TMED10P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of peptidyl-threonine phosphorylation (GO:0010801)9.55361170
2eosinophil migration (GO:0072677)9.51177891
3regulation of sister chromatid cohesion (GO:0007063)9.49875021
4regulation of mononuclear cell migration (GO:0071675)9.35668825
5branch elongation of an epithelium (GO:0060602)8.57836813
6negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)8.16430460
7negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)7.87235925
8positive regulation of chromosome segregation (GO:0051984)7.86474465
9L-fucose catabolic process (GO:0042355)7.78282957
10fucose catabolic process (GO:0019317)7.78282957
11L-fucose metabolic process (GO:0042354)7.78282957
12vesicle fusion (GO:0006906)7.66632225
13peptidyl-lysine dimethylation (GO:0018027)7.64461198
14coenzyme A biosynthetic process (GO:0015937)7.22052869
15ribosomal small subunit assembly (GO:0000028)7.11930430
16autophagic vacuole fusion (GO:0000046)7.01455863
17localization within membrane (GO:0051668)6.71098606
18macrophage chemotaxis (GO:0048246)6.51856828
19organ growth (GO:0035265)6.50611872
20axis elongation (GO:0003401)6.47148191
21regulation of beta-amyloid formation (GO:1902003)5.94555114
22regulation of nitric-oxide synthase biosynthetic process (GO:0051769)5.92854889
23establishment of mitotic spindle orientation (GO:0000132)5.86717645
24negative regulation of GTP catabolic process (GO:0033125)5.85460699
25negative regulation of GTPase activity (GO:0034260)5.85460699
26positive regulation of calcium ion import (GO:0090280)5.81616408
27regulation of T cell receptor signaling pathway (GO:0050856)5.56863389
28organelle membrane fusion (GO:0090174)5.54436016
29monocyte chemotaxis (GO:0002548)5.44248447
30protein import into peroxisome matrix (GO:0016558)5.41172961
31acrosome assembly (GO:0001675)5.15826938
32establishment of mitotic spindle localization (GO:0040001)5.14760707
33histone H3-K9 methylation (GO:0051567)5.14638144
34establishment of spindle orientation (GO:0051294)5.11923601
35double-strand break repair via nonhomologous end joining (GO:0006303)5.04109360
36non-recombinational repair (GO:0000726)5.04109360
373-UTR-mediated mRNA stabilization (GO:0070935)4.98427896
38seminiferous tubule development (GO:0072520)4.89689706
39regulation of amyloid precursor protein catabolic process (GO:1902991)4.78296808
40negative regulation of circadian rhythm (GO:0042754)4.76767559
41positive chemotaxis (GO:0050918)4.72250309
42oxidative demethylation (GO:0070989)4.67247691
43detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.67206427
44organelle fusion (GO:0048284)4.65473686
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.63832543
46regulation of stem cell maintenance (GO:2000036)4.60336100
47pantothenate metabolic process (GO:0015939)4.55380397
48purine nucleoside bisphosphate biosynthetic process (GO:0034033)4.54423764
49ribonucleoside bisphosphate biosynthetic process (GO:0034030)4.54423764
50nucleoside bisphosphate biosynthetic process (GO:0033866)4.54423764
51fucose metabolic process (GO:0006004)4.46401328
52regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.41709866
53protein targeting to lysosome (GO:0006622)4.38605840
54establishment of protein localization to vacuole (GO:0072666)4.38605840
55protein targeting to vacuole (GO:0006623)4.38605840
56histone H3-K9 modification (GO:0061647)4.27961137
57regulation of autophagic vacuole assembly (GO:2000785)4.22576133
58regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)4.22246126
59coenzyme A metabolic process (GO:0015936)4.17054493
60fucosylation (GO:0036065)4.15322789
