TLR7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.13059569
2* modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.13059569
3* positive regulation by organism of defense response of other organism involved in symbiotic interact7.13059569
4* modulation by symbiont of host immune response (GO:0052553)7.13059569
5* positive regulation by symbiont of host defense response (GO:0052509)7.13059569
6* modulation by symbiont of host defense response (GO:0052031)7.13059569
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.49129070
8* regulation of interferon-beta biosynthetic process (GO:0045357)6.20387281
9* macrophage activation involved in immune response (GO:0002281)5.59400219
10* microglial cell activation (GO:0001774)5.28136589
11* positive regulation of interferon-alpha production (GO:0032727)5.12386412
12neutrophil activation involved in immune response (GO:0002283)5.04413225
13immunoglobulin mediated immune response (GO:0016064)4.86930214
14* regulation of interferon-alpha production (GO:0032647)4.84418014
15regulation of B cell receptor signaling pathway (GO:0050855)4.84081568
16response to peptidoglycan (GO:0032494)4.57813081
17* response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.44526925
18* response to host immune response (GO:0052572)4.44526925
19detection of other organism (GO:0098543)4.27869531
20B cell proliferation (GO:0042100)4.24722297
21NIK/NF-kappaB signaling (GO:0038061)4.21178782
22detection of bacterium (GO:0016045)4.17744663
23regulation of gamma-delta T cell activation (GO:0046643)4.16224333
24T cell migration (GO:0072678)4.15078668
25respiratory burst (GO:0045730)4.14452913
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.13277244
27* macrophage activation (GO:0042116)4.09835515
28positive regulation of antigen processing and presentation (GO:0002579)4.08028844
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.06276199
30* response to host (GO:0075136)4.05479306
31* response to host defenses (GO:0052200)4.05479306
32* response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.05479306
33positive regulation of gamma-delta T cell activation (GO:0046645)3.99125222
34negative thymic T cell selection (GO:0045060)3.90895124
35* myeloid cell activation involved in immune response (GO:0002275)3.88276694
36* positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.87708761
37CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.87463221
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.81190982
39negative regulation of cell killing (GO:0031342)3.79670341
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.79670341
41positive thymic T cell selection (GO:0045059)3.77676973
42granulocyte activation (GO:0036230)3.75389857
43T-helper 1 type immune response (GO:0042088)3.71779734
44* positive regulation of interferon-beta production (GO:0032728)3.71369819
45regulation of MHC class I biosynthetic process (GO:0045343)3.71069186
46lipopolysaccharide-mediated signaling pathway (GO:0031663)3.69013484
47positive regulation of B cell differentiation (GO:0045579)3.68610885
48negative regulation of T cell mediated immunity (GO:0002710)3.68336548
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.67307237
50pinocytosis (GO:0006907)3.65690634
51negative T cell selection (GO:0043383)3.65545454
52detection of external biotic stimulus (GO:0098581)3.64501273
53neutrophil activation (GO:0042119)3.61242218
54cellular response to interferon-gamma (GO:0071346)3.57606518
55positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.54354601
56negative regulation of interleukin-17 production (GO:0032700)3.50979017
57response to protozoan (GO:0001562)3.50883114
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.50363399
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.50363399
60B cell homeostasis (GO:0001782)3.49603976
61antigen processing and presentation of endogenous antigen (GO:0019883)3.47449580
62cellular extravasation (GO:0045123)3.43506210
63B cell mediated immunity (GO:0019724)3.43374048
64positive regulation of humoral immune response (GO:0002922)3.36739177
65regulation of antigen processing and presentation (GO:0002577)3.36621496
66negative regulation of lymphocyte mediated immunity (GO:0002707)3.36426373
67response to type I interferon (GO:0034340)3.36252462
68type I interferon signaling pathway (GO:0060337)3.36160515
69cellular response to type I interferon (GO:0071357)3.36160515
70positive regulation of toll-like receptor signaling pathway (GO:0034123)3.33826583
71B cell receptor signaling pathway (GO:0050853)3.32333882
72response to muramyl dipeptide (GO:0032495)3.32099914
73regulation of hypersensitivity (GO:0002883)3.30018695
74myeloid dendritic cell activation (GO:0001773)3.28571244
75positive regulation of chemokine biosynthetic process (GO:0045080)3.28003492
