TLX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)8.62447648
2proline metabolic process (GO:0006560)8.51994351
3embryonic process involved in female pregnancy (GO:0060136)8.05816399
4replication fork processing (GO:0031297)7.63800033
5positive regulation of protein homooligomerization (GO:0032464)7.24386852
6oxidative demethylation (GO:0070989)6.67202782
7establishment of apical/basal cell polarity (GO:0035089)6.59307880
8regulation of integrin activation (GO:0033623)6.53812258
9regulation of protein homooligomerization (GO:0032462)6.36459893
10DNA deamination (GO:0045006)6.30587753
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.06290046
12establishment of monopolar cell polarity (GO:0061162)5.98160648
13establishment or maintenance of monopolar cell polarity (GO:0061339)5.98160648
14cellular response to ATP (GO:0071318)5.43961701
15mitochondrial DNA metabolic process (GO:0032042)5.38129787
16DNA strand renaturation (GO:0000733)5.32278560
17somatic hypermutation of immunoglobulin genes (GO:0016446)5.26088856
18somatic diversification of immune receptors via somatic mutation (GO:0002566)5.26088856
19mitotic G1 DNA damage checkpoint (GO:0031571)5.25353994
20poly(A)+ mRNA export from nucleus (GO:0016973)5.18643678
21negative regulation of JAK-STAT cascade (GO:0046426)5.16159798
22histone arginine methylation (GO:0034969)5.07489063
23peripheral nervous system neuron development (GO:0048935)4.92768663
24negative regulation of Ras GTPase activity (GO:0034261)4.78077229
25lymph vessel development (GO:0001945)4.69630228
26embryonic placenta development (GO:0001892)4.69371867
27G1 DNA damage checkpoint (GO:0044783)4.69241429
28negative regulation of protein oligomerization (GO:0032460)4.66205108
29mitotic G1/S transition checkpoint (GO:0044819)4.64594102
30viral mRNA export from host cell nucleus (GO:0046784)4.61352758
31glutamine family amino acid biosynthetic process (GO:0009084)4.55707078
32mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.44337184
33negative regulation of cell cycle arrest (GO:0071157)4.43827238
34muscle cell fate commitment (GO:0042693)4.42579356
35regulation of translational fidelity (GO:0006450)4.40128119
36establishment of protein localization to mitochondrial membrane (GO:0090151)4.40043832
37negative regulation of fatty acid biosynthetic process (GO:0045717)4.40005317
38cranial nerve morphogenesis (GO:0021602)4.22727357
39DNA integration (GO:0015074)4.18752852
40negative regulation of heart rate (GO:0010459)4.17943665
41mRNA cleavage (GO:0006379)4.16811815
42convergent extension (GO:0060026)4.14723899
43skeletal muscle organ development (GO:0060538)4.12678453
44negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.10557767
45thyroid gland development (GO:0030878)4.09696810
46positive regulation of developmental pigmentation (GO:0048087)4.08298173
47regulation of cAMP-dependent protein kinase activity (GO:2000479)4.07494970
48spliceosomal tri-snRNP complex assembly (GO:0000244)4.07323840
49regulation of protein oligomerization (GO:0032459)4.07160947
50heterochromatin organization (GO:0070828)4.00064732
51positive regulation of protein oligomerization (GO:0032461)3.99331193
52regulation of mammary gland epithelial cell proliferation (GO:0033599)3.97035647
53cellular response to zinc ion (GO:0071294)3.94952291
54glial cell migration (GO:0008347)3.93707210
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.91974141
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.91974141
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.91974141
58face development (GO:0060324)3.89312589
59outer ear morphogenesis (GO:0042473)3.87884563
60base-excision repair (GO:0006284)3.87603701
61embryonic camera-type eye development (GO:0031076)3.78721665
62positive regulation by host of viral transcription (GO:0043923)3.76689036
63labyrinthine layer development (GO:0060711)3.72715852
64diaphragm development (GO:0060539)3.72052627
65ribosomal small subunit biogenesis (GO:0042274)3.71287030
66regulation of mesenchymal cell apoptotic process (GO:2001053)3.70867898
67negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.69951249
68double-strand break repair via nonhomologous end joining (GO:0006303)3.67985319
69non-recombinational repair (GO:0000726)3.67985319
70dosage compensation (GO:0007549)3.67644555
71muscle organ morphogenesis (GO:0048644)3.66405307
72cell migration in hindbrain (GO:0021535)3.64842368
73DNA double-strand break processing (GO:0000729)3.64099321
74mesenchymal to epithelial transition (GO:0060231)3.64099212
75establishment of mitochondrion localization (GO:0051654)3.63823781
76regulation of RNA export from nucleus (GO:0046831)3.63635410
77negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.63387841
78cerebellar granule cell differentiation (GO:0021707)3.60157561
79embryonic heart tube development (GO:0035050)3.57745751
80peptidyl-arginine omega-N-methylation (GO:0035247)3.56740821
81base-excision repair, AP site formation (GO:0006285)3.53459486
82formation of translation preinitiation complex (GO:0001731)3.52637922
83regulation of chromatin binding (GO:0035561)3.49244185
84histone H4-K12 acetylation (GO:0043983)3.48854089
85positive regulation of DNA repair (GO:0045739)3.47702090
86regulation of apoptotic process involved in morphogenesis (GO:1902337)3.46432455
87pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45874071
88protein targeting to vacuole (GO:0006623)3.44156488
89protein targeting to lysosome (GO:0006622)3.44156488
90establishment of protein localization to vacuole (GO:0072666)3.44156488
91negative regulation of organelle assembly (GO:1902116)3.42753450
92mitochondrial RNA metabolic process (GO:0000959)3.42456363
93anatomical structure regression (GO:0060033)3.42041044
94regulation of cell size (GO:0008361)3.40906716
95GDP-mannose metabolic process (GO:0019673)3.39870405
96signal complex assembly (GO:0007172)3.39073650
97tooth mineralization (GO:0034505)3.37086166
98apoptotic process involved in morphogenesis (GO:0060561)3.33374049
99trophectodermal cell differentiation (GO:0001829)3.32558929
100auditory receptor cell stereocilium organization (GO:0060088)3.31845790
101DNA ligation (GO:0006266)3.31147509
102regulation of mitochondrial depolarization (GO:0051900)3.30052705
