TMCO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the monovalent cation:proton antiporter 2 (CPA2) family of transporter proteins. Members of this family typically couple the export of monovalent cations, such as potassium or sodium, to the import of protons across cellular membranes. Mutations in this gene have been identified in patients with a rare inherited vision defect, cornea guttata with anterior polar cataract. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)4.13417261
2positive regulation of osteoblast proliferation (GO:0033690)4.03273940
3L-amino acid import (GO:0043092)3.93530304
4protein K11-linked deubiquitination (GO:0035871)3.91209888
5skin morphogenesis (GO:0043589)3.91104256
6sequestering of extracellular ligand from receptor (GO:0035581)3.88628270
7endodermal cell differentiation (GO:0035987)3.66550814
8amino acid import (GO:0043090)3.66168193
9central nervous system myelination (GO:0022010)3.64108384
10axon ensheathment in central nervous system (GO:0032291)3.64108384
11cellular response to hepatocyte growth factor stimulus (GO:0035729)3.61364966
12response to hepatocyte growth factor (GO:0035728)3.61364966
13collagen fibril organization (GO:0030199)3.58349829
14glycine transport (GO:0015816)3.48263028
15photoreceptor cell differentiation (GO:0046530)3.47584314
16eye photoreceptor cell differentiation (GO:0001754)3.47584314
17lipid translocation (GO:0034204)3.46077782
18phospholipid translocation (GO:0045332)3.46077782
19detection of calcium ion (GO:0005513)3.43340829
20lymphangiogenesis (GO:0001946)3.38815090
21response to parathyroid hormone (GO:0071107)3.33113526
22macroautophagy (GO:0016236)3.26302477
23protein heterotrimerization (GO:0070208)3.23955986
24cellular response to vitamin D (GO:0071305)3.08599429
25bone trabecula formation (GO:0060346)3.08317541
26glycoprotein catabolic process (GO:0006516)3.04942682
27hemidesmosome assembly (GO:0031581)3.04036745
28regulation of hippo signaling (GO:0035330)3.02290136
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.02164495
30endocardial cushion development (GO:0003197)2.98929410
31response to redox state (GO:0051775)2.97313859
32negative regulation of interleukin-8 production (GO:0032717)2.93261061
33wound healing, spreading of epidermal cells (GO:0035313)2.92409536
34response to lipoprotein particle (GO:0055094)2.91979398
35regulation of integrin-mediated signaling pathway (GO:2001044)2.89392638
36type B pancreatic cell development (GO:0003323)2.88532692
37UDP-N-acetylglucosamine metabolic process (GO:0006047)2.86343647
38positive regulation of hair cycle (GO:0042635)2.86294213
39positive regulation of hair follicle development (GO:0051798)2.86294213
40collagen metabolic process (GO:0032963)2.84487337
41superoxide anion generation (GO:0042554)2.82045950
42chondrocyte proliferation (GO:0035988)2.81561658
43neuron cell-cell adhesion (GO:0007158)2.81317487
44glomerular basement membrane development (GO:0032836)2.79741633
45heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.78773234
46keratan sulfate catabolic process (GO:0042340)2.78574418
47collagen catabolic process (GO:0030574)2.78102715
48kidney mesenchyme development (GO:0072074)2.76536969
49retina vasculature morphogenesis in camera-type eye (GO:0061299)2.75793780
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.75718342
51reflex (GO:0060004)2.75009024
52heparan sulfate proteoglycan metabolic process (GO:0030201)2.72763803
53regulation of activation of Janus kinase activity (GO:0010533)2.71652534
54protein localization to endosome (GO:0036010)2.71627848
55cyclic nucleotide catabolic process (GO:0009214)2.71541506
56negative regulation of protein localization to cell surface (GO:2000009)2.70494290
57glycosphingolipid catabolic process (GO:0046479)2.70316723
58protein hydroxylation (GO:0018126)2.69354018
59substrate-dependent cell migration (GO:0006929)2.68937130
60oligosaccharide catabolic process (GO:0009313)2.67805190
61multicellular organismal macromolecule metabolic process (GO:0044259)2.65380935
62vascular endothelial growth factor signaling pathway (GO:0038084)2.64896779
63metanephric mesenchyme development (GO:0072075)2.64783470
64negative regulation of neurotransmitter transport (GO:0051589)2.62952264
65regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.62447508
66smooth muscle tissue development (GO:0048745)2.61731096
67presynaptic membrane organization (GO:0097090)2.60700059
68iron ion import (GO:0097286)2.60285869
69protein targeting to lysosome (GO:0006622)2.60215550
70establishment of protein localization to vacuole (GO:0072666)2.60215550
71protein targeting to vacuole (GO:0006623)2.60215550
72glomerular visceral epithelial cell development (GO:0072015)2.57669698
73regulation of osteoblast proliferation (GO:0033688)2.57547695
74regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.56973288
75extracellular matrix disassembly (GO:0022617)2.56657579
76multicellular organismal metabolic process (GO:0044236)2.56646779
77type B pancreatic cell proliferation (GO:0044342)2.56089460
78multicellular organismal catabolic process (GO:0044243)2.55030796
79nonmotile primary cilium assembly (GO:0035058)2.53277985
80negative regulation of complement activation (GO:0045916)2.51512210
81glomerular epithelial cell development (GO:0072310)2.50834682
82apoptotic cell clearance (GO:0043277)2.49819162
83pericardium development (GO:0060039)2.49115732
84negative regulation of homotypic cell-cell adhesion (GO:0034111)2.48522074
85glycolipid catabolic process (GO:0019377)2.47566905
86ceramide catabolic process (GO:0046514)2.47033544
87presynaptic membrane assembly (GO:0097105)2.45493811
88substrate adhesion-dependent cell spreading (GO:0034446)2.44256141
89cellular response to vitamin (GO:0071295)2.43630269
90oligodendrocyte differentiation (GO:0048709)2.43541763
91basement membrane organization (GO:0071711)2.42126307
92nucleoside diphosphate catabolic process (GO:0009134)2.42063595
93blood vessel maturation (GO:0001955)2.41821697
94angiogenesis involved in wound healing (GO:0060055)2.40737121
95limb bud formation (GO:0060174)2.39249681
96nucleotide transmembrane transport (GO:1901679)2.39172285
97peptidyl-proline hydroxylation (GO:0019511)2.38995783
98hypotonic response (GO:0006971)2.38355923
