TMEM114

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycosylated transmembrane protein that plays a role in lens and eye development. Mutations in this gene, including a t(16;22)(p13.3;q11.2) translocation, are associated with congenital and juvenile cataract disorders. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of male gonad development (GO:2000018)9.51096261
2piRNA metabolic process (GO:0034587)9.35790851
3regulation of meiosis I (GO:0060631)9.28529182
4sex differentiation (GO:0007548)7.51241923
5male sex determination (GO:0030238)7.19176077
6keratan sulfate catabolic process (GO:0042340)7.15399632
7fusion of sperm to egg plasma membrane (GO:0007342)6.70092435
8mesenchymal-epithelial cell signaling (GO:0060638)6.51513518
9synaptonemal complex assembly (GO:0007130)6.48356775
10otic vesicle formation (GO:0030916)6.44977579
11DNA methylation involved in gamete generation (GO:0043046)6.41879832
12male meiosis (GO:0007140)6.40527191
13positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr6.39525060
14synaptonemal complex organization (GO:0070193)6.20627455
15regulation of gonadotropin secretion (GO:0032276)6.17083717
16regulation of branching involved in salivary gland morphogenesis (GO:0060693)6.10217342
17oocyte development (GO:0048599)5.78988388
18skeletal muscle adaptation (GO:0043501)5.71742330
19poly(A)+ mRNA export from nucleus (GO:0016973)5.68487868
20radial glial cell differentiation (GO:0060019)5.64493759
21negative regulation of stress fiber assembly (GO:0051497)5.62300660
22camera-type eye morphogenesis (GO:0048593)5.61117474
23glycosphingolipid catabolic process (GO:0046479)5.58340965
24embryonic camera-type eye development (GO:0031076)5.50590756
25oligosaccharide catabolic process (GO:0009313)5.47501644
26anatomical structure regression (GO:0060033)5.47069311
27lateral sprouting from an epithelium (GO:0060601)5.45255656
28positive regulation of meiosis (GO:0045836)5.44639985
29plasma membrane fusion (GO:0045026)5.36936164
30regulation of female gonad development (GO:2000194)5.33734070
31positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)5.30880928
32regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 5.28938271
33negative regulation of meiosis (GO:0045835)5.13572799
34glomerular basement membrane development (GO:0032836)5.13177334
35response to misfolded protein (GO:0051788)5.03974311
36regulation of mitochondrial depolarization (GO:0051900)5.02205217
37ovulation cycle (GO:0042698)5.01674060
38positive regulation of meiotic cell cycle (GO:0051446)5.00610414
39glycolipid catabolic process (GO:0019377)4.99607548
40positive regulation of bone remodeling (GO:0046852)4.96026686
41positive regulation of bone resorption (GO:0045780)4.96026686
42negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.85579553
43cornea development in camera-type eye (GO:0061303)4.55971633
44amino sugar catabolic process (GO:0046348)4.47462617
45positive regulation of reproductive process (GO:2000243)4.46201015
46macroautophagy (GO:0016236)4.41793237
47muscle cell fate commitment (GO:0042693)4.41439845
48ceramide catabolic process (GO:0046514)4.40948735
49lung epithelium development (GO:0060428)4.38295122
50collagen catabolic process (GO:0030574)4.37538071
51cell migration involved in heart development (GO:0060973)4.37085165
52negative regulation of Rho protein signal transduction (GO:0035024)4.28184898
53astrocyte development (GO:0014002)4.28043787
54organ growth (GO:0035265)4.24423409
55fat-soluble vitamin biosynthetic process (GO:0042362)4.20251121
56negative regulation of actin filament bundle assembly (GO:0032232)4.18197419
57negative regulation of macrophage differentiation (GO:0045650)4.14726688
58venous blood vessel morphogenesis (GO:0048845)4.13131989
59adrenergic receptor signaling pathway (GO:0071875)4.06990903
60collagen metabolic process (GO:0032963)4.02646299
61multicellular organismal catabolic process (GO:0044243)3.99442732
62male meiosis I (GO:0007141)3.97681618
63Leydig cell differentiation (GO:0033327)3.96644575
64glial cell proliferation (GO:0014009)3.96602854
65eosinophil chemotaxis (GO:0048245)3.93255126
66meiotic nuclear division (GO:0007126)3.92796799
67chromosome organization involved in meiosis (GO:0070192)3.75874915
68multicellular organismal macromolecule metabolic process (GO:0044259)3.72083568
69glucosamine-containing compound catabolic process (GO:1901072)3.68672231
70female gamete generation (GO:0007292)3.67396080
71limb bud formation (GO:0060174)3.65794193
72positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.64581030
73multicellular organismal metabolic process (GO:0044236)3.55589276
74regulation of monocyte differentiation (GO:0045655)3.54381666
75neuronal ion channel clustering (GO:0045161)3.53907995
76hemoglobin metabolic process (GO:0020027)3.53691769
77gene silencing by RNA (GO:0031047)3.51295418
78sphingolipid catabolic process (GO:0030149)3.50693876
79branch elongation of an epithelium (GO:0060602)3.49395025
80protein localization to cell surface (GO:0034394)3.48750641
81drug transmembrane transport (GO:0006855)3.47548773
82regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.45862010
83eosinophil migration (GO:0072677)3.45315050
84myelination in peripheral nervous system (GO:0022011)3.43818499
85peripheral nervous system axon ensheathment (GO:0032292)3.43818499
86positive regulation of tissue remodeling (GO:0034105)3.43297228
87bicarbonate transport (GO:0015701)3.41956719
88membrane lipid catabolic process (GO:0046466)3.40267852
89histone H4-K8 acetylation (GO:0043982)3.40128056
90histone H4-K5 acetylation (GO:0043981)3.40128056
91receptor guanylyl cyclase signaling pathway (GO:0007168)3.40000073
92regulation of meiosis (GO:0040020)3.38487395
93induction of positive chemotaxis (GO:0050930)3.36334392
94regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.35273516
95oogenesis (GO:0048477)3.34206189
96histone H4-K12 acetylation (GO:0043983)3.33954889
97positive regulation of osteoclast differentiation (GO:0045672)3.33439946
98positive regulation of cell junction assembly (GO:1901890)3.29628528
99positive regulation of focal adhesion assembly (GO:0051894)3.29628528
100DNA methylation (GO:0006306)3.26658124
101DNA alkylation (GO:0006305)3.26658124
102negative regulation of meiotic cell cycle (GO:0051447)3.25262210
103germ cell development (GO:0007281)3.24358495
104diaphragm development (GO:0060539)3.23852483
105myeloid dendritic cell differentiation (GO:0043011)3.19427963
106positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.17993840
107negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.17661291
108keratan sulfate metabolic process (GO:0042339)3.16982088
109embryonic digestive tract morphogenesis (GO:0048557)3.16105666
