TMBIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.60675213
2central nervous system myelination (GO:0022010)8.60675213
3fatty acid elongation (GO:0030497)5.73550654
4ensheathment of neurons (GO:0007272)4.82641419
5axon ensheathment (GO:0008366)4.82641419
6myelination (GO:0042552)4.73870977
7myelin maintenance (GO:0043217)4.42468028
8long-chain fatty acid biosynthetic process (GO:0042759)4.05179448
9amyloid precursor protein metabolic process (GO:0042982)4.01216877
10adhesion of symbiont to host cell (GO:0044650)4.00120701
11virion attachment to host cell (GO:0019062)4.00120701
12creatine metabolic process (GO:0006600)3.81228113
13import into cell (GO:0098657)3.71060445
14amyloid precursor protein catabolic process (GO:0042987)3.69211614
15eye photoreceptor cell differentiation (GO:0001754)3.46620987
16photoreceptor cell differentiation (GO:0046530)3.46620987
17oligodendrocyte differentiation (GO:0048709)3.45694052
18positive regulation of cellular amine metabolic process (GO:0033240)3.40031757
19membrane raft organization (GO:0031579)3.37050915
20cholesterol biosynthetic process (GO:0006695)3.35767128
21negative regulation of protein localization to cell surface (GO:2000009)3.22805984
22response to lipoprotein particle (GO:0055094)3.21992711
23protein localization to endosome (GO:0036010)3.20784801
24adhesion of symbiont to host (GO:0044406)3.20601041
25GPI anchor biosynthetic process (GO:0006506)3.17099934
26positive regulation of oligodendrocyte differentiation (GO:0048714)3.15546719
27positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.12425089
28barbed-end actin filament capping (GO:0051016)3.11763950
29low-density lipoprotein particle clearance (GO:0034383)3.10251172
30positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.08557817
31long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.07661316
32sphingoid metabolic process (GO:0046519)3.04250932
33Golgi to endosome transport (GO:0006895)3.02802325
34peripheral nervous system axon ensheathment (GO:0032292)3.00820492
35myelination in peripheral nervous system (GO:0022011)3.00820492
36sterol biosynthetic process (GO:0016126)2.99710475
37regulation of lipoprotein metabolic process (GO:0050746)2.99557335
38desmosome organization (GO:0002934)2.99357183
39negative regulation of leukocyte chemotaxis (GO:0002689)2.98799233
40glycosphingolipid catabolic process (GO:0046479)2.87855770
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85196831
42long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.84889606
43response to methylmercury (GO:0051597)2.84637813
44presynaptic membrane assembly (GO:0097105)2.84244847
45GPI anchor metabolic process (GO:0006505)2.83135374
46pinocytosis (GO:0006907)2.82444222
47cellular response to thyroid hormone stimulus (GO:0097067)2.81649475
48hypotonic response (GO:0006971)2.78718853
49glycolipid catabolic process (GO:0019377)2.77845641
50negative regulation of erythrocyte differentiation (GO:0045647)2.77399269
51presynaptic membrane organization (GO:0097090)2.75028177
52isoprenoid biosynthetic process (GO:0008299)2.74426440
53diol metabolic process (GO:0034311)2.74223628
54positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.73599178
55membrane tubulation (GO:0097320)2.73038304
56fatty-acyl-CoA biosynthetic process (GO:0046949)2.72452278
57sphingosine metabolic process (GO:0006670)2.71672072
58very long-chain fatty acid metabolic process (GO:0000038)2.70719676
59response to redox state (GO:0051775)2.69356548
60nucleotide transmembrane transport (GO:1901679)2.68502235
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68439320
62mesodermal cell differentiation (GO:0048333)2.67601969
63enteric nervous system development (GO:0048484)2.66426112
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.66026192
65positive regulation of osteoblast proliferation (GO:0033690)2.65432889
66response to peptidoglycan (GO:0032494)2.63600013
67regulation of cholesterol homeostasis (GO:2000188)2.61528582
68magnesium ion transport (GO:0015693)2.61076000
69peptide catabolic process (GO:0043171)2.60779906
70regulation of membrane protein ectodomain proteolysis (GO:0051043)2.60706646
71sphingomyelin metabolic process (GO:0006684)2.59884618
72L-amino acid import (GO:0043092)2.59319682
73antigen processing and presentation of endogenous antigen (GO:0019883)2.58378693
74astrocyte development (GO:0014002)2.58124432
75regulation of cholesterol storage (GO:0010885)2.58029604
76positive regulation of toll-like receptor signaling pathway (GO:0034123)2.57406448
77fatty-acyl-CoA metabolic process (GO:0035337)2.57301474
78cell-substrate junction assembly (GO:0007044)2.57144633
79positive regulation of cellular amide metabolic process (GO:0034250)2.56869089
80regulation of osteoblast proliferation (GO:0033688)2.55815706
81detection of other organism (GO:0098543)2.55378517
82positive regulation of extracellular matrix organization (GO:1903055)2.55235054
83negative regulation of execution phase of apoptosis (GO:1900118)2.52484930
84negative regulation of neurotransmitter secretion (GO:0046929)2.51724829
85limb bud formation (GO:0060174)2.51717627
86positive regulation of receptor recycling (GO:0001921)2.50155013
87phosphatidylserine acyl-chain remodeling (GO:0036150)2.49778604
88response to thyroid hormone (GO:0097066)2.48599742
89skin morphogenesis (GO:0043589)2.48271566
90glycosylceramide metabolic process (GO:0006677)2.48250052
91oligosaccharide catabolic process (GO:0009313)2.48043176
92positive regulation of Cdc42 GTPase activity (GO:0043089)2.47578070
93regulation of collateral sprouting (GO:0048670)2.46803465
94regulation of macrophage chemotaxis (GO:0010758)2.46386913
95positive regulation of lipoprotein lipase activity (GO:0051006)2.45389325
96positive regulation of triglyceride lipase activity (GO:0061365)2.45389325
97detection of bacterium (GO:0016045)2.44843368
98regulation of somitogenesis (GO:0014807)2.44646010
99hemidesmosome assembly (GO:0031581)2.44488342
100lipopolysaccharide-mediated signaling pathway (GO:0031663)2.43946746
101angiotensin maturation (GO:0002003)2.43317263
102negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.42480309
103negative regulation of cell killing (GO:0031342)2.42480309
104leukocyte migration involved in inflammatory response (GO:0002523)2.40305438
105neutrophil activation involved in immune response (GO:0002283)2.39208379
106stress fiber assembly (GO:0043149)2.38309297
107regulation of vitamin metabolic process (GO:0030656)2.37716808
108negative regulation of chemokine production (GO:0032682)2.37493175
109positive regulation of pseudopodium assembly (GO:0031274)2.37037952
110axon development (GO:0061564)2.36816076
111phosphatidylserine metabolic process (GO:0006658)2.36392143
112positive regulation of glial cell differentiation (GO:0045687)2.36054953
113regulation of early endosome to late endosome transport (GO:2000641)2.34733067
114positive regulation of gliogenesis (GO:0014015)2.34334727
115cell adhesion mediated by integrin (GO:0033627)2.34182460
116interleukin-6-mediated signaling pathway (GO:0070102)2.34079961
117mitochondrial calcium ion homeostasis (GO:0051560)2.33236946
118positive regulation by organism of defense response of other organism involved in symbiotic interact2.33137387
119modulation by symbiont of host immune response (GO:0052553)2.33137387
120positive regulation by symbiont of host defense response (GO:0052509)2.33137387
121modulation by symbiont of host defense response (GO:0052031)2.33137387
122modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.33137387
123modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.33137387
124apoptotic cell clearance (GO:0043277)2.33014392
125membrane protein ectodomain proteolysis (GO:0006509)2.32739460
126surfactant homeostasis (GO:0043129)2.32197979
127T-helper 1 type immune response (GO:0042088)2.32062468
128regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.31831694
129macrophage activation involved in immune response (GO:0002281)2.31679490
130negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30945464
131detection of external biotic stimulus (GO:0098581)2.30731256
132mannose metabolic process (GO:0006013)2.29971104
133glycerophospholipid catabolic process (GO:0046475)2.29901249
134regulation of leukocyte degranulation (GO:0043300)2.29182019
135ceramide catabolic process (GO:0046514)2.28687924
136protein palmitoylation (GO:0018345)2.27686529
137negative regulation of interleukin-12 production (GO:0032695)2.26976058
138signal peptide processing (GO:0006465)2.26757700
139calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.26373370
140regulation of extracellular matrix disassembly (GO:0010715)2.26279863
141detection of molecule of bacterial origin (GO:0032490)2.25682607
142organ growth (GO:0035265)2.25469142
143regulation of pseudopodium assembly (GO:0031272)2.25027058
144mannosylation (GO:0097502)2.24056014
145regulation of pigment cell differentiation (GO:0050932)2.23245904
146membrane assembly (GO:0071709)2.22424265
147preassembly of GPI anchor in ER membrane (GO:0016254)2.22087185
148peptidyl-tyrosine autophosphorylation (GO:0038083)2.21610069
149amino acid import (GO:0043090)2.21340324
150negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.21027204
151regulation of mast cell degranulation (GO:0043304)2.20331055
152thioester biosynthetic process (GO:0035384)2.18907132
153acyl-CoA biosynthetic process (GO:0071616)2.18907132
154omega-hydroxylase P450 pathway (GO:0097267)2.18793819
155positive regulation of gamma-delta T cell activation (GO:0046645)2.18442684
156positive regulation of hemostasis (GO:1900048)2.18274303
157positive regulation of blood coagulation (GO:0030194)2.18274303
158response to laminar fluid shear stress (GO:0034616)2.18201976
159nephron tubule formation (GO:0072079)2.16417399
160positive regulation of coagulation (GO:0050820)2.16004616
161cyclooxygenase pathway (GO:0019371)2.15588988
162positive regulation of endothelial cell apoptotic process (GO:2000353)2.15184922
163regulation of myeloid leukocyte mediated immunity (GO:0002886)2.14640334
164C-terminal protein lipidation (GO:0006501)2.14101639
165glial cell development (GO:0021782)2.13791868
166COPI coating of Golgi vesicle (GO:0048205)2.13417364
167Golgi transport vesicle coating (GO:0048200)2.13417364
168ear development (GO:0043583)2.13032559
169neuron remodeling (GO:0016322)2.12244150
170positive regulation of leukocyte degranulation (GO:0043302)2.12060923
171regulation of cholesterol esterification (GO:0010872)2.11827825
172extracellular matrix assembly (GO:0085029)2.11756059
173regulation of superoxide anion generation (GO:0032928)2.11683355
174negative regulation of acute inflammatory response (GO:0002674)2.11080203
175endodermal cell differentiation (GO:0035987)2.10980498
176fibril organization (GO:0097435)2.09736294
177plasma lipoprotein particle clearance (GO:0034381)2.07607650
178very-low-density lipoprotein particle assembly (GO:0034379)2.07284567
179granulocyte activation (GO:0036230)2.07238340
180protein-lipid complex assembly (GO:0065005)2.06587540
181regulation of water loss via skin (GO:0033561)2.06495376
182regulation of vitamin D biosynthetic process (GO:0060556)2.06330557
183positive regulation of cholesterol efflux (GO:0010875)2.05073321
184negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.04967340
185regulation of necrotic cell death (GO:0010939)2.04890140
186fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.04871068
187decidualization (GO:0046697)2.03958476
188regulation of mononuclear cell migration (GO:0071675)2.03921937
189germinal center formation (GO:0002467)2.03392133
190regulation of transforming growth factor beta1 production (GO:0032908)2.02350721
191hyaluronan catabolic process (GO:0030214)2.02093768
192regulation of extracellular matrix organization (GO:1903053)2.00539332
193fat-soluble vitamin biosynthetic process (GO:0042362)2.00351561
194negative regulation of fibrinolysis (GO:0051918)2.00238613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.83137120
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.99465192
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.98450325