76regulation of mast cell degranulation (GO:0043304)3.27923744
77negative regulation of granulocyte differentiation (GO:0030853)3.27889573
78detection of biotic stimulus (GO:0009595)3.27444594
79* positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.27366724
80response to interferon-gamma (GO:0034341)3.24381677
81regulation of type I interferon-mediated signaling pathway (GO:0060338)3.23218648
82regulation of interleukin-12 production (GO:0032655)3.19404663
83regulation of gamma-delta T cell differentiation (GO:0045586)3.19007733
84regulation of mononuclear cell migration (GO:0071675)3.18973813
85regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.17123802
86positive regulation of chemokine secretion (GO:0090197)3.15783419
87interferon-gamma-mediated signaling pathway (GO:0060333)3.15752289
88regulation of B cell proliferation (GO:0030888)3.15633396
89positive regulation of B cell mediated immunity (GO:0002714)3.14311536
90positive regulation of immunoglobulin mediated immune response (GO:0002891)3.14311536
91regulation of alpha-beta T cell proliferation (GO:0046640)3.14087669
92natural killer cell mediated immunity (GO:0002228)3.13609735
93natural killer cell mediated cytotoxicity (GO:0042267)3.13609735
94interferon-gamma production (GO:0032609)3.12398482
95positive regulation of type 2 immune response (GO:0002830)3.11399782
96positive regulation of B cell proliferation (GO:0030890)3.10318458
97positive regulation of mast cell activation (GO:0033005)3.10057389
98regulation of mast cell activation involved in immune response (GO:0033006)3.09997769
99cellular response to exogenous dsRNA (GO:0071360)3.09180500
100adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.09100107
101positive regulation of macrophage cytokine production (GO:0060907)3.08988662
102G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.08591831
103* I-kappaB phosphorylation (GO:0007252)3.07321695
104regulation of B cell differentiation (GO:0045577)3.07133808
105positive regulation of cellular amide metabolic process (GO:0034250)3.06198985
106negative regulation of interleukin-6 production (GO:0032715)3.05660216
107T cell selection (GO:0045058)3.05616143
108regulation of germinal center formation (GO:0002634)3.05432906
109thymic T cell selection (GO:0045061)3.05189970
110adaptive immune response (GO:0002250)3.04796573
111regulation of mast cell activation (GO:0033003)3.03377659
112negative regulation of interleukin-12 production (GO:0032695)3.01958984
113natural killer cell activation involved in immune response (GO:0002323)3.00817184
114* myeloid leukocyte activation (GO:0002274)3.00367810
115negative regulation of leukocyte mediated immunity (GO:0002704)2.99210090
116detection of molecule of bacterial origin (GO:0032490)2.98615386
117cellular response to interferon-beta (GO:0035458)2.98144332
118negative regulation of innate immune response (GO:0045824)2.98016827
119T cell costimulation (GO:0031295)2.95575843
120positive T cell selection (GO:0043368)2.95013757
121neutrophil mediated immunity (GO:0002446)2.94842881
122regulation of interleukin-12 biosynthetic process (GO:0045075)2.93344560
123response to interferon-alpha (GO:0035455)2.92126726
124germinal center formation (GO:0002467)2.91627287
125defense response to protozoan (GO:0042832)2.91611694
126negative regulation of B cell proliferation (GO:0030889)2.89980610
127negative regulation of mast cell activation (GO:0033004)2.87341225
128regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86868137
129hydrogen peroxide biosynthetic process (GO:0050665)2.82016420
130positive regulation of mast cell degranulation (GO:0043306)2.80324010
131positive regulation of mast cell activation involved in immune response (GO:0033008)2.80324010
132production of molecular mediator involved in inflammatory response (GO:0002532)2.78365527
133neutrophil chemotaxis (GO:0030593)2.78029129
134cellular response to interferon-alpha (GO:0035457)2.77756518
135regulation of leukocyte degranulation (GO:0043300)2.76334854
136mature B cell differentiation (GO:0002335)2.74913584
137* regulation of interferon-beta production (GO:0032648)2.74805203
138cytokine secretion (GO:0050663)2.73525901
139glycosphingolipid catabolic process (GO:0046479)2.71654494
140neutrophil migration (GO:1990266)2.70033669
141positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.69718176
142positive regulation of interleukin-12 production (GO:0032735)2.69483425
143* positive regulation of chemokine production (GO:0032722)2.69357728
144hyaluronan catabolic process (GO:0030214)2.69242107
145lymphocyte chemotaxis (GO:0048247)2.68948746
146positive regulation of leukocyte degranulation (GO:0043302)2.68519098
147leukocyte mediated cytotoxicity (GO:0001909)2.67715914
148mannose metabolic process (GO:0006013)2.67212827