99endothelial cell proliferation (GO:0001935)2.38188655
100negative regulation of protein activation cascade (GO:2000258)2.36308538
101negative regulation of myoblast differentiation (GO:0045662)2.35877882
102negative regulation of hormone metabolic process (GO:0032351)2.35137994
103phagosome maturation (GO:0090382)2.34905074
104ganglion development (GO:0061548)2.34618822
105negative regulation of hormone biosynthetic process (GO:0032353)2.33609524
106negative regulation of keratinocyte proliferation (GO:0010839)2.33323633
107negative regulation of fatty acid transport (GO:2000192)2.31941640
108dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.31578578
109interleukin-6-mediated signaling pathway (GO:0070102)2.31360184
110positive regulation of vascular permeability (GO:0043117)2.30611981
111regulation of chemokine-mediated signaling pathway (GO:0070099)2.30190501
112extracellular matrix organization (GO:0030198)2.29580857
113extracellular structure organization (GO:0043062)2.28968984
114regulation of timing of cell differentiation (GO:0048505)2.28960995
115cAMP catabolic process (GO:0006198)2.28529836
116paraxial mesoderm development (GO:0048339)2.28354865
117ER overload response (GO:0006983)2.28053158
118righting reflex (GO:0060013)2.27213365
119detection of mechanical stimulus involved in sensory perception (GO:0050974)2.26690458
120desmosome organization (GO:0002934)2.26617488
121cilium or flagellum-dependent cell motility (GO:0001539)2.26192327
122carnitine transmembrane transport (GO:1902603)2.25494050
123sphingoid metabolic process (GO:0046519)2.25150281
124postsynaptic membrane organization (GO:0001941)2.23768469
125cell migration involved in sprouting angiogenesis (GO:0002042)2.22444330
126positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.21955718
127mesenchymal-epithelial cell signaling (GO:0060638)2.20999859
128chondrocyte development (GO:0002063)2.20158737
129positive regulation of calcium ion import (GO:0090280)2.19912340
130COPII vesicle coating (GO:0048208)2.19865192
131cerebral cortex radially oriented cell migration (GO:0021799)2.19148791
132positive regulation of bone mineralization (GO:0030501)2.18768492
133chondroitin sulfate biosynthetic process (GO:0030206)2.18037001
134myelination (GO:0042552)2.17751060
135Golgi transport vesicle coating (GO:0048200)2.17214714
136COPI coating of Golgi vesicle (GO:0048205)2.17214714
137positive regulation of fibroblast migration (GO:0010763)2.16887097
138inner ear receptor cell development (GO:0060119)2.16430283
139mesodermal cell differentiation (GO:0048333)2.15967901
140amino-acid betaine transport (GO:0015838)2.15858498
141carnitine transport (GO:0015879)2.15858498
142regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.14883783
143startle response (GO:0001964)2.14440857
144calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.14418752
145barbed-end actin filament capping (GO:0051016)2.14361969
146cell-substrate junction assembly (GO:0007044)2.14153927
147regulation of fibroblast migration (GO:0010762)2.14030569
148regulation of type B pancreatic cell apoptotic process (GO:2000674)2.13525224
149regulation of homotypic cell-cell adhesion (GO:0034110)2.13231546
150negative regulation of osteoblast proliferation (GO:0033689)2.12562914
151endosome to pigment granule transport (GO:0043485)2.12289698
152endosome to melanosome transport (GO:0035646)2.12289698
153signal peptide processing (GO:0006465)2.12248740
154negative regulation of chondrocyte differentiation (GO:0032331)2.12242707
155lung vasculature development (GO:0060426)2.11858907
156long-chain fatty acid biosynthetic process (GO:0042759)2.11557899
157ensheathment of neurons (GO:0007272)2.11181399
158axon ensheathment (GO:0008366)2.11181399
159heparin biosynthetic process (GO:0030210)2.11144822
160heparin metabolic process (GO:0030202)2.11144822
161positive regulation of vasculogenesis (GO:2001214)2.10154679
162adult walking behavior (GO:0007628)2.10027957
163smoothened signaling pathway (GO:0007224)2.09915571
164dopamine biosynthetic process (GO:0042416)2.09661539
165positive regulation of action potential (GO:0045760)2.08133473
166response to water (GO:0009415)2.08003891
167regulation of platelet aggregation (GO:0090330)2.07845417
168peptide hormone processing (GO:0016486)2.07146141
169negative regulation of neurotransmitter secretion (GO:0046929)2.05543745
170negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.05119478
171positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.04639046
172positive regulation of biomineral tissue development (GO:0070169)2.04338274
173astrocyte differentiation (GO:0048708)2.04018146
174extracellular regulation of signal transduction (GO:1900115)2.03924140
175extracellular negative regulation of signal transduction (GO:1900116)2.03924140
176limb development (GO:0060173)2.02196592
177appendage development (GO:0048736)2.02196592
178response to gravity (GO:0009629)2.01539987
179adhesion of symbiont to host cell (GO:0044650)2.01204110
180virion attachment to host cell (GO:0019062)2.01204110
181calcium ion import (GO:0070509)2.01162218
182cellular response to ATP (GO:0071318)2.01064024
183import into cell (GO:0098657)2.00174909
184glandular epithelial cell development (GO:0002068)1.99718682
185neuronal action potential propagation (GO:0019227)1.95725341
186magnesium ion transport (GO:0015693)1.94057421
187spinal cord motor neuron differentiation (GO:0021522)1.93940675
188response to auditory stimulus (GO:0010996)1.92300152
189eosinophil chemotaxis (GO:0048245)1.91949524
190peripheral nervous system axon ensheathment (GO:0032292)1.91627061
191myelination in peripheral nervous system (GO:0022011)1.91627061
192transferrin transport (GO:0033572)1.91430783
193positive regulation of inositol phosphate biosynthetic process (GO:0060732)1.91167526
194phosphorelay signal transduction system (GO:0000160)1.90485333

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.70394228
2EZH2_22144423_ChIP-Seq_EOC_Human2.48180253
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42802083
4TP53_16413492_ChIP-PET_HCT116_Human2.42764599
5* CJUN_26792858_Chip-Seq_BT549_Human2.38506929
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.36959023
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.26474888