103negative regulation of mRNA processing (GO:0050686)3.29714599
104regulation of sister chromatid cohesion (GO:0007063)3.29633834
105body morphogenesis (GO:0010171)3.27911285
106mitochondrion transport along microtubule (GO:0047497)3.27133961
107establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.27133961
108embryonic body morphogenesis (GO:0010172)3.26414211
109alkaloid metabolic process (GO:0009820)3.26253423
110positive regulation of receptor recycling (GO:0001921)3.26161294
111outflow tract septum morphogenesis (GO:0003148)3.25959452
112regulation of early endosome to late endosome transport (GO:2000641)3.24945142
113telomere maintenance via semi-conservative replication (GO:0032201)3.24390407
114DNA topological change (GO:0006265)3.24177108
115hypotonic response (GO:0006971)3.23857331
116protein localization to endosome (GO:0036010)3.22139933
117embryonic skeletal joint morphogenesis (GO:0060272)3.22113156
118respiratory system process (GO:0003016)3.22054155
119peptidyl-arginine N-methylation (GO:0035246)3.20698545
120peptidyl-arginine methylation (GO:0018216)3.20698545
121negative regulation of T cell differentiation in thymus (GO:0033085)3.20104409
122negative regulation of response to food (GO:0032096)3.19797349
123negative regulation of appetite (GO:0032099)3.19797349
124nucleotide-excision repair, DNA gap filling (GO:0006297)3.18677317
125meiotic chromosome segregation (GO:0045132)3.17851422
126synaptic vesicle endocytosis (GO:0048488)3.17049431
127positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.16009158
128regulation of response to reactive oxygen species (GO:1901031)3.13543939
129activation of Rac GTPase activity (GO:0032863)3.13250057
130positive regulation of circadian rhythm (GO:0042753)3.11178036
131pyrimidine nucleobase catabolic process (GO:0006208)3.09294737
132regulation of double-strand break repair via homologous recombination (GO:0010569)3.08950473
133middle ear morphogenesis (GO:0042474)3.08859573
134termination of RNA polymerase II transcription (GO:0006369)3.08498275
135deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.04423443
136response to misfolded protein (GO:0051788)3.03716339
137nucleosome disassembly (GO:0006337)3.02798039
138protein-DNA complex disassembly (GO:0032986)3.02798039
139mammary gland epithelial cell differentiation (GO:0060644)2.96335671
140ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.94346532
141regulation of cardioblast proliferation (GO:0003264)2.93621445
142regulation of secondary heart field cardioblast proliferation (GO:0003266)2.93621445
143rRNA transcription (GO:0009303)2.93441319
144embryonic skeletal system morphogenesis (GO:0048704)2.91632399
145positive regulation of synapse maturation (GO:0090129)2.87220607
146cochlea morphogenesis (GO:0090103)2.86062550
147sympathetic nervous system development (GO:0048485)2.83695509
148mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.83617635
149galactose catabolic process (GO:0019388)2.83397002
150dorsal/ventral neural tube patterning (GO:0021904)2.82580502
151pharyngeal system development (GO:0060037)2.82156475
152chromatin assembly (GO:0031497)2.78018078
153coronary vasculature morphogenesis (GO:0060977)2.76688816
154negative regulation of catenin import into nucleus (GO:0035414)2.76000804
155embryonic cranial skeleton morphogenesis (GO:0048701)2.73756612
156detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.73341810
157detection of temperature stimulus involved in sensory perception (GO:0050961)2.73341810
158regulation of protein heterodimerization activity (GO:0043497)2.69733995
159aorta morphogenesis (GO:0035909)2.69059761
160atrial septum morphogenesis (GO:0060413)2.67986213
161regulation of cardioblast differentiation (GO:0051890)2.65191496
162proximal/distal pattern formation (GO:0009954)2.64371165
163forelimb morphogenesis (GO:0035136)2.64317815
164folic acid metabolic process (GO:0046655)2.63054944
165viral transcription (GO:0019083)2.59581930
166positive regulation of muscle cell apoptotic process (GO:0010661)2.57582585
167cellular anion homeostasis (GO:0030002)2.55867590
168regulation of heart morphogenesis (GO:2000826)2.55382801
169pattern specification involved in kidney development (GO:0061004)2.54551914
170nucleobase catabolic process (GO:0046113)2.53456737
171regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.53195546
172embryonic viscerocranium morphogenesis (GO:0048703)2.52674124
173positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.52607863
174positive regulation of skeletal muscle tissue development (GO:0048643)2.52104368
175regulation of synapse structural plasticity (GO:0051823)2.51086215
176embryonic forelimb morphogenesis (GO:0035115)2.50713930
177regulation of mesonephros development (GO:0061217)2.49667286
178kidney mesenchyme development (GO:0072074)2.49475884
179metallo-sulfur cluster assembly (GO:0031163)2.47642801
180iron-sulfur cluster assembly (GO:0016226)2.47642801
181negative regulation of cell size (GO:0045792)2.46726145
182regulation of NFAT protein import into nucleus (GO:0051532)2.44082110
183* neuron fate specification (GO:0048665)2.43737460
184positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.42029735
185DNA replication checkpoint (GO:0000076)2.38797031
186amyloid precursor protein catabolic process (GO:0042987)2.38162506
187positive regulation of T cell apoptotic process (GO:0070234)2.37867611
188pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.33941563
189pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.33606454
190regulation of nuclear cell cycle DNA replication (GO:0033262)2.33460902
191translational termination (GO:0006415)2.33158113
192translational elongation (GO:0006414)2.33016210
193detection of temperature stimulus (GO:0016048)2.32949695
194heart morphogenesis (GO:0003007)2.31745699
195proline biosynthetic process (GO:0006561)11.1709783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.83300614
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.72809174
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.62791830
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.49402485
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.49402485
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.49402485
