TMEM126B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial transmembrane protein which is a component of the mitochondrial complex I assembly complex. The encoded protein serves as an assembly factor that is required for formation of the membrane arm of the complex. It interacts with NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 13. Naturally occurring mutations in this gene are associated with isolated complex I deficiency. A pseudogene of this gene has been defined on chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.55579911
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.83777300
3protein complex biogenesis (GO:0070271)4.63641165
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.62824759
5DNA double-strand break processing (GO:0000729)4.25054416
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.20150960
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.20150960
8NADH dehydrogenase complex assembly (GO:0010257)4.20150960
9chromatin remodeling at centromere (GO:0031055)4.13638888
10presynaptic membrane assembly (GO:0097105)4.04208899
11chaperone-mediated protein transport (GO:0072321)4.03527134
12negative regulation of synaptic transmission, GABAergic (GO:0032229)4.02348713
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.00589428
14CENP-A containing nucleosome assembly (GO:0034080)4.00403055
15respiratory electron transport chain (GO:0022904)4.00212153
16mitochondrial respiratory chain complex assembly (GO:0033108)3.96815898
17electron transport chain (GO:0022900)3.90430980
18polyketide metabolic process (GO:0030638)3.88583950
19doxorubicin metabolic process (GO:0044598)3.88583950
20daunorubicin metabolic process (GO:0044597)3.88583950
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.87136259
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.82445247
23DNA replication checkpoint (GO:0000076)3.79828319
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.79583191
25transferrin transport (GO:0033572)3.77859479
26ATP synthesis coupled proton transport (GO:0015986)3.77208762
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.77208762
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.73398883
29presynaptic membrane organization (GO:0097090)3.72214318
30protein neddylation (GO:0045116)3.71630987
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71168423
32purine nucleobase biosynthetic process (GO:0009113)3.68823407
33energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.67347978
34ATP hydrolysis coupled proton transport (GO:0015991)3.67347978
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.66505225
36negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.62896738
37negative regulation of ligase activity (GO:0051352)3.62896738
38neuron cell-cell adhesion (GO:0007158)3.61953339
39transcription elongation from RNA polymerase III promoter (GO:0006385)3.59058547
40termination of RNA polymerase III transcription (GO:0006386)3.59058547
41ferric iron transport (GO:0015682)3.58728355
42trivalent inorganic cation transport (GO:0072512)3.58728355
43water-soluble vitamin biosynthetic process (GO:0042364)3.57169256
44regulation of cellular amino acid metabolic process (GO:0006521)3.53865723
45establishment of integrated proviral latency (GO:0075713)3.52546124
46platelet dense granule organization (GO:0060155)3.50014348
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48879423
48histone exchange (GO:0043486)3.45659812
49succinate metabolic process (GO:0006105)3.45210827
50DNA catabolic process, exonucleolytic (GO:0000738)3.44270673
51DNA deamination (GO:0045006)3.42440573
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.41341113
53cytochrome complex assembly (GO:0017004)3.39805567
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39081000
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39081000
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39081000
57pseudouridine synthesis (GO:0001522)3.39014938
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.33799167
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.33799167
60phagosome maturation (GO:0090382)3.28327488
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28327036
62DNA damage response, detection of DNA damage (GO:0042769)3.28038974
63IMP biosynthetic process (GO:0006188)3.27140344
64regulation of mitotic spindle checkpoint (GO:1903504)3.26683298
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.26683298
66negative regulation of DNA-dependent DNA replication (GO:2000104)3.26069894
67dopamine transport (GO:0015872)3.24704186
68rRNA modification (GO:0000154)3.23968825
69signal transduction involved in DNA damage checkpoint (GO:0072422)3.23730080
70signal transduction involved in DNA integrity checkpoint (GO:0072401)3.23730080
71signal transduction involved in cell cycle checkpoint (GO:0072395)3.22353367
72positive regulation of ligase activity (GO:0051351)3.20281695
73regulation of mitochondrial translation (GO:0070129)3.18341971
74inner mitochondrial membrane organization (GO:0007007)3.17117855
75startle response (GO:0001964)3.16706721
76aerobic respiration (GO:0009060)3.16471496
77nucleobase biosynthetic process (GO:0046112)3.15451545
78synaptic vesicle exocytosis (GO:0016079)3.15252139
79negative regulation of dendrite morphogenesis (GO:0050774)3.14944596
80maturation of 5.8S rRNA (GO:0000460)3.13097569
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11130735
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11130735
83histone mRNA metabolic process (GO:0008334)3.08389901
84vocalization behavior (GO:0071625)3.06260740
85cullin deneddylation (GO:0010388)3.05194836
86protein targeting to mitochondrion (GO:0006626)3.04544583
87neurotransmitter-gated ion channel clustering (GO:0072578)3.01430219
88positive regulation of mitochondrial fission (GO:0090141)3.01342053
89synapsis (GO:0007129)3.00719032
90respiratory chain complex IV assembly (GO:0008535)3.00202912
91ribosome assembly (GO:0042255)2.99692276