61membrane budding (GO:0006900)4.12603077
62negative regulation of purine nucleotide catabolic process (GO:0033122)4.06871964
63single-organism membrane fusion (GO:0044801)4.03602221
64detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.99153058
65regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.91210866
66negative regulation of nucleotide catabolic process (GO:0030812)3.89608187
67regulation of mammary gland epithelial cell proliferation (GO:0033599)3.80133561
68regulation of cellular amide metabolic process (GO:0034248)3.79992028
69regulation of peptidyl-threonine phosphorylation (GO:0010799)3.78313749
70negative regulation of nucleoside metabolic process (GO:0045978)3.77404389
71establishment of spindle localization (GO:0051293)3.73060774
72vesicle targeting (GO:0006903)3.69367786
73ER to Golgi vesicle-mediated transport (GO:0006888)3.61670425
74regulation of vacuole organization (GO:0044088)3.53918811
75regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.53513718
76imidazole-containing compound metabolic process (GO:0052803)3.53388644
77regulation of calcium ion import (GO:0090279)3.53070795
78protein localization to peroxisome (GO:0072662)3.50643257
79protein targeting to peroxisome (GO:0006625)3.50643257
80establishment of protein localization to peroxisome (GO:0072663)3.50643257
81sodium-independent organic anion transport (GO:0043252)3.46341724
82negative regulation of dendrite morphogenesis (GO:0050774)3.44260347
83DNA integration (GO:0015074)3.43021591
84Golgi transport vesicle coating (GO:0048200)3.38349816
85COPI coating of Golgi vesicle (GO:0048205)3.38349816
86peptidyl-lysine trimethylation (GO:0018023)3.31818150
87cellular senescence (GO:0090398)3.27543754
88preassembly of GPI anchor in ER membrane (GO:0016254)3.26794839
89COPII vesicle coating (GO:0048208)3.26726477
90labyrinthine layer development (GO:0060711)3.26331177
91negative regulation of macroautophagy (GO:0016242)3.26261215
92peroxisomal transport (GO:0043574)3.26087150
93prenylation (GO:0097354)12.6792824
94protein prenylation (GO:0018342)12.6792824
95positive regulation of mitotic sister chromatid separation (GO:1901970)12.1612368
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)12.1612368
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)12.1612368
98negative regulation of Ras GTPase activity (GO:0034261)12.1529586
99eosinophil chemotaxis (GO:0048245)10.5200213
100negative regulation of T cell receptor signaling pathway (GO:0050860)10.1844971

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.65098072
2VDR_22108803_ChIP-Seq_LS180_Human6.20213776
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.69090637
4NOTCH1_21737748_ChIP-Seq_TLL_Human4.32320817
5AR_21572438_ChIP-Seq_LNCaP_Human3.51300080
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.01140271
7SRY_22984422_ChIP-ChIP_TESTIS_Rat2.65749541
8ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.52036591
9ZNF263_19887448_ChIP-Seq_K562_Human2.46376465
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.37642341
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26391557
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.11058042
13YY1_21170310_ChIP-Seq_MESCs_Mouse2.08919971
14GATA1_22025678_ChIP-Seq_K562_Human11.8008510
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.91375798
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91375798
17RXR_22108803_ChIP-Seq_LS180_Human1.86389782
18PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.64814662
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63590814
20BCAT_22108803_ChIP-Seq_LS180_Human1.63536564
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60106963
