TM6SF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.35101134
2neutrophil activation involved in immune response (GO:0002283)5.57580842
3regulation of B cell receptor signaling pathway (GO:0050855)5.57057934
4respiratory burst (GO:0045730)4.75958784
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.71223619
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.71223619
7modulation by symbiont of host immune response (GO:0052553)4.71223619
8positive regulation by symbiont of host defense response (GO:0052509)4.71223619
9modulation by symbiont of host defense response (GO:0052031)4.71223619
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.71223619
11regulation of interferon-beta biosynthetic process (GO:0045357)4.51101703
12neutrophil mediated immunity (GO:0002446)4.44013331
13immunoglobulin mediated immune response (GO:0016064)4.43952034
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.43335040
15positive regulation of gamma-delta T cell activation (GO:0046645)4.34998886
16neutrophil activation (GO:0042119)4.27855121
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.20440676
18leukocyte migration involved in inflammatory response (GO:0002523)4.16821425
19macrophage activation involved in immune response (GO:0002281)4.15155203
20B cell receptor signaling pathway (GO:0050853)4.11954368
21negative regulation of phagocytosis (GO:0050765)4.08482886
22response to peptidoglycan (GO:0032494)4.06618156
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.03625317
24negative regulation of cell killing (GO:0031342)4.03625317
25positive regulation of B cell differentiation (GO:0045579)4.03521608
26granulocyte activation (GO:0036230)4.03000161
27regulation of platelet aggregation (GO:0090330)3.89251467
28cellular extravasation (GO:0045123)3.88666699
29regulation of B cell differentiation (GO:0045577)3.86152385
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.84832115
31myeloid cell activation involved in immune response (GO:0002275)3.83418328
32regulation of platelet activation (GO:0010543)3.81867232
33positive regulation of antigen processing and presentation (GO:0002579)3.74936791
34antigen processing and presentation of endogenous antigen (GO:0019883)3.73509715
35pinocytosis (GO:0006907)3.72445132
36regulation of mast cell activation (GO:0033003)3.70273589
37regulation of mast cell degranulation (GO:0043304)3.70164113
38detection of molecule of bacterial origin (GO:0032490)3.66418098
39positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.61688198
40mast cell activation (GO:0045576)3.61339298
41cellular response to zinc ion (GO:0071294)3.59509594
42Arp2/3 complex-mediated actin nucleation (GO:0034314)3.54851418
43production of molecular mediator involved in inflammatory response (GO:0002532)3.53090608
44positive regulation of mast cell activation (GO:0033005)3.50271418
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49576365
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49576365
47detection of other organism (GO:0098543)3.46245440
48regulation of mast cell activation involved in immune response (GO:0033006)3.45914237
49myeloid leukocyte mediated immunity (GO:0002444)3.45349165
50positive regulation of interferon-alpha production (GO:0032727)3.43843827
51response to muramyl dipeptide (GO:0032495)3.39038753
52leukocyte aggregation (GO:0070486)3.38927916
53defense response to protozoan (GO:0042832)3.36032918
54leukocyte mediated cytotoxicity (GO:0001909)3.34438671
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.31484181
56adenosine receptor signaling pathway (GO:0001973)3.31226058
57microglial cell activation (GO:0001774)3.31088486
58superoxide anion generation (GO:0042554)3.30698825
59response to fungus (GO:0009620)3.29524862
60B cell mediated immunity (GO:0019724)3.27851919
61myeloid dendritic cell activation (GO:0001773)3.27625419
62positive regulation of mast cell activation involved in immune response (GO:0033008)3.26978163
63positive regulation of mast cell degranulation (GO:0043306)3.26978163
64regulation of antigen processing and presentation (GO:0002577)3.25779639
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25505433
66response to host immune response (GO:0052572)3.25505433
67thrombin receptor signaling pathway (GO:0070493)3.24387718
68regulation of interferon-alpha production (GO:0032647)3.23779967
69macrophage activation (GO:0042116)3.21748223
70negative regulation of granulocyte differentiation (GO:0030853)3.21337157
71sarcoplasmic reticulum calcium ion transport (GO:0070296)3.21017576
72germinal center formation (GO:0002467)3.19640008
73detection of external biotic stimulus (GO:0098581)3.18614050
74negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.15698960
75negative regulation of T-helper cell differentiation (GO:0045623)3.15698960
76negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.15499885
77response to protozoan (GO:0001562)3.14716296
78T cell migration (GO:0072678)3.12530473
79protein neddylation (GO:0045116)3.12292760
80negative regulation of interleukin-17 production (GO:0032700)3.11758901
81myeloid leukocyte activation (GO:0002274)3.10514937
82positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.10485696
83reactive oxygen species biosynthetic process (GO:1903409)3.10117176
84regulation of T-helper 2 cell differentiation (GO:0045628)3.07226218
85regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07173642
86detection of bacterium (GO:0016045)3.05909174
87interferon-gamma-mediated signaling pathway (GO:0060333)2.97266534
88interferon-gamma production (GO:0032609)2.94735221
89dendritic cell migration (GO:0036336)2.93838073
90positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93578049
91response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93436212
92response to host (GO:0075136)2.93436212
93response to host defenses (GO:0052200)2.93436212
94leukocyte degranulation (GO:0043299)2.92959010
95regulation of leukocyte degranulation (GO:0043300)2.91250821
96leukotriene metabolic process (GO:0006691)2.90285318
97negative regulation of interleukin-12 production (GO:0032695)2.89620601
98negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.89470066
99lipopolysaccharide-mediated signaling pathway (GO:0031663)2.89222097
100negative regulation of mast cell activation (GO:0033004)2.88718386
101B cell homeostasis (GO:0001782)2.86211313
102B cell proliferation (GO:0042100)2.85596942
103positive regulation of macrophage differentiation (GO:0045651)2.84863656
104dendritic cell chemotaxis (GO:0002407)2.84395483
105negative regulation of growth of symbiont in host (GO:0044130)2.83775111
106negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.83775111
107modulation of growth of symbiont involved in interaction with host (GO:0044144)2.83775111
108regulation of growth of symbiont in host (GO:0044126)2.83775111
109positive regulation of monocyte chemotaxis (GO:0090026)2.83461183
110G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.82781016
111positive regulation of toll-like receptor signaling pathway (GO:0034123)2.81617868
112positive regulation of cellular amide metabolic process (GO:0034250)2.80285800
113regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.80019544
114cellular response to exogenous dsRNA (GO:0071360)2.79467065
115cellular response to interferon-beta (GO:0035458)2.78404266
116regulation of gamma-delta T cell activation (GO:0046643)2.75724582
117negative regulation of B cell proliferation (GO:0030889)2.75595384
118cellular response to thyroid hormone stimulus (GO:0097067)2.74661539
119myeloid dendritic cell differentiation (GO:0043011)2.74014307
120actin nucleation (GO:0045010)2.72866450
121detection of biotic stimulus (GO:0009595)2.72043413
122phagocytosis, engulfment (GO:0006911)2.71900263
123cytidine metabolic process (GO:0046087)2.68562151
124cytidine catabolic process (GO:0006216)2.68562151
125cytidine deamination (GO:0009972)2.68562151
126neutrophil chemotaxis (GO:0030593)2.68339105
127negative regulation of homotypic cell-cell adhesion (GO:0034111)2.67701770
128regulation of MHC class II biosynthetic process (GO:0045346)2.67428260
129regulation of interleukin-17 production (GO:0032660)2.65841497
130negative regulation of platelet activation (GO:0010544)2.65833027
131regulation of regulatory T cell differentiation (GO:0045589)2.64877533
132G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.64674516
133regulation of gamma-delta T cell differentiation (GO:0045586)2.63978709
134lipoxygenase pathway (GO:0019372)2.61547765
135neutrophil migration (GO:1990266)2.61202706
136positive regulation of leukocyte degranulation (GO:0043302)2.59244656
137positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.57949067
138histamine secretion (GO:0001821)2.57603944
139positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.57043162
140negative regulation of lymphocyte mediated immunity (GO:0002707)2.56133686
141regulation of T-helper 1 cell differentiation (GO:0045625)2.52733832
142positive regulation of type 2 immune response (GO:0002830)2.52011122
143purinergic nucleotide receptor signaling pathway (GO:0035590)2.51428453
144positive regulation of macrophage cytokine production (GO:0060907)2.49868151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.05030869
2* IRF8_21731497_ChIP-ChIP_J774_Mouse5.39355713
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.37445564
4E2F7_22180533_ChIP-Seq_HELA_Human4.42372167
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.07657274
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.99918108
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.91575751
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.74402634
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.71590067
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.49026373
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37454538
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.37083270
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.24457722
14SCL_19346495_ChIP-Seq_HPC-7_Human3.09081692
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.87721023
16* SPI1_23547873_ChIP-Seq_NB4_Human2.83552314
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68908231
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.67034099