110positive regulation of adherens junction organization (GO:1903393)3.15834616
111embryonic foregut morphogenesis (GO:0048617)3.13568990
112regulation of cholesterol storage (GO:0010885)3.11828399
113decidualization (GO:0046697)3.11185063
114peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.11104832
115activation of Rac GTPase activity (GO:0032863)3.06506122
116osteoclast differentiation (GO:0030316)3.06278729
117syncytium formation by plasma membrane fusion (GO:0000768)3.04924198
118negative regulation of nitric oxide biosynthetic process (GO:0045019)3.03430286
119outer ear morphogenesis (GO:0042473)3.02331544
120negative regulation of systemic arterial blood pressure (GO:0003085)3.01577005
121germ cell migration (GO:0008354)3.01462558
122positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.00892029
123skeletal muscle organ development (GO:0060538)2.99251382
124meiosis I (GO:0007127)2.99044996
125branching involved in labyrinthine layer morphogenesis (GO:0060670)2.97909677
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97104349
127regulation of acrosome reaction (GO:0060046)2.96206300
128regulation of vitamin D biosynthetic process (GO:0060556)2.95346093
129genitalia morphogenesis (GO:0035112)2.95071348
130cellular process involved in reproduction in multicellular organism (GO:0022412)2.95024359
131adhesion of symbiont to host cell (GO:0044650)2.92644691
132virion attachment to host cell (GO:0019062)2.92644691
133white fat cell differentiation (GO:0050872)2.89972695
134barbed-end actin filament capping (GO:0051016)2.89841328
135morphogenesis of an epithelial fold (GO:0060571)2.89035458
136kidney morphogenesis (GO:0060993)2.88063098
137peptidyl-lysine dimethylation (GO:0018027)2.86910070
138positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.84772165
139relaxation of cardiac muscle (GO:0055119)2.84649403
140regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84358903
141regulation of mononuclear cell migration (GO:0071675)2.83462064
142negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.82986454
143histone H3-K36 demethylation (GO:0070544)2.82578113
144negative regulation of interleukin-12 production (GO:0032695)2.82502777
145negative regulation of cation channel activity (GO:2001258)2.81865422
146Sertoli cell development (GO:0060009)2.81437316
147T-helper 1 type immune response (GO:0042088)2.80872259
148apoptotic cell clearance (GO:0043277)2.80243554
149keratan sulfate biosynthetic process (GO:0018146)2.79713929
150membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.79702510
151mesonephros development (GO:0001823)2.79557436
152regulation of meiotic cell cycle (GO:0051445)2.77427724
153extracellular matrix disassembly (GO:0022617)2.76114791
154regulation of short-term neuronal synaptic plasticity (GO:0048172)2.75348830
155histone H4-K16 acetylation (GO:0043984)2.74394016
156metanephric mesenchyme development (GO:0072075)2.73594611
157monocyte chemotaxis (GO:0002548)2.73278674
158negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.73154151
159negative regulation of calcium ion transmembrane transport (GO:1903170)2.73154151
160cyclooxygenase pathway (GO:0019371)2.72570418
161layer formation in cerebral cortex (GO:0021819)2.72319028
162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.71197864
163histone H2A acetylation (GO:0043968)2.70821061
164eye morphogenesis (GO:0048592)2.70702693
165spermatid development (GO:0007286)2.70600423
166cellular response to gonadotropin stimulus (GO:0071371)2.69800373
167myeloid dendritic cell activation (GO:0001773)2.69287353
168axis elongation (GO:0003401)2.69139442
169keratinocyte proliferation (GO:0043616)2.68799652
170pinocytosis (GO:0006907)2.67824627
171cellular response to thyroid hormone stimulus (GO:0097067)2.66013740
172organ induction (GO:0001759)2.65623412
173positive regulation of response to oxidative stress (GO:1902884)2.64812456
174positive regulation of cellular response to oxidative stress (GO:1900409)2.64812456
175gene silencing (GO:0016458)2.63464879
176seminiferous tubule development (GO:0072520)2.62412698
177non-canonical Wnt signaling pathway (GO:0035567)2.60963340
178membrane repolarization (GO:0086009)2.60311818
179serotonin metabolic process (GO:0042428)2.60269765
180adhesion of symbiont to host (GO:0044406)2.58834185
181temperature homeostasis (GO:0001659)2.58821961
182positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.58749565
183regulation of synaptic transmission, dopaminergic (GO:0032225)2.56373900
184negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.56251839
185vitamin catabolic process (GO:0009111)2.55639471
186fat-soluble vitamin catabolic process (GO:0042363)2.55639471
187female gonad development (GO:0008585)2.55578982
188positive regulation of receptor biosynthetic process (GO:0010870)2.54704074
189synaptic vesicle docking involved in exocytosis (GO:0016081)2.53630259
190positive regulation of sodium ion transmembrane transport (GO:1902307)2.52425354
191ovulation cycle process (GO:0022602)2.51166970
192spermatogenesis (GO:0007283)2.49334599
193regulation of nucleobase-containing compound transport (GO:0032239)2.48538534
194gonadal mesoderm development (GO:0007506)14.5366455
195positive regulation of male gonad development (GO:2000020)10.8505679
196sex determination (GO:0007530)10.2963465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human6.33744127
2IKZF1_21737484_ChIP-ChIP_HCT116_Human4.70071488
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.73000454
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.34806799
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.23290375
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.13319534
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.11419560
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.90391932
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.85876542
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.77781237
11EGR1_19032775_ChIP-ChIP_M12_Human2.66468807
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.52825147
13EZH2_22144423_ChIP-Seq_EOC_Human2.52667019
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.47328230
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.35436780
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33345342
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22704459
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21901161
19LXR_22292898_ChIP-Seq_THP-1_Human2.16017487
20IGF1R_20145208_ChIP-Seq_DFB_Human2.12304260
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07821823
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06778445
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99181769
24* RNF2_27304074_Chip-Seq_NSC_Mouse1.98912316
25* RNF2_27304074_Chip-Seq_ESCs_Mouse1.96849443