149myeloid dendritic cell differentiation (GO:0043011)2.66878908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.03687285
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.76541305
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.48413697
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.93205259
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.53765468
6* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.98131846
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.82287438
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.70828485
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.56133445
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.46979976
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.46225344
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.26310789
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06465048
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.94336557
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.80177980
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77835008
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73470435
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.67015248
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.40744293
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.29561189
21SPI1_23547873_ChIP-Seq_NB4_Human2.24648910
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24178806
23SCL_19346495_ChIP-Seq_HPC-7_Human2.18096873
24SPI1_23127762_ChIP-Seq_K562_Human2.13014429
25PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.12142018
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.11894000
27VDR_24763502_ChIP-Seq_THP-1_Human1.96089124
28RUNX_20019798_ChIP-Seq_JUKART_Human1.95163662
29PU_27001747_Chip-Seq_BMDM_Mouse1.93594907
30VDR_21846776_ChIP-Seq_THP-1_Human1.90870350
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89597378
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.81107503
33MYB_26560356_Chip-Seq_TH2_Human1.80685156
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79394626
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78584125
36GATA1_22025678_ChIP-Seq_K562_Human1.78386398
37MAF_26560356_Chip-Seq_TH1_Human1.71916683
38VDR_24787735_ChIP-Seq_THP-1_Human1.71772791
39CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67583234
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67502247
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66818943
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66070950
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65683364
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59500925
45MYB_26560356_Chip-Seq_TH1_Human1.53478197
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53211659
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.47458409
48CIITA_25753668_ChIP-Seq_RAJI_Human1.46693274
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43391300
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42138461
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41725308
52TCF7_22412390_ChIP-Seq_EML_Mouse1.34887188
53UTX_26944678_Chip-Seq_JUKART_Human1.31316425
54GATA3_27048872_Chip-Seq_THYMUS_Human1.30678046
55MYC_22102868_ChIP-Seq_BL_Human1.30231817
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28065441
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.27215950
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27105778
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25645869
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24154216
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20942282
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18733680
63* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17253802
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16588294
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14804361
66* GATA3_26560356_Chip-Seq_TH2_Human1.11818509
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11747093
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10767732
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07859306
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.05447425
71TFEB_21752829_ChIP-Seq_HELA_Human1.05359062
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03273497
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02355947
74KDM2B_26808549_Chip-Seq_DND41_Human0.98875504
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96042035
76* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95891058
77GATA1_19941827_ChIP-Seq_MEL_Mouse0.95086531
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93878606
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93045273
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92739060
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92590204
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92468536
