TMCC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)9.77343282
2gas transport (GO:0015669)8.68868729
3porphyrin-containing compound biosynthetic process (GO:0006779)7.83990073
4tetrapyrrole biosynthetic process (GO:0033014)6.99769011
5response to methylmercury (GO:0051597)6.95333202
6heme biosynthetic process (GO:0006783)6.74014562
7porphyrin-containing compound metabolic process (GO:0006778)6.08329864
8hemoglobin metabolic process (GO:0020027)5.69510649
9synaptic vesicle maturation (GO:0016188)5.63052273
10response to insecticide (GO:0017085)5.16196053
11heme metabolic process (GO:0042168)5.08542684
12erythrocyte maturation (GO:0043249)4.96604613
13locomotory exploration behavior (GO:0035641)4.93820702
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.74861243
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58304276
16glycine transport (GO:0015816)4.49892108
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.42920164
18response to lead ion (GO:0010288)4.31710292
19erythrocyte development (GO:0048821)4.30398435
20actin filament capping (GO:0051693)4.06305137
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.03850195
22vocalization behavior (GO:0071625)4.03456229
23regulation of synaptic vesicle exocytosis (GO:2000300)4.00471817
24synaptic vesicle exocytosis (GO:0016079)3.92158835
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.89265017
26glutamate secretion (GO:0014047)3.87934371
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.86365596
28negative regulation of dendrite morphogenesis (GO:0050774)3.83137363
29positive regulation of Rap GTPase activity (GO:0032854)3.82431263
30layer formation in cerebral cortex (GO:0021819)3.81548572
31tetrapyrrole metabolic process (GO:0033013)3.72609932
32regulation of neuronal synaptic plasticity (GO:0048168)3.67685244
33regulation of glutamate receptor signaling pathway (GO:1900449)3.64954148
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.60502717
35positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.59810354
36neuronal action potential propagation (GO:0019227)3.59426385
37L-amino acid import (GO:0043092)3.58073128
38positive regulation of fibroblast migration (GO:0010763)3.55228912
39bicarbonate transport (GO:0015701)3.54921385
40protein localization to synapse (GO:0035418)3.54760708
41exploration behavior (GO:0035640)3.54637916
42central nervous system myelination (GO:0022010)3.52624920
43axon ensheathment in central nervous system (GO:0032291)3.52624920
44regulation of synaptic vesicle transport (GO:1902803)3.51537735
45sodium ion export (GO:0071436)3.51515020
463-UTR-mediated mRNA stabilization (GO:0070935)3.49802681
47regulation of synapse structural plasticity (GO:0051823)3.48754338
48neuron cell-cell adhesion (GO:0007158)3.43359680
49dendritic spine morphogenesis (GO:0060997)3.42109412
50regulation of Rap GTPase activity (GO:0032317)3.38200725
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.36518504
52nerve growth factor signaling pathway (GO:0038180)3.35958341
53regulation of response to osmotic stress (GO:0047484)3.35807610
54negative regulation of actin filament depolymerization (GO:0030835)3.34832430
55myeloid cell development (GO:0061515)3.33893339
56neuromuscular process controlling balance (GO:0050885)3.31698417
57gamma-aminobutyric acid transport (GO:0015812)3.31105323
58import into cell (GO:0098657)3.28285434
59neurotransmitter secretion (GO:0007269)3.27563688
60positive regulation of neurotransmitter secretion (GO:0001956)3.27528442
61cellular potassium ion homeostasis (GO:0030007)3.25667062
62glutamate receptor signaling pathway (GO:0007215)3.23823209
63activation of protein kinase A activity (GO:0034199)3.23462065
64mitochondrion degradation (GO:0000422)3.23237504
65synaptic vesicle endocytosis (GO:0048488)3.21848972
66cerebellar Purkinje cell differentiation (GO:0021702)3.20890558
67regulation of ARF protein signal transduction (GO:0032012)3.18375468
68phosphatidylethanolamine biosynthetic process (GO:0006646)3.17889930
69erythrocyte differentiation (GO:0030218)3.17152939
70long-term memory (GO:0007616)3.16911940
71regulation of cAMP-dependent protein kinase activity (GO:2000479)3.15828707
72cell differentiation in hindbrain (GO:0021533)3.14517853
73modulation by virus of host process (GO:0019054)3.09820766
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.08737426
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06767982
76regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.06350769
77negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.06244598
78phosphatidylethanolamine metabolic process (GO:0046337)3.04234876
79synaptic transmission, glutamatergic (GO:0035249)3.04040378
