TMEM100

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1blood vessel maturation (GO:0001955)7.68341756
2surfactant homeostasis (GO:0043129)6.68771861
3endothelial tube morphogenesis (GO:0061154)5.36786793
4morphogenesis of an endothelium (GO:0003159)5.36786793
5lymphangiogenesis (GO:0001946)5.34562068
6chemical homeostasis within a tissue (GO:0048875)5.22654077
7* regulation of endothelial cell differentiation (GO:0045601)5.11845835
8* positive regulation of endothelial cell differentiation (GO:0045603)5.08353445
9artery development (GO:0060840)4.66171716
10lymph vessel development (GO:0001945)4.65765668
11negative regulation of platelet activation (GO:0010544)4.52947402
12cellular response to nitric oxide (GO:0071732)4.25585304
13* endothelial cell differentiation (GO:0045446)4.13448578
14vascular endothelial growth factor signaling pathway (GO:0038084)4.07925313
15locomotory exploration behavior (GO:0035641)4.07313046
16* regulation of vasculogenesis (GO:2001212)3.93702310
17endothelium development (GO:0003158)3.89812335
18cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.78506933
19postsynaptic membrane organization (GO:0001941)3.74575489
20regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.62421134
21retina vasculature morphogenesis in camera-type eye (GO:0061299)3.56766612
22cGMP-mediated signaling (GO:0019934)3.56605179
23glomerular basement membrane development (GO:0032836)3.50626360
24positive regulation of osteoblast proliferation (GO:0033690)3.45346868
25endothelial cell proliferation (GO:0001935)3.41761035
26renal filtration (GO:0097205)3.40774895
27cellular response to reactive nitrogen species (GO:1902170)3.40706188
28glomerular filtration (GO:0003094)3.39312497
29photoreceptor cell differentiation (GO:0046530)3.36287294
30eye photoreceptor cell differentiation (GO:0001754)3.36287294
31negative regulation of endothelial cell proliferation (GO:0001937)3.34544994
32regulation of glomerular filtration (GO:0003093)3.29607928
33one-carbon compound transport (GO:0019755)3.29119015
34peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.28822757
35toxin metabolic process (GO:0009404)3.25615582
36blood vessel remodeling (GO:0001974)3.21980960
37lung vasculature development (GO:0060426)3.19403660
38hyperosmotic salinity response (GO:0042538)3.19196414
39endocardial cushion morphogenesis (GO:0003203)3.17130095
40negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.12982242
41lung lobe morphogenesis (GO:0060463)3.11286768
42wound healing, spreading of epidermal cells (GO:0035313)3.10584407
43cAMP biosynthetic process (GO:0006171)3.07966474
44extracellular fibril organization (GO:0043206)3.04746291
45respiratory tube development (GO:0030323)3.02548754
46dermatan sulfate biosynthetic process (GO:0030208)3.02332441
47response to nitric oxide (GO:0071731)3.02076987
48endothelial cell morphogenesis (GO:0001886)3.00612842
49neuron cell-cell adhesion (GO:0007158)3.00594189
50enteric nervous system development (GO:0048484)2.99952725
51positive regulation of chondrocyte differentiation (GO:0032332)2.99654995
52dermatan sulfate metabolic process (GO:0030205)2.95859998
53positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.95118218
54positive regulation of macrophage cytokine production (GO:0060907)2.94544208
55response to xenobiotic stimulus (GO:0009410)2.94481031
56anatomical structure maturation (GO:0071695)2.94014891
57chondroitin sulfate catabolic process (GO:0030207)2.92795564
58negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.91009272
59vitamin A metabolic process (GO:0006776)2.90706400
60positive regulation of cellular amide metabolic process (GO:0034250)2.88484739
61presynaptic membrane assembly (GO:0097105)2.88268115
62sodium ion homeostasis (GO:0055078)2.87701213
63positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.87589723
64exploration behavior (GO:0035640)2.87307560
65vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.86141676
66respiratory gaseous exchange (GO:0007585)2.85685686
67induction of positive chemotaxis (GO:0050930)2.83189250
68venous blood vessel morphogenesis (GO:0048845)2.81271445
69Notch signaling involved in heart development (GO:0061314)2.80548745
70negative regulation of complement activation (GO:0045916)2.79998572
71cell migration involved in sprouting angiogenesis (GO:0002042)2.79050775
72vasculature development (GO:0001944)2.77459882
73heart trabecula morphogenesis (GO:0061384)2.76023385
74negative regulation of catenin import into nucleus (GO:0035414)2.74614370
75nephron tubule formation (GO:0072079)2.72442081
76endocrine hormone secretion (GO:0060986)2.71290279
77regulation of integrin-mediated signaling pathway (GO:2001044)2.69803217
78astrocyte differentiation (GO:0048708)2.69799454
79positive regulation of cartilage development (GO:0061036)2.67095190
80metanephric nephron tubule development (GO:0072234)2.66773264
81metanephric tubule development (GO:0072170)2.66773264
82regulation of axon guidance (GO:1902667)2.65480528
83negative regulation of Rho protein signal transduction (GO:0035024)2.65374194
84mesodermal cell differentiation (GO:0048333)2.64946947
85negative regulation of sodium ion transport (GO:0010766)2.64426987