83MAF_26560356_Chip-Seq_TH2_Human0.90717792
84* BCL6_27268052_Chip-Seq_Bcells_Human0.90409025
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88394831
86GATA1_19941826_ChIP-Seq_K562_Human0.87568009
87GATA2_19941826_ChIP-Seq_K562_Human0.86045183
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86033399
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84560605
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84257119
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84202110
92GATA3_26560356_Chip-Seq_TH1_Human0.82712955
93* BCOR_27268052_Chip-Seq_Bcells_Human0.77229153
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77206642
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.76312204
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75140052
97* P300_27268052_Chip-Seq_Bcells_Human0.75026946
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74732798
99SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73180767
100* SPI1_20517297_ChIP-Seq_HL60_Human0.72072106
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.71800718
102EGR1_19032775_ChIP-ChIP_M12_Human0.71017058
103STAT1_20625510_ChIP-Seq_HELA_Human0.68999656
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68824498
105RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68336711
106LXR_22292898_ChIP-Seq_THP-1_Human0.66432715
107CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66254421
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.65909399
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.64248519
110IKZF1_21737484_ChIP-ChIP_HCT116_Human0.63788121
111* SMRT_27268052_Chip-Seq_Bcells_Human0.63710575
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.63198166
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.61468760
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.61071388
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.58629396
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57984316
117SOX2_20726797_ChIP-Seq_SW620_Human0.57291613
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56720380
119TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.56514336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.41541852
2MP0005058_abnormal_lysosome_morphology4.39160478
3MP0003303_peritoneal_inflammation3.79848485
4MP0006082_CNS_inflammation3.73428536
5MP0003436_decreased_susceptibility_to3.37180614
6MP0003172_abnormal_lysosome_physiology3.31069422
7* MP0002419_abnormal_innate_immunity3.10156938
8* MP0005000_abnormal_immune_tolerance2.93853835
9MP0003191_abnormal_cellular_cholesterol2.86307076
10MP0002148_abnormal_hypersensitivity_rea2.81716757
11MP0005387_immune_system_phenotype2.73558059
12MP0001790_abnormal_immune_system2.73558059
13* MP0002452_abnormal_antigen_presenting2.71533450
14MP0009785_altered_susceptibility_to2.68914601
15* MP0001800_abnormal_humoral_immune2.60984879
16MP0005025_abnormal_response_to2.58270879
17MP0005671_abnormal_response_to2.56585976
18MP0009840_abnormal_foam_cell2.50749863
19* MP0002723_abnormal_immune_serum2.47589212
20MP0002138_abnormal_hepatobiliary_system2.37040151
21MP0005464_abnormal_platelet_physiology2.36942008
22MP0000685_abnormal_immune_system2.36799999
23MP0000569_abnormal_digit_pigmentation2.29279165
24MP0003724_increased_susceptibility_to2.24744311
25* MP0001819_abnormal_immune_cell2.20288986
26* MP0002420_abnormal_adaptive_immunity2.18731453
27MP0004510_myositis2.15042519
28MP0001533_abnormal_skeleton_physiology2.06328860
29MP0003300_gastrointestinal_ulcer2.00369683
30MP0003690_abnormal_glial_cell1.86387702
31MP0002405_respiratory_system_inflammati1.82281452
32MP0001845_abnormal_inflammatory_respons1.79207797
33MP0004947_skin_inflammation1.76371398
34MP0003183_abnormal_peptide_metabolism1.75837165
35MP0001853_heart_inflammation1.74510857
36MP0000604_amyloidosis1.72811245
37MP0009278_abnormal_bone_marrow1.70120983
38MP0003075_altered_response_to1.68253893
39* MP0000716_abnormal_immune_system1.63914756
40* MP0008469_abnormal_protein_level1.63436141
41MP0000343_altered_response_to1.55524392
42MP0002398_abnormal_bone_marrow1.54612381
43* MP0000689_abnormal_spleen_morphology1.51097484
44MP0005310_abnormal_salivary_gland1.48998032
45MP0003448_altered_tumor_morphology1.48682391
46MP0002998_abnormal_bone_remodeling1.42177862
47MP0009333_abnormal_splenocyte_physiolog1.36289737
48MP0010155_abnormal_intestine_physiology1.35834899
49MP0002166_altered_tumor_susceptibility1.34647853
50* MP0002429_abnormal_blood_cell1.32590426
51MP0001348_abnormal_lacrimal_gland1.32377819
52MP0010307_abnormal_tumor_latency1.30998983
53MP0005166_decreased_susceptibility_to1.30899773
54MP0002722_abnormal_immune_system1.30697481
55MP0009764_decreased_sensitivity_to1.30335322
56MP0001851_eye_inflammation1.27997644
57MP0005174_abnormal_tail_pigmentation1.27519608
58MP0002006_tumorigenesis1.23431363