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.92511831
27TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.89254393
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87760372
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83794400
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83130661
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80011749
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.79967620
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.78990652
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77882330
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77882330
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77882330
37KDM2B_26808549_Chip-Seq_K562_Human1.77071322
38STAT1_20625510_ChIP-Seq_HELA_Human1.76193693
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76175055
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.75441322
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75426732
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75314552
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73273539
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70508009
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70508009
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70203719
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.66398675
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.64332116
49ZNF263_19887448_ChIP-Seq_K562_Human1.62281420
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61273647
51VDR_21846776_ChIP-Seq_THP-1_Human1.58713728
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56970098
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56905951
54* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56623026
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.56008058
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.55276375
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54945198
58STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.54897144
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.54370996
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53483950
61VDR_24787735_ChIP-Seq_THP-1_Human1.51878849
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.50490283
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.50087907
64DROSHA_22980978_ChIP-Seq_HELA_Human1.47278052
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46816069
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46234334
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41323840
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39928153
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38684615
70* SA1_27219007_Chip-Seq_ERYTHROID_Human1.38543933
71GBX2_23144817_ChIP-Seq_PC3_Human1.37339563
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37269368
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34750763
74KDM2B_26808549_Chip-Seq_DND41_Human1.34323703
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33296314
76* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31230169
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28375040
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26658471
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.25947946
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25927817
81ZNF274_21170338_ChIP-Seq_K562_Hela1.25274099
82ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24026759
83* CBX2_27304074_Chip-Seq_ESCs_Mouse1.22518549
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22513783
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20317399
86TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20273957
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19497339
88OCT4_19829295_ChIP-Seq_ESCs_Human1.19165368
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18948640
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.18869145
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18314471
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18023554
93SCL_19346495_ChIP-Seq_HPC-7_Human1.17632476
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17461261
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17145851
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.16742664
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15443515
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15416830
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.14229329
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14143106
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13903199
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.13222846
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12823601
104TCF7_22412390_ChIP-Seq_EML_Mouse1.12641851
105CLOCK_20551151_ChIP-Seq_293T_Human1.12341123
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.11914995
107* CREB1_26743006_Chip-Seq_LNCaP_Human1.11436130
108MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10615505
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10059995
110SMC4_20622854_ChIP-Seq_HELA_Human1.09494745
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09026953
112SPI1_23127762_ChIP-Seq_K562_Human1.08382493
113SA1_27219007_Chip-Seq_Bcells_Human1.08011628
114KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07440972
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07243753
116* STAT3_23295773_ChIP-Seq_U87_Human1.06946225
117* CTCF_27219007_Chip-Seq_Bcells_Human1.04326519
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03851772
119SMAD3_21741376_ChIP-Seq_ESCs_Human1.03691469
120* RING1B_27294783_Chip-Seq_ESCs_Mouse1.03286436
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03073264
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02672830
123SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02098665
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01955039
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01070524
126CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00735401
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99679280
128REST_18959480_ChIP-ChIP_MESCs_Mouse0.99237257
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98407250
130MAF_26560356_Chip-Seq_TH1_Human0.97963006
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96337527
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95700125
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95033897
134DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94143061
135EED_16625203_ChIP-ChIP_MESCs_Mouse0.94142024
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94123478
137KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94046792
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93453634
139SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93168884
