TM4SF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.74082017
2Golgi transport vesicle coating (GO:0048200)8.74082017
3endocrine pancreas development (GO:0031018)6.80551140
4COPII vesicle coating (GO:0048208)6.11585186
5signal peptide processing (GO:0006465)5.98564326
6peptide hormone processing (GO:0016486)5.82845253
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.59528967
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.54961467
9L-phenylalanine catabolic process (GO:0006559)5.54961467
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.48445711
11negative regulation of execution phase of apoptosis (GO:1900118)5.41131136
12L-phenylalanine metabolic process (GO:0006558)5.16700270
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.16700270
14positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003575.06439952
15sequestering of metal ion (GO:0051238)5.05128335
16glandular epithelial cell differentiation (GO:0002067)5.04737582
17protein retention in ER lumen (GO:0006621)4.95263059
18cellular ketone body metabolic process (GO:0046950)4.94078111
19protein maturation by protein folding (GO:0022417)4.78133043
20glycerophospholipid catabolic process (GO:0046475)4.64071777
21positive regulation of insulin secretion (GO:0032024)4.54745877
22epithelial cell fate commitment (GO:0072148)4.44696144
23regulation of type B pancreatic cell apoptotic process (GO:2000674)4.41270205
24auditory receptor cell differentiation (GO:0042491)4.40431326
25positive regulation of gluconeogenesis (GO:0045722)4.39136435
26regulation of extracellular matrix disassembly (GO:0010715)4.39133378
27ketone body metabolic process (GO:1902224)4.35182655
28phenylpropanoid metabolic process (GO:0009698)4.33781989
29positive regulation of histone H3-K4 methylation (GO:0051571)4.21496933
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.20937486
31inositol phosphate catabolic process (GO:0071545)4.10319221
32intestinal cholesterol absorption (GO:0030299)4.07237840
33vesicle coating (GO:0006901)4.03011867
34insulin secretion (GO:0030073)4.02348571
35inositol phosphate dephosphorylation (GO:0046855)3.95285718
36phosphorylated carbohydrate dephosphorylation (GO:0046838)3.95285718
37activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.94738186
38aromatic amino acid family catabolic process (GO:0009074)3.88949195
39positive regulation of peptide hormone secretion (GO:0090277)3.84206859
40ER overload response (GO:0006983)3.83216436
41cellular zinc ion homeostasis (GO:0006882)3.79592352
42regulation of fibrinolysis (GO:0051917)3.79396553
43intestinal absorption (GO:0050892)3.74711702
44positive regulation of nuclease activity (GO:0032075)3.72049531
45exocrine pancreas development (GO:0031017)3.71780258
46regulation of insulin secretion (GO:0050796)3.70529613
47regulation of glucokinase activity (GO:0033131)3.70010513
48regulation of hexokinase activity (GO:1903299)3.70010513
49positive regulation of peptide secretion (GO:0002793)3.69300578
50water-soluble vitamin biosynthetic process (GO:0042364)3.69055490
51nitric oxide biosynthetic process (GO:0006809)3.68008365
52respiratory chain complex IV assembly (GO:0008535)3.60375909
53negative regulation of complement activation (GO:0045916)3.56224365
54L-alpha-amino acid transmembrane transport (GO:1902475)3.54452472
55regulation of execution phase of apoptosis (GO:1900117)3.52515551
56toxin metabolic process (GO:0009404)3.50964296
57ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.50157719
583-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.47636032
59purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.47636032
60regulation of peptide hormone secretion (GO:0090276)3.46835527
61protein autoprocessing (GO:0016540)3.44050282
62retinol metabolic process (GO:0042572)3.42614447
63cytochrome complex assembly (GO:0017004)3.40209848
64regulation of peptide secretion (GO:0002791)3.39534411
65endoplasmic reticulum unfolded protein response (GO:0030968)3.38983410
66cellular response to unfolded protein (GO:0034620)3.38089528
67regulation of nuclease activity (GO:0032069)3.37483198
68negative regulation of protein activation cascade (GO:2000258)3.36725060
69tyrosine metabolic process (GO:0006570)3.32434169
70cellular response to topologically incorrect protein (GO:0035967)3.31687701
71glandular epithelial cell development (GO:0002068)3.29750580
72macroautophagy (GO:0016236)3.28928363
73type B pancreatic cell development (GO:0003323)3.26230981
74polyol catabolic process (GO:0046174)3.25405237
75xenobiotic catabolic process (GO:0042178)3.24461488
76intra-Golgi vesicle-mediated transport (GO:0006891)3.23059815
77ER-nucleus signaling pathway (GO:0006984)3.22843444
78regulation of cholesterol homeostasis (GO:2000188)3.20772051
79acylglycerol homeostasis (GO:0055090)3.18798777
80triglyceride homeostasis (GO:0070328)3.18798777
81S-adenosylmethionine metabolic process (GO:0046500)3.17727487
82negative regulation of digestive system process (GO:0060457)3.17007448
83ER to Golgi vesicle-mediated transport (GO:0006888)3.15517959
84regulation of glucocorticoid secretion (GO:2000849)3.15446745
85positive regulation of calcium ion import (GO:0090280)3.14240436
86nodal signaling pathway (GO:0038092)3.13544871
87positive regulation of glycolytic process (GO:0045821)3.09333453
88triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.06178979
89negative regulation of glycoprotein biosynthetic process (GO:0010561)3.05517404
90regulation of Golgi to plasma membrane protein transport (GO:0042996)3.03396675