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23179864
9BRD4_25478319_ChIP-Seq_HGPS_Human2.22019227
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22004227
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21854848
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.20309209
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19413728
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16253909
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14656584
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13943087
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05572480
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04912940
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04912940
20GATA2_21666600_ChIP-Seq_HMVEC_Human2.02466339
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98693027
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98149304
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.92608640
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91291355
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85687956
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.82870781
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.78553416
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.76981565
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76718784
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75795207
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74626964
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.73752645
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72852903
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71167015
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69364069
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66060927
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65914201
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.62199650
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.62163658
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61741103
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.60182342
42AR_21572438_ChIP-Seq_LNCaP_Human1.58722049
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58295420
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58095998
45* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56088263
46SMAD4_21799915_ChIP-Seq_A2780_Human1.55064999
47DROSHA_22980978_ChIP-Seq_HELA_Human1.54398471
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52518308
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51658752
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.50151093
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49142160
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48694728
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48121560
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47444419
55P300_19829295_ChIP-Seq_ESCs_Human1.47341760
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46703639
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46175443
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.44949251
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44623471
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.44196580
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43374495
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43367260
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42649178
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42007358
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41493580
66* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41134373
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40700514
68* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40284956
69* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40284956
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40232127
71IGF1R_20145208_ChIP-Seq_DFB_Human1.38463555
72TP63_23658742_ChIP-Seq_EP156T_Human1.36402964
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34981422
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34608718
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34420671
76ER_23166858_ChIP-Seq_MCF-7_Human1.34238798
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33799593
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33661790
79P53_22387025_ChIP-Seq_ESCs_Mouse1.33134585
80* WT1_19549856_ChIP-ChIP_CCG9911_Human1.33116742
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30222929
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.30128874
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29592060
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29045814
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28770949
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.28402073
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.27465839
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27050932
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26600886
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.26525873
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.25873045
92STAT3_23295773_ChIP-Seq_U87_Human1.25268735
93REST_21632747_ChIP-Seq_MESCs_Mouse1.24246072
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23995320
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23800145
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23800145
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22259997
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20424001
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20258132
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19989194
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.19821046
102SOX2_20726797_ChIP-Seq_SW620_Human1.19721976
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.18927757
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.18501477
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18488774
106NMYC_18555785_Chip-Seq_ESCs_Mouse1.18017280
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17410983
108FOXA2_19822575_ChIP-Seq_HepG2_Human1.17163194
109ESR2_21235772_ChIP-Seq_MCF-7_Human1.17126980
110TP53_18474530_ChIP-ChIP_U2OS_Human1.17008737
111LXR_22158963_ChIP-Seq_LIVER_Mouse1.14525258
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14513832
113EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13594581
114RUNX2_22187159_ChIP-Seq_PCA_Human1.13446377
115EP300_21415370_ChIP-Seq_HL-1_Mouse1.12012268
116AHR_22903824_ChIP-Seq_MCF-7_Human1.11829465
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11586881
118AR_25329375_ChIP-Seq_VCAP_Human1.11536529
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11411472
120P300_18555785_Chip-Seq_ESCs_Mouse1.10722905
121TAF15_26573619_Chip-Seq_HEK293_Human1.10590770
122ESR1_21235772_ChIP-Seq_MCF-7_Human1.10371123
123FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10350643
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09209479
125KLF4_18555785_Chip-Seq_ESCs_Mouse1.08182378
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08029432
127PU1_27457419_Chip-Seq_LIVER_Mouse1.07582685
128TCF4_23295773_ChIP-Seq_U87_Human1.06486764
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.06162255
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05954551
131SMAD3_21741376_ChIP-Seq_HESCs_Human1.05394722
132KDM2B_26808549_Chip-Seq_REH_Human1.04460178
133CDX2_22108803_ChIP-Seq_LS180_Human1.04204784
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03646729
135TAL1_26923725_Chip-Seq_HPCs_Mouse1.03478379
136CTCF_18555785_Chip-Seq_ESCs_Mouse1.03105285
137TCF4_18268006_ChIP-ChIP_LS174T_Human1.02549931
138RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01471409
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01442135
140ZFX_18555785_Chip-Seq_ESCs_Mouse1.01371955
141VDR_24787735_ChIP-Seq_THP-1_Human1.00234050
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00229670
143CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99750607
144VDR_22108803_ChIP-Seq_LS180_Human0.99567073
145ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99128298
146BCAT_22108803_ChIP-Seq_LS180_Human0.98788699
147FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98291689
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95360720
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91848464
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.89437231
151SMAD4_21741376_ChIP-Seq_EPCs_Human0.88287888
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86826498
153RXR_22108803_ChIP-Seq_LS180_Human0.86710786
154TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84222553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.56473637
2MP0005645_abnormal_hypothalamus_physiol3.31902738
3MP0000569_abnormal_digit_pigmentation3.28624856
4MP0003279_aneurysm3.21468100
5MP0005275_abnormal_skin_tensile3.14958255
6MP0003705_abnormal_hypodermis_morpholog2.90545605
7MP0010386_abnormal_urinary_bladder2.84697051
8MP0003950_abnormal_plasma_membrane2.78215504
9MP0004043_abnormal_pH_regulation2.60975241
10MP0010368_abnormal_lymphatic_system2.59127182
11MP0003566_abnormal_cell_adhesion2.33590829
12MP0003283_abnormal_digestive_organ2.32115672
13MP0002102_abnormal_ear_morphology2.31129013
14MP0004742_abnormal_vestibular_system2.24875612
15MP0002877_abnormal_melanocyte_morpholog2.23485379
16MP0003195_calcinosis2.23296473
17MP0003183_abnormal_peptide_metabolism2.09856535
18MP0005646_abnormal_pituitary_gland1.97451281
19MP0005171_absent_coat_pigmentation1.97197238
20MP0004270_analgesia1.95053193
21MP0002736_abnormal_nociception_after1.94780237
22MP0003880_abnormal_central_pattern1.86900826
23MP0002734_abnormal_mechanical_nocicepti1.85222981
24MP0002254_reproductive_system_inflammat1.83436096
25MP0003172_abnormal_lysosome_physiology1.81380077
26MP0005423_abnormal_somatic_nervous1.79981686
27MP0009780_abnormal_chondrocyte_physiolo1.78718335
28MP0009840_abnormal_foam_cell1.76516600
29MP0003091_abnormal_cell_migration1.75424855
30MP0000920_abnormal_myelination1.74247697
31MP0008438_abnormal_cutaneous_collagen1.68529124
32MP0002876_abnormal_thyroid_physiology1.68168760
33MP0001299_abnormal_eye_distance/1.68067885
34MP0001968_abnormal_touch/_nociception1.63627092
35MP0001486_abnormal_startle_reflex1.61973745
36MP0001879_abnormal_lymphatic_vessel1.61185347
37MP0001188_hyperpigmentation1.60360916
38MP0000767_abnormal_smooth_muscle1.58218769
39MP0002735_abnormal_chemical_nociception1.56712875
40MP0001542_abnormal_bone_strength1.56705707
41MP0004142_abnormal_muscle_tone1.54745128
42MP0004858_abnormal_nervous_system1.53408860
43MP0002060_abnormal_skin_morphology1.51367874
44MP0001502_abnormal_circadian_rhythm1.49605745
45MP0000678_abnormal_parathyroid_gland1.49350948
46MP0001986_abnormal_taste_sensitivity1.47644936
47MP0005023_abnormal_wound_healing1.46561332
48MP0005503_abnormal_tendon_morphology1.45870397
49MP0005595_abnormal_vascular_smooth1.45778868
50MP0005257_abnormal_intraocular_pressure1.45075373
51MP0001958_emphysema1.44550923
52MP0005623_abnormal_meninges_morphology1.43321531
53MP0009046_muscle_twitch1.42308597
54MP0009384_cardiac_valve_regurgitation1.41961453
55MP0009745_abnormal_behavioral_response1.40086692
56MP0003941_abnormal_skin_development1.39895549
57MP0002272_abnormal_nervous_system1.39256861
58MP0002064_seizures1.39127375
59MP0003191_abnormal_cellular_cholesterol1.37962825
60MP0002295_abnormal_pulmonary_circulatio1.37946273
61MP0001905_abnormal_dopamine_level1.37927790
62MP0003634_abnormal_glial_cell1.37732229
63MP0004134_abnormal_chest_morphology1.37076497
64MP0001970_abnormal_pain_threshold1.36975347
65MP0003635_abnormal_synaptic_transmissio1.36939393
66MP0000778_abnormal_nervous_system1.36379925
67MP0000462_abnormal_digestive_system1.35597293
68MP0005508_abnormal_skeleton_morphology1.35314606
69MP0004859_abnormal_synaptic_plasticity1.33766300
70MP0002067_abnormal_sensory_capabilities1.32398493
71MP0005379_endocrine/exocrine_gland_phen1.32281259
72MP0000013_abnormal_adipose_tissue1.31361068
73MP0000631_abnormal_neuroendocrine_gland1.30453293
74MP0005058_abnormal_lysosome_morphology1.29877576
75MP0001501_abnormal_sleep_pattern1.29859772
76MP0002909_abnormal_adrenal_gland1.27078030
77MP0006072_abnormal_retinal_apoptosis1.26090174
78MP0005164_abnormal_response_to1.25856867
79MP0002733_abnormal_thermal_nociception1.24993620
80MP0003646_muscle_fatigue1.22041152
81MP0000538_abnormal_urinary_bladder1.21525973
82MP0000026_abnormal_inner_ear1.21486334
83MP0001963_abnormal_hearing_physiology1.20788020
84MP0002184_abnormal_innervation1.20029509
85MP0001529_abnormal_vocalization1.19786760