140REST_21632747_ChIP-Seq_MESCs_Mouse0.92926078
141KDM2B_26808549_Chip-Seq_JURKAT_Human0.92579409
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.92314205
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92230998
144MAF_26560356_Chip-Seq_TH2_Human0.91839155
145ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91596277
146TP53_22127205_ChIP-Seq_IMR90_Human0.91253482
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.90754572
148AR_19668381_ChIP-Seq_PC3_Human0.90677837
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.90578686
150TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90508286
151CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90492727
152ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90471072
153UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89073145
154PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88560155
155SPI1_23547873_ChIP-Seq_NB4_Human0.88305420
156TFEB_21752829_ChIP-Seq_HELA_Human0.88293765
157CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87255641
158EGR1_19374776_ChIP-ChIP_THP-1_Human0.86967496
159CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86459504
160CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86223568
161SALL1_21062744_ChIP-ChIP_HESCs_Human0.85854741
162KLF4_19829295_ChIP-Seq_ESCs_Human0.85463711
163KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85419954
164MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85100538
165TCF4_18268006_ChIP-ChIP_LS174T_Human0.84581651
166PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84566954
167CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84335708
168* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83408339
169BCAT_22108803_ChIP-Seq_LS180_Human0.82847136
170LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82351603
171SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82154420
172ARNT_22903824_ChIP-Seq_MCF-7_Human0.82022382
173TCF4_23295773_ChIP-Seq_U87_Human0.81903136
174RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81653491
175P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80744778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence7.45202895
2MP0008877_abnormal_DNA_methylation7.34914021
3MP0005257_abnormal_intraocular_pressure5.69729301
4MP0003878_abnormal_ear_physiology5.38815004
5MP0005377_hearing/vestibular/ear_phenot5.38815004
6MP0003195_calcinosis3.07240817
7MP0003879_abnormal_hair_cell2.97656239
8MP0003123_paternal_imprinting2.87970143
9MP0003786_premature_aging2.84368003
10MP0010030_abnormal_orbit_morphology2.84007127
11MP0005410_abnormal_fertilization2.80824514
12MP0005058_abnormal_lysosome_morphology2.63872207
13MP0002210_abnormal_sex_determination2.51008984
14MP0000569_abnormal_digit_pigmentation2.49051779
15MP0002277_abnormal_respiratory_mucosa2.48167836
16MP0003787_abnormal_imprinting2.47898963
17MP0001929_abnormal_gametogenesis2.33892130
18MP0009840_abnormal_foam_cell2.33606554
19MP0001661_extended_life_span2.27511025
20MP0005647_abnormal_sex_gland2.25089531
21MP0003122_maternal_imprinting2.23147154
22MP0002132_abnormal_respiratory_system2.18840337
23MP0003045_fibrosis2.17708711
24MP0001145_abnormal_male_reproductive2.16630448
25MP0001727_abnormal_embryo_implantation2.08874095
26MP0002102_abnormal_ear_morphology2.07248147
27MP0003698_abnormal_male_reproductive2.04246034
28MP0002148_abnormal_hypersensitivity_rea2.02336418
29MP0006082_CNS_inflammation2.00883691
30MP0003172_abnormal_lysosome_physiology1.99279906
31MP0003315_abnormal_perineum_morphology1.91078960
32MP0000653_abnormal_sex_gland1.87573935
33MP0004859_abnormal_synaptic_plasticity1.86710500
34MP0003303_peritoneal_inflammation1.77192045
35MP0003121_genomic_imprinting1.75432708
36MP0001440_abnormal_grooming_behavior1.73991008
37MP0003436_decreased_susceptibility_to1.73730014
38MP0000751_myopathy1.69836172
39MP0009384_cardiac_valve_regurgitation1.67594361
40MP0005193_abnormal_anterior_eye1.62236370
41MP0008438_abnormal_cutaneous_collagen1.52932148
42MP0004147_increased_porphyrin_level1.52204253
43MP0005171_absent_coat_pigmentation1.50734984
44MP0005197_abnormal_uvea_morphology1.45045512
45MP0009785_altered_susceptibility_to1.41261837
46MP0004742_abnormal_vestibular_system1.39138576
47MP0003724_increased_susceptibility_to1.38630374
48MP0003936_abnormal_reproductive_system1.34963337
49MP0002998_abnormal_bone_remodeling1.32936374
50MP0002909_abnormal_adrenal_gland1.32536595
51MP0003075_altered_response_to1.31504419
52MP0002160_abnormal_reproductive_system1.31208110
53MP0002168_other_aberrant_phenotype1.30931000
54MP0006276_abnormal_autonomic_nervous1.30847742
55MP0004084_abnormal_cardiac_muscle1.28065671
56MP0005623_abnormal_meninges_morphology1.28050215
57MP0002837_dystrophic_cardiac_calcinosis1.27873260
58MP0000343_altered_response_to1.27507358
59MP0002139_abnormal_hepatobiliary_system1.26936996
60MP0001533_abnormal_skeleton_physiology1.25932187
61MP0004272_abnormal_basement_membrane1.22178550
62MP0003191_abnormal_cellular_cholesterol1.22115253
63MP0001853_heart_inflammation1.21861435
64MP0002419_abnormal_innate_immunity1.20674884
65MP0002332_abnormal_exercise_endurance1.20646490
66MP0005671_abnormal_response_to1.20227146
67MP0002933_joint_inflammation1.19388221
68MP0006138_congestive_heart_failure1.19207102
69MP0009278_abnormal_bone_marrow1.18621910
70MP0000639_abnormal_adrenal_gland1.17754619
71MP0002161_abnormal_fertility/fecundity1.15444191
72MP0005379_endocrine/exocrine_gland_phen1.14795485
73MP0003279_aneurysm1.11503002
74MP0005167_abnormal_blood-brain_barrier1.11413049
75MP0005000_abnormal_immune_tolerance1.11087397
76MP0005387_immune_system_phenotype1.09597683
77MP0001790_abnormal_immune_system1.09597683
78MP0003115_abnormal_respiratory_system1.08545512
79MP0009764_decreased_sensitivity_to1.07940445
80MP0002572_abnormal_emotion/affect_behav1.05433599
81MP0004036_abnormal_muscle_relaxation1.04788018
82MP0001958_emphysema1.03432281
83MP0005390_skeleton_phenotype1.02973206
84MP0003283_abnormal_digestive_organ1.02212338
85MP0001756_abnormal_urination1.00742792
86MP0005508_abnormal_skeleton_morphology1.00179978
87MP0003329_amyloid_beta_deposits0.98171190
88MP0009250_abnormal_appendicular_skeleto0.98106148
89MP0009780_abnormal_chondrocyte_physiolo0.97950530
90MP0004885_abnormal_endolymph0.97144815
91MP0005025_abnormal_response_to0.95903039
92MP0005076_abnormal_cell_differentiation0.94230766
93MP0001545_abnormal_hematopoietic_system0.93319476
94MP0005397_hematopoietic_system_phenotyp0.93319476
95MP0005451_abnormal_body_composition0.93264371
96MP0003635_abnormal_synaptic_transmissio0.92497807
97MP0005389_reproductive_system_phenotype0.90331412
98MP0004145_abnormal_muscle_electrophysio0.88694948
99MP0003942_abnormal_urinary_system0.88221993
100MP0002272_abnormal_nervous_system0.87737301