91positive regulation of hormone secretion (GO:0046887)3.03196288
92peptide metabolic process (GO:0006518)3.03168312
93regulation of hormone secretion (GO:0046883)3.01954651
94protein carboxylation (GO:0018214)2.99817696
95peptidyl-glutamic acid carboxylation (GO:0017187)2.99817696
96sphingomyelin metabolic process (GO:0006684)2.98767437
97protein N-linked glycosylation via asparagine (GO:0018279)2.96925705
98negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96329680
99response to hexose (GO:0009746)2.95297188
100peptidyl-asparagine modification (GO:0018196)2.95263920
101peptide hormone secretion (GO:0030072)2.94920837
102aromatic amino acid family metabolic process (GO:0009072)2.94241115
103high-density lipoprotein particle remodeling (GO:0034375)2.93493784
104positive regulation of fatty acid biosynthetic process (GO:0045723)2.92037353
105nitric oxide mediated signal transduction (GO:0007263)2.91484903
106peptide secretion (GO:0002790)2.90989058
107reverse cholesterol transport (GO:0043691)2.87648917
108response to glucose (GO:0009749)2.87301628
109regulation of cholesterol esterification (GO:0010872)2.87222984
110phospholipid catabolic process (GO:0009395)2.85504932
111inner ear receptor cell differentiation (GO:0060113)2.85070243
112phospholipid efflux (GO:0033700)2.83878812
113heme transport (GO:0015886)2.83841038
114zinc ion homeostasis (GO:0055069)2.83706255
115response to endoplasmic reticulum stress (GO:0034976)2.82032063
116bile acid and bile salt transport (GO:0015721)2.81666015
117columnar/cuboidal epithelial cell development (GO:0002066)2.81472526
118detection of calcium ion (GO:0005513)2.81273274
119response to monosaccharide (GO:0034284)2.79997028
120nucleotide transmembrane transport (GO:1901679)2.79841425
121lipoprotein metabolic process (GO:0042157)2.79716739
122epoxygenase P450 pathway (GO:0019373)2.79024066
123pteridine-containing compound biosynthetic process (GO:0042559)2.78636605
124drug catabolic process (GO:0042737)2.78284046
125lactate metabolic process (GO:0006089)2.77214945
1264-hydroxyproline metabolic process (GO:0019471)2.76738805
127protein localization to Golgi apparatus (GO:0034067)2.76411080
128carbohydrate homeostasis (GO:0033500)2.76067273
129glucose homeostasis (GO:0042593)2.76067273
130regulation of peptide transport (GO:0090087)2.75054221
131hormone catabolic process (GO:0042447)2.74752210
132bile acid metabolic process (GO:0008206)2.74614523
133sulfur amino acid catabolic process (GO:0000098)2.74540257
134drug transmembrane transport (GO:0006855)2.74352253
135purine nucleoside bisphosphate metabolic process (GO:0034032)2.73976339
136alanine transport (GO:0032328)2.72131703
137hair cell differentiation (GO:0035315)2.70524888
138ethanol oxidation (GO:0006069)2.67752313
139regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.67383668
140basic amino acid transport (GO:0015802)2.65543929
141inositol phosphate-mediated signaling (GO:0048016)2.63851944
142toxin transport (GO:1901998)2.63660274
143negative regulation of humoral immune response (GO:0002921)2.61079332
144iron coordination entity transport (GO:1901678)2.60214227
145regulation of mitochondrial translation (GO:0070129)2.58986891
146magnesium ion transport (GO:0015693)2.57275767
147potassium ion export (GO:0071435)2.55613473
148nephron epithelium morphogenesis (GO:0072088)2.55468911
149nephron tubule morphogenesis (GO:0072078)2.55468911
150positive regulation of macroautophagy (GO:0016239)2.55030390
151exogenous drug catabolic process (GO:0042738)2.55021252
152C-terminal protein lipidation (GO:0006501)2.54930826
153regulation of acrosome reaction (GO:0060046)2.53999567
154protein complex biogenesis (GO:0070271)2.49284861
155oxidative demethylation (GO:0070989)2.49224934
156organic cation transport (GO:0015695)2.47668012
157phospholipid dephosphorylation (GO:0046839)2.47095756
158brain morphogenesis (GO:0048854)2.45895236
159regulation of Rac protein signal transduction (GO:0035020)2.45376374
160astrocyte differentiation (GO:0048708)2.44794660
161somite rostral/caudal axis specification (GO:0032525)2.42186021
162regulation of autophagic vacuole assembly (GO:2000785)2.41942113
163peptide transport (GO:0015833)2.41170086
164positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.40705410
165cellular glucuronidation (GO:0052695)2.39978149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.49112242
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.07599581
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.13363621
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.33841497
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.31976888
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.91127853
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.72962435
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.71943028
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.57589442
10GATA1_22025678_ChIP-Seq_K562_Human3.56191565
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.98769774
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.89727793
13GBX2_23144817_ChIP-Seq_PC3_Human2.78975726
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69993395
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.20241773
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17100643
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.15753821
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06508087
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.04633805
20IGF1R_20145208_ChIP-Seq_DFB_Human1.85908121
