TM2D3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. Several alternatively spliced transcript variants of this gene are described but the full length nature of some variants has not been determined. Multiple polyadenylation sites have been found in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.27182930
2chaperone-mediated protein transport (GO:0072321)6.00306451
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.89510198
4DNA deamination (GO:0045006)5.85320868
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.44477797
6ATP synthesis coupled proton transport (GO:0015986)5.44477797
7respiratory electron transport chain (GO:0022904)5.35726331
8electron transport chain (GO:0022900)5.24238794
9protein complex biogenesis (GO:0070271)5.02515245
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.97980918
11NADH dehydrogenase complex assembly (GO:0010257)4.97980918
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.97980918
13mitochondrial respiratory chain complex assembly (GO:0033108)4.53914859
14proteasome assembly (GO:0043248)4.35883970
15protein neddylation (GO:0045116)4.30894019
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.27366533
17behavioral response to nicotine (GO:0035095)4.26843752
18respiratory chain complex IV assembly (GO:0008535)4.25797947
19gamma-aminobutyric acid transport (GO:0015812)4.16557031
20inner mitochondrial membrane organization (GO:0007007)4.05926682
21protein deneddylation (GO:0000338)4.01794294
22pyrimidine nucleobase catabolic process (GO:0006208)3.97016268
23maturation of 5.8S rRNA (GO:0000460)3.91031453
24dopamine transport (GO:0015872)3.89183217
257-methylguanosine mRNA capping (GO:0006370)3.87612623
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.80436656
27GTP biosynthetic process (GO:0006183)3.77153130
287-methylguanosine RNA capping (GO:0009452)3.77102874
29RNA capping (GO:0036260)3.77102874
30cytochrome complex assembly (GO:0017004)3.76621826
31positive regulation of mitochondrial fission (GO:0090141)3.68325065
32cullin deneddylation (GO:0010388)3.56630057
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.54391987
34neuronal action potential propagation (GO:0019227)3.53814482
35protein targeting to mitochondrion (GO:0006626)3.53070783
36neuron cell-cell adhesion (GO:0007158)3.52540236
37aerobic respiration (GO:0009060)3.48678086
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43658419
39termination of RNA polymerase III transcription (GO:0006386)3.43092075
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.43092075
41nucleobase catabolic process (GO:0046113)3.42794551
42hydrogen ion transmembrane transport (GO:1902600)3.40791295
43establishment of protein localization to mitochondrion (GO:0072655)3.39761599
44nonmotile primary cilium assembly (GO:0035058)3.39723515
45oxidative phosphorylation (GO:0006119)3.39490423
46guanosine-containing compound biosynthetic process (GO:1901070)3.38678308
47rRNA modification (GO:0000154)3.36319923
48presynaptic membrane assembly (GO:0097105)3.35277496
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33729570
50protein localization to cilium (GO:0061512)3.33333210
51transmission of nerve impulse (GO:0019226)3.33194084
52regulation of cellular amino acid metabolic process (GO:0006521)3.30968638
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29230071
54regulation of mitochondrial translation (GO:0070129)3.28614339
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25909155
56protein localization to mitochondrion (GO:0070585)3.25231932
57L-methionine salvage (GO:0071267)3.24036498
58L-methionine biosynthetic process (GO:0071265)3.24036498
59amino acid salvage (GO:0043102)3.24036498
60ATP hydrolysis coupled proton transport (GO:0015991)3.22376100
61energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.22376100
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22008332
63protein-cofactor linkage (GO:0018065)3.17732188
64synaptic vesicle maturation (GO:0016188)3.16827855
65platelet dense granule organization (GO:0060155)3.16516758
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15253616
67negative regulation of ligase activity (GO:0051352)3.15253616
68iron-sulfur cluster assembly (GO:0016226)3.13914844
69metallo-sulfur cluster assembly (GO:0031163)3.13914844
70detection of light stimulus involved in sensory perception (GO:0050962)3.11068178
71detection of light stimulus involved in visual perception (GO:0050908)3.11068178
72proton transport (GO:0015992)3.10289943
73response to misfolded protein (GO:0051788)3.09900789
74transferrin transport (GO:0033572)3.09761331
75UTP biosynthetic process (GO:0006228)3.08847975
76purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.08668820
77ribosomal small subunit assembly (GO:0000028)3.07223642
78glycosphingolipid biosynthetic process (GO:0006688)3.06971429
79hydrogen transport (GO:0006818)3.05972355
80presynaptic membrane organization (GO:0097090)3.04935974
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04928480
82purine nucleoside triphosphate biosynthetic process (GO:0009145)3.04784027
83behavioral response to ethanol (GO:0048149)3.02662887
84deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.02636643
85positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02399080
86negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00011339
87glutamate receptor signaling pathway (GO:0007215)2.99986486
88ribosomal small subunit biogenesis (GO:0042274)2.98452093
89ionotropic glutamate receptor signaling pathway (GO:0035235)2.97981899
90regulation of cilium movement (GO:0003352)2.97307883
91response to pheromone (GO:0019236)2.96647390
92rRNA methylation (GO:0031167)2.96218698
93neuron-neuron synaptic transmission (GO:0007270)2.95937882
94synaptic transmission, glutamatergic (GO:0035249)2.91608102