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.71792337
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.55811127
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.51503663
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.49388390
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.42379688
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32603312
10* ELK3_25401928_ChIP-Seq_HUVEC_Human2.04757216
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.02925381
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.00128670
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.98510847
14* GATA2_21666600_ChIP-Seq_HMVEC_Human1.93794213
15LXR_22292898_ChIP-Seq_THP-1_Human1.89893863
16PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85630731
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85553830
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81493215
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80837289
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.78013843
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76742795
22NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.74311677
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.74311677
24CLOCK_20551151_ChIP-Seq_293T_Human1.71554112
25* SOX2_20726797_ChIP-Seq_SW620_Human1.69480044
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64051872
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63424249
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61878825
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58490947
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55802336
31VDR_24763502_ChIP-Seq_THP-1_Human1.54952323
32RACK7_27058665_Chip-Seq_MCF-7_Human1.54501698
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53430416
34* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.52786236
35* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52060076
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51477021
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50431112
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49443941
39* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48827891
40* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48270113
41* SPI1_23127762_ChIP-Seq_K562_Human1.47101954
42* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45273110
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44449470
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44351580
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.43798764
46CJUN_26792858_Chip-Seq_BT549_Human1.43533592
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41442618
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41286307
49VDR_21846776_ChIP-Seq_THP-1_Human1.40631198
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.38799636
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38644549
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.38514736
53* GATA1_19941827_ChIP-Seq_MEL_Mouse1.38366236
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.37128395
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36854200
56* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36730485
57* TCF7_22412390_ChIP-Seq_EML_Mouse1.35412531
58* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35355940
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34530557
60ZNF263_19887448_ChIP-Seq_K562_Human1.33565933
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32762658
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32624200
63AR_21572438_ChIP-Seq_LNCaP_Human1.31084987
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.30823269
65VDR_24787735_ChIP-Seq_THP-1_Human1.30677952
66* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29975507
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28919111
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27966013
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27062644
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.21569431
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21542779
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20492699
73* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18281436
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17535044
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17488852
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17430171
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16605583
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.16354568
79* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12726720
80* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12264994
81RUNX_20019798_ChIP-Seq_JUKART_Human1.12166387
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12035356
83KDM2B_26808549_Chip-Seq_DND41_Human1.11901230
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11121867
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11008660
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10957225
87MAF_26560356_Chip-Seq_TH1_Human1.10095831
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09494506
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09476023
90ATF3_27146783_Chip-Seq_COLON_Human1.08314415
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08183495
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06488673
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05755412
94* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05632716
95IRF8_27001747_Chip-Seq_BMDM_Mouse1.05481656
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04102152
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.04043668
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03282180
99* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02189882
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02009498
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01788573
102ER_23166858_ChIP-Seq_MCF-7_Human1.01525280
103KDM2B_26808549_Chip-Seq_K562_Human1.01058697
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00981506
105IRF8_22096565_ChIP-ChIP_GC-B_Human1.00010663
106* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99943073