92regulation of ubiquitin-protein transferase activity (GO:0051438)2.97894257
93ribosomal large subunit biogenesis (GO:0042273)2.97607780
94positive regulation of protein homodimerization activity (GO:0090073)2.95608192
95signal peptide processing (GO:0006465)2.94878139
96protein localization to mitochondrion (GO:0070585)2.94410512
97somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.93612105
98isotype switching (GO:0045190)2.93612105
99somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.93612105
100regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.93424738
101opioid receptor signaling pathway (GO:0038003)2.93205750
102NADH metabolic process (GO:0006734)2.93078006
103spliceosomal snRNP assembly (GO:0000387)2.92812940
104regulation of ligase activity (GO:0051340)2.92474050
105peptidyl-histidine modification (GO:0018202)2.92094733
106DNA replication-independent nucleosome organization (GO:0034724)2.91810157
107DNA replication-independent nucleosome assembly (GO:0006336)2.91810157
108gamma-aminobutyric acid signaling pathway (GO:0007214)2.91754087
109postsynaptic membrane organization (GO:0001941)2.91348085
110kinetochore organization (GO:0051383)2.90289917
111regulation of helicase activity (GO:0051095)2.89285485
112establishment of protein localization to mitochondrion (GO:0072655)2.88718993
113neuron-neuron synaptic transmission (GO:0007270)2.88638501
114replication fork processing (GO:0031297)2.88456533
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86832258
116tricarboxylic acid cycle (GO:0006099)2.86777037
117lactate metabolic process (GO:0006089)2.85130964
118neuronal action potential propagation (GO:0019227)2.84636988
119intracellular protein transmembrane import (GO:0044743)2.83731695
120rRNA methylation (GO:0031167)2.80470120
121regulation of penile erection (GO:0060405)2.80459175
122regulation of meiosis I (GO:0060631)2.80091413
123nucleotide transmembrane transport (GO:1901679)2.79652429
124hydrogen ion transmembrane transport (GO:1902600)2.79156222
125IMP metabolic process (GO:0046040)2.77029028
126cellular ketone body metabolic process (GO:0046950)2.76863238
127mitotic metaphase plate congression (GO:0007080)2.76167134
128resolution of meiotic recombination intermediates (GO:0000712)2.76061382
129righting reflex (GO:0060013)2.75944943
130oxidative phosphorylation (GO:0006119)2.75940624
131female mating behavior (GO:0060180)2.75887933
132ribosomal small subunit assembly (GO:0000028)2.75883801
133protein-cofactor linkage (GO:0018065)2.75356063
134RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74785856
135kinetochore assembly (GO:0051382)2.74757355
136serotonin receptor signaling pathway (GO:0007210)2.73816461
137recombinational repair (GO:0000725)2.73222393
138rRNA processing (GO:0006364)2.72624306
139membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72396982
140synaptic vesicle docking involved in exocytosis (GO:0016081)2.72253179
141striatum development (GO:0021756)2.71878253
142positive regulation of amino acid transport (GO:0051957)2.71820470
143regulation of glutamate secretion (GO:0014048)2.70802824
144regulation of glutamate receptor signaling pathway (GO:1900449)2.67660735
145aminoglycoside antibiotic metabolic process (GO:0030647)2.67582212
146proton transport (GO:0015992)2.67160032
147positive regulation of action potential (GO:0045760)2.66108406
148protein localization to cilium (GO:0061512)2.65277125
149protein deneddylation (GO:0000338)2.64197855
150response to histamine (GO:0034776)2.63043708
151hydrogen transport (GO:0006818)2.62928811
152positive regulation of synapse assembly (GO:0051965)2.60878172
153ER overload response (GO:0006983)2.59034647
154behavioral response to nicotine (GO:0035095)2.57894620
155synaptic transmission, glutamatergic (GO:0035249)2.54923603
156long-chain fatty acid biosynthetic process (GO:0042759)2.54450911
157protein localization to synapse (GO:0035418)2.53804602
158positive regulation of synaptic transmission, GABAergic (GO:0032230)2.50346762
159regulation of synaptic transmission, GABAergic (GO:0032228)2.50338855
160long-term synaptic potentiation (GO:0060291)2.49721456
161regulation of cell communication by electrical coupling (GO:0010649)2.49320923
162adenosine metabolic process (GO:0046085)2.48590552
163negative regulation of dendrite development (GO:2000171)2.47920348
164regulation of protein kinase A signaling (GO:0010738)2.47868764
165pH reduction (GO:0045851)2.47755563
166aggressive behavior (GO:0002118)2.46886393
167glutamate secretion (GO:0014047)2.46453409
168response to cocaine (GO:0042220)2.46295437
169regulation of dopamine metabolic process (GO:0042053)2.45718265
170regulation of catecholamine metabolic process (GO:0042069)2.45718265
171regulation of amino acid transport (GO:0051955)2.45680469
172cellular respiration (GO:0045333)2.44940291
173regulation of synaptic vesicle exocytosis (GO:2000300)2.44457345
174peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.44012456
175negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.43396842
176regulation of action potential (GO:0098900)2.41114328
177ionotropic glutamate receptor signaling pathway (GO:0035235)2.40963347
178oxaloacetate metabolic process (GO:0006107)2.40957832
179intracellular pH reduction (GO:0051452)2.40537743
180peroxisome fission (GO:0016559)2.40506354

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.66063293
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.22728219
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.86421697
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.67333991
5EZH2_22144423_ChIP-Seq_EOC_Human3.42913243
6TAF15_26573619_Chip-Seq_HEK293_Human3.36187937
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.19882073
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95207196
9ELK1_19687146_ChIP-ChIP_HELA_Human2.92975559
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80424381
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74235600
12E2F7_22180533_ChIP-Seq_HELA_Human2.67144100