95ATP biosynthetic process (GO:0006754)2.89101874
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88814389
97intracellular protein transmembrane import (GO:0044743)2.87821570
98vocalization behavior (GO:0071625)2.87324521
99neurofilament cytoskeleton organization (GO:0060052)2.86756184
100quinone biosynthetic process (GO:1901663)2.85577181
101ubiquinone biosynthetic process (GO:0006744)2.85577181
102cellular ketone body metabolic process (GO:0046950)2.84813683
103NADH metabolic process (GO:0006734)2.84278615
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.83307229
105cellular component biogenesis (GO:0044085)2.83232259
106signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83053397
107signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83053397
108signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83053397
109dendritic spine morphogenesis (GO:0060997)2.82729456
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82263609
111kynurenine metabolic process (GO:0070189)2.82210099
112signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.82153268
113intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.82153268
114regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.81189874
115regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.81189874
116ferric iron transport (GO:0015682)2.79979590
117trivalent inorganic cation transport (GO:0072512)2.79979590
118axoneme assembly (GO:0035082)2.78791679
119startle response (GO:0001964)2.78517883
120ribosomal large subunit biogenesis (GO:0042273)2.78055033
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77602562
122neural tube formation (GO:0001841)2.77377023
123indolalkylamine metabolic process (GO:0006586)2.77128433
124retinal cone cell development (GO:0046549)2.76453966
125anterograde synaptic vesicle transport (GO:0048490)2.76342526
126water-soluble vitamin biosynthetic process (GO:0042364)2.76077840
127neuronal action potential (GO:0019228)2.74332956
128signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73475176
129signal transduction involved in DNA damage checkpoint (GO:0072422)2.73475176
130detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73435624
131CTP metabolic process (GO:0046036)2.73008221
132CTP biosynthetic process (GO:0006241)2.73008221
133positive regulation of ligase activity (GO:0051351)2.72838016
134epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72812572
135piRNA metabolic process (GO:0034587)2.72779522
136establishment of protein localization to Golgi (GO:0072600)2.72441833
137regulation of short-term neuronal synaptic plasticity (GO:0048172)2.72247096
138regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71811310
139ribonucleoside triphosphate biosynthetic process (GO:0009201)2.71329543
140adaptation of signaling pathway (GO:0023058)2.70460737
141regulation of cellular amine metabolic process (GO:0033238)2.69825152
142exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69287334
143indole-containing compound catabolic process (GO:0042436)2.67676227
144indolalkylamine catabolic process (GO:0046218)2.67676227
145tryptophan catabolic process (GO:0006569)2.67676227
146UTP metabolic process (GO:0046051)2.66787559
147signal transduction involved in cell cycle checkpoint (GO:0072395)2.66745935
148reflex (GO:0060004)2.66394982
149regulation of mitochondrial fission (GO:0090140)2.64867830
150protein polyglutamylation (GO:0018095)2.64502028
151protein localization to synapse (GO:0035418)2.63673669
152serotonin metabolic process (GO:0042428)2.63535233
153antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.62143130
154pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.59883235
155cotranslational protein targeting to membrane (GO:0006613)2.59849988
156anterograde axon cargo transport (GO:0008089)2.55806962
157regulation of synapse structural plasticity (GO:0051823)2.55064903
158postsynaptic membrane organization (GO:0001941)2.54134965
159neurotransmitter secretion (GO:0007269)2.54043085
160cilium morphogenesis (GO:0060271)2.53710748
161protein targeting to Golgi (GO:0000042)2.52150126
162regulation of neurotransmitter uptake (GO:0051580)2.50298351
163ketone body metabolic process (GO:1902224)2.49072345
164inositol phosphate catabolic process (GO:0071545)2.46471021
165epithelial cilium movement (GO:0003351)2.46416526
166protein localization to Golgi apparatus (GO:0034067)2.45939446
167indole-containing compound metabolic process (GO:0042430)2.44360315
168DNA double-strand break processing (GO:0000729)2.44309864
169righting reflex (GO:0060013)2.44200441
170photoreceptor cell maintenance (GO:0045494)2.42724447
171gamma-aminobutyric acid signaling pathway (GO:0007214)2.42450134
172membrane depolarization during action potential (GO:0086010)2.41593677
173adult walking behavior (GO:0007628)2.41498434
174brain morphogenesis (GO:0048854)2.41200214
175primary amino compound metabolic process (GO:1901160)2.41051476
176regulation of feeding behavior (GO:0060259)2.40796291
177preassembly of GPI anchor in ER membrane (GO:0016254)2.40414499
178synapse assembly (GO:0007416)2.39744999
179synaptic vesicle exocytosis (GO:0016079)2.39584675
180signal peptide processing (GO:0006465)2.39160226
181synaptic transmission, cholinergic (GO:0007271)2.38352549
182positive regulation of meiosis (GO:0045836)2.38324072
183regulation of action potential (GO:0098900)2.37147135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.84911014
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.98494997
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.97358764
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.92066375
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.89061699
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.78827449