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60106963
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60106963
24GBX2_23144817_ChIP-Seq_PC3_Human1.57624772
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57164367
26TP53_16413492_ChIP-PET_HCT116_Human1.45419302
27TAF15_26573619_Chip-Seq_HEK293_Human1.43447741
28P53_22127205_ChIP-Seq_FIBROBLAST_Human1.43349998
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.41286753
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37948234
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.31286598
32GATA3_26560356_Chip-Seq_TH1_Human1.30180196
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25792621
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16648069
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15846373
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15255236
37IRF1_19129219_ChIP-ChIP_H3396_Human1.11360792
38GATA1_19941826_ChIP-Seq_K562_Human1.08622456
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07152108
40RUNX_20019798_ChIP-Seq_JUKART_Human1.04781881
41CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03043235
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02050355
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01659609
44JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97868809
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96343982
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95063325
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93820956
48NFE2_27457419_Chip-Seq_LIVER_Mouse0.93410114
49WDR5_24793694_ChIP-Seq_LNCAP_Human0.92669065
50TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90266336
51TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89942554
52ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89610633
53CTCF_21964334_Chip-Seq_Bcells_Human0.89592256
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89236374
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87720770
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85014522
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83807987
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80500288
59EZH2_22144423_ChIP-Seq_EOC_Human0.79763504
60CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79345582
61SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.77467875
62CTBP1_25329375_ChIP-Seq_LNCAP_Human0.76380494
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74316885
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73510285
65CDX2_20551321_ChIP-Seq_CACO-2_Human0.71110380
66RING1B_27294783_Chip-Seq_NPCs_Mouse0.67820244
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.67378540
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66447448
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66174498
70NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66174498
71NR3C1_23031785_ChIP-Seq_PC12_Mouse0.65515116
72TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.65047350
73GATA2_19941826_ChIP-Seq_K562_Human0.64873859
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.64824512
75ZNF274_21170338_ChIP-Seq_K562_Hela0.64655168
76IKZF1_21737484_ChIP-ChIP_HCT116_Human0.64307682
77TP53_22573176_ChIP-Seq_HFKS_Human0.63940690
78SMC1_22415368_ChIP-Seq_MEFs_Mouse0.63798263
79SOX9_24532713_ChIP-Seq_HFSC_Mouse0.62094896
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.61211905
81FUS_26573619_Chip-Seq_HEK293_Human0.60398895
82REST_18959480_ChIP-ChIP_MESCs_Mouse0.59634721
83P300_19829295_ChIP-Seq_ESCs_Human0.59538226
84OCT1_27270436_Chip-Seq_PROSTATE_Human0.58927836
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.57984419