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64299664
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.59988926
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.59823473
16* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58316789
17* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52360545
18VDR_23849224_ChIP-Seq_CD4+_Human2.45127439
19* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41574942
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33148962
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24469854
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18211574
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16483507
24* P300_19829295_ChIP-Seq_ESCs_Human2.13206532
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.10044438
26FOXP3_21729870_ChIP-Seq_TREG_Human2.06564680
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06438680
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06002689
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05534396
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02299331
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01591854
32* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99679181
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95747349
34ZNF274_21170338_ChIP-Seq_K562_Hela1.94962120
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92062345
36MYC_18940864_ChIP-ChIP_HL60_Human1.91154645
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87127010
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.84126121
39VDR_22108803_ChIP-Seq_LS180_Human1.84102357
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83459876
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83321405
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.83043037
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82551535
44* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82105499
45SMAD4_21799915_ChIP-Seq_A2780_Human1.80670513
46* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76758880
47FUS_26573619_Chip-Seq_HEK293_Human1.75362921
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75259490
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73501536
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70537591
51DCP1A_22483619_ChIP-Seq_HELA_Human1.69432016
52* ER_23166858_ChIP-Seq_MCF-7_Human1.67889623
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.67831069
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64179095
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.62359306
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60865339
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60363123
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59898353
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.58198902
60* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56348612
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.56319185
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.56150268
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.55864193
64P53_22387025_ChIP-Seq_ESCs_Mouse1.55833046
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.53533791
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.53086436
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52905772
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52394428
69TTF2_22483619_ChIP-Seq_HELA_Human1.52211216
70EWS_26573619_Chip-Seq_HEK293_Human1.51864174
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51586049
72* REST_21632747_ChIP-Seq_MESCs_Mouse1.50637598
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.50328299
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49780614
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48881882
76* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48821768
77* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47531841
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.47076946
79* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46740761
80* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46328673
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45737198
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45144803
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.44780947
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43816432
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.43336323
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43056283
87* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41444864
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41077201
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41077201
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.39448385
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38936765
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38756020
93P300_18555785_Chip-Seq_ESCs_Mouse1.37103067
94RUNX1_27457419_Chip-Seq_LIVER_Mouse1.36919917
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.36345611
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36223612
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.35060592
98* AR_25329375_ChIP-Seq_VCAP_Human1.34859373
99NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33676947
100* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32629925
101NMYC_18555785_Chip-Seq_ESCs_Mouse1.32583476
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30937189
103GABP_19822575_ChIP-Seq_HepG2_Human1.30585785
104* RNF2_27304074_Chip-Seq_NSC_Mouse1.30481525
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29536487
106* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29417801
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28922244
108MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27950880
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26342498
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26155446
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25901027
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24226936
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23315177