7ZNF274_21170338_ChIP-Seq_K562_Hela3.25023431
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.24544635
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.14830321
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02085857
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.92214798
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.76901296
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70206358
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.67736387
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62710824
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46829753
17* MYC_18555785_ChIP-Seq_MESCs_Mouse2.35071170
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31987941
19* VDR_23849224_ChIP-Seq_CD4+_Human2.28444871
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15113653
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12469350
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11037504
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06125768
24TAF15_26573619_Chip-Seq_HEK293_Human2.05269605
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00235321
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.90356613
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89590903
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83332049
29FOXP3_21729870_ChIP-Seq_TREG_Human1.80741647
30IGF1R_20145208_ChIP-Seq_DFB_Human1.77478246
31* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73233488
32GBX2_23144817_ChIP-Seq_PC3_Human1.73173968
33* GABP_19822575_ChIP-Seq_HepG2_Human1.72782606
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71715611
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.70286000
36SMAD4_21799915_ChIP-Seq_A2780_Human1.68998314
37ER_23166858_ChIP-Seq_MCF-7_Human1.68871597
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68461382
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67158578
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64564489
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60059421
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58794973
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.58446672
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57194368
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55308527
46* DCP1A_22483619_ChIP-Seq_HELA_Human1.54724260
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54093074
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.54082735
49AR_25329375_ChIP-Seq_VCAP_Human1.53549631
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53189131
51* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52700158
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52561706
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.50564748
54ELK1_19687146_ChIP-ChIP_HELA_Human1.50335839
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48304064
56STAT3_23295773_ChIP-Seq_U87_Human1.47746208
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47492951
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47292779
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.46934700
60MYC_18940864_ChIP-ChIP_HL60_Human1.45368654
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45291300
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42998511
63* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42349056
64* CBP_20019798_ChIP-Seq_JUKART_Human1.42349056
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.42138004
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41849425
67* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41241661
68BCAT_22108803_ChIP-Seq_LS180_Human1.40751833
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40305223
70* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.39835747
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38536757
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38372982
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.37576345
74FUS_26573619_Chip-Seq_HEK293_Human1.37027346
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36965420
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36267226
77TCF4_23295773_ChIP-Seq_U87_Human1.35672286
78IRF1_19129219_ChIP-ChIP_H3396_Human1.35589388
79XRN2_22483619_ChIP-Seq_HELA_Human1.34248010
80TTF2_22483619_ChIP-Seq_HELA_Human1.34164354
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.33963364
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32242818
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31825407
84HTT_18923047_ChIP-ChIP_STHdh_Human1.31362450
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31310117
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31310117
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30473286
88RUNX2_22187159_ChIP-Seq_PCA_Human1.28067009
89VDR_22108803_ChIP-Seq_LS180_Human1.27627504
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26338017
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25788342
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23806084
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23532214
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22675959
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22607163
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.22274070
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21846286
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21662423
99ELK1_22589737_ChIP-Seq_MCF10A_Human1.21429841
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21333491
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21236360
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21048695
103TCF4_22108803_ChIP-Seq_LS180_Human1.19967103
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.19544467
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18833158
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.18584425
107NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18513410
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17494037
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17245539
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17060799
111NANOG_19829295_ChIP-Seq_ESCs_Human1.16195000
112SOX2_19829295_ChIP-Seq_ESCs_Human1.16195000
113EZH2_27304074_Chip-Seq_ESCs_Mouse1.16134470
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15721477
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.15720484
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15004187
117JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14554186
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13931741
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.11745817
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10757730
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10313847
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09996905
123FOXA1_25329375_ChIP-Seq_VCAP_Human1.09996905
124P53_22387025_ChIP-Seq_ESCs_Mouse1.09602084
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08668920
126EWS_26573619_Chip-Seq_HEK293_Human1.08643833
127* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07304640
128EZH2_22144423_ChIP-Seq_EOC_Human1.06736092
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05812365
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05412301
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.05148400
132AR_21572438_ChIP-Seq_LNCaP_Human1.04607828
133SOX2_21211035_ChIP-Seq_LN229_Gbm1.03150913
134NOTCH1_21737748_ChIP-Seq_TLL_Human1.02153221
135CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01235604
136* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98707774
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98628667
138ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97775513
139PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97349853
140ERG_20517297_ChIP-Seq_VCAP_Human0.97166339
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96127549
142POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94314215
143CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92808438
144P300_19829295_ChIP-Seq_ESCs_Human0.92407101
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91452366
146IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89071087
147CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88975685
148CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88900370
149LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88625193
150GATA3_21867929_ChIP-Seq_TH1_Mouse0.88172610
151* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84425440
152TAL1_26923725_Chip-Seq_HPCs_Mouse0.84376606
153TP53_22573176_ChIP-Seq_HFKS_Human0.84063447
154NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84046173
155CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82827641
156REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82235111
157RNF2_27304074_Chip-Seq_NSC_Mouse0.81129787
158RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80150058
159MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79749905
160CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78244590
161JUN_21703547_ChIP-Seq_K562_Human0.78019213
162REST_21632747_ChIP-Seq_MESCs_Mouse0.77622416
163E2F4_17652178_ChIP-ChIP_JURKAT_Human0.75368681

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization4.13818372
2MP0003880_abnormal_central_pattern3.63423594
3MP0001905_abnormal_dopamine_level3.22624944
4MP0003787_abnormal_imprinting2.95722199
5MP0005451_abnormal_body_composition2.78072049
6MP0002736_abnormal_nociception_after2.72553356
7MP0006276_abnormal_autonomic_nervous2.66303015
8MP0003718_maternal_effect2.59546333
9MP0005646_abnormal_pituitary_gland2.53089962
10MP0002876_abnormal_thyroid_physiology2.49595156
11MP0000569_abnormal_digit_pigmentation2.33675119
12MP0001968_abnormal_touch/_nociception2.24030965
13MP0003195_calcinosis2.21755530
14MP0004270_analgesia2.09820149
15MP0010386_abnormal_urinary_bladder2.07003759
16MP0001986_abnormal_taste_sensitivity2.02706519
17MP0001188_hyperpigmentation2.00841201
18MP0003646_muscle_fatigue1.91471737
19MP0009379_abnormal_foot_pigmentation1.90776392
20MP0006036_abnormal_mitochondrial_physio1.90085161
21MP0002102_abnormal_ear_morphology1.85984013
22MP0005379_endocrine/exocrine_gland_phen1.84434767
23MP0009745_abnormal_behavioral_response1.78631156
24MP0003693_abnormal_embryo_hatching1.77933691
25MP0004142_abnormal_muscle_tone1.77405597
26MP0006292_abnormal_olfactory_placode1.71729546
27MP0008877_abnormal_DNA_methylation1.71179413
28MP0001501_abnormal_sleep_pattern1.70376961
29MP0002064_seizures1.69531161
30MP0002272_abnormal_nervous_system1.66285595
31MP0003123_paternal_imprinting1.65814685
32MP0009046_muscle_twitch1.64725022
33MP0004957_abnormal_blastocyst_morpholog1.61006558
34MP0002572_abnormal_emotion/affect_behav1.59311757
35MP0003635_abnormal_synaptic_transmissio1.59157685
36MP0002734_abnormal_mechanical_nocicepti1.58806000
37MP0002837_dystrophic_cardiac_calcinosis1.57749009
38MP0006035_abnormal_mitochondrial_morpho1.57100990
39MP0000778_abnormal_nervous_system1.51721504
40MP0008872_abnormal_physiological_respon1.49804174
41MP0009697_abnormal_copulation1.49730780
42MP0002638_abnormal_pupillary_reflex1.49560162
43MP0002163_abnormal_gland_morphology1.49441877
44MP0004885_abnormal_endolymph1.44959478
45MP0005253_abnormal_eye_physiology1.44747249
46MP0003186_abnormal_redox_activity1.43103629
47MP0001764_abnormal_homeostasis1.40660402
48MP0001984_abnormal_olfaction1.40646806
49MP0002909_abnormal_adrenal_gland1.40026740
50MP0004924_abnormal_behavior1.37322821
51MP0005386_behavior/neurological_phenoty1.37322821
52MP0005084_abnormal_gallbladder_morpholo1.35158330