80neurotransmitter-gated ion channel clustering (GO:0072578)3.03823050
81adult walking behavior (GO:0007628)3.03414639
82cell migration in hindbrain (GO:0021535)3.03328243
83cellular response to virus (GO:0098586)3.01206456
84positive regulation of neurotransmitter transport (GO:0051590)2.98405482
85megakaryocyte development (GO:0035855)2.95025430
86neuromuscular process controlling posture (GO:0050884)2.94576790
87transmission of nerve impulse (GO:0019226)2.94241482
88negative regulation of erythrocyte differentiation (GO:0045647)2.91656608
89regulation of dendritic spine morphogenesis (GO:0061001)2.90533331
90dendrite morphogenesis (GO:0048813)2.90506918
91positive regulation of membrane potential (GO:0045838)2.89261287
92neuron-neuron synaptic transmission (GO:0007270)2.89215056
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88330829
94autophagic vacuole assembly (GO:0000045)2.87599660
95regulation of excitatory postsynaptic membrane potential (GO:0060079)2.87414058
96neuronal ion channel clustering (GO:0045161)2.85709192
97neurotransmitter transport (GO:0006836)2.82180671
98clathrin coat assembly (GO:0048268)2.80496130
99neuron recognition (GO:0008038)2.80474352
100amino acid import (GO:0043090)2.80211917
101pigment biosynthetic process (GO:0046148)2.79016773
102regulation of ARF GTPase activity (GO:0032312)2.78517926
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76563119
104negative regulation of execution phase of apoptosis (GO:1900118)2.76075134
105positive regulation of synapse maturation (GO:0090129)2.75817296
106negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.75305884
107one-carbon compound transport (GO:0019755)2.73606687
108cerebellar granule cell differentiation (GO:0021707)2.72484734
109modulation by symbiont of host cellular process (GO:0044068)2.72343730
110regulation of platelet aggregation (GO:0090330)2.71441874
111regulation of synaptic plasticity (GO:0048167)2.69801513
112postsynaptic membrane organization (GO:0001941)2.68193337
113potassium ion homeostasis (GO:0055075)2.67945204
114auditory behavior (GO:0031223)2.66606762
115protein targeting to plasma membrane (GO:0072661)2.66549697
116regulation of postsynaptic membrane potential (GO:0060078)2.66504371
117ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.65998132
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.65120052
119negative regulation of glial cell proliferation (GO:0060253)2.65062226
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.65052673
121negative regulation of actin filament polymerization (GO:0030837)2.65026569
122potassium ion import (GO:0010107)2.64632747
123cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.64268159
124cerebellar Purkinje cell layer development (GO:0021680)2.64014852
125negative regulation of neurotransmitter transport (GO:0051589)2.64004090
126regulation of female receptivity (GO:0045924)2.62680442
127regulation of neurotransmitter secretion (GO:0046928)2.62660491
128calcium-mediated signaling using intracellular calcium source (GO:0035584)2.62444441
129granulocyte differentiation (GO:0030851)2.60964474
130proline transport (GO:0015824)2.60729615
131cellular response to nerve growth factor stimulus (GO:1990090)2.60648723
132response to nerve growth factor (GO:1990089)2.60648723
133prepulse inhibition (GO:0060134)2.60195309
134phosphatidylcholine biosynthetic process (GO:0006656)2.58537354
135negative regulation of protein polymerization (GO:0032272)2.57798028
136protoporphyrinogen IX metabolic process (GO:0046501)12.1595866
137protoporphyrinogen IX biosynthetic process (GO:0006782)10.7306873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.35124896
2* GATA1_19941826_ChIP-Seq_K562_Human4.29842998
3GATA1_22025678_ChIP-Seq_K562_Human3.52028865
4* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.28148938
5* GATA1_19941827_ChIP-Seq_MEL_Mouse2.94499287
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87601222
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.82923611
8* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.80260511
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60132632
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56813212
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45536800
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36215624
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.34967760
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.34003965
15REST_21632747_ChIP-Seq_MESCs_Mouse2.32141840
16* GATA2_19941826_ChIP-Seq_K562_Human2.29591848
17DROSHA_22980978_ChIP-Seq_HELA_Human2.27679374
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27034062
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26114106
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.22083304