86L-amino acid import (GO:0043092)2.63108477
87metanephric nephron epithelium development (GO:0072243)2.63019521
88heart valve formation (GO:0003188)2.62194701
89trabecula morphogenesis (GO:0061383)2.62038227
90midgut development (GO:0007494)2.61378497
91regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.61320693
92regulation of axon extension involved in axon guidance (GO:0048841)2.61283677
93metanephric epithelium development (GO:0072207)2.61211909
94basement membrane organization (GO:0071711)2.61160618
95renal system process involved in regulation of blood volume (GO:0001977)2.61040206
96renal absorption (GO:0070293)2.60114973
97virion attachment to host cell (GO:0019062)2.59855421
98adhesion of symbiont to host cell (GO:0044650)2.59855421
99* positive regulation of vasculogenesis (GO:2001214)2.59715265
100mesenchyme morphogenesis (GO:0072132)2.57343603
101positive regulation of p38MAPK cascade (GO:1900745)2.57141808
102negative regulation of adherens junction organization (GO:1903392)2.54540475
103negative regulation of focal adhesion assembly (GO:0051895)2.54540475
104negative regulation of cell junction assembly (GO:1901889)2.54540475
105regulation of p38MAPK cascade (GO:1900744)2.54250744
106import into cell (GO:0098657)2.53090978
107peptidyl-tyrosine autophosphorylation (GO:0038083)2.52644214
108negative regulation of blood vessel endothelial cell migration (GO:0043537)2.52609281
109axon extension involved in axon guidance (GO:0048846)2.52376746
110neuron projection extension involved in neuron projection guidance (GO:1902284)2.52376746
111cell migration involved in heart development (GO:0060973)2.51464227
112regulation of platelet activation (GO:0010543)2.50626336
113peptide catabolic process (GO:0043171)2.50515094
114negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.49681133
115* vasculogenesis (GO:0001570)2.49341399
116cell volume homeostasis (GO:0006884)2.48550678
117neurotransmitter uptake (GO:0001504)2.48512838
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.48277851
119keratan sulfate catabolic process (GO:0042340)2.47443993
120positive regulation of BMP signaling pathway (GO:0030513)2.46648218
121negative regulation of protein activation cascade (GO:2000258)2.46403825
122negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.45803826
123positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.45709635
124alanine transport (GO:0032328)2.45263827
125amino acid import (GO:0043090)2.44943705
126patterning of blood vessels (GO:0001569)2.44052373
127chondroitin sulfate biosynthetic process (GO:0030206)2.43969086
128fibril organization (GO:0097435)2.43658441
129L-serine transport (GO:0015825)2.42861579
130cellular sodium ion homeostasis (GO:0006883)2.42537190
131hormone catabolic process (GO:0042447)2.41978429
132regulation of neuron projection regeneration (GO:0070570)2.41428607
133regulation of axon regeneration (GO:0048679)2.41428607
134polarized epithelial cell differentiation (GO:0030859)2.40932466
135presynaptic membrane organization (GO:0097090)2.40919008
136camera-type eye morphogenesis (GO:0048593)2.40479216
137regulation of glucose import in response to insulin stimulus (GO:2001273)2.39412239
138cellular response to cadmium ion (GO:0071276)2.39013785
139vocalization behavior (GO:0071625)2.36531626
140positive regulation of astrocyte differentiation (GO:0048711)2.34741821
141appendage development (GO:0048736)2.33286855
142limb development (GO:0060173)2.33286855
143negative regulation of protein localization to cell surface (GO:2000009)2.33202426
144adhesion of symbiont to host (GO:0044406)2.32711239
145sprouting angiogenesis (GO:0002040)2.32381751
146positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.32050356
147membrane assembly (GO:0071709)2.32036493
148phagocytosis, recognition (GO:0006910)2.31673384
149establishment or maintenance of monopolar cell polarity (GO:0061339)2.30583562
150establishment of monopolar cell polarity (GO:0061162)2.30583562
151negative regulation of vascular permeability (GO:0043116)2.30196853
152embryonic foregut morphogenesis (GO:0048617)2.29813459
153positive regulation of focal adhesion assembly (GO:0051894)2.29572703
154positive regulation of cell junction assembly (GO:1901890)2.29572703
155positive regulation of neurological system process (GO:0031646)2.28175876
156cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.27942111
157oligodendrocyte differentiation (GO:0048709)2.27410267
158negative regulation of endothelial cell migration (GO:0010596)2.26571689
159cell proliferation involved in metanephros development (GO:0072203)2.25036232
160developmental induction (GO:0031128)2.25000068
161neurotransmitter-gated ion channel clustering (GO:0072578)2.24102805
162negative regulation of axon extension involved in axon guidance (GO:0048843)2.23893618
163negative regulation of homotypic cell-cell adhesion (GO:0034111)2.23629002
164negative regulation of cardiac muscle tissue growth (GO:0055022)2.23520091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.91108161
2GATA1_22025678_ChIP-Seq_K562_Human3.32355679
3SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.74055844
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65081885