59MP0000465_gastrointestinal_hemorrhage1.21168893
60MP0005167_abnormal_blood-brain_barrier1.13797444
61MP0002163_abnormal_gland_morphology1.12667501
62MP0005451_abnormal_body_composition1.12372148
63MP0005397_hematopoietic_system_phenotyp1.08911397
64MP0001545_abnormal_hematopoietic_system1.08911397
65MP0003566_abnormal_cell_adhesion1.06155978
66MP0000858_altered_metastatic_potential1.06117098
67MP0003828_pulmonary_edema1.05425464
68MP0001873_stomach_inflammation1.03413214
69MP0002933_joint_inflammation1.02604348
70MP0002254_reproductive_system_inflammat1.00763557
71MP0000015_abnormal_ear_pigmentation1.00338643
72MP0003866_abnormal_defecation0.99692698
73MP0005257_abnormal_intraocular_pressure0.96334390
74MP0003195_calcinosis0.95716276
75MP0005645_abnormal_hypothalamus_physiol0.95627448
76MP0005390_skeleton_phenotype0.93993262
77MP0002396_abnormal_hematopoietic_system0.90143019
78MP0005164_abnormal_response_to0.87176391
79MP0002090_abnormal_vision0.86850517
80MP0001663_abnormal_digestive_system0.85303608
81MP0000249_abnormal_blood_vessel0.83959869
82MP0009763_increased_sensitivity_to0.83107977
83MP0004808_abnormal_hematopoietic_stem0.81666299
84MP0005379_endocrine/exocrine_gland_phen0.81476511
85MP0002693_abnormal_pancreas_physiology0.79087377
86MP0002277_abnormal_respiratory_mucosa0.78567906
87MP0005076_abnormal_cell_differentiation0.78033776
88MP0008438_abnormal_cutaneous_collagen0.75153389
89MP0003091_abnormal_cell_migration0.74628979
90MP0000767_abnormal_smooth_muscle0.74172885
91MP0002136_abnormal_kidney_physiology0.73680440
92MP0004883_abnormal_blood_vessel0.73283995
93MP0000371_diluted_coat_color0.73154043
94MP0008260_abnormal_autophagy0.73091330
95MP0003763_abnormal_thymus_physiology0.72087713
96MP0003045_fibrosis0.70766897
97MP0000920_abnormal_myelination0.69350665
98MP0000703_abnormal_thymus_morphology0.68590612
99MP0003656_abnormal_erythrocyte_physiolo0.68497849
100MP0001986_abnormal_taste_sensitivity0.68301266
101MP0003795_abnormal_bone_structure0.68071647
102MP0004185_abnormal_adipocyte_glucose0.67411931
103MP0002139_abnormal_hepatobiliary_system0.65492983
104MP0001915_intracranial_hemorrhage0.64498241
105MP0005023_abnormal_wound_healing0.64182533
106MP0002928_abnormal_bile_duct0.63701711
107MP0000609_abnormal_liver_physiology0.63032745
108MP0005075_abnormal_melanosome_morpholog0.62802966
109MP0000490_abnormal_crypts_of0.61628695
110MP0008004_abnormal_stomach_pH0.61572171
111MP0002332_abnormal_exercise_endurance0.61529696
112MP0003705_abnormal_hypodermis_morpholog0.61022824
113MP0001958_emphysema0.60738813
114MP0003453_abnormal_keratinocyte_physiol0.60476721
115MP0008873_increased_physiological_sensi0.58827408
116MP0008874_decreased_physiological_sensi0.57361749
117MP0004130_abnormal_muscle_cell0.55993724
118MP0004381_abnormal_hair_follicle0.55952392
119MP0003252_abnormal_bile_duct0.50498994
120MP0009115_abnormal_fat_cell0.49405244
121MP0008872_abnormal_physiological_respon0.49293950
122MP0002019_abnormal_tumor_incidence0.48549590
123MP0003806_abnormal_nucleotide_metabolis0.47663837

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.54580493
2Systemic lupus erythematosus (HP:0002725)6.45764470
3Recurrent bacterial skin infections (HP:0005406)5.98708586
4Increased cerebral lipofuscin (HP:0011813)5.93975717
5Eczematoid dermatitis (HP:0000976)5.79111765
6Increased neuronal autofluorescent lipopigment (HP:0002074)5.25401319
7Vacuolated lymphocytes (HP:0001922)5.08106539
8Abnormality of liposaccharide metabolism (HP:0010968)5.03000968
9Abnormality of glycosphingolipid metabolism (HP:0004343)5.03000968
10Abnormality of glycolipid metabolism (HP:0010969)5.03000968
11Agammaglobulinemia (HP:0004432)5.01986964
12Recurrent gram-negative bacterial infections (HP:0005420)4.88522884
13Glomerulonephritis (HP:0000099)4.79304371
14Abnormality of macrophages (HP:0004311)4.67725915
15Dysostosis multiplex (HP:0000943)4.55421585
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.38350045
17Disinhibition (HP:0000734)4.37553427
18Recurrent bronchitis (HP:0002837)4.17493901
19Recurrent sinusitis (HP:0011108)3.88320311
20Axonal loss (HP:0003447)3.83884838
21Mediastinal lymphadenopathy (HP:0100721)3.70759516
22Recurrent skin infections (HP:0001581)3.65275597
23Encephalitis (HP:0002383)3.62382716
24Mucopolysacchariduria (HP:0008155)3.62126934
25Urinary glycosaminoglycan excretion (HP:0003541)3.62126934
26Lymphopenia (HP:0001888)3.58540768
27Elevated erythrocyte sedimentation rate (HP:0003565)3.53873150
28Autoimmune thrombocytopenia (HP:0001973)3.52341246
29Abnormality of polysaccharide metabolism (HP:0011012)3.47296822
30Abnormality of glycosaminoglycan metabolism (HP:0004371)3.47296822
31Abnormality of mucopolysaccharide metabolism (HP:0011020)3.47296822
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.46968326