21* KDM2B_26808549_Chip-Seq_K562_Human2.14800566
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12029637
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12029637
24TCF7_22412390_ChIP-Seq_EML_Mouse2.11212352
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08150930
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.04102460
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03911453
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03179222
29GBX2_23144817_ChIP-Seq_PC3_Human2.00353743
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.98480735
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88537190
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87169789
33* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.84829673
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.84331363
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81501883
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.77112262
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.75700097
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.74765047
39* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.74314427
40AR_21572438_ChIP-Seq_LNCaP_Human1.69885688
41SCL_19346495_ChIP-Seq_HPC-7_Human1.64806140
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62926258
43GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62058624
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59494101
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59273483
46ZNF263_19887448_ChIP-Seq_K562_Human1.58862569
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51672274
48* KDM2B_26808549_Chip-Seq_DND41_Human1.46981849
49GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44973858
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44344994
51* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36139577
52* NCOR1_26117541_ChIP-Seq_K562_Human1.28725468
53WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28676053
54VDR_21846776_ChIP-Seq_THP-1_Human1.26731402
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26344868
56P68_20966046_ChIP-Seq_HELA_Human1.21091528
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20307841
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18933602
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18458678
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.18225434
61* KDM2B_26808549_Chip-Seq_JURKAT_Human1.16594946
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14786190
63* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13993745
64GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.13562838
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13054691
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12313260
67* SA1_27219007_Chip-Seq_ERYTHROID_Human1.10752179
68* CTCF_27219007_Chip-Seq_Bcells_Human1.10469078
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.07547344
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06329813
71DPY_21335234_ChIP-Seq_ESCs_Mouse1.03795621
72* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03615725
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02620350
74* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02214309
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.01973501
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01862172
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.01752817
78AR_19668381_ChIP-Seq_PC3_Human1.00618053
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00402920
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00174702
81NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99702749
82TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99220320
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99196641
84LXR_22292898_ChIP-Seq_THP-1_Human0.98763917
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98689144
86GATA1_26923725_Chip-Seq_HPCs_Mouse0.97775627
87FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97651397
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97637294
89GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97471166
90CREB1_26743006_Chip-Seq_LNCaP_Human0.96526070
91MYC_22102868_ChIP-Seq_BL_Human0.96123815
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95475724
93OCT4_19829295_ChIP-Seq_ESCs_Human0.95417559
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95371176
95P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94742495
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94083651
97* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93992443
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93867512
99* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93825621