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.13331634
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.09126545
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.84778998
10SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.80302193
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.73680200
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.61038760
13EZH2_22144423_ChIP-Seq_EOC_Human2.51254196
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.48870641
15VDR_21846776_ChIP-Seq_THP-1_Human2.47134803
16POU5F1_16518401_ChIP-PET_MESCs_Mouse2.43661507
17KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.43026190
18LXR_22292898_ChIP-Seq_THP-1_Human2.35235344
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.32361904
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.32266400
21XRN2_22483619_ChIP-Seq_HELA_Human2.31143706
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30981935
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28556385
24* EZH2_27304074_Chip-Seq_ESCs_Mouse2.25407239
25* EED_16625203_ChIP-ChIP_MESCs_Mouse2.23324658
26TCF3_18692474_ChIP-Seq_MESCs_Mouse2.20499547
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.19836939
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.12612060
29* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.10260389
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.05376802
31* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00287523
32* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00287523
33* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99466887
34* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95415316
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94904488
36* CBX2_27304074_Chip-Seq_ESCs_Mouse1.93718354
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.89229833
38PU.1_20513432_ChIP-Seq_Bcells_Mouse1.87820796
39ZNF263_19887448_ChIP-Seq_K562_Human1.87031197
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.84888061
41NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.82767709
42E2F7_22180533_ChIP-Seq_HELA_Human1.82376550
43NANOG_21062744_ChIP-ChIP_HESCs_Human1.81844384
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.80266959
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.79260212
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78271671
47* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.77537188
48* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75491888
49* EZH2_27294783_Chip-Seq_ESCs_Mouse1.70675900
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70377199
51P68_20966046_ChIP-Seq_HELA_Human1.68675408
52* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.67765541
53RACK7_27058665_Chip-Seq_MCF-7_Human1.66447256
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66277276
55* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65121971
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63473191
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62598760
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59462994
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58809106
60* TET1_21451524_ChIP-Seq_MESCs_Mouse1.58765232
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.58650451
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56266165
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56237286
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54237882
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51579023
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50063937
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49649373
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48761304
69* RNF2_27304074_Chip-Seq_ESCs_Mouse1.46055331
70POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.45343498
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43642410
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43517459
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42587067
74NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.42162694
75* KDM2B_26808549_Chip-Seq_DND41_Human1.41390048
76* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41293916
77NANOG_18692474_ChIP-Seq_MESCs_Mouse1.41090092
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41064097
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.39942744
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39839400
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38725282
82PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.38636779
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37589854
84STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.35551058
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35307432
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34636475
87* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33648760
88KDM2B_26808549_Chip-Seq_K562_Human1.33388152
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33200423
90SOX2_18692474_ChIP-Seq_MESCs_Mouse1.32363593
91ETS1_21867929_ChIP-Seq_TH2_Mouse1.31693323
92CTCF_18555785_ChIP-Seq_MESCs_Mouse1.30943876
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30562157
94RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30177789
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29612088
96TTF2_22483619_ChIP-Seq_HELA_Human1.27247223
97* CREB1_26743006_Chip-Seq_LNCaP_Human1.27056770
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26574065
99SMC4_20622854_ChIP-Seq_HELA_Human1.26539277
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.25987960
101MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25878396
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25811658
103MYC_22102868_ChIP-Seq_BL_Human1.25667058
104* RNF2_27304074_Chip-Seq_NSC_Mouse1.25601964
105RARB_24833708_ChIP-Seq_LIVER_Mouse1.25586895
106SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24734111
107* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24667156
108* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23621444
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22903707
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22883693
111TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.22876688
112SPI1_26923725_Chip-Seq_HPCs_Mouse1.22580740
113CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22054504
114CTCF_21964334_ChIP-Seq_BJAB-B_Human1.21162104
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20660018
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20332968
117* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19728612
118ETS1_20019798_ChIP-Seq_JURKAT_Human1.19473951
119FOXP1_21924763_ChIP-Seq_HESCs_Human1.19165878
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17324112
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16021261
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16010034
123ELK3_25401928_ChIP-Seq_HUVEC_Human1.15723975
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15527967
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14747082
126* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14609786
127* TP53_20018659_ChIP-ChIP_R1E_Mouse1.14498782
128NANOG_16518401_ChIP-PET_MESCs_Mouse1.13653032
129* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13510352
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13158892
131CTCF_27219007_Chip-Seq_Bcells_Human1.12502217
132OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12094785
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11878712
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10701912
135SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10698493
136SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10393957
137RARA_24833708_ChIP-Seq_LIVER_Mouse1.10092840
138* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09269264
139RARB_27405468_Chip-Seq_BRAIN_Mouse1.08417810
140BCOR_27268052_Chip-Seq_Bcells_Human1.07978282
141* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07381986
142CDX2_20551321_ChIP-Seq_CACO-2_Human1.06734190
143RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06682887
144SA1_27219007_Chip-Seq_ERYTHROID_Human1.06131812
145TET1_21490601_ChIP-Seq_MESCs_Mouse1.05736149
146YY1_21170310_ChIP-Seq_MESCs_Mouse1.05544690
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04149643
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02950184
149E2F1_20622854_ChIP-Seq_HELA_Human1.02392128
150NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02227549
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01649630
152* RING1B_27294783_Chip-Seq_NPCs_Mouse1.01407013
153YY1_22570637_ChIP-Seq_MALME-3M_Human1.00840593
154STAT1_20625510_ChIP-Seq_HELA_Human0.99790743
155POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98573977
156KDM2B_26808549_Chip-Seq_JURKAT_Human0.95950436
157* PHF8_20622854_ChIP-Seq_HELA_Human0.95758229
158E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95746549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.93734426
2MP0005171_absent_coat_pigmentation5.30457978
3MP0009278_abnormal_bone_marrow4.68742687
4MP0010030_abnormal_orbit_morphology4.05229909
5MP0004233_abnormal_muscle_weight3.88904239
6MP0002009_preneoplasia3.57919194
7MP0005623_abnormal_meninges_morphology3.29802031
8MP0002234_abnormal_pharynx_morphology3.27080099
9MP0001188_hyperpigmentation3.17461027
10MP0000049_abnormal_middle_ear3.16439196
11MP0002822_catalepsy3.09582288
12MP0003283_abnormal_digestive_organ2.84221451
13MP0005423_abnormal_somatic_nervous2.75350544
14MP0008995_early_reproductive_senescence2.71978603
15MP0000678_abnormal_parathyroid_gland2.60681192
16MP0001346_abnormal_lacrimal_gland2.52024277
17MP0003890_abnormal_embryonic-extraembry2.42493491
18MP0004859_abnormal_synaptic_plasticity2.41299420
19MP0006072_abnormal_retinal_apoptosis2.26076048
20MP0002653_abnormal_ependyma_morphology2.23390759
21MP0005174_abnormal_tail_pigmentation2.17482741
22MP0004858_abnormal_nervous_system2.14001084
23MP0001545_abnormal_hematopoietic_system2.13588518
24MP0005397_hematopoietic_system_phenotyp2.13588518
25MP0002249_abnormal_larynx_morphology2.12988972
26MP0004133_heterotaxia2.11817593
27MP0003119_abnormal_digestive_system2.01285852
28MP0002163_abnormal_gland_morphology1.97220717
29MP0002160_abnormal_reproductive_system1.95833121
30MP0002282_abnormal_trachea_morphology1.94767643
31MP0000579_abnormal_nail_morphology1.93945967
32MP0003453_abnormal_keratinocyte_physiol1.85124785
33MP0002877_abnormal_melanocyte_morpholog1.83846849
34MP0001502_abnormal_circadian_rhythm1.81348439
35MP0000537_abnormal_urethra_morphology1.80712611
36MP0010094_abnormal_chromosome_stability1.79382576
37MP0004185_abnormal_adipocyte_glucose1.76679512
38MP0001348_abnormal_lacrimal_gland1.75467461
39MP0003786_premature_aging1.72099169
40MP0001293_anophthalmia1.69111035
41MP0009250_abnormal_appendicular_skeleto1.68706827
42MP0000003_abnormal_adipose_tissue1.68620121
43MP0005409_darkened_coat_color1.67817347
44MP0003172_abnormal_lysosome_physiology1.62478291
45MP0003938_abnormal_ear_development1.61000309
46MP0005076_abnormal_cell_differentiation1.58277347
47MP0000015_abnormal_ear_pigmentation1.57939290
48MP0003635_abnormal_synaptic_transmissio1.54728745
49MP0003942_abnormal_urinary_system1.53963312
50MP0002084_abnormal_developmental_patter1.53232648
51MP0003879_abnormal_hair_cell1.50229936
52MP0002086_abnormal_extraembryonic_tissu1.48190232
53MP0000534_abnormal_ureter_morphology1.45956379
54MP0008877_abnormal_DNA_methylation1.45555164
55MP0003937_abnormal_limbs/digits/tail_de1.45045416
56MP0002269_muscular_atrophy1.44767920
57MP0000462_abnormal_digestive_system1.44642840
58MP0006276_abnormal_autonomic_nervous1.44187771
59MP0008932_abnormal_embryonic_tissue1.43872369
60MP0000470_abnormal_stomach_morphology1.42477397
61MP0002697_abnormal_eye_size1.42318094
62MP0001697_abnormal_embryo_size1.39337518
63MP0001340_abnormal_eyelid_morphology1.39335282
64MP0002733_abnormal_thermal_nociception1.38984086
65MP0000639_abnormal_adrenal_gland1.38512598
66MP0000733_abnormal_muscle_development1.37608838
67MP0000371_diluted_coat_color1.34523692
68MP0004957_abnormal_blastocyst_morpholog1.33240263
69MP0002085_abnormal_embryonic_tissue1.32700677
70MP0010352_gastrointestinal_tract_polyps1.31403410
71MP0003045_fibrosis1.31119617
72MP0005058_abnormal_lysosome_morphology1.30864487
73MP0005187_abnormal_penis_morphology1.30339709
74MP0004197_abnormal_fetal_growth/weight/1.29306896
75MP0003693_abnormal_embryo_hatching1.28804807
76MP0005075_abnormal_melanosome_morpholog1.28109652
77MP0002184_abnormal_innervation1.26262932