33Panhypogammaglobulinemia (HP:0003139)3.46742492
34Abnormality of cells of the lymphoid lineage (HP:0012140)3.38509587
35IgA deficiency (HP:0002720)3.37382496
36Increased IgM level (HP:0003496)3.28252261
37Gingivitis (HP:0000230)3.27730930
38Complement deficiency (HP:0004431)3.25468092
39Myositis (HP:0100614)3.24893950
40Chronic obstructive pulmonary disease (HP:0006510)3.23181014
41Obstructive lung disease (HP:0006536)3.23181014
42Recurrent fungal infections (HP:0002841)3.22450200
43Hematochezia (HP:0002573)3.20269052
44Agnosia (HP:0010524)3.12810800
45IgG deficiency (HP:0004315)3.09528910
46Recurrent viral infections (HP:0004429)3.05837182
47Gastrointestinal infarctions (HP:0005244)3.04899660
48Loss of speech (HP:0002371)3.04673119
49Stomatitis (HP:0010280)2.99450394
50Keratoconjunctivitis sicca (HP:0001097)2.99106354
51IgM deficiency (HP:0002850)2.96951082
52Colitis (HP:0002583)2.96155337
53Cellulitis (HP:0100658)2.94662801
54Abnormality of T cell physiology (HP:0011840)2.93531612
55Hemoptysis (HP:0002105)2.92714129
56Nephritis (HP:0000123)2.88086712
57Myocardial infarction (HP:0001658)2.87732686
58Basal ganglia calcification (HP:0002135)2.85492623
59Keratoconjunctivitis (HP:0001096)2.84213833
60Abnormality of T cells (HP:0002843)2.83509355
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.80195567
62Abnormality of complement system (HP:0005339)2.80190051
63Orchitis (HP:0100796)2.79758144
64Mutism (HP:0002300)2.76911942
65Vasculitis (HP:0002633)2.76443826
66Interstitial pulmonary disease (HP:0006530)2.75528755
67Abnormality of T cell number (HP:0011839)2.75017818
68Hepatosplenomegaly (HP:0001433)2.70613796
69Upper motor neuron abnormality (HP:0002127)2.70355414
70Increased IgE level (HP:0003212)2.69484060
71Restrictive lung disease (HP:0002091)2.68218301
72Retinal atrophy (HP:0001105)2.65985747
73Papilloma (HP:0012740)2.61800740
74Verrucae (HP:0200043)2.61800740
75Inflammation of the large intestine (HP:0002037)2.60847177
76Prostate neoplasm (HP:0100787)2.60652695
77Emphysema (HP:0002097)2.59680298
78Osteomyelitis (HP:0002754)2.57837903
79T lymphocytopenia (HP:0005403)2.52618620
80Pustule (HP:0200039)2.50524687
81Abnormality of B cell number (HP:0010975)2.44194935
82Global brain atrophy (HP:0002283)2.43896031
83Periodontitis (HP:0000704)2.43892700
84Thick nail (HP:0001805)2.43522161
85Sepsis (HP:0100806)2.43403698
86Gastrointestinal inflammation (HP:0004386)2.42521977
87Retrobulbar optic neuritis (HP:0100654)2.41821946
88Optic neuritis (HP:0100653)2.41821946
89Recurrent cutaneous fungal infections (HP:0011370)2.40705731
90Chronic mucocutaneous candidiasis (HP:0002728)2.40705731
91Arterial tortuosity (HP:0005116)2.39184699
92Pathologic fracture (HP:0002756)2.38205440
93Chronic otitis media (HP:0000389)2.36800525
94Neuronal loss in central nervous system (HP:0002529)2.35535056
95Inappropriate behavior (HP:0000719)2.35161336
96Spontaneous hematomas (HP:0007420)2.34662173
97Chest pain (HP:0100749)2.33701590
98Hypergammaglobulinemia (HP:0010702)2.32812355
99Cerebral aneurysm (HP:0004944)2.31268809
100Bronchitis (HP:0012387)2.30919832
101Skin rash (HP:0000988)2.30411703
102Abnormality of the pleura (HP:0002103)2.28455532
103Recurrent pneumonia (HP:0006532)2.26762843
104Meningitis (HP:0001287)2.25885571
105Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25427949
106Chronic sinusitis (HP:0011109)2.22662638
107Thoracic kyphosis (HP:0002942)2.22108183
108Osteolytic defects of the hand bones (HP:0009699)2.20392146
109Osteolytic defects of the phalanges of the hand (HP:0009771)2.20392146
110Arthralgia (HP:0002829)2.19858660
111Autoimmune hemolytic anemia (HP:0001890)2.19263298
112Pulmonary infiltrates (HP:0002113)2.18941842
113Urticaria (HP:0001025)2.18815257
114B lymphocytopenia (HP:0010976)2.18711922
115Peripheral demyelination (HP:0011096)2.16726603
116Gangrene (HP:0100758)2.13587989
117Cheilitis (HP:0100825)2.13226906
118Leukopenia (HP:0001882)2.12196095
119J-shaped sella turcica (HP:0002680)2.11305558
120Granulocytopenia (HP:0001913)2.11181033
121Abnormality of the prostate (HP:0008775)2.10609611
122Leukocytosis (HP:0001974)2.08617330
123Abnormality of eosinophils (HP:0001879)2.08194608
124Pulmonary embolism (HP:0002204)2.07475013
125Anorexia (HP:0002039)2.06958057
126Asymmetric septal hypertrophy (HP:0001670)2.06109351
127Vascular tortuosity (HP:0004948)2.04307598
128Lymphoma (HP:0002665)2.03960998
129Chronic diarrhea (HP:0002028)2.02602896
130Polyneuropathy (HP:0001271)2.02120708
131Increased CSF protein (HP:0002922)2.01037360
132Bone pain (HP:0002653)2.00995492
133Conjunctival telangiectasia (HP:0000524)2.00939126
134Diminished motivation (HP:0000745)2.00467274
135Abnormality of the lumbar spine (HP:0100712)2.00171836
136Apathy (HP:0000741)1.99539887
137Arterial thrombosis (HP:0004420)1.98910470
138Spondylolisthesis (HP:0003302)1.98761793