101MP0005365_abnormal_bile_salt0.86771016
102MP0009046_muscle_twitch0.85582313
103MP0003453_abnormal_keratinocyte_physiol0.85366637
104MP0001119_abnormal_female_reproductive0.83347165
105MP0002452_abnormal_antigen_presenting0.81851790
106MP0000026_abnormal_inner_ear0.80407306
107MP0003866_abnormal_defecation0.79181834
108MP0001963_abnormal_hearing_physiology0.78255056
109MP0000579_abnormal_nail_morphology0.78169614
110MP0002295_abnormal_pulmonary_circulatio0.77991560
111MP0005395_other_phenotype0.76651513
112MP0001845_abnormal_inflammatory_respons0.76481606
113MP0005645_abnormal_hypothalamus_physiol0.76341167
114MP0000631_abnormal_neuroendocrine_gland0.75973631
115MP0001501_abnormal_sleep_pattern0.75926732
116MP0000537_abnormal_urethra_morphology0.74563044
117MP0005275_abnormal_skin_tensile0.74542561
118MP0004510_myositis0.72294398
119MP0003699_abnormal_female_reproductive0.71903866
120MP0003656_abnormal_erythrocyte_physiolo0.71563600
121MP0003795_abnormal_bone_structure0.71140145
122MP0008469_abnormal_protein_level0.70222465
123MP0004947_skin_inflammation0.70183684
124MP0002723_abnormal_immune_serum0.69439086
125MP0003632_abnormal_nervous_system0.68770481
126MP0005166_decreased_susceptibility_to0.68654515
127MP0002653_abnormal_ependyma_morphology0.67972501
128MP0002063_abnormal_learning/memory/cond0.66933362
129MP0003119_abnormal_digestive_system0.66626788
130MP0000566_synostosis0.66349745
131MP0005248_abnormal_Harderian_gland0.66026461
132MP0009643_abnormal_urine_homeostasis0.65277311
133MP0002557_abnormal_social/conspecific_i0.64977874
134MP0003448_altered_tumor_morphology0.64773107
135MP0002163_abnormal_gland_morphology0.64736802
136MP0002092_abnormal_eye_morphology0.64515392
137MP0005408_hypopigmentation0.63535372
138MP0001919_abnormal_reproductive_system0.63080157
139MP0000490_abnormal_crypts_of0.61491151
140MP0004270_analgesia0.60259378
141MP0001835_abnormal_antigen_presentation0.59988181
142MP0002090_abnormal_vision0.59799757
143MP0004808_abnormal_hematopoietic_stem0.59744508
144MP0002136_abnormal_kidney_physiology0.59592515
145MP0002405_respiratory_system_inflammati0.58683275
146MP0009333_abnormal_splenocyte_physiolog0.58521057
147MP0000613_abnormal_salivary_gland0.57775345
148MP0004233_abnormal_muscle_weight0.57748649
149MP0000427_abnormal_hair_cycle0.57502096
150MP0003634_abnormal_glial_cell0.55928868
151MP0005332_abnormal_amino_acid0.55432486
152MP0002932_abnormal_joint_morphology0.55401861
153MP0003690_abnormal_glial_cell0.54936486
154MP0002896_abnormal_bone_mineralization0.54485723
155MP0004043_abnormal_pH_regulation0.54252961
156MP0003806_abnormal_nucleotide_metabolis0.53875531
157MP0002254_reproductive_system_inflammat0.53841277
158MP0001188_hyperpigmentation0.53260447
159MP0002420_abnormal_adaptive_immunity0.52815751
160MP0001819_abnormal_immune_cell0.52581268
161MP0002733_abnormal_thermal_nociception0.50752374
162MP0001851_eye_inflammation0.49830395
163MP0005310_abnormal_salivary_gland0.48853327
164MP0002064_seizures0.47584012
165MP0003646_muscle_fatigue0.47333405
166MP0005503_abnormal_tendon_morphology0.47203570
167MP0003091_abnormal_cell_migration0.45497948
168MP0004197_abnormal_fetal_growth/weight/0.43982575
169MP0009379_abnormal_foot_pigmentation0.43747070
170MP0005646_abnormal_pituitary_gland0.42493276
171MP0009745_abnormal_behavioral_response0.41174731
172MP0001485_abnormal_pinna_reflex0.40896812
173MP0006072_abnormal_retinal_apoptosis0.39125854
174MP0000604_amyloidosis0.38792197
175MP0003953_abnormal_hormone_level0.38414808
176MP0003300_gastrointestinal_ulcer0.37932747
177MP0002882_abnormal_neuron_morphology0.36554337
178MP0004811_abnormal_neuron_physiology0.35572987
179MP0004858_abnormal_nervous_system0.35373473

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)9.75690150
2Glomerulonephritis (HP:0000099)8.44595120
3Gonadotropin excess (HP:0000837)7.28651768
4Abnormality of liposaccharide metabolism (HP:0010968)6.68593451
5Abnormality of glycosphingolipid metabolism (HP:0004343)6.68593451
6Abnormality of glycolipid metabolism (HP:0010969)6.68593451
7Male pseudohermaphroditism (HP:0000037)6.65081599
8Sex reversal (HP:0012245)6.15961165
9Abnormal sex determination (HP:0012244)6.15961165
10Partial duplication of the phalanx of hand (HP:0009999)6.11779064
11Testicular neoplasm (HP:0010788)6.08109695
12Nephritis (HP:0000123)5.78907288
13Partial duplication of thumb phalanx (HP:0009944)5.54754912
14Azoospermia (HP:0000027)5.24884521
15Abnormality of male internal genitalia (HP:0000022)5.22573280
16Aplasia involving bones of the upper limbs (HP:0009823)5.03918728
17Aplasia of the phalanges of the hand (HP:0009802)5.03918728
18Aplasia involving bones of the extremities (HP:0009825)5.03918728
19Hand muscle atrophy (HP:0009130)4.92494900
20Ankle clonus (HP:0011448)4.89539139
21Recurrent corneal erosions (HP:0000495)4.58680722
22Corneal erosion (HP:0200020)4.57219342
23Infertility (HP:0000789)4.32623272
24Abnormal spermatogenesis (HP:0008669)4.14645470
25Facial diplegia (HP:0001349)4.12354439
2611 pairs of ribs (HP:0000878)3.99328480
27Corneal dystrophy (HP:0001131)3.96240624
28Tongue fasciculations (HP:0001308)3.92588905
29Upper limb amyotrophy (HP:0009129)3.89320171
30Distal upper limb amyotrophy (HP:0007149)3.89320171
31Mesangial abnormality (HP:0001966)3.85874741
32Hypoplasia of the uterus (HP:0000013)3.83919546
33Vacuolated lymphocytes (HP:0001922)3.83811015
34Increased cerebral lipofuscin (HP:0011813)3.78650558
35Germ cell neoplasia (HP:0100728)3.76465078
36Alacrima (HP:0000522)3.71267668
37Diaphragmatic weakness (HP:0009113)3.68462516
38Conical tooth (HP:0000698)3.63470994
39Muscle fibrillation (HP:0010546)3.62195892
40Mixed hearing impairment (HP:0000410)3.60877514
41Abnormality of the lower motor neuron (HP:0002366)3.56175555
42Stridor (HP:0010307)3.56106781
43Abnormality of incisor morphology (HP:0011063)3.51966287
44Neurofibrillary tangles (HP:0002185)3.49144620
45Metaphyseal cupping (HP:0003021)3.48596213
46Disinhibition (HP:0000734)3.38809390
47Nuclear cataract (HP:0100018)3.28425845
48Dysostosis multiplex (HP:0000943)3.22366231
49Hypoventilation (HP:0002791)3.22233258
50Systemic lupus erythematosus (HP:0002725)3.21447074
51Abnormality of macrophages (HP:0004311)3.20103308
52Nasolacrimal duct obstruction (HP:0000579)3.15104548
53Eczematoid dermatitis (HP:0000976)3.15049236
54Secondary amenorrhea (HP:0000869)3.11539409
55Occipital encephalocele (HP:0002085)3.03993218
56Increased neuronal autofluorescent lipopigment (HP:0002074)3.00316468
57Hypoplastic left heart (HP:0004383)3.00270415
58Decreased lacrimation (HP:0000633)2.91224441
59Loss of speech (HP:0002371)2.89566449
60Abnormality of the vocal cords (HP:0008777)2.89401952
61Xerostomia (HP:0000217)2.84906230
62Myopathic facies (HP:0002058)2.83364455
