TMED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.75454282
2maturation of SSU-rRNA (GO:0030490)5.10744428
3ribosomal small subunit assembly (GO:0000028)4.95478729
4ribosomal large subunit biogenesis (GO:0042273)4.90573807
5viral transcription (GO:0019083)4.74341948
6translational termination (GO:0006415)4.60638586
7negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.60169602
8ribosomal small subunit biogenesis (GO:0042274)4.58257093
9proteasome assembly (GO:0043248)4.49299793
10DNA deamination (GO:0045006)4.36337023
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.33988221
12cotranslational protein targeting to membrane (GO:0006613)4.27322020
13protein targeting to ER (GO:0045047)4.23678003
14translational elongation (GO:0006414)4.22765509
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.22743914
16protein retention in ER lumen (GO:0006621)4.15112426
17formation of translation preinitiation complex (GO:0001731)4.12606336
18nucleobase biosynthetic process (GO:0046112)4.04317716
19chaperone-mediated protein transport (GO:0072321)4.02530421
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.02440419
21GDP-mannose metabolic process (GO:0019673)4.01655090
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.01429361
23protein localization to endoplasmic reticulum (GO:0070972)4.00887177
24COPI coating of Golgi vesicle (GO:0048205)4.00483158
25Golgi transport vesicle coating (GO:0048200)4.00483158
26DNA strand elongation involved in DNA replication (GO:0006271)3.98483245
27translational initiation (GO:0006413)3.97759985
28L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.96262831
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.93087647
30ribonucleoprotein complex biogenesis (GO:0022613)3.85941604
31purine nucleobase biosynthetic process (GO:0009113)3.84543899
32translation (GO:0006412)3.77801076
33DNA strand elongation (GO:0022616)3.75867772
34ATP synthesis coupled proton transport (GO:0015986)3.72966597
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.72966597
36cullin deneddylation (GO:0010388)3.72852195
37spliceosomal snRNP assembly (GO:0000387)3.69637867
38telomere maintenance via semi-conservative replication (GO:0032201)3.68460307
39DNA replication initiation (GO:0006270)3.66383848
40viral life cycle (GO:0019058)3.65729719
41termination of RNA polymerase III transcription (GO:0006386)3.63472339
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.63472339
43spliceosomal complex assembly (GO:0000245)3.60671794
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59362519
45metallo-sulfur cluster assembly (GO:0031163)3.56956250
46iron-sulfur cluster assembly (GO:0016226)3.56956250
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.56283819
48cellular protein complex disassembly (GO:0043624)3.54245588
49pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.51507155
50base-excision repair, AP site formation (GO:0006285)3.46275202
51protein deneddylation (GO:0000338)3.45606511
52pseudouridine synthesis (GO:0001522)3.39677387
53DNA replication checkpoint (GO:0000076)3.39156640
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38361180
55negative regulation of ligase activity (GO:0051352)3.38361180
56CTP metabolic process (GO:0046036)3.38240555
57CTP biosynthetic process (GO:0006241)3.38240555
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.38228397
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34662407
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32156030
61polyamine biosynthetic process (GO:0006596)3.31265882
62protein targeting to mitochondrion (GO:0006626)3.30187861
63establishment of integrated proviral latency (GO:0075713)3.30069160
64viral mRNA export from host cell nucleus (GO:0046784)3.29704132
65UTP metabolic process (GO:0046051)3.28634570
66amyloid precursor protein catabolic process (GO:0042987)3.28094793
67ribosome biogenesis (GO:0042254)3.26542209
68establishment of viral latency (GO:0019043)3.26378961
69pyrimidine nucleotide catabolic process (GO:0006244)3.26060774
70pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.25945180
71rRNA processing (GO:0006364)3.25467280
72cellular component biogenesis (GO:0044085)3.25406255
73L-methionine biosynthetic process (GO:0071265)3.25077642
74amino acid salvage (GO:0043102)3.25077642
75L-methionine salvage (GO:0071267)3.25077642
76deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24241105
77CENP-A containing nucleosome assembly (GO:0034080)3.23002292
78peptidyl-arginine omega-N-methylation (GO:0035247)3.20725428
79heme biosynthetic process (GO:0006783)3.20189730
80mitotic nuclear envelope reassembly (GO:0007084)3.19459789
81nuclear envelope reassembly (GO:0031468)3.19459789
82chromatin remodeling at centromere (GO:0031055)3.18317450
83galactose catabolic process (GO:0019388)3.15843325
84peptidyl-histidine modification (GO:0018202)3.13610562
85pentose-phosphate shunt (GO:0006098)3.13086500
86telomere maintenance via recombination (GO:0000722)3.12224347
87rRNA metabolic process (GO:0016072)3.10815827
88transcription-coupled nucleotide-excision repair (GO:0006283)3.10599553
89protein complex disassembly (GO:0043241)3.10351352
90pentose metabolic process (GO:0019321)3.07816052
91L-serine metabolic process (GO:0006563)3.06368168
92heme metabolic process (GO:0042168)3.06169691
93deoxyribonucleotide catabolic process (GO:0009264)3.05866757
94pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.05169444