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99597646
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99117823
109* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98904375
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98600614
111SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97553771
112TP53_18474530_ChIP-ChIP_U2OS_Human0.96027063
113SMAD_19615063_ChIP-ChIP_OVARY_Human0.95017363
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.94763759
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94533272
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94171970
117* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93423261
118* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93423261
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93237518
120TP53_16413492_ChIP-PET_HCT116_Human0.92450768
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90527602
122* KLF5_25053715_ChIP-Seq_YYC3_Human0.90319118
123MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90126416
124* TP63_23658742_ChIP-Seq_EP156T_Human0.89929930
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89490878
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89433194
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89134064
128EED_16625203_ChIP-ChIP_MESCs_Mouse0.88040210
129MTF2_20144788_ChIP-Seq_MESCs_Mouse0.87387890
130SCL_19346495_ChIP-Seq_HPC-7_Human0.86712078
131* GATA4_25053715_ChIP-Seq_YYC3_Human0.86308985
132IRF8_21731497_ChIP-ChIP_J774_Mouse0.85995357
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85986117
134* GATA1_19941826_ChIP-Seq_K562_Human0.85295280
135ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84998623
136SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84771918
137SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84303420
138EGR1_19032775_ChIP-ChIP_M12_Human0.83524794
139GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82869877
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82480670
141EOMES_21245162_ChIP-Seq_HESCs_Human0.82444095
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81654586
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81624567
144* GATA2_19941826_ChIP-Seq_K562_Human0.81485416
145GATA1_22025678_ChIP-Seq_K562_Human0.79455491
146STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78703791
147LXR_22158963_ChIP-Seq_LIVER_Mouse0.78549487
148SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78236430
149SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.78106237
150TBX20_22328084_ChIP-Seq_HEART_Mouse0.77977985
151TBX20_22080862_ChIP-Seq_HEART_Mouse0.77977985
152SA1_22415368_ChIP-Seq_MEFs_Mouse0.77815397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.09386815
2MP0003950_abnormal_plasma_membrane4.04402968
3MP0003136_yellow_coat_color3.26749598
4MP0008438_abnormal_cutaneous_collagen3.19049833
5MP0004381_abnormal_hair_follicle2.82807924
6MP0003303_peritoneal_inflammation2.55253858
7MP0003436_decreased_susceptibility_to2.54963062
8MP0003724_increased_susceptibility_to2.48539876
9MP0003690_abnormal_glial_cell2.42961220
10MP0005409_darkened_coat_color2.37309861
11MP0003705_abnormal_hypodermis_morpholog2.36270416
12MP0002139_abnormal_hepatobiliary_system2.31562766
13MP0000566_synostosis2.31086842
14MP0003300_gastrointestinal_ulcer2.27264125
15MP0005058_abnormal_lysosome_morphology2.23892734
16MP0005464_abnormal_platelet_physiology2.17911279
17MP0010234_abnormal_vibrissa_follicle2.17112572
18MP0009840_abnormal_foam_cell2.15188948
19MP0008260_abnormal_autophagy2.12647911
20MP0004272_abnormal_basement_membrane2.03440438
21MP0005171_absent_coat_pigmentation2.01583871
22MP0005360_urolithiasis1.99596113
23MP0005275_abnormal_skin_tensile1.92582135
24MP0000383_abnormal_hair_follicle1.92278177
25MP0004947_skin_inflammation1.91107009
26MP0009379_abnormal_foot_pigmentation1.90968997
27MP0005365_abnormal_bile_salt1.79225380
28MP0003172_abnormal_lysosome_physiology1.75419561
29MP0000465_gastrointestinal_hemorrhage1.74729226
30MP0010678_abnormal_skin_adnexa1.73078963
31MP0002933_joint_inflammation1.63751915
32MP0005451_abnormal_body_composition1.63236564
33MP0000858_altered_metastatic_potential1.56958079
34MP0000579_abnormal_nail_morphology1.55107181
35MP0001958_emphysema1.52010477
36MP0003453_abnormal_keratinocyte_physiol1.47191481
37MP0010155_abnormal_intestine_physiology1.46317660
38MP0001835_abnormal_antigen_presentation1.44189469
39MP0009384_cardiac_valve_regurgitation1.43651646
40MP0002295_abnormal_pulmonary_circulatio1.43157314
41MP0002796_impaired_skin_barrier1.42418550
42MP0001851_eye_inflammation1.41998621
43MP0004185_abnormal_adipocyte_glucose1.39993180
44MP0004510_myositis1.39780850
45MP0000749_muscle_degeneration1.38346512
46MP0000762_abnormal_tongue_morphology1.37182231
47MP0003634_abnormal_glial_cell1.34476483
48MP0000462_abnormal_digestive_system1.33620319
49MP0004134_abnormal_chest_morphology1.33293597
50MP0001849_ear_inflammation1.32908618
51MP0000647_abnormal_sebaceous_gland1.32587597
52MP0002877_abnormal_melanocyte_morpholog1.29564189
53MP0001346_abnormal_lacrimal_gland1.23949069
54MP0006054_spinal_hemorrhage1.21452621
55MP0000343_altered_response_to1.21237730
56MP0008004_abnormal_stomach_pH1.20892495
57MP0001533_abnormal_skeleton_physiology1.20229957
58MP0005166_decreased_susceptibility_to1.19683997
59MP0003806_abnormal_nucleotide_metabolis1.19635889
60MP0000372_irregular_coat_pigmentation1.15235092
61MP0002452_abnormal_antigen_presenting1.14229999
62MP0003329_amyloid_beta_deposits1.13553400
63MP0001845_abnormal_inflammatory_respons1.13268927
64MP0003183_abnormal_peptide_metabolism1.13173473
65MP0004742_abnormal_vestibular_system1.13032100
66MP0005503_abnormal_tendon_morphology1.12205743
67MP0003191_abnormal_cellular_cholesterol1.12046496
68MP0002419_abnormal_innate_immunity1.11240145
69MP0006082_CNS_inflammation1.10900256
70MP0003279_aneurysm1.10779306
71MP0005408_hypopigmentation1.10457370
72MP0005165_increased_susceptibility_to1.09445144
73MP0009764_decreased_sensitivity_to1.09079254
74MP0003448_altered_tumor_morphology1.08538283