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75493941
22ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.71099524
23FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.69310869
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68974836
25* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68858426
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66674980
27TAF15_26573619_Chip-Seq_HEK293_Human1.65306136
28FUS_26573619_Chip-Seq_HEK293_Human1.63737763
29CLOCK_20551151_ChIP-Seq_293T_Human1.63684053
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63343394
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51180615
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.49981015
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48910462
34FOXA1_25552417_ChIP-Seq_VCAP_Human1.47611635
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.46504523
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45916900
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45767224
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.43935177
39ER_23166858_ChIP-Seq_MCF-7_Human1.42899694
40P300_19829295_ChIP-Seq_ESCs_Human1.42468792
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.40990224
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38692763
43* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36501508
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.36233406
45AR_25329375_ChIP-Seq_VCAP_Human1.36233177
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.33582444
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33227933
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32860105
49P53_22387025_ChIP-Seq_ESCs_Mouse1.32792284
50STAT3_18555785_Chip-Seq_ESCs_Mouse1.32616156
51SOX2_18555785_Chip-Seq_ESCs_Mouse1.32388659
52GATA4_25053715_ChIP-Seq_YYC3_Human1.32363991
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31080253
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.30448953
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29983201
56REST_19997604_ChIP-ChIP_NEURONS_Mouse1.29684577
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29600392
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29441316
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.28907825
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.26946563
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26364221
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26331881
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25972195
64EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25173625
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25109977
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24137426
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23837980
68CDX2_22108803_ChIP-Seq_LS180_Human1.23776113
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23695503
70TCF4_23295773_ChIP-Seq_U87_Human1.20140135
71NMYC_18555785_Chip-Seq_ESCs_Mouse1.18389514
72* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16733934
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16206502
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14911136
75* CMYC_18555785_Chip-Seq_ESCs_Mouse1.14734285
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14295208
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13423527
78* E2F1_18555785_Chip-Seq_ESCs_Mouse1.13377799
79CTCF_18555785_Chip-Seq_ESCs_Mouse1.12672193
80* SOX2_20726797_ChIP-Seq_SW620_Human1.12288250
81NANOG_19829295_ChIP-Seq_ESCs_Human1.12129480
82SOX2_19829295_ChIP-Seq_ESCs_Human1.12129480
83OCT4_18555785_Chip-Seq_ESCs_Mouse1.12085895
84FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.11736398
85TCF4_22108803_ChIP-Seq_LS180_Human1.11593262
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11205528
87P300_18555785_Chip-Seq_ESCs_Mouse1.10331269
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08491982
89ERG_20517297_ChIP-Seq_VCAP_Human1.07687659
90* HNF4A_19822575_ChIP-Seq_HepG2_Human1.07481078
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06881107
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04627343
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04590920
94CBP_20019798_ChIP-Seq_JUKART_Human1.03175687
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03175687
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01711040
97ZFX_18555785_Chip-Seq_ESCs_Mouse1.01217139
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00960721
99AR_20517297_ChIP-Seq_VCAP_Human1.00233755
100RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99994129
101SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99806693
102CRX_20693478_ChIP-Seq_RETINA_Mouse0.98806663
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98222709
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97686477
105HTT_18923047_ChIP-ChIP_STHdh_Human0.96696784
106PHF8_20622853_ChIP-Seq_HELA_Human0.96531113
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96444841
108KLF4_18555785_Chip-Seq_ESCs_Mouse0.96117918
109GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95674889
110GATA1_19941826_ChIP-Seq_K562_Human0.95522210
111RUNX2_22187159_ChIP-Seq_PCA_Human0.94603122
112FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94384122
113TRIM28_21343339_ChIP-Seq_HEK293_Human0.94130570
114GABP_17652178_ChIP-ChIP_JURKAT_Human0.92794312
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91760420
116PIAS1_25552417_ChIP-Seq_VCAP_Human0.90656179
117GATA6_25053715_ChIP-Seq_YYC3_Human0.90482198
