalosis (HP:0001948)2.02241519
101Late onset (HP:0003584)2.00242797
102Proximal tubulopathy (HP:0000114)1.99598846
103Cortical dysplasia (HP:0002539)1.98456872
104Facial shape deformation (HP:0011334)1.95474832
105Potter facies (HP:0002009)1.95474832
106Cholecystitis (HP:0001082)1.95236470
107Abnormal gallbladder physiology (HP:0012438)1.95236470
108Short tibia (HP:0005736)1.95155438
109Abnormality of the parathyroid morphology (HP:0011766)1.94910001
110Abnormality of pyrimidine metabolism (HP:0004353)1.94657472
111Renal cortical cysts (HP:0000803)1.94523110
112Cholelithiasis (HP:0001081)1.94455637
113Acanthocytosis (HP:0001927)1.94432517
114Disproportionate short-trunk short stature (HP:0003521)1.94251112
115Glycosuria (HP:0003076)1.93308584
116Abnormality of urine glucose concentration (HP:0011016)1.93308584
117Abnormality of the preputium (HP:0100587)1.92330715
118Neonatal onset (HP:0003623)1.89139047
119Abnormality of the renal cortex (HP:0011035)1.88601696
120Clitoromegaly (HP:0000057)1.87289131
121Missing ribs (HP:0000921)1.87248324
122Retinal atrophy (HP:0001105)1.87018956
123Abnormal pancreas size (HP:0012094)1.86794913
124Spontaneous abortion (HP:0005268)1.84840319
125Hypophosphatemic rickets (HP:0004912)1.83686317
126Hyperglycemia (HP:0003074)1.82968589
127Hemorrhage of the eye (HP:0011885)1.82940125
128Vaginal fistula (HP:0004320)1.82100300
129Status epilepticus (HP:0002133)1.81927296
130Absent radius (HP:0003974)1.81649435
131Nausea (HP:0002018)1.80802881
132Colon cancer (HP:0003003)1.80442398
133Cerebral inclusion bodies (HP:0100314)1.80246559
134Enlarged kidneys (HP:0000105)1.79348973
135Methylmalonic aciduria (HP:0012120)1.78207145
136Acute hepatic failure (HP:0006554)1.77539555
137Recurrent gram-negative bacterial infections (HP:0005420)1.77490818
138Symptomatic seizures (HP:0011145)1.77006329
139Biliary tract neoplasm (HP:0100574)1.76377157
140Papillary thyroid carcinoma (HP:0002895)1.76254647
141Rectovaginal fistula (HP:0000143)1.76024874
142Rectal fistula (HP:0100590)1.76024874
143Sloping forehead (HP:0000340)1.74246326
144Breast carcinoma (HP:0003002)1.73541972
145Ovarian neoplasm (HP:0100615)1.72835596
146Gonadotropin excess (HP:0000837)1.72549326
147Small intestinal stenosis (HP:0012848)1.72434965
148Duodenal stenosis (HP:0100867)1.72434965
149Epiphyseal stippling (HP:0010655)1.68870004
150Absent forearm bone (HP:0003953)1.67402245
151Aplasia involving forearm bones (HP:0009822)1.67402245
152Abnormality of the duodenum (HP:0002246)1.67076139
153Subcapsular cataract (HP:0000523)1.66298109
154Abnormality of the lumbar spine (HP:0100712)1.64624025
155Genital tract atresia (HP:0001827)1.64042751
156Megaloblastic anemia (HP:0001889)1.63654039
157Abnormal tarsal ossification (HP:0008369)1.62111750
158Thyroid carcinoma (HP:0002890)1.61691613
159Hypoplastic pelvis (HP:0008839)1.61030739
160Embryonal neoplasm (HP:0002898)1.60087320
161Septate vagina (HP:0001153)1.59334002
162Abnormal biliary tract morphology (HP:0012440)1.59225460
163Hypothermia (HP:0002045)1.57035145
164Vaginal atresia (HP:0000148)1.55676913
165Tubulointerstitial nephritis (HP:0001970)1.54821862
166Glioma (HP:0009733)1.53651331
167Median cleft lip (HP:0000161)1.53433141
168Tubular atrophy (HP:0000092)1.52271335
169Bicornuate uterus (HP:0000813)1.51864932
170Neoplasm of the small intestine (HP:0100833)1.51172451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.52075748
2ACVR1B3.90384231
3SIK13.46345969
4MST43.20578234
5CAMK1D3.05381014
6ERN12.91017003
7INSRR2.82198098
8TTK2.60506874
9TSSK62.55224444
10EIF2AK32.47745792
11BMPR1B2.38716487
12PBK2.32740341