95establishment of protein localization to mitochondrion (GO:0072655)3.04923425
96regulation of cellular amino acid metabolic process (GO:0006521)3.03772360
977-methylguanosine mRNA capping (GO:0006370)3.03150310
98L-phenylalanine metabolic process (GO:0006558)3.02567597
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.02567597
100IMP biosynthetic process (GO:0006188)3.02490286
101DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01753537
102RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01088239
103tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01088239
104negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.01032834
105protein complex biogenesis (GO:0070271)3.01007569
106GTP biosynthetic process (GO:0006183)3.00396277
107rRNA modification (GO:0000154)2.98193319
108establishment of protein localization to mitochondrial membrane (GO:0090151)2.97894868
109positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.97509167
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97323908
111oxidative phosphorylation (GO:0006119)2.97030002
112signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96307722
113signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96307722
114signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96307722
115signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96291454
116intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96291454
117macromolecular complex disassembly (GO:0032984)2.95906007
118NADPH regeneration (GO:0006740)2.95321877
1197-methylguanosine RNA capping (GO:0009452)2.94848739
120RNA capping (GO:0036260)2.94848739
121mitotic metaphase plate congression (GO:0007080)2.94440634
122ribosome assembly (GO:0042255)2.94434228
123telomere maintenance via telomere lengthening (GO:0010833)2.93998555
124barbed-end actin filament capping (GO:0051016)2.93814340
125mitochondrial respiratory chain complex assembly (GO:0033108)2.93739167
126UV protection (GO:0009650)2.93086480
127deoxyribose phosphate catabolic process (GO:0046386)2.92519405
128proline biosynthetic process (GO:0006561)2.92115364
129signal transduction involved in DNA damage checkpoint (GO:0072422)2.91430768
130signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91430768
131regulation of mitochondrial translation (GO:0070129)2.90944491
132UTP biosynthetic process (GO:0006228)2.90028261
133transcription from RNA polymerase I promoter (GO:0006360)2.90015839
134folic acid-containing compound biosynthetic process (GO:0009396)2.89688628
135protein localization to mitochondrion (GO:0070585)2.87859269
136guanosine-containing compound biosynthetic process (GO:1901070)2.87583732
137DNA unwinding involved in DNA replication (GO:0006268)2.87371604
138signal transduction involved in cell cycle checkpoint (GO:0072395)2.87363653
139positive regulation of ligase activity (GO:0051351)2.86335290
140histone arginine methylation (GO:0034969)2.85352867
141nucleobase-containing small molecule interconversion (GO:0015949)2.84812214
142mitotic recombination (GO:0006312)2.84174792
143pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.84161752
144regulation of ubiquitin-protein transferase activity (GO:0051438)2.83238653
145nucleotide-excision repair, DNA gap filling (GO:0006297)2.81807500
146mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.80376242
147kinetochore assembly (GO:0051382)2.79972896
148glucose catabolic process (GO:0006007)2.78734763
149polyamine metabolic process (GO:0006595)2.76943523
150DNA damage response, detection of DNA damage (GO:0042769)2.76881063
151mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76825448
152mitochondrial respiratory chain complex I assembly (GO:0032981)2.76825448
153NADH dehydrogenase complex assembly (GO:0010257)2.76825448
154pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.76359307
155nuclear-transcribed mRNA catabolic process (GO:0000956)2.76052932
156kinetochore organization (GO:0051383)2.75772521
157antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75322991
158exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75155618
159regulation of ligase activity (GO:0051340)2.73562916
160respiratory electron transport chain (GO:0022904)2.73352269
161electron transport chain (GO:0022900)2.65968974
162pinocytosis (GO:0006907)2.65810607
163tricarboxylic acid cycle (GO:0006099)2.64436084
164rRNA methylation (GO:0031167)2.64224801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.57133821
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.67994925
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10240504
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91368412
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59778209
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.56128725
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.51599183
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.47129918
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.33078528
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.27504742
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24014756
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14986638
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.04515538
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.84959448
15* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.64855880
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63659262