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.55902499
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52964501
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.48067120
22VDR_21846776_ChIP-Seq_THP-1_Human2.45060222
23SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.44468412
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.43240310
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.39707823
26EZH2_22144423_ChIP-Seq_EOC_Human2.38677397
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.31391608
28VDR_24763502_ChIP-Seq_THP-1_Human2.28510392
29MYB_26560356_Chip-Seq_TH2_Human2.22946305
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.21404198
31* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18846403
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.12229229
33RUNX_20019798_ChIP-Seq_JUKART_Human2.10075288
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04919908
35* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.01157288
36* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.00178340
37GATA1_22025678_ChIP-Seq_K562_Human1.99397143
38SPI1_23127762_ChIP-Seq_K562_Human1.96566157
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.94919354
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87864726
41* MYB_26560356_Chip-Seq_TH1_Human1.87035472
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84186263
43MAF_26560356_Chip-Seq_TH1_Human1.81314294
44PU_27001747_Chip-Seq_BMDM_Mouse1.81058786
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75821755
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.75413665
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73540328
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71639599
49MYC_22102868_ChIP-Seq_BL_Human1.70258002
50GBX2_23144817_ChIP-Seq_PC3_Human1.69523653
51TAF15_26573619_Chip-Seq_HEK293_Human1.62567183
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60361393
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58126414
54UTX_26944678_Chip-Seq_JUKART_Human1.56533221
55GATA1_19941826_ChIP-Seq_K562_Human1.54937609
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54411009
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53554594
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.53420768
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52964646
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47604986
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45738261
62* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43485198
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43012358
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42529952
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40446021
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37432172
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36889879
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36287811
69TCF7_22412390_ChIP-Seq_EML_Mouse1.36055675
70* GATA2_19941826_ChIP-Seq_K562_Human1.34538050
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32553040
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.31417720
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30813143
74* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30358330
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28266713
76GATA3_27048872_Chip-Seq_THYMUS_Human1.26762571
77VDR_24787735_ChIP-Seq_THP-1_Human1.25854636
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23930997
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22739319
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22545685
81HTT_18923047_ChIP-ChIP_STHdh_Human1.19559806
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18940788
83GATA3_26560356_Chip-Seq_TH2_Human1.18032018
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15741501
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15106210
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14351701
87KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10012521
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09991122
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06076079
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06076079
91GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04917062
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04059440
93VDR_22108803_ChIP-Seq_LS180_Human1.02695336
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02210767
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.99318810
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95667243
97MAF_26560356_Chip-Seq_TH2_Human0.95464150
98* GATA2_21666600_ChIP-Seq_HMVEC_Human0.95391604
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.95208464
100* SMRT_27268052_Chip-Seq_Bcells_Human0.93972902
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92532911
102BCAT_22108803_ChIP-Seq_LS180_Human0.90999299
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90668913
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88274524
105ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86400895
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86370904
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86255139