78MP0000631_abnormal_neuroendocrine_gland1.25002183
79MP0002557_abnormal_social/conspecific_i1.23894578
80MP0003315_abnormal_perineum_morphology1.23130662
81MP0002796_impaired_skin_barrier1.20415986
82MP0002063_abnormal_learning/memory/cond1.18067161
83MP0003861_abnormal_nervous_system1.17984671
84MP0002734_abnormal_mechanical_nocicepti1.16647502
85MP0002092_abnormal_eye_morphology1.14894725
86MP0003567_abnormal_fetal_cardiomyocyte1.13826072
87MP0001970_abnormal_pain_threshold1.13378874
88MP0005645_abnormal_hypothalamus_physiol1.12965436
89MP0004270_analgesia1.12365583
90MP0001905_abnormal_dopamine_level1.11696015
91MP0003122_maternal_imprinting1.11246627
92MP0002064_seizures1.10954687
93MP0002177_abnormal_outer_ear1.10590299
94MP0000762_abnormal_tongue_morphology1.10296069
95MP0003137_abnormal_impulse_conducting1.09500235
96* MP0002882_abnormal_neuron_morphology1.09234782
97MP0008260_abnormal_autophagy1.08650462
98MP0009745_abnormal_behavioral_response1.08365839
99MP0008058_abnormal_DNA_repair1.07823354
100MP0002111_abnormal_tail_morphology1.06434336
101MP0009379_abnormal_foot_pigmentation1.04955597
102MP0004142_abnormal_muscle_tone1.04319016
103MP0000490_abnormal_crypts_of1.03400440
104MP0003123_paternal_imprinting1.03131582
105MP0002152_abnormal_brain_morphology1.01922848
106MP0002932_abnormal_joint_morphology1.01824906
107MP0003828_pulmonary_edema1.00648363
108MP0003656_abnormal_erythrocyte_physiolo0.99937752
109MP0002752_abnormal_somatic_nervous0.99777455
110MP0002751_abnormal_autonomic_nervous0.98660953
111MP0008004_abnormal_stomach_pH0.97591304
112MP0003077_abnormal_cell_cycle0.96838425
113MP0001672_abnormal_embryogenesis/_devel0.95754003
114MP0005380_embryogenesis_phenotype0.95754003
115MP0003755_abnormal_palate_morphology0.94667694
116MP0002735_abnormal_chemical_nociception0.94613080
117MP0005085_abnormal_gallbladder_physiolo0.94397274
118MP0002572_abnormal_emotion/affect_behav0.94372108
119MP0002114_abnormal_axial_skeleton0.94336967
120MP0005389_reproductive_system_phenotype0.92020566
121* MP0002081_perinatal_lethality0.90874418
122MP0000566_synostosis0.86585331
123MP0009115_abnormal_fat_cell0.85624860
124MP0003935_abnormal_craniofacial_develop0.85559418
125MP0003880_abnormal_central_pattern0.85372314
126MP0005375_adipose_tissue_phenotype0.85106653
127MP0001919_abnormal_reproductive_system0.84027435
128MP0003111_abnormal_nucleus_morphology0.84013687
129MP0002075_abnormal_coat/hair_pigmentati0.83951270
130MP0003121_genomic_imprinting0.83052122
131MP0001324_abnormal_eye_pigmentation0.82108908
132MP0002116_abnormal_craniofacial_bone0.82057010
133MP0001286_abnormal_eye_development0.81752504
134MP0005499_abnormal_olfactory_system0.80736477
135MP0005394_taste/olfaction_phenotype0.80736477
136MP0000350_abnormal_cell_proliferation0.79580795
137MP0005646_abnormal_pituitary_gland0.77100115
138MP0002272_abnormal_nervous_system0.76864334
139MP0002080_prenatal_lethality0.76523467
140MP0005266_abnormal_metabolism0.75640291
141MP0002098_abnormal_vibrissa_morphology0.74993005
142MP0000013_abnormal_adipose_tissue0.74941525
143MP0004742_abnormal_vestibular_system0.74304828
144MP0001730_embryonic_growth_arrest0.72718072
145MP0003385_abnormal_body_wall0.71871537
146MP0009046_muscle_twitch0.71850118
147MP0000751_myopathy0.71811756
148MP0000467_abnormal_esophagus_morphology0.71720002
149MP0005253_abnormal_eye_physiology0.71000269
150MP0003136_yellow_coat_color0.70914358
151MP0005501_abnormal_skin_physiology0.70559646
152* MP0000955_abnormal_spinal_cord0.70017369
153MP0001186_pigmentation_phenotype0.69218238
154MP0004264_abnormal_extraembryonic_tissu0.68406031
155MP0002019_abnormal_tumor_incidence0.67888560
156MP0002060_abnormal_skin_morphology0.67748360
157MP0000432_abnormal_head_morphology0.66827271
158MP0000516_abnormal_urinary_system0.66809186
159MP0005367_renal/urinary_system_phenotyp0.66809186
160MP0005330_cardiomyopathy0.66492487
161MP0002332_abnormal_exercise_endurance0.66424770
162MP0005508_abnormal_skeleton_morphology0.64775057
163MP0005365_abnormal_bile_salt0.64256251
164MP0009053_abnormal_anal_canal0.63040823
165MP0003984_embryonic_growth_retardation0.62653245
166MP0000778_abnormal_nervous_system0.61830335
167MP0010630_abnormal_cardiac_muscle0.61494029
168MP0002108_abnormal_muscle_morphology0.61209992
169MP0000681_abnormal_thyroid_gland0.60845275
170MP0004811_abnormal_neuron_physiology0.59820823

Predicted human phenotypes

RankGene SetZ-score
1Congenital malformation of the right heart (HP:0011723)5.68746394
2Double outlet right ventricle (HP:0001719)5.68746394
3Concave nail (HP:0001598)5.53780809
4Annular pancreas (HP:0001734)5.53640172
5Rib fusion (HP:0000902)5.48725793
6Facial hemangioma (HP:0000329)5.03115117
7Turricephaly (HP:0000262)4.83322537
8Increased IgM level (HP:0003496)4.82835913
9Rectal fistula (HP:0100590)4.80454912
10Rectovaginal fistula (HP:0000143)4.80454912
11Pustule (HP:0200039)4.73828201
12Alopecia of scalp (HP:0002293)4.52844914
13Hyperthyroidism (HP:0000836)4.51276622
14Hypochromic microcytic anemia (HP:0004840)4.48619567
15Intestinal fistula (HP:0100819)4.32930888
16Vaginal fistula (HP:0004320)4.22693583
17Truncus arteriosus (HP:0001660)4.21859816
18Abnormal hemoglobin (HP:0011902)4.21190122
19Poikiloderma (HP:0001029)4.09111052
20Ulnar bowing (HP:0003031)4.07679572
21Coronal craniosynostosis (HP:0004440)4.05121437
22Down-sloping shoulders (HP:0200021)3.95886345
23Tongue fasciculations (HP:0001308)3.93449320
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.92279954
25Breast hypoplasia (HP:0003187)3.81466167
26Orthostatic hypotension (HP:0001278)3.80369374
27Birth length less than 3rd percentile (HP:0003561)3.79928722
28Muscle fibrillation (HP:0010546)3.72508830
29Short humerus (HP:0005792)3.68031093
30Preauricular pit (HP:0004467)3.65782148
31Periauricular skin pits (HP:0100277)3.65782148
32Dysautonomia (HP:0002459)3.65085283
33Male infertility (HP:0003251)3.63457655
34Intestinal atresia (HP:0011100)3.55081725
35High anterior hairline (HP:0009890)3.52119261
36Aplasia/hypoplasia of the humerus (HP:0006507)3.48873083
37Shawl scrotum (HP:0000049)3.47352150
38Anteriorly placed anus (HP:0001545)3.46667033
39Alacrima (HP:0000522)3.41629686
40Congenital hip dislocation (HP:0001374)3.40135643