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58438640
18XRN2_22483619_ChIP-Seq_HELA_Human2.57373819
19* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.50783247
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47292183
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47157754
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41802128
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35387401
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.32814246
25DCP1A_22483619_ChIP-Seq_HELA_Human2.17311844
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12342625
27* VDR_23849224_ChIP-Seq_CD4+_Human2.11891464
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10223224
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.97531117
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96436176
31TTF2_22483619_ChIP-Seq_HELA_Human1.94880034
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.88300721
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88073348
34GABP_19822575_ChIP-Seq_HepG2_Human1.86170117
35ZNF263_19887448_ChIP-Seq_K562_Human1.80950569
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78105290
37* FOXP3_21729870_ChIP-Seq_TREG_Human1.73663064
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73300736
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72436038
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72118730
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70349506
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70315337
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66592153
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66505834
45AR_21909140_ChIP-Seq_LNCAP_Human1.65763452
46ELK1_19687146_ChIP-ChIP_HELA_Human1.64279851
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60983094
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59313770
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55744536
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.54996789
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54844598
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.54626194
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53774206
54* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51821955
55* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49430131
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48019062
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47935270
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46004962
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.44601673
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44564661
61VDR_21846776_ChIP-Seq_THP-1_Human1.40742689
62* LXR_22292898_ChIP-Seq_THP-1_Human1.39871110
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39388274
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.38730574
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38455175
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.38313142
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36889349
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36375160
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36129636
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32767331
71* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28407879
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25296643
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25094420
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23181123
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.22361017
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21683085
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20584971
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19574094
79* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19502987
80* BCL6_27268052_Chip-Seq_Bcells_Human1.18354976
81FOXP1_21924763_ChIP-Seq_HESCs_Human1.18189257
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.17861160
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16355387
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16173036
85CIITA_25753668_ChIP-Seq_RAJI_Human1.15971319
86BP1_19119308_ChIP-ChIP_Hs578T_Human1.15564258
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14980495
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13727586
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13054730
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12558882
91RACK7_27058665_Chip-Seq_MCF-7_Human1.11742722
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11665040
93P68_20966046_ChIP-Seq_HELA_Human1.11030671
94SOX17_20123909_ChIP-Seq_XEN_Mouse1.10895416
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10455555
96KDM5A_27292631_Chip-Seq_BREAST_Human1.10354041
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09651232
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09604830
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08948065
100MYC_18940864_ChIP-ChIP_HL60_Human1.08438022
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08052495
102BCOR_27268052_Chip-Seq_Bcells_Human1.06478252
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06453674
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05957743
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05824531
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05682562
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.04580915
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04266483