86TCF4_22108803_ChIP-Seq_LS180_Human0.57191511
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.56707123
88GATA3_21867929_ChIP-Seq_TH1_Mouse0.56348919
89PIAS1_25552417_ChIP-Seq_VCAP_Human0.54637919
90GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.54565243
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.54492231
92PU1_27457419_Chip-Seq_LIVER_Mouse0.54255725
93LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.53562249
94FOXH1_21741376_ChIP-Seq_ESCs_Human0.53553365
95SMC3_22415368_ChIP-Seq_MEFs_Mouse0.53273433
96EP300_21415370_ChIP-Seq_HL-1_Mouse0.52734007
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.51485624
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.51198891
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.51164717
100HTT_18923047_ChIP-ChIP_STHdh_Human0.50876032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation9.98784569
2MP0006082_CNS_inflammation5.30547393
3MP0001664_abnormal_digestion3.38537532
4MP0000467_abnormal_esophagus_morphology3.34282778
5MP0001663_abnormal_digestive_system3.22438590
6MP0003115_abnormal_respiratory_system2.63140852
7MP0001919_abnormal_reproductive_system2.60708839
8MP0000383_abnormal_hair_follicle2.52234964
9MP0005381_digestive/alimentary_phenotyp2.49885667
10MP0002751_abnormal_autonomic_nervous2.43596153
11MP0000566_synostosis12.9228272
12MP0001915_intracranial_hemorrhage1.81153681
13MP0001545_abnormal_hematopoietic_system1.75204160
14MP0005397_hematopoietic_system_phenotyp1.75204160
15MP0000534_abnormal_ureter_morphology1.74679317
16MP0002876_abnormal_thyroid_physiology1.73111037
17MP0005166_decreased_susceptibility_to1.71829975
18MP0010678_abnormal_skin_adnexa1.66638090
19MP0005389_reproductive_system_phenotype1.63924031
20MP0003937_abnormal_limbs/digits/tail_de1.59041564
21MP0003453_abnormal_keratinocyte_physiol1.50978648
22MP0000428_abnormal_craniofacial_morphol1.48938862
23MP0005076_abnormal_cell_differentiation1.42458778
24MP0000858_altered_metastatic_potential1.15739781
25MP0005501_abnormal_skin_physiology1.14547522
26MP0001286_abnormal_eye_development1.05281449
27MP0001293_anophthalmia1.02838973
28MP0000490_abnormal_crypts_of0.99097420
29MP0003763_abnormal_thymus_physiology0.97730783
30MP0003942_abnormal_urinary_system0.97054095
31MP0002109_abnormal_limb_morphology0.91023705
32MP0008004_abnormal_stomach_pH0.90496722
33MP0002115_abnormal_skeleton_extremities0.90097302
34MP0003329_amyloid_beta_deposits0.89380890
35MP0002019_abnormal_tumor_incidence0.88777792
36MP0000470_abnormal_stomach_morphology0.88411728
37MP0005508_abnormal_skeleton_morphology0.82716640
38MP0005023_abnormal_wound_healing0.76566026
39MP0001764_abnormal_homeostasis0.75393297
40MP0010155_abnormal_intestine_physiology0.74633535
41MP0009763_increased_sensitivity_to0.72998133
42MP0005197_abnormal_uvea_morphology0.70409922
43MP0000026_abnormal_inner_ear0.68435677
44MP0001963_abnormal_hearing_physiology0.67289024
45MP0000358_abnormal_cell_content/0.66600488
46MP0000432_abnormal_head_morphology0.64769918
47MP0000477_abnormal_intestine_morphology0.63574905
48MP0005503_abnormal_tendon_morphology0.63236229
49MP0005275_abnormal_skin_tensile0.61931213
50MP0002405_respiratory_system_inflammati0.61309534
51MP0003011_delayed_dark_adaptation0.60927691
52MP0001175_abnormal_lung_morphology0.60062315
53MP0000604_amyloidosis0.56640862
54MP0003935_abnormal_craniofacial_develop0.55941221
55MP0002113_abnormal_skeleton_development0.55240485
56MP0000681_abnormal_thyroid_gland0.54694951
57MP0009672_abnormal_birth_weight0.54138523
58MP0002184_abnormal_innervation0.48861659
59MP0002210_abnormal_sex_determination0.48691356