13AKT32.28446192
14BCR2.13737042
15CAMK1G2.13532086
16SRPK12.05193989
17ZAK2.04820758
18EIF2AK12.04431249
19TNIK2.02736714
20MKNK21.99973382
21TRIM281.98148644
22STK31.98031658
23TAOK31.95918199
24BRSK21.91302353
25FGFR41.88618502
26NEK11.86021526
27MKNK11.81239308
28DAPK21.80259804
29MAP2K41.77288156
30PLK31.75960040
31NUAK11.74702152
32TRIB31.70743973
33PLK41.66584412
34PDK21.58478460
35MST1R1.54397798
36BUB11.47003312
37PDK31.46871729
38PDK41.46871729
39STK38L1.44489769
40FRK1.44450232
41FGFR11.44033694
42PRKAA21.42294774
43WEE11.41814366
44WNK41.41129155
45OXSR11.37412008
46PKN21.34645850
47ERBB41.33597323
48TGFBR21.32920928
49MAPK121.32378706
50MAP3K131.32332106
51LMTK21.31612517
52NEK91.30943294
53ERBB31.25267675
54PINK11.23240186
55MAPK111.14056445
56NTRK11.13720149
57PLK11.11656998
58JAK11.07905107
59JAK21.06777976
60WNK31.06554786
61PDPK11.04694388
62NEK21.04465212
63STK391.02963849
64MAP4K21.02905105
65LATS11.02744589
66FLT31.02616609
67RIPK41.01439721
68CAMKK11.00741987
69MAPK151.00384457
70SGK2230.99848892
71SGK4940.99848892
72IRAK30.99758689
73CDC70.99172946
74RIPK10.98633228
75PIK3CG0.97102273
76TAF10.94891877
77MAP3K120.94678168
78PDK10.94614072
79CSNK1G10.92839191
80FGFR20.92593970
81MAP3K70.92576675
82SGK30.90790888
83PASK0.90768510
84PRKAA10.87903815
85EPHB10.86894877
86SGK20.83241573
87RPS6KB20.83004952
88PRKCZ0.82559888
89RET0.79704406
90PRKACG0.79268310
91ATM0.76539133
92ATR0.76388710
93EEF2K0.76182974
94MET0.73563549
95KSR20.73284494
96CASK0.73264423
97FGFR30.72670351
98TYK20.72572158
99LATS20.71886318
100VRK10.71651834
101IGF1R0.71552425
102MAP3K90.70780572
103TGFBR10.69814914
104EIF2AK20.69767691
105NLK0.69295982
106MAPK70.67504860
107PHKG10.67359510
108PHKG20.67359510
109MAPK40.66878421
110PTK60.66869119
111YES10.66166787
112PIK3CA0.63117564
113CHEK20.62598878
114STK380.61966366
115GSK3A0.61703669
116MUSK0.61058472
117ABL20.60291476
118MAPK130.60168837
119PRKCH0.59713364
120MAP3K40.58871035
121EPHA40.58059728
122SCYL20.57833543
123GRK10.57450104
124CAMKK20.57407835
125MAP2K70.57248967
126MAP3K140.55892188
127MAP2K10.55739477
128GRK70.55348830
129TBK10.54886322
130CDK30.54254605
131DYRK30.53363162
132PAK30.52699312
133RPS6KA40.52409598
134TNK20.52145877
135MAP3K60.50453399
136CSF1R0.49165181
137MINK10.48175030
138CAMK2G0.47793042
139SGK10.46894908
140AURKB0.46861659
141CHEK10.46472611
142CSNK1E0.46301468
143CSK0.46232474
144NTRK30.45843781
145STK40.45560511
146ERBB20.45529999
147TIE10.45393779
148MELK0.43930310
149MAP3K20.41416295
150PRKCE0.41086597
151PRKCQ0.40627574
152MAP3K10.40529736
153BRD40.40484776
154RPS6KB10.40320223
155GRK50.37921087
156CDK50.37311514
157CDK60.37271720
158PLK20.37161826
159CAMK2A0.35724076
160PRKCG0.35037529
161AKT20.34999320
162PRKDC0.34974191
163CDK10.34653538
164WNK10.34278632
165PKN10.33475923
166CSNK1A1L0.33459171
167PNCK0.33007341
168NEK60.32695926
169FER0.32319454
170STK100.31478110
171CDK70.29187445
172CSNK1A10.28932660
173CSNK2A10.27615171

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.59741289
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.58392832
3Fatty acid degradation_Homo sapiens_hsa000712.86503790
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.85209981
5Propanoate metabolism_Homo sapiens_hsa006402.81662980
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69253490
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.67275732
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.55513550
9Arginine biosynthesis_Homo sapiens_hsa002202.52448242
10Fatty acid metabolism_Homo sapiens_hsa012122.50155702
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45806828