75MP0008469_abnormal_protein_level1.07810055
76MP0000613_abnormal_salivary_gland1.07385053
77MP0002723_abnormal_immune_serum1.07326248
78MP0009333_abnormal_splenocyte_physiolog1.07009346
79MP0002998_abnormal_bone_remodeling1.06726697
80MP0009785_altered_susceptibility_to1.06636256
81MP0004264_abnormal_extraembryonic_tissu1.05896274
82MP0005257_abnormal_intraocular_pressure1.04331822
83MP0002060_abnormal_skin_morphology1.04132523
84MP0002148_abnormal_hypersensitivity_rea1.02928605
85MP0005085_abnormal_gallbladder_physiolo1.01391447
86MP0000249_abnormal_blood_vessel1.01123268
87MP0005164_abnormal_response_to1.00782309
88MP0001666_abnormal_nutrient_absorption1.00336596
89MP0001661_extended_life_span0.99932323
90MP0001545_abnormal_hematopoietic_system0.99693351
91MP0005397_hematopoietic_system_phenotyp0.99693351
92MP0001800_abnormal_humoral_immune0.97997420
93MP0001542_abnormal_bone_strength0.97354989
94MP0002098_abnormal_vibrissa_morphology0.95765944
95MP0000467_abnormal_esophagus_morphology0.95737309
96MP0001819_abnormal_immune_cell0.94826601
97MP0002420_abnormal_adaptive_immunity0.94778464
98MP0004885_abnormal_endolymph0.94636654
99MP0010329_abnormal_lipoprotein_level0.94554255
100MP0010352_gastrointestinal_tract_polyps0.94388691
101MP0004883_abnormal_blood_vessel0.93959034
102MP0009250_abnormal_appendicular_skeleto0.93596522
103MP0005501_abnormal_skin_physiology0.92705559
104MP0005666_abnormal_adipose_tissue0.91221346
105MP0004147_increased_porphyrin_level0.89480144
106MP0002405_respiratory_system_inflammati0.88769978
107MP0005025_abnormal_response_to0.87547137
108MP0005623_abnormal_meninges_morphology0.87364123
109MP0003075_altered_response_to0.87072044
110MP0000377_abnormal_hair_follicle0.86593922
111MP0003045_fibrosis0.86567875
112MP0004142_abnormal_muscle_tone0.86199836
113MP0005167_abnormal_blood-brain_barrier0.85873923
114MP0005390_skeleton_phenotype0.84669731
115MP0005375_adipose_tissue_phenotype0.84151124
116MP0003011_delayed_dark_adaptation0.83582593
117MP0005671_abnormal_response_to0.83465385
118MP0005381_digestive/alimentary_phenotyp0.83281202
119MP0002971_abnormal_brown_adipose0.82931065
120MP0004019_abnormal_vitamin_homeostasis0.82466713
121MP0005670_abnormal_white_adipose0.82234468
122MP0003656_abnormal_erythrocyte_physiolo0.82154062
123MP0001299_abnormal_eye_distance/0.80928355
124MP0002009_preneoplasia0.80268311
125MP0005083_abnormal_biliary_tract0.79951386
126MP0002118_abnormal_lipid_homeostasis0.78617007
127MP0002254_reproductive_system_inflammat0.78616370
128MP0000747_muscle_weakness0.78448628
129MP0009643_abnormal_urine_homeostasis0.78258613
130MP0003091_abnormal_cell_migration0.78120816
131MP0001853_heart_inflammation0.78106495
132MP0005508_abnormal_skeleton_morphology0.77457152
133MP0001905_abnormal_dopamine_level0.77413574
134MP0002133_abnormal_respiratory_system0.76490087
135MP0005388_respiratory_system_phenotype0.76490087
136MP0000604_amyloidosis0.76268537
137MP0000733_abnormal_muscle_development0.76227121
138MP0005595_abnormal_vascular_smooth0.75806917
139MP0005023_abnormal_wound_healing0.75492029
140MP0003186_abnormal_redox_activity0.75393013
141MP0000685_abnormal_immune_system0.74075247
142MP0000751_myopathy0.71198727
143MP0003632_abnormal_nervous_system0.71060141
144MP0003566_abnormal_cell_adhesion0.70774496
145MP0001216_abnormal_epidermal_layer0.69286205
146MP0010368_abnormal_lymphatic_system0.69258474
147MP0010771_integument_phenotype0.69121295
148MP0001790_abnormal_immune_system0.69066094
149MP0005387_immune_system_phenotype0.69066094
150MP0003828_pulmonary_edema0.69023918
151MP0005000_abnormal_immune_tolerance0.68871475

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)4.51940056
2Neurofibrillary tangles (HP:0002185)4.45867916
3Systemic lupus erythematosus (HP:0002725)3.63152226
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.55154061
5Eczematoid dermatitis (HP:0000976)3.40022334
6Peripheral hypomyelination (HP:0007182)3.37400876
7Muscle fiber splitting (HP:0003555)3.21600033
8Nonprogressive disorder (HP:0003680)3.15245397
9Premature rupture of membranes (HP:0001788)3.12153556
10Sensory axonal neuropathy (HP:0003390)3.06106298
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.02296731
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.02296731
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.99205041
14Onion bulb formation (HP:0003383)2.93464767
15Congenital ichthyosiform erythroderma (HP:0007431)2.92409162
16Purpura (HP:0000979)2.91122523
17Abnormality of the phalanges of the 2nd finger (HP:0009541)2.86534917
18Axonal loss (HP:0003447)2.86395824
19Vacuolated lymphocytes (HP:0001922)2.85338182
20Premature skin wrinkling (HP:0100678)2.78981611
21Myocardial infarction (HP:0001658)2.73241447
22Segmental peripheral demyelination/remyelination (HP:0003481)2.70871630
23Vertebral compression fractures (HP:0002953)2.66343348
24Slow saccadic eye movements (HP:0000514)2.52882113
25Xanthomatosis (HP:0000991)2.52615358
26Recurrent gram-negative bacterial infections (HP:0005420)2.52286321
27Protrusio acetabuli (HP:0003179)2.51936516
28Urinary glycosaminoglycan excretion (HP:0003541)2.51529706
29Mucopolysacchariduria (HP:0008155)2.51529706
30Recurrent abscess formation (HP:0002722)2.51496054
31Cerebral inclusion bodies (HP:0100314)2.51039928
32Abnormality of polysaccharide metabolism (HP:0011012)2.49604502
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49604502
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49604502
35Complement deficiency (HP:0004431)2.48020818
36Abnormality of complement system (HP:0005339)2.47309613
37Petechiae (HP:0000967)2.46630939
38Milia (HP:0001056)2.46555882
39Prolonged bleeding time (HP:0003010)2.45659837
40Deep venous thrombosis (HP:0002625)2.45362262
41Amyloidosis (HP:0011034)2.45335623
42Gingival bleeding (HP:0000225)2.44954587
43Recurrent bacterial skin infections (HP:0005406)2.42240438
44Hypoplasia of the iris (HP:0007676)2.41771337
45Stridor (HP:0010307)2.40442778
46Atrophic scars (HP:0001075)2.39648865
47Malnutrition (HP:0004395)2.36867468
48Glomerulonephritis (HP:0000099)2.36548371