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90456226
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87661829
120* GATA3_24758297_ChIP-Seq_MCF-7_Human0.87040168
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86935630
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86910113
123TFEB_21752829_ChIP-Seq_HELA_Human0.86380448
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84999939
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84999939
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84641211
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82802661
128KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82022398
129EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81461053
130PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80118128
131ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79511694
132RARA_24833708_ChIP-Seq_LIVER_Mouse0.77952292
133FOXA1_25329375_ChIP-Seq_VCAP_Human0.77061302
134FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77061302
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76633586
136VDR_22108803_ChIP-Seq_LS180_Human0.75763900
137RARB_24833708_ChIP-Seq_LIVER_Mouse0.75164309
138POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72126680
139ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72104350
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71849890
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70645889
142SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69674798
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.69023791
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67781766
145* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.67069956
146REST_21632747_ChIP-Seq_MESCs_Mouse0.65641471
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.65569106
148FOXA1_21572438_ChIP-Seq_LNCaP_Human0.64889817
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.64641123
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.64523364
151BCAT_22108803_ChIP-Seq_LS180_Human0.64103466
152TP53_22573176_ChIP-Seq_HFKS_Human0.62111679
153REST_18959480_ChIP-ChIP_MESCs_Mouse0.61886535
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.60954549
155SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60639482
156STAT3_23295773_ChIP-Seq_U87_Human0.60535547
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60168967
158NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.60002030
159ZNF274_21170338_ChIP-Seq_K562_Hela0.59763829
160SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.59331897
161FLI1_21867929_ChIP-Seq_TH2_Mouse0.58930609
162CHD1_26751641_Chip-Seq_LNCaP_Human0.57838779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.42973295
2MP0003195_calcinosis4.64386175
3MP0002877_abnormal_melanocyte_morpholog4.20380510
4MP0005365_abnormal_bile_salt3.96023383
5MP0000013_abnormal_adipose_tissue3.69476080
6MP0004043_abnormal_pH_regulation3.52611232
7MP0003183_abnormal_peptide_metabolism3.50859790
8MP0005085_abnormal_gallbladder_physiolo3.25150812
9MP0002693_abnormal_pancreas_physiology3.24845705
10MP0001944_abnormal_pancreas_morphology3.20415595
11MP0005360_urolithiasis3.16268466
12MP0003252_abnormal_bile_duct3.04768683
13MP0002138_abnormal_hepatobiliary_system2.96980927
14MP0009780_abnormal_chondrocyte_physiolo2.93151592
15MP0005379_endocrine/exocrine_gland_phen2.92484271
16MP0010386_abnormal_urinary_bladder2.89384552
17MP0003283_abnormal_digestive_organ2.83330904
18MP0002909_abnormal_adrenal_gland2.78153590
19MP0005220_abnormal_exocrine_pancreas2.75619281
20MP0002254_reproductive_system_inflammat2.58923752
21MP0000678_abnormal_parathyroid_gland2.56508670
22MP0002837_dystrophic_cardiac_calcinosis2.48711737
23MP0001666_abnormal_nutrient_absorption2.35546037
24MP0008875_abnormal_xenobiotic_pharmacok2.34828176
25MP0003787_abnormal_imprinting2.24512596
26MP0002078_abnormal_glucose_homeostasis2.19620301
27MP0003868_abnormal_feces_composition2.04338530
28MP0003806_abnormal_nucleotide_metabolis1.94988853
29MP0004264_abnormal_extraembryonic_tissu1.90280327
30MP0000003_abnormal_adipose_tissue1.89335438
31MP0010329_abnormal_lipoprotein_level1.82551357
32MP0002928_abnormal_bile_duct1.80507355
33MP0008877_abnormal_DNA_methylation1.65063475
34MP0009643_abnormal_urine_homeostasis1.64249719
35MP0005084_abnormal_gallbladder_morpholo1.61678106
36MP0009840_abnormal_foam_cell1.57799758
37MP0006072_abnormal_retinal_apoptosis1.56060273
38MP0005645_abnormal_hypothalamus_physiol1.53283896
39MP0003300_gastrointestinal_ulcer1.52350094
40MP0009046_muscle_twitch1.50753770
41MP0002118_abnormal_lipid_homeostasis1.49172408
42MP0005332_abnormal_amino_acid1.45419203
43MP0005083_abnormal_biliary_tract1.43399493
44MP0001501_abnormal_sleep_pattern1.40974848
45MP0005636_abnormal_mineral_homeostasis1.39038559
46MP0005646_abnormal_pituitary_gland1.37333334
47MP0002876_abnormal_thyroid_physiology1.37207319
48MP0003953_abnormal_hormone_level1.32850137
49MP0000609_abnormal_liver_physiology1.32704549
50MP0004019_abnormal_vitamin_homeostasis1.31295616
51MP0001756_abnormal_urination1.29700511
52MP0001765_abnormal_ion_homeostasis1.29114502
53MP0005248_abnormal_Harderian_gland1.25133475
54MP0003011_delayed_dark_adaptation1.24394159
55MP0005551_abnormal_eye_electrophysiolog1.20448075
56MP0005058_abnormal_lysosome_morphology1.19724476
57MP0001764_abnormal_homeostasis1.16864349
58MP0004133_heterotaxia1.15822786
59MP0005408_hypopigmentation1.15779312
60MP0002638_abnormal_pupillary_reflex1.14338373
61MP0000613_abnormal_salivary_gland1.11681623
62MP0005257_abnormal_intraocular_pressure1.10977751