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93745920
101TP53_16413492_ChIP-PET_HCT116_Human0.93731897
102BCOR_27268052_Chip-Seq_Bcells_Human0.93712944
103* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93563389
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92323281
105* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92075333
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91754639
107ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91741519
108* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90919987
109YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90906502
110SPI1_23127762_ChIP-Seq_K562_Human0.90538202
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90529814
112* TET1_21490601_ChIP-Seq_MESCs_Mouse0.90246597
113* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89315619
114TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89059408
115BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88968461
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88684179
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88458965
118RING1B_27294783_Chip-Seq_NPCs_Mouse0.88043890
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87434038
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87397289
121CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86531298
122* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86077154
123FOXM1_23109430_ChIP-Seq_U2OS_Human0.85292629
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.84239300
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.82514533
126STAT3_23295773_ChIP-Seq_U87_Human0.80080787
127KLF4_19829295_ChIP-Seq_ESCs_Human0.79813809
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79426378
129SMAD4_21799915_ChIP-Seq_A2780_Human0.79213393
130SMC4_20622854_ChIP-Seq_HELA_Human0.78756232
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.78279812
132SMAD3_21741376_ChIP-Seq_EPCs_Human0.78127244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo7.69130826
2MP0004859_abnormal_synaptic_plasticity6.12663500
3MP0004147_increased_porphyrin_level6.11386537
4MP0003880_abnormal_central_pattern3.70579978
5MP0003635_abnormal_synaptic_transmissio3.41682491
6MP0004270_analgesia3.18848688
7MP0009745_abnormal_behavioral_response2.71537416
8MP0002064_seizures2.66793350
9MP0005423_abnormal_somatic_nervous2.65920805
10MP0002063_abnormal_learning/memory/cond2.62780232
11MP0009046_muscle_twitch2.48957324
12MP0003303_peritoneal_inflammation2.45827229
13MP0002734_abnormal_mechanical_nocicepti2.38122627
14MP0005397_hematopoietic_system_phenotyp2.36960840
15MP0001545_abnormal_hematopoietic_system2.36960840
16MP0001968_abnormal_touch/_nociception2.33860527
17MP0002272_abnormal_nervous_system2.20260523
18MP0003329_amyloid_beta_deposits2.13951952
19MP0002822_catalepsy2.12561356
20MP0001486_abnormal_startle_reflex2.05704674
21MP0005083_abnormal_biliary_tract2.04852770
22MP0002572_abnormal_emotion/affect_behav1.95913465
23MP0003172_abnormal_lysosome_physiology1.93232968
24MP0008569_lethality_at_weaning1.85923858
25MP0000920_abnormal_myelination1.81821573
26MP0002736_abnormal_nociception_after1.80975216
27MP0009278_abnormal_bone_marrow1.80510961
28MP0004811_abnormal_neuron_physiology1.78630704
29MP0002733_abnormal_thermal_nociception1.75514595
30MP0001440_abnormal_grooming_behavior1.70998855
31MP0002735_abnormal_chemical_nociception1.70815065
32MP0001970_abnormal_pain_threshold1.70290149
33MP0001529_abnormal_vocalization1.68082474
34MP0004885_abnormal_endolymph1.60726980
35MP0002067_abnormal_sensory_capabilities1.57453801
36MP0000955_abnormal_spinal_cord1.49946371
37MP0008995_early_reproductive_senescence1.47443830
38MP0005386_behavior/neurological_phenoty1.42901603
39MP0004924_abnormal_behavior1.42901603
40MP0000778_abnormal_nervous_system1.41716565
41MP0003787_abnormal_imprinting1.40072332
42MP0008872_abnormal_physiological_respon1.39697663
43MP0005464_abnormal_platelet_physiology1.39495509
44MP0003633_abnormal_nervous_system1.36668027
45MP0002066_abnormal_motor_capabilities/c1.33428637
46MP0002882_abnormal_neuron_morphology1.32362175
47MP0003690_abnormal_glial_cell1.32174842
48MP0003631_nervous_system_phenotype1.31309032
49MP0004142_abnormal_muscle_tone1.30749149
50MP0001501_abnormal_sleep_pattern1.30164528
51MP0000015_abnormal_ear_pigmentation1.29744557
52MP0002909_abnormal_adrenal_gland1.29234966
53MP0002229_neurodegeneration1.24556396
54MP0002184_abnormal_innervation1.19380498
55MP0003123_paternal_imprinting1.17727482
56MP0002557_abnormal_social/conspecific_i1.16236391
57MP0003634_abnormal_glial_cell1.15253646
58MP0009780_abnormal_chondrocyte_physiolo1.13205872
59MP0001905_abnormal_dopamine_level1.12060965
60MP0003632_abnormal_nervous_system1.11319410