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85977507
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85886309
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84768691
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84532403
112ELK1_19687146_ChIP-ChIP_HELA_Human0.83485819
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82476147
114SMAD4_21799915_ChIP-Seq_A2780_Human0.82003308
115CIITA_25753668_ChIP-Seq_RAJI_Human0.81810724
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81421995
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.80586723
118TFEB_21752829_ChIP-Seq_HELA_Human0.80177424
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79991836
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79716956
121SPI1_20517297_ChIP-Seq_HL60_Human0.79448672
122VDR_23849224_ChIP-Seq_CD4+_Human0.79437386
123* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78972632
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76998119
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76998119
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.75741637
127SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75715300
128FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.75583854
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75143503
130P300_19829295_ChIP-Seq_ESCs_Human0.74235338
131EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.72840663
132E2F1_21310950_ChIP-Seq_MCF-7_Human0.71374955
133GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70730442
134ETS1_22383799_ChIP-Seq_G1ME_Mouse0.68787806
135* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66727034
136KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.65373944
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.65334782
138FOXP3_21729870_ChIP-Seq_TREG_Human0.64802289
139IKZF1_21737484_ChIP-ChIP_HCT116_Human0.61184963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.67777077
2MP0003436_decreased_susceptibility_to3.54573866
3MP0002419_abnormal_innate_immunity3.21191076
4MP0002148_abnormal_hypersensitivity_rea3.19939026
5MP0003303_peritoneal_inflammation3.11405424
6MP0005000_abnormal_immune_tolerance3.08482887
7MP0009785_altered_susceptibility_to2.96271599
8MP0005671_abnormal_response_to2.90901168
9MP0001800_abnormal_humoral_immune2.86512543
10MP0002452_abnormal_antigen_presenting2.82985197
11MP0005025_abnormal_response_to2.79911479
12MP0001790_abnormal_immune_system2.65303234
13MP0005387_immune_system_phenotype2.65303234
14MP0002723_abnormal_immune_serum2.61493678
15MP0002420_abnormal_adaptive_immunity2.60494247
16MP0002396_abnormal_hematopoietic_system2.60367458
17MP0005464_abnormal_platelet_physiology2.57864647
18MP0001819_abnormal_immune_cell2.57785748
19MP0000685_abnormal_immune_system2.50426928
20MP0005174_abnormal_tail_pigmentation2.37592385
21MP0003724_increased_susceptibility_to2.35780520
22MP0005058_abnormal_lysosome_morphology2.31974803
23MP0008004_abnormal_stomach_pH2.28165073
24MP0003172_abnormal_lysosome_physiology2.25389410
25MP0006082_CNS_inflammation2.23688840
26MP0002405_respiratory_system_inflammati2.15302388
27MP0002398_abnormal_bone_marrow2.11438553
28MP0000716_abnormal_immune_system2.02024720
29MP0003183_abnormal_peptide_metabolism1.96105309
30MP0001853_heart_inflammation1.92951001
31MP0009333_abnormal_splenocyte_physiolog1.90873377
32MP0000569_abnormal_digit_pigmentation1.87866218
33MP0000689_abnormal_spleen_morphology1.86046288
34MP0002166_altered_tumor_susceptibility1.85110407
35MP0003763_abnormal_thymus_physiology1.83724272
36MP0001845_abnormal_inflammatory_respons1.80330668
37MP0000015_abnormal_ear_pigmentation1.80233228
38MP0004808_abnormal_hematopoietic_stem1.74752422
39MP0002429_abnormal_blood_cell1.70667773
40MP0001533_abnormal_skeleton_physiology1.70398075
41MP0002722_abnormal_immune_system1.67122130
42MP0000343_altered_response_to1.62732104
43MP0002006_tumorigenesis1.62456399
44MP0009278_abnormal_bone_marrow1.62157431
45MP0005397_hematopoietic_system_phenotyp1.61180038
46MP0001545_abnormal_hematopoietic_system1.61180038
47MP0003191_abnormal_cellular_cholesterol1.60338760
48MP0004510_myositis1.60125385
49MP0004130_abnormal_muscle_cell1.59964946
50MP0000465_gastrointestinal_hemorrhage1.59320627
51MP0010155_abnormal_intestine_physiology1.57379376
52MP0005075_abnormal_melanosome_morpholog1.56159408
53MP0003879_abnormal_hair_cell1.54746421
54MP0004036_abnormal_muscle_relaxation1.52343170
55MP0008469_abnormal_protein_level1.42802754
56MP0003300_gastrointestinal_ulcer1.39835085
57MP0001873_stomach_inflammation1.39770431
58MP0004084_abnormal_cardiac_muscle1.38017456
59MP0000858_altered_metastatic_potential1.35498169
60MP0003448_altered_tumor_morphology1.30187378
61MP0000490_abnormal_crypts_of1.25333928
62MP0003828_pulmonary_edema1.24520721
63MP0004947_skin_inflammation1.22461104
64MP0004484_altered_response_of1.20429122
65MP0000703_abnormal_thymus_morphology1.19744689
66MP0003075_altered_response_to1.19346712
67MP0005310_abnormal_salivary_gland1.16003160
68MP0002332_abnormal_exercise_endurance1.14274454
69MP0004145_abnormal_muscle_electrophysio1.13056408
70MP0003646_muscle_fatigue1.12728999