63MP0002896_abnormal_bone_mineralization1.08662299
64MP0000462_abnormal_digestive_system1.07734411
65MP0008961_abnormal_basal_metabolism1.07518992
66MP0005535_abnormal_body_temperature1.02759126
67MP0003191_abnormal_cellular_cholesterol1.02695627
68MP0005448_abnormal_energy_balance1.02536978
69MP0003172_abnormal_lysosome_physiology1.02463724
70MP0001984_abnormal_olfaction1.01766178
71MP0009745_abnormal_behavioral_response1.00868330
72MP0001986_abnormal_taste_sensitivity1.00696679
73MP0002163_abnormal_gland_morphology0.99969131
74MP0003959_abnormal_lean_body0.98292002
75MP0001905_abnormal_dopamine_level0.94303843
76MP0000538_abnormal_urinary_bladder0.93871162
77MP0005319_abnormal_enzyme/_coenzyme0.92412411
78MP0008872_abnormal_physiological_respon0.90504521
79MP0000427_abnormal_hair_cycle0.90377838
80MP0010678_abnormal_skin_adnexa0.90024961
81MP0005375_adipose_tissue_phenotype0.89558241
82MP0004885_abnormal_endolymph0.89537921
83MP0004215_abnormal_myocardial_fiber0.88134502
84MP0009642_abnormal_blood_homeostasis0.86569211
85MP0005174_abnormal_tail_pigmentation0.85661204
86MP0002734_abnormal_mechanical_nocicepti0.82384366
87MP0000372_irregular_coat_pigmentation0.82266839
88MP0002938_white_spotting0.81752145
89MP0002733_abnormal_thermal_nociception0.81717218
90MP0001970_abnormal_pain_threshold0.81581813
91MP0003633_abnormal_nervous_system0.81124662
92MP0002557_abnormal_social/conspecific_i0.80373677
93MP0002064_seizures0.79039723
94MP0002272_abnormal_nervous_system0.78115749
95MP0006054_spinal_hemorrhage0.76660843
96MP0003122_maternal_imprinting0.76579573
97MP0000639_abnormal_adrenal_gland0.76307171
98MP0005670_abnormal_white_adipose0.75917361
99MP0004147_increased_porphyrin_level0.75653147
100MP0004924_abnormal_behavior0.75324926
101MP0005386_behavior/neurological_phenoty0.75324926
102MP0005334_abnormal_fat_pad0.73893324
103MP0000230_abnormal_systemic_arterial0.73600263
104MP0004085_abnormal_heartbeat0.73217728
105MP0003121_genomic_imprinting0.71172706
106MP0004270_analgesia0.68434524
107MP0001502_abnormal_circadian_rhythm0.68328360
108MP0002234_abnormal_pharynx_morphology0.68211744
109MP0001661_extended_life_span0.67561748
110MP0003186_abnormal_redox_activity0.66351506
111MP0002090_abnormal_vision0.66220521
112MP0001270_distended_abdomen0.63681315
113MP0000598_abnormal_liver_morphology0.62859790
114MP0003045_fibrosis0.62850455
115MP0002295_abnormal_pulmonary_circulatio0.62380078
116MP0002229_neurodegeneration0.60868705
117MP0003119_abnormal_digestive_system0.59879964
118MP0006036_abnormal_mitochondrial_physio0.59287925
119MP0003890_abnormal_embryonic-extraembry0.58657643
120MP0004142_abnormal_muscle_tone0.58540806
121MP0009672_abnormal_birth_weight0.57881276
122MP0003879_abnormal_hair_cell0.57037308
123MP0005310_abnormal_salivary_gland0.55000072
124MP0003866_abnormal_defecation0.52918298
125MP0002168_other_aberrant_phenotype0.51752776
126MP0000631_abnormal_neuroendocrine_gland0.51739142
127MP0005253_abnormal_eye_physiology0.50086498
128MP0005584_abnormal_enzyme/coenzyme_acti0.49675315
129MP0001664_abnormal_digestion0.48259642
130MP0000681_abnormal_thyroid_gland0.46767068
131MP0002971_abnormal_brown_adipose0.45034843
132MP0005452_abnormal_adipose_tissue0.44381414
133MP0002970_abnormal_white_adipose0.41332579
134MP0009697_abnormal_copulation0.40297990
135MP0002069_abnormal_eating/drinking_beha0.40055898
136MP0010234_abnormal_vibrissa_follicle0.39318268
137MP0003943_abnormal_hepatobiliary_system0.38026363
138MP0008469_abnormal_protein_level0.36869489

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.44293378
2Hypoglycemic seizures (HP:0002173)7.32614769
3Hypoglycemic coma (HP:0001325)7.07266369
4Symptomatic seizures (HP:0011145)6.82388854
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.64222921
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.34341285
7Hyperglycemia (HP:0003074)5.04665911
8Late onset (HP:0003584)4.68360900
9Ketoacidosis (HP:0001993)4.63798435
10Generalized aminoaciduria (HP:0002909)4.57025990
11Abnormality of the pancreatic islet cells (HP:0006476)4.37938956
12Abnormality of endocrine pancreas physiology (HP:0012093)4.37938956
13Double outlet right ventricle (HP:0001719)4.36481955
14Congenital malformation of the right heart (HP:0011723)4.36481955
15Abnormality of the intrinsic pathway (HP:0010989)4.06219233
16Pancreatic islet-cell hyperplasia (HP:0004510)4.02534470
17Increased CSF protein (HP:0002922)3.92375108
18Conjugated hyperbilirubinemia (HP:0002908)3.90701247
19Insulin-resistant diabetes mellitus (HP:0000831)3.85727784
20Abnormality of vitamin B metabolism (HP:0004340)3.84172920
21Intrahepatic cholestasis (HP:0001406)3.83115886
22Abnormality of vitamin metabolism (HP:0100508)3.71256789
23Vascular calcification (HP:0004934)3.70353488
24Ketosis (HP:0001946)3.65033695
25Abnormal pancreas size (HP:0012094)3.56177400
26Abnormality of calcium-phosphate metabolism (HP:0100530)3.55290813
27Prolonged partial thromboplastin time (HP:0003645)3.54335011
28Gout (HP:0001997)3.43698181
29Abnormality of monocarboxylic acid metabolism (HP:0010996)3.32339350
30Cardiovascular calcification (HP:0011915)3.20141706
31Abnormality of the common coagulation pathway (HP:0010990)3.18189925
32Large for gestational age (HP:0001520)3.15688733
33Proximal tubulopathy (HP:0000114)3.06828396
34Congenital sensorineural hearing impairment (HP:0008527)3.02219682
35Xanthomatosis (HP:0000991)2.99564684
36Mucopolysacchariduria (HP:0008155)2.93008219
37Urinary glycosaminoglycan excretion (HP:0003541)2.93008219