61MP0004858_abnormal_nervous_system1.09654317
62MP0003075_altered_response_to1.09609790
63MP0003879_abnormal_hair_cell1.09406294
64MP0008775_abnormal_heart_ventricle1.07737724
65MP0004085_abnormal_heartbeat1.06484968
66MP0002152_abnormal_brain_morphology1.01422263
67MP0004145_abnormal_muscle_electrophysio1.01355017
68MP0002095_abnormal_skin_pigmentation0.94141496
69MP0000604_amyloidosis0.93199633
70MP0000747_muscle_weakness0.90372803
71MP0008770_decreased_survivor_rate0.87912146
72MP0005646_abnormal_pituitary_gland0.87749930
73MP0005636_abnormal_mineral_homeostasis0.87424188
74MP0001188_hyperpigmentation0.86763570
75MP0000749_muscle_degeneration0.85821601
76MP0003045_fibrosis0.85650084
77MP0005645_abnormal_hypothalamus_physiol0.84956504
78MP0008260_abnormal_autophagy0.84756760
79MP0004742_abnormal_vestibular_system0.83400293
80MP0005551_abnormal_eye_electrophysiolog0.83399468
81MP0001986_abnormal_taste_sensitivity0.80804899
82MP0004215_abnormal_myocardial_fiber0.80596422
83MP0005174_abnormal_tail_pigmentation0.80559687
84MP0005451_abnormal_body_composition0.78917598
85MP0001299_abnormal_eye_distance/0.78328816
86MP0000751_myopathy0.76528833
87MP0003122_maternal_imprinting0.76348301
88MP0005167_abnormal_blood-brain_barrier0.74437158
89MP0004808_abnormal_hematopoietic_stem0.74154503
90MP0002090_abnormal_vision0.74094292
91MP0004043_abnormal_pH_regulation0.71712143
92MP0005377_hearing/vestibular/ear_phenot0.70242139
93MP0003878_abnormal_ear_physiology0.70242139
94MP0008874_decreased_physiological_sensi0.68835234
95MP0005623_abnormal_meninges_morphology0.67415710
96MP0005394_taste/olfaction_phenotype0.66869330
97MP0005499_abnormal_olfactory_system0.66869330
98MP0001502_abnormal_circadian_rhythm0.66732940
99MP0005076_abnormal_cell_differentiation0.64242868
100MP0003137_abnormal_impulse_conducting0.63945474
101MP0005535_abnormal_body_temperature0.62879306
102MP0002069_abnormal_eating/drinking_beha0.62571203
103MP0002752_abnormal_somatic_nervous0.60857060
104MP0005171_absent_coat_pigmentation0.60446006
105MP0005409_darkened_coat_color0.59348093
106MP0002653_abnormal_ependyma_morphology0.58739716
107MP0000003_abnormal_adipose_tissue0.58419786
108MP0004484_altered_response_of0.58295507
109MP0003283_abnormal_digestive_organ0.58090207
110MP0006276_abnormal_autonomic_nervous0.57884862
111MP0001177_atelectasis0.56725839
112MP0003191_abnormal_cellular_cholesterol0.56156952
113MP0010769_abnormal_survival0.55536308
114MP0004510_myositis0.55419160
115MP0005620_abnormal_muscle_contractility0.55358463
116MP0004130_abnormal_muscle_cell0.54841953
117MP0010768_mortality/aging0.52166304
118MP0002837_dystrophic_cardiac_calcinosis0.51596437
119MP0001984_abnormal_olfaction0.50960872
120MP0002972_abnormal_cardiac_muscle0.50848742
121MP0005075_abnormal_melanosome_morpholog0.50373293
122MP0001963_abnormal_hearing_physiology0.50335756
123MP0008961_abnormal_basal_metabolism0.50203447
124MP0002083_premature_death0.49171027
125MP0008004_abnormal_stomach_pH0.47895535
126MP0009765_abnormal_xenobiotic_induced0.46113959
127MP0002638_abnormal_pupillary_reflex0.45455483
128MP0005310_abnormal_salivary_gland0.45137182
129MP0002398_abnormal_bone_marrow0.44592597
130MP0009764_decreased_sensitivity_to0.43102296
131MP0003186_abnormal_redox_activity0.42070197
132MP0002332_abnormal_exercise_endurance0.41771821

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)9.62584111
2Abnormality of the heme biosynthetic pathway (HP:0010472)8.90772456
3Hypochromic microcytic anemia (HP:0004840)7.32859408
4Acanthocytosis (HP:0001927)6.69216864
5Reticulocytosis (HP:0001923)6.31745695
6Abnormal hemoglobin (HP:0011902)5.49777211
7Insomnia (HP:0100785)5.35023328
8Cholelithiasis (HP:0001081)5.34121723
9Myokymia (HP:0002411)4.99306235
10Abnormal gallbladder morphology (HP:0012437)4.87041052
11Diaphragmatic weakness (HP:0009113)4.73426695
12Paralysis (HP:0003470)4.55739178
13Focal motor seizures (HP:0011153)3.98383018
14Focal seizures (HP:0007359)3.90182597
15Osteomalacia (HP:0002749)3.74782173
16Visual hallucinations (HP:0002367)3.71200879
17Depression (HP:0000716)3.62016327
18Supranuclear gaze palsy (HP:0000605)3.52080242
19Hyperbilirubinemia (HP:0002904)3.41687367
20Abnormal gallbladder physiology (HP:0012438)3.40205613
21Cholecystitis (HP:0001082)3.40205613
22Abnormality of the gallbladder (HP:0005264)3.26999559
23Abnormality of reticulocytes (HP:0004312)3.24042546
24Generalized tonic-clonic seizures (HP:0002069)3.21450950
25Ankle clonus (HP:0011448)3.19592803
26Epileptic encephalopathy (HP:0200134)3.15972944
27Anxiety (HP:0000739)3.15121921
28Postural instability (HP:0002172)3.12151350
29Action tremor (HP:0002345)3.04921711
30Cerebral inclusion bodies (HP:0100314)3.00975799
31Neurofibrillary tangles (HP:0002185)2.92978614
32Intention tremor (HP:0002080)2.83939969
33Hypochromic anemia (HP:0001931)2.82417030
34Microcytic anemia (HP:0001935)2.73754778
35Abnormality of the fingertips (HP:0001211)2.70942387
36Prolonged bleeding time (HP:0003010)2.70498026
37Hemiparesis (HP:0001269)2.70379397
38Dysmetria (HP:0001310)2.68007679
39Truncal ataxia (HP:0002078)2.67346307
40Delusions (HP:0000746)2.67281948
41Febrile seizures (HP:0002373)2.66836658
42Abnormality of the corticospinal tract (HP:0002492)2.61158372
43Dysdiadochokinesis (HP:0002075)2.60562031
44Poor eye contact (HP:0000817)2.59739162
45Abnormality of binocular vision (HP:0011514)2.59072568
46Diplopia (HP:0000651)2.59072568
47Lower limb amyotrophy (HP:0007210)2.57238917
48Toxemia of pregnancy (HP:0100603)2.53829354
49Spastic gait (HP:0002064)2.53704769
50Termporal pattern (HP:0011008)2.52708681
51Insidious onset (HP:0003587)2.52708681
52Atonic seizures (HP:0010819)2.50245475
53Papilledema (HP:0001085)2.50144054
54Urinary bladder sphincter dysfunction (HP:0002839)2.48026457
55Impaired social interactions (HP:0000735)2.47497415
56Abnormal social behavior (HP:0012433)2.47497415
57Urinary urgency (HP:0000012)2.45526014
58Confusion (HP:0001289)2.44695348
59Impaired vibration sensation in the lower limbs (HP:0002166)2.43880415
60Progressive cerebellar ataxia (HP:0002073)2.39581961
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.38190283
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38190283
63Dialeptic seizures (HP:0011146)2.33505479
64Polycythemia (HP:0001901)2.33170439
65Global brain atrophy (HP:0002283)2.28409623
66Cutaneous photosensitivity (HP:0000992)2.26961306
67Absence seizures (HP:0002121)2.26814706
68Decreased motor nerve conduction velocity (HP:0003431)2.26434327
69Progressive inability to walk (HP:0002505)2.21728368
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21160074
71Ileus (HP:0002595)2.19964210
72Ocular albinism (HP:0001107)2.17241793
73Lower limb muscle weakness (HP:0007340)2.16207653
74Slow saccadic eye movements (HP:0000514)2.14912236
75Megalencephaly (HP:0001355)2.14889221
76Peripheral hypomyelination (HP:0007182)2.11334787
77Bradykinesia (HP:0002067)2.10567678
78Abnormality of iron homeostasis (HP:0011031)2.06481587
79Scanning speech (HP:0002168)2.05920522
80Psychosis (HP:0000709)2.02672934
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02467377
82Iris hypopigmentation (HP:0007730)2.02119862
83Broad-based gait (HP:0002136)2.01831988
84Sleep apnea (HP:0010535)2.01250415
85Status epilepticus (HP:0002133)2.01207228
86Pustule (HP:0200039)2.00481444
87Abnormality of sodium homeostasis (HP:0010931)2.00073555
88Impaired smooth pursuit (HP:0007772)1.98909881
89Onion bulb formation (HP:0003383)1.94507333
90Macroorchidism (HP:0000053)1.93510177
91Clonus (HP:0002169)1.93149371
92Gaze-evoked nystagmus (HP:0000640)1.92750559
93Cerebral hypomyelination (HP:0006808)1.92215993
94Absent speech (HP:0001344)1.91344315
95Generalized hyperpigmentation (HP:0007440)1.90845871
96Mutism (HP:0002300)1.90483159
97Annular pancreas (HP:0001734)1.90173241
98Childhood onset (HP:0011463)1.90128604
99Cortical visual impairment (HP:0100704)1.89060355
100Torticollis (HP:0000473)1.87761002
101Hypercortisolism (HP:0001578)1.87153287
102Abnormality of the lower motor neuron (HP:0002366)1.82976602
103Limb dystonia (HP:0002451)1.80696022
104Hyponatremia (HP:0002902)1.76242104
105Thickened helices (HP:0000391)1.76032103
106Stereotypic behavior (HP:0000733)1.75470235
107Severe visual impairment (HP:0001141)1.75386884
108Gastrointestinal infarctions (HP:0005244)1.74923628
109Incomplete penetrance (HP:0003829)1.74328502
110Rigidity (HP:0002063)1.74010984
111Clumsiness (HP:0002312)1.73303249
112Autoamputation (HP:0001218)1.72815966
113Progressive microcephaly (HP:0000253)1.71390691
114Resting tremor (HP:0002322)1.70615257
115Abnormality of saccadic eye movements (HP:0000570)1.69988371
116Dysmetric saccades (HP:0000641)1.69932658
117Muscle fiber splitting (HP:0003555)1.69091219
118Abnormality of ocular smooth pursuit (HP:0000617)1.69009103
119Choreoathetosis (HP:0001266)1.68946990
120Germ cell neoplasia (HP:0100728)1.67885519
121Focal dystonia (HP:0004373)1.67188397
122Urinary incontinence (HP:0000020)1.66572486
123Paresthesia (HP:0003401)1.65936443
124Generalized myoclonic seizures (HP:0002123)1.65780169
125Rapidly progressive (HP:0003678)1.65684878
126Osteomyelitis (HP:0002754)1.65655406
127Abnormal eating behavior (HP:0100738)1.65476915
128Abnormality of transition element cation homeostasis (HP:0011030)1.63577530
129Spastic tetraparesis (HP:0001285)1.62875371
130Obstructive sleep apnea (HP:0002870)1.62658745
131Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.62128034
132Albinism (HP:0001022)1.61788149
133Neuronal loss in central nervous system (HP:0002529)1.58746797
134Pallor (HP:0000980)1.56737080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.54209095
2TAOK23.52320920
3MAP3K113.41112875
4EPHA43.22900186
5NTRK33.17760785
6MAP3K92.86519409
7MARK12.82708845
8MAP2K32.78976355
9DAPK22.45770753
10PAK62.38363182
11KSR22.23222675
12PRKD32.20206125
13NTRK12.10466484
14MAP3K31.99376422
15MINK11.96310665
16GRK51.89765913
17BRSK11.81282806
18UHMK11.76472151
19CAMKK11.70610271
20MAP3K41.69465953
21TAOK11.68124001
22CDK51.64055229
23NTRK21.58551918
24PIM11.57296935
25SGK4941.52966483
26SGK2231.52966483
27HIPK21.49942629
28CAMK1D1.47949165
29MAPKAPK51.33583360
30DYRK31.33343091
31PKN11.30757058
32PHKG11.29240431
33PHKG21.29240431
34CDK191.22216392
35CDK151.20431850
36MAPK131.18870310
37CDK141.15493705
38CDK181.13124065
39BMX1.12577248
40RET1.11244925
41GRK61.08809871
42KSR11.05200942
43PRPF4B1.05124417
44TLK11.04957155
45CDK11A1.04956234
46SIK21.04062271
47CDC42BPA1.03690105
48TYRO31.02185282
49SGK31.01704635
50OXSR11.00992258
51PRKCH1.00956498
52ALK1.00804926
53WNK10.99529547
54MAP2K40.97378048
55DAPK30.96874764
56DYRK20.96521322
57MAP3K20.93895884
58MAP2K70.93528288
59STK390.92353737
60STK110.90912613
61CAMK40.89938001
62ERBB20.89816554
63PDPK10.88121726
64MAP3K50.87868212
65SGK10.87310402
66PTK2B0.86392451
67TRIB30.86345571
68IKBKE0.85116842
69STK40.84989664
70PDK10.83954390
71ICK0.82797274
72RPS6KA20.81407296
73SCYL20.80006358
74BRAF0.79101810
75EEF2K0.76705464
76SGK20.72544756
77FES0.71902994
78SYK0.70573788
79PINK10.69376975
80MARK20.68938414
81MARK30.67784650
82MAPK120.67551552
83PRKCG0.67381675
84PLK20.66458299
85CAMK1G0.65737406
86PAK30.65469610
87RPS6KA30.64921980
88MAP2K10.64723021
89CAMK2B0.64358112
90RPS6KA50.63912527
91DAPK10.63212548
92RPS6KL10.63162749
93RPS6KC10.63162749
94CAMKK20.62701685
95CAMK2A0.61982384
96STK380.60957666
97CSNK1D0.60178950
98LIMK10.59101519
99ROCK20.58895991
100RIPK40.58724800
101DYRK1A0.58671657
102MOS0.58466980
103CAMK10.57694636
104CASK0.57494587
105FGR0.57485819
106TNIK0.56842049
107PRKAA10.56819673
108MAPK110.53964534
109TNK20.53335663
110MAP3K10.52657884
111ARAF0.52251231
112RPS6KA60.51930580
113PRKD20.51507819
114WNK40.50991791
115CDK120.49111819
116PRKCZ0.48676263
117CSNK1G20.48675381
118MAPK100.47011978
119FYN0.45801987
120RIPK10.45760296
121JAK20.44478411
122DYRK1B0.44185284
123GRK70.43894733
124MAP3K130.43237070
125SIK30.42759318
126RAF10.42513852
127LMTK20.42014733
128CHUK0.38000673
129PRKAA20.37996741
130PLK30.33061559
131IKBKB0.32380688

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.44697638
2Vitamin B6 metabolism_Homo sapiens_hsa007503.41212577
3Synaptic vesicle cycle_Homo sapiens_hsa047212.76936250
4Olfactory transduction_Homo sapiens_hsa047402.49509945
5GABAergic synapse_Homo sapiens_hsa047272.46765550
6Nicotine addiction_Homo sapiens_hsa050332.44598573
7Morphine addiction_Homo sapiens_hsa050322.17637102
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16446519
9Circadian entrainment_Homo sapiens_hsa047132.15808778
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.13751666
11Glutamatergic synapse_Homo sapiens_hsa047242.13195844
12Long-term potentiation_Homo sapiens_hsa047202.09343291
13Nitrogen metabolism_Homo sapiens_hsa009102.04011159
14Regulation of autophagy_Homo sapiens_hsa041402.00709138
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97270810
16Salivary secretion_Homo sapiens_hsa049701.95671800
17Alcoholism_Homo sapiens_hsa050341.89436185
18Collecting duct acid secretion_Homo sapiens_hsa049661.82160214
19Amphetamine addiction_Homo sapiens_hsa050311.74329029
20Dopaminergic synapse_Homo sapiens_hsa047281.71579090
21Gastric acid secretion_Homo sapiens_hsa049711.66444491
22Systemic lupus erythematosus_Homo sapiens_hsa053221.63244943
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62725703
24Insulin secretion_Homo sapiens_hsa049111.61427458
25Cholinergic synapse_Homo sapiens_hsa047251.60982328
26Malaria_Homo sapiens_hsa051441.58844054
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51889483
28Gap junction_Homo sapiens_hsa045401.44656051
29Glioma_Homo sapiens_hsa052141.44282650
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44174124
31Oxytocin signaling pathway_Homo sapiens_hsa049211.42958059
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41091378
33Long-term depression_Homo sapiens_hsa047301.40418414
34Cocaine addiction_Homo sapiens_hsa050301.35142567
35Renin secretion_Homo sapiens_hsa049241.34086720
36Dorso-ventral axis formation_Homo sapiens_hsa043201.33397211
37African trypanosomiasis_Homo sapiens_hsa051431.25562189
38GnRH signaling pathway_Homo sapiens_hsa049121.18052518
39Type II diabetes mellitus_Homo sapiens_hsa049301.17751127
40Serotonergic synapse_Homo sapiens_hsa047261.16179358
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15945810
42Taste transduction_Homo sapiens_hsa047421.13932346
43Non-small cell lung cancer_Homo sapiens_hsa052231.11466774
44Calcium signaling pathway_Homo sapiens_hsa040201.11218209
45Axon guidance_Homo sapiens_hsa043601.06064842
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05944293
47cAMP signaling pathway_Homo sapiens_hsa040241.04410954
48FoxO signaling pathway_Homo sapiens_hsa040681.02440521
49Oocyte meiosis_Homo sapiens_hsa041140.99901891
50Estrogen signaling pathway_Homo sapiens_hsa049150.99717664
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98624715
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98098506
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.94329803
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94173032
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93136629
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92609626
57ErbB signaling pathway_Homo sapiens_hsa040120.92500597
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92204186
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.90107534
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89694644
61Renal cell carcinoma_Homo sapiens_hsa052110.87821455
62Endocytosis_Homo sapiens_hsa041440.84868880
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79050089
64Dilated cardiomyopathy_Homo sapiens_hsa054140.78917202
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78546851
66Cardiac muscle contraction_Homo sapiens_hsa042600.78003104
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76055718
68HIF-1 signaling pathway_Homo sapiens_hsa040660.75307276
69Melanogenesis_Homo sapiens_hsa049160.74963410
70MAPK signaling pathway_Homo sapiens_hsa040100.74954661
71Acute myeloid leukemia_Homo sapiens_hsa052210.74783679
72Choline metabolism in cancer_Homo sapiens_hsa052310.74567635
73Prolactin signaling pathway_Homo sapiens_hsa049170.73952378
74Bladder cancer_Homo sapiens_hsa052190.73895632
75Pancreatic secretion_Homo sapiens_hsa049720.73832979
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72404956
77Bile secretion_Homo sapiens_hsa049760.70470925
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68412221
79B cell receptor signaling pathway_Homo sapiens_hsa046620.64496526
80Notch signaling pathway_Homo sapiens_hsa043300.63544527
81Thyroid hormone synthesis_Homo sapiens_hsa049180.61925801
82Chronic myeloid leukemia_Homo sapiens_hsa052200.60197573
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.57441724
84VEGF signaling pathway_Homo sapiens_hsa043700.56762592
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54617390
86mTOR signaling pathway_Homo sapiens_hsa041500.54327397
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.53735104
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50702031
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50446724
90Melanoma_Homo sapiens_hsa052180.50335400
91AMPK signaling pathway_Homo sapiens_hsa041520.49542005
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48607446
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48584840
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48458619
95Osteoclast differentiation_Homo sapiens_hsa043800.47623681
96Ras signaling pathway_Homo sapiens_hsa040140.47553390
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.47459105
98Endometrial cancer_Homo sapiens_hsa052130.47169325
99Phototransduction_Homo sapiens_hsa047440.46661568
100Circadian rhythm_Homo sapiens_hsa047100.46515223
101Pancreatic cancer_Homo sapiens_hsa052120.45485095
102ABC transporters_Homo sapiens_hsa020100.45439114
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44675123
104Insulin signaling pathway_Homo sapiens_hsa049100.43065194
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42015535
106Platelet activation_Homo sapiens_hsa046110.41176831
107Chemokine signaling pathway_Homo sapiens_hsa040620.40627463
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39618432
109Prion diseases_Homo sapiens_hsa050200.39575463
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.39219334
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38466363
112Inositol phosphate metabolism_Homo sapiens_hsa005620.37227691
113Glucagon signaling pathway_Homo sapiens_hsa049220.36351134
114Ether lipid metabolism_Homo sapiens_hsa005650.36318737
115Rap1 signaling pathway_Homo sapiens_hsa040150.36281295
116Ovarian steroidogenesis_Homo sapiens_hsa049130.35171614
117Tight junction_Homo sapiens_hsa045300.35023504
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33939753

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