5CLOCK_20551151_ChIP-Seq_293T_Human2.59507871
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.50479011
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46816814
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39909305
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.29792664
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27771373
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24072118
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.21397731
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18275944
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17119700
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17017799
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17017799
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.12636147
18AR_21572438_ChIP-Seq_LNCaP_Human2.08977931
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98124272
20GATA2_21666600_ChIP-Seq_HMVEC_Human1.93546173
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.92138404
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90130941
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88937448
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87716150
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.84494786
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80845233
27EZH2_22144423_ChIP-Seq_EOC_Human1.77137808
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74190829
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73627110
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72241969
31BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.69834458
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.68710184
33CJUN_26792858_Chip-Seq_BT549_Human1.66112902
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.65730409
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59299471
36GBX2_23144817_ChIP-Seq_PC3_Human1.59080039
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57693165
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55657891
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.52383036
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51963244
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.47892014
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.46361854
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41745310
44TP53_18474530_ChIP-ChIP_U2OS_Human1.40790047
45AHR_22903824_ChIP-Seq_MCF-7_Human1.40783837
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39397608
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.39246180
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39050375
49* BCAT_22108803_ChIP-Seq_LS180_Human1.34952918
50TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34921482
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34165551
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32096076
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.30366188
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29112971
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28000923
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27898779
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27898779
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27411118
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24295552
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24145040
61SOX2_20726797_ChIP-Seq_SW620_Human1.23422714
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.23170905
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.21403356
64ISL1_27105846_Chip-Seq_CPCs_Mouse1.20067127
65* PIAS1_25552417_ChIP-Seq_VCAP_Human1.17875864
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.17651052
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17087894
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17033899
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15084630
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.14813509
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14058620
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13569811
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.12940029
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12822123
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.12762909
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10447381
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10445957
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06514197
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.06288984
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05308609
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.04633986
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.04633986
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.04456485
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03087189
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01172825
86RXR_22108803_ChIP-Seq_LS180_Human1.00683188
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.00656581
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00498056
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99716280
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99681102
91* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99527585