38Insulin resistance (HP:0000855)2.91161311
39Dysostosis multiplex (HP:0000943)2.89566697
40Osteomalacia (HP:0002749)2.89355965
41Methylmalonic acidemia (HP:0002912)2.85988772
42Hemiparesis (HP:0001269)2.81350872
43Retinal atrophy (HP:0001105)2.81301899
44Postural tremor (HP:0002174)2.77737036
45Decreased circulating renin level (HP:0003351)2.74351636
46Hypobetalipoproteinemia (HP:0003563)2.70882184
47Abnormality of the renal cortex (HP:0011035)2.66947274
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.65832424
49Abnormality of polysaccharide metabolism (HP:0011012)2.65832424
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.65832424
51Abnormality of purine metabolism (HP:0004352)2.64424794
52Abnormality of urine glucose concentration (HP:0011016)2.64336266
53Glycosuria (HP:0003076)2.64336266
54Hypoalbuminemia (HP:0003073)2.61933781
55Abnormal albumin level (HP:0012116)2.61933781
56Abdominal distention (HP:0003270)2.61285456
57Enlarged penis (HP:0000040)2.56573510
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.55508378
59Orthostatic hypotension (HP:0001278)2.52002276
60Progressive macrocephaly (HP:0004481)2.43835321
61Hypokalemia (HP:0002900)2.43508987
62Fat malabsorption (HP:0002630)2.42143374
63Methylmalonic aciduria (HP:0012120)2.40671993
64Enlarged kidneys (HP:0000105)2.35720679
65Protuberant abdomen (HP:0001538)2.34185665
66Limb hypertonia (HP:0002509)2.34168134
673-Methylglutaconic aciduria (HP:0003535)2.31671112
68Irritability (HP:0000737)2.30704045
69Hyperparathyroidism (HP:0000843)2.30331327
70Deep venous thrombosis (HP:0002625)2.29369041
71Abnormality of renal resorption (HP:0011038)2.27242727
72Hyperbilirubinemia (HP:0002904)2.26990240
73Medial flaring of the eyebrow (HP:0010747)2.26982984
74Prominent metopic ridge (HP:0005487)2.26753994
75Agitation (HP:0000713)2.26261646
76Hypophosphatemia (HP:0002148)2.23811577
77Skin nodule (HP:0200036)2.22680041
78Unilateral renal agenesis (HP:0000122)2.22185002
79Dysautonomia (HP:0002459)2.21116568
80Acute necrotizing encephalopathy (HP:0006965)2.20172079
81Exocrine pancreatic insufficiency (HP:0001738)2.19943936
82Renal Fanconi syndrome (HP:0001994)2.18402557
83Mesangial abnormality (HP:0001966)2.17996154
84Urethral obstruction (HP:0000796)2.17583056
85Cardiomegaly (HP:0001640)2.16639001
86Hyperphosphaturia (HP:0003109)2.15894742
87Conjunctival hamartoma (HP:0100780)2.11615580
88Tubular atrophy (HP:0000092)2.11530802
89Joint hemorrhage (HP:0005261)2.11188806
90Hypothermia (HP:0002045)2.10114740
91Hyperthyroidism (HP:0000836)2.08936692
92Mitral stenosis (HP:0001718)2.08648542
93Epidermoid cyst (HP:0200040)2.08158373
94Zonular cataract (HP:0010920)2.06273052
95Progressive neurologic deterioration (HP:0002344)2.05996827
96Abnormality of fatty-acid metabolism (HP:0004359)2.04611338
97Poor suck (HP:0002033)2.03477324
98Abnormal enzyme/coenzyme activity (HP:0012379)2.02084204
99Abnormality of alkaline phosphatase activity (HP:0004379)2.01690765
100Acute hepatic failure (HP:0006554)2.00748429
101Abnormality of potassium homeostasis (HP:0011042)2.00547990
102EEG with generalized epileptiform discharges (HP:0011198)1.98794732
103Abnormality of nucleobase metabolism (HP:0010932)1.98786464
104Pancreatic cysts (HP:0001737)1.98738044
105Hypsarrhythmia (HP:0002521)1.97986344
106Hyperkalemia (HP:0002153)1.96045242
107Hypoplasia of the fovea (HP:0007750)1.95695247
108Aplasia/Hypoplasia of the fovea (HP:0008060)1.95695247
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95641822
110Abnormal protein N-linked glycosylation (HP:0012347)1.95641822
111Abnormal protein glycosylation (HP:0012346)1.95641822
112Abnormal glycosylation (HP:0012345)1.95641822
113Elevated alkaline phosphatase (HP:0003155)1.95589816
114Acute encephalopathy (HP:0006846)1.95587949
115Attenuation of retinal blood vessels (HP:0007843)1.94948720
116Pancreatic fibrosis (HP:0100732)1.94737122
117Hematochezia (HP:0002573)1.94445137
118Arthropathy (HP:0003040)1.94175253
119Nuclear cataract (HP:0100018)1.93744988
120Severe visual impairment (HP:0001141)1.92440111
121Mitochondrial inheritance (HP:0001427)1.92077928
122Lipid accumulation in hepatocytes (HP:0006561)1.89099833
123Hyperlipoproteinemia (HP:0010980)1.88883257
124Hypolipoproteinemia (HP:0010981)1.88395273
125Gastrointestinal atresia (HP:0002589)1.87610055
126Epileptiform EEG discharges (HP:0011182)1.87551482
127Neuroendocrine neoplasm (HP:0100634)1.86874368
128Death in childhood (HP:0003819)1.86870413
129Abnormality of the vitreous humor (HP:0004327)1.86158381
130Hamartoma of the eye (HP:0010568)1.86013882
131Steatorrhea (HP:0002570)1.85906177
132Episodic fever (HP:0001954)1.84727239
133Abnormal rod and cone electroretinograms (HP:0008323)1.84228283
134Abnormality of the metopic suture (HP:0005556)1.83624854
135Furrowed tongue (HP:0000221)1.83340865
136Syncope (HP:0001279)1.82942195
137Hyperphosphatemia (HP:0002905)1.81903455
138Hypokinesia (HP:0002375)1.81031268
139Abnormality of the fovea (HP:0000493)1.81030988
140Intestinal atresia (HP:0011100)1.80799740
141Dicarboxylic aciduria (HP:0003215)1.80296032
142Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80296032
143Pheochromocytoma (HP:0002666)1.80201522
144Generalized hyperpigmentation (HP:0007440)1.80108355
145Complement deficiency (HP:0004431)1.79824694
146Congenital stationary night blindness (HP:0007642)1.79778874
147Abnormality of renal excretion (HP:0011036)1.79730567
148Testicular neoplasm (HP:0010788)1.79089800
149Abnormal biliary tract morphology (HP:0012440)1.78030471