71MP0002095_abnormal_skin_pigmentation1.12683215
72MP0008874_decreased_physiological_sensi1.12439638
73MP0001851_eye_inflammation1.10649499
74MP0009764_decreased_sensitivity_to1.09707811
75MP0003866_abnormal_defecation1.06807467
76MP0000604_amyloidosis1.06117028
77MP0002998_abnormal_bone_remodeling1.06036296
78MP0000371_diluted_coat_color1.01085381
79MP0005166_decreased_susceptibility_to0.98547928
80MP0001986_abnormal_taste_sensitivity0.98334543
81MP0010307_abnormal_tumor_latency0.98328795
82MP0002933_joint_inflammation0.96869453
83MP0004742_abnormal_vestibular_system0.95981088
84MP0003690_abnormal_glial_cell0.94420722
85MP0005620_abnormal_muscle_contractility0.90262621
86MP0005451_abnormal_body_composition0.90217578
87MP0000920_abnormal_myelination0.88812594
88MP0005167_abnormal_blood-brain_barrier0.86817992
89MP0000230_abnormal_systemic_arterial0.86129142
90MP0000249_abnormal_blood_vessel0.83340420
91MP0002972_abnormal_cardiac_muscle0.82643234
92MP0009046_muscle_twitch0.82156354
93MP0005409_darkened_coat_color0.81900011
94MP0009765_abnormal_xenobiotic_induced0.80940562
95MP0003656_abnormal_erythrocyte_physiolo0.80284351
96MP0003045_fibrosis0.79940339
97MP0002019_abnormal_tumor_incidence0.77606577
98MP0004782_abnormal_surfactant_physiolog0.76308412
99MP0008007_abnormal_cellular_replicative0.76068372
100MP0009763_increased_sensitivity_to0.75480558
101MP0001968_abnormal_touch/_nociception0.73849756
102MP0010094_abnormal_chromosome_stability0.73709296
103MP0001663_abnormal_digestive_system0.73608723
104MP0004215_abnormal_myocardial_fiber0.73376648
105MP0002736_abnormal_nociception_after0.72528374
106MP0008057_abnormal_DNA_replication0.72217925
107MP0003880_abnormal_central_pattern0.71251074
108MP0004381_abnormal_hair_follicle0.70545057
109MP0009840_abnormal_foam_cell0.70071278
110MP0006035_abnormal_mitochondrial_morpho0.69930441
111MP0005390_skeleton_phenotype0.69818187
112MP0008569_lethality_at_weaning0.68750224
113MP0005535_abnormal_body_temperature0.68133766
114MP0003638_abnormal_response/metabolism_0.65078520
115MP0005164_abnormal_response_to0.64324768
116MP0002067_abnormal_sensory_capabilities0.64226166
117MP0003633_abnormal_nervous_system0.64178524
118MP0001970_abnormal_pain_threshold0.63782387
119MP0003693_abnormal_embryo_hatching0.63692233
120MP0002837_dystrophic_cardiac_calcinosis0.63573805
121MP0002277_abnormal_respiratory_mucosa0.62589328
122MP0002075_abnormal_coat/hair_pigmentati0.62201613
123MP0000767_abnormal_smooth_muscle0.58751577
124MP0002132_abnormal_respiratory_system0.58751514
125MP0003279_aneurysm0.57873699
126MP0000372_irregular_coat_pigmentation0.57549502
127MP0001879_abnormal_lymphatic_vessel0.57249077
128MP0003795_abnormal_bone_structure0.56613748
129MP0001915_intracranial_hemorrhage0.56459391
130MP0005076_abnormal_cell_differentiation0.56417217
131MP0004883_abnormal_blood_vessel0.55065602
132MP0001186_pigmentation_phenotype0.54523748
133MP0008260_abnormal_autophagy0.54485174
134MP0008873_increased_physiological_sensi0.53908913

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.30960855
2Recurrent bacterial skin infections (HP:0005406)6.51953941
3Eczematoid dermatitis (HP:0000976)6.12503176
4Recurrent gram-negative bacterial infections (HP:0005420)4.75222057
5Purpura (HP:0000979)4.70023383
6Elevated erythrocyte sedimentation rate (HP:0003565)4.55113533
7Myositis (HP:0100614)4.55077368
8Mediastinal lymphadenopathy (HP:0100721)4.54159069
9Obstructive lung disease (HP:0006536)4.44363324
10Chronic obstructive pulmonary disease (HP:0006510)4.44363324
11Abnormal platelet volume (HP:0011876)4.39849733
12Recurrent skin infections (HP:0001581)4.22515750
13Increased mean platelet volume (HP:0011877)4.22321995
14Menorrhagia (HP:0000132)4.20466681
15Abnormality of macrophages (HP:0004311)4.14462641
16Recurrent fungal infections (HP:0002841)4.04299221
17Meningitis (HP:0001287)3.80435932
18Recurrent viral infections (HP:0004429)3.67592323
19IgM deficiency (HP:0002850)3.63208681
20Systemic lupus erythematosus (HP:0002725)3.56902915
21Vacuolated lymphocytes (HP:0001922)3.50826823
22Gingivitis (HP:0000230)3.45321245
23Recurrent cutaneous fungal infections (HP:0011370)3.43814920
24Chronic mucocutaneous candidiasis (HP:0002728)3.43814920
25Orchitis (HP:0100796)3.32589227
26Nemaline bodies (HP:0003798)3.31774089
27Cellulitis (HP:0100658)3.27945942
28Muscle fiber inclusion bodies (HP:0100299)3.24195991
29Vasculitis (HP:0002633)3.22579106
30Optic neuritis (HP:0100653)3.18304152
31Retrobulbar optic neuritis (HP:0100654)3.18304152
32Hyperlipoproteinemia (HP:0010980)3.10865602
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.10506682
34Abnormality of glycolipid metabolism (HP:0010969)3.09713256
35Abnormality of liposaccharide metabolism (HP:0010968)3.09713256
36Abnormality of glycosphingolipid metabolism (HP:0004343)3.09713256
37Thrombocytosis (HP:0001894)3.06367415
38Abnormality of the vasculature of the conjunctiva (HP:0008054)3.06330089
39Agnosia (HP:0010524)3.05630907
40Abnormality of the prostate (HP:0008775)3.04906177
41Muscle fiber splitting (HP:0003555)3.01549733
42Increased cerebral lipofuscin (HP:0011813)3.00151837