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99476452
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99237980
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98583659
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97804947
96KDM2B_26808549_Chip-Seq_K562_Human0.96976225
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96747551
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96747551
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96747551
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95496628
101* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94753786
102ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94576451
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93371446
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93284787
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92729336
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91027902
107KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90481351
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.90403685
109AR_25329375_ChIP-Seq_VCAP_Human0.90033873
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89802774
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.88612987
112SMAD4_21799915_ChIP-Seq_A2780_Human0.88381837
113TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88268310
114TP53_16413492_ChIP-PET_HCT116_Human0.87332392
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87070341
116DROSHA_22980978_ChIP-Seq_HELA_Human0.85345949
117SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85327055
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84960911
119TP63_23658742_ChIP-Seq_EP156T_Human0.83114127
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82769974
121P300_19829295_ChIP-Seq_ESCs_Human0.81156554
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.79981608
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79021443
124SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78692690
125* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77852482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.28546800
2MP0001879_abnormal_lymphatic_vessel4.90543115
3MP0001958_emphysema4.85984170
4MP0005167_abnormal_blood-brain_barrier4.06534915
5MP0002138_abnormal_hepatobiliary_system4.03114511
6MP0004858_abnormal_nervous_system3.07091964
7MP0004782_abnormal_surfactant_physiolog2.98574745
8MP0004272_abnormal_basement_membrane2.96160016
9MP0003279_aneurysm2.91590070
10MP0003724_increased_susceptibility_to2.77597616
11MP0008438_abnormal_cutaneous_collagen2.73156543
12MP0005171_absent_coat_pigmentation2.67068576
13MP0000767_abnormal_smooth_muscle2.30591507
14MP0005595_abnormal_vascular_smooth2.28906649
15MP0000343_altered_response_to2.16237883
16MP0002295_abnormal_pulmonary_circulatio2.09791203
17MP0003136_yellow_coat_color2.08701881
18MP0005503_abnormal_tendon_morphology2.05795248
19MP0005275_abnormal_skin_tensile2.01923218
20MP0004883_abnormal_blood_vessel1.93418004
21MP0005164_abnormal_response_to1.91642921
22MP0003941_abnormal_skin_development1.84079597
23MP0003075_altered_response_to1.83771195
24MP0006138_congestive_heart_failure1.81654833
25MP0002133_abnormal_respiratory_system1.74222360
26MP0005388_respiratory_system_phenotype1.74222360
27MP0005165_increased_susceptibility_to1.71235229
28MP0009384_cardiac_valve_regurgitation1.71132924
29MP0006054_spinal_hemorrhage1.65621389
30MP0002132_abnormal_respiratory_system1.63913340
31MP0003690_abnormal_glial_cell1.62087045
32MP0000534_abnormal_ureter_morphology1.59702519
33MP0000249_abnormal_blood_vessel1.57460539
34MP0005670_abnormal_white_adipose1.55787415
35MP0003828_pulmonary_edema1.54998440
36MP0004130_abnormal_muscle_cell1.53039340
37MP0001502_abnormal_circadian_rhythm1.46988470
38MP0000465_gastrointestinal_hemorrhage1.45711742
39MP0001542_abnormal_bone_strength1.43636823
40MP0003566_abnormal_cell_adhesion1.35484894
41MP0003191_abnormal_cellular_cholesterol1.34377258
42MP0003091_abnormal_cell_migration1.31580938
43MP0005508_abnormal_skeleton_morphology1.27100274
44MP0003950_abnormal_plasma_membrane1.26110602
45MP0004085_abnormal_heartbeat1.20986187
46MP0002128_abnormal_blood_circulation1.20332842
47MP0004484_altered_response_of1.19707414
48MP0005385_cardiovascular_system_phenoty1.19449191
49MP0001544_abnormal_cardiovascular_syste1.19449191
50MP0002332_abnormal_exercise_endurance1.16360896
51MP0002127_abnormal_cardiovascular_syste1.13377401
52MP0001501_abnormal_sleep_pattern1.11468955
53MP0004885_abnormal_endolymph1.10600394
54MP0001440_abnormal_grooming_behavior1.09062549
55MP0001986_abnormal_taste_sensitivity1.08308297
56MP0002972_abnormal_cardiac_muscle1.06761657
57MP0001177_atelectasis1.06592397
58MP0001175_abnormal_lung_morphology1.05743896
59MP0000920_abnormal_myelination1.04962289
60MP0009250_abnormal_appendicular_skeleto1.03080492
61MP0009780_abnormal_chondrocyte_physiolo1.03065969
62MP0005166_decreased_susceptibility_to1.02668185
63MP0000733_abnormal_muscle_development1.00338387
64MP0004084_abnormal_cardiac_muscle0.98726177
65MP0008995_early_reproductive_senescence0.95923045
66MP0003705_abnormal_hypodermis_morpholog0.95417163
67MP0009764_decreased_sensitivity_to0.95082346
68MP0002282_abnormal_trachea_morphology0.94147243