53MP0003122_maternal_imprinting1.32324440
54MP0003879_abnormal_hair_cell1.31869236
55MP0001440_abnormal_grooming_behavior1.30665146
56MP0002735_abnormal_chemical_nociception1.27795335
57MP0002067_abnormal_sensory_capabilities1.27493182
58MP0005423_abnormal_somatic_nervous1.26992989
59MP0001970_abnormal_pain_threshold1.26939126
60MP0000427_abnormal_hair_cycle1.24542731
61MP0004742_abnormal_vestibular_system1.19594047
62MP0002733_abnormal_thermal_nociception1.17630388
63MP0003011_delayed_dark_adaptation1.16930990
64MP0002063_abnormal_learning/memory/cond1.15774816
65MP0005636_abnormal_mineral_homeostasis1.14992546
66MP0005310_abnormal_salivary_gland1.14347566
67MP0004147_increased_porphyrin_level1.10772642
68MP0002184_abnormal_innervation1.09443977
69MP0001502_abnormal_circadian_rhythm1.09409825
70MP0002229_neurodegeneration1.08535801
71MP0006072_abnormal_retinal_apoptosis1.07920123
72MP0002277_abnormal_respiratory_mucosa1.07627261
73MP0005408_hypopigmentation1.07352966
74MP0003633_abnormal_nervous_system1.07107216
75MP0005551_abnormal_eye_electrophysiolog1.06627947
76MP0002928_abnormal_bile_duct1.06587620
77MP0002332_abnormal_exercise_endurance1.06142351
78MP0002882_abnormal_neuron_morphology1.05955315
79MP0003724_increased_susceptibility_to1.04530579
80MP0000955_abnormal_spinal_cord1.04426139
81MP0004859_abnormal_synaptic_plasticity1.03826906
82MP0010094_abnormal_chromosome_stability1.01430337
83MP0004811_abnormal_neuron_physiology0.99432901
84MP0000538_abnormal_urinary_bladder0.99207569
85MP0008932_abnormal_embryonic_tissue0.97340952
86MP0008058_abnormal_DNA_repair0.97014207
87MP0008057_abnormal_DNA_replication0.95812999
88MP0003786_premature_aging0.95293844
89MP0005645_abnormal_hypothalamus_physiol0.95267496
90MP0002066_abnormal_motor_capabilities/c0.94805872
91MP0008875_abnormal_xenobiotic_pharmacok0.94455833
92MP0002752_abnormal_somatic_nervous0.94290765
93MP0000639_abnormal_adrenal_gland0.94052661
94MP0002557_abnormal_social/conspecific_i0.94035359
95MP0000681_abnormal_thyroid_gland0.92704686
96MP0003868_abnormal_feces_composition0.91122078
97MP0008260_abnormal_autophagy0.90755747
98MP0003315_abnormal_perineum_morphology0.90244042
99MP0001119_abnormal_female_reproductive0.90218062
100MP0008995_early_reproductive_senescence0.89837506
101MP0001486_abnormal_startle_reflex0.89494406
102MP0001485_abnormal_pinna_reflex0.88302318
103MP0000631_abnormal_neuroendocrine_gland0.87234869
104MP0004782_abnormal_surfactant_physiolog0.87155175
105MP0001929_abnormal_gametogenesis0.87063260
106MP0001664_abnormal_digestion0.86672826
107MP0002139_abnormal_hepatobiliary_system0.86565976
108MP0004043_abnormal_pH_regulation0.85707999
109MP0005671_abnormal_response_to0.84566034
110MP0003631_nervous_system_phenotype0.83475143
111MP0008569_lethality_at_weaning0.83426121
112MP0003121_genomic_imprinting0.83098931
113MP0004215_abnormal_myocardial_fiber0.82878325
114MP0002090_abnormal_vision0.82540063
115MP0005266_abnormal_metabolism0.81693413
116MP0000372_irregular_coat_pigmentation0.81353381
117MP0002069_abnormal_eating/drinking_beha0.79027082
118MP0005395_other_phenotype0.79024287
119MP0002822_catalepsy0.78747410
120MP0000013_abnormal_adipose_tissue0.78524770
121MP0004133_heterotaxia0.78104121
122MP0000230_abnormal_systemic_arterial0.78076626
123MP0003698_abnormal_male_reproductive0.77053146
124MP0002160_abnormal_reproductive_system0.76345101
125MP0005389_reproductive_system_phenotype0.75961082
126MP0005376_homeostasis/metabolism_phenot0.75483123
127MP0002653_abnormal_ependyma_morphology0.75259640
128MP0005332_abnormal_amino_acid0.74922239
129MP0001963_abnormal_hearing_physiology0.74907255
130MP0009333_abnormal_splenocyte_physiolog0.74750290
131MP0005058_abnormal_lysosome_morphology0.74683784
132MP0005367_renal/urinary_system_phenotyp0.73886942
133MP0000516_abnormal_urinary_system0.73886942
134MP0003077_abnormal_cell_cycle0.73666504
135MP0005499_abnormal_olfactory_system0.73448144
136MP0005394_taste/olfaction_phenotype0.73448144
137MP0000653_abnormal_sex_gland0.73214998
138MP0005535_abnormal_body_temperature0.72602900
139MP0000026_abnormal_inner_ear0.72587034
140MP0002751_abnormal_autonomic_nervous0.72497907
141MP0005195_abnormal_posterior_eye0.71658791
142MP0004145_abnormal_muscle_electrophysio0.71415321

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.32454749
2Abnormal mitochondria in muscle tissue (HP:0008316)5.90723067
3Mitochondrial inheritance (HP:0001427)5.54334242
4Acute encephalopathy (HP:0006846)5.25466926
5Progressive macrocephaly (HP:0004481)5.19514551
6Increased CSF lactate (HP:0002490)5.12267287
7Hepatocellular necrosis (HP:0001404)4.95675100
8Hepatic necrosis (HP:0002605)4.37969418
9Increased hepatocellular lipid droplets (HP:0006565)4.28732788
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.14383001
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.14383001
12Lipid accumulation in hepatocytes (HP:0006561)3.79225684
13Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.70906955
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.65064459
15Renal Fanconi syndrome (HP:0001994)3.62919500
16Lactic acidosis (HP:0003128)3.54752138
17Increased intramyocellular lipid droplets (HP:0012240)3.54514809
18Cerebral edema (HP:0002181)3.50904671
19Increased serum lactate (HP:0002151)3.43280945
203-Methylglutaconic aciduria (HP:0003535)3.31763855
21Exercise intolerance (HP:0003546)3.26891716
22Respiratory failure (HP:0002878)3.20007472
23Optic disc pallor (HP:0000543)3.15123952
24Gaze-evoked nystagmus (HP:0000640)3.13284137
25Exertional dyspnea (HP:0002875)3.11719699
26Hypothermia (HP:0002045)3.05301362
27Nephronophthisis (HP:0000090)2.96668535
28Increased muscle lipid content (HP:0009058)2.90559393
29Respiratory difficulties (HP:0002880)2.87726832
30Focal seizures (HP:0007359)2.86810822