139Progressive visual loss (HP:0000529)1.95378841
140Recurrent lower respiratory tract infections (HP:0002783)1.94169742
141Progressive neurologic deterioration (HP:0002344)1.92943916
142Gingival bleeding (HP:0000225)1.90263001
143Personality changes (HP:0000751)1.88317716
144Tetraparesis (HP:0002273)1.86473108
145Gastrointestinal stroma tumor (HP:0100723)1.85372170
146Eosinophilia (HP:0001880)1.83953707
147Petechiae (HP:0000967)1.82131488

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.22594837
2BLK3.93804659
3TYK23.57901587
4RIPK43.39169956
5MAP4K13.37243801
6TBK13.08067516
7CSF1R2.80938842
8ERN12.78448644
9IRAK42.77871224
10KIT2.74147837
11MAP3K142.64948913
12PRPF4B2.27923706
13JAK12.24541953
14IRAK32.12828817
15CAMK1D1.95605202
16IKBKE1.93764585
17IKBKB1.80812140
18ZAP701.75420677
19GRK71.71467566
20HCK1.66548377
21STK101.63711885
22TXK1.61508483
23SYK1.61003969
24CSK1.59906544
25MAP3K131.58872107
26FES1.58414773
27JAK31.54623864
28CAMK1G1.37070349
29NEK91.36143627
30LYN1.33600828
31MAPK151.32437066
32TAOK31.25442110
33LCK1.25336597
34EPHB11.25294209
35MATK1.24088170
36FGR1.21338920
37BTK1.20402629
38TNK21.19326785
39ITK1.18596278
40SIK31.15148501
41SIK21.14418142
42SCYL21.14097889
43MAP2K31.12072960
44JAK21.11210423
45TLK11.09506226
46TRIB31.07549380
47FRK1.06757765
48MAP3K101.01975983
49CLK11.00056231
50MARK30.97154720
51PAK40.94471947
52PBK0.92924908
53TEC0.90085109
54RPS6KA40.87030721
55CDC42BPA0.87004695
56PKN20.86237528
57CHUK0.85223651
58CAMKK20.84674607
59RIPK10.82595703
60EGFR0.75779232
61FGFR30.73634663
62PTK60.72990356
63FGFR40.71981288
64GRK60.71526573
65PIM20.68545302
66CDK120.68068424
67PIM10.68044576
68LRRK20.67673042
69MOS0.67580021
70ACVR1B0.67164900
71TTN0.66738982
72MAP3K30.62929969
73MAPK110.62784352
74CDK60.60395522
75ABL10.59896325
76MAP3K10.58861022
77PRKCD0.58404883
78CDK40.57769195
79STK40.57318143
80PDK10.54180630
81MAPK120.50190474
82CCNB10.49857620
83TRPM70.49739201
84CAMKK10.47200279
85FYN0.45273961
86CDK190.45235197
87HIPK20.44589839
88IGF1R0.43450295
89ADRBK20.43280957
90MAPKAPK20.42887901
91PDPK10.42644290
92STK240.42486106
93BMX0.41859653
94PRKCH0.41666810
95BMPR20.40837826
96MELK0.40495587
97KSR20.39598645
98PRKCQ0.39536432
99EIF2AK20.39367379
100RPS6KA50.39096299
101MAP3K50.38544624
102IRAK10.38413093
103YES10.35942277
104INSR0.35559696
105TAOK10.35167410
106MAPK70.35114845
107OXSR10.34771781
108TAOK20.34286696
109PIK3CG0.34235253
110IRAK20.33401496
111EIF2AK30.32877088
112PKN10.32461111
113GSK3A0.31562224
114NME20.30900783
115PDGFRB0.30699961
116PASK0.29724664
117ABL20.28723483
118EPHA30.28679930
119MAP3K110.28644395
120STK110.26872738
121DAPK20.26308940
122PRKCZ0.25379683
123MAP2K10.25037041
124STK30.24978731
125SMG10.24963837
126NLK0.24621006
127MAP3K90.24580272
128MAPK40.24488423
129RAF10.23861903
130SGK20.23722230
131MAP3K80.21251062
132SRC0.20764667

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.85780114
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.55967837
3Leishmaniasis_Homo sapiens_hsa051403.14401070
4Lysosome_Homo sapiens_hsa041423.08182560
5Other glycan degradation_Homo sapiens_hsa005112.94557279
6Osteoclast differentiation_Homo sapiens_hsa043802.85400777
7* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.55432750
8B cell receptor signaling pathway_Homo sapiens_hsa046622.43113267
9Pertussis_Homo sapiens_hsa051332.32183792
10Tuberculosis_Homo sapiens_hsa051522.23598708
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.17216154
12Legionellosis_Homo sapiens_hsa051341.96638707
13Antigen processing and presentation_Homo sapiens_hsa046121.95434912
14Malaria_Homo sapiens_hsa051441.89604324
15Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.82241758
16* Measles_Homo sapiens_hsa051621.80466097
17Phagosome_Homo sapiens_hsa041451.75210947
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74328954
19Rheumatoid arthritis_Homo sapiens_hsa053231.73586162
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70303204
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69328538
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67989360
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.67940043
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66141201
25Graft-versus-host disease_Homo sapiens_hsa053321.60986912
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59242933
27Hematopoietic cell lineage_Homo sapiens_hsa046401.58630133
28* Influenza A_Homo sapiens_hsa051641.58413738
29Toxoplasmosis_Homo sapiens_hsa051451.56586388
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49483916
31Salmonella infection_Homo sapiens_hsa051321.41735852
32TNF signaling pathway_Homo sapiens_hsa046681.37362600
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.35387810
34Chemokine signaling pathway_Homo sapiens_hsa040621.34330040