109TFEB_21752829_ChIP-Seq_HELA_Human1.03582475
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.02814953
111CTCF_21964334_Chip-Seq_Bcells_Human1.02069970
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01655084
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01494131
114ATF3_27146783_Chip-Seq_COLON_Human1.00846045
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00563338
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00083523
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99698478
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97512194
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97237439
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.96833573
121RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94731368
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92374784
123* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91871819
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90682407
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89133384
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89133384
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89133384
128YY1_22570637_ChIP-Seq_MALME-3M_Human0.86848927
129CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85596712
130* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84486403
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83927191
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82763938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.85083204
2MP0008438_abnormal_cutaneous_collagen3.69158022
3MP0003693_abnormal_embryo_hatching3.47394978
4MP0003806_abnormal_nucleotide_metabolis3.21162273
5MP0005503_abnormal_tendon_morphology3.18801404
6MP0005451_abnormal_body_composition3.09706634
7MP0010030_abnormal_orbit_morphology2.87953177
8MP0004957_abnormal_blastocyst_morpholog2.79492804
9MP0009840_abnormal_foam_cell2.79158991
10MP0003111_abnormal_nucleus_morphology2.56224730
11MP0008932_abnormal_embryonic_tissue2.47029045
12MP0010094_abnormal_chromosome_stability2.40685467
13MP0001661_extended_life_span2.40079173
14MP0009379_abnormal_foot_pigmentation2.34055647
15MP0003077_abnormal_cell_cycle2.31752685
16MP0003123_paternal_imprinting2.22240196
17MP0008007_abnormal_cellular_replicative2.16251076
18MP0003191_abnormal_cellular_cholesterol2.01528537
19MP0004233_abnormal_muscle_weight1.97393031
20MP0005275_abnormal_skin_tensile1.94885321
21MP0004858_abnormal_nervous_system1.92410791
22MP0008058_abnormal_DNA_repair1.91771388
23MP0003186_abnormal_redox_activity1.89417374
24MP0003718_maternal_effect1.82312040
25MP0000343_altered_response_to1.81733594
26MP0000750_abnormal_muscle_regeneration1.81114414
27MP0000749_muscle_degeneration1.80935255
28MP0003279_aneurysm1.80582196
29MP0000049_abnormal_middle_ear1.80077634
30MP0004133_heterotaxia1.75470938
31MP0008260_abnormal_autophagy1.73729232
32MP0004272_abnormal_basement_membrane1.72251173
33MP0004147_increased_porphyrin_level1.68453960
34MP0009697_abnormal_copulation1.66377566
35MP0002877_abnormal_melanocyte_morpholog1.62937554
36MP0000566_synostosis1.61345970
37MP0005257_abnormal_intraocular_pressure1.61114761
38MP0003941_abnormal_skin_development1.58787931
39MP0000681_abnormal_thyroid_gland1.53142078
40MP0000465_gastrointestinal_hemorrhage1.51951122
41MP0001727_abnormal_embryo_implantation1.48759296
42MP0008789_abnormal_olfactory_epithelium1.48139277
43MP0005508_abnormal_skeleton_morphology1.47511923
44MP0008875_abnormal_xenobiotic_pharmacok1.47499578
45MP0009053_abnormal_anal_canal1.45781392
46MP0003786_premature_aging1.42591298
47MP0002653_abnormal_ependyma_morphology1.38536287
48MP0002938_white_spotting1.38528000
49MP0005171_absent_coat_pigmentation1.38421364
50MP0001730_embryonic_growth_arrest1.37658163
51MP0009333_abnormal_splenocyte_physiolog1.36935836
52MP0001764_abnormal_homeostasis1.36860577
53MP0004084_abnormal_cardiac_muscle1.34632728
54MP0009250_abnormal_appendicular_skeleto1.34536804
55MP0003942_abnormal_urinary_system1.33957510
56MP0003567_abnormal_fetal_cardiomyocyte1.32981003
57MP0002111_abnormal_tail_morphology1.30643061
58MP0000762_abnormal_tongue_morphology1.28507170
59MP0000428_abnormal_craniofacial_morphol1.27757733
60MP0003075_altered_response_to1.27015548
61MP0005165_increased_susceptibility_to1.26874644
62MP0000350_abnormal_cell_proliferation1.25554678
63MP0002282_abnormal_trachea_morphology1.24605772
64MP0000372_irregular_coat_pigmentation1.24353487
65MP0005584_abnormal_enzyme/coenzyme_acti1.23796894
66MP0005464_abnormal_platelet_physiology1.20946660
67MP0003136_yellow_coat_color1.20245544
68MP0003937_abnormal_limbs/digits/tail_de1.18821819
69MP0005501_abnormal_skin_physiology1.18463635
70MP0005083_abnormal_biliary_tract1.18397565
71MP0002249_abnormal_larynx_morphology1.17826569
72MP0006036_abnormal_mitochondrial_physio1.17725199
73MP0001697_abnormal_embryo_size1.15562316
74MP0005397_hematopoietic_system_phenotyp1.15369382
75MP0001545_abnormal_hematopoietic_system1.15369382
76MP0009384_cardiac_valve_regurgitation1.14308378
77MP0006054_spinal_hemorrhage1.14091699
78MP0000013_abnormal_adipose_tissue1.13877897
79MP0005408_hypopigmentation1.12633850
80MP0002132_abnormal_respiratory_system1.12119201
81MP0004134_abnormal_chest_morphology1.10928617
82MP0002163_abnormal_gland_morphology1.10875308
83MP0002085_abnormal_embryonic_tissue1.06775120
84MP0003119_abnormal_digestive_system1.06674958
85MP0005380_embryogenesis_phenotype1.06501556