60MP0003283_abnormal_digestive_organ0.47355532
61MP0003638_abnormal_response/metabolism_0.44954491
62MP0000163_abnormal_cartilage_morphology0.44474422
63MP0003448_altered_tumor_morphology0.44108464
64MP0002168_other_aberrant_phenotype0.43599030
65MP0005253_abnormal_eye_physiology0.41596492
66MP0000377_abnormal_hair_follicle0.40908547
67MP0003936_abnormal_reproductive_system0.39424281
68MP0008438_abnormal_cutaneous_collagen0.39093641
69MP0000627_abnormal_mammary_gland0.37267785
70MP0005390_skeleton_phenotype0.34767061
71MP0002136_abnormal_kidney_physiology0.33160111
72MP0005391_vision/eye_phenotype0.31706705
73MP0010771_integument_phenotype0.31444606
74MP0002736_abnormal_nociception_after0.31371253
75MP0000343_altered_response_to0.29671796
76MP0005025_abnormal_response_to0.29387179
77MP0000350_abnormal_cell_proliferation0.27556630
78MP0003091_abnormal_cell_migration0.26416201
79MP0003195_calcinosis0.26054671
80MP0002697_abnormal_eye_size0.24756082
81MP0009931_abnormal_skin_appearance0.24106506
82MP0000049_abnormal_middle_ear0.23878120
83MP0001986_abnormal_taste_sensitivity0.22945620
84MP0008058_abnormal_DNA_repair0.21659531
85MP0004197_abnormal_fetal_growth/weight/0.21342910
86MP0003315_abnormal_perineum_morphology0.20504479
87MP0002752_abnormal_somatic_nervous0.20177288
88MP0002116_abnormal_craniofacial_bone0.18276114
89MP0002822_catalepsy0.17621451
90MP0005332_abnormal_amino_acid0.17332161
91MP0004484_altered_response_of0.17201185
92MP0002735_abnormal_chemical_nociception0.16901905
93MP0002081_perinatal_lethality0.15850028
94MP0001968_abnormal_touch/_nociception0.15783834
95MP0002161_abnormal_fertility/fecundity0.14685973
96MP0003279_aneurysm0.14427644
97MP0001119_abnormal_female_reproductive0.14319179
98MP0002092_abnormal_eye_morphology0.14187627
99MP0001958_emphysema0.14090164
100MP0010386_abnormal_urinary_bladder0.13735276

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)9.22846452
2Long foot (HP:0001833)9.09835095
3Abnormality of the renal collecting system (HP:0004742)8.21859414
4Acute lymphatic leukemia (HP:0006721)7.27064702
5Large for gestational age (HP:0001520)7.17113273
6Adactyly (HP:0009776)6.58635312
7Progressive muscle weakness (HP:0003323)6.53822015
8Abnormality of fatty-acid metabolism (HP:0004359)6.10373977
9Hypoplastic pelvis (HP:0008839)6.00797557
10Autoamputation (HP:0001218)5.77417406
11Pulmonary artery stenosis (HP:0004415)5.72065538
12Dry hair (HP:0011359)5.55539112
13Ureteral stenosis (HP:0000071)5.40876818
14Menstrual irregularities (HP:0000858)5.21096815
15Steatorrhea (HP:0002570)5.08671784
16Ureteral obstruction (HP:0006000)5.06761834
17Ureteral duplication (HP:0000073)5.05783577
18Brushfield spots (HP:0001088)4.90572662
19Hypoplastic nipples (HP:0002557)4.89965847
20Abnormal auditory evoked potentials (HP:0006958)4.68220559
21Sudden death (HP:0001699)4.43186108
22Increased number of teeth (HP:0011069)4.40346123
23Reduced subcutaneous adipose tissue (HP:0003758)4.37786703
24Transposition of the great arteries (HP:0001669)4.32146159
25Abnormal connection of the cardiac segments (HP:0011545)4.32146159
26Abnormal ventriculo-arterial connection (HP:0011563)4.32146159
27Severe muscular hypotonia (HP:0006829)3.96441225
28Fat malabsorption (HP:0002630)3.92901074
29Decreased lacrimation (HP:0000633)3.88638439
30Anhidrosis (HP:0000970)3.83344111
31Palmoplantar hyperkeratosis (HP:0000972)3.62819213
32Broad-based gait (HP:0002136)3.59717762
33Abnormality of vision evoked potentials (HP:0000649)3.52101865
34Palmar hyperkeratosis (HP:0010765)3.40883315
35Generalized amyotrophy (HP:0003700)3.31349202