69MP0000230_abnormal_systemic_arterial0.92834858
70MP0005666_abnormal_adipose_tissue0.92264270
71MP0001486_abnormal_startle_reflex0.91899507
72MP0002736_abnormal_nociception_after0.90346564
73MP0009053_abnormal_anal_canal0.89692966
74MP0000778_abnormal_nervous_system0.89546884
75MP0001968_abnormal_touch/_nociception0.88252964
76MP0003115_abnormal_respiratory_system0.88018219
77MP0005375_adipose_tissue_phenotype0.87556703
78MP0005423_abnormal_somatic_nervous0.87153933
79MP0002254_reproductive_system_inflammat0.86481870
80MP0001614_abnormal_blood_vessel0.86414601
81MP0008004_abnormal_stomach_pH0.86101284
82MP0004859_abnormal_synaptic_plasticity0.85391134
83MP0002925_abnormal_cardiovascular_devel0.84487862
84MP0010030_abnormal_orbit_morphology0.84193529
85MP0003385_abnormal_body_wall0.84011243
86MP0003283_abnormal_digestive_organ0.83825876
87MP0000751_myopathy0.83470589
88MP0001270_distended_abdomen0.79772583
89MP0005620_abnormal_muscle_contractility0.78711728
90MP0002909_abnormal_adrenal_gland0.78543371
91MP0000003_abnormal_adipose_tissue0.78476543
92MP0002735_abnormal_chemical_nociception0.76834553
93MP0005623_abnormal_meninges_morphology0.76753503
94MP0002653_abnormal_ependyma_morphology0.75375467
95MP0003119_abnormal_digestive_system0.74747841
96MP0004036_abnormal_muscle_relaxation0.74598999
97MP0003632_abnormal_nervous_system0.73855960
98MP0002971_abnormal_brown_adipose0.73652642
99MP0003329_amyloid_beta_deposits0.72416235
100MP0004215_abnormal_myocardial_fiber0.72300598
101MP0001970_abnormal_pain_threshold0.71615054
102MP0001299_abnormal_eye_distance/0.71592857
103MP0001756_abnormal_urination0.71010107
104MP0005058_abnormal_lysosome_morphology0.70993430
105MP0001661_extended_life_span0.70947780
106MP0003942_abnormal_urinary_system0.70831565
107MP0002896_abnormal_bone_mineralization0.70399486
108MP0001915_intracranial_hemorrhage0.70349456
109MP0000537_abnormal_urethra_morphology0.70309548
110MP0001943_abnormal_respiration0.69224636
111MP0002734_abnormal_mechanical_nocicepti0.68863701
112MP0005023_abnormal_wound_healing0.67872721
113MP0000750_abnormal_muscle_regeneration0.67444422
114MP0003635_abnormal_synaptic_transmissio0.67151293
115MP0000013_abnormal_adipose_tissue0.66436747
116MP0003633_abnormal_nervous_system0.66296609
117MP0000462_abnormal_digestive_system0.65873843
118MP0003634_abnormal_glial_cell0.64234564
119MP0000762_abnormal_tongue_morphology0.63139564
120MP0003638_abnormal_response/metabolism_0.63016835
121MP0002272_abnormal_nervous_system0.62970306
122MP0005330_cardiomyopathy0.62687858
123MP0008775_abnormal_heart_ventricle0.62417493
124MP0002277_abnormal_respiratory_mucosa0.61987829
125MP0002733_abnormal_thermal_nociception0.60659634
126MP0002249_abnormal_larynx_morphology0.59608379
127MP0005390_skeleton_phenotype0.56656492
128MP0002998_abnormal_bone_remodeling0.56219746
129MP0002108_abnormal_muscle_morphology0.53508836
130MP0004134_abnormal_chest_morphology0.52997041
131MP0000049_abnormal_middle_ear0.52304110
132MP0000266_abnormal_heart_morphology0.52201198
133MP0001784_abnormal_fluid_regulation0.51900538

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)6.87763847
2Polycythemia (HP:0001901)6.77612389
3Spontaneous hematomas (HP:0007420)6.61619909
4Interstitial pulmonary disease (HP:0006530)4.78750209
5Abnormality of the nasal mucosa (HP:0000433)4.68487814
6Conjunctival telangiectasia (HP:0000524)4.06132685
7Hyperactive renin-angiotensin system (HP:0000841)4.05081696
8Visceral angiomatosis (HP:0100761)3.84545282
9Facial shape deformation (HP:0011334)3.84365423
10Potter facies (HP:0002009)3.84365423
11Aplasia involving bones of the extremities (HP:0009825)3.80028693
12Aplasia involving bones of the upper limbs (HP:0009823)3.80028693
13Aplasia of the phalanges of the hand (HP:0009802)3.80028693
14Cerebral hemorrhage (HP:0001342)3.79573249
15Esophageal varix (HP:0002040)3.71915036
16Hypoplastic left heart (HP:0004383)3.57943982
17Pulmonary artery stenosis (HP:0004415)3.53191451
18Hemangiomatosis (HP:0007461)3.51097357
19Broad metatarsal (HP:0001783)3.44894776
20Abnormality of the vasculature of the conjunctiva (HP:0008054)3.29791886
21Glomerulonephritis (HP:0000099)3.29449949
22Neurofibrillary tangles (HP:0002185)3.27880865
23Vascular tortuosity (HP:0004948)3.14179412
24Chronic bronchitis (HP:0004469)3.07362996
25Amyloidosis (HP:0011034)2.98063015
26Short hallux (HP:0010109)2.97356033
27Complement deficiency (HP:0004431)2.89917064
28Atrioventricular block (HP:0001678)2.84610335
29Arterial tortuosity (HP:0005116)2.82485185
30Abnormality of the ischium (HP:0003174)2.80204071
31Anomalous pulmonary venous return (HP:0010772)2.77153375
32Cerebral aneurysm (HP:0004944)2.75106043
33Abnormality of the 4th metacarpal (HP:0010012)2.74180441
34Systemic lupus erythematosus (HP:0002725)2.73139175
35Adactyly (HP:0009776)2.73034437
36Abnormality of the fingertips (HP:0001211)2.70475758
37Humeroradial synostosis (HP:0003041)2.66816093
38Synostosis involving the elbow (HP:0003938)2.66816093
39Growth hormone excess (HP:0000845)2.65137885
40Aplasia/Hypoplasia of the hallux (HP:0008362)2.64876281
41Cavernous hemangioma (HP:0001048)2.63251991
42Pulmonary hypertension (HP:0002092)2.62707327