114* TAL1_26923725_Chip-Seq_HPCs_Mouse1.23274051
115EZH2_27294783_Chip-Seq_ESCs_Mouse1.23179450
116* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22896769
117HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20866313
118JUN_21703547_ChIP-Seq_K562_Human1.20620172
119ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20130052
120AR_21909140_ChIP-Seq_LNCAP_Human1.20075201
121AR_21572438_ChIP-Seq_LNCaP_Human1.19505270
122NANOG_16153702_ChIP-ChIP_HESCs_Human1.19492337
123HTT_18923047_ChIP-ChIP_STHdh_Human1.19260774
124OCT4_18555785_Chip-Seq_ESCs_Mouse1.19076807
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19017167
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18981773
127MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18715694
128ZFX_18555785_Chip-Seq_ESCs_Mouse1.16856711
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16004374
130* KDM2B_26808549_Chip-Seq_REH_Human1.16003061
131* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15574252
132PU1_27457419_Chip-Seq_LIVER_Mouse1.15509044
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14488278
134BP1_19119308_ChIP-ChIP_Hs578T_Human1.14386556
135REST_18959480_ChIP-ChIP_MESCs_Mouse1.14021201
136* IGF1R_20145208_ChIP-Seq_DFB_Human1.13503339
137SRF_21415370_ChIP-Seq_HL-1_Mouse1.13374960
138CTCF_18555785_Chip-Seq_ESCs_Mouse1.13262328
139KLF4_18555785_Chip-Seq_ESCs_Mouse1.13048724
140SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12969064
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11268790
142RUNX2_22187159_ChIP-Seq_PCA_Human1.11211281
143CRX_20693478_ChIP-Seq_RETINA_Mouse1.10585265
144SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10119369
145NANOG_19829295_ChIP-Seq_ESCs_Human1.09539002
146SOX2_19829295_ChIP-Seq_ESCs_Human1.09539002
147SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08836416
148TCF4_23295773_ChIP-Seq_U87_Human1.08241657
149EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08014935
150* E2F1_21310950_ChIP-Seq_MCF-7_Human1.07650663
151TP53_22573176_ChIP-Seq_HFKS_Human1.07620346
152TP53_18474530_ChIP-ChIP_U2OS_Human1.07303887
153* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07274263
154* PRDM14_20953172_ChIP-Seq_ESCs_Human1.06113031
155ELK1_22589737_ChIP-Seq_MCF10A_Human1.02481672
156GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02023234
157SOX2_16153702_ChIP-ChIP_HESCs_Human1.01105209
158FOXM1_23109430_ChIP-Seq_U2OS_Human0.99157088
159XRN2_22483619_ChIP-Seq_HELA_Human0.97630647
160YY1_21170310_ChIP-Seq_MESCs_Mouse0.97295361
161POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95890344
162DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95166269
163CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94610278
164KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91614357
165FOXA1_25329375_ChIP-Seq_VCAP_Human0.90531089
166FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90531089
167IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88288791
168CBP_20019798_ChIP-Seq_JUKART_Human0.88288791
169AR_20517297_ChIP-Seq_VCAP_Human0.82861538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.87707545
2MP0008058_abnormal_DNA_repair3.76568705
3MP0010094_abnormal_chromosome_stability3.13360231
4MP0006276_abnormal_autonomic_nervous2.89494458
5MP0002736_abnormal_nociception_after2.81863908
6MP0009046_muscle_twitch2.81781720
7MP0004957_abnormal_blastocyst_morpholog2.81648822
8MP0003693_abnormal_embryo_hatching2.81345102
9MP0008057_abnormal_DNA_replication2.80940582
10MP0002876_abnormal_thyroid_physiology2.80409366
11MP0006072_abnormal_retinal_apoptosis2.78289334
12MP0001529_abnormal_vocalization2.77389318
13MP0001188_hyperpigmentation2.65787698
14MP0001968_abnormal_touch/_nociception2.62433639
15MP0009745_abnormal_behavioral_response2.56018932
16MP0002735_abnormal_chemical_nociception2.53685356
17MP0005646_abnormal_pituitary_gland2.53460553
18MP0009697_abnormal_copulation2.48842456
19MP0002064_seizures2.39126190
20MP0003786_premature_aging2.35723551
21MP0004147_increased_porphyrin_level2.34895917
22MP0005645_abnormal_hypothalamus_physiol2.34803503
23MP0001986_abnormal_taste_sensitivity2.31856540
24MP0004859_abnormal_synaptic_plasticity2.25686026
25MP0003635_abnormal_synaptic_transmissio2.21110934
26MP0002272_abnormal_nervous_system2.20105666
27MP0003123_paternal_imprinting2.16509174
28MP0001905_abnormal_dopamine_level2.13882766
29MP0003787_abnormal_imprinting2.08892470
30MP0002572_abnormal_emotion/affect_behav2.05051118
31MP0003195_calcinosis2.00689136
32MP0005171_absent_coat_pigmentation2.00073105
33MP0003186_abnormal_redox_activity1.98957097
34MP0003111_abnormal_nucleus_morphology1.97929074
35MP0002822_catalepsy1.97313649
36MP0002102_abnormal_ear_morphology1.96906459
37MP0003718_maternal_effect1.94423231
38MP0003941_abnormal_skin_development1.92053606
39MP0001984_abnormal_olfaction1.91530634
40MP0002163_abnormal_gland_morphology1.87479148
41MP0001486_abnormal_startle_reflex1.86179175
42MP0002734_abnormal_mechanical_nocicepti1.86151255
43MP0004142_abnormal_muscle_tone1.85162316
44MP0002063_abnormal_learning/memory/cond1.84460801
45MP0003122_maternal_imprinting1.82757570
46MP0008007_abnormal_cellular_replicative1.82649517
47MP0003806_abnormal_nucleotide_metabolis1.80094188
48MP0002837_dystrophic_cardiac_calcinosis1.74840034
49MP0001501_abnormal_sleep_pattern1.74118867
50MP0002067_abnormal_sensory_capabilities1.73115458
51MP0003646_muscle_fatigue1.72151787
52MP0003890_abnormal_embryonic-extraembry1.70224213
53MP0002638_abnormal_pupillary_reflex1.69229781
54MP0008932_abnormal_embryonic_tissue1.65288954
55MP0003077_abnormal_cell_cycle1.63877472
56MP0004270_analgesia1.60469215
57MP0004043_abnormal_pH_regulation1.48535016
58MP0002254_reproductive_system_inflammat1.48500555
59MP0010386_abnormal_urinary_bladder1.45943619
60MP0008260_abnormal_autophagy1.45379974
61MP0003121_genomic_imprinting1.43647107
62MP0002090_abnormal_vision1.41736371
63MP0001485_abnormal_pinna_reflex1.39594357
64MP0001970_abnormal_pain_threshold1.39507301