49Patchy hypopigmentation of hair (HP:0011365)2.35041384
50Epistaxis (HP:0000421)2.33395669
51Polycythemia (HP:0001901)2.30973355
52Menorrhagia (HP:0000132)2.29167603
53Distal lower limb muscle weakness (HP:0009053)2.28905065
54Hepatosplenomegaly (HP:0001433)2.27119660
55Gingivitis (HP:0000230)2.24838923
56Hemorrhage of the eye (HP:0011885)2.24552419
57White forelock (HP:0002211)2.23809249
58Alacrima (HP:0000522)2.22698331
59Aplasia involving bones of the upper limbs (HP:0009823)2.21025799
60Aplasia of the phalanges of the hand (HP:0009802)2.21025799
61Aplasia involving bones of the extremities (HP:0009825)2.21025799
62Plantar hyperkeratosis (HP:0007556)2.20239036
63Synostosis involving the elbow (HP:0003938)2.19910979
64Humeroradial synostosis (HP:0003041)2.19910979
65Spastic paraparesis (HP:0002313)2.18813350
66Spontaneous hematomas (HP:0007420)2.18411489
67Prolonged neonatal jaundice (HP:0006579)2.17847676
68Reduced antithrombin III activity (HP:0001976)2.17550686
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.17442989
70Ileus (HP:0002595)2.17105776
71Retinal dysplasia (HP:0007973)2.16927560
72Metabolic alkalosis (HP:0200114)2.15509823
73Alopecia of scalp (HP:0002293)2.13937770
74Myositis (HP:0100614)2.12738752
75Gowers sign (HP:0003391)2.12579725
76Orchitis (HP:0100796)2.12124979
77Increased connective tissue (HP:0009025)2.11128503
78Hyporeflexia of lower limbs (HP:0002600)2.09628678
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.09292320
80Abnormality of the 2nd finger (HP:0004100)2.08672339
81Abnormality of macrophages (HP:0004311)2.08598003
82Split foot (HP:0001839)2.07944857
83Abnormality of nail color (HP:0100643)2.07861180
84Abnormality of the middle phalanges of the toes (HP:0010183)2.06698102
85Increased serum ferritin (HP:0003281)2.06219101
86Distal lower limb amyotrophy (HP:0008944)2.05671257
87Pterygium (HP:0001059)2.05406602
88Cervical subluxation (HP:0003308)2.04943998
89Abnormal platelet volume (HP:0011876)2.04025934
90Abnormal blistering of the skin (HP:0008066)2.02635941
91Asymmetric septal hypertrophy (HP:0001670)2.02110602
92Barrel-shaped chest (HP:0001552)2.01164484
93Abnormal hemoglobin (HP:0011902)2.01057349
94Type I transferrin isoform profile (HP:0003642)1.99071359
95Increased mean platelet volume (HP:0011877)1.98816872
96Hypertriglyceridemia (HP:0002155)1.98453765
97Broad metatarsal (HP:0001783)1.98051422
98Fragile skin (HP:0001030)1.97815076
99Pulmonary artery stenosis (HP:0004415)1.97439350
100Dysostosis multiplex (HP:0000943)1.97294574
101Epiphyseal dysplasia (HP:0002656)1.96688294
102Anhidrosis (HP:0000970)1.94555124
103Pustule (HP:0200039)1.94312447
104Renal Fanconi syndrome (HP:0001994)1.94149541
105Increased IgE level (HP:0003212)1.94067497
106Abnormal auditory evoked potentials (HP:0006958)1.92360377
107Progressive neurologic deterioration (HP:0002344)1.91147695
108Thin bony cortex (HP:0002753)1.89476630
109Flat acetabular roof (HP:0003180)1.88842342
110Conical tooth (HP:0000698)1.88188654
111Cerebral aneurysm (HP:0004944)1.87000013
112Peritonitis (HP:0002586)1.85310050
113Abnormality of secondary sexual hair (HP:0009888)1.84213788
114Abnormality of the axillary hair (HP:0100134)1.84213788
115Vascular calcification (HP:0004934)1.83988889
116Nephritis (HP:0000123)1.82603007
117Onycholysis (HP:0001806)1.82522116
118Aortic aneurysm (HP:0004942)1.82252442
119Right ventricular cardiomyopathy (HP:0011663)1.81466574
120Amelogenesis imperfecta (HP:0000705)1.81445950
121Infantile muscular hypotonia (HP:0008947)1.81378893
122Abdominal distention (HP:0003270)1.81150496
123Impaired platelet aggregation (HP:0003540)1.80822615
124Abnormal platelet function (HP:0011869)1.80822615
125Osteolytic defects of the hand bones (HP:0009699)1.79723390
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.79723390
127Cardiovascular calcification (HP:0011915)1.79472146
128Abnormality of iron homeostasis (HP:0011031)1.79405669
129Vascular tortuosity (HP:0004948)1.79282628
130Mitral stenosis (HP:0001718)1.78722183
131Abnormality of the Achilles tendon (HP:0005109)1.78504069
132Cerebral hypomyelination (HP:0006808)1.78177879
133Abnormality of the common coagulation pathway (HP:0010990)1.77480402
134Joint hemorrhage (HP:0005261)1.76906699
135Aortic dissection (HP:0002647)1.76123074
136Corneal erosion (HP:0200020)1.76102014
137Bone pain (HP:0002653)1.75680081
138Arterial tortuosity (HP:0005116)1.75275461
139Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75216940
140Increased cerebral lipofuscin (HP:0011813)1.74420970
141Nasolacrimal duct obstruction (HP:0000579)1.73730821
142Polygenic inheritance (HP:0010982)1.72236657
143Hypoplastic ischia (HP:0003175)1.72035741
144Abnormality of liposaccharide metabolism (HP:0010968)1.71904417
145Abnormality of glycosphingolipid metabolism (HP:0004343)1.71904417
146Abnormality of glycolipid metabolism (HP:0010969)1.71904417
147Autoamputation (HP:0001218)1.71841839
148Interstitial pulmonary disease (HP:0006530)1.71573184
149Partial duplication of thumb phalanx (HP:0009944)1.71495964
150Clumsiness (HP:0002312)1.71212064
151Ectropion (HP:0000656)1.71158548
152Respiratory distress (HP:0002098)1.71137938
153Nail dystrophy (HP:0008404)1.70672855
154Abnormality of glutamine family amino acid metabolism (HP:0010902)1.70403756
155Weak cry (HP:0001612)1.69897833
156Palmoplantar hyperkeratosis (HP:0000972)1.69804317
157Paraparesis (HP:0002385)1.69753288
158Cellulitis (HP:0100658)1.69732994
159Nemaline bodies (HP:0003798)1.69700932
160Thick nail (HP:0001805)1.68933992
161Urticaria (HP:0001025)1.68361942
162Loss of speech (HP:0002371)1.68095207
163Dilatation of the ascending aorta (HP:0005111)1.66924117
164Increased variability in muscle fiber diameter (HP:0003557)1.66921204
165Achilles tendon contracture (HP:0001771)1.66705829
166Muscle fiber inclusion bodies (HP:0100299)1.65765572
167Hypoplastic pelvis (HP:0008839)1.65539793
168Short hallux (HP:0010109)1.65198459
169Fragile nails (HP:0001808)1.64045932
170Episodic fever (HP:0001954)1.63695990
171Decreased lacrimation (HP:0000633)1.63451772