86MP0001672_abnormal_embryogenesis/_devel1.06501556
87MP0005023_abnormal_wound_healing1.06427566
88MP0005330_cardiomyopathy1.06080781
89MP0000747_muscle_weakness1.04894195
90MP0003315_abnormal_perineum_morphology1.04889184
91MP0005332_abnormal_amino_acid1.04245527
92MP0002080_prenatal_lethality1.02344371
93MP0002160_abnormal_reproductive_system1.01784258
94MP0008057_abnormal_DNA_replication1.01272269
95MP0001881_abnormal_mammary_gland1.01206315
96MP0005360_urolithiasis1.00535990
97MP0002932_abnormal_joint_morphology1.00358148
98MP0001243_abnormal_dermal_layer0.98840797
99MP0000003_abnormal_adipose_tissue0.98730524
100MP0003984_embryonic_growth_retardation0.98432744
101MP0006292_abnormal_olfactory_placode0.95658461
102MP0009278_abnormal_bone_marrow0.95642379
103MP0002088_abnormal_embryonic_growth/wei0.95478981
104MP0001542_abnormal_bone_strength0.94884482
105MP0000759_abnormal_skeletal_muscle0.93689212
106MP0000163_abnormal_cartilage_morphology0.93062212
107MP0000358_abnormal_cell_content/0.92685195
108MP0005319_abnormal_enzyme/_coenzyme0.91165275
109MP0003385_abnormal_body_wall0.90690639
110MP0000537_abnormal_urethra_morphology0.89702661
111MP0003011_delayed_dark_adaptation0.88581037
112MP0004197_abnormal_fetal_growth/weight/0.88134944
113MP0006035_abnormal_mitochondrial_morpho0.87588952
114MP0001958_emphysema0.86663612
115MP0002084_abnormal_developmental_patter0.86358416
116MP0005395_other_phenotype0.84389839
117MP0003938_abnormal_ear_development0.84331341
118MP0003656_abnormal_erythrocyte_physiolo0.84013905
119MP0001849_ear_inflammation0.83300994
120MP0005367_renal/urinary_system_phenotyp0.83038962
121MP0000516_abnormal_urinary_system0.83038962
122MP0005499_abnormal_olfactory_system0.82928458
123MP0005394_taste/olfaction_phenotype0.82928458
124MP0003646_muscle_fatigue0.82467423
125MP0002108_abnormal_muscle_morphology0.82282669
126MP0000858_altered_metastatic_potential0.82243294
127MP0002148_abnormal_hypersensitivity_rea0.81723299
128MP0003755_abnormal_palate_morphology0.81523236
129MP0000733_abnormal_muscle_development0.81196426
130MP0001853_heart_inflammation0.80884519
131MP0005670_abnormal_white_adipose0.79976038
132MP0001293_anophthalmia0.79957587
133MP0002127_abnormal_cardiovascular_syste0.79830060
134MP0004036_abnormal_muscle_relaxation0.76041090
135MP0000313_abnormal_cell_death0.75400358
136MP0001905_abnormal_dopamine_level0.75151377
137MP0000751_myopathy0.74672643
138MP0002269_muscular_atrophy0.74357205
139MP0005369_muscle_phenotype0.73932704
140MP0005365_abnormal_bile_salt0.73582500
141MP0002019_abnormal_tumor_incidence0.72357801
142MP0008469_abnormal_protein_level0.72106948
143MP0000534_abnormal_ureter_morphology0.71590293
144MP0001286_abnormal_eye_development0.71403011
145MP0000598_abnormal_liver_morphology0.70929999
146MP0003122_maternal_imprinting0.70794564
147MP0002060_abnormal_skin_morphology0.70786877
148MP0010368_abnormal_lymphatic_system0.70144754
149MP0003221_abnormal_cardiomyocyte_apopto0.69965902
150MP0000678_abnormal_parathyroid_gland0.69687466
151MP0002114_abnormal_axial_skeleton0.68913869
152MP0002116_abnormal_craniofacial_bone0.68445837
153MP0002254_reproductive_system_inflammat0.68217623
154MP0009643_abnormal_urine_homeostasis0.68211852
155MP0000432_abnormal_head_morphology0.67120631
156MP0002086_abnormal_extraembryonic_tissu0.67092861
157MP0002837_dystrophic_cardiac_calcinosis0.66798187
158MP0005197_abnormal_uvea_morphology0.65918869
159MP0003115_abnormal_respiratory_system0.65835932
160MP0005636_abnormal_mineral_homeostasis0.65718697
161MP0000609_abnormal_liver_physiology0.65435542

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)4.27498518
2Reticulocytopenia (HP:0001896)3.84274301
3Abnormality of cells of the erythroid lineage (HP:0012130)3.73135054
4Abnormal number of erythroid precursors (HP:0012131)3.47786427
5Cerebral hypomyelination (HP:0006808)3.45460436
6Breast hypoplasia (HP:0003187)3.35585419
7Abnormal protein glycosylation (HP:0012346)3.32259652
8Abnormal glycosylation (HP:0012345)3.32259652
9Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.32259652
10Abnormal protein N-linked glycosylation (HP:0012347)3.32259652
11Abnormal gallbladder physiology (HP:0012438)3.26088889
12Cholecystitis (HP:0001082)3.26088889
13Abnormality of glycolysis (HP:0004366)3.16892347
14Increased serum pyruvate (HP:0003542)3.16892347
15Carpal bone hypoplasia (HP:0001498)3.15713803
16Ragged-red muscle fibers (HP:0003200)3.14981083
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.02799789
18Macrocytic anemia (HP:0001972)3.00307792
19Acute necrotizing encephalopathy (HP:0006965)3.00259221
20Increased hepatocellular lipid droplets (HP:0006565)2.96007224
21Microretrognathia (HP:0000308)2.94661572
22Irregular epiphyses (HP:0010582)2.92597723
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.90507779
24Mitochondrial inheritance (HP:0001427)2.89073432
25Selective tooth agenesis (HP:0001592)2.83367373
26Premature rupture of membranes (HP:0001788)2.82688959
27Rhabdomyolysis (HP:0003201)2.81885066
28Abnormal mitochondria in muscle tissue (HP:0008316)2.80268850
29Vertebral compression fractures (HP:0002953)2.80009366
30Lipid accumulation in hepatocytes (HP:0006561)2.75428826
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71566988
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71566988
33Increased CSF lactate (HP:0002490)2.70910396
34Birth length less than 3rd percentile (HP:0003561)2.69657403