65MP0001440_abnormal_grooming_behavior1.38376465
66MP0003567_abnormal_fetal_cardiomyocyte1.37087743
67MP0006292_abnormal_olfactory_placode1.34414157
68MP0004924_abnormal_behavior1.34153390
69MP0005386_behavior/neurological_phenoty1.34153390
70MP0005423_abnormal_somatic_nervous1.33607052
71MP0002557_abnormal_social/conspecific_i1.32979542
72MP0009379_abnormal_foot_pigmentation1.31604943
73MP0003183_abnormal_peptide_metabolism1.31179581
74MP0001293_anophthalmia1.28915265
75MP0005551_abnormal_eye_electrophysiolog1.27542654
76MP0000372_irregular_coat_pigmentation1.24370536
77MP0006036_abnormal_mitochondrial_physio1.24321577
78MP0000681_abnormal_thyroid_gland1.21761463
79MP0000516_abnormal_urinary_system1.21338565
80MP0005367_renal/urinary_system_phenotyp1.21338565
81MP0003879_abnormal_hair_cell1.19612015
82MP0005332_abnormal_amino_acid1.19042958
83MP0002160_abnormal_reproductive_system1.18793432
84MP0002733_abnormal_thermal_nociception1.15011091
85MP0006035_abnormal_mitochondrial_morpho1.14707383
86MP0005174_abnormal_tail_pigmentation1.13073709
87MP0002210_abnormal_sex_determination1.12445920
88MP0002184_abnormal_innervation1.09814950
89MP0005389_reproductive_system_phenotype1.09051623
90MP0005075_abnormal_melanosome_morpholog1.07518640
91MP0005084_abnormal_gallbladder_morpholo1.07436448
92MP0001929_abnormal_gametogenesis1.04585882
93MP0003136_yellow_coat_color1.04258287
94MP0004215_abnormal_myocardial_fiber1.03817999
95MP0008875_abnormal_xenobiotic_pharmacok1.02924778
96MP0001963_abnormal_hearing_physiology1.02235815
97MP0003937_abnormal_limbs/digits/tail_de0.99827188
98MP0001145_abnormal_male_reproductive0.99588383
99MP0000653_abnormal_sex_gland0.98885343
100MP0005503_abnormal_tendon_morphology0.98043877
101MP0003011_delayed_dark_adaptation0.97586420
102MP0000013_abnormal_adipose_tissue0.97118564
103MP0000751_myopathy0.96836664
104MP0000566_synostosis0.96351172
105MP0001764_abnormal_homeostasis0.95329032
106MP0004036_abnormal_muscle_relaxation0.94624855
107MP0008877_abnormal_DNA_methylation0.94071522
108MP0000647_abnormal_sebaceous_gland0.93214849
109MP0000427_abnormal_hair_cycle0.92553444
110MP0000749_muscle_degeneration0.92478352
111MP0008872_abnormal_physiological_respon0.92466079
112MP0002751_abnormal_autonomic_nervous0.92452117
113MP0000358_abnormal_cell_content/0.91130317
114MP0002938_white_spotting0.91035207
115MP0002277_abnormal_respiratory_mucosa0.90008682
116MP0001661_extended_life_span0.88532373
117MP0003283_abnormal_digestive_organ0.86998373
118MP0002066_abnormal_motor_capabilities/c0.86695865
119MP0010234_abnormal_vibrissa_follicle0.86515578
120MP0004133_heterotaxia0.86214848
121MP0003119_abnormal_digestive_system0.85354607
122MP0003137_abnormal_impulse_conducting0.84381558
123MP0001664_abnormal_digestion0.83560208
124MP0000015_abnormal_ear_pigmentation0.81020059
125MP0008995_early_reproductive_senescence0.79788384
126MP0000230_abnormal_systemic_arterial0.79465086
127MP0005220_abnormal_exocrine_pancreas0.78529032
128MP0002234_abnormal_pharynx_morphology0.77748284
129MP0008569_lethality_at_weaning0.77534390
130MP0005499_abnormal_olfactory_system0.77271528
131MP0005394_taste/olfaction_phenotype0.77271528
132MP0000778_abnormal_nervous_system0.76477885
133MP0004484_altered_response_of0.74454702
134MP0005636_abnormal_mineral_homeostasis0.73588926
135MP0002693_abnormal_pancreas_physiology0.73212343
136MP0001324_abnormal_eye_pigmentation0.72623040
137MP0004145_abnormal_muscle_electrophysio0.72201319
138MP0002229_neurodegeneration0.72186579
139MP0001177_atelectasis0.71943109
140MP0004085_abnormal_heartbeat0.70949012
141MP0003633_abnormal_nervous_system0.70848669
142MP0002882_abnormal_neuron_morphology0.70759292
143MP0003698_abnormal_male_reproductive0.70596334
144MP0002095_abnormal_skin_pigmentation0.69839555
145MP0001697_abnormal_embryo_size0.69383245
146MP0001502_abnormal_circadian_rhythm0.69009374
147MP0002233_abnormal_nose_morphology0.68182915
148MP0005408_hypopigmentation0.67737545
149MP0000631_abnormal_neuroendocrine_gland0.67724757
150MP0004782_abnormal_surfactant_physiolog0.67574295
151MP0005379_endocrine/exocrine_gland_phen0.67451252
152MP0005535_abnormal_body_temperature0.67359841
153MP0005409_darkened_coat_color0.66457419
154MP0005253_abnormal_eye_physiology0.65238481
155MP0000026_abnormal_inner_ear0.64679556
156MP0002009_preneoplasia0.63468406
157MP0008789_abnormal_olfactory_epithelium0.63353513
158MP0000538_abnormal_urinary_bladder0.63247230
159MP0002069_abnormal_eating/drinking_beha0.63074461
160MP0005365_abnormal_bile_salt0.61549036
161MP0001542_abnormal_bone_strength0.59793541

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.32582954
2Focal motor seizures (HP:0011153)5.26175501
3Abnormal mitochondria in muscle tissue (HP:0008316)5.13153073
4Mitochondrial inheritance (HP:0001427)4.79581371
5Progressive macrocephaly (HP:0004481)4.60380203
6Hypothermia (HP:0002045)4.51612642
7Acute encephalopathy (HP:0006846)4.44619994
8Febrile seizures (HP:0002373)4.37112500
9Hepatocellular necrosis (HP:0001404)4.35267819
10Increased CSF lactate (HP:0002490)4.23539340
11Hepatic necrosis (HP:0002605)3.87754251
12Hyperventilation (HP:0002883)3.78470530
13Abnormal hair whorl (HP:0010721)3.77440430
14Atonic seizures (HP:0010819)3.56767400
15Epileptic encephalopathy (HP:0200134)3.30197707
16Pheochromocytoma (HP:0002666)3.25006492
173-Methylglutaconic aciduria (HP:0003535)3.16546813
18Medial flaring of the eyebrow (HP:0010747)3.15055261
19Optic disc pallor (HP:0000543)3.09018856
20Cerebral edema (HP:0002181)3.08590630
21Lactic acidosis (HP:0003128)3.05177799
22Neuroendocrine neoplasm (HP:0100634)3.05123057
23Colon cancer (HP:0003003)3.03803688
24Increased hepatocellular lipid droplets (HP:0006565)2.99584555
25Abnormality of methionine metabolism (HP:0010901)2.96888161
26Abnormality of the labia minora (HP:0012880)2.90949580
27Renal Fanconi syndrome (HP:0001994)2.88460893
28Exercise intolerance (HP:0003546)2.83737805
29Increased intramyocellular lipid droplets (HP:0012240)2.81519706