41Vertebral hypoplasia (HP:0008417)3.39756827
42Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.39756827
43Transposition of the great arteries (HP:0001669)3.36065968
44Abnormal connection of the cardiac segments (HP:0011545)3.36065968
45Abnormal ventriculo-arterial connection (HP:0011563)3.36065968
46Abnormality of the aortic arch (HP:0012303)3.29486814
47Unilateral renal agenesis (HP:0000122)3.28691506
48Myokymia (HP:0002411)3.25661217
49Abnormality of male internal genitalia (HP:0000022)3.22101686
50Short chin (HP:0000331)3.15690239
51Choanal stenosis (HP:0000452)3.04484350
52Broad alveolar ridges (HP:0000187)3.02866838
53Absent radius (HP:0003974)3.02072841
54Urinary glycosaminoglycan excretion (HP:0003541)3.02071594
55Mucopolysacchariduria (HP:0008155)3.02071594
56Hypotrichosis (HP:0001006)3.00595074
57Hypoparathyroidism (HP:0000829)2.99691690
58Symphalangism affecting the phalanges of the hand (HP:0009773)2.98375258
59Premature skin wrinkling (HP:0100678)2.92738093
60Popliteal pterygium (HP:0009756)2.92532773
61Diaphragmatic weakness (HP:0009113)2.91976186
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90971268
63Amblyopia (HP:0000646)2.89956137
64Large for gestational age (HP:0001520)2.87032155
65Absent forearm bone (HP:0003953)2.85185131
66Aplasia involving forearm bones (HP:0009822)2.85185131
67Growth hormone excess (HP:0000845)2.80443017
68Hamartoma (HP:0010566)2.79614005
69Atelectasis (HP:0100750)2.79128569
70Pancreatic islet-cell hyperplasia (HP:0004510)2.76583491
71Bifid uvula (HP:0000193)2.73857580
72Aplasia/Hypoplasia of the clavicles (HP:0006710)2.72630539
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.71646914
74Abnormality of polysaccharide metabolism (HP:0011012)2.71646914
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.71646914
76Hypoplastic left heart (HP:0004383)2.69795026
77Dysostosis multiplex (HP:0000943)2.68885031
78Hypercortisolism (HP:0001578)2.68455552
79Albinism (HP:0001022)2.67858635
80Sparse lateral eyebrow (HP:0005338)2.65395456
81Absent thumb (HP:0009777)2.62352970
82Squamous cell carcinoma (HP:0002860)2.61889524
83Clumsiness (HP:0002312)2.57224829
84Aplasia of the musculature (HP:0100854)2.57120925
85Hypokinesia (HP:0002375)2.55855847
86Broad distal phalanx of finger (HP:0009836)2.52427231
87Decreased lacrimation (HP:0000633)2.51937374
88Basal cell carcinoma (HP:0002671)2.51561903
89Narrow nasal bridge (HP:0000446)2.51253486
90Volvulus (HP:0002580)2.42685351
91Patellar aplasia (HP:0006443)2.42506784
92Hypotelorism (HP:0000601)2.42238303
93Joint stiffness (HP:0001387)2.41561050
94Capillary hemangiomas (HP:0005306)2.41110927
95Split hand (HP:0001171)2.41055426
96Cerebral aneurysm (HP:0004944)2.32638884
97Hypoplastic heart (HP:0001961)2.31948947
98Renal agenesis (HP:0000104)2.30915664
99Exotropia (HP:0000577)2.30705872
100Hypochromic anemia (HP:0001931)2.30645783
101Bowed forearm bones (HP:0003956)2.26295300
102Bowing of the arm (HP:0006488)2.26295300
103Abnormality of chromosome segregation (HP:0002916)2.26150103
104Increased number of teeth (HP:0011069)2.25988057
105Oligodactyly (hands) (HP:0001180)2.23968045
106Abnormality of the labia minora (HP:0012880)2.23782662
107Skin pits (HP:0100276)2.21609461
108Aplasia/Hypoplasia of the patella (HP:0006498)2.21337031
109Peritonitis (HP:0002586)2.20348328
110Polycythemia (HP:0001901)2.20201999
111Gastrointestinal atresia (HP:0002589)2.18495777
112Achilles tendon contracture (HP:0001771)2.18400795
113Optic nerve coloboma (HP:0000588)2.17316611
114Diminished movement (HP:0002374)2.17274198
115Vertebral fusion (HP:0002948)2.16848518
116Visual hallucinations (HP:0002367)2.16294977
117Reticulocytopenia (HP:0001896)2.15872361
118Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.14487390
119Bulbar palsy (HP:0001283)2.13966158
120Premature graying of hair (HP:0002216)2.13724443
121Amelogenesis imperfecta (HP:0000705)2.13322345
122Redundant skin (HP:0001582)2.10293173
123Tetany (HP:0001281)2.09241389
124Asymmetric septal hypertrophy (HP:0001670)2.08531041
125Abnormality of the parathyroid morphology (HP:0011766)2.08056022
126Lower limb hyperreflexia (HP:0002395)2.07981104
127IgA deficiency (HP:0002720)2.07395668
128Selective tooth agenesis (HP:0001592)2.06633557
129Acute lymphatic leukemia (HP:0006721)2.04565095
130Morphological abnormality of the middle ear (HP:0008609)2.02820755
131Hypertensive crisis (HP:0100735)2.02039576
132Abnormality of the lower motor neuron (HP:0002366)2.00377706
133Overfolded helix (HP:0000396)2.00072989
134Lymphangioma (HP:0100764)1.98612749
135Abnormally folded helix (HP:0008544)1.97779602
136Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97506346
137Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97506346
138Rectal prolapse (HP:0002035)1.96803812
139Depression (HP:0000716)1.96168431
140Cutaneous finger syndactyly (HP:0010554)1.95381990
141Oligodactyly (HP:0012165)1.93498519
142Abnormality of the phalanges of the 5th finger (HP:0004213)1.92174556
143Abnormality of the Achilles tendon (HP:0005109)1.91438445
144Progressive cerebellar ataxia (HP:0002073)1.91056028
145Abnormal number of incisors (HP:0011064)1.90291458
146Increased CSF protein (HP:0002922)1.90162115
147Abnormality of the astrocytes (HP:0100707)1.89994565
148Astrocytoma (HP:0009592)1.89994565
149Atonic seizures (HP:0010819)1.89074433
150Anophthalmia (HP:0000528)1.86850954
151Hypoplasia of the ulna (HP:0003022)1.86534871
152Abnormal autonomic nervous system physiology (HP:0012332)1.84431189
153Ragged-red muscle fibers (HP:0003200)1.83329379
154Hypoplasia of the radius (HP:0002984)1.82310216
155Generalized amyotrophy (HP:0003700)1.81828084
156Abnormality of the intervertebral disk (HP:0005108)1.81732004
157Abnormal umbilical cord blood vessels (HP:0011403)1.80300560
158Single umbilical artery (HP:0001195)1.80300560
159Abnormality of the fetal cardiovascular system (HP:0010948)1.80300560
160Aplasia/Hypoplasia of the nipples (HP:0006709)1.80273732
161Patellar dislocation (HP:0002999)1.78773588
162Impulsivity (HP:0100710)1.78420500
163Agitation (HP:0000713)1.77306063
164Broad hallux (HP:0010055)1.76737466
165Elevated erythrocyte sedimentation rate (HP:0003565)1.73964678
166Abnormality of the phalanges of the hallux (HP:0010057)1.73923224