31Congenital stationary night blindness (HP:0007642)2.82016604
32Pancreatic fibrosis (HP:0100732)2.78412085
33Abnormal hair whorl (HP:0010721)2.74465016
34Progressive cerebellar ataxia (HP:0002073)2.71534508
35Medial flaring of the eyebrow (HP:0010747)2.70417479
36Leukodystrophy (HP:0002415)2.70367879
37Abnormality of the labia minora (HP:0012880)2.69425856
38Congenital primary aphakia (HP:0007707)2.63860497
39Focal motor seizures (HP:0011153)2.63607442
40Abnormality of glycolysis (HP:0004366)2.61145521
41Increased serum pyruvate (HP:0003542)2.61145521
42Poor suck (HP:0002033)2.60814857
43Dialeptic seizures (HP:0011146)2.60350573
44Gait imbalance (HP:0002141)2.59804259
45Nephrogenic diabetes insipidus (HP:0009806)2.58098741
46CNS demyelination (HP:0007305)2.52632173
47Abnormality of renal resorption (HP:0011038)2.50237231
48Broad-based gait (HP:0002136)2.49119577
49Microvesicular hepatic steatosis (HP:0001414)2.48848930
50Progressive inability to walk (HP:0002505)2.47880560
51Abnormality of the renal medulla (HP:0100957)2.47358448
52Inability to walk (HP:0002540)2.47125586
53Type I transferrin isoform profile (HP:0003642)2.42345491
54Abnormality of the renal cortex (HP:0011035)2.41838893
55Abnormality of cells of the erythroid lineage (HP:0012130)2.39699954
56Myokymia (HP:0002411)2.38002215
57Birth length less than 3rd percentile (HP:0003561)2.37989359
58Abnormal number of erythroid precursors (HP:0012131)2.37556555
59Amyotrophic lateral sclerosis (HP:0007354)2.36405914
60Emotional lability (HP:0000712)2.35166310
61Type II lissencephaly (HP:0007260)2.32526170
62Unsteady gait (HP:0002317)2.32525514
63Lethargy (HP:0001254)2.31176897
64Absence seizures (HP:0002121)2.31090267
65Hemiparesis (HP:0001269)2.29399327
66Poor coordination (HP:0002370)2.29205465
67Lissencephaly (HP:0001339)2.27945933
68Abnormality of urine glucose concentration (HP:0011016)2.27201591
69Glycosuria (HP:0003076)2.27201591
70Pancreatic cysts (HP:0001737)2.23812479
71Atonic seizures (HP:0010819)2.21525375
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21471892
73Abnormality of alanine metabolism (HP:0010916)2.21471892
74Hyperalaninemia (HP:0003348)2.21471892
75True hermaphroditism (HP:0010459)2.19963963
76Renal cortical cysts (HP:0000803)2.18466929
77Abolished electroretinogram (ERG) (HP:0000550)2.17875664
78Absent speech (HP:0001344)2.15610296
79Methylmalonic acidemia (HP:0002912)2.15415484
80Aplasia/hypoplasia of the uterus (HP:0008684)2.14021363
81Epileptiform EEG discharges (HP:0011182)2.13524273
82Drooling (HP:0002307)2.13333525
83Hypsarrhythmia (HP:0002521)2.13233916
84Cystic liver disease (HP:0006706)2.12539213
85Generalized tonic-clonic seizures (HP:0002069)2.11462939
86Oligomenorrhea (HP:0000876)2.11226997
87EEG with generalized epileptiform discharges (HP:0011198)2.10685778
88Abnormal pupillary function (HP:0007686)2.09985015
89Pachygyria (HP:0001302)2.04914018
90Limb dystonia (HP:0002451)2.03925760
91Hyperphosphaturia (HP:0003109)2.03036960
92Macrocytic anemia (HP:0001972)2.02769919
93Aplastic anemia (HP:0001915)2.02724692
94Specific learning disability (HP:0001328)2.01888913
95Breast hypoplasia (HP:0003187)2.01829032
96Agitation (HP:0000713)2.01586273
97Large for gestational age (HP:0001520)2.01413110
98Polydipsia (HP:0001959)2.01270394
99Abnormal drinking behavior (HP:0030082)2.01270394
100Methylmalonic aciduria (HP:0012120)2.00623882
101Attenuation of retinal blood vessels (HP:0007843)2.00430777
102Abnormal biliary tract physiology (HP:0012439)2.00141935
103Bile duct proliferation (HP:0001408)2.00141935
104Neuroendocrine neoplasm (HP:0100634)2.00018611
105Intestinal atresia (HP:0011100)1.98279121
106Chronic hepatic failure (HP:0100626)1.98147334
107Gliosis (HP:0002171)1.96393235
108Ketoacidosis (HP:0001993)1.95874762
109Excessive salivation (HP:0003781)1.95539064
110CNS hypomyelination (HP:0003429)1.94543535
111Abnormal eating behavior (HP:0100738)1.93944901
112Delusions (HP:0000746)1.93050190
113Abnormal rod and cone electroretinograms (HP:0008323)1.91821412
114Mutism (HP:0002300)1.91156178
115X-linked dominant inheritance (HP:0001423)1.90666311
116Dyskinesia (HP:0100660)1.86029958
117Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83014889
118Degeneration of the lateral corticospinal tracts (HP:0002314)1.83014889
119Amniotic constriction ring (HP:0009775)1.83013783
120Abnormality of placental membranes (HP:0011409)1.83013783
121Sclerocornea (HP:0000647)1.82922627
122Postaxial hand polydactyly (HP:0001162)1.82539896
123Abnormality of macular pigmentation (HP:0008002)1.82024543
124Hyperventilation (HP:0002883)1.80273524
125Atrophy/Degeneration involving motor neurons (HP:0007373)1.80126717
126Hypoplasia of the uterus (HP:0000013)1.79963225
127Polyphagia (HP:0002591)1.78870034
128Hyperglycinemia (HP:0002154)1.76929871
129Vaginal atresia (HP:0000148)1.76670147
130Genetic anticipation (HP:0003743)1.76282872
131Retinal dysplasia (HP:0007973)1.75498808
132Male pseudohermaphroditism (HP:0000037)1.75162531
133Genital tract atresia (HP:0001827)1.75115541
134Anencephaly (HP:0002323)1.74933439
135Cerebral hypomyelination (HP:0006808)1.74747855
136Abnormal glycosylation (HP:0012345)1.73808145
137Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73808145
138Abnormal protein N-linked glycosylation (HP:0012347)1.73808145
139Abnormal protein glycosylation (HP:0012346)1.73808145
140Pheochromocytoma (HP:0002666)1.73013245
141Spastic tetraplegia (HP:0002510)1.71671034
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.70252583
143Optic nerve hypoplasia (HP:0000609)1.69095737
144Aplasia/Hypoplasia of the lens (HP:0008063)1.69018704
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.67663641
146Type 2 muscle fiber atrophy (HP:0003554)1.66725112
147Narrow forehead (HP:0000341)1.66466599