86MP0003122_maternal_imprinting1.15494186
87MP0001346_abnormal_lacrimal_gland1.12127116
88MP0010352_gastrointestinal_tract_polyps1.11963757
89MP0000566_synostosis1.11087168
90MP0002896_abnormal_bone_mineralization1.10108030
91MP0002572_abnormal_emotion/affect_behav1.09842493
92MP0006276_abnormal_autonomic_nervous1.09576730
93MP0000163_abnormal_cartilage_morphology1.09205555
94MP0003045_fibrosis1.07582968
95MP0000371_diluted_coat_color1.06950887
96MP0009250_abnormal_appendicular_skeleto1.06572972
97MP0002837_dystrophic_cardiac_calcinosis1.05061594
98MP0002063_abnormal_learning/memory/cond1.04379375
99MP0002163_abnormal_gland_morphology1.03205224
100MP0004484_altered_response_of1.01744069
101MP0004145_abnormal_muscle_electrophysio1.01056680
102MP0008875_abnormal_xenobiotic_pharmacok0.99890643
103MP0005451_abnormal_body_composition0.99504533
104MP0005551_abnormal_eye_electrophysiolog0.99157445
105MP0001440_abnormal_grooming_behavior0.98502946
106MP0003690_abnormal_glial_cell0.98441114
107MP0003300_gastrointestinal_ulcer0.98403492
108MP0008260_abnormal_autophagy0.97998127
109MP0005310_abnormal_salivary_gland0.97421309
110MP0006082_CNS_inflammation0.96565970
111MP0000003_abnormal_adipose_tissue0.95168859
112MP0000955_abnormal_spinal_cord0.94154444
113MP0005253_abnormal_eye_physiology0.91504749
114MP0002693_abnormal_pancreas_physiology0.90988398
115MP0002557_abnormal_social/conspecific_i0.90546399
116MP0001177_atelectasis0.89530374
117MP0002139_abnormal_hepatobiliary_system0.89492141
118MP0003385_abnormal_body_wall0.89295508
119MP0001664_abnormal_digestion0.89189987
120MP0002933_joint_inflammation0.89111431
121MP0009053_abnormal_anal_canal0.87999191
122MP0001243_abnormal_dermal_layer0.87039578
123MP0001765_abnormal_ion_homeostasis0.86825458
124MP0002168_other_aberrant_phenotype0.85804810
125MP0005197_abnormal_uvea_morphology0.85651299
126MP0002882_abnormal_neuron_morphology0.85536665
127MP0003329_amyloid_beta_deposits0.84602110
128MP0003879_abnormal_hair_cell0.84410220
129MP0005365_abnormal_bile_salt0.84290556
130MP0002115_abnormal_skeleton_extremities0.84257268
131MP0001984_abnormal_olfaction0.83740464
132MP0002277_abnormal_respiratory_mucosa0.83679682
133MP0001614_abnormal_blood_vessel0.83031279
134MP0004272_abnormal_basement_membrane0.82649161
135MP0001485_abnormal_pinna_reflex0.82310457
136MP0002108_abnormal_muscle_morphology0.81624901
137MP0002752_abnormal_somatic_nervous0.80416884
138MP0000604_amyloidosis0.79551662
139MP0002128_abnormal_blood_circulation0.79110507
140MP0003868_abnormal_feces_composition0.78103932
141MP0000534_abnormal_ureter_morphology0.77528390
142MP0010678_abnormal_skin_adnexa0.77451828
143MP0005360_urolithiasis0.76724108
144MP0002998_abnormal_bone_remodeling0.75616843
145MP0005390_skeleton_phenotype0.75430022
146MP0001348_abnormal_lacrimal_gland0.73309696
147MP0005395_other_phenotype0.72539012
148MP0000613_abnormal_salivary_gland0.72227829
149MP0000230_abnormal_systemic_arterial0.70600769
150MP0000383_abnormal_hair_follicle0.70600568
151MP0002971_abnormal_brown_adipose0.69780928
152MP0010234_abnormal_vibrissa_follicle0.69766364
153MP0004233_abnormal_muscle_weight0.69532397
154MP0000428_abnormal_craniofacial_morphol0.68702661
155MP0004883_abnormal_blood_vessel0.68074978
156MP0003942_abnormal_urinary_system0.67985156
157MP0005174_abnormal_tail_pigmentation0.67576026
158MP0000432_abnormal_head_morphology0.67284875
159MP0005408_hypopigmentation0.67209784
160MP0001756_abnormal_urination0.66702238
161MP0005165_increased_susceptibility_to0.65155960
162MP0005409_darkened_coat_color0.64859664
163MP0000015_abnormal_ear_pigmentation0.64298500
164MP0002925_abnormal_cardiovascular_devel0.63585783
165MP0000733_abnormal_muscle_development0.61487812
166MP0003656_abnormal_erythrocyte_physiolo0.58771485
167MP0003252_abnormal_bile_duct0.58667038
168MP0001915_intracranial_hemorrhage0.58500397
169MP0000762_abnormal_tongue_morphology0.56593319

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.98717914
2Aortic dissection (HP:0002647)4.72156354
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.53159448
4Increased circulating renin level (HP:0000848)4.06603801
5Epiphyseal dysplasia (HP:0002656)4.04264530
6Atrophic scars (HP:0001075)4.01446982
7Soft skin (HP:0000977)3.98050558
8Abnormality of calcium-phosphate metabolism (HP:0100530)3.81623659
9Follicular hyperkeratosis (HP:0007502)3.80536770
10Delayed epiphyseal ossification (HP:0002663)3.79704307
11Aortic aneurysm (HP:0004942)3.59067392
12Cervical subluxation (HP:0003308)3.46362479
13Metaphyseal irregularity (HP:0003025)3.45732647
14Hypomagnesemia (HP:0002917)3.42279176
15Ankle contracture (HP:0006466)3.35901082
16Bladder diverticulum (HP:0000015)3.32811995
17Abnormality of polysaccharide metabolism (HP:0011012)3.28208817
18Split foot (HP:0001839)3.22729394
19Broad metatarsal (HP:0001783)3.18875979
20Cardiovascular calcification (HP:0011915)3.18188036
21Mitral stenosis (HP:0001718)3.13239952
22Enlarged epiphyses (HP:0010580)3.07133296
23Wormian bones (HP:0002645)3.06123261
24Peritonitis (HP:0002586)3.05223389
25Fragile skin (HP:0001030)3.04621667
26Spondylolisthesis (HP:0003302)3.03754131
27Congenital sensorineural hearing impairment (HP:0008527)3.02071857
28Tetany (HP:0001281)2.97182257
29Flat capital femoral epiphysis (HP:0003370)2.95686399
30Vertebral compression fractures (HP:0002953)2.84389366
31Polydipsia (HP:0001959)2.79399163
32Abnormal drinking behavior (HP:0030082)2.79399163
33Abnormality of the ischium (HP:0003174)2.79223878
34Metabolic alkalosis (HP:0200114)2.78001416
35Abnormality of magnesium homeostasis (HP:0004921)2.76815393
36Abnormality of renin-angiotensin system (HP:0000847)2.72742455
37Small epiphyses (HP:0010585)2.62799229
38Blue sclerae (HP:0000592)2.56782141
39Vascular calcification (HP:0004934)2.53634221
40Abnormal tarsal ossification (HP:0008369)2.52509802
41Absent frontal sinuses (HP:0002688)2.49107837
42Abnormality of macular pigmentation (HP:0008002)2.48191840
43Irregular epiphyses (HP:0010582)2.47793181
44Genu recurvatum (HP:0002816)2.47625199
45Hyperphosphatemia (HP:0002905)2.46403730
46Hypoplastic ischia (HP:0003175)2.45573369
47Aortic regurgitation (HP:0001659)2.40613144
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39663784