30Abnormality of glycolysis (HP:0004366)2.79887099
31Increased serum pyruvate (HP:0003542)2.79887099
32Exertional dyspnea (HP:0002875)2.77396576
33Hyperinsulinemic hypoglycemia (HP:0000825)2.77057683
34Nephrogenic diabetes insipidus (HP:0009806)2.73111120
35Increased serum lactate (HP:0002151)2.72288049
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68433181
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68433181
38Congenital primary aphakia (HP:0007707)2.62935559
39Respiratory failure (HP:0002878)2.62916341
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62737184
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.62255734
42Lipid accumulation in hepatocytes (HP:0006561)2.61968846
43Congenital, generalized hypertrichosis (HP:0004540)2.61333909
44Gait imbalance (HP:0002141)2.56891581
45Focal seizures (HP:0007359)2.56556068
46Poor suck (HP:0002033)2.55826298
47Methylmalonic acidemia (HP:0002912)2.55410950
48Hyperglycinemia (HP:0002154)2.52820604
49Hypoglycemic coma (HP:0001325)2.51236128
50Leukodystrophy (HP:0002415)2.48024651
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46657740
52Ketoacidosis (HP:0001993)2.42946771
53Abnormality of vitamin B metabolism (HP:0004340)2.42877316
54Myokymia (HP:0002411)2.39790076
55Generalized tonic-clonic seizures (HP:0002069)2.37574301
56Pancreatic fibrosis (HP:0100732)2.37366829
57Oligomenorrhea (HP:0000876)2.34465736
58Hypoglycemic seizures (HP:0002173)2.31896706
59True hermaphroditism (HP:0010459)2.31684324
60Pancreatic cysts (HP:0001737)2.28814492
61Abnormality of alanine metabolism (HP:0010916)2.28439565
62Hyperalaninemia (HP:0003348)2.28439565
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28439565
64Increased muscle lipid content (HP:0009058)2.28159842
65Polyphagia (HP:0002591)2.26430281
66Abnormality of chromosome stability (HP:0003220)2.26315857
67Abnormal protein glycosylation (HP:0012346)2.26302547
68Abnormal glycosylation (HP:0012345)2.26302547
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26302547
70Abnormal protein N-linked glycosylation (HP:0012347)2.26302547
71Abnormality of serum amino acid levels (HP:0003112)2.26244440
72Chronic hepatic failure (HP:0100626)2.25268882
73Absence seizures (HP:0002121)2.24747515
74Abnormality of the vitamin B12 metabolism (HP:0004341)2.23839630
75Megaloblastic anemia (HP:0001889)2.23031021
76Dialeptic seizures (HP:0011146)2.21252755
77Fair hair (HP:0002286)2.19483038
78Poor coordination (HP:0002370)2.18600634
79Intestinal atresia (HP:0011100)2.16728047
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.15948270
81Reduced antithrombin III activity (HP:0001976)2.13878900
82Genital tract atresia (HP:0001827)2.13342701
83Meckel diverticulum (HP:0002245)2.13336130
84Molar tooth sign on MRI (HP:0002419)2.11719120
85Abnormality of midbrain morphology (HP:0002418)2.11719120
86Long foot (HP:0001833)2.09668161
87Fetal akinesia sequence (HP:0001989)2.07407303
88Abnormality of urine glucose concentration (HP:0011016)2.06991741
89Glycosuria (HP:0003076)2.06991741
90Progressive cerebellar ataxia (HP:0002073)2.05933747
91Pancreatic islet-cell hyperplasia (HP:0004510)2.04630272
92Abnormality of the ileum (HP:0001549)2.03155453
93Methylmalonic aciduria (HP:0012120)2.02944877
94Abnormality of the preputium (HP:0100587)2.01120045
95Chromsome breakage (HP:0040012)2.00680463
96Vaginal atresia (HP:0000148)2.00516030
97Broad-based gait (HP:0002136)2.00464163
98Patchy hypopigmentation of hair (HP:0011365)1.99849122
99Macrocytic anemia (HP:0001972)1.98742706
100Abnormality of renal resorption (HP:0011038)1.98044209
101Microvesicular hepatic steatosis (HP:0001414)1.97390226
102Aplastic anemia (HP:0001915)1.95619412
103Abnormality of the anterior horn cell (HP:0006802)1.94246129
104Degeneration of anterior horn cells (HP:0002398)1.94246129
105Nephronophthisis (HP:0000090)1.93684427
106Gaze-evoked nystagmus (HP:0000640)1.92218415
107Volvulus (HP:0002580)1.91641474
108Type I transferrin isoform profile (HP:0003642)1.91517530
109Respiratory difficulties (HP:0002880)1.91508027
110Protruding tongue (HP:0010808)1.91416436
111Hypomagnesemia (HP:0002917)1.90703850
112Esophageal neoplasm (HP:0100751)1.90161847
113Neoplasm of head and neck (HP:0012288)1.90161847
114Palpitations (HP:0001962)1.89863827
115Renal cortical cysts (HP:0000803)1.87388758
116Abnormal lung lobation (HP:0002101)1.87356666
117Abnormality of the renal cortex (HP:0011035)1.87005976
118Abnormal number of erythroid precursors (HP:0012131)1.86778335
119White forelock (HP:0002211)1.86387329
120X-linked dominant inheritance (HP:0001423)1.86168639
121Thyroid-stimulating hormone excess (HP:0002925)1.85782887
122Generalized hypopigmentation of hair (HP:0011358)1.85503806
123Esotropia (HP:0000565)1.84444280
124Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84154694
125Parakeratosis (HP:0001036)1.84144204
126Limb dystonia (HP:0002451)1.83769360
127Conjugated hyperbilirubinemia (HP:0002908)1.83688097
128Inability to walk (HP:0002540)1.83687063
129Abnormality of homocysteine metabolism (HP:0010919)1.83210725
130Homocystinuria (HP:0002156)1.83210725
131Abnormality of serine family amino acid metabolism (HP:0010894)1.82238407
132Abnormality of glycine metabolism (HP:0010895)1.82238407
133Symptomatic seizures (HP:0011145)1.82015733
134Blue irides (HP:0000635)1.80128952
135Neoplasm of the adrenal gland (HP:0100631)1.78508181
136Hyperphosphaturia (HP:0003109)1.76832537
137Ketosis (HP:0001946)1.76749695
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.75432417
139CNS demyelination (HP:0007305)1.75403941
140Pancytopenia (HP:0001876)1.75342246
141Abnormality of the pons (HP:0007361)1.74472744
142Abnormality of incisor morphology (HP:0011063)1.73131863
143Abolished electroretinogram (ERG) (HP:0000550)1.72606390
144Abnormality of the pancreatic islet cells (HP:0006476)1.72581093
145Abnormality of endocrine pancreas physiology (HP:0012093)1.72581093
146Epileptiform EEG discharges (HP:0011182)1.71314618
147Renal tubular dysfunction (HP:0000124)1.71194111