43Bladder diverticulum (HP:0000015)2.61171988
44Hypoplasia of the iris (HP:0007676)2.57157613
45Hypoplastic heart (HP:0001961)2.56448973
46Portal hypertension (HP:0001409)2.55793545
47Aortic aneurysm (HP:0004942)2.51363716
48Myotonia (HP:0002486)2.49426442
49Aortic valve stenosis (HP:0001650)2.45744315
50Obstructive sleep apnea (HP:0002870)2.43376644
51Striae distensae (HP:0001065)2.39324505
52Microcytic anemia (HP:0001935)2.38481351
53Mesangial abnormality (HP:0001966)2.35383882
54Onycholysis (HP:0001806)2.34552580
55Overgrowth (HP:0001548)2.31035113
56Renal salt wasting (HP:0000127)2.29932980
57Abnormality of complement system (HP:0005339)2.26927863
58Cerebral inclusion bodies (HP:0100314)2.26644480
59Camptodactyly of toe (HP:0001836)2.25970712
60Deep venous thrombosis (HP:0002625)2.25878690
61Annular pancreas (HP:0001734)2.24302464
62Mitral valve prolapse (HP:0001634)2.23815911
63Abnormality of the hepatic vasculature (HP:0006707)2.23417413
64Tubulointerstitial fibrosis (HP:0005576)2.22500348
65Nephritis (HP:0000123)2.20892902
66Aortic dissection (HP:0002647)2.19736524
67Lymphangioma (HP:0100764)2.18509385
68Neoplasm of the heart (HP:0100544)2.18356880
69Action tremor (HP:0002345)2.18244284
70Turricephaly (HP:0000262)2.17788779
71Redundant skin (HP:0001582)2.16573208
72Abnormal umbilical cord blood vessels (HP:0011403)2.16542712
73Single umbilical artery (HP:0001195)2.16542712
74Abnormality of the fetal cardiovascular system (HP:0010948)2.16542712
75Mucosal telangiectasiae (HP:0100579)2.15347487
76Abnormality of the pulmonary veins (HP:0011718)2.14975821
77Hyperaldosteronism (HP:0000859)2.14331529
78Respiratory distress (HP:0002098)2.13679014
79Intestinal atresia (HP:0011100)2.12228247
80Bronchomalacia (HP:0002780)2.12098515
81Venous insufficiency (HP:0005293)2.11063416
82Segmental peripheral demyelination/remyelination (HP:0003481)2.10836094
83Hyperkalemia (HP:0002153)2.10462781
84Cerebral palsy (HP:0100021)2.09748679
85Muscle fiber splitting (HP:0003555)2.09695053
86Wormian bones (HP:0002645)2.07471997
87Shallow orbits (HP:0000586)2.07104363
88Megalencephaly (HP:0001355)2.05278590
89Protrusio acetabuli (HP:0003179)2.04613335
90Hydroureter (HP:0000072)2.03663156
91Midline defect of the nose (HP:0004122)2.01808393
92Spinal rigidity (HP:0003306)2.01703230
93Narrow nasal bridge (HP:0000446)2.01676728
94Venous abnormality (HP:0002624)2.00804828
95Myocardial infarction (HP:0001658)1.98792257
96Absent toe (HP:0010760)1.98128211
97Round ear (HP:0100830)1.97633279
98Absent hand (HP:0004050)1.97433127
99Hemiplegia (HP:0002301)1.90492598
100Short 4th metacarpal (HP:0010044)1.89852774
101Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89852774
102Glucose intolerance (HP:0000833)1.89794849
103Dilatation of the ascending aorta (HP:0005111)1.89122090
104Osteolytic defects of the phalanges of the hand (HP:0009771)1.88386995
105Osteolytic defects of the hand bones (HP:0009699)1.88386995
106Hypercortisolism (HP:0001578)1.87078544
107Short palpebral fissure (HP:0012745)1.85525542
108Split foot (HP:0001839)1.84221873
109Increased variability in muscle fiber diameter (HP:0003557)1.84204196
110Long clavicles (HP:0000890)1.83861206
111Vertebral arch anomaly (HP:0008438)1.83830136
112Alveolar cell carcinoma (HP:0006519)1.83281452
113Mitral regurgitation (HP:0001653)1.82048401
114Hyperextensible skin (HP:0000974)1.81821883
115Aplasia cutis congenita (HP:0001057)1.80086185
116Abnormality of the anterior chamber (HP:0000593)1.79864162
117Rapidly progressive (HP:0003678)1.79708796
118Tachypnea (HP:0002789)1.79662363
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79031896
120Abnormal atrioventricular conduction (HP:0005150)1.79027494
121Pulmonary embolism (HP:0002204)1.78701817
122Abnormal cortical bone morphology (HP:0003103)1.78489435
123Ectopia lentis (HP:0001083)1.77619816
124Shawl scrotum (HP:0000049)1.77171477
125Laryngomalacia (HP:0001601)1.76976933
126Heart block (HP:0012722)1.76762137
127Soft skin (HP:0000977)1.76439304
128Premature rupture of membranes (HP:0001788)1.76226944
129Abnormality of the middle phalanges of the toes (HP:0010183)1.75701087
130Increased circulating renin level (HP:0000848)1.75592011
131Neoplasm of the tracheobronchial system (HP:0100552)1.75179543
132Back pain (HP:0003418)1.74650995
133Disproportionate tall stature (HP:0001519)1.73521688
134Follicular hyperkeratosis (HP:0007502)1.73125027
135Ulnar claw (HP:0001178)1.72945490
136Hypokalemic alkalosis (HP:0001949)1.72549895
137Broad ribs (HP:0000885)1.71334745
138Thin ribs (HP:0000883)1.71226263
139Decreased circulating renin level (HP:0003351)1.70742248
140Polar cataract (HP:0010696)1.70022645
141Mitral stenosis (HP:0001718)1.69068323
142Blue sclerae (HP:0000592)1.68587448
143Increased CSF protein (HP:0002922)1.68240941
144Joint contractures involving the joints of the feet (HP:0100492)1.67736230
145Flexion contracture of toe (HP:0005830)1.67736230
146Hyporeflexia of lower limbs (HP:0002600)1.67607086
147Hypotension (HP:0002615)1.66840574
148Abnormality of skeletal muscle fiber size (HP:0012084)1.66800717
149Pulmonic stenosis (HP:0001642)1.66760651
150Cutaneous finger syndactyly (HP:0010554)1.66637491
151Ankle contracture (HP:0006466)1.66276625