148Febrile seizures (HP:0002373)1.66105776
149Ketosis (HP:0001946)1.65278877
150Generalized aminoaciduria (HP:0002909)1.64987023
151Renal tubular dysfunction (HP:0000124)1.64055066
152Abnormality of the axillary hair (HP:0100134)1.63492024
153Abnormality of secondary sexual hair (HP:0009888)1.63492024
154Epileptic encephalopathy (HP:0200134)1.61101547
155Secondary amenorrhea (HP:0000869)1.59563702
156Pallor (HP:0000980)1.58855512
157Reticulocytopenia (HP:0001896)1.58526603
158Abnormality of midbrain morphology (HP:0002418)1.58440050
159Molar tooth sign on MRI (HP:0002419)1.58440050
160Carpal bone hypoplasia (HP:0001498)1.57726831
161Premature ovarian failure (HP:0008209)1.57657725
162Cholecystitis (HP:0001082)1.57253335
163Abnormal gallbladder physiology (HP:0012438)1.57253335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.63358233
2MAP3K123.99994756
3MAP2K73.25768765
4CASK3.25187312
5BUB13.20473450
6MARK12.68111942
7MAP4K22.67402980
8MUSK2.57123823
9STK162.47654401
10NME12.34404864
11ARAF2.27805133
12MAP3K42.19887389
13CDK82.02146481
14TSSK61.98621598
15TRIM281.96783767
16BRAF1.93296388
17NUAK11.93207777
18PLK41.92554378
19TNIK1.86313104
20VRK11.77236403
21BMPR21.76885881
22WEE11.75563908
23AKT31.74497684
24NME21.67273157
25CDK191.64994536
26GRK71.63422802
27ERBB41.56262424
28ADRBK21.55416911
29DAPK21.55085007
30EIF2AK31.52824670
31PAK31.52289684
32CCNB11.48708463
33MAP3K61.48579923
34ACVR1B1.43405299
35GRK51.43119819
36BCKDK1.40945261
37BMPR1B1.38942471
38MOS1.36809407
39MYLK1.36457903
40NTRK21.32171063
41SRPK11.30754140
42STK38L1.30304727
43IRAK31.29006292
44TAOK31.23494393
45MAP2K41.20802174
46ERBB31.18342107
47MAPKAPK51.16271229
48PHKG21.13967321
49PHKG11.13967321
50NTRK31.12578411
51FGFR21.11222457
52CSNK1A1L1.10798397
53PRKCE1.08190642
54EPHA31.07558302
55MINK11.05896118
56MAPK131.03867825
57PLK21.00626157
58BRSK20.98909405
59MST40.96266746
60EIF2AK10.94377395
61SIK20.94035287
62KIT0.93811416
63DAPK10.93386084
64OXSR10.92148347
65PLK10.91141140
66INSRR0.91104724
67CSNK1G30.89140049
68RAF10.86756611
69PLK30.85614427
70DYRK20.84477014
71TLK10.84217653
72CAMK2A0.79474416
73CDK30.77360106
74PINK10.74548587
75SIK30.73540626
76AURKA0.71017045
77MAP3K130.68748224
78PNCK0.68143989
79WNK30.68048449
80TEC0.67907771
81CSNK1G10.65847171
82EPHA40.65794181
83CDK50.65197966
84STK390.64973430
85MAP3K90.64726639
86ZAK0.64552030
87PRKCG0.64219380
88PBK0.64075911
89PKN10.63908447
90CSNK1G20.63700627
91UHMK10.62878960
92DYRK1A0.62808468
93ADRBK10.62686938
94IRAK40.62088853
95BRSK10.62012815
96PAK60.62001776
97ABL20.57397233
98PIM20.56249115
99CSNK2A10.54513484
100CAMK2G0.53915786
101TTK0.53611285
102PDK30.51780400
103PDK40.51780400
104PRKCQ0.51590696
105CAMK10.50922186
106GRK10.50527458
107CHEK20.50512641
108STK110.49909612
109PRKCZ0.48070792
110PDK20.47957357
111TXK0.47515991
112LIMK10.47373583
113TYK20.46867009
114MAP2K60.46166706
115RPS6KA50.46006142
116SGK20.45717779
117CAMK2B0.45116791
118LATS20.44049022
119SGK2230.43580386
120SGK4940.43580386
121CSNK2A20.42955021
122CSNK1D0.41619735
123PIK3CA0.41176558
124CSNK1A10.40987897
125IRAK10.40519118
126BCR0.39661962
127TNK20.39352747
128CAMKK20.38909586
129MAPKAPK30.38697012
130PTK2B0.37567935
131PRKAA10.37390301
132RIPK40.37339783
133NEK60.37337938
134CAMKK10.37195607
135BRD40.37151214
136PRKG10.35903695
137SYK0.35319195
138PRKCI0.34980622
139CDC70.33277199
140MKNK20.32696645
141IKBKE0.32543422
142WNK40.32154638
143PRKACA0.30530817
144CAMK2D0.30219113
145PRKCA0.29908324
146CAMK40.29899988
147PRKACB0.28005605
148FES0.27953555
149AURKB0.27638766

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.32771941
2Parkinsons disease_Homo sapiens_hsa050124.28871751
3Proteasome_Homo sapiens_hsa030503.64163119
4RNA polymerase_Homo sapiens_hsa030203.27320741
5Huntingtons disease_Homo sapiens_hsa050163.25094654
6Ribosome_Homo sapiens_hsa030103.11760959
7Alzheimers disease_Homo sapiens_hsa050103.11178125
8Protein export_Homo sapiens_hsa030603.10020838
9Collecting duct acid secretion_Homo sapiens_hsa049662.77143210
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.47319423
11Nicotine addiction_Homo sapiens_hsa050331.98468541
12Pyrimidine metabolism_Homo sapiens_hsa002401.95948438
13Synaptic vesicle cycle_Homo sapiens_hsa047211.70050639
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63554915
15Circadian entrainment_Homo sapiens_hsa047131.62805765
16Basal transcription factors_Homo sapiens_hsa030221.61394948
17Nitrogen metabolism_Homo sapiens_hsa009101.60921441
18Vibrio cholerae infection_Homo sapiens_hsa051101.56335655
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.50427904
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49071649
21RNA degradation_Homo sapiens_hsa030181.48295235
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46029190
23Vitamin B6 metabolism_Homo sapiens_hsa007501.38988509
24Purine metabolism_Homo sapiens_hsa002301.37987171
25Cardiac muscle contraction_Homo sapiens_hsa042601.37799319
26Dopaminergic synapse_Homo sapiens_hsa047281.36698260
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35788430
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35745056
29Homologous recombination_Homo sapiens_hsa034401.30473425
30Olfactory transduction_Homo sapiens_hsa047401.24012127
31Tryptophan metabolism_Homo sapiens_hsa003801.23135133
32DNA replication_Homo sapiens_hsa030301.22139099
33Nucleotide excision repair_Homo sapiens_hsa034201.21638996
34Rheumatoid arthritis_Homo sapiens_hsa053231.17301403
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13687569
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.12019807
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09094696
38Mismatch repair_Homo sapiens_hsa034301.08566996
39Caffeine metabolism_Homo sapiens_hsa002321.08511098