148Birth length less than 3rd percentile (HP:0003561)1.70937746
149Abnormal eating behavior (HP:0100738)1.70101241
150Lethargy (HP:0001254)1.69717383
151Anxiety (HP:0000739)1.66897936
152Calf muscle hypertrophy (HP:0008981)1.65121394
153Muscle hypertrophy of the lower extremities (HP:0008968)1.64465338
154Cholecystitis (HP:0001082)1.58601115
155Abnormal gallbladder physiology (HP:0012438)1.58601115
156Progressive external ophthalmoplegia (HP:0000590)1.57705260
157Metaphyseal dysplasia (HP:0100255)1.57544927
158Progressive inability to walk (HP:0002505)1.57312582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.60970757
2CASK4.44013286
3SIK33.63173201
4BUB13.19820698
5VRK23.18632424
6MAP2K72.98799583
7STK162.79411169
8TRIM282.65471237
9NUAK12.51393661
10NTRK32.46084948
11TNIK2.42741267
12NEK12.39987482
13CDK192.19878150
14PLK32.18304663
15PRPF4B2.16313742
16MYLK2.13622054
17SRPK12.02678159
18PBK2.02670505
19CDC72.00529494
20MAP4K21.97938506
21MAP3K41.96404525
22EIF2AK11.92046719
23INSRR1.91974196
24PLK41.89292229
25TTK1.88581486
26TAF11.86774406
27OXSR11.86566925
28MKNK11.86163181
29BMPR21.84759003
30GRK71.83082242
31BRSK21.82541050
32AKT31.79607067
33PLK21.63558132
34EPHA41.62951217
35ADRBK21.62280551
36ACVR1B1.59155543
37WEE11.49877091
38SGK21.47252557
39BCR1.44904846
40ERBB31.38795435
41MAP2K41.38173975
42CCNB11.34318549
43BMPR1B1.30428688
44TNK21.25903325
45SGK2231.23263320
46SGK4941.23263320
47STK38L1.22481139
48MAPK131.21736432
49PLK11.20524714
50MUSK1.19722307
51TSSK61.13720913
52PINK11.12363686
53WNK31.12308029
54DAPK11.09446234
55CDK81.09254925
56TXK1.05770881
57YES11.05649542
58PASK1.05586709
59CSNK1G11.04757691
60ZAK1.02564186
61PNCK1.01395360
62CAMKK20.98098676
63NME10.97907690
64MINK10.97435062
65CSNK1G20.96746224
66ARAF0.95768037
67GRK50.94362889
68CSNK1G30.91809412
69STK30.90967662
70OBSCN0.90782229
71NEK60.89782593
72FGFR20.87815793
73CAMK2B0.87557918
74VRK10.84342731
75PRKCE0.84181652
76CAMK2A0.83680616
77PRKCG0.77523613
78NLK0.77112467
79DYRK20.74457540
80NME20.71936067
81BRSK10.71383645
82STK240.67558767
83CAMK2D0.67190345
84WNK40.64770330
85ATR0.64635375
86MAP3K140.64572814
87CSNK1A1L0.61148873
88CAMK2G0.61051642
89SGK30.60849503
90IRAK40.60302033
91AURKB0.60209753
92RIPK40.59459180
93STK390.58545259
94LIMK10.58376652
95TEC0.57674759
96STK40.57432109
97BRAF0.56988719
98ADRBK10.56979544
99EIF2AK30.56959705
100ATM0.56092478
101TLK10.55725982
102TGFBR10.54728836
103MST40.54248389
104CHEK20.54232994
105MKNK20.53933301
106GRK10.52484696
107ALK0.52368891
108EIF2AK20.52262327
109PDK20.51710267
110IRAK30.51326034
111RPS6KA40.51130132
112KIT0.50481223
113DYRK1A0.48692020
114RPS6KB10.47780322
115CSNK2A20.47376966
116CSNK2A10.47194155
117MARK10.46407508
118PRKG20.46269154
119DAPK20.46117005
120CDK50.45522768
121PIK3CA0.44147770
122MAPK70.43603326
123PRKACA0.43453487
124CDK30.42976292
125MAP2K60.42484970
126FRK0.42395286
127TAOK20.42280411
128MAPKAPK50.42182316
129IRAK10.41631324
130DYRK30.38834274
131NTRK20.38445996
132BCKDK0.38206989
133SGK10.37612272
134TIE10.37611950
135PAK30.37558837
136FER0.37528870
137CSNK1E0.36817843
138PRKG10.35887121
139CSNK1A10.35548100
140ERBB40.33855229
141SYK0.32187999
142CAMK10.31606012
143FES0.31265778
144LATS10.31250551
145PRKCA0.31244396
146PHKG10.30641493
147PHKG20.30641493
148PRKCQ0.30494672
149RPS6KA50.29854195
150FGFR10.29450085
151IRAK20.29020518
152MAP3K130.28564861
153PTK2B0.28521852
154CHEK10.27058809
155PRKCI0.25508049
156KDR0.22825651

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.57339806
2Parkinsons disease_Homo sapiens_hsa050123.51887642
3Collecting duct acid secretion_Homo sapiens_hsa049663.46058259
4Nicotine addiction_Homo sapiens_hsa050333.23579604
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.00878268
6Synaptic vesicle cycle_Homo sapiens_hsa047212.85733594
7Alzheimers disease_Homo sapiens_hsa050102.75150815
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.64833470
9Mismatch repair_Homo sapiens_hsa034302.57682534
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54767394
11Non-homologous end-joining_Homo sapiens_hsa034502.45608632
12Ribosome_Homo sapiens_hsa030102.44087404
13Homologous recombination_Homo sapiens_hsa034402.38542437
14Huntingtons disease_Homo sapiens_hsa050162.37635222
15DNA replication_Homo sapiens_hsa030302.22484502
16Fatty acid elongation_Homo sapiens_hsa000622.14765066
17Protein export_Homo sapiens_hsa030602.05356714
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97948799
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95123067
20Vibrio cholerae infection_Homo sapiens_hsa051101.93948963
21Basal transcription factors_Homo sapiens_hsa030221.93254676
22RNA degradation_Homo sapiens_hsa030181.81675048
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75331399
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74375419
25Rheumatoid arthritis_Homo sapiens_hsa053231.74341010
26GABAergic synapse_Homo sapiens_hsa047271.74292681
27Morphine addiction_Homo sapiens_hsa050321.73218450
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73076099
29Fanconi anemia pathway_Homo sapiens_hsa034601.72341209
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71644958
31One carbon pool by folate_Homo sapiens_hsa006701.71315732
32Nucleotide excision repair_Homo sapiens_hsa034201.69114900
33Proteasome_Homo sapiens_hsa030501.67738184
34Phototransduction_Homo sapiens_hsa047441.66184039
35RNA transport_Homo sapiens_hsa030131.66032258
36Propanoate metabolism_Homo sapiens_hsa006401.64206342
37Olfactory transduction_Homo sapiens_hsa047401.63459715
38Spliceosome_Homo sapiens_hsa030401.59042614
39Taste transduction_Homo sapiens_hsa047421.54848757
40Cardiac muscle contraction_Homo sapiens_hsa042601.54662679
41Pyruvate metabolism_Homo sapiens_hsa006201.49599081
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45509366
43Serotonergic synapse_Homo sapiens_hsa047261.45473239
44Circadian entrainment_Homo sapiens_hsa047131.43909452
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.42661048