43Stomatitis (HP:0010280)2.95050118
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.94381704
45Prostate neoplasm (HP:0100787)2.91362348
46Spontaneous hematomas (HP:0007420)2.88718675
47Inflammation of the large intestine (HP:0002037)2.88659330
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.87816201
49Periodontitis (HP:0000704)2.84609086
50Conjunctival telangiectasia (HP:0000524)2.82940199
51Autoimmune thrombocytopenia (HP:0001973)2.81632162
52Colitis (HP:0002583)2.78527386
53Prolonged bleeding time (HP:0003010)2.78378105
54Gastrointestinal inflammation (HP:0004386)2.77932616
55Pustule (HP:0200039)2.75798380
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.74950690
57Dysostosis multiplex (HP:0000943)2.74611383
58Disinhibition (HP:0000734)2.74288895
59Chronic otitis media (HP:0000389)2.73048022
60Petechiae (HP:0000967)2.72328270
61Panhypogammaglobulinemia (HP:0003139)2.71795675
62Atonic seizures (HP:0010819)2.70639648
63Osteomyelitis (HP:0002754)2.67822818
64Recurrent pneumonia (HP:0006532)2.61440411
65Hematochezia (HP:0002573)2.60485746
66Basal ganglia calcification (HP:0002135)2.60112432
67Agammaglobulinemia (HP:0004432)2.56129115
68Glomerulonephritis (HP:0000099)2.54136767
69Hemoptysis (HP:0002105)2.53894955
70Febrile seizures (HP:0002373)2.51633625
71Mutism (HP:0002300)2.50804281
72Pulmonary infiltrates (HP:0002113)2.49435087
73Leukocytosis (HP:0001974)2.48884684
74Paralysis (HP:0003470)2.46962677
75Eosinophilia (HP:0001880)2.46819743
76Lymphopenia (HP:0001888)2.44889817
77Epistaxis (HP:0000421)2.43441095
78Vertigo (HP:0002321)2.40211195
79Gastrointestinal stroma tumor (HP:0100723)2.38393043
80Thyroiditis (HP:0100646)2.36864805
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.36398818
82Abnormality of T cells (HP:0002843)2.35866117
83Episodic fever (HP:0001954)2.34144619
84Axonal loss (HP:0003447)2.33893889
85Recurrent lower respiratory tract infections (HP:0002783)2.31958583
86Encephalitis (HP:0002383)2.28254499
87Increased IgM level (HP:0003496)2.28132927
88Keratoconjunctivitis (HP:0001096)2.27944677
89Abnormality of T cell physiology (HP:0011840)2.26867155
90Urticaria (HP:0001025)2.26280323
91T lymphocytopenia (HP:0005403)2.25741580
92Pulmonary embolism (HP:0002204)2.25317381
93Impaired platelet aggregation (HP:0003540)2.25060086
94Abnormal platelet function (HP:0011869)2.25060086
95Arterial thrombosis (HP:0004420)2.24480291
96Abnormality of lateral ventricle (HP:0030047)2.24037065
97Gastrointestinal infarctions (HP:0005244)2.22685851
98Abnormality of T cell number (HP:0011839)2.21569320
99Recurrent bronchitis (HP:0002837)2.21010768
100Granulocytopenia (HP:0001913)2.19813418
101Urinary glycosaminoglycan excretion (HP:0003541)2.19685465
102Mucopolysacchariduria (HP:0008155)2.19685465
103Chest pain (HP:0100749)2.18845124
104Thoracic kyphosis (HP:0002942)2.18266578
105Abnormality of binocular vision (HP:0011514)2.18257414
106Diplopia (HP:0000651)2.18257414
107Restrictive lung disease (HP:0002091)2.16759969
108Abnormality of iron homeostasis (HP:0011031)2.15474593
109Keratoconjunctivitis sicca (HP:0001097)2.15245525
110Myocardial infarction (HP:0001658)2.15030356
111Sepsis (HP:0100806)2.14658691
112J-shaped sella turcica (HP:0002680)2.12361533
113Gingival bleeding (HP:0000225)2.11557818
114Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10909871
115Abnormality of polysaccharide metabolism (HP:0011012)2.10909871
116Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10909871
117Lymphoma (HP:0002665)2.09538117
118Joint hemorrhage (HP:0005261)2.09460815
119B lymphocytopenia (HP:0010976)2.08763851
120Abnormality of B cell number (HP:0010975)2.08763851
121Increased serum ferritin (HP:0003281)2.08529697
122Joint swelling (HP:0001386)2.06263313
123Hemiplegia (HP:0002301)2.06117634
124Exercise-induced myalgia (HP:0003738)2.04739562
125Albinism (HP:0001022)2.04073280
126Hepatosplenomegaly (HP:0001433)2.02851504
127Ventricular fibrillation (HP:0001663)2.02263432
128Interstitial pulmonary disease (HP:0006530)2.01895260
129Abnormality of eosinophils (HP:0001879)2.01133539
130Difficulty running (HP:0009046)1.99961862
131Skin ulcer (HP:0200042)1.99870836
132Polycythemia (HP:0001901)1.98803150
133Chronic diarrhea (HP:0002028)1.98192406
134Loss of speech (HP:0002371)1.89313355
135Polyneuropathy (HP:0001271)1.84582883
136Bruising susceptibility (HP:0000978)1.83827856
137Frequent falls (HP:0002359)1.82336908
138Memory impairment (HP:0002354)1.79045995
139Abnormality of transition element cation homeostasis (HP:0011030)1.79043533
140Gangrene (HP:0100758)1.76668133
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.75912210
142Distal arthrogryposis (HP:0005684)1.75498077
143Cerebral hemorrhage (HP:0001342)1.73594249
144Round ear (HP:0100830)1.73160352
145Exercise-induced muscle cramps (HP:0003710)1.72882596
146Anorexia (HP:0002039)1.72275358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.87584940
2IRAK43.79313376
3BLK3.66369264
4RIPK43.45325388
5KIT2.92255692
6MAP3K142.84859047
7TYK22.50246612
8IRAK32.45493688
9TEC2.45218843
10TGFBR22.32376168
11TXK2.24428649
12BTK2.24097884
13OBSCN2.19439083
14CSF1R2.13370376
15TBK11.99577345