172Abnormal protein glycosylation (HP:0012346)1.63341238
173Abnormal glycosylation (HP:0012345)1.63341238
174Abnormal protein N-linked glycosylation (HP:0012347)1.63341238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.32978337
2EPHB13.97531699
3TNIK3.00092715
4MUSK2.98148897
5MAPKAPK52.69465549
6RIPK12.69289945
7MST42.65382893
8OXSR12.63575546
9MET2.32819197
10MAP3K32.26474880
11PBK2.22036449
12NLK2.20341814
13PRKD22.00955643
14MAP2K31.98138511
15RIPK41.97195975
16TRIB31.94488540
17PKN11.81824365
18ZAP701.77311213
19TYK21.76315931
20SIK11.69262033
21LMTK21.61052203
22CLK11.60614835
23TAOK21.54579411
24TRPM71.54493393
25CDK191.52519311
26CASK1.49741089
27FGFR41.49501218
28MAPK151.46262499
29EIF2AK31.42986328
30PDGFRA1.41982847
31MAP3K11.41960897
32IRAK31.39509573
33MAP3K111.38482744
34TIE11.38050560
35WNK41.34987222
36NME21.31054210
37MAP3K131.25797633
38TESK11.25382447
39CDC42BPA1.24762707
40JAK31.24408704
41ARAF1.22850447
42TESK21.22134131
43FGR1.21676012
44MAP3K21.21075668
45TGFBR21.19863807
46MAP4K11.19184102
47EPHA21.18558825
48CSNK1G11.15962548
49TAOK11.15709984
50ICK1.15500614
51PAK41.15259407
52KSR21.13717621
53IRAK11.13581280
54MAP2K21.11801594
55CAMK2D1.11582456
56MST1R1.11068832
57PRKD11.08666685
58JAK11.06264132
59BCR1.05409562
60CAMK2B1.04976371
61MAP3K61.04969978
62LIMK11.02135341
63FGFR21.01563172
64PRKG21.01291167
65MATK1.00334556
66KIT0.98713993
67PIK3CA0.98537263
68CSNK1A1L0.98138447
69PIM20.97751547
70PIK3CG0.97743877
71BLK0.96282828
72DDR20.96040785
73EPHA30.95994622
74WNK10.95190420
75IRAK40.95065480
76PDPK10.94999672
77PTK20.92435781
78ROCK20.92083627
79PTK60.89839402
80TLK10.88678298
81NEK60.88515989
82NEK90.84164263
83CSNK1G30.84029096
84FGFR30.82037640
85HIPK20.81192090
86OBSCN0.78206959
87MAPKAPK30.77135551
88PDGFRB0.75682915
89IRAK20.75669294
90CAMK2G0.75125189
91GRK60.74656883
92DMPK0.74175639
93FES0.73711166
94MYLK0.72955379
95IKBKB0.72539694
96JAK20.70291383
97SMG10.69907273
98CSK0.69775699
99TBK10.68673619
100HCK0.68319915
101UHMK10.66453026
102MOS0.66418209
103BTK0.64165252
104STK240.63498900
105GSK3A0.63374205
106TAOK30.63128456
107CAMKK20.62651918
108BMPR1B0.61940579
109TTN0.61621764
110LATS20.61336557
111SGK2230.58842613
112SGK4940.58842613
113NUAK10.58748653
114ERBB40.58646929
115PDK10.58588262
116RPS6KA20.57390089
117RET0.57137070
118PHKG20.56840097
119PHKG10.56840097
120MKNK20.55620859
121SYK0.55470928
122IKBKE0.54074841
123GRK70.53388486
124PRKCE0.51977965
125MAP3K140.51872261
126NTRK10.51789889
127PAK20.51699986
128MAPK120.51508338
129MARK20.51138134
130ABL10.50886174
131TEC0.50616452
132ABL20.50587921
133ERN10.49979467
134RPS6KA50.49721566
135BMPR20.49273098
136STK380.48907867
137CSF1R0.48551181
138MAP3K50.48455663
139MAPK110.48349160
140PRPF4B0.47562940
141DYRK20.47445363
142PRKAA20.47282662
143EIF2AK20.46965561
144STK100.46960069
145PTK2B0.46143479
146SGK30.45823314
147LCK0.44542784
148LYN0.43631182
149FER0.43619728
150MAP2K60.43463753
151EPHB20.41684866
152LRRK20.41535803
153PKN20.41352394
154MAPK70.41269129
155BMX0.40840437
156KDR0.40750289
157MAPKAPK20.40457619
158GRK10.40166136
159LATS10.39822744
160CAMK2A0.39754443
161ROCK10.39433788

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.11617660
2Steroid biosynthesis_Homo sapiens_hsa001003.81925694
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.65936796
4Ether lipid metabolism_Homo sapiens_hsa005652.94610350
5Sphingolipid metabolism_Homo sapiens_hsa006002.76722419
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.58014622
7Protein export_Homo sapiens_hsa030602.30873097
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29252498
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18481079
10Histidine metabolism_Homo sapiens_hsa003402.02410610
11Other glycan degradation_Homo sapiens_hsa005111.98325603
12Sulfur metabolism_Homo sapiens_hsa009201.97367134
13Malaria_Homo sapiens_hsa051441.85620933
14Linoleic acid metabolism_Homo sapiens_hsa005911.83368153
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82176216
16ECM-receptor interaction_Homo sapiens_hsa045121.81902306
17Osteoclast differentiation_Homo sapiens_hsa043801.75248294
18Arachidonic acid metabolism_Homo sapiens_hsa005901.67001785
19Lysosome_Homo sapiens_hsa041421.59949304
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56936368
21Folate biosynthesis_Homo sapiens_hsa007901.55004589
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39274048
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37923074
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36599593
25Vitamin digestion and absorption_Homo sapiens_hsa049771.34355093
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34292636
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34241526
28Tuberculosis_Homo sapiens_hsa051521.29789588
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26545666
30Mineral absorption_Homo sapiens_hsa049781.24938694
31TNF signaling pathway_Homo sapiens_hsa046681.21785768
32Galactose metabolism_Homo sapiens_hsa000521.20982047
33Glutathione metabolism_Homo sapiens_hsa004801.14515970
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14067523
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11692352
36Arginine and proline metabolism_Homo sapiens_hsa003301.08499441
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07925149
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06330027
39Prion diseases_Homo sapiens_hsa050201.06163352
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05694138
41Acute myeloid leukemia_Homo sapiens_hsa052211.04747688
42Fructose and mannose metabolism_Homo sapiens_hsa000511.03384408
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02261591
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02042070
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.01754128
46Bladder cancer_Homo sapiens_hsa052191.00792782
47Adipocytokine signaling pathway_Homo sapiens_hsa049201.00320582
48Allograft rejection_Homo sapiens_hsa053300.99909597
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.99716077
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98930570