152Supernumerary nipples (HP:0002558)1.65236456
153Skull defect (HP:0001362)1.65233651
154Intestinal polyposis (HP:0200008)1.65141214
155Tubulointerstitial abnormality (HP:0001969)1.63939195
156Tarsal synostosis (HP:0008368)1.63677323
157Stroke (HP:0001297)1.62395910
158Eczematoid dermatitis (HP:0000976)1.62188951
159Abnormality of renin-angiotensin system (HP:0000847)1.61341646
160Wrist flexion contracture (HP:0001239)1.61282314
161J-shaped sella turcica (HP:0002680)1.59397327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.40511779
2TGFBR25.14581660
3CASK4.04927387
4MARK12.42347738
5NTRK32.40648598
6PDGFRA2.28827832
7EPHB22.20464823
8PHKG22.02297755
9PHKG12.02297755
10GRK12.02124981
11TGFBR11.92163338
12LMTK21.84916899
13AKT31.64515016
14FER1.63309673
15TRIB31.55833454
16STK38L1.53610001
17MYLK1.46696447
18MARK21.40173185
19KDR1.39030347
20EPHA31.32235724
21GRK71.29820574
22PTK2B1.27900475
23MAPK121.27141224
24STK241.26637846
25PRKD31.22567189
26EPHB11.22519515
27FGFR41.22175160
28NTRK11.21217680
29PTK61.16709136
30MAP2K31.15643557
31CSK1.13834575
32LRRK21.13047302
33RIPK11.08694522
34LATS11.08580393
35GRK51.08414886
36DDR21.04140126
37ERN11.03833592
38STK101.00801119
39PAK41.00219322
40PIK3CA0.98938329
41CAMK2B0.97308443
42NEK60.97047122
43PDGFRB0.94039639
44TNK20.90175677
45PKN10.89678221
46PRPF4B0.88633156
47MAP3K60.87535304
48ILK0.84965778
49EPHA40.84555190
50PDK20.83632335
51FGFR30.83367872
52ADRBK10.83288485
53SGK20.81932766
54PRKCH0.80796106
55FGFR20.75812743
56TTN0.75581349
57MATK0.75560960
58SGK2230.73789700
59SGK4940.73789700
60PRKCE0.73471617
61RPS6KA20.72253591
62BCR0.70351258
63MAP3K70.69456078
64PRKD10.67594939
65MAPK40.67477494
66CAMK1G0.67313532
67SGK30.66402388
68RET0.63862200
69DMPK0.62275375
70KSR20.61817717
71MAP2K40.61328236
72UHMK10.60746799
73ICK0.60617003
74CAMK2G0.60333721
75MAPK70.59335187
76EEF2K0.57629135
77ROCK10.57408839
78MAPK100.56136416
79NTRK20.54247878
80MAP2K10.53852882
81ROCK20.52010449
82BMX0.51709306
83MAP3K30.51500271
84CAMK2A0.49466340
85INSR0.49432415
86TRPM70.49173200
87IGF1R0.47973742
88GSK3A0.47740672
89STK380.47470921
90FES0.47334287
91EIF2AK20.47003401
92CDC42BPA0.46115764
93MTOR0.45998399
94PRKG10.45519809
95SRC0.45080372
96MAPK150.44747399
97DAPK20.44708782
98PAK20.44616438
99TESK10.44272315
100MAP3K130.43854133
101MOS0.43093873
102EGFR0.41756296
103PLK20.41744606
104ERBB40.41690165
105ABL20.39926943
106DYRK1A0.39640102
107CAMK40.37874353
108SGK10.37569265
109NEK90.36512562
110MAP3K20.36397961
111CAMK2D0.36083370
112MAPK30.35652938
113MINK10.34849741
114YES10.34758361
115PAK30.34133453
116PRKAA20.33500351
117FGR0.33283108
118PRKCQ0.33102205
119MAPK130.32602316
120PDPK10.32467217
121LATS20.32066333
122MAP2K20.32050513
123MAP2K60.30948620
124PRKG20.29838648
125NLK0.29747212
126MKNK20.29628380
127MST40.29582774
128SIK10.29454693
129TNIK0.29372945
130TYRO30.28992109
131MET0.28197325
132JAK10.27566351
133TBK10.26424450
134MAP3K120.25369806
135SIK30.24994886
136LIMK10.24880154
137PINK10.24157361
138PTK20.24089399
139IRAK10.24013155
140KIT0.22411053

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.39575510
2ECM-receptor interaction_Homo sapiens_hsa045122.28168763
3Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.07247174
4AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.97160879
5Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.93552549
6Notch signaling pathway_Homo sapiens_hsa043301.85322268
7Focal adhesion_Homo sapiens_hsa045101.78411055
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.77422830
9Malaria_Homo sapiens_hsa051441.65280812
10Renin secretion_Homo sapiens_hsa049241.61907895
11Dilated cardiomyopathy_Homo sapiens_hsa054141.58589973
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55306358
13Fatty acid biosynthesis_Homo sapiens_hsa000611.51893790
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.48085431
15Complement and coagulation cascades_Homo sapiens_hsa046101.45584604
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41814219
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41668549
18Histidine metabolism_Homo sapiens_hsa003401.40269472
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.39580219
20Adherens junction_Homo sapiens_hsa045201.37162268
21Rap1 signaling pathway_Homo sapiens_hsa040151.37154506
22Salivary secretion_Homo sapiens_hsa049701.31436671
23Taste transduction_Homo sapiens_hsa047421.31012515
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24830796
25TGF-beta signaling pathway_Homo sapiens_hsa043501.23228467
26Axon guidance_Homo sapiens_hsa043601.23022345
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17198767
28Gap junction_Homo sapiens_hsa045401.16634789
29Gastric acid secretion_Homo sapiens_hsa049711.15071081
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14969481
31Tight junction_Homo sapiens_hsa045301.13101007
32beta-Alanine metabolism_Homo sapiens_hsa004101.12743926
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11659338
34Fatty acid degradation_Homo sapiens_hsa000711.08140565
35Melanogenesis_Homo sapiens_hsa049161.06263605
36African trypanosomiasis_Homo sapiens_hsa051431.05822265
37Mineral absorption_Homo sapiens_hsa049781.04630663