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.41347445
47Pyrimidine metabolism_Homo sapiens_hsa002401.39101414
48Base excision repair_Homo sapiens_hsa034101.32334946
49Butanoate metabolism_Homo sapiens_hsa006501.25490248
50Selenocompound metabolism_Homo sapiens_hsa004501.23085602
51Glutamatergic synapse_Homo sapiens_hsa047241.22070459
52Amphetamine addiction_Homo sapiens_hsa050311.11117426
53Folate biosynthesis_Homo sapiens_hsa007901.09601982
54Sulfur metabolism_Homo sapiens_hsa009201.08820761
55Phagosome_Homo sapiens_hsa041451.04413503
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04097842
57Glutathione metabolism_Homo sapiens_hsa004801.02181842
58Calcium signaling pathway_Homo sapiens_hsa040201.01975760
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01792065
60Peroxisome_Homo sapiens_hsa041460.99951593
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97039673
62Cell cycle_Homo sapiens_hsa041100.95662034
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95202157
64Dopaminergic synapse_Homo sapiens_hsa047280.95045883
65Regulation of autophagy_Homo sapiens_hsa041400.89742674
66Insulin secretion_Homo sapiens_hsa049110.89246058
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89015062
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88985069
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.83559804
70Tryptophan metabolism_Homo sapiens_hsa003800.82864331
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80187890
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77604430
73Nitrogen metabolism_Homo sapiens_hsa009100.77415224
74Metabolic pathways_Homo sapiens_hsa011000.73326720
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72747818
76Oocyte meiosis_Homo sapiens_hsa041140.72681993
77Salivary secretion_Homo sapiens_hsa049700.72234055
78Long-term depression_Homo sapiens_hsa047300.71613822
79Long-term potentiation_Homo sapiens_hsa047200.70908123
80Type I diabetes mellitus_Homo sapiens_hsa049400.69849774
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68642638
82beta-Alanine metabolism_Homo sapiens_hsa004100.68290835
83Cholinergic synapse_Homo sapiens_hsa047250.68046617
84Cocaine addiction_Homo sapiens_hsa050300.67093357
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66662776
86Renin secretion_Homo sapiens_hsa049240.63501383
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62968807
88N-Glycan biosynthesis_Homo sapiens_hsa005100.61321061
89Tyrosine metabolism_Homo sapiens_hsa003500.60191912
90Vitamin B6 metabolism_Homo sapiens_hsa007500.59986178
91Histidine metabolism_Homo sapiens_hsa003400.59848608
92Phenylalanine metabolism_Homo sapiens_hsa003600.58174506
93Caffeine metabolism_Homo sapiens_hsa002320.58134230
94Fatty acid degradation_Homo sapiens_hsa000710.57432811
95p53 signaling pathway_Homo sapiens_hsa041150.57277721
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56828544
97RNA polymerase_Homo sapiens_hsa030200.55943686
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54840853
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52388370
100Autoimmune thyroid disease_Homo sapiens_hsa053200.51488887
101Chemical carcinogenesis_Homo sapiens_hsa052040.51443223
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51302347
103Carbon metabolism_Homo sapiens_hsa012000.50359080
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50263844
105Purine metabolism_Homo sapiens_hsa002300.49131246
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47721088
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47406726
108Sphingolipid metabolism_Homo sapiens_hsa006000.46524480
109Starch and sucrose metabolism_Homo sapiens_hsa005000.45596344
110Fatty acid metabolism_Homo sapiens_hsa012120.44482094
111Arachidonic acid metabolism_Homo sapiens_hsa005900.43778614
112mRNA surveillance pathway_Homo sapiens_hsa030150.43452847
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41603288
114Steroid biosynthesis_Homo sapiens_hsa001000.40204307
115Linoleic acid metabolism_Homo sapiens_hsa005910.39928333
116Retinol metabolism_Homo sapiens_hsa008300.38687935
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38162998
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38106416
119Ether lipid metabolism_Homo sapiens_hsa005650.37389163
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.36106859
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32867879
122Gastric acid secretion_Homo sapiens_hsa049710.30220971
123Oxytocin signaling pathway_Homo sapiens_hsa049210.30123955
124Circadian rhythm_Homo sapiens_hsa047100.29410318
125Fructose and mannose metabolism_Homo sapiens_hsa000510.29049779
126Other glycan degradation_Homo sapiens_hsa005110.28709489
127African trypanosomiasis_Homo sapiens_hsa051430.27791617
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27397553
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26627133
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26306265
131Vitamin digestion and absorption_Homo sapiens_hsa049770.26010751
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.25700837
133Arginine and proline metabolism_Homo sapiens_hsa003300.25283511
134Mineral absorption_Homo sapiens_hsa049780.24736474
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.24412282
136Biosynthesis of amino acids_Homo sapiens_hsa012300.23828161
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.22820016
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.22198401
139cAMP signaling pathway_Homo sapiens_hsa040240.22034738
140Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21969183
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20357916
142Fat digestion and absorption_Homo sapiens_hsa049750.20318930
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19042880
144TGF-beta signaling pathway_Homo sapiens_hsa043500.15697594
145Sulfur relay system_Homo sapiens_hsa041220.15022192
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14752919

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