36Decreased muscle mass (HP:0003199)3.24634131
37Broad nasal tip (HP:0000455)3.24375251
38Wide intermamillary distance (HP:0006610)3.20585434
39Polyneuropathy (HP:0001271)3.17218833
40Large hands (HP:0001176)3.12659187
41Myoglobinuria (HP:0002913)3.03378268
42Polymicrogyria (HP:0002126)2.98514203
43Plantar hyperkeratosis (HP:0007556)2.89621872
44Rhabdomyolysis (HP:0003201)2.81077070
45Flat face (HP:0012368)2.70259871
46Steppage gait (HP:0003376)2.65312717
47Purpura (HP:0000979)2.61252368
48Hypoplastic iliac wings (HP:0002866)2.60405098
49Clubbing of toes (HP:0100760)2.59751242
50Epiphyseal stippling (HP:0010655)2.53731982
51Chorioretinal coloboma (HP:0000567)2.52610798
52Thickened calvaria (HP:0002684)2.48934449
53Foot dorsiflexor weakness (HP:0009027)2.42345342
54Widely spaced teeth (HP:0000687)2.39346399
55Overfolded helix (HP:0000396)2.32472581
56Basal ganglia calcification (HP:0002135)2.30829388
57Hammertoe (HP:0001765)2.26623570
58Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.22142472
59Abnormality of the foot musculature (HP:0001436)2.21660890
60Posterior embryotoxon (HP:0000627)2.17575177
61Absent toe (HP:0010760)2.17294715
62Abnormally folded helix (HP:0008544)2.11246227
63Abnormality of the line of Schwalbe (HP:0008048)2.09221905
64Anxiety (HP:0000739)2.00897097
65Prenatal maternal abnormality (HP:0002686)2.00345110
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)11.9066907
67Aplasia/Hypoplasia of the nipples (HP:0006709)1.99463421
68Female pseudohermaphroditism (HP:0010458)1.97933062
69Abnormality of the epiphyses of the hand (HP:0005924)1.94957091
70Thickened nuchal skin fold (HP:0000474)1.92580811
71Generalized muscle weakness (HP:0003324)1.89069341
72Decreased motor nerve conduction velocity (HP:0003431)1.87324724
73External ear malformation (HP:0008572)1.84315747
74Spastic tetraplegia (HP:0002510)1.84005563
75Stereotypic behavior (HP:0000733)1.82254358
76Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.81966509
77Short philtrum (HP:0000322)1.81536849
78Abnormal epiphyseal ossification (HP:0010656)1.75497355
79Congenital onset (HP:0003577)1.74906683
80Arterial thrombosis (HP:0004420)1.74436705
81Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.74304485
82Primary adrenal insufficiency (HP:0008207)1.72162370
83Brachycephaly (HP:0000248)1.69882444
84Arthrogryposis multiplex congenita (HP:0002804)1.69630796
85Gangrene (HP:0100758)1.68346290
86Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.62194046
87Hypoplastic ilia (HP:0000946)1.54168570
88Scrotal hypoplasia (HP:0000046)1.51061755
89Underdeveloped supraorbital ridges (HP:0009891)1.49385464
90Venous insufficiency (HP:0005293)1.49160710
91Nail dystrophy (HP:0008404)1.46593653
92Depressed nasal ridge (HP:0000457)1.44893747
93Abnormality of primary teeth (HP:0006481)1.39569003
94Respiratory insufficiency due to muscle weakness (HP:0002747)1.37859222
95Abnormality of the wing of the ilium (HP:0011867)1.35938508
96Webbed neck (HP:0000465)1.35757410
97Pulmonary embolism (HP:0002204)1.35271063
98Opacification of the corneal stroma (HP:0007759)1.28888655
99Freckling (HP:0001480)1.28788600
100Postnatal microcephaly (HP:0005484)1.28752619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK16.72780198
2TAOK25.59007442
3TAOK15.49435220
4MAP2K34.29118354
5MAP3K34.18982926
6MAP3K114.11329260
7JAK32.46619605
8MKNK211.4395323
9ABL21.88384146
10DYRK1A1.76006460
11MAP3K51.40559120
12MAP3K11.08684012
13SRPK10.90933468
14CHEK20.80039685
15MAP3K80.68726924
16PRKCQ0.48150761
17PIK3CG0.22120658
18ABL10.15997286
19INSRR0.15910997
20CSNK1A10.15685426
21IGF1R0.15014367
22DDR20.13940215
23TIE10.13460581