38Choline metabolism in cancer_Homo sapiens_hsa052311.04545035
39Proteoglycans in cancer_Homo sapiens_hsa052051.03305651
40Fatty acid metabolism_Homo sapiens_hsa012121.02678391
41Dorso-ventral axis formation_Homo sapiens_hsa043201.00893189
42Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98580647
43Bile secretion_Homo sapiens_hsa049760.97497828
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96637317
45Platelet activation_Homo sapiens_hsa046110.94628366
46Long-term depression_Homo sapiens_hsa047300.94525926
47Hippo signaling pathway_Homo sapiens_hsa043900.92319318
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.90731268
49Calcium signaling pathway_Homo sapiens_hsa040200.90067280
50Prion diseases_Homo sapiens_hsa050200.88701773
51cAMP signaling pathway_Homo sapiens_hsa040240.88598925
52Chronic myeloid leukemia_Homo sapiens_hsa052200.88486539
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86909134
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85892749
55Protein digestion and absorption_Homo sapiens_hsa049740.85787440
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.85177918
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84992787
58Thyroid hormone synthesis_Homo sapiens_hsa049180.84298136
59Amoebiasis_Homo sapiens_hsa051460.83508763
60Melanoma_Homo sapiens_hsa052180.83316336
61Lysosome_Homo sapiens_hsa041420.83003769
62Basal cell carcinoma_Homo sapiens_hsa052170.82916030
63ABC transporters_Homo sapiens_hsa020100.82156555
64MicroRNAs in cancer_Homo sapiens_hsa052060.80587094
65Caffeine metabolism_Homo sapiens_hsa002320.80580035
66Tryptophan metabolism_Homo sapiens_hsa003800.79955418
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79851147
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79733853
69GABAergic synapse_Homo sapiens_hsa047270.79644628
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77971394
71Pertussis_Homo sapiens_hsa051330.77544708
72Sphingolipid metabolism_Homo sapiens_hsa006000.77304970
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76900048
74Insulin secretion_Homo sapiens_hsa049110.76172154
75Pathways in cancer_Homo sapiens_hsa052000.74552360
76Vitamin digestion and absorption_Homo sapiens_hsa049770.74433017
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73866016
78AMPK signaling pathway_Homo sapiens_hsa041520.73777562
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.73328046
80Colorectal cancer_Homo sapiens_hsa052100.73291834
81Pancreatic cancer_Homo sapiens_hsa052120.72940158
82Morphine addiction_Homo sapiens_hsa050320.72799183
83Glutamatergic synapse_Homo sapiens_hsa047240.72577346
84PPAR signaling pathway_Homo sapiens_hsa033200.71088500
85Ras signaling pathway_Homo sapiens_hsa040140.70478136
86Renin-angiotensin system_Homo sapiens_hsa046140.70036032
87Endometrial cancer_Homo sapiens_hsa052130.70029905
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69074880
89Glycerolipid metabolism_Homo sapiens_hsa005610.68382343
90Circadian entrainment_Homo sapiens_hsa047130.68332904
91Ovarian steroidogenesis_Homo sapiens_hsa049130.68245129
92Rheumatoid arthritis_Homo sapiens_hsa053230.68183209
93Renal cell carcinoma_Homo sapiens_hsa052110.67386471
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66959158
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66874262
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65332444
97Salmonella infection_Homo sapiens_hsa051320.64830028
98GnRH signaling pathway_Homo sapiens_hsa049120.64454001
99Serotonergic synapse_Homo sapiens_hsa047260.64337077
100Estrogen signaling pathway_Homo sapiens_hsa049150.63253993
101Endocytosis_Homo sapiens_hsa041440.63036410
102Long-term potentiation_Homo sapiens_hsa047200.62947304
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61257323
104Wnt signaling pathway_Homo sapiens_hsa043100.61206846
105Toxoplasmosis_Homo sapiens_hsa051450.61181321
106Phagosome_Homo sapiens_hsa041450.61029366
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.59751027
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59381025
109Pancreatic secretion_Homo sapiens_hsa049720.58728316
110Hepatitis C_Homo sapiens_hsa051600.57388085
111mTOR signaling pathway_Homo sapiens_hsa041500.57073167
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.55929381
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55816588
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55574064
115Oxytocin signaling pathway_Homo sapiens_hsa049210.55178487
116Fatty acid elongation_Homo sapiens_hsa000620.54712288
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54374313
118Hedgehog signaling pathway_Homo sapiens_hsa043400.53876087
119Cholinergic synapse_Homo sapiens_hsa047250.53123089
120Phenylalanine metabolism_Homo sapiens_hsa003600.52541392
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52140116
122VEGF signaling pathway_Homo sapiens_hsa043700.52109998
123Viral myocarditis_Homo sapiens_hsa054160.51469535
124Cocaine addiction_Homo sapiens_hsa050300.51235090
125Glioma_Homo sapiens_hsa052140.50261552
126Small cell lung cancer_Homo sapiens_hsa052220.49979723
127MAPK signaling pathway_Homo sapiens_hsa040100.49709417
128Circadian rhythm_Homo sapiens_hsa047100.49601942

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