63Clumsiness (HP:0002312)2.82563907
64Mutism (HP:0002300)2.80871497
65Nonprogressive disorder (HP:0003680)2.80009848
66Clonus (HP:0002169)2.79576944
67Autoimmune thrombocytopenia (HP:0001973)2.79374618
68Broad hallux (HP:0010055)2.73673622
69Abnormality of the nasolacrimal system (HP:0000614)2.71619213
70Bladder diverticulum (HP:0000015)2.70018125
71Primary amenorrhea (HP:0000786)2.68076541
72Polycystic ovaries (HP:0000147)2.68022822
73Hematuria (HP:0000790)2.66810331
74Axonal loss (HP:0003447)2.66807772
75Turricephaly (HP:0000262)2.63203912
76Aplasia of the musculature (HP:0100854)2.57660484
77Myocardial infarction (HP:0001658)2.56858593
78Congenital glaucoma (HP:0001087)2.53485236
79Abnormality of the lacrimal duct (HP:0011481)2.51666874
80Abnormality of polysaccharide metabolism (HP:0011012)2.51006875
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51006875
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51006875
83Abnormality of the musculature of the hand (HP:0001421)2.50509986
84Aplasia/hypoplasia of the uterus (HP:0008684)2.48920319
85Rectal prolapse (HP:0002035)2.47858266
86Renovascular hypertension (HP:0100817)2.47746796
87Upper motor neuron abnormality (HP:0002127)2.47020718
88Urinary glycosaminoglycan excretion (HP:0003541)2.46533014
89Mucopolysacchariduria (HP:0008155)2.46533014
90Basal ganglia calcification (HP:0002135)2.45224990
91Ankle contracture (HP:0006466)2.43604478
92Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.42096831
93Missing ribs (HP:0000921)2.40244493
94Hypophosphatemia (HP:0002148)2.37368999
95Stage 5 chronic kidney disease (HP:0003774)2.37024896
96Pulmonary fibrosis (HP:0002206)2.36298035
97Generalized tonic-clonic seizures (HP:0002069)2.36133515
98Hyperacusis (HP:0010780)2.35740545
99Premature rupture of membranes (HP:0001788)2.34271072
100Absent phalangeal crease (HP:0006109)2.33318747
101Metaphyseal irregularity (HP:0003025)2.31282145
102Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.27971799
103Concave nail (HP:0001598)2.27331998
104Abnormality of the salivary glands (HP:0010286)2.25506638
105Duplication of thumb phalanx (HP:0009942)2.24881696
106Cerebral inclusion bodies (HP:0100314)2.24436506
107Broad toe (HP:0001837)2.23217665
108Polar cataract (HP:0010696)2.22840844
109Transposition of the great arteries (HP:0001669)2.21120702
110Abnormal connection of the cardiac segments (HP:0011545)2.21120702
111Abnormal ventriculo-arterial connection (HP:0011563)2.21120702
112Hypoplastic heart (HP:0001961)2.20298541
113Insomnia (HP:0100785)2.17499617
114Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.16928795
115Anomalous pulmonary venous return (HP:0010772)2.14827078
116Anterior segment dysgenesis (HP:0007700)2.10836894
117Hyponatremia (HP:0002902)2.10074833
118Premature ovarian failure (HP:0008209)2.08909110
119Protuberant abdomen (HP:0001538)2.07995865
120Ridged nail (HP:0001807)2.07503963
121Abnormality of the radial head (HP:0003995)2.06608303
122Paralysis (HP:0003470)2.06560659
123Hyperpituitarism (HP:0010514)2.04984928
124Diminished motivation (HP:0000745)2.04049578
125Myokymia (HP:0002411)2.03662392
126Apathy (HP:0000741)2.02356223
127Abnormality of the parietal bone (HP:0002696)2.01222729
128Male infertility (HP:0003251)10.0642007
129Retinal atrophy (HP:0001105)1.95848844
130Elfin facies (HP:0004428)1.94122209
131Abnormality of the pulmonary veins (HP:0011718)1.93869133
132Agnosia (HP:0010524)1.93783726
133Exostoses (HP:0100777)1.91068771
134Pointed chin (HP:0000307)1.89988064
135Fasciculations (HP:0002380)1.89171630
136Overriding aorta (HP:0002623)1.88703917
137Recurrent bacterial skin infections (HP:0005406)1.88371752
138Preaxial foot polydactyly (HP:0001841)1.87676980
139Nausea (HP:0002018)1.85923878
140Oligodactyly (HP:0012165)1.84842180
141Abnormality of permanent molar morphology (HP:0011071)1.84446988
142Abnormality of the dental root (HP:0006486)1.84446988
143Taurodontia (HP:0000679)1.84446988
144Neuronal loss in central nervous system (HP:0002529)1.84008097
145Recurrent gram-negative bacterial infections (HP:0005420)1.83630077
146Joint swelling (HP:0001386)1.83497807
147Abnormal finger flexion creases (HP:0006143)1.83317562
148Thoracic kyphosis (HP:0002942)1.83163072
149Abnormality of sodium homeostasis (HP:0010931)1.80591424
150Midline defect of the nose (HP:0004122)1.79397966
151Abnormality of the aortic arch (HP:0012303)1.79026968
152Recurrent abscess formation (HP:0002722)1.78435299
153Abnormality of molar morphology (HP:0011070)1.78146632
154Abnormality of molar (HP:0011077)1.78146632
155Hepatosplenomegaly (HP:0001433)1.78121418
156Exercise-induced myalgia (HP:0003738)1.77981311
157Increased variability in muscle fiber diameter (HP:0003557)1.77063287
158Flat cornea (HP:0007720)1.76343918
159Renal duplication (HP:0000075)1.74891426
160Dementia (HP:0000726)1.74847580
161Inappropriate behavior (HP:0000719)1.74326787
162Abnormality of the calcaneus (HP:0008364)1.72987330
163Poor head control (HP:0002421)1.72950997
164Abnormal pupillary function (HP:0007686)1.72162199
165Abnormality of the dental pulp (HP:0006479)1.71644285
166Spontaneous abortion (HP:0005268)1.63382530
167Childhood onset (HP:0011463)1.62072789
168Difficulty climbing stairs (HP:0003551)1.61794872
169True hermaphroditism (HP:0010459)1.61585522
170Arachnodactyly (HP:0001166)1.61104295
171Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.60739707
172Hypoplastic iliac wings (HP:0002866)1.60135222
173Cerebral aneurysm (HP:0004944)1.59895272
174Hyperkalemia (HP:0002153)1.58846863
175Lymphangioma (HP:0100764)1.57463110
176Focal seizures (HP:0007359)1.55905806
177Abnormality of dentin (HP:0010299)1.55315925
178Limb-girdle muscle weakness (HP:0003325)1.55225169
179Pulmonary artery stenosis (HP:0004415)1.55156256
180Hypoplasia of the iris (HP:0007676)1.51829224
181Inguinal hernia (HP:0000023)1.50516186
182Thin ribs (HP:0000883)1.50370002
183Postural tremor (HP:0002174)1.50110461
184Spinal muscular atrophy (HP:0007269)1.49996098
185Follicular hyperkeratosis (HP:0007502)1.46179210
186Bulbar palsy (HP:0001283)1.43125370
187Female pseudohermaphroditism (HP:0010458)1.42341190
188Nephronophthisis (HP:0000090)1.42091022
189Neoplasm of the heart (HP:0100544)1.41945160
190Hyporeflexia of lower limbs (HP:0002600)1.39712137
191Abnormality of skeletal muscle fiber size (HP:0012084)1.39706862
192Torticollis (HP:0000473)1.38159924
193Spastic gait (HP:0002064)1.35585676
194Shoulder girdle muscle weakness (HP:0003547)1.34861427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.42767522
2TYRO35.06122684
3PRKD34.17313693
4CDK124.07717691
5MOS3.90156587
6GRK73.83788784
7NTRK33.78979829
8WNK33.76788500
9RIPK43.08582803
10TGFBR23.01714728
11MAP3K42.89811688
12ICK2.68820529
13DDR22.52841981
14PIM22.33753678
15PDK22.28338641