16CLK11.96579751
17MAP2K31.88281536
18SYK1.80846542
19FES1.78075757
20ZAP701.73653664
21TAOK31.65206326
22TAOK11.60360538
23JAK11.57667430
24ITK1.54867196
25CSK1.52816648
26HCK1.50055709
27IKBKB1.46970403
28PIM21.46299212
29JAK31.46217071
30IKBKE1.45444767
31LYN1.44431751
32STK101.36051832
33GRK71.35221445
34LCK1.34437415
35MAP3K131.31046376
36GRK51.30563938
37TNIK1.28369293
38MATK1.23598524
39YES11.21286068
40PTK2B1.17460302
41MAP3K111.17018098
42BMX1.11732056
43IRAK11.11557276
44ERN11.10360159
45PIM11.09982499
46TRPM71.08827953
47MST41.08811054
48DAPK21.06767943
49SIK21.05266524
50SIK31.02099189
51MAP3K31.01920295
52RPS6KA41.01839531
53MYLK1.01433156
54NEK91.01346156
55EPHA31.00058965
56ADRBK20.99736144
57FLT30.91557536
58NME20.87354520
59MAP3K10.84225844
60IRAK20.83105385
61GRK60.82132923
62KDR0.81865673
63PINK10.80481018
64TRIM280.79348964
65EIF2AK20.78227728
66STK40.77748829
67FYN0.77321482
68MAP3K50.76243797
69MAP3K120.76114004
70VRK10.75656121
71JAK20.74599609
72PHKG10.73761753
73PHKG20.73761753
74TNK20.68945295
75TTN0.67624811
76TIE10.66344690
77MAP3K60.65651327
78EIF2AK30.65649250
79LRRK20.65529832
80FGFR30.65095740
81PRKG10.64335835
82CAMKK20.64155349
83SGK20.63790285
84RPS6KA60.63626999
85FRK0.62839059
86CDK60.62252070
87MAP2K40.62108370
88CHUK0.61577920
89MAP2K60.61074668
90MAPK40.59950286
91RET0.58956964
92EEF2K0.58076304
93MAP3K100.57804716
94NTRK30.57183709
95KSR10.56585441
96KSR20.55620174
97CAMK1D0.54778518
98TAOK20.54301081
99PIK3CG0.53512643
100RPS6KC10.52763928
101RPS6KL10.52763928
102SGK30.52273148
103STK240.51687091
104SCYL20.51530328
105ABL10.50914581
106PRKCD0.50857557
107CDC70.50506258
108PAK40.49871315
109MAPK130.48943698
110PDPK10.48475800
111FER0.46651347
112MARK20.46497778
113MAPKAPK20.46059139
114PRKD10.45670765
115STK160.45278632
116EPHB10.42744161
117PKN10.42679357
118ATR0.42462278
119PLK20.41118567
120MARK30.40697002
121ACVR1B0.40554419
122BMPR20.40197811
123BMPR1B0.39992057
124EGFR0.39903061
125CDK40.38708060
126PDK10.38208676
127NLK0.38142456
128CAMK2A0.37480223
129MOS0.36083760
130MAPK120.35518876
131PRKACG0.35420490
132ILK0.35416151
133MINK10.32615475
134TESK20.32508538
135FGR0.32321205
136CCNB10.32200230
137MAPK70.32187059
138DAPK10.31868954
139DYRK1B0.31736138
140NEK20.31466311
141GRK10.31122891
142CDK80.31034574
143PRKCQ0.31011368
144RPS6KA20.30991525
145ERBB30.29529733
146TGFBR10.29276737
147MKNK10.28012852

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.11034988
2Staphylococcus aureus infection_Homo sapiens_hsa051502.55488545
3Osteoclast differentiation_Homo sapiens_hsa043802.52393206
4B cell receptor signaling pathway_Homo sapiens_hsa046622.48010690
5Other glycan degradation_Homo sapiens_hsa005112.34593292
6Primary immunodeficiency_Homo sapiens_hsa053402.33723756
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.20895978
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.18964963
9Hematopoietic cell lineage_Homo sapiens_hsa046402.18603596
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.16271280
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.07386435
12Pertussis_Homo sapiens_hsa051332.02014315
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99893984
14Tuberculosis_Homo sapiens_hsa051521.99626685
15Measles_Homo sapiens_hsa051621.94821252
16Antigen processing and presentation_Homo sapiens_hsa046121.93736544
17Legionellosis_Homo sapiens_hsa051341.89055856
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82978590
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80669648
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.80292603
21Lysosome_Homo sapiens_hsa041421.79347715
22DNA replication_Homo sapiens_hsa030301.71281849
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71112385
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68857547
25Graft-versus-host disease_Homo sapiens_hsa053321.67605837
26Malaria_Homo sapiens_hsa051441.55480787
27Phagosome_Homo sapiens_hsa041451.51952342
28Allograft rejection_Homo sapiens_hsa053301.50500698
29Herpes simplex infection_Homo sapiens_hsa051681.48492068
30Influenza A_Homo sapiens_hsa051641.48161112
31Toxoplasmosis_Homo sapiens_hsa051451.47001548
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44229185
33Chemokine signaling pathway_Homo sapiens_hsa040621.41988842
34Salmonella infection_Homo sapiens_hsa051321.40968434
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37352479
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36962149
37Asthma_Homo sapiens_hsa053101.32940865
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30078497
39Shigellosis_Homo sapiens_hsa051311.29078586
40Collecting duct acid secretion_Homo sapiens_hsa049661.28778832
41Homologous recombination_Homo sapiens_hsa034401.27491918
42Long-term depression_Homo sapiens_hsa047301.27140069
43Rheumatoid arthritis_Homo sapiens_hsa053231.26436349
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.26033562
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.24768777
46Apoptosis_Homo sapiens_hsa042101.24448936
47Nitrogen metabolism_Homo sapiens_hsa009101.21293805
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16346084