167Hyperacusis (HP:0010780)1.72521483
168Cutaneous syndactyly (HP:0012725)1.71588911
169Supernumerary nipples (HP:0002558)1.70539062
170Abnormality of cochlea (HP:0000375)1.70320543
171Split foot (HP:0001839)1.68210692
172Short clavicles (HP:0000894)1.67630071
173Synostosis involving bones of the hand (HP:0004278)1.67040926
174Anomalous pulmonary venous return (HP:0010772)1.66620752
175Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65362458
176Prolonged neonatal jaundice (HP:0006579)1.63579329
177Fibular aplasia (HP:0002990)1.63157372
178Abnormality of the distal phalanges of the toes (HP:0010182)1.61897714
179Adducted thumb (HP:0001181)1.61859996
180Aplasia/Hypoplasia of the macula (HP:0008059)1.60958816
181Abnormality of the middle phalanges of the toes (HP:0010183)1.60406262
182Abnormal finger flexion creases (HP:0006143)1.60060212
183Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.59325185
184Sclerocornea (HP:0000647)1.58390902
185Aplasia/Hypoplasia of the lens (HP:0008063)1.57540755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.17783463
2DDR25.15949116
3MAPK155.10879423
4MAP3K64.72732985
5SMG13.87295850
6EPHB23.61914460
7PINK13.49083756
8MAP3K113.48608440
9MATK3.38406828
10TYRO33.06034370
11FGR3.05054137
12VRK22.82833726
13UHMK12.64093633
14DAPK12.54933949
15NME22.51987092
16BUB12.51290535
17PRKD32.48096440
18BMX2.30478996
19EEF2K2.26283106
20PRKD22.24812950
21PIM22.10255106
22YES12.10241977
23PDGFRA2.10235261
24CSK2.08501427
25MAP2K72.05828772
26TAF12.05076598
27PDK21.97214511
28DYRK1B1.88944196
29CSNK1G31.71453869
30LATS21.67740680
31MARK11.65225670
32IRAK31.62863568
33CSNK1G21.61470442
34CSNK1A1L1.59605868
35AKT31.58963574
36PKN11.55541574
37PHKG11.53060528
38PHKG21.53060528
39CDK71.49091378
40TRPM71.46870703
41BRSK11.39058744
42STK161.38462808
43ILK1.35839052
44CDC42BPA1.33414419
45BRAF1.30274515
46CDK61.24189260
47RPS6KL11.23996770
48RPS6KC11.23996770
49ARAF1.20332719
50MAP3K41.19973224
51CDC71.15650413
52PIM11.15469852
53STK111.10562421
54GSK3A1.09091827
55RPS6KA21.07585215
56MAPK111.07415161
57RPS6KA61.05546962
58ABL21.04689588
59PRPF4B1.01066375
60CAMK1D0.98082198
61MAPKAPK50.93201387
62CAMKK10.92687661
63IRAK20.92300202
64CHEK20.90763358
65HIPK20.84967812
66MAP3K90.84183228
67CAMK1G0.80801023
68AKT20.79156839
69CDK90.75891206
70GRK50.74580781
71VRK10.72643412
72PRKAA10.71252472
73DMPK0.70663752
74NME10.69708446
75RPS6KA50.69284972
76KDR0.68991279
77DAPK30.68761258
78CASK0.66296622
79ADRBK20.66007667
80CAMKK20.64247802
81RPS6KA10.63998247
82PLK10.61841317
83MAP3K100.61311620
84MTOR0.60945308
85PRKCI0.57847166
86BMPR1B0.56431472
87TAOK20.55794223
88PDPK10.54857727
89DYRK30.54402069
90MST1R0.53712849
91CHEK10.52226334
92DYRK1A0.48892472
93RAF10.48040287
94CAMK2B0.47575200
95CAMK2G0.47204454
96STK40.47189865
97MAP2K20.46946439
98CSNK1E0.46727396
99MAP2K40.44656698
100ERBB30.43271875
101AURKB0.42372760
102EGFR0.42225007
103CDK50.41785028
104RPS6KB10.41254559
105LRRK20.41241190
106DYRK20.39116721
107BCKDK0.38455292
108RPS6KB20.38411159
109NTRK10.37954505
110PDGFRB0.37837194
111TRIB30.37328934
112CDK20.37245344
113CSNK1G10.36614237
114TNK20.36423641
115MAPK100.35454715
116CSNK2A10.34472046
117MAPK30.33664372
118MAPK10.32140341
119MAPK40.32016183
120CAMK2A0.31499926
121LYN0.30711249
122PTK20.30485633
123CAMK2D0.29818918
124TLK10.29607699
125AURKA0.29052842
126ATR0.28282739
127PAK60.27646186
128PRKAA20.26623773
129RIPK10.26292271
130TAOK10.26286307
131PRKCZ0.26036480
132STK380.25738848
133MAPK140.25681606
134INSR0.24479762
135ALK0.23783064
136KSR20.23516628
137MAPKAPK30.22856627
138SGK10.22477473
139CDK11A0.22275304
140CDK150.22177265
141CSNK2A20.21786685
142PRKD10.21159650
143MAPKAPK20.20673517
144CDK180.19141601
145RPS6KA30.18390343
146CDK80.18058907
147CDK140.17945424
148TESK20.17769249
149CDK120.17715224
150CDK10.17401676
151ATM0.17124576
152MARK20.16704323
153GSK3B0.15718902
154SIK20.15511368
155EPHA20.15065815
156NTRK20.13940089
157PRKCD0.13664895

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.27186763
2Mismatch repair_Homo sapiens_hsa034304.39959199
3Base excision repair_Homo sapiens_hsa034104.37235967
4Ribosome_Homo sapiens_hsa030103.05087061
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.87748469
6DNA replication_Homo sapiens_hsa030302.83505215
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.78860973
8Vitamin B6 metabolism_Homo sapiens_hsa007502.69380839
9Hedgehog signaling pathway_Homo sapiens_hsa043402.41477314
10mTOR signaling pathway_Homo sapiens_hsa041502.40257953
11Circadian rhythm_Homo sapiens_hsa047102.31709815
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.26487267
13Hippo signaling pathway_Homo sapiens_hsa043902.14516896
14Arginine and proline metabolism_Homo sapiens_hsa003302.01629090
15Notch signaling pathway_Homo sapiens_hsa043301.98768911
16Adherens junction_Homo sapiens_hsa045201.77883451
17Synaptic vesicle cycle_Homo sapiens_hsa047211.77257311
18mRNA surveillance pathway_Homo sapiens_hsa030151.71825611
19Nucleotide excision repair_Homo sapiens_hsa034201.67996792
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59060647
21Bladder cancer_Homo sapiens_hsa052191.51380898
22Sulfur relay system_Homo sapiens_hsa041221.49949952
23Longevity regulating pathway - mammal_Homo sapiens_hsa042111.48491860
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47253670
25Fatty acid metabolism_Homo sapiens_hsa012121.47051868
26TGF-beta signaling pathway_Homo sapiens_hsa043501.45922997
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43877498
28Biosynthesis of amino acids_Homo sapiens_hsa012301.41788552
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39387311
30Wnt signaling pathway_Homo sapiens_hsa043101.38258831
31Axon guidance_Homo sapiens_hsa043601.35729544
32p53 signaling pathway_Homo sapiens_hsa041151.35086968
33VEGF signaling pathway_Homo sapiens_hsa043701.35066826
34Nicotine addiction_Homo sapiens_hsa050331.34235754
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.33781710
36RNA transport_Homo sapiens_hsa030131.33047569
37Spliceosome_Homo sapiens_hsa030401.32683380
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29964521
39Basal cell carcinoma_Homo sapiens_hsa052171.29475658
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29423397