35Myoglobinuria (HP:0002913)2.69197917
36Hepatocellular necrosis (HP:0001404)2.67781303
37Hepatic necrosis (HP:0002605)2.64742412
38Testicular atrophy (HP:0000029)2.64423751
39Abnormality of the umbilical cord (HP:0010881)2.63051150
40Increased serum lactate (HP:0002151)2.61380974
41Abnormality of the fetal cardiovascular system (HP:0010948)2.60515760
42Abnormal umbilical cord blood vessels (HP:0011403)2.60515760
43Single umbilical artery (HP:0001195)2.60515760
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.54889228
45Abnormality of glycolipid metabolism (HP:0010969)2.54889228
46Abnormality of liposaccharide metabolism (HP:0010968)2.54889228
47Cholelithiasis (HP:0001081)2.53898370
48Acute encephalopathy (HP:0006846)2.52939368
49Protrusio acetabuli (HP:0003179)2.52498741
50Entropion (HP:0000621)2.51586723
51Myopathic facies (HP:0002058)2.51324922
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48253523
53Ileus (HP:0002595)2.45783611
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.40139352
55Oral leukoplakia (HP:0002745)2.39449987
563-Methylglutaconic aciduria (HP:0003535)2.38836033
57Degeneration of anterior horn cells (HP:0002398)2.38564951
58Abnormality of the anterior horn cell (HP:0006802)2.38564951
59Exercise intolerance (HP:0003546)2.37441457
60Opisthotonus (HP:0002179)2.37040828
61Renal Fanconi syndrome (HP:0001994)2.34377621
62Vacuolated lymphocytes (HP:0001922)2.33398945
63Abnormal gallbladder morphology (HP:0012437)2.31777685
64Soft skin (HP:0000977)2.31609486
65Prolonged neonatal jaundice (HP:0006579)2.31499251
66Rough bone trabeculation (HP:0100670)2.31473460
67Cerebral palsy (HP:0100021)2.26976658
68Petechiae (HP:0000967)2.25863884
69Reduced subcutaneous adipose tissue (HP:0003758)2.24732061
70Adrenal hypoplasia (HP:0000835)2.22896699
71Hyperthyroidism (HP:0000836)2.21049518
72Trismus (HP:0000211)2.19771170
73Achilles tendon contracture (HP:0001771)2.19526273
74Increased intramyocellular lipid droplets (HP:0012240)2.15110450
75Hypertensive crisis (HP:0100735)2.12455242
76Dysautonomia (HP:0002459)2.11625888
77Progressive macrocephaly (HP:0004481)2.11055843
78Hepatosplenomegaly (HP:0001433)2.09805737
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08917837
80Dicarboxylic aciduria (HP:0003215)2.08917837
81Thoracic kyphosis (HP:0002942)2.08611972
82Pallor (HP:0000980)2.08516230
83Microvesicular hepatic steatosis (HP:0001414)2.08181830
84Muscle stiffness (HP:0003552)2.07785329
85Hypokinesia (HP:0002375)2.03813270
86Spastic paraparesis (HP:0002313)2.03052271
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.02725844
88Secondary amenorrhea (HP:0000869)2.02433742
89Aplasia/Hypoplasia of the patella (HP:0006498)2.01389942
90Distal lower limb muscle weakness (HP:0009053)2.00320265
91Abnormality of the Achilles tendon (HP:0005109)1.98965187
92Abnormality of the intrinsic pathway (HP:0010989)1.98630952
93Lactic acidosis (HP:0003128)1.98572512
94Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98468274
95Patellar aplasia (HP:0006443)1.98033147
96Multiple enchondromatosis (HP:0005701)1.97918130
97Abnormality of fatty-acid metabolism (HP:0004359)1.95840530
98Progressive muscle weakness (HP:0003323)1.95545864
99Exertional dyspnea (HP:0002875)1.94778976
100Cutaneous melanoma (HP:0012056)1.91812557
101Type I transferrin isoform profile (HP:0003642)1.91386618
102Upper limb muscle weakness (HP:0003484)1.90812144
103Renal salt wasting (HP:0000127)1.90796586
104Patent foramen ovale (HP:0001655)1.90200383
105Respiratory failure (HP:0002878)1.89849101
106Cerebral edema (HP:0002181)1.89356582
107Progressive neurologic deterioration (HP:0002344)1.89239945
108J-shaped sella turcica (HP:0002680)1.87744535
109Hypokalemic alkalosis (HP:0001949)1.86580345
110Increased muscle lipid content (HP:0009058)1.86203092
111Small epiphyses (HP:0010585)1.85612273
112Increased serum ferritin (HP:0003281)1.84874501
113Abnormality of the gallbladder (HP:0005264)1.84175219
114Dysostosis multiplex (HP:0000943)1.82137739
115Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81530921
116Absent epiphyses (HP:0010577)1.81530921
117Lethargy (HP:0001254)1.80825094
118Abnormality of urine glucose concentration (HP:0011016)1.80035478
119Glycosuria (HP:0003076)1.80035478
120Hyponatremia (HP:0002902)1.79308876
121Spinal muscular atrophy (HP:0007269)1.79189716
122Delayed epiphyseal ossification (HP:0002663)1.78643653
123Neonatal short-limb short stature (HP:0008921)1.78076354
124Megaloblastic anemia (HP:0001889)1.77558822
125Exercise-induced muscle cramps (HP:0003710)1.77396954
126Abnormal autonomic nervous system physiology (HP:0012332)1.75968211
127Flat capital femoral epiphysis (HP:0003370)1.75827898
128Abnormality of the distal phalanges of the toes (HP:0010182)1.75242080
129Fatigue (HP:0012378)1.75231984
130Aplasia/hypoplasia of the uterus (HP:0008684)1.74957374
131Epiphyseal stippling (HP:0010655)1.74744872
132Absent radius (HP:0003974)1.74628031
133Emotional lability (HP:0000712)1.74396869
134Spastic diplegia (HP:0001264)1.74233440
135Carpal synostosis (HP:0009702)1.73488130
136Redundant skin (HP:0001582)1.73063120
137Abnormal lung lobation (HP:0002101)1.72880654
138Death in infancy (HP:0001522)1.72452440
139Hypoplastic left heart (HP:0004383)1.72244707
140Generalized amyotrophy (HP:0003700)1.72221322
141Short middle phalanx of the 5th finger (HP:0004220)1.72214038
142Colon cancer (HP:0003003)1.71899374