49T cell receptor signaling pathway_Homo sapiens_hsa046601.12519875
50Hepatitis B_Homo sapiens_hsa051611.12190415
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11011125
52TNF signaling pathway_Homo sapiens_hsa046681.09750464
53Platelet activation_Homo sapiens_hsa046111.05511150
54Base excision repair_Homo sapiens_hsa034101.05495500
55Morphine addiction_Homo sapiens_hsa050321.03136745
56Long-term potentiation_Homo sapiens_hsa047200.99882775
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99268737
58Viral myocarditis_Homo sapiens_hsa054160.98458448
59Mismatch repair_Homo sapiens_hsa034300.98146026
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97754176
61Non-homologous end-joining_Homo sapiens_hsa034500.96648287
62Acute myeloid leukemia_Homo sapiens_hsa052210.96512904
63Circadian entrainment_Homo sapiens_hsa047130.93545600
64GABAergic synapse_Homo sapiens_hsa047270.92636935
65Serotonergic synapse_Homo sapiens_hsa047260.91835893
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88234142
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85440313
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.84911655
69Epstein-Barr virus infection_Homo sapiens_hsa051690.83755729
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79694882
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77223759
72African trypanosomiasis_Homo sapiens_hsa051430.76295731
73Fanconi anemia pathway_Homo sapiens_hsa034600.75227063
74Pancreatic cancer_Homo sapiens_hsa052120.75097027
75Oxytocin signaling pathway_Homo sapiens_hsa049210.74723863
76Chronic myeloid leukemia_Homo sapiens_hsa052200.74606012
77Gap junction_Homo sapiens_hsa045400.73892487
78Renin secretion_Homo sapiens_hsa049240.72795578
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72737036
80Ribosome_Homo sapiens_hsa030100.71888219
81Gastric acid secretion_Homo sapiens_hsa049710.71874524
82Cholinergic synapse_Homo sapiens_hsa047250.71322909
83Hepatitis C_Homo sapiens_hsa051600.70931114
84Glutamatergic synapse_Homo sapiens_hsa047240.70535025
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.69498841
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66887076
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65497571
88Type I diabetes mellitus_Homo sapiens_hsa049400.65316359
89Calcium signaling pathway_Homo sapiens_hsa040200.65146176
90Autoimmune thyroid disease_Homo sapiens_hsa053200.64044021
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.63556976
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62617008
93Renin-angiotensin system_Homo sapiens_hsa046140.62482408
94Olfactory transduction_Homo sapiens_hsa047400.60045440
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54982902
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54903309
97Synaptic vesicle cycle_Homo sapiens_hsa047210.54780052
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53613381
99Regulation of autophagy_Homo sapiens_hsa041400.53448663
100GnRH signaling pathway_Homo sapiens_hsa049120.53305272
101Pancreatic secretion_Homo sapiens_hsa049720.50723556
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50501927
103Rap1 signaling pathway_Homo sapiens_hsa040150.49531979
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.49477378
105HTLV-I infection_Homo sapiens_hsa051660.49208649
106Dopaminergic synapse_Homo sapiens_hsa047280.49140709
107Viral carcinogenesis_Homo sapiens_hsa052030.47118634
108Dorso-ventral axis formation_Homo sapiens_hsa043200.43729502
109Salivary secretion_Homo sapiens_hsa049700.43605336
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43203115
111N-Glycan biosynthesis_Homo sapiens_hsa005100.42777954
112Arachidonic acid metabolism_Homo sapiens_hsa005900.42317880
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41754993
114MAPK signaling pathway_Homo sapiens_hsa040100.39630532
115Colorectal cancer_Homo sapiens_hsa052100.38987719
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38371856
117HIF-1 signaling pathway_Homo sapiens_hsa040660.38085704
118Nucleotide excision repair_Homo sapiens_hsa034200.36618620
119Sphingolipid metabolism_Homo sapiens_hsa006000.36597704
120Non-small cell lung cancer_Homo sapiens_hsa052230.36095779
121VEGF signaling pathway_Homo sapiens_hsa043700.36046266
122Notch signaling pathway_Homo sapiens_hsa043300.35804392
123Caffeine metabolism_Homo sapiens_hsa002320.35478318
124Amoebiasis_Homo sapiens_hsa051460.34707374
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33912934
126Small cell lung cancer_Homo sapiens_hsa052220.33784387
127p53 signaling pathway_Homo sapiens_hsa041150.31683258
128Complement and coagulation cascades_Homo sapiens_hsa046100.31489191
129Systemic lupus erythematosus_Homo sapiens_hsa053220.30982325
130Endocytosis_Homo sapiens_hsa041440.30677914
131Pentose phosphate pathway_Homo sapiens_hsa000300.28865186
132Spliceosome_Homo sapiens_hsa030400.27464565
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27334263
134Cell cycle_Homo sapiens_hsa041100.27273955
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26890435
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26750275

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