24OBSCN0.11079756
25PRKCD0.07542439
26ADRBK20.06247488
27MYLK0.05415837
28GRK70.04786971
29MUSK0.04639806
30GRK10.04414159
31MAP2K60.03747224
32TTN0.03713211
33PLK40.03290083
34MAP4K20.02791836
35CSNK2A20.02352011
36CSNK2A10.00546022
37ERBB40.00410681
38PRKCA0.00045657
39CSK-0.1249719
40PLK2-0.1213796
41PRKCE-0.1173320
42FES-0.1171150
43IKBKE-0.1167685
44PRKCG-0.1167443
45ITK-0.1151898
46CDK3-0.1141251
47PINK1-0.1138107
48NTRK2-0.1137338
49PRKACG-0.1123779
50LYN-0.1090958
51MAPK4-0.1078368
52TRIM28-0.1060413
53PIK3CA-0.1058425
54EPHA2-0.1054953
55FRK-0.1046655
56MAPK14-0.1030244
57PRKG1-0.1023954
58CAMK2A-0.1020223
59CAMK2G-0.1020190
60CDK2-0.1019099
61MAPK12-0.1004122
62BMX-0.0986081
63PIM1-0.0974814
64BTK-0.0962062
65PASK-0.0927737
66WNK4-0.0904495
67NTRK1-0.0889023
68PKN1-0.0813346
69SYK-0.0809147
70PIM2-0.0784651
71PHKG1-0.0760773
72PHKG2-0.0760773
73KIT-0.0684374
74TAOK3-0.0682577
75GRK6-0.0638013
76PTK2B-0.0629570
77KDR-0.0576145
78NTRK3-0.0552391
79MAP2K4-0.0548122
80LMTK2-0.0532552
81CCNB1-0.0477270
82BLK-0.0427961
83MST1R-0.0419926
84TGFBR2-0.0399389
85WEE1-0.0388257
86GRK5-0.0376058
87TEC-0.0374830
88AKT3-0.0357115
89SIK2-0.0333774
90PRKACA-0.0310144
91ADRBK1-0.0274725
92TXK-0.0210039
93AURKA-0.0209311
94FLT3-0.0191362
95PRKCB-0.0155711
96SRC-0.0137260
97WNK3-0.0106549
98MAPK15-0.0075169
99CSNK1E-0.0048643
100MATK-0.0018932

Predicted pathways (KEGG)

RankGene SetZ-score
1SNARE interactions in vesicular transport_Homo sapiens_hsa041308.77778210
2Pantothenate and CoA biosynthesis_Homo sapiens_hsa007707.26062153
3Taste transduction_Homo sapiens_hsa047423.19718622
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.15833102
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.92751421
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.71259988
7RNA polymerase_Homo sapiens_hsa030202.68854152
8Fatty acid elongation_Homo sapiens_hsa000622.64054317
9Lysine degradation_Homo sapiens_hsa003102.58339478
10Butanoate metabolism_Homo sapiens_hsa006502.39676992
11Amoebiasis_Homo sapiens_hsa051462.06062687
12Glycerolipid metabolism_Homo sapiens_hsa005611.79022642
13beta-Alanine metabolism_Homo sapiens_hsa004101.76201143
14Tryptophan metabolism_Homo sapiens_hsa003801.65836725
15One carbon pool by folate_Homo sapiens_hsa006701.64477449
16Propanoate metabolism_Homo sapiens_hsa006401.41138060
17Proteasome_Homo sapiens_hsa030501.27319793
18Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.18172859
19Fatty acid degradation_Homo sapiens_hsa000711.16756793
20Fatty acid metabolism_Homo sapiens_hsa012121.08575220
21Viral myocarditis_Homo sapiens_hsa054161.08164212
22Complement and coagulation cascades_Homo sapiens_hsa046101.04861278
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01065491
24Glycerophospholipid metabolism_Homo sapiens_hsa005640.87154122
25Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76533591
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74933663
27AMPK signaling pathway_Homo sapiens_hsa041520.71988012
28Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70908438
29MicroRNAs in cancer_Homo sapiens_hsa052060.67159723
30Peroxisome_Homo sapiens_hsa041460.66306354
31Olfactory transduction_Homo sapiens_hsa047400.64536580
32Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64000112
33Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62977850
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61394937
35ECM-receptor interaction_Homo sapiens_hsa045120.59968456
36Epstein-Barr virus infection_Homo sapiens_hsa051690.59360466
37Cholinergic synapse_Homo sapiens_hsa047250.59095232
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59066225