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07102179
41Pyruvate metabolism_Homo sapiens_hsa006201.04873481
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04537423
43Selenocompound metabolism_Homo sapiens_hsa004501.01222285
44Phototransduction_Homo sapiens_hsa047440.99341435
45Base excision repair_Homo sapiens_hsa034100.98591908
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.98561559
47Folate biosynthesis_Homo sapiens_hsa007900.98163334
48Fatty acid elongation_Homo sapiens_hsa000620.92787792
49Metabolic pathways_Homo sapiens_hsa011000.92734307
50Spliceosome_Homo sapiens_hsa030400.90043774
51Long-term depression_Homo sapiens_hsa047300.89029118
52Salivary secretion_Homo sapiens_hsa049700.88576481
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87380292
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85660467
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85215941
56Steroid biosynthesis_Homo sapiens_hsa001000.84095634
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83877160
58Fructose and mannose metabolism_Homo sapiens_hsa000510.82571900
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82439577
60Regulation of autophagy_Homo sapiens_hsa041400.80490370
61Taste transduction_Homo sapiens_hsa047420.80206543
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80063550
63beta-Alanine metabolism_Homo sapiens_hsa004100.79811759
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.78107195
65RNA transport_Homo sapiens_hsa030130.75595095
66GABAergic synapse_Homo sapiens_hsa047270.73025357
67Cell cycle_Homo sapiens_hsa041100.72809875
68ABC transporters_Homo sapiens_hsa020100.71998612
69Glutathione metabolism_Homo sapiens_hsa004800.71695959
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70129633
71Arachidonic acid metabolism_Homo sapiens_hsa005900.69479755
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68930759
73Serotonergic synapse_Homo sapiens_hsa047260.68650722
74Pentose phosphate pathway_Homo sapiens_hsa000300.67591994
75Renin secretion_Homo sapiens_hsa049240.64747543
76Linoleic acid metabolism_Homo sapiens_hsa005910.64213316
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.63429032
78Amphetamine addiction_Homo sapiens_hsa050310.63370967
79Cholinergic synapse_Homo sapiens_hsa047250.62160873
80Type I diabetes mellitus_Homo sapiens_hsa049400.61501789
81Cocaine addiction_Homo sapiens_hsa050300.61227596
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.60703061
83Other glycan degradation_Homo sapiens_hsa005110.60181073
84Fanconi anemia pathway_Homo sapiens_hsa034600.57631020
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57172315
86Ether lipid metabolism_Homo sapiens_hsa005650.56656002
87Gastric acid secretion_Homo sapiens_hsa049710.55748313
88Sulfur relay system_Homo sapiens_hsa041220.55696042
89Sulfur metabolism_Homo sapiens_hsa009200.55630931
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52741847
91cAMP signaling pathway_Homo sapiens_hsa040240.52343980
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50787013
93Retinol metabolism_Homo sapiens_hsa008300.50423910
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.49917897
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49490672
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48951933
97Oxytocin signaling pathway_Homo sapiens_hsa049210.48658362
98Peroxisome_Homo sapiens_hsa041460.47942156
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47171551
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46744383
101Non-homologous end-joining_Homo sapiens_hsa034500.45001404
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44822926
103Morphine addiction_Homo sapiens_hsa050320.43104474
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42975394
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42971025
106Tyrosine metabolism_Homo sapiens_hsa003500.42428016
107Carbon metabolism_Homo sapiens_hsa012000.42425248
108Circadian rhythm_Homo sapiens_hsa047100.41589074
109Oocyte meiosis_Homo sapiens_hsa041140.40515882
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39928330
111Galactose metabolism_Homo sapiens_hsa000520.39271629
112Phagosome_Homo sapiens_hsa041450.37329521
113Dorso-ventral axis formation_Homo sapiens_hsa043200.37281171
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.36972932
115Biosynthesis of amino acids_Homo sapiens_hsa012300.36798060
116Chemical carcinogenesis_Homo sapiens_hsa052040.36599496
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36585227
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36062724
119Phenylalanine metabolism_Homo sapiens_hsa003600.36009166
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35459139
121N-Glycan biosynthesis_Homo sapiens_hsa005100.34540523
122Propanoate metabolism_Homo sapiens_hsa006400.32690298
123Fatty acid metabolism_Homo sapiens_hsa012120.31507436
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31056006
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30769120
126Glutamatergic synapse_Homo sapiens_hsa047240.28518917
127Type II diabetes mellitus_Homo sapiens_hsa049300.28501799
128Calcium signaling pathway_Homo sapiens_hsa040200.28476588
129Pancreatic secretion_Homo sapiens_hsa049720.28041573
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27938622
131Ovarian steroidogenesis_Homo sapiens_hsa049130.26143204
132Insulin secretion_Homo sapiens_hsa049110.26125202
133Epstein-Barr virus infection_Homo sapiens_hsa051690.24572946
134Histidine metabolism_Homo sapiens_hsa003400.24495454
135Sphingolipid metabolism_Homo sapiens_hsa006000.24183190
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22908918
137Allograft rejection_Homo sapiens_hsa053300.22464034
138Butanoate metabolism_Homo sapiens_hsa006500.21277177

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