TLR10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)7.26434325
2B cell receptor signaling pathway (GO:0050853)6.33563965
3positive regulation of gamma-delta T cell activation (GO:0046645)5.57070112
4immunoglobulin mediated immune response (GO:0016064)5.50912906
5antigen processing and presentation of endogenous antigen (GO:0019883)4.90973355
6positive regulation by symbiont of host defense response (GO:0052509)4.90323469
7modulation by symbiont of host defense response (GO:0052031)4.90323469
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.90323469
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.90323469
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.90323469
11modulation by symbiont of host immune response (GO:0052553)4.90323469
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.86130054
13B cell proliferation (GO:0042100)4.69807191
14B cell mediated immunity (GO:0019724)4.59916153
15interferon-gamma-mediated signaling pathway (GO:0060333)4.44689283
16regulation of interferon-beta biosynthetic process (GO:0045357)4.35256446
17regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.31799571
18positive regulation of B cell differentiation (GO:0045579)4.24384058
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.19435927
20regulation of B cell differentiation (GO:0045577)4.11784953
21regulation of antigen processing and presentation (GO:0002577)4.10081786
22positive thymic T cell selection (GO:0045059)4.09559099
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.08614321
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.03796887
25negative regulation of cell killing (GO:0031342)4.02409876
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02409876
27positive regulation of interferon-alpha production (GO:0032727)4.01963515
28macrophage activation involved in immune response (GO:0002281)4.00961754
29negative thymic T cell selection (GO:0045060)3.98382162
30regulation of gamma-delta T cell activation (GO:0046643)3.93513797
31B cell homeostasis (GO:0001782)3.90476938
32CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.88743255
33regulation of alpha-beta T cell proliferation (GO:0046640)3.85922041
34regulation of interferon-alpha production (GO:0032647)3.84566126
35detection of bacterium (GO:0016045)3.82027106
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81495341
37negative regulation of B cell proliferation (GO:0030889)3.79409635
38regulation of dendritic cell antigen processing and presentation (GO:0002604)3.77277040
39negative T cell selection (GO:0043383)3.77191165
40detection of other organism (GO:0098543)3.67363341
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.66703415
42regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.65136065
43positive regulation of antigen processing and presentation (GO:0002579)3.63836705
44antigen receptor-mediated signaling pathway (GO:0050851)3.63062288
45regulation of germinal center formation (GO:0002634)3.62497997
46type I interferon signaling pathway (GO:0060337)3.61755714
47cellular response to type I interferon (GO:0071357)3.61755714
48response to type I interferon (GO:0034340)3.61016656
49T cell migration (GO:0072678)3.59324753
50regulation of B cell proliferation (GO:0030888)3.57819882
51positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.55440337
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.55221535
53response to host immune response (GO:0052572)3.55221535
54defense response to protozoan (GO:0042832)3.48555733
55T cell costimulation (GO:0031295)3.47052698
56lymphocyte costimulation (GO:0031294)3.42619568
57T-helper 1 type immune response (GO:0042088)3.42481283
58positive regulation of alpha-beta T cell proliferation (GO:0046641)3.41987727
59cytidine metabolic process (GO:0046087)3.40640384
60cytidine catabolic process (GO:0006216)3.40640384
61cytidine deamination (GO:0009972)3.40640384
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.37240868
63positive T cell selection (GO:0043368)3.36748748
64microglial cell activation (GO:0001774)3.32875327
65cellular response to interleukin-15 (GO:0071350)3.31679593
66cellular response to interferon-gamma (GO:0071346)3.31662877
67mature B cell differentiation (GO:0002335)3.27030087
68positive regulation of humoral immune response (GO:0002922)3.26291137
69response to interleukin-15 (GO:0070672)3.25781457
70regulation of gamma-delta T cell differentiation (GO:0045586)3.23893773