39Choline metabolism in cancer_Homo sapiens_hsa052310.58225601
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57300785
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.55735205
42Malaria_Homo sapiens_hsa051440.54101124
43GnRH signaling pathway_Homo sapiens_hsa049120.54071805
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.53380790
45Salmonella infection_Homo sapiens_hsa051320.52973891
46Nicotine addiction_Homo sapiens_hsa050330.52638318
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48898165
48TNF signaling pathway_Homo sapiens_hsa046680.47300802
49Toxoplasmosis_Homo sapiens_hsa051450.46185782
50Hematopoietic cell lineage_Homo sapiens_hsa046400.44622295
51Caffeine metabolism_Homo sapiens_hsa002320.44515056
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.41736325
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41711238
54Protein digestion and absorption_Homo sapiens_hsa049740.40891111
55Retinol metabolism_Homo sapiens_hsa008300.40802346
56Fatty acid biosynthesis_Homo sapiens_hsa000610.36985186
57Linoleic acid metabolism_Homo sapiens_hsa005910.34103307
58Nitrogen metabolism_Homo sapiens_hsa009100.33805320
59Pyrimidine metabolism_Homo sapiens_hsa002400.33406466
60Arachidonic acid metabolism_Homo sapiens_hsa005900.32225045
61Oxytocin signaling pathway_Homo sapiens_hsa049210.30907910
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30151158
63African trypanosomiasis_Homo sapiens_hsa051430.29522945
64Asthma_Homo sapiens_hsa053100.28432667
65Graft-versus-host disease_Homo sapiens_hsa053320.25902993
66Phagosome_Homo sapiens_hsa041450.25618447
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24723937
68Staphylococcus aureus infection_Homo sapiens_hsa051500.23677152
69Chemical carcinogenesis_Homo sapiens_hsa052040.23441042
70Autoimmune thyroid disease_Homo sapiens_hsa053200.22936079
71Phototransduction_Homo sapiens_hsa047440.21755944
72Allograft rejection_Homo sapiens_hsa053300.21591111
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20808053
74MAPK signaling pathway_Homo sapiens_hsa040100.20544362
75Systemic lupus erythematosus_Homo sapiens_hsa053220.20275186
76Calcium signaling pathway_Homo sapiens_hsa040200.19641019
77Fat digestion and absorption_Homo sapiens_hsa049750.19537335
78RNA transport_Homo sapiens_hsa030130.19426948
79Rap1 signaling pathway_Homo sapiens_hsa040150.19029328
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18778288
81Hedgehog signaling pathway_Homo sapiens_hsa043400.18632320
82Nucleotide excision repair_Homo sapiens_hsa034200.18317945
83Dilated cardiomyopathy_Homo sapiens_hsa054140.18072781
84Tyrosine metabolism_Homo sapiens_hsa003500.17702677
85Purine metabolism_Homo sapiens_hsa002300.17639715
86Influenza A_Homo sapiens_hsa051640.16427717
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15987733
88Tuberculosis_Homo sapiens_hsa051520.15205210
89Ovarian steroidogenesis_Homo sapiens_hsa049130.14748389
90Type I diabetes mellitus_Homo sapiens_hsa049400.14646280
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14181603
92Starch and sucrose metabolism_Homo sapiens_hsa005000.13865688
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.13017907
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.12681519
95Pancreatic secretion_Homo sapiens_hsa049720.11186415
96Bile secretion_Homo sapiens_hsa049760.10776091
97Salivary secretion_Homo sapiens_hsa049700.09879102
98Serotonergic synapse_Homo sapiens_hsa047260.09357063
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.08156448
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.05510045

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