49Mitral valve prolapse (HP:0001634)2.39578356
50Akinesia (HP:0002304)2.36307159
51Ovoid vertebral bodies (HP:0003300)2.33258761
52Long toe (HP:0010511)2.32732058
53Cerebral aneurysm (HP:0004944)2.32550924
54Agitation (HP:0000713)2.32216631
55Hypokalemia (HP:0002900)2.31737032
56Abnormality of the acetabulum (HP:0003170)2.31735303
57Spinal rigidity (HP:0003306)2.31246246
58Polyuria (HP:0000103)2.30100601
59Oligodactyly (hands) (HP:0001180)2.27703323
60Hypothermia (HP:0002045)2.27252788
61Dilatation of the ascending aorta (HP:0005111)2.27060710
62Hyperparathyroidism (HP:0000843)2.26158021
63Vacuolated lymphocytes (HP:0001922)2.25581804
64Osteolytic defects of the hand bones (HP:0009699)2.24528391
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.24528391
66Hypokalemic alkalosis (HP:0001949)2.24120757
67Hyperextensible skin (HP:0000974)2.22480263
68Natal tooth (HP:0000695)2.21037075
69Shallow orbits (HP:0000586)2.20669268
70Premature rupture of membranes (HP:0001788)2.20510036
71Overgrowth (HP:0001548)2.15310395
72Bilateral sensorineural hearing impairment (HP:0008619)2.13839359
73Metaphyseal dysplasia (HP:0100255)2.13617608
74Disproportionate short-trunk short stature (HP:0003521)2.12859985
75Wide anterior fontanel (HP:0000260)2.11779457
76Bowel diverticulosis (HP:0005222)2.11041915
77Joint laxity (HP:0001388)2.10163087
78Arterial tortuosity (HP:0005116)2.08614898
79Dysostosis multiplex (HP:0000943)2.08431548
80Hydroxyprolinuria (HP:0003080)2.08283788
81Abnormality of proline metabolism (HP:0010907)2.08283788
82Elbow flexion contracture (HP:0002987)2.07660096
83Short nail (HP:0001799)2.06953437
84Hyperactive renin-angiotensin system (HP:0000841)2.06136985
85Aortic valve stenosis (HP:0001650)2.05692045
86Neurofibrillary tangles (HP:0002185)2.04998200
87Mild short stature (HP:0003502)2.04622982
88Fetal akinesia sequence (HP:0001989)2.02307919
89Vitreoretinal degeneration (HP:0000655)2.02157154
90Abnormality of dentin (HP:0010299)2.02038283
91Vaginal atresia (HP:0000148)2.01594882
92Abnormal urine output (HP:0012590)2.01413310
93Widely patent fontanelles and sutures (HP:0004492)2.01407567
94Gait imbalance (HP:0002141)1.99815833
95Abnormality of the vertebral endplates (HP:0005106)1.99284875
96Absent hand (HP:0004050)1.98589749
97Aplasia involving bones of the upper limbs (HP:0009823)1.98199265
98Aplasia of the phalanges of the hand (HP:0009802)1.98199265
99Aplasia involving bones of the extremities (HP:0009825)1.98199265
100Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.97798785
101Supranuclear gaze palsy (HP:0000605)1.97617703
102Medial flaring of the eyebrow (HP:0010747)1.97610647
103Striae distensae (HP:0001065)1.97210335
104Abnormality of renal excretion (HP:0011036)1.97189447
105Genital tract atresia (HP:0001827)1.96643243
106Biconcave vertebral bodies (HP:0004586)1.95247836
107Upper limb muscle weakness (HP:0003484)1.94685670
108Congenital primary aphakia (HP:0007707)1.94317292
109Increased neuronal autofluorescent lipopigment (HP:0002074)1.94085531
110Vascular tortuosity (HP:0004948)1.94072237
111Hypoplasia of the odontoid process (HP:0003311)1.93502131
112Increased cerebral lipofuscin (HP:0011813)1.93044529
113Nephrogenic diabetes insipidus (HP:0009806)1.91204414
114Severe Myopia (HP:0011003)1.90880022
115Abnormal delivery (HP:0001787)1.90749743
116Hyperaldosteronism (HP:0000859)1.90339320
117Thoracolumbar scoliosis (HP:0002944)1.90097486
118Delayed closure of the anterior fontanelle (HP:0001476)1.90013318
119Mesomelia (HP:0003027)1.87742695
120Aneurysm (HP:0002617)1.86481423
121Femoral bowing (HP:0002980)1.85996140
122Pheochromocytoma (HP:0002666)1.85789472
123Irregular vertebral endplates (HP:0003301)1.85325543
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84080822
125Short femoral neck (HP:0100864)1.83850939
126Flat cornea (HP:0007720)1.82355904
127Abnormality of the femoral head (HP:0003368)1.80987905
128Aplasia/Hypoplasia of the lens (HP:0008063)1.80234266
129Abnormality of potassium homeostasis (HP:0011042)1.79952404
130Genu varum (HP:0002970)1.79887747
131Increased corneal curvature (HP:0100692)1.79517660
132Keratoconus (HP:0000563)1.79517660
133Distal upper limb amyotrophy (HP:0007149)1.78814551
134Upper limb amyotrophy (HP:0009129)1.78814551
135Hypophosphatemia (HP:0002148)1.78534973
136Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78500606
137Abnormality of femoral epiphyses (HP:0006499)1.78500606
138Type 1 muscle fiber predominance (HP:0003803)1.77220758
139Barrel-shaped chest (HP:0001552)1.76774662
140Cupped ribs (HP:0000887)1.75971305
141Osteoarthritis (HP:0002758)1.75249210
142Joint stiffness (HP:0001387)1.74622126
143Neonatal short-limb short stature (HP:0008921)1.73794187
144Abnormality of the epiphysis of the femoral head (HP:0010574)1.73632477
145Abnormality of glycosphingolipid metabolism (HP:0004343)1.73163816
146Abnormality of glycolipid metabolism (HP:0010969)1.73163816
147Abnormality of liposaccharide metabolism (HP:0010968)1.73163816
148Protuberant abdomen (HP:0001538)1.72259642
149Glucose intolerance (HP:0000833)1.72128534
150Abnormality of chloride homeostasis (HP:0011422)1.71949797
151Adrenal overactivity (HP:0002717)1.71460289
152Mitral regurgitation (HP:0001653)1.71030388
153Ulnar bowing (HP:0003031)1.70576177
154Craniofacial hyperostosis (HP:0004493)1.69708665
155Knee flexion contracture (HP:0006380)1.69376666
156Abnormality of carpal bone ossification (HP:0006257)1.69320537
157Tibial bowing (HP:0002982)1.69036005
158Neuroendocrine neoplasm (HP:0100634)1.68231724
159Decreased circulating renin level (HP:0003351)1.68225126
160Inguinal hernia (HP:0000023)1.67892338
161Hand muscle atrophy (HP:0009130)1.67167790
162Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.67059146
163Abnormality of the odontoid process (HP:0003310)1.66851242
164Tetraparesis (HP:0002273)1.66535536
165Submucous cleft hard palate (HP:0000176)1.66349247
166Bradycardia (HP:0001662)1.66196684
167Mixed hearing impairment (HP:0000410)1.65054864
168Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.64775540
169Abnormal foot bone ossification (HP:0010675)1.64386392
170Slender build (HP:0001533)1.63901673
171Mucopolysacchariduria (HP:0008155)1.63854159
172Urinary glycosaminoglycan excretion (HP:0003541)1.63854159