71positive regulation of B cell proliferation (GO:0030890)3.21816597
72detection of external biotic stimulus (GO:0098581)3.21658484
73pyrimidine ribonucleoside catabolic process (GO:0046133)3.16557998
74response to host (GO:0075136)3.14744397
75response to host defenses (GO:0052200)3.14744397
76response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14744397
77response to protozoan (GO:0001562)3.13218407
78mast cell activation (GO:0045576)3.11022235
79lymphocyte proliferation (GO:0046651)3.10229200
80positive regulation of B cell activation (GO:0050871)3.07019626
81regulation of interferon-gamma biosynthetic process (GO:0045072)3.06985659
82regulation of T-helper 1 cell differentiation (GO:0045625)3.05871652
83germinal center formation (GO:0002467)3.04849054
84mononuclear cell proliferation (GO:0032943)3.04129813
85positive regulation of interferon-beta production (GO:0032728)3.03873565
86negative regulation of calcium ion transport into cytosol (GO:0010523)3.02795096
87T cell selection (GO:0045058)3.02564113
88adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.00965021
89NIK/NF-kappaB signaling (GO:0038061)2.99053956
90thymic T cell selection (GO:0045061)2.96944946
91myeloid cell activation involved in immune response (GO:0002275)2.95857190
92regulation of interferon-beta production (GO:0032648)2.95049619
93B cell activation (GO:0042113)2.93553971
94positive regulation of immunoglobulin mediated immune response (GO:0002891)2.93199815
95positive regulation of B cell mediated immunity (GO:0002714)2.93199815
96detection of molecule of bacterial origin (GO:0032490)2.92925403
97regulation of B cell activation (GO:0050864)2.91366558
98regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.89116124
99response to interferon-gamma (GO:0034341)2.89104000
100positive regulation of interferon-gamma production (GO:0032729)2.88361602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.81349112
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.18166259
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.17600278
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.03891115
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.73898715
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.60802405
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.22395992
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.18877723
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.66160076
10MYB_26560356_Chip-Seq_TH2_Human2.63948637
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.61588327
12RUNX_20019798_ChIP-Seq_JUKART_Human2.52274298
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.51500780
14MYC_22102868_ChIP-Seq_BL_Human2.49434034
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29681409
16CIITA_25753668_ChIP-Seq_RAJI_Human2.28210381
17SPI1_23547873_ChIP-Seq_NB4_Human2.24082843
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.18342688
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16902086
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12375647
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12259968
22MYB_26560356_Chip-Seq_TH1_Human2.10005372
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03991882
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95469732
25GATA3_27048872_Chip-Seq_THYMUS_Human1.89847884
26* GATA3_26560356_Chip-Seq_TH2_Human1.89114592
27SCL_19346495_ChIP-Seq_HPC-7_Human1.88850257
28EZH2_22144423_ChIP-Seq_EOC_Human1.82737627
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82536431
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.82404645
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.70953094
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68392976
33MAF_26560356_Chip-Seq_TH1_Human1.67683334
34GATA1_22025678_ChIP-Seq_K562_Human1.65048917
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59822265
36ZNF274_21170338_ChIP-Seq_K562_Hela1.59207969
37VDR_23849224_ChIP-Seq_CD4+_Human1.57476408
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44771896
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42001288
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40952512
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.40806362
42SMRT_27268052_Chip-Seq_Bcells_Human1.40031035
43IRF1_19129219_ChIP-ChIP_H3396_Human1.39996017
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37905650