51Fatty acid metabolism_Homo sapiens_hsa012120.97714058
52Vitamin B6 metabolism_Homo sapiens_hsa007500.96474941
53Platelet activation_Homo sapiens_hsa046110.95996861
54Chemical carcinogenesis_Homo sapiens_hsa052040.94279331
55Caffeine metabolism_Homo sapiens_hsa002320.93255455
56Influenza A_Homo sapiens_hsa051640.92452908
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.91868755
58B cell receptor signaling pathway_Homo sapiens_hsa046620.91340721
59Rheumatoid arthritis_Homo sapiens_hsa053230.91212215
60Protein digestion and absorption_Homo sapiens_hsa049740.90098598
61Fatty acid biosynthesis_Homo sapiens_hsa000610.87913227
62Starch and sucrose metabolism_Homo sapiens_hsa005000.85394655
63Legionellosis_Homo sapiens_hsa051340.81816340
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.81216538
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81119619
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80764074
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80294996
68Chronic myeloid leukemia_Homo sapiens_hsa052200.79990281
69Retinol metabolism_Homo sapiens_hsa008300.79251500
70Chemokine signaling pathway_Homo sapiens_hsa040620.78812370
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78491104
72Tight junction_Homo sapiens_hsa045300.78238812
73Pertussis_Homo sapiens_hsa051330.78020684
74Viral myocarditis_Homo sapiens_hsa054160.77972295
75Oxidative phosphorylation_Homo sapiens_hsa001900.76244625
76VEGF signaling pathway_Homo sapiens_hsa043700.76164237
77Fat digestion and absorption_Homo sapiens_hsa049750.76147408
78Pancreatic cancer_Homo sapiens_hsa052120.75906395
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75496324
80Apoptosis_Homo sapiens_hsa042100.74197152
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73918336
82Nitrogen metabolism_Homo sapiens_hsa009100.73001911
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.72987091
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72686206
85Insulin resistance_Homo sapiens_hsa049310.72624698
86Focal adhesion_Homo sapiens_hsa045100.71482469
87Phagosome_Homo sapiens_hsa041450.71449905
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71441398
89PPAR signaling pathway_Homo sapiens_hsa033200.71438549
90Peroxisome_Homo sapiens_hsa041460.71374342
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71073755
92African trypanosomiasis_Homo sapiens_hsa051430.69734994
93Amoebiasis_Homo sapiens_hsa051460.69056204
94Arginine biosynthesis_Homo sapiens_hsa002200.68702632
95Phenylalanine metabolism_Homo sapiens_hsa003600.68121022
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66953285
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64933920
98Proteoglycans in cancer_Homo sapiens_hsa052050.64843287
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.64562565
100Ovarian steroidogenesis_Homo sapiens_hsa049130.64014937
101Small cell lung cancer_Homo sapiens_hsa052220.63593833
102Bile secretion_Homo sapiens_hsa049760.63236837
103Antigen processing and presentation_Homo sapiens_hsa046120.63149338
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60929636
105ABC transporters_Homo sapiens_hsa020100.60421105
106Staphylococcus aureus infection_Homo sapiens_hsa051500.59266740
107Measles_Homo sapiens_hsa051620.59094354
108Autoimmune thyroid disease_Homo sapiens_hsa053200.57833759
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57484118
110Hematopoietic cell lineage_Homo sapiens_hsa046400.56963162
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56699210
112Pentose phosphate pathway_Homo sapiens_hsa000300.56479363
113Asthma_Homo sapiens_hsa053100.56050772
114Axon guidance_Homo sapiens_hsa043600.55689451
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55376390
116Vibrio cholerae infection_Homo sapiens_hsa051100.54837859
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.54636276
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.54541373
119Non-small cell lung cancer_Homo sapiens_hsa052230.54340760
120Salmonella infection_Homo sapiens_hsa051320.54169231
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.53995697
122Graft-versus-host disease_Homo sapiens_hsa053320.53250529
123GnRH signaling pathway_Homo sapiens_hsa049120.52881420
124Fatty acid degradation_Homo sapiens_hsa000710.52813779
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.52688979
126Insulin signaling pathway_Homo sapiens_hsa049100.51731969
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.51330403
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50946505
129Propanoate metabolism_Homo sapiens_hsa006400.50241050
130Glycerolipid metabolism_Homo sapiens_hsa005610.49612001
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.48400661
132beta-Alanine metabolism_Homo sapiens_hsa004100.48244796
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47657353
134Hepatitis B_Homo sapiens_hsa051610.47398648
135Metabolic pathways_Homo sapiens_hsa011000.47255806
136Hepatitis C_Homo sapiens_hsa051600.47069694
137Renal cell carcinoma_Homo sapiens_hsa052110.46689830
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.46515343
139Type I diabetes mellitus_Homo sapiens_hsa049400.46203056
140Pancreatic secretion_Homo sapiens_hsa049720.45347357
141Leishmaniasis_Homo sapiens_hsa051400.42697986
142Endocytosis_Homo sapiens_hsa041440.42668383
143Sulfur relay system_Homo sapiens_hsa041220.42152548
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41545066
145Toxoplasmosis_Homo sapiens_hsa051450.41197224
146Regulation of autophagy_Homo sapiens_hsa041400.39654297
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37446308
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35943756
149Prostate cancer_Homo sapiens_hsa052150.35094037
150Complement and coagulation cascades_Homo sapiens_hsa046100.34709802
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34582811
152Alzheimers disease_Homo sapiens_hsa050100.34030604
153Shigellosis_Homo sapiens_hsa051310.33844141
154Renin-angiotensin system_Homo sapiens_hsa046140.33732083
155Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33635573

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