16TAOK22.26335786
17CASK2.24298958
18ARAF2.17205772
19BRD42.17099673
20PTK2B2.15982498
21IRAK32.14899106
22BLK2.04481997
23MAP3K141.94334378
24TRIB31.86089925
25STK38L1.85246551
26CDK91.81594813
27DAPK21.80904473
28TBK11.66042668
29RIPK11.62827148
30KSR21.53966424
31GRK51.52492543
32LATS11.52131098
33MAP3K31.50477988
34WNK11.49752891
35WNK41.47764928
36PAK61.45612282
37MAP3K111.45553444
38PTK61.45339655
39TNK21.38998521
40MAP2K71.35614811
41LATS21.35013460
42CDK71.33363775
43CSNK1A1L1.33060344
44TTN1.31956106
45MINK11.31248294
46PRKD21.29794017
47MAP3K91.29682084
48CSK1.29592598
49STK101.28779334
50TESK21.28579974
51ABL21.24429569
52FGR1.19728708
53CAMK2B1.19399941
54KDR1.18317406
55ADRBK21.17609910
56IRAK41.17567233
57CSNK1G21.16775857
58FER1.15684359
59CSNK1G31.15233146
60STK241.13164906
61LMTK21.13099800
62CDK41.08792925
63RPS6KL11.08674436
64RPS6KC11.08674436
65CAMK1G1.04316349
66IKBKE1.04007488
67ZAP701.03704566
68CDC71.03035386
69EPHB11.02133972
70NEK11.01822993
71NTRK21.00544636
72MAPK70.99803595
73NTRK10.98966222
74TESK10.98647866
75MATK0.98415325
76MYLK0.97951384
77IKBKB0.95533386
78MAP2K40.93595004
79SYK0.92859717
80EEF2K0.92497769
81MAP2K20.92231611
82CAMK1D0.91834669
83RPS6KA60.89479517
84MAPK130.88428856
85CSNK1G10.87638478
86LIMK10.86214699
87PAK30.85975738
88PDK30.85251102
89PDK40.85251102
90MAP3K100.85213116
91RET0.85164088
92STK30.84831682
93TAOK10.83821827
94MTOR0.82140416
95NEK20.81956076
96TYK20.81802316
97SIK10.79829718
98JAK30.78549820
99PAK20.77603975
100MKNK10.75729544
101PLK20.75629836
102MAP3K130.75624446
103CDC42BPA0.75604743
104EIF2AK20.73165197
105PKN20.73122678
106IRAK20.73109232
107MAP3K20.72034199
108PRKCH0.67498595
109CHUK0.66701231
110PDGFRA0.65748771
111DAPK30.65369422
112MAP3K50.64754347
113PNCK0.63184091
114MAPKAPK50.62768776
115LRRK20.61125121
116STK380.60731078
117INSR0.60662346
118DAPK10.59869660
119FES0.59783346
120LYN0.59776872
121MAPK40.58632645
122KSR10.58038150
123PTK20.56927772
124DMPK0.56595828
125TRPM70.56518585
126CAMKK20.52616533
127JAK20.51575683
128IRAK10.51314445
129OBSCN0.50927378
130PRKACB0.49613458
131PAK40.49159354
132CDK50.48417323
133TNIK0.47774380
134MAP2K30.46757684
135MAPK150.46674936
136PDK10.45616740
137PRPF4B0.45225214
138PRKCQ0.45093318
139MAP3K10.43175403
140SCYL20.42892450
141RPS6KA20.42664960
142TXK0.42491208
143NEK90.42304864
144ITK0.42052393
145BMX0.41730802
146BMPR20.40721907
147SGK2230.40609283
148SGK4940.40609283
149CHEK10.40190287
150CAMK10.39292342
151MARK30.38771366
152GSK3B0.38752730
153AKT20.38714855
154MAPK10.38115031
155MAP2K60.37925630
156ABL10.37824060
157STK390.37727559
158ATR0.37319989
159CAMK2A0.37109711
160BCKDK0.37054472
161ATM0.36971429
162MAPK30.36242457
163CLK10.35788330
164LCK0.35602474
165PDPK10.34201491
166PRKCD0.32235036
167PRKDC0.32189730
168RPS6KA30.31917398
169MAP3K80.31366035
170MAPK80.30640144
171SGK30.29605421
172STK110.29535931
173MAPK140.28082559
174PIM10.27767458
175MAPK120.27018739
176CSNK1E0.26702480
177CDK10.26541730
178PLK10.25486405
179ROCK10.24453140

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.18250023
2Lysosome_Homo sapiens_hsa041423.86954593
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.17632218
4Rheumatoid arthritis_Homo sapiens_hsa053233.12683058
5Dorso-ventral axis formation_Homo sapiens_hsa043203.07466206
6Nitrogen metabolism_Homo sapiens_hsa009102.54892463
7Fatty acid biosynthesis_Homo sapiens_hsa000612.52741744
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.42451505
9Collecting duct acid secretion_Homo sapiens_hsa049662.37609644
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.37063387
11Ovarian steroidogenesis_Homo sapiens_hsa049132.25237926
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.06694777
13Renin secretion_Homo sapiens_hsa049242.03971566
14Hedgehog signaling pathway_Homo sapiens_hsa043402.02295703
15Osteoclast differentiation_Homo sapiens_hsa043802.01871223
16Sulfur metabolism_Homo sapiens_hsa009201.97520515
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90831109
18Staphylococcus aureus infection_Homo sapiens_hsa051501.89699910
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.88197342
20Leishmaniasis_Homo sapiens_hsa051401.85979940
21Cocaine addiction_Homo sapiens_hsa050301.85401714
22Axon guidance_Homo sapiens_hsa043601.84478953
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84382201
24Vitamin digestion and absorption_Homo sapiens_hsa049771.84380978
25Allograft rejection_Homo sapiens_hsa053301.79450552
26Amphetamine addiction_Homo sapiens_hsa050311.79279784
27Malaria_Homo sapiens_hsa051441.79271136
28Phagosome_Homo sapiens_hsa041451.72937908
29Tuberculosis_Homo sapiens_hsa051521.70159925
30ECM-receptor interaction_Homo sapiens_hsa045121.68595312
31Synaptic vesicle cycle_Homo sapiens_hsa047211.65195891
32Amoebiasis_Homo sapiens_hsa051461.64880189
33TGF-beta signaling pathway_Homo sapiens_hsa043501.64583238
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.60656246
35cAMP signaling pathway_Homo sapiens_hsa040241.60200533
36Oocyte meiosis_Homo sapiens_hsa041141.50949953
37Fatty acid metabolism_Homo sapiens_hsa012121.50538974
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47961011
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47873456
40Dopaminergic synapse_Homo sapiens_hsa047281.47146426
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.46358058
42Lysine degradation_Homo sapiens_hsa003101.44447070
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.44136648
44Legionellosis_Homo sapiens_hsa051341.43011811
45mRNA surveillance pathway_Homo sapiens_hsa030151.42492788
46Vibrio cholerae infection_Homo sapiens_hsa051101.42370256
47Asthma_Homo sapiens_hsa053101.38323330
48Oxytocin signaling pathway_Homo sapiens_hsa049211.37526177
49TNF signaling pathway_Homo sapiens_hsa046681.36233395
50Pertussis_Homo sapiens_hsa051331.33565422
51Long-term potentiation_Homo sapiens_hsa047201.33436066
52Galactose metabolism_Homo sapiens_hsa000521.32413160
53Pentose phosphate pathway_Homo sapiens_hsa000301.32004876
54Estrogen signaling pathway_Homo sapiens_hsa049151.31587911
55Circadian entrainment_Homo sapiens_hsa047131.30838242
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30704832
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.29182949
58Small cell lung cancer_Homo sapiens_hsa052221.28202221
59Fructose and mannose metabolism_Homo sapiens_hsa000511.27974335
60Graft-versus-host disease_Homo sapiens_hsa053321.27602492
61Vascular smooth muscle contraction_Homo sapiens_hsa042701.26811429
62Gastric acid secretion_Homo sapiens_hsa049711.26464518
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25227330
64Phospholipase D signaling pathway_Homo sapiens_hsa040721.23375759
65Serotonergic synapse_Homo sapiens_hsa047261.22977944
66Mineral absorption_Homo sapiens_hsa049781.22645542