45VDR_24763502_ChIP-Seq_THP-1_Human1.33100928
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32922568
47SPI1_23127762_ChIP-Seq_K562_Human1.30350976
48VDR_24787735_ChIP-Seq_THP-1_Human1.26590827
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24510653
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23786154
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23654526
52UTX_26944678_Chip-Seq_JUKART_Human1.23460504
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21433158
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20372753
55FOXP3_21729870_ChIP-Seq_TREG_Human1.18122675
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17866638
57VDR_21846776_ChIP-Seq_THP-1_Human1.13082445
58* GATA3_26560356_Chip-Seq_TH1_Human1.10058311
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07424784
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05831150
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05642215
62MAF_26560356_Chip-Seq_TH2_Human1.04771871
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02967432
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00726489
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98078497
66NFE2_27457419_Chip-Seq_LIVER_Mouse0.97419935
67FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96737996
68RUNX1_22412390_ChIP-Seq_EML_Mouse0.95755117
69GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95728664
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95572818
71EST1_17652178_ChIP-ChIP_JURKAT_Human0.94320912
72SMAD_19615063_ChIP-ChIP_OVARY_Human0.93683095
73P300_27268052_Chip-Seq_Bcells_Human0.93382101
74E2F4_17652178_ChIP-ChIP_JURKAT_Human0.92941879
75PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92342182
76PRDM14_20953172_ChIP-Seq_ESCs_Human0.91161660
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88512095
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87315873
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87149211
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85277070
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85192926
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84513785
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.84513785
84* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.83526626
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83229616
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83227033
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82975868
88BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82708676
89TP53_22573176_ChIP-Seq_HFKS_Human0.82667647
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81027282
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80662607
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80554138
93PU_27001747_Chip-Seq_BMDM_Mouse0.79784595
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79595357
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79105623
96EWS_26573619_Chip-Seq_HEK293_Human0.79014795
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.78979435
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77975708
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77687971
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77036160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.83998707
2MP0000685_abnormal_immune_system4.41225377
3MP0005671_abnormal_response_to4.26519907
4MP0001800_abnormal_humoral_immune4.14138374
5MP0005387_immune_system_phenotype4.00584800
6MP0001790_abnormal_immune_system4.00584800
7MP0005000_abnormal_immune_tolerance3.22763881
8MP0002452_abnormal_antigen_presenting3.13761498
9MP0002723_abnormal_immune_serum3.04168670
10MP0003763_abnormal_thymus_physiology2.83044294
11MP0002420_abnormal_adaptive_immunity2.81034771
12MP0001819_abnormal_immune_cell2.76095171
13MP0002138_abnormal_hepatobiliary_system2.67921591
14MP0003303_peritoneal_inflammation2.65775362
15MP0003724_increased_susceptibility_to2.53964463
16MP0009785_altered_susceptibility_to2.43271807
17MP0005645_abnormal_hypothalamus_physiol2.41318889
18MP0002398_abnormal_bone_marrow2.36435706
19MP0003436_decreased_susceptibility_to2.32688482
20MP0005025_abnormal_response_to2.31926738
21MP0000716_abnormal_immune_system2.28148874
22MP0002419_abnormal_innate_immunity2.17896461
23MP0002148_abnormal_hypersensitivity_rea2.16880269
24MP0002166_altered_tumor_susceptibility2.13033762
25MP0000689_abnormal_spleen_morphology2.04224114