173Abnormality of mucopolysaccharide metabolism (HP:0011020)1.62753661
174Abnormality of glycosaminoglycan metabolism (HP:0004371)1.62753661
175Arthropathy (HP:0003040)1.60795203
176Protruding ear (HP:0000411)1.60588558
177Osteopenia (HP:0000938)1.60057946
178Nuclear cataract (HP:0100018)1.59720062
179J-shaped sella turcica (HP:0002680)1.59233981
180Nonimmune hydrops fetalis (HP:0001790)1.58774556
181Mildly elevated creatine phosphokinase (HP:0008180)1.57874741
182Xanthomatosis (HP:0000991)1.57826142
183Myocardial infarction (HP:0001658)1.56495690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.79950632
2CASK4.67915964
3PRPF4B3.02896433
4PDGFRA2.74054730
5TNIK2.66315478
6WNK32.63769916
7INSRR2.50260143
8WNK42.50153547
9MAPK152.46942697
10STK392.45230430
11TRPM72.44953405
12LATS12.42845218
13IRAK12.35783769
14OXSR12.27934250
15TGFBR22.05301947
16STK382.00866474
17EPHA32.00029712
18MAPKAPK31.93595521
19BLK1.84568969
20NTRK31.84554045
21NEK91.83913918
22IRAK21.73441531
23FLT31.72506481
24IRAK31.66420710
25MAP3K141.62776262
26TTN1.55608857
27NTRK11.53880565
28PBK1.53333459
29EEF2K1.53263921
30MOS1.50069422
31EPHA21.49744535
32BMPR1B1.49723572
33RIPK11.48360150
34PAK21.45036358
35IRAK41.42126456
36BMPR21.41816527
37DDR21.38935497
38LATS21.38569089
39PKN11.33584013
40STK38L1.33067816
41PAK31.31498845
42NEK61.31465656
43MET1.30061600
44GRK71.26757672
45STK31.26599060
46BCR1.25743379
47MAP3K131.24874723
48SGK2231.23327656
49SGK4941.23327656
50PRKCE1.23250081
51TIE11.23149803
52EPHB21.21003168
53PKN21.20234166
54MST1R1.19039130
55CDK121.12745657
56TRIB31.12146614
57PTK2B1.11086492
58CDC42BPA1.10933412
59TNK21.10670698
60GRK11.07525273
61PRKG21.06255345
62CAMK1G1.05078022
63EPHB11.03671369
64MAPK131.03448881
65PHKG21.03044138
66PHKG11.03044138
67PRKD31.01816657
68WNK11.01486663
69MUSK1.00981267
70PLK21.00878163
71MAP3K31.00552269
72CAMK2A0.98308326
73ERN10.96044652
74MST40.93015874
75FER0.91525796
76MAP3K70.89240591
77NME10.87555249
78PAK60.86378935
79FES0.86089419
80CAMK2D0.84555692
81CAMKK20.83685498
82LIMK10.83545253
83RPS6KA20.82289661
84ROCK10.81830219
85EIF2AK20.81602633
86MTOR0.79384459
87ACVR1B0.76635028
88PTK20.76258332
89CAMK2B0.74679936
90CAMK1D0.74181930
91ROCK20.71184479
92UHMK10.70937334
93ABL20.70168671
94PIM20.69314519
95ADRBK20.69310868
96DYRK20.68023743
97ARAF0.67719948
98MAP2K10.66555706
99SIK10.64798111
100CAMK2G0.64554146
101PRKCG0.63014161
102GSK3A0.62685963
103MARK10.62337421
104NLK0.61489740
105STK240.60737905
106PRKCH0.59904253
107MAPKAPK50.59557431
108HIPK20.59219422
109RIPK40.59167372
110KIT0.57485550
111CDK50.55708447
112ADRBK10.53454104
113PIK3CA0.53005227
114ERBB40.52783190
115PAK40.52745662
116SGK20.52584891
117JAK10.51143208
118YES10.50326105
119SGK10.50293872
120MELK0.49395380
121PRKAA20.48234430
122MAP3K60.48045744
123NUAK10.47941517
124TGFBR10.46121495
125FGR0.45821094
126PRKD20.45461736
127TESK10.45056950
128PASK0.44865715
129PRKACA0.42021412
130PRKCQ0.41924031
131PDPK10.41588841
132NTRK20.41410131
133PIK3CG0.40487806
134FGFR30.40391221
135ERBB30.39550740
136PDGFRB0.39188896
137CDK30.38833386
138MYLK0.37986608
139AKT30.37682207
140STK160.36896320
141CDK60.35950371
142PRKG10.35811162
143PRKCD0.35165882
144CDK80.34386293
145PRKCA0.34376628
146INSR0.34282480
147MAP4K20.33271276
148ABL10.32909155
149MAP3K20.32749928
150IGF1R0.32741372
151BMX0.32654861
152RET0.31669625
153MARK30.30701800
154LMTK20.30680078
155MAP3K90.30496532
156SRC0.29676782

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.33393953
2Protein export_Homo sapiens_hsa030602.27463801
3Collecting duct acid secretion_Homo sapiens_hsa049662.26957887
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.02832920
5Sphingolipid metabolism_Homo sapiens_hsa006001.99144823
6Vibrio cholerae infection_Homo sapiens_hsa051101.98690236
7Insulin secretion_Homo sapiens_hsa049111.93889243
8Steroid biosynthesis_Homo sapiens_hsa001001.88539676
9Other glycan degradation_Homo sapiens_hsa005111.86468062
10Rheumatoid arthritis_Homo sapiens_hsa053231.76377192
11Synaptic vesicle cycle_Homo sapiens_hsa047211.73982202
12Lysosome_Homo sapiens_hsa041421.64787040
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60295928
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59475158
15Selenocompound metabolism_Homo sapiens_hsa004501.58884975
16Morphine addiction_Homo sapiens_hsa050321.54500626
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51609063
18N-Glycan biosynthesis_Homo sapiens_hsa005101.51437685
19Nicotine addiction_Homo sapiens_hsa050331.46400921
20Type I diabetes mellitus_Homo sapiens_hsa049401.42022341
21Phagosome_Homo sapiens_hsa041451.39744204
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.37028772
23Amoebiasis_Homo sapiens_hsa051461.35242786
24ABC transporters_Homo sapiens_hsa020101.34627823
25Complement and coagulation cascades_Homo sapiens_hsa046101.34046931
26Serotonergic synapse_Homo sapiens_hsa047261.30958452
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29492703
28Sulfur metabolism_Homo sapiens_hsa009201.26500350
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.26118714
30Proteoglycans in cancer_Homo sapiens_hsa052051.24732951
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24308342
32Protein digestion and absorption_Homo sapiens_hsa049741.21940951
33Taste transduction_Homo sapiens_hsa047421.20449309
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18749812
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16475853
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16416253
37GABAergic synapse_Homo sapiens_hsa047271.16126032
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15871427
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14582593
40Circadian entrainment_Homo sapiens_hsa047131.13994956
41Axon guidance_Homo sapiens_hsa043601.13801689
42Mineral absorption_Homo sapiens_hsa049781.13636419
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13053435
44Ether lipid metabolism_Homo sapiens_hsa005651.12623259
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12441843
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12265347
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.09785398
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09262665
49ECM-receptor interaction_Homo sapiens_hsa045121.08499133