143Facial cleft (HP:0002006)1.70037638
144Delayed cranial suture closure (HP:0000270)1.69892606
145Sparse eyelashes (HP:0000653)1.69413860
146CNS demyelination (HP:0007305)1.68721500
147Respiratory difficulties (HP:0002880)1.68619476
148Partial duplication of the phalanx of hand (HP:0009999)1.67949131
149Premature ovarian failure (HP:0008209)1.65528365
150Aplasia/hypoplasia of the humerus (HP:0006507)1.65380612
151Abnormalities of placenta or umbilical cord (HP:0001194)1.62675549
152Nemaline bodies (HP:0003798)1.61641636
153Abnormal trabecular bone morphology (HP:0100671)1.61283851
154Hypoplastic pelvis (HP:0008839)1.61168536
155Glossoptosis (HP:0000162)1.60682233
156Unsteady gait (HP:0002317)1.60591170
157Triphalangeal thumb (HP:0001199)1.60255276
158Aplasia involving forearm bones (HP:0009822)1.59927874
159Absent forearm bone (HP:0003953)1.59927874
160Abnormal number of incisors (HP:0011064)1.59907762
161Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59061471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.95855440
2VRK24.84495090
3WEE13.49568758
4TLK13.35581190
5EIF2AK13.23936526
6SRPK12.78578977
7EIF2AK32.68838577
8NME22.68008500
9ARAF2.61544363
10STK162.53022727
11BCKDK2.42420341
12NME12.15228308
13ERN11.95166986
14TESK21.83959139
15SMG11.78666467
16TTK1.77743458
17MKNK11.77354286
18LMTK21.77046288
19ZAK1.74913259
20MAP3K31.71725847
21VRK11.68530971
22PBK1.67432152
23CDC71.54691157
24LIMK11.53107857
25MAP2K31.49191908
26PLK41.47411508
27BRSK21.42638265
28TSSK61.41864952
29STK38L1.40692319
30EPHA21.40291251
31OBSCN1.36955201
32AURKA1.36590199
33RPS6KB21.34461714
34MKNK21.32600322
35PLK11.32474625
36DAPK11.32013103
37RPS6KA41.31746621
38AURKB1.30735325
39MAP3K111.28649457
40DYRK31.24896575
41CSNK1G31.19827600
42PAK41.19433111
43CDK71.17087015
44PIM21.14576009
45ACVR1B1.14249556
46MUSK1.12369432
47NEK11.11965080
48MYLK1.09790601
49PLK31.06173043
50TESK11.05002018
51TBK11.04595318
52INSRR0.98887366
53MAP3K80.96219239
54TGFBR10.95708667
55EIF2AK20.93435169
56BMX0.91957242
57DAPK20.91312878
58DYRK20.91109877
59ILK0.90260504
60KDR0.90053463
61MAPKAPK30.88298540
62CSNK1A1L0.88047935
63ATR0.86516397
64TAOK20.86505231
65TAF10.85946039
66STK240.84233821
67MOS0.83061373
68MAP2K70.78967954
69PAK10.78438959
70PIK3CG0.78099244
71NEK20.75520302
72CSNK2A10.75396748
73PASK0.75318999
74FLT30.74449013
75NUAK10.74365205
76CHEK20.73563205
77BRAF0.73317105
78SCYL20.70653447
79CSNK1G20.69276202
80BRSK10.67306213
81TTN0.66437317
82CSNK1G10.66130209
83TYK20.65517282
84GRK60.63121492
85DAPK30.61587490
86CLK10.61376125
87ABL20.61292638
88CDK80.59226028
89STK100.58891470
90DDR20.58185968
91PTK20.57528832
92CSNK2A20.57353921
93TRIB30.56637448
94BCR0.56626487
95MST1R0.56271149
96PRKCI0.56005709
97STK40.55696674
98LRRK20.54058955
99AKT20.53887879
100EPHB20.50198190
101RPS6KA50.49408441
102RAF10.48272586
103TNIK0.47753283
104CCNB10.45978877
105PDK20.44009523
106CHEK10.42992994
107PRKG20.42031077
108CAMK2G0.41708141
109DYRK1B0.40335769
110ERBB40.40282841
111MAPK110.40055474
112IKBKB0.38982587
113ROCK20.38150460
114MST40.37287983
115IRAK20.36296618
116MET0.36023097
117CDK140.35994133
118PAK20.35415594
119PHKG10.35292390
120PHKG20.35292390
121CDK11A0.35246325
122TRPM70.35173351
123MAPKAPK50.34672428
124TGFBR20.34032922
125MAP3K60.33667203
126TIE10.33326966
127IRAK40.32903344
128IRAK30.32556525
129LATS20.31325944
130MAP2K20.30706422
131ROCK10.30558578
132MAPK150.30407951
133CDK190.30238959
134MAPKAPK20.29263919
135CDK150.29087929
136BMPR1B0.28373622
137ERBB30.28079183
138CDK20.27364370
139IRAK10.26731245
140AKT30.25399111

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.37351320
2Proteasome_Homo sapiens_hsa030503.74066965
3DNA replication_Homo sapiens_hsa030303.69230997
4RNA polymerase_Homo sapiens_hsa030203.40302025
5Mismatch repair_Homo sapiens_hsa034303.19812475
6Spliceosome_Homo sapiens_hsa030402.52340722
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52333820
8Pyrimidine metabolism_Homo sapiens_hsa002402.49965799
9Homologous recombination_Homo sapiens_hsa034402.42097696
10Oxidative phosphorylation_Homo sapiens_hsa001902.41107155
11Parkinsons disease_Homo sapiens_hsa050122.36169233
12Base excision repair_Homo sapiens_hsa034102.34120383
13One carbon pool by folate_Homo sapiens_hsa006702.32388510
14Protein export_Homo sapiens_hsa030602.26645680
15RNA transport_Homo sapiens_hsa030132.13997420
16Nucleotide excision repair_Homo sapiens_hsa034202.09103915
17Huntingtons disease_Homo sapiens_hsa050161.82230488
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80847877
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.76887811
20Cell cycle_Homo sapiens_hsa041101.65409082
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52396836
22Glutathione metabolism_Homo sapiens_hsa004801.49501578
23Basal transcription factors_Homo sapiens_hsa030221.44079542
24RNA degradation_Homo sapiens_hsa030181.40103043
25Alzheimers disease_Homo sapiens_hsa050101.38464687
26Fanconi anemia pathway_Homo sapiens_hsa034601.37040232
27Sulfur relay system_Homo sapiens_hsa041221.36860459
28Folate biosynthesis_Homo sapiens_hsa007901.36107225
29Purine metabolism_Homo sapiens_hsa002301.34730409
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33285937
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31953318
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26262533
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23402474