26MP0005310_abnormal_salivary_gland1.96344381
27MP0003183_abnormal_peptide_metabolism1.85867714
28MP0002429_abnormal_blood_cell1.78559633
29MP0008057_abnormal_DNA_replication1.68930663
30MP0001845_abnormal_inflammatory_respons1.68850520
31MP0002722_abnormal_immune_system1.67654074
32MP0010155_abnormal_intestine_physiology1.60921194
33MP0002405_respiratory_system_inflammati1.58286031
34MP0008877_abnormal_DNA_methylation1.58209862
35MP0001986_abnormal_taste_sensitivity1.57976772
36MP0002006_tumorigenesis1.52283260
37MP0001873_stomach_inflammation1.44880448
38MP0005075_abnormal_melanosome_morpholog1.44706378
39MP0002396_abnormal_hematopoietic_system1.42985739
40MP0000703_abnormal_thymus_morphology1.38087853
41MP0005464_abnormal_platelet_physiology1.32837533
42MP0000569_abnormal_digit_pigmentation1.32818347
43MP0002163_abnormal_gland_morphology1.31821193
44MP0003045_fibrosis1.24109297
45MP0009764_decreased_sensitivity_to1.23811939
46MP0000372_irregular_coat_pigmentation1.21281455
47MP0009333_abnormal_splenocyte_physiolog1.19027228
48MP0003787_abnormal_imprinting1.18809186
49MP0003866_abnormal_defecation1.17444859
50MP0008872_abnormal_physiological_respon1.17331072
51MP0002928_abnormal_bile_duct1.13474820
52MP0008469_abnormal_protein_level1.10592216
53MP0006082_CNS_inflammation1.03809516
54MP0003252_abnormal_bile_duct1.01510965
55MP0005084_abnormal_gallbladder_morpholo1.01080004
56MP0003646_muscle_fatigue0.95555784
57MP0000465_gastrointestinal_hemorrhage0.91266695
58MP0002009_preneoplasia0.90426220
59MP0001533_abnormal_skeleton_physiology0.88590025
60MP0003300_gastrointestinal_ulcer0.88274639
61MP0002693_abnormal_pancreas_physiology0.88161621
62MP0000015_abnormal_ear_pigmentation0.87923711
63MP0004381_abnormal_hair_follicle0.87617098
64MP0005379_endocrine/exocrine_gland_phen0.86723867
65MP0001663_abnormal_digestive_system0.85102087
66MP0002019_abnormal_tumor_incidence0.83030734
67MP0001348_abnormal_lacrimal_gland0.82629458
68MP0010094_abnormal_chromosome_stability0.82277207
69MP0003195_calcinosis0.75818929
70MP0000371_diluted_coat_color0.75076757
71MP0002277_abnormal_respiratory_mucosa0.72600863
72MP0005174_abnormal_tail_pigmentation0.71925853
73MP0004947_skin_inflammation0.70366970
74MP0002136_abnormal_kidney_physiology0.68493428
75MP0001853_heart_inflammation0.61359383
76MP0002095_abnormal_skin_pigmentation0.59229306
77MP0004883_abnormal_blood_vessel0.59020668
78MP0005166_decreased_susceptibility_to0.57802337
79MP0004145_abnormal_muscle_electrophysio0.57073092
80MP0009763_increased_sensitivity_to0.56130603
81MP0008058_abnormal_DNA_repair0.55842134
82MP0001919_abnormal_reproductive_system0.52556803
83MP0000249_abnormal_blood_vessel0.52348686
84MP0002132_abnormal_respiratory_system0.51957535
85MP0002876_abnormal_thyroid_physiology0.51466154
86MP0004808_abnormal_hematopoietic_stem0.51098910
87MP0008961_abnormal_basal_metabolism0.50694521
88MP0002933_joint_inflammation0.48544405
89MP0000490_abnormal_crypts_of0.48033323
90MP0008874_decreased_physiological_sensi0.46546203
91MP0004142_abnormal_muscle_tone0.46395422
92MP0001545_abnormal_hematopoietic_system0.45086321
93MP0005397_hematopoietic_system_phenotyp0.45086321
94MP0006035_abnormal_mitochondrial_morpho0.44693759
95MP0003172_abnormal_lysosome_physiology0.44626639
96MP0005167_abnormal_blood-brain_barrier0.43804916
97MP0000427_abnormal_hair_cycle0.43556357
98MP0005220_abnormal_exocrine_pancreas0.43471846
99MP0005551_abnormal_eye_electrophysiolog0.43245478
100MP0003786_premature_aging0.41509915

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.51556795
2Gastrointestinal stroma tumor (HP:0100723)6.34072204
3Recurrent sinusitis (HP:0011108)5.01572687
4Panhypogammaglobulinemia (HP:0003139)4.86784303
5Meningitis (HP:0001287)4.83964440
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.83053532
7Recurrent bronchitis (HP:0002837)4.81026583
8Vasculitis (HP:0002633)4.71058833
9Lymphopenia (HP:0001888)4.38910122
10Recurrent cutaneous fungal infections (HP:0011370)4.23265607
11Chronic mucocutaneous candidiasis (HP:0002728)4.23265607
12Abnormality of cells of the lymphoid lineage (HP:0012140)4.03545007
13Mediastinal lymphadenopathy (HP:0100721)3.99306381
14IgG deficiency (HP:0004315)3.79467022
15Recurrent fungal infections (HP:0002841)3.78095738
16Recurrent viral infections (HP:0004429)3.76345877
17IgM deficiency (HP:0002850)3.72280509
18IgA deficiency (HP:0002720)3.64094400