150Muscular hypotonia of the trunk (HP:0008936)1.77893240
151Abnormality of renin-angiotensin system (HP:0000847)1.77584245
152Abnormality of sulfur amino acid metabolism (HP:0004339)1.77126467
153Aqueductal stenosis (HP:0002410)1.76839353
154Polydipsia (HP:0001959)1.76692382
155Abnormal drinking behavior (HP:0030082)1.76692382
156Lethargy (HP:0001254)1.76503870
157Hyperactive renin-angiotensin system (HP:0000841)1.75794878
158Vacuolated lymphocytes (HP:0001922)1.74689463
159Hypotension (HP:0002615)1.74339706
160Renal cortical cysts (HP:0000803)1.73721099
161Cortical visual impairment (HP:0100704)1.73081210
162Increased purine levels (HP:0004368)1.68250399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.59258780
2MAPK155.81746630
3PASK4.12896749
4FRK3.98674940
5MST43.58055353
6TAOK33.19163524
7MAP3K23.13901442
8MAP4K23.04055470
9FGFR22.96993403
10PHKG22.93339473
11PHKG12.93339473
12WNK32.92227905
13GRK12.90143618
14PRKD32.73633008
15ERN12.63237805
16HIPK22.47475696
17DAPK22.46765215
18WNK42.39423525
19MAP2K62.38878676
20MAP3K122.21761071
21FLT32.12944807
22PIK3CG2.02922199
23BCKDK2.02159990
24ADRBK21.98947689
25MAP3K41.98193171
26IRAK31.90266338
27ACVR1B1.85272548
28PINK11.60838330
29STK31.58550496
30IRAK11.56989689
31CASK1.56195671
32EPHA31.51586279
33TRPM71.51522773
34PTK61.47900142
35STK241.45157355
36NTRK11.38462905
37MAP3K91.37258393
38FGFR41.35631029
39PTK21.30572651
40STK391.29138733
41EPHA21.24736018
42CSNK1G11.24392692
43DYRK1B1.22882209
44OXSR11.20968380
45CDC42BPA1.19290961
46MAP2K21.19289940
47MAP3K11.12018590
48LMTK21.09688537
49EIF2AK31.09288392
50SCYL21.07231075
51MET1.06007683
52MAP3K31.03782873
53TNK21.03319949
54SIK10.99826684
55AKT30.98524720
56PAK30.97432054
57UHMK10.97305822
58CSNK1G30.94179955
59PRKCG0.93330290
60PDGFRA0.89699682
61TAOK10.89378355
62PLK20.87504616
63CSNK1G20.86199488
64NTRK30.82382031
65STK160.81919658
66PRKD20.77679563
67YES10.77623667
68PTK2B0.75620458
69STK40.75502535
70BRD40.75490229
71PRKCH0.74620268
72CAMKK20.74298882
73MYLK0.71143031
74MKNK20.69590188
75NLK0.68263552
76FER0.68082707
77STK110.62659107
78ERBB40.62548940
79BMPR20.62203389
80STK38L0.60356534
81MAP2K70.60151039
82ZAK0.59638727
83BMPR1B0.58519942
84PNCK0.56778877
85PRKCE0.55251056
86WNK10.54682825
87ITK0.54661424
88GSK3A0.53817469
89MAPK130.53603082
90CAMK2D0.53495956
91PRKG20.53229529
92JAK20.53087924
93MST1R0.52560563
94LATS10.51097037
95DAPK10.51027693
96PRKCI0.50645761
97TRIB30.49676668
98BRSK20.49676259
99PRKAA10.49633742
100BRAF0.49011890
101MAP2K40.47447119
102MAPKAPK30.45093574
103LIMK10.44988260
104CAMK2A0.42931598
105RPS6KA20.42037479
106CSNK1A1L0.41907438
107TESK10.41387982
108MAP2K10.41238389
109PRKACG0.40539386
110CSK0.40429137
111IRAK20.40158050
112AKT20.38569663
113IRAK40.38449766
114SGK4940.38124811
115SGK2230.38124811
116CSNK1A10.36593260
117STK380.36565773
118SGK20.35301540
119NME10.35032551
120PRKCQ0.34844455
121EPHB10.34669475
122SGK10.34384995
123PRKACB0.34328998
124RET0.33733989
125JAK10.33395151
126ZAP700.33073790
127ERBB30.32948471
128ROCK10.32454431
129MAPK110.32251751
130RPS6KB10.32078723
131EIF2AK10.31805327
132CHUK0.31743102
133CAMK2B0.30080837
134CSNK1D0.29946888
135PRKAA20.29891177
136MTOR0.29888779
137PRKCZ0.29115782
138IGF1R0.28432890
139TNIK0.27711024
140IKBKB0.27305440
141KSR20.25173088
142DYRK1A0.24336637
143TEC0.22961081
144NUAK10.22748815
145CAMK2G0.22419411
146PRKACA0.21494023
147JAK30.21364657
148PRKCA0.19782314
149PRKD10.19248499
150MAPK30.17547128
151SGK30.17341104
152FGFR30.16953027
153DYRK30.13849385
154PRKDC0.13195384
155PRKG10.13189250

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.35307362
2Protein export_Homo sapiens_hsa030604.77155960
3Sulfur metabolism_Homo sapiens_hsa009203.39979643
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.41736055
5Selenocompound metabolism_Homo sapiens_hsa004502.37368116
6Vitamin B6 metabolism_Homo sapiens_hsa007502.28617198
7Tryptophan metabolism_Homo sapiens_hsa003802.25752825
8Insulin secretion_Homo sapiens_hsa049112.20523173
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.06202670
10Folate biosynthesis_Homo sapiens_hsa007901.93749524
11Oxidative phosphorylation_Homo sapiens_hsa001901.75075426
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72117582
13Butanoate metabolism_Homo sapiens_hsa006501.70868442
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69770537
15Fatty acid degradation_Homo sapiens_hsa000711.61909018
16Nitrogen metabolism_Homo sapiens_hsa009101.60626936
17ABC transporters_Homo sapiens_hsa020101.57233119
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.51470948
19Histidine metabolism_Homo sapiens_hsa003401.51151775
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48727861
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45213825
22Fat digestion and absorption_Homo sapiens_hsa049751.43830210
23Starch and sucrose metabolism_Homo sapiens_hsa005001.41195010
24Phenylalanine metabolism_Homo sapiens_hsa003601.40356534
25Type II diabetes mellitus_Homo sapiens_hsa049301.35807196
26Peroxisome_Homo sapiens_hsa041461.29720652
27Vibrio cholerae infection_Homo sapiens_hsa051101.28397891
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27879435
29N-Glycan biosynthesis_Homo sapiens_hsa005101.27256253
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25866273
31Ether lipid metabolism_Homo sapiens_hsa005651.22993249
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21041945
33Arginine biosynthesis_Homo sapiens_hsa002201.19580285
34Type I diabetes mellitus_Homo sapiens_hsa049401.18444855