12Tryptophan metabolism_Homo sapiens_hsa003802.40800877
13PPAR signaling pathway_Homo sapiens_hsa033202.35232808
14Butanoate metabolism_Homo sapiens_hsa006502.33519275
15Peroxisome_Homo sapiens_hsa041462.15417808
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09355870
17Complement and coagulation cascades_Homo sapiens_hsa046102.05072212
18Non-homologous end-joining_Homo sapiens_hsa034501.93258167
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.90570353
20One carbon pool by folate_Homo sapiens_hsa006701.84159720
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83916833
22beta-Alanine metabolism_Homo sapiens_hsa004101.83050783
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82585707
24Fatty acid elongation_Homo sapiens_hsa000621.79707001
25Pyruvate metabolism_Homo sapiens_hsa006201.69882894
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69748595
27Fatty acid biosynthesis_Homo sapiens_hsa000611.65441156
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59780072
29Histidine metabolism_Homo sapiens_hsa003401.56096120
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54335608
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54223484
32Sulfur metabolism_Homo sapiens_hsa009201.54012224
33Caffeine metabolism_Homo sapiens_hsa002321.51327780
34Staphylococcus aureus infection_Homo sapiens_hsa051501.49668268
35Bile secretion_Homo sapiens_hsa049761.44857183
36Steroid biosynthesis_Homo sapiens_hsa001001.44352614
37Chemical carcinogenesis_Homo sapiens_hsa052041.44249727
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43435556
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43368792
40Mismatch repair_Homo sapiens_hsa034301.38454971
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.33964952
42Basal transcription factors_Homo sapiens_hsa030221.32965682
43Protein export_Homo sapiens_hsa030601.32638920
44Retinol metabolism_Homo sapiens_hsa008301.30304400
45Fat digestion and absorption_Homo sapiens_hsa049751.29301853
46Carbon metabolism_Homo sapiens_hsa012001.29215281
47Phenylalanine metabolism_Homo sapiens_hsa003601.28225922
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23724577
49Starch and sucrose metabolism_Homo sapiens_hsa005001.20597672
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18524112
51Fanconi anemia pathway_Homo sapiens_hsa034601.18056976
52Homologous recombination_Homo sapiens_hsa034401.17923856
53Glycerolipid metabolism_Homo sapiens_hsa005611.17506931
54Tyrosine metabolism_Homo sapiens_hsa003501.17250870
55ABC transporters_Homo sapiens_hsa020101.16858828
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14292907
57RNA transport_Homo sapiens_hsa030131.12261746
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.02610562
59Nucleotide excision repair_Homo sapiens_hsa034200.96895861
60RNA degradation_Homo sapiens_hsa030180.95099770
61Biosynthesis of amino acids_Homo sapiens_hsa012300.93560998
62Vitamin digestion and absorption_Homo sapiens_hsa049770.91319511
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89156534
64Selenocompound metabolism_Homo sapiens_hsa004500.88056717
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.84372727
66DNA replication_Homo sapiens_hsa030300.84207122
67Cell cycle_Homo sapiens_hsa041100.82656606
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.81914236
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78380932
70N-Glycan biosynthesis_Homo sapiens_hsa005100.76928277
71Arginine and proline metabolism_Homo sapiens_hsa003300.74916612
72Lysine degradation_Homo sapiens_hsa003100.74387020
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71344337