35Allograft rejection_Homo sapiens_hsa053301.32936770
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32907925
37Apoptosis_Homo sapiens_hsa042101.28873721
38Herpes simplex infection_Homo sapiens_hsa051681.23730345
39Primary immunodeficiency_Homo sapiens_hsa053401.16213288
40Shigellosis_Homo sapiens_hsa051311.12193498
41Asthma_Homo sapiens_hsa053101.11806233
42Hepatitis B_Homo sapiens_hsa051611.11383507
43African trypanosomiasis_Homo sapiens_hsa051431.11152133
44Complement and coagulation cascades_Homo sapiens_hsa046101.11129949
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08132282
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.05285249
47Prion diseases_Homo sapiens_hsa050201.05142237
48T cell receptor signaling pathway_Homo sapiens_hsa046601.00513588
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.97447161
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97322316
51Hepatitis C_Homo sapiens_hsa051600.94369083
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92635769
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91355715
54Chronic myeloid leukemia_Homo sapiens_hsa052200.90592462
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89636632
56Pancreatic cancer_Homo sapiens_hsa052120.86729943
57Caffeine metabolism_Homo sapiens_hsa002320.82617379
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82020008
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80608037
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78201882
61Platelet activation_Homo sapiens_hsa046110.77420696
62Viral myocarditis_Homo sapiens_hsa054160.76981418
63Acute myeloid leukemia_Homo sapiens_hsa052210.73507396
64Amoebiasis_Homo sapiens_hsa051460.71649043
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.70056276
66Endocytosis_Homo sapiens_hsa041440.69759499
67Type I diabetes mellitus_Homo sapiens_hsa049400.69425825
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.58010805
69Collecting duct acid secretion_Homo sapiens_hsa049660.56509543
70Sphingolipid metabolism_Homo sapiens_hsa006000.53658513
71Epstein-Barr virus infection_Homo sapiens_hsa051690.51019638
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50923466
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47348741
74Notch signaling pathway_Homo sapiens_hsa043300.46365557
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45021494
76Viral carcinogenesis_Homo sapiens_hsa052030.43949761
77Type II diabetes mellitus_Homo sapiens_hsa049300.43577036
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43207497
79Renin-angiotensin system_Homo sapiens_hsa046140.42783681
80VEGF signaling pathway_Homo sapiens_hsa043700.42423903
81Renal cell carcinoma_Homo sapiens_hsa052110.42252293
82HIF-1 signaling pathway_Homo sapiens_hsa040660.42064272
83Systemic lupus erythematosus_Homo sapiens_hsa053220.41275033
84Prolactin signaling pathway_Homo sapiens_hsa049170.40845948
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.37656380
86Proteoglycans in cancer_Homo sapiens_hsa052050.35432204
87Colorectal cancer_Homo sapiens_hsa052100.35269299
88Autoimmune thyroid disease_Homo sapiens_hsa053200.33118193
89ABC transporters_Homo sapiens_hsa020100.32734043
90Mineral absorption_Homo sapiens_hsa049780.31706204
91Small cell lung cancer_Homo sapiens_hsa052220.31524349
92Ether lipid metabolism_Homo sapiens_hsa005650.29769012
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28767576
94Dorso-ventral axis formation_Homo sapiens_hsa043200.28357249
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28299606
96Non-small cell lung cancer_Homo sapiens_hsa052230.27135468
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27045808
98Insulin resistance_Homo sapiens_hsa049310.26217212
99HTLV-I infection_Homo sapiens_hsa051660.26009644
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24811793
101mTOR signaling pathway_Homo sapiens_hsa041500.23885608
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23154834
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22775302
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.22351620
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21793237
106MAPK signaling pathway_Homo sapiens_hsa040100.21763000
107FoxO signaling pathway_Homo sapiens_hsa040680.20236643
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19305921
109GnRH signaling pathway_Homo sapiens_hsa049120.08061742
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07361068
111Prostate cancer_Homo sapiens_hsa052150.04561267
112Regulation of autophagy_Homo sapiens_hsa041400.03000747
113Linoleic acid metabolism_Homo sapiens_hsa005910.02951445
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.02667176
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.02293902
116p53 signaling pathway_Homo sapiens_hsa04115-0.0222963

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