35Complement and coagulation cascades_Homo sapiens_hsa046101.14287619
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.14115766
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09862113
38Tyrosine metabolism_Homo sapiens_hsa003501.09750398
39Galactose metabolism_Homo sapiens_hsa000521.08380690
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06512973
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.00204782
42Regulation of autophagy_Homo sapiens_hsa041400.99478884
43Fatty acid metabolism_Homo sapiens_hsa012120.97221394
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97201819
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97010363
46Phototransduction_Homo sapiens_hsa047440.94661538
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94450231
48Lysosome_Homo sapiens_hsa041420.93985465
49Circadian rhythm_Homo sapiens_hsa047100.91546634
50Other glycan degradation_Homo sapiens_hsa005110.91483475
51Renin secretion_Homo sapiens_hsa049240.91257476
52Mineral absorption_Homo sapiens_hsa049780.89602335
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89315231
54Serotonergic synapse_Homo sapiens_hsa047260.86862217
55Parkinsons disease_Homo sapiens_hsa050120.86820415
56Glutathione metabolism_Homo sapiens_hsa004800.86722448
57Glucagon signaling pathway_Homo sapiens_hsa049220.86426160
58Arachidonic acid metabolism_Homo sapiens_hsa005900.85989675
59Fatty acid elongation_Homo sapiens_hsa000620.82862929
60Cocaine addiction_Homo sapiens_hsa050300.82797624
61Bile secretion_Homo sapiens_hsa049760.82626827
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81817736
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80064544
64PPAR signaling pathway_Homo sapiens_hsa033200.79628760
65Insulin resistance_Homo sapiens_hsa049310.77233113
66Linoleic acid metabolism_Homo sapiens_hsa005910.75702701
67Alzheimers disease_Homo sapiens_hsa050100.75331348
68Prion diseases_Homo sapiens_hsa050200.74180309
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70226409
70Steroid biosynthesis_Homo sapiens_hsa001000.69471006
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.68177184
72Circadian entrainment_Homo sapiens_hsa047130.68114282
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67942589
74Propanoate metabolism_Homo sapiens_hsa006400.67693724
75Synaptic vesicle cycle_Homo sapiens_hsa047210.66952843
76GABAergic synapse_Homo sapiens_hsa047270.66664674
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65091256
78Chemical carcinogenesis_Homo sapiens_hsa052040.64915679
79beta-Alanine metabolism_Homo sapiens_hsa004100.64801664
80Lysine degradation_Homo sapiens_hsa003100.64073376
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62939889
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61811941
83Dopaminergic synapse_Homo sapiens_hsa047280.60535880
84Thyroid hormone synthesis_Homo sapiens_hsa049180.59794281
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57336864
86Pancreatic secretion_Homo sapiens_hsa049720.56137096
87Pyruvate metabolism_Homo sapiens_hsa006200.56060600
88Vitamin digestion and absorption_Homo sapiens_hsa049770.55974874
89Arginine and proline metabolism_Homo sapiens_hsa003300.55638479
90Caffeine metabolism_Homo sapiens_hsa002320.55218918
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55034011
92Fructose and mannose metabolism_Homo sapiens_hsa000510.52868040
93Retinol metabolism_Homo sapiens_hsa008300.52522760
94Cardiac muscle contraction_Homo sapiens_hsa042600.49703508
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49199911
96Glutamatergic synapse_Homo sapiens_hsa047240.48133268
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46188482
98Long-term depression_Homo sapiens_hsa047300.44814679
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43106852
100Prolactin signaling pathway_Homo sapiens_hsa049170.40970121
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39345902
102Amphetamine addiction_Homo sapiens_hsa050310.38254535
103Metabolic pathways_Homo sapiens_hsa011000.38063953
104Sphingolipid metabolism_Homo sapiens_hsa006000.37177328
105Salivary secretion_Homo sapiens_hsa049700.36968823
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36320133
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34724933
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34256175
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34205650
110Inositol phosphate metabolism_Homo sapiens_hsa005620.33105761
111Huntingtons disease_Homo sapiens_hsa050160.32065367
112Taste transduction_Homo sapiens_hsa047420.31810284
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31767731
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.25084667
115Insulin signaling pathway_Homo sapiens_hsa049100.24916994
116Glycerolipid metabolism_Homo sapiens_hsa005610.23879339
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22525599
118Staphylococcus aureus infection_Homo sapiens_hsa051500.21539622
119Renin-angiotensin system_Homo sapiens_hsa046140.20847009
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.20650867
121Carbon metabolism_Homo sapiens_hsa012000.19884500
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19831484
123Protein digestion and absorption_Homo sapiens_hsa049740.18994563
124AMPK signaling pathway_Homo sapiens_hsa041520.18955879
125Collecting duct acid secretion_Homo sapiens_hsa049660.16886572
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.15705225
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.14541435

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