74Proteasome_Homo sapiens_hsa030500.70013258
75mRNA surveillance pathway_Homo sapiens_hsa030150.68900879
76Folate biosynthesis_Homo sapiens_hsa007900.67945328
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65431426
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63054781
79TGF-beta signaling pathway_Homo sapiens_hsa043500.59571663
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.59015033
81Sphingolipid metabolism_Homo sapiens_hsa006000.54731763
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53910085
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53829095
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.53824978
85Base excision repair_Homo sapiens_hsa034100.53112968
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52745197
87Vitamin B6 metabolism_Homo sapiens_hsa007500.52465847
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51268463
89Purine metabolism_Homo sapiens_hsa002300.50577851
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.49585555
91RNA polymerase_Homo sapiens_hsa030200.47783825
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46144488
93Glutathione metabolism_Homo sapiens_hsa004800.43757804
94Circadian rhythm_Homo sapiens_hsa047100.43617133
95Pentose phosphate pathway_Homo sapiens_hsa000300.43009376
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42990571
97Thyroid cancer_Homo sapiens_hsa052160.42176235
98Metabolic pathways_Homo sapiens_hsa011000.41346796
99Insulin resistance_Homo sapiens_hsa049310.41200292
100Hippo signaling pathway_Homo sapiens_hsa043900.40765541
101Oocyte meiosis_Homo sapiens_hsa041140.38827139
102Sulfur relay system_Homo sapiens_hsa041220.38464788
103Prion diseases_Homo sapiens_hsa050200.35776395
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33133029
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32927240
106Spliceosome_Homo sapiens_hsa030400.32630948
107Glucagon signaling pathway_Homo sapiens_hsa049220.29758180
108Fructose and mannose metabolism_Homo sapiens_hsa000510.29748321
109Lysosome_Homo sapiens_hsa041420.29398289
110AMPK signaling pathway_Homo sapiens_hsa041520.28238816
111Linoleic acid metabolism_Homo sapiens_hsa005910.26373706
112Renin-angiotensin system_Homo sapiens_hsa046140.25264877
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21516880
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20661640
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19876849
116Galactose metabolism_Homo sapiens_hsa000520.19358121
117GABAergic synapse_Homo sapiens_hsa047270.17557851
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.17382186
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16317821
120Type II diabetes mellitus_Homo sapiens_hsa049300.13114590
121Renin secretion_Homo sapiens_hsa049240.13098461
122Ether lipid metabolism_Homo sapiens_hsa005650.12259833
123Other glycan degradation_Homo sapiens_hsa005110.11905396
124Insulin signaling pathway_Homo sapiens_hsa049100.11783612
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07521720
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.05432861
127Mineral absorption_Homo sapiens_hsa049780.03710662
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.03422039
129Ovarian steroidogenesis_Homo sapiens_hsa049130.00600717
130Thyroid hormone synthesis_Homo sapiens_hsa049180.00273230
131Salivary secretion_Homo sapiens_hsa04970-0.0273409
132Collecting duct acid secretion_Homo sapiens_hsa04966-0.0264424
133Synaptic vesicle cycle_Homo sapiens_hsa04721-0.0230077
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0017423

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