50Glutamatergic synapse_Homo sapiens_hsa047241.07509010
51Cocaine addiction_Homo sapiens_hsa050301.06709025
52Cholinergic synapse_Homo sapiens_hsa047251.04748025
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01053614
54Oxidative phosphorylation_Homo sapiens_hsa001900.99976187
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99663805
56Small cell lung cancer_Homo sapiens_hsa052220.97110907
57Adherens junction_Homo sapiens_hsa045200.95062828
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.94183086
59Ovarian steroidogenesis_Homo sapiens_hsa049130.94045931
60Olfactory transduction_Homo sapiens_hsa047400.92483570
61TGF-beta signaling pathway_Homo sapiens_hsa043500.90643843
62Histidine metabolism_Homo sapiens_hsa003400.90603026
63Dilated cardiomyopathy_Homo sapiens_hsa054140.89966497
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89808046
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89162470
66Salivary secretion_Homo sapiens_hsa049700.85229328
67Amphetamine addiction_Homo sapiens_hsa050310.83877813
68Gastric acid secretion_Homo sapiens_hsa049710.83785371
69Long-term depression_Homo sapiens_hsa047300.83460319
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81210823
71Dorso-ventral axis formation_Homo sapiens_hsa043200.80692010
72Phototransduction_Homo sapiens_hsa047440.80676989
73Malaria_Homo sapiens_hsa051440.79944634
74Platelet activation_Homo sapiens_hsa046110.79746941
75Graft-versus-host disease_Homo sapiens_hsa053320.79294598
76Type II diabetes mellitus_Homo sapiens_hsa049300.79257385
77Allograft rejection_Homo sapiens_hsa053300.79140951
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79088327
79Bladder cancer_Homo sapiens_hsa052190.78491615
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77863741
81Glycerolipid metabolism_Homo sapiens_hsa005610.77425280
82Tryptophan metabolism_Homo sapiens_hsa003800.77186197
83Calcium signaling pathway_Homo sapiens_hsa040200.76558833
84cAMP signaling pathway_Homo sapiens_hsa040240.74214077
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74126236
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69623567
87Pancreatic secretion_Homo sapiens_hsa049720.69358011
88Ras signaling pathway_Homo sapiens_hsa040140.67607030
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.67240909
90Arachidonic acid metabolism_Homo sapiens_hsa005900.67087644
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.66681933
92Chemical carcinogenesis_Homo sapiens_hsa052040.66604651
93Dopaminergic synapse_Homo sapiens_hsa047280.66305432
94Glutathione metabolism_Homo sapiens_hsa004800.66094102
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65939903
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65082311
97Butanoate metabolism_Homo sapiens_hsa006500.64424883
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64370818
99Hedgehog signaling pathway_Homo sapiens_hsa043400.64298616
100Melanoma_Homo sapiens_hsa052180.64017956
101Circadian rhythm_Homo sapiens_hsa047100.62251525
102Thyroid hormone synthesis_Homo sapiens_hsa049180.61461936
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61436285
104PPAR signaling pathway_Homo sapiens_hsa033200.60063202
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59953532
106Choline metabolism in cancer_Homo sapiens_hsa052310.59941951
107Fatty acid elongation_Homo sapiens_hsa000620.59508447
108Arginine and proline metabolism_Homo sapiens_hsa003300.59253323
109ErbB signaling pathway_Homo sapiens_hsa040120.59001443
110Hippo signaling pathway_Homo sapiens_hsa043900.58980049
111Autoimmune thyroid disease_Homo sapiens_hsa053200.58746655
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58308044
113Renin-angiotensin system_Homo sapiens_hsa046140.57820397
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57296758
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56859856
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.56205776
117Cardiac muscle contraction_Homo sapiens_hsa042600.55682938
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55640631
119MicroRNAs in cancer_Homo sapiens_hsa052060.55520944
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54774712
121Starch and sucrose metabolism_Homo sapiens_hsa005000.54108297
122TNF signaling pathway_Homo sapiens_hsa046680.53611060
123Fatty acid biosynthesis_Homo sapiens_hsa000610.53360436
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53138609
125Fatty acid degradation_Homo sapiens_hsa000710.53027052
126Renin secretion_Homo sapiens_hsa049240.52645926
127Fatty acid metabolism_Homo sapiens_hsa012120.52376716
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52198801
129Focal adhesion_Homo sapiens_hsa045100.51978453
130Inositol phosphate metabolism_Homo sapiens_hsa005620.50839856
131Alzheimers disease_Homo sapiens_hsa050100.50509174
132Retinol metabolism_Homo sapiens_hsa008300.50233004
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49050014
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48801032
135Chronic myeloid leukemia_Homo sapiens_hsa052200.48527367
136Gap junction_Homo sapiens_hsa045400.48032315
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.47743962
138Tight junction_Homo sapiens_hsa045300.47554763
139Pathways in cancer_Homo sapiens_hsa052000.47258515
140Renal cell carcinoma_Homo sapiens_hsa052110.47076557
141Chemokine signaling pathway_Homo sapiens_hsa040620.46392367
142Insulin resistance_Homo sapiens_hsa049310.46238080
143Galactose metabolism_Homo sapiens_hsa000520.46162653
144Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45731063
145Lysine degradation_Homo sapiens_hsa003100.45711111
146Regulation of autophagy_Homo sapiens_hsa041400.45561581
147Prion diseases_Homo sapiens_hsa050200.44520656
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44455001
149GnRH signaling pathway_Homo sapiens_hsa049120.44163858
150Melanogenesis_Homo sapiens_hsa049160.43962579
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.40411339
152Linoleic acid metabolism_Homo sapiens_hsa005910.39233827
153Bile secretion_Homo sapiens_hsa049760.38676045
154mTOR signaling pathway_Homo sapiens_hsa041500.38293375
155Fat digestion and absorption_Homo sapiens_hsa049750.38233870
156Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36947484

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