41Dorso-ventral axis formation_Homo sapiens_hsa043201.26961213
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26933528
43Fructose and mannose metabolism_Homo sapiens_hsa000511.24787426
44Oxidative phosphorylation_Homo sapiens_hsa001901.23971588
45Vibrio cholerae infection_Homo sapiens_hsa051101.22455546
46Fanconi anemia pathway_Homo sapiens_hsa034601.21958442
47Cocaine addiction_Homo sapiens_hsa050301.21683599
48Shigellosis_Homo sapiens_hsa051311.20545447
49Oocyte meiosis_Homo sapiens_hsa041141.19970441
50Sulfur metabolism_Homo sapiens_hsa009201.15599803
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14977099
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13209888
53Homologous recombination_Homo sapiens_hsa034401.12243083
54Pyrimidine metabolism_Homo sapiens_hsa002401.12004852
55Phenylalanine metabolism_Homo sapiens_hsa003601.04679153
56Colorectal cancer_Homo sapiens_hsa052101.02460168
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02456967
58Non-small cell lung cancer_Homo sapiens_hsa052231.02281569
59Lysine degradation_Homo sapiens_hsa003101.00310951
60Gap junction_Homo sapiens_hsa045401.00119186
61Alcoholism_Homo sapiens_hsa050340.99186434
62Collecting duct acid secretion_Homo sapiens_hsa049660.97318473
63Parkinsons disease_Homo sapiens_hsa050120.96744340
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96677779
65Arginine biosynthesis_Homo sapiens_hsa002200.95238067
66ErbB signaling pathway_Homo sapiens_hsa040120.93809779
67Alzheimers disease_Homo sapiens_hsa050100.93409482
68Folate biosynthesis_Homo sapiens_hsa007900.92753076
69Basal transcription factors_Homo sapiens_hsa030220.92448470
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89801578
71RNA polymerase_Homo sapiens_hsa030200.89716468
72Huntingtons disease_Homo sapiens_hsa050160.89554461
73Thyroid cancer_Homo sapiens_hsa052160.88635769
74Choline metabolism in cancer_Homo sapiens_hsa052310.84966282
75* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84223390
76Insulin signaling pathway_Homo sapiens_hsa049100.84132753
77Glioma_Homo sapiens_hsa052140.84023109
78Cell cycle_Homo sapiens_hsa041100.83945981
79Tight junction_Homo sapiens_hsa045300.82573174
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81448836
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.80556095
82Pancreatic cancer_Homo sapiens_hsa052120.79882591
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78897288
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77872157
85Dopaminergic synapse_Homo sapiens_hsa047280.76055397
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.73920476
87Morphine addiction_Homo sapiens_hsa050320.71844084
88Cholinergic synapse_Homo sapiens_hsa047250.71416546
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.70710321
90Galactose metabolism_Homo sapiens_hsa000520.70353848
91Purine metabolism_Homo sapiens_hsa002300.65744515
92Chronic myeloid leukemia_Homo sapiens_hsa052200.63957708
93AMPK signaling pathway_Homo sapiens_hsa041520.63013049
94Steroid biosynthesis_Homo sapiens_hsa001000.62837802
95Glutamatergic synapse_Homo sapiens_hsa047240.62795692
96Circadian entrainment_Homo sapiens_hsa047130.62771490
97MicroRNAs in cancer_Homo sapiens_hsa052060.62710063
98Endometrial cancer_Homo sapiens_hsa052130.60252300
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59951314
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58249647
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57846099
102Viral myocarditis_Homo sapiens_hsa054160.57530724
103Acute myeloid leukemia_Homo sapiens_hsa052210.56719618
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55793814
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.55494898
106Cardiac muscle contraction_Homo sapiens_hsa042600.54011054
107MAPK signaling pathway_Homo sapiens_hsa040100.52300501
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51944988
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49687338
110Prion diseases_Homo sapiens_hsa050200.46486111
111Primary immunodeficiency_Homo sapiens_hsa053400.45330402
112Type II diabetes mellitus_Homo sapiens_hsa049300.45226878
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44472214
114Mineral absorption_Homo sapiens_hsa049780.42276078
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41762679
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40307817
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39099012
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38997196
119GnRH signaling pathway_Homo sapiens_hsa049120.38793132
120Endocytosis_Homo sapiens_hsa041440.38672251
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37896322
122Estrogen signaling pathway_Homo sapiens_hsa049150.37684523
123Carbon metabolism_Homo sapiens_hsa012000.36152675
124Proteoglycans in cancer_Homo sapiens_hsa052050.34613147
125GABAergic synapse_Homo sapiens_hsa047270.33897814
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32279371
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31691873
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30407889
129Long-term depression_Homo sapiens_hsa047300.30253509
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27807682
131Viral carcinogenesis_Homo sapiens_hsa052030.26535460
132Small cell lung cancer_Homo sapiens_hsa052220.26007382
133Fatty acid elongation_Homo sapiens_hsa000620.24190232
134Legionellosis_Homo sapiens_hsa051340.23600578
135Melanoma_Homo sapiens_hsa052180.22348184
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.21963089
137Focal adhesion_Homo sapiens_hsa045100.21027668
138Rap1 signaling pathway_Homo sapiens_hsa040150.20326255
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20053346
140Prostate cancer_Homo sapiens_hsa052150.19086410
141Pathways in cancer_Homo sapiens_hsa052000.19039562
142HIF-1 signaling pathway_Homo sapiens_hsa040660.18776151
143Glutathione metabolism_Homo sapiens_hsa004800.18657461
144Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18511641
145Melanogenesis_Homo sapiens_hsa049160.17598452
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.17334918
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15274381
148Starch and sucrose metabolism_Homo sapiens_hsa005000.14783052

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