67Notch signaling pathway_Homo sapiens_hsa043301.16673820
68Autoimmune thyroid disease_Homo sapiens_hsa053201.15673166
69Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14579997
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13041362
71Fatty acid elongation_Homo sapiens_hsa000621.12341930
72Salivary secretion_Homo sapiens_hsa049701.10831628
73Sphingolipid metabolism_Homo sapiens_hsa006001.10242116
74Protein digestion and absorption_Homo sapiens_hsa049741.08516018
75Focal adhesion_Homo sapiens_hsa045101.07407875
76GnRH signaling pathway_Homo sapiens_hsa049121.07152037
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06730772
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04426632
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02972713
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01657038
81Antigen processing and presentation_Homo sapiens_hsa046121.01042120
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00552171
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99970093
84Insulin secretion_Homo sapiens_hsa049110.99490692
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97739299
86Viral myocarditis_Homo sapiens_hsa054160.96411818
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95040652
88Glutamatergic synapse_Homo sapiens_hsa047240.94443434
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.94363850
90Glioma_Homo sapiens_hsa052140.93689176
91Oxidative phosphorylation_Homo sapiens_hsa001900.92709366
92Nicotine addiction_Homo sapiens_hsa050330.92061318
93Type I diabetes mellitus_Homo sapiens_hsa049400.91210481
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90733553
95Pyruvate metabolism_Homo sapiens_hsa006200.89465574
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89340877
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88798384
98Basal transcription factors_Homo sapiens_hsa030220.88430742
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88415279
100Tight junction_Homo sapiens_hsa045300.88381135
101Tryptophan metabolism_Homo sapiens_hsa003800.88377633
102GABAergic synapse_Homo sapiens_hsa047270.88282562
103Bladder cancer_Homo sapiens_hsa052190.87711858
104Morphine addiction_Homo sapiens_hsa050320.86725224
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85848792
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85343682
107Olfactory transduction_Homo sapiens_hsa047400.84446880
108Choline metabolism in cancer_Homo sapiens_hsa052310.84306780
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.83554128
110Hippo signaling pathway_Homo sapiens_hsa043900.79947352
111ErbB signaling pathway_Homo sapiens_hsa040120.79936234
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79583453
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79403980
114VEGF signaling pathway_Homo sapiens_hsa043700.78572520
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78182869
116Wnt signaling pathway_Homo sapiens_hsa043100.77161128
117Primary immunodeficiency_Homo sapiens_hsa053400.76707513
118Basal cell carcinoma_Homo sapiens_hsa052170.76308884
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75475900
120Long-term depression_Homo sapiens_hsa047300.75307224
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74914261
122Inositol phosphate metabolism_Homo sapiens_hsa005620.74843489
123Herpes simplex infection_Homo sapiens_hsa051680.72504329
124Endometrial cancer_Homo sapiens_hsa052130.71869643
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71312494
126Carbon metabolism_Homo sapiens_hsa012000.70864000
127Calcium signaling pathway_Homo sapiens_hsa040200.70155504
128Hematopoietic cell lineage_Homo sapiens_hsa046400.69424568
129Melanogenesis_Homo sapiens_hsa049160.69335718
130Cholinergic synapse_Homo sapiens_hsa047250.69331331
131Influenza A_Homo sapiens_hsa051640.68923612
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64439845
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.63937943
134Gap junction_Homo sapiens_hsa045400.63770511
135Vitamin B6 metabolism_Homo sapiens_hsa007500.62450666
136Glucagon signaling pathway_Homo sapiens_hsa049220.62048467
137Circadian rhythm_Homo sapiens_hsa047100.61669581
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61257805
139Apoptosis_Homo sapiens_hsa042100.60794856
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60130745
141Adherens junction_Homo sapiens_hsa045200.60092110
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.59296013
143Prolactin signaling pathway_Homo sapiens_hsa049170.57705107
144Melanoma_Homo sapiens_hsa052180.56735914
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55791336
146Toxoplasmosis_Homo sapiens_hsa051450.55278897
147Type II diabetes mellitus_Homo sapiens_hsa049300.55145829
148Chemokine signaling pathway_Homo sapiens_hsa040620.54894337
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54806063
150B cell receptor signaling pathway_Homo sapiens_hsa046620.53444038
151Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52611930
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51844823
153African trypanosomiasis_Homo sapiens_hsa051430.51118807
154SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50950797
155Colorectal cancer_Homo sapiens_hsa052100.50269914
156Thyroid hormone synthesis_Homo sapiens_hsa049180.48694658
157Prion diseases_Homo sapiens_hsa050200.47896933
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47838448
159Pathways in cancer_Homo sapiens_hsa052000.47666638
160Complement and coagulation cascades_Homo sapiens_hsa046100.47133908
161PPAR signaling pathway_Homo sapiens_hsa033200.46997611
162mTOR signaling pathway_Homo sapiens_hsa041500.46819321
163Salmonella infection_Homo sapiens_hsa051320.46613743
164Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46378066
165Alcoholism_Homo sapiens_hsa050340.45642176
166Steroid hormone biosynthesis_Homo sapiens_hsa001400.45609879
167HIF-1 signaling pathway_Homo sapiens_hsa040660.45501685
168Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44074082
169Parkinsons disease_Homo sapiens_hsa050120.39828527
170Glutathione metabolism_Homo sapiens_hsa004800.39487905
171Shigellosis_Homo sapiens_hsa051310.39223860
172Hepatitis C_Homo sapiens_hsa051600.37804095
173Endocytosis_Homo sapiens_hsa041440.36420737
174Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33868176
175Alzheimers disease_Homo sapiens_hsa050100.33578236
176Measles_Homo sapiens_hsa051620.33549830
177Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33318009
178Hepatitis B_Homo sapiens_hsa051610.32076125
179beta-Alanine metabolism_Homo sapiens_hsa004100.30293540
180Proteoglycans in cancer_Homo sapiens_hsa052050.28921925
181Rap1 signaling pathway_Homo sapiens_hsa040150.26851995

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