34Non-homologous end-joining_Homo sapiens_hsa034501.21391981
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20441459
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13407094
37Carbon metabolism_Homo sapiens_hsa012001.11549516
38Biosynthesis of amino acids_Homo sapiens_hsa012301.08740444
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05484614
40Cardiac muscle contraction_Homo sapiens_hsa042601.04387057
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.04118164
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02987284
43Lysosome_Homo sapiens_hsa041421.02918029
44Arachidonic acid metabolism_Homo sapiens_hsa005901.02384527
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.00195775
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99328880
47Selenocompound metabolism_Homo sapiens_hsa004500.99168066
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.98358494
49Fatty acid elongation_Homo sapiens_hsa000620.98126652
50p53 signaling pathway_Homo sapiens_hsa041150.94978964
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93927200
52Arginine and proline metabolism_Homo sapiens_hsa003300.89732273
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88030977
54Fatty acid metabolism_Homo sapiens_hsa012120.84037866
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.81814423
56Basal cell carcinoma_Homo sapiens_hsa052170.81494722
57Vibrio cholerae infection_Homo sapiens_hsa051100.81331876
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79520358
59Metabolic pathways_Homo sapiens_hsa011000.77438575
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77215290
61Propanoate metabolism_Homo sapiens_hsa006400.76414682
62Systemic lupus erythematosus_Homo sapiens_hsa053220.73100344
63Vitamin B6 metabolism_Homo sapiens_hsa007500.72817563
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71344783
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69166939
66Pentose phosphate pathway_Homo sapiens_hsa000300.66542092
67Galactose metabolism_Homo sapiens_hsa000520.66477798
68Epstein-Barr virus infection_Homo sapiens_hsa051690.66143899
69mRNA surveillance pathway_Homo sapiens_hsa030150.66010430
70Pyruvate metabolism_Homo sapiens_hsa006200.65883572
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62944474
72Hedgehog signaling pathway_Homo sapiens_hsa043400.62317907
73Fructose and mannose metabolism_Homo sapiens_hsa000510.57873414
74Arginine biosynthesis_Homo sapiens_hsa002200.55430623
75beta-Alanine metabolism_Homo sapiens_hsa004100.54464453
76Hippo signaling pathway_Homo sapiens_hsa043900.53842778
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53723379
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53418722
79Prion diseases_Homo sapiens_hsa050200.52312642
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51316325
81Sulfur metabolism_Homo sapiens_hsa009200.49397456
82N-Glycan biosynthesis_Homo sapiens_hsa005100.49218618
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48624452
84ECM-receptor interaction_Homo sapiens_hsa045120.48554786
85Chemical carcinogenesis_Homo sapiens_hsa052040.47831022
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47581649
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47164693
88Shigellosis_Homo sapiens_hsa051310.45646189
89TGF-beta signaling pathway_Homo sapiens_hsa043500.45552493
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44889134
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44358381
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43659897
93Fatty acid degradation_Homo sapiens_hsa000710.40210218
94Tyrosine metabolism_Homo sapiens_hsa003500.38662826
95Peroxisome_Homo sapiens_hsa041460.37610876
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.35133544
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34228565
98Steroid biosynthesis_Homo sapiens_hsa001000.33208707
99Thyroid cancer_Homo sapiens_hsa052160.32617026
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31231200
101Retinol metabolism_Homo sapiens_hsa008300.31107460
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28201873
103Vitamin digestion and absorption_Homo sapiens_hsa049770.26508951
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26235921
105Viral carcinogenesis_Homo sapiens_hsa052030.26134306
106Apoptosis_Homo sapiens_hsa042100.23946693
107Other glycan degradation_Homo sapiens_hsa005110.23763920
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23678732
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23264643
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21723549
111Linoleic acid metabolism_Homo sapiens_hsa005910.20908247
112Phenylalanine metabolism_Homo sapiens_hsa003600.20904909
113Bladder cancer_Homo sapiens_hsa052190.20876185
114Small cell lung cancer_Homo sapiens_hsa052220.19426745
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19154956
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19137454
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18834303
118Salmonella infection_Homo sapiens_hsa051320.18659512
119Tight junction_Homo sapiens_hsa045300.18227811
120Oocyte meiosis_Homo sapiens_hsa041140.18140565
121Regulation of autophagy_Homo sapiens_hsa041400.17880999
122Rheumatoid arthritis_Homo sapiens_hsa053230.16072565
123Sphingolipid metabolism_Homo sapiens_hsa006000.14047512
124Starch and sucrose metabolism_Homo sapiens_hsa005000.13107988

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »