TMBIM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.23230703
2COPI coating of Golgi vesicle (GO:0048205)7.23230703
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.88100037
4L-phenylalanine catabolic process (GO:0006559)5.88100037
5L-phenylalanine metabolic process (GO:0006558)5.67655332
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.67655332
7aromatic amino acid family catabolic process (GO:0009074)5.24461741
8alpha-linolenic acid metabolic process (GO:0036109)5.02695135
9cysteine metabolic process (GO:0006534)4.96295178
10glyoxylate metabolic process (GO:0046487)4.92844618
11sulfur amino acid catabolic process (GO:0000098)4.82771758
12lysine metabolic process (GO:0006553)4.76947580
13lysine catabolic process (GO:0006554)4.76947580
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.69789707
15tryptophan catabolic process (GO:0006569)4.68298521
16indole-containing compound catabolic process (GO:0042436)4.68298521
17indolalkylamine catabolic process (GO:0046218)4.68298521
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.63615853
19kynurenine metabolic process (GO:0070189)4.51025298
20tryptophan metabolic process (GO:0006568)4.46174343
21bile acid biosynthetic process (GO:0006699)4.39132967
22homocysteine metabolic process (GO:0050667)4.16738852
23drug transmembrane transport (GO:0006855)4.13646182
24urea metabolic process (GO:0019627)4.13391486
25urea cycle (GO:0000050)4.13391486
26peptidyl-glutamic acid carboxylation (GO:0017187)4.11251786
27protein carboxylation (GO:0018214)4.11251786
28high-density lipoprotein particle remodeling (GO:0034375)4.05572202
29COPII vesicle coating (GO:0048208)4.03327018
30amyloid precursor protein catabolic process (GO:0042987)4.01151556
31amino-acid betaine metabolic process (GO:0006577)3.99808348
32urate metabolic process (GO:0046415)3.95649346
33drug catabolic process (GO:0042737)3.94295557
34cellular modified amino acid catabolic process (GO:0042219)3.86133424
35complement activation, alternative pathway (GO:0006957)3.85530360
36serine family amino acid catabolic process (GO:0009071)3.81808506
37retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.80950266
38reverse cholesterol transport (GO:0043691)3.80817922
39nitrogen cycle metabolic process (GO:0071941)3.80515604
40bile acid metabolic process (GO:0008206)3.79702725
41aromatic amino acid family metabolic process (GO:0009072)3.77519223
42regulation of triglyceride catabolic process (GO:0010896)3.76566680
43negative regulation of fibrinolysis (GO:0051918)3.75919188
44regulation of cholesterol homeostasis (GO:2000188)3.73450625
45regulation of cholesterol esterification (GO:0010872)3.69246004
46cellular ketone body metabolic process (GO:0046950)3.66047997
47negative regulation of cholesterol transport (GO:0032375)3.65513401
48negative regulation of sterol transport (GO:0032372)3.65513401
49valine metabolic process (GO:0006573)3.64379867
50ethanol oxidation (GO:0006069)3.64043961
51alpha-amino acid catabolic process (GO:1901606)3.63311838
52short-chain fatty acid metabolic process (GO:0046459)3.62711510
53protein-lipid complex remodeling (GO:0034368)3.58466489
54macromolecular complex remodeling (GO:0034367)3.58466489
55plasma lipoprotein particle remodeling (GO:0034369)3.58466489
56plasma lipoprotein particle clearance (GO:0034381)3.57853932
57regulation of protein activation cascade (GO:2000257)3.57317895
58tyrosine metabolic process (GO:0006570)3.56448031
59drug transport (GO:0015893)3.56435649
60phospholipid efflux (GO:0033700)3.54897105
61cellular glucuronidation (GO:0052695)3.54517433
62glutamate metabolic process (GO:0006536)3.53193174
63cellular amino acid catabolic process (GO:0009063)3.52635072
64fatty acid beta-oxidation (GO:0006635)3.50526305
65aspartate family amino acid catabolic process (GO:0009068)3.46944487
66fatty acid oxidation (GO:0019395)3.45592923
67glycosphingolipid catabolic process (GO:0046479)3.42298245
68benzene-containing compound metabolic process (GO:0042537)3.41787969
69lipid oxidation (GO:0034440)3.40992228
70exogenous drug catabolic process (GO:0042738)3.39243744
71regulation of complement activation (GO:0030449)3.38670833
72regulation of fibrinolysis (GO:0051917)3.38599775
732-oxoglutarate metabolic process (GO:0006103)3.38075979
74response to mercury ion (GO:0046689)3.36453050
75serine family amino acid metabolic process (GO:0009069)3.34176608
76primary alcohol catabolic process (GO:0034310)3.33237105
77triglyceride homeostasis (GO:0070328)3.32839088
78acylglycerol homeostasis (GO:0055090)3.32839088
79acetyl-CoA metabolic process (GO:0006084)3.32452869
80negative regulation of humoral immune response (GO:0002921)3.32321257
81uronic acid metabolic process (GO:0006063)3.32230229
82glucuronate metabolic process (GO:0019585)3.32230229
83cholesterol efflux (GO:0033344)3.31802993
84indolalkylamine metabolic process (GO:0006586)3.29304540
85aldehyde catabolic process (GO:0046185)3.28709951
86epoxygenase P450 pathway (GO:0019373)3.28633323
87bile acid and bile salt transport (GO:0015721)3.28378704
88flavonoid metabolic process (GO:0009812)3.26967226
89regulation of cholesterol biosynthetic process (GO:0045540)3.26259406
90coenzyme catabolic process (GO:0009109)3.25891251
91fatty acid catabolic process (GO:0009062)3.24632508
92negative regulation of complement activation (GO:0045916)3.24615011
93monocarboxylic acid catabolic process (GO:0072329)3.24382499
94phospholipid homeostasis (GO:0055091)3.24091098
95organic acid catabolic process (GO:0016054)3.24079973
96carboxylic acid catabolic process (GO:0046395)3.24079973
97iron ion import (GO:0097286)3.22829046
98carnitine metabolic process (GO:0009437)3.21302075
99regulation of cholesterol metabolic process (GO:0090181)3.20054318
100glycolipid catabolic process (GO:0019377)3.19551278
101positive regulation of lipoprotein lipase activity (GO:0051006)3.19484007
102positive regulation of triglyceride lipase activity (GO:0061365)3.19484007
103ketone body metabolic process (GO:1902224)3.19106868
104serine family amino acid biosynthetic process (GO:0009070)3.16429689
105sphingosine metabolic process (GO:0006670)3.15646489
106negative regulation of protein activation cascade (GO:2000258)3.13868087
107vesicle coating (GO:0006901)3.13856943
108diol metabolic process (GO:0034311)3.12860236
109plasma lipoprotein particle assembly (GO:0034377)3.12243876
110cholesterol homeostasis (GO:0042632)3.11527079
111sterol homeostasis (GO:0055092)3.11217119
112NADH metabolic process (GO:0006734)3.09575044
113cellular biogenic amine catabolic process (GO:0042402)3.09512900
114amine catabolic process (GO:0009310)3.09512900
115glutamine family amino acid biosynthetic process (GO:0009084)3.09032455
116pyrimidine-containing compound transmembrane transport (GO:0072531)3.08848165
117dicarboxylic acid biosynthetic process (GO:0043650)3.08768415
118tricarboxylic acid metabolic process (GO:0072350)3.08587110
119sphingolipid catabolic process (GO:0030149)3.08152396
120low-density lipoprotein particle remodeling (GO:0034374)3.07440017
121membrane lipid catabolic process (GO:0046466)3.04086064
122intestinal epithelial cell development (GO:0060576)3.01279483
123regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.99644645
124L-serine transport (GO:0015825)2.99226749
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.94840031
126fatty acid elongation (GO:0030497)2.91728195
127ER overload response (GO:0006983)2.91377663
128ethanol metabolic process (GO:0006067)2.89525878
129amyloid precursor protein metabolic process (GO:0042982)2.88946730
130sphingomyelin metabolic process (GO:0006684)2.86045968
131ceramide catabolic process (GO:0046514)2.81357037
132keratan sulfate catabolic process (GO:0042340)2.79519574
133oligosaccharide catabolic process (GO:0009313)2.76252423
134regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74862154
135very long-chain fatty acid metabolic process (GO:0000038)2.74610706
136tricarboxylic acid cycle (GO:0006099)2.70966674
137membrane protein ectodomain proteolysis (GO:0006509)2.70200349
138NADPH regeneration (GO:0006740)2.66831681
139beta-amyloid metabolic process (GO:0050435)2.66691759
140sphingoid metabolic process (GO:0046519)2.66570843
141long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.65823053
142fat-soluble vitamin biosynthetic process (GO:0042362)2.64185485
143peptide catabolic process (GO:0043171)2.60196577
144serine transport (GO:0032329)2.59740428
145xenobiotic catabolic process (GO:0042178)2.58867360
146desmosome organization (GO:0002934)2.56367627
147proline biosynthetic process (GO:0006561)2.54193882
148branched-chain amino acid catabolic process (GO:0009083)2.54087048
149protein maturation by protein folding (GO:0022417)2.53066973
150glycoside metabolic process (GO:0016137)2.52941759
151regulation of autophagic vacuole assembly (GO:2000785)2.50537377
152protein localization to endosome (GO:0036010)2.49034920
153protein retention in ER lumen (GO:0006621)2.46662876
154cellular copper ion homeostasis (GO:0006878)2.46170007
155primary alcohol metabolic process (GO:0034308)2.45270813
156angiotensin maturation (GO:0002003)2.45079397
157axonemal dynein complex assembly (GO:0070286)2.43616369
158positive regulation of cellular amine metabolic process (GO:0033240)2.43437062
159positive regulation of glycoprotein metabolic process (GO:1903020)2.42078192
160activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41650122
161fatty-acyl-CoA biosynthetic process (GO:0046949)2.40536345
162macroautophagy (GO:0016236)2.40314118
163retinol metabolic process (GO:0042572)2.40175693
164zinc ion transport (GO:0006829)2.40063262
165multicellular organismal water homeostasis (GO:0050891)2.39574827
166regulation of integrin-mediated signaling pathway (GO:2001044)2.38652551
167pentose-phosphate shunt (GO:0006098)2.38539463
168regulation of metalloenzyme activity (GO:0048552)2.37551369
169cellular aldehyde metabolic process (GO:0006081)2.37547083
170vitamin transmembrane transport (GO:0035461)2.37501654
171cell adhesion mediated by integrin (GO:0033627)2.36479316
172endoplasmic reticulum unfolded protein response (GO:0030968)2.34470385
173retinal metabolic process (GO:0042574)2.34292187
174eosinophil chemotaxis (GO:0048245)2.31936047
175transferrin transport (GO:0033572)2.31378084
176transcytosis (GO:0045056)2.30831904
177UDP-N-acetylglucosamine metabolic process (GO:0006047)2.30745386
178ferric iron transport (GO:0015682)2.29540116
179trivalent inorganic cation transport (GO:0072512)2.29540116
180epithelial cell differentiation involved in prostate gland development (GO:0060742)2.29475656
181regulation of extracellular matrix disassembly (GO:0010715)2.29230382
182regulation of vacuole organization (GO:0044088)2.28942903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.57974385
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.26358344
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.54602117
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.02584666
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.77177193
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.29089481
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.80643388
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.36076237
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.05598367
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.67731422
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57298369
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39904275
13CLOCK_20551151_ChIP-Seq_293T_Human2.36300659
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.26996884
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21021296
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94323965
17* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87392539
18TFEB_21752829_ChIP-Seq_HELA_Human1.86029400
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85401854
20PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81924569
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81535027
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78095648
23GATA1_22025678_ChIP-Seq_K562_Human1.77297389
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76792618
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75217895
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.73409939
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72119032
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.67285762
29AR_21909140_ChIP-Seq_LNCAP_Human1.62754734
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60345350
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55915752
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.55341662
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.55087741
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50454843
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49230565
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48043758
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47965922
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47965922
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.46747794
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43808723
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38128477
42ELF5_23300383_ChIP-Seq_T47D_Human1.37533359
43* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.35533024
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34671141
45GATA4_25053715_ChIP-Seq_YYC3_Human1.32363789
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31393693
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29048523
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.28400126
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27598550
50LXR_22292898_ChIP-Seq_THP-1_Human1.25346561
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24699687
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23891262
53EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23403900
54* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23068227
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.22875829
56* HNF4A_19822575_ChIP-Seq_HepG2_Human1.19079653
57* IRF8_27001747_Chip-Seq_BMDM_Mouse1.18361680
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.18346172
59* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16534441
60* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16062765
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16062559
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15938210
63SOX2_20726797_ChIP-Seq_SW620_Human1.15435428
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13654927
65CDX2_20551321_ChIP-Seq_CACO-2_Human1.12331965
66EOMES_21245162_ChIP-Seq_HESCs_Human1.11052602
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.10203177
68RACK7_27058665_Chip-Seq_MCF-7_Human1.07087529
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05422776
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02982758
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.02847592
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02296552
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.00422343
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99737963
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98591314
76NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98532795
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98435049
78DCP1A_22483619_ChIP-Seq_HELA_Human0.98169339
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96696089
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96109439
81SMAD_19615063_ChIP-ChIP_OVARY_Human0.94906346
82GATA1_19941826_ChIP-Seq_K562_Human0.94811786
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94446303
84GATA6_25053715_ChIP-Seq_YYC3_Human0.94228036
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93939360
86BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93073909
87GATA2_19941826_ChIP-Seq_K562_Human0.92890457
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92385805
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91880905
90E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91680658
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89718760
92MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89662001
93* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89243951
94ESR1_20079471_ChIP-ChIP_T-47D_Human0.88212690
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87829116
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87098158
97CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87039214
98GABP_17652178_ChIP-ChIP_JURKAT_Human0.86455992
99FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86285404
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85818312
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85818312
102EGR1_19032775_ChIP-ChIP_M12_Human0.83972418
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82654972
104ZNF263_19887448_ChIP-Seq_K562_Human0.81858432
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.80996828
106P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80955361
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80213653
108RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79096906
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78673304
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77220301
111* TBX20_22080862_ChIP-Seq_HEART_Mouse0.76961368
112* TBX20_22328084_ChIP-Seq_HEART_Mouse0.76961368
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75739474
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.74357944
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.74334294
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.74071670
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73860864
118STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.73010115
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72625397
120RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.71928782
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70930195
122FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70483170
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70102135
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.69185053
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68059556
126IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.67742163
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67741986
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67032924
129BCOR_27268052_Chip-Seq_Bcells_Human0.65610852
130MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.65377309
131* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.63651907
132* ATF3_27146783_Chip-Seq_COLON_Human0.63268928
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.63223649
134GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.63213943
135SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61995249
136RUNX_20019798_ChIP-Seq_JUKART_Human0.61928414
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61700349
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.61361164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.58518940
2MP0002139_abnormal_hepatobiliary_system6.54565820
3MP0005365_abnormal_bile_salt4.57944739
4MP0005085_abnormal_gallbladder_physiolo4.53780918
5MP0008875_abnormal_xenobiotic_pharmacok4.17553342
6MP0003252_abnormal_bile_duct3.28283241
7MP0009840_abnormal_foam_cell3.27412592
8MP0003806_abnormal_nucleotide_metabolis3.06854510
9MP0010329_abnormal_lipoprotein_level2.92653750
10MP0005332_abnormal_amino_acid2.88530318
11MP0003195_calcinosis2.78257729
12MP0003191_abnormal_cellular_cholesterol2.70810957
13MP0001666_abnormal_nutrient_absorption2.52583172
14MP0004019_abnormal_vitamin_homeostasis2.46602993
15MP0002138_abnormal_hepatobiliary_system2.39003605
16MP0009780_abnormal_chondrocyte_physiolo2.38023294
17MP0005083_abnormal_biliary_tract2.32657736
18MP0010678_abnormal_skin_adnexa2.19213592
19MP0009643_abnormal_urine_homeostasis2.06464976
20MP0005058_abnormal_lysosome_morphology2.05293879
21MP0002118_abnormal_lipid_homeostasis1.90273785
22MP0000609_abnormal_liver_physiology1.86959477
23MP0004043_abnormal_pH_regulation1.76627862
24MP0005319_abnormal_enzyme/_coenzyme1.70114894
25MP0010352_gastrointestinal_tract_polyps1.59921118
26MP0005584_abnormal_enzyme/coenzyme_acti1.59317834
27MP0003300_gastrointestinal_ulcer1.59015783
28MP0002877_abnormal_melanocyte_morpholog1.52758456
29MP0003186_abnormal_redox_activity1.48007344
30MP0003705_abnormal_hypodermis_morpholog1.46693886
31MP0000604_amyloidosis1.41964189
32MP0005248_abnormal_Harderian_gland1.40692350
33MP0001756_abnormal_urination1.38629530
34MP0008260_abnormal_autophagy1.38536932
35MP0002909_abnormal_adrenal_gland1.36380826
36MP0005636_abnormal_mineral_homeostasis1.36318548
37MP0002098_abnormal_vibrissa_morphology1.35602492
38MP0001853_heart_inflammation1.33035448
39MP0001764_abnormal_homeostasis1.29382309
40MP0010234_abnormal_vibrissa_follicle1.28377713
41MP0000383_abnormal_hair_follicle1.27676024
42MP0009764_decreased_sensitivity_to1.24018284
43MP0003724_increased_susceptibility_to1.21740205
44MP0002136_abnormal_kidney_physiology1.21219095
45MP0002090_abnormal_vision1.17820272
46MP0000627_abnormal_mammary_gland1.15859768
47MP0001765_abnormal_ion_homeostasis1.12508523
48MP0003329_amyloid_beta_deposits1.11861548
49MP0004782_abnormal_surfactant_physiolog1.11734800
50MP0003436_decreased_susceptibility_to1.11187917
51MP0002254_reproductive_system_inflammat1.10441344
52MP0008469_abnormal_protein_level1.10252243
53MP0000377_abnormal_hair_follicle1.07885027
54MP0001216_abnormal_epidermal_layer1.07366064
55MP0000858_altered_metastatic_potential1.05516725
56MP0003690_abnormal_glial_cell1.05170859
57MP0000598_abnormal_liver_morphology1.04561765
58MP0005451_abnormal_body_composition1.04019782
59MP0005501_abnormal_skin_physiology1.03220768
60MP0002166_altered_tumor_susceptibility1.02493527
61MP0003868_abnormal_feces_composition1.02149336
62MP0002148_abnormal_hypersensitivity_rea1.00557553
63MP0006082_CNS_inflammation1.00109470
64MP0003656_abnormal_erythrocyte_physiolo0.99777791
65MP0002132_abnormal_respiratory_system0.98351478
66MP0005310_abnormal_salivary_gland0.97986433
67MP0005167_abnormal_blood-brain_barrier0.96595238
68MP0005670_abnormal_white_adipose0.96271648
69MP0001727_abnormal_embryo_implantation0.95497358
70* MP0005165_increased_susceptibility_to0.93775631
71MP0005408_hypopigmentation0.91269001
72MP0003011_delayed_dark_adaptation0.89847483
73MP0005464_abnormal_platelet_physiology0.89781444
74MP0003172_abnormal_lysosome_physiology0.89662843
75MP0009642_abnormal_blood_homeostasis0.89319893
76MP0001958_emphysema0.87203190
77MP0003941_abnormal_skin_development0.86854786
78MP0009763_increased_sensitivity_to0.86578086
79MP0004264_abnormal_extraembryonic_tissu0.85172913
80MP0003866_abnormal_defecation0.84620209
81MP0001873_stomach_inflammation0.82300932
82MP0005379_endocrine/exocrine_gland_phen0.79812646
83MP0004130_abnormal_muscle_cell0.79730511
84MP0005084_abnormal_gallbladder_morpholo0.79582011
85MP0005220_abnormal_exocrine_pancreas0.79545290
86MP0000427_abnormal_hair_cycle0.78983796
87* MP0003075_altered_response_to0.78290407
88MP0002078_abnormal_glucose_homeostasis0.77879650
89MP0002876_abnormal_thyroid_physiology0.77727809
90MP0002896_abnormal_bone_mineralization0.75953800
91MP0004947_skin_inflammation0.75952917
92MP0001845_abnormal_inflammatory_respons0.74985303
93MP0000516_abnormal_urinary_system0.74684896
94MP0005367_renal/urinary_system_phenotyp0.74684896
95MP0000920_abnormal_myelination0.74401082
96MP0003448_altered_tumor_morphology0.74284000
97MP0010368_abnormal_lymphatic_system0.73979683
98MP0003183_abnormal_peptide_metabolism0.73461842
99MP0004883_abnormal_blood_vessel0.73050426
100MP0005647_abnormal_sex_gland0.72831478
101MP0004272_abnormal_basement_membrane0.72711456
102MP0002971_abnormal_brown_adipose0.72198525
103MP0005166_decreased_susceptibility_to0.71709217
104MP0001533_abnormal_skeleton_physiology0.71437682
105MP0005535_abnormal_body_temperature0.69401384
106MP0002419_abnormal_innate_immunity0.69164188
107MP0009785_altered_susceptibility_to0.68390967
108MP0002168_other_aberrant_phenotype0.67890474
109MP0005666_abnormal_adipose_tissue0.67525569
110MP0003303_peritoneal_inflammation0.67100824
111MP0009765_abnormal_xenobiotic_induced0.66298366
112MP0001835_abnormal_antigen_presentation0.66176577
113MP0005376_homeostasis/metabolism_phenot0.63332952
114MP0003638_abnormal_response/metabolism_0.62792899
115MP0005334_abnormal_fat_pad0.62381722
116MP0002928_abnormal_bile_duct0.62167023
117MP0005025_abnormal_response_to0.61226376
118MP0008438_abnormal_cutaneous_collagen0.60537080
119MP0002796_impaired_skin_barrier0.58736486
120MP0006036_abnormal_mitochondrial_physio0.58639537
121MP0010155_abnormal_intestine_physiology0.58503410
122MP0002135_abnormal_kidney_morphology0.56637275
123MP0000685_abnormal_immune_system0.56417426
124MP0000249_abnormal_blood_vessel0.56263705
125MP0003453_abnormal_keratinocyte_physiol0.55620002
126MP0006054_spinal_hemorrhage0.55394087
127MP0003566_abnormal_cell_adhesion0.55140936
128MP0001881_abnormal_mammary_gland0.55062321
129MP0005023_abnormal_wound_healing0.55042488
130MP0009384_cardiac_valve_regurgitation0.54711375
131MP0005164_abnormal_response_to0.53904641
132MP0000230_abnormal_systemic_arterial0.53327750
133MP0000343_altered_response_to0.52026791
134MP0002295_abnormal_pulmonary_circulatio0.51751188

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.36562813
2Abnormality of glycolipid metabolism (HP:0010969)5.13543682
3Abnormality of liposaccharide metabolism (HP:0010968)5.13543682
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.13543682
5Deep venous thrombosis (HP:0002625)5.05962427
6Intrahepatic cholestasis (HP:0001406)5.01549325
7Xanthomatosis (HP:0000991)4.95577590
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.68022063
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.43417451
10Hyperglycinuria (HP:0003108)4.00539363
11Hypobetalipoproteinemia (HP:0003563)3.97867382
12Gout (HP:0001997)3.92613746
13Ketosis (HP:0001946)3.85404063
14Complement deficiency (HP:0004431)3.84372271
15Loss of speech (HP:0002371)3.77778601
16Prolonged partial thromboplastin time (HP:0003645)3.76278268
17Hyperammonemia (HP:0001987)3.71328304
18Abnormality of glycine metabolism (HP:0010895)3.69340483
19Abnormality of serine family amino acid metabolism (HP:0010894)3.69340483
20Hyperlipoproteinemia (HP:0010980)3.67255934
21Abnormality of purine metabolism (HP:0004352)3.48389255
22Abnormality of fatty-acid metabolism (HP:0004359)3.47256277
23Hypoglycemic coma (HP:0001325)3.45116650
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.42209269
25Joint hemorrhage (HP:0005261)3.38045899
26Ketoacidosis (HP:0001993)3.37497441
27Abnormality of the common coagulation pathway (HP:0010990)3.35863371
28Hypokinesia (HP:0002375)3.35004229
29Fat malabsorption (HP:0002630)3.24597282
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.24238569
31Hyperglycinemia (HP:0002154)3.21434035
32Hypolipoproteinemia (HP:0010981)3.10638085
33Epidermoid cyst (HP:0200040)3.07708304
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.05694826
35Abnormality of nucleobase metabolism (HP:0010932)3.03953330
36Systemic lupus erythematosus (HP:0002725)2.96403994
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.91872032
38Rhinitis (HP:0012384)2.86887874
39Abnormality of the intrinsic pathway (HP:0010989)2.86325995
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.86123676
41Hyperactive renin-angiotensin system (HP:0000841)2.84801647
42Abnormality of complement system (HP:0005339)2.84639033
43Vascular calcification (HP:0004934)2.84507336
44Generalized aminoaciduria (HP:0002909)2.83383702
45Hydroxyprolinuria (HP:0003080)2.83306737
46Abnormality of proline metabolism (HP:0010907)2.83306737
47Alkalosis (HP:0001948)2.81430776
48Increased cerebral lipofuscin (HP:0011813)2.80861366
49Hypoalphalipoproteinemia (HP:0003233)2.80694122
50Hypokalemic alkalosis (HP:0001949)2.74321811
51Increased CSF protein (HP:0002922)2.71152504
52Vacuolated lymphocytes (HP:0001922)2.65127296
53Increased purine levels (HP:0004368)2.63156341
54Hyperuricemia (HP:0002149)2.63156341
55Myocardial infarction (HP:0001658)2.62755556
56Progressive neurologic deterioration (HP:0002344)2.61763646
57Hypercholesterolemia (HP:0003124)2.61138638
58Proximal tubulopathy (HP:0000114)2.60310604
59Cardiovascular calcification (HP:0011915)2.57373390
60Conjugated hyperbilirubinemia (HP:0002908)2.55153153
61Abnormality of methionine metabolism (HP:0010901)2.53878455
62Cholecystitis (HP:0001082)2.53620809
63Abnormal gallbladder physiology (HP:0012438)2.53620809
64Delayed CNS myelination (HP:0002188)2.51252200
65Abnormality of macrophages (HP:0004311)2.49491981
66Recurrent gram-negative bacterial infections (HP:0005420)2.46933312
67Steatorrhea (HP:0002570)2.44763631
68Metabolic acidosis (HP:0001942)2.44530551
69Hyperbilirubinemia (HP:0002904)2.44300611
70Nuclear cataract (HP:0100018)2.43060575
71Malnutrition (HP:0004395)2.42881641
72Hepatocellular carcinoma (HP:0001402)2.41590091
73Right ventricular cardiomyopathy (HP:0011663)2.40816951
74Mucopolysacchariduria (HP:0008155)2.37872046
75Urinary glycosaminoglycan excretion (HP:0003541)2.37872046
76Dicarboxylic aciduria (HP:0003215)2.37252298
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37252298
78Sensorimotor neuropathy (HP:0007141)2.34546971
79Abnormality of chloride homeostasis (HP:0011422)2.33798490
80Esophageal varix (HP:0002040)2.33229785
81Dysostosis multiplex (HP:0000943)2.32058868
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.31223559
83Osteolytic defects of the hand bones (HP:0009699)2.31223559
84Amyloidosis (HP:0011034)2.30299889
85Abnormality of the distal phalanges of the toes (HP:0010182)2.30212198
86Vertebral compression fractures (HP:0002953)2.29262543
87Cardiomegaly (HP:0001640)2.29237668
88Metabolic alkalosis (HP:0200114)2.27343425
89Spastic diplegia (HP:0001264)2.26384418
90Irritability (HP:0000737)2.24749853
91Late onset (HP:0003584)2.20250644
92Mitral stenosis (HP:0001718)2.20196987
93Glomerulonephritis (HP:0000099)2.19440383
94Abnormality of polysaccharide metabolism (HP:0011012)2.17021987
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17021987
96Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17021987
97Abnormal enzyme/coenzyme activity (HP:0012379)2.16145814
98Hypoglycemic seizures (HP:0002173)2.15254876
99Abnormality of pyrimidine metabolism (HP:0004353)2.15081478
100Increased circulating renin level (HP:0000848)2.14423230
101Skin nodule (HP:0200036)2.14338157
102Axonal loss (HP:0003447)2.14054433
103Pancreatitis (HP:0001733)2.13633646
104Abnormal respiratory motile cilium physiology (HP:0012261)2.13580284
105J-shaped sella turcica (HP:0002680)2.10971836
106Chronic bronchitis (HP:0004469)2.10822552
107Micronodular cirrhosis (HP:0001413)2.10773193
108Neurofibrillary tangles (HP:0002185)2.09904013
109Hepatosplenomegaly (HP:0001433)2.08769578
110Abnormal respiratory epithelium morphology (HP:0012253)2.06664459
111Abnormal respiratory motile cilium morphology (HP:0005938)2.06664459
112Prolonged neonatal jaundice (HP:0006579)2.04637928
113Abnormal urine output (HP:0012590)2.04509316
114Increased neuronal autofluorescent lipopigment (HP:0002074)2.04274574
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03313089
116Short nail (HP:0001799)2.03192119
117Interstitial pulmonary disease (HP:0006530)2.02171888
118Vomiting (HP:0002013)1.99602608
119Abnormality of renal excretion (HP:0011036)1.99332907
120Nephrolithiasis (HP:0000787)1.99264030
121Lethargy (HP:0001254)1.99117006
122Abnormality of urine glucose concentration (HP:0011016)1.99076074
123Glycosuria (HP:0003076)1.99076074
124Tetraparesis (HP:0002273)1.98910651
125Abnormality of serum amino acid levels (HP:0003112)1.98511800
126Hypotension (HP:0002615)1.98000744
127Protuberant abdomen (HP:0001538)1.97747266
128Abnormality of alkaline phosphatase activity (HP:0004379)1.97623726
129Bronchiectasis (HP:0002110)1.96969593
130Hemorrhage of the eye (HP:0011885)1.93548660
131Abdominal distention (HP:0003270)1.93329529
132Rickets (HP:0002748)1.92572323
133Elevated alkaline phosphatase (HP:0003155)1.90070434
134Abnormality of vitamin metabolism (HP:0100508)1.89815186
135Nephritis (HP:0000123)1.89739907
136Symptomatic seizures (HP:0011145)1.89468955
137Neonatal onset (HP:0003623)1.89016289
138Abnormal gallbladder morphology (HP:0012437)1.88109930
139Beaking of vertebral bodies (HP:0004568)1.87808424
140Renal salt wasting (HP:0000127)1.87403535
141Abnormal ciliary motility (HP:0012262)1.86645962
142Pili torti (HP:0003777)1.82773233
143Abnormality of glycolysis (HP:0004366)1.81512253
144Chronic diarrhea (HP:0002028)1.81105141
145Lower limb hyperreflexia (HP:0002395)1.80144345
146Abnormality of the anterior horn cell (HP:0006802)1.79397560
147Degeneration of anterior horn cells (HP:0002398)1.79397560
148Diminished movement (HP:0002374)1.76904599
149Glucose intolerance (HP:0000833)1.76640772
150Abnormal glucose tolerance (HP:0001952)1.76238164
151Bone pain (HP:0002653)1.75986689
152Autoamputation (HP:0001218)1.75845450
153Nasal polyposis (HP:0100582)1.73660553
154Type I transferrin isoform profile (HP:0003642)1.70355069
155Spastic paraparesis (HP:0002313)1.66396428
156Growth hormone excess (HP:0000845)1.66120920
157Tongue fasciculations (HP:0001308)1.65359775
158Cholelithiasis (HP:0001081)1.64665829
159Increased serum pyruvate (HP:0003542)1.64555703
160Flat acetabular roof (HP:0003180)1.64071731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.89284475
2BCKDK4.25273898
3EIF2AK13.75983605
4MAP3K123.49503406
5SIK13.24691077
6TRIB33.15830878
7FGFR43.06523376
8SCYL22.67997722
9EIF2AK32.50312010
10WNK42.48466835
11EPHB12.39540111
12TAOK32.29657917
13MST1R2.10818264
14PBK1.95789906
15PKN21.88801651
16PTK61.87499358
17OXSR11.82258989
18TYK21.70510116
19TBK11.64236791
20FRK1.60394790
21SIK31.58690231
22NEK61.57848175
23TGFBR21.57758090
24LIMK11.57645299
25MAPKAPK31.56250572
26WNK31.53591438
27INSRR1.52292836
28LRRK21.47047388
29TSSK61.44674670
30RIPK11.43496235
31JAK11.41963928
32BMPR21.35051705
33MAP4K11.24016197
34NEK11.19803028
35YES11.18715496
36TRIM281.17609952
37ERBB31.17248735
38MET1.16415345
39MAPK151.15309154
40STK391.14327102
41MAP3K141.12984072
42JAK21.10040483
43MST41.09474433
44ZAP701.08411307
45CSK1.08066051
46NEK91.07576502
47STK101.06942977
48KDR1.06419088
49ERBB41.06013698
50MAP3K31.04195142
51PTK21.03544689
52MAP3K21.02998963
53GRK61.01759517
54FLT31.01198545
55TTK1.00976612
56PIK3CG0.97689528
57BCR0.97311122
58EPHA30.95656344
59IKBKE0.92688995
60MAP2K30.91280027
61LMTK20.91199142
62MAPK110.90874519
63IRAK30.88553360
64LATS10.88341889
65TIE10.87886990
66BMX0.87564155
67JAK30.85598354
68TESK10.85199032
69PDK20.78826016
70SGK30.78484412
71BLK0.76293058
72PDPK10.75974564
73PAK40.75628321
74PRKCI0.75231831
75CAMK1D0.73708440
76MAP3K70.73584015
77FGFR30.72831750
78FGFR20.72487003
79GSK3A0.70088248
80PDGFRA0.69621304
81ABL20.67326080
82SGK4940.67267842
83SGK2230.67267842
84EPHA20.67099837
85PIM20.66887176
86ROCK20.66768415
87MAP2K20.66293102
88CSF1R0.66032112
89MAP3K100.65885145
90BRSK20.65834903
91ITK0.64706450
92FER0.62666921
93MYLK0.58998907
94DYRK1B0.58522462
95SMG10.56779937
96EEF2K0.56685724
97PRKAA20.56533385
98MAP3K10.56271158
99PRKG20.55954237
100MAPKAPK20.54716616
101PRKCH0.54274716
102KIT0.53659346
103KSR20.51919464
104TAOK10.51567041
105BTK0.50345123
106STK38L0.50272473
107PDK10.50159771
108TTN0.49039966
109RET0.48190247
110PRKCZ0.47774935
111DAPK10.46479231
112DAPK20.46221046
113CAMK2G0.46112504
114CDK60.45551653
115MAP2K10.44860670
116TESK20.44057625
117CAMK2D0.43993143
118ILK0.43206587
119PRKCQ0.43072880
120PRKACG0.41520526
121ERBB20.41082115
122CHUK0.41006997
123MATK0.40610428
124PDK40.40182347
125PDK30.40182347
126FGR0.40020274
127NTRK10.39854414
128IGF1R0.39684488
129ARAF0.39467769
130STK240.38582013
131MAP3K110.37411368
132CLK10.35346006
133AKT20.32185263
134TXK0.31586556
135BRSK10.31213262
136IRAK10.31131736
137TRPM70.28864259
138MAP3K80.28066388
139SRC0.27735917
140TAOK20.27515279
141ABL10.26257268
142NME20.25934025
143PRKCE0.25795306
144STK380.25286684
145PRKD30.24534328
146SRPK10.24183797
147EGFR0.22947905

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.39842335
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34751020
3Nitrogen metabolism_Homo sapiens_hsa009103.25819511
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68769278
5Fatty acid degradation_Homo sapiens_hsa000712.60554721
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56185772
7Tryptophan metabolism_Homo sapiens_hsa003802.53335838
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.49079437
9Arginine biosynthesis_Homo sapiens_hsa002202.46790520
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45745935
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43688233
12Butanoate metabolism_Homo sapiens_hsa006502.21899269
13Peroxisome_Homo sapiens_hsa041462.09075690
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06299689
15Complement and coagulation cascades_Homo sapiens_hsa046102.06280267
16Propanoate metabolism_Homo sapiens_hsa006402.05293904
17Sulfur metabolism_Homo sapiens_hsa009201.98670887
18Fatty acid metabolism_Homo sapiens_hsa012121.95925189
19PPAR signaling pathway_Homo sapiens_hsa033201.90576881
20Proteasome_Homo sapiens_hsa030501.90405775
21Sphingolipid metabolism_Homo sapiens_hsa006001.89986354
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89314972
23Histidine metabolism_Homo sapiens_hsa003401.86666876
24Vibrio cholerae infection_Homo sapiens_hsa051101.78580855
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75837761
26Caffeine metabolism_Homo sapiens_hsa002321.75155706
27beta-Alanine metabolism_Homo sapiens_hsa004101.70445213
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64611717
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64402016
30Staphylococcus aureus infection_Homo sapiens_hsa051501.64112894
31Chemical carcinogenesis_Homo sapiens_hsa052041.63691110
32Bile secretion_Homo sapiens_hsa049761.59865641
33Selenocompound metabolism_Homo sapiens_hsa004501.49886324
34N-Glycan biosynthesis_Homo sapiens_hsa005101.49567909
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48472317
36Pyruvate metabolism_Homo sapiens_hsa006201.47519077
37Starch and sucrose metabolism_Homo sapiens_hsa005001.41596365
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.40558901
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.38059706
40Retinol metabolism_Homo sapiens_hsa008301.31095968
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29353517
42Fatty acid elongation_Homo sapiens_hsa000621.27733108
43Vitamin digestion and absorption_Homo sapiens_hsa049771.25286697
44Phenylalanine metabolism_Homo sapiens_hsa003601.25108638
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24421335
46Fat digestion and absorption_Homo sapiens_hsa049751.24336986
47Carbon metabolism_Homo sapiens_hsa012001.20950771
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.20640222
49Protein export_Homo sapiens_hsa030601.18358664
50ABC transporters_Homo sapiens_hsa020101.17585873
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.17434244
52Folate biosynthesis_Homo sapiens_hsa007901.13028778
53Steroid biosynthesis_Homo sapiens_hsa001001.05231982
54Biosynthesis of amino acids_Homo sapiens_hsa012301.03236526
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02482839
56Tyrosine metabolism_Homo sapiens_hsa003501.01201875
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00817282
58Arginine and proline metabolism_Homo sapiens_hsa003300.97118963
59Glutathione metabolism_Homo sapiens_hsa004800.93454149
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92156311
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90493101
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.88317630
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87156621
64Glycerolipid metabolism_Homo sapiens_hsa005610.85661968
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84238742
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83549571
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83110015
68Lysosome_Homo sapiens_hsa041420.75039649
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74386367
70Sulfur relay system_Homo sapiens_hsa041220.73455194
71Rheumatoid arthritis_Homo sapiens_hsa053230.73335939
72Lysine degradation_Homo sapiens_hsa003100.72843273
73Pentose phosphate pathway_Homo sapiens_hsa000300.72727354
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72681142
75Other glycan degradation_Homo sapiens_hsa005110.67478481
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65022654
77Antigen processing and presentation_Homo sapiens_hsa046120.65013826
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.63170102
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60648911
80Fatty acid biosynthesis_Homo sapiens_hsa000610.59646216
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54407065
82Galactose metabolism_Homo sapiens_hsa000520.51487513
83Fructose and mannose metabolism_Homo sapiens_hsa000510.50083519
84Mineral absorption_Homo sapiens_hsa049780.49081390
85Renin-angiotensin system_Homo sapiens_hsa046140.45186244
86Insulin resistance_Homo sapiens_hsa049310.44478390
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.42423871
88Vitamin B6 metabolism_Homo sapiens_hsa007500.42100314
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41392259
90Salmonella infection_Homo sapiens_hsa051320.40476089
91Shigellosis_Homo sapiens_hsa051310.39514075
92Arachidonic acid metabolism_Homo sapiens_hsa005900.37360146
93Metabolic pathways_Homo sapiens_hsa011000.33966868
94Thyroid cancer_Homo sapiens_hsa052160.31729809
95Endocytosis_Homo sapiens_hsa041440.29853803
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29320273
97Prion diseases_Homo sapiens_hsa050200.28261366
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25866034
99Protein digestion and absorption_Homo sapiens_hsa049740.23786545
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23657160
101Type I diabetes mellitus_Homo sapiens_hsa049400.23148453
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22903899
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16926758
104Thyroid hormone synthesis_Homo sapiens_hsa049180.16560457
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13551494
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.11444420
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11317902
108Hepatitis C_Homo sapiens_hsa051600.11201073
109Pertussis_Homo sapiens_hsa051330.10360083
110One carbon pool by folate_Homo sapiens_hsa006700.09503267
111AMPK signaling pathway_Homo sapiens_hsa041520.05922075
112Amoebiasis_Homo sapiens_hsa051460.05147642
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05139687
114Legionellosis_Homo sapiens_hsa051340.04769482
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.02743669
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.02337241
117Leishmaniasis_Homo sapiens_hsa051400.02010811
118Phagosome_Homo sapiens_hsa041450.01924829
119Collecting duct acid secretion_Homo sapiens_hsa049660.00368230
120Glucagon signaling pathway_Homo sapiens_hsa04922-0.0292827
121Linoleic acid metabolism_Homo sapiens_hsa00591-0.0049120

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