19Recurrent bacterial skin infections (HP:0005406)3.56842634
20Encephalitis (HP:0002383)3.45969549
21Abnormality of T cell physiology (HP:0011840)3.35840050
22Colitis (HP:0002583)3.31995682
23Retrobulbar optic neuritis (HP:0100654)3.25072221
24Optic neuritis (HP:0100653)3.25072221
25Pulmonary infiltrates (HP:0002113)3.23568091
26Cellulitis (HP:0100658)3.21541853
27Emphysema (HP:0002097)3.20924527
28Papilloma (HP:0012740)3.19265877
29Verrucae (HP:0200043)3.19265877
30Recurrent abscess formation (HP:0002722)3.15400394
31Recurrent pneumonia (HP:0006532)3.13295131
32Restrictive lung disease (HP:0002091)3.12701721
33Abnormality of T cells (HP:0002843)3.09297752
34Recurrent skin infections (HP:0001581)3.07029259
35Abnormality of the prostate (HP:0008775)3.03544524
36Inflammation of the large intestine (HP:0002037)3.02632669
37Recurrent lower respiratory tract infections (HP:0002783)2.97533443
38Abnormality of B cell number (HP:0010975)2.95325427
39Chronic diarrhea (HP:0002028)2.94442770
40Chronic sinusitis (HP:0011109)2.94118736
41Chronic otitis media (HP:0000389)2.88385995
42Bronchitis (HP:0012387)2.84542307
43Gastrointestinal infarctions (HP:0005244)2.80741156
44Orchitis (HP:0100796)2.78076062
45Gastrointestinal inflammation (HP:0004386)2.77900412
46B lymphocytopenia (HP:0010976)2.77851726
47Osteomyelitis (HP:0002754)2.75340185
48Myositis (HP:0100614)2.74932601
49Eczematoid dermatitis (HP:0000976)2.71683305
50Elevated erythrocyte sedimentation rate (HP:0003565)2.65534815
51Hemoptysis (HP:0002105)2.63364178
52Lymphoma (HP:0002665)2.62574719
53Abnormality of T cell number (HP:0011839)2.57143883
54Chronic obstructive pulmonary disease (HP:0006510)2.54786860
55Obstructive lung disease (HP:0006536)2.54786860
56Chest pain (HP:0100749)2.50674976
57Abnormality of the pleura (HP:0002103)2.47565893
58Skin rash (HP:0000988)2.45637583
59Viral hepatitis (HP:0006562)2.44605972
60Urticaria (HP:0001025)2.41979215
61Stomatitis (HP:0010280)2.41669740
62Leukopenia (HP:0001882)2.41367267
63T lymphocytopenia (HP:0005403)2.39139883
64Keratoconjunctivitis (HP:0001096)2.35389393
65Recurrent otitis media (HP:0000403)2.33950359
66Keratoconjunctivitis sicca (HP:0001097)2.32473063
67Sepsis (HP:0100806)2.31771943
68Increased IgM level (HP:0003496)2.29962196
69Neutropenia (HP:0001875)2.29740383
70Recurrent gram-negative bacterial infections (HP:0005420)2.16696082
71Congenital stationary night blindness (HP:0007642)2.13586760
72Abnormality of male internal genitalia (HP:0000022)2.06763606
73Severe combined immunodeficiency (HP:0004430)2.01798131
74Abnormality of macrophages (HP:0004311)1.99325812
75Arterial thrombosis (HP:0004420)1.98057543
76Stomach cancer (HP:0012126)1.94911071
77Gangrene (HP:0100758)1.92783426
78Spontaneous hematomas (HP:0007420)1.90954833
79Arthralgia (HP:0002829)1.89707889
80Autoimmune hemolytic anemia (HP:0001890)1.87801533
81Thyroiditis (HP:0100646)1.87703532
82Basal cell carcinoma (HP:0002671)1.86545671
83Pulmonary embolism (HP:0002204)1.84233735
84Xerostomia (HP:0000217)1.83849670
85Bronchiectasis (HP:0002110)1.80604150
86Eosinophilia (HP:0001880)1.79340399
87Autoimmune thrombocytopenia (HP:0001973)1.78887865
88Hypoplasia of the thymus (HP:0000778)1.77244144
89Leukocytosis (HP:0001974)1.76338857
90Abnormality of eosinophils (HP:0001879)1.75569966
91Acute hepatic failure (HP:0006554)1.75401267
92Pulmonary fibrosis (HP:0002206)1.73860965
93Anorexia (HP:0002039)1.71438887
94Keratitis (HP:0000491)1.67534921
95Granulocytopenia (HP:0001913)1.67133244
96Increased IgE level (HP:0003212)1.66490369
97Amaurosis fugax (HP:0100576)1.66277628
98Attenuation of retinal blood vessels (HP:0007843)1.65532026
99Skin ulcer (HP:0200042)1.64645521
100Pustule (HP:0200039)1.64505571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.70351562
2MAP4K14.60869840
3CDK193.10160717
4BLK3.04143294
5SYK2.91498443
6IRAK42.74163483
7FRK2.51629463
8BTK2.31670143
9BMPR22.28484109
10MAP3K142.15399358
11IKBKE2.14730966
12CSF1R2.05282092
13EIF2AK32.04276657
14TEC2.01799526
15TAOK31.88951055
16LYN1.84512776
17IKBKB1.75370152
18TYK21.75118510
19TXK1.75044921
20KIT1.74516198
21JAK31.73639598
22ITK1.61839709
23ERN11.57348399
24SIK21.49560592
25MAP3K131.41114009
26TLK11.38941528
27ZAK1.38363979
28STK241.34036685
29PRKCQ1.33830868
30JAK11.32898001
31TBK11.29884042
32NEK91.25304154
33MST41.23445109
34PASK1.19819416
35CSK1.19793217
36HCK1.18940423
37ACVR1B1.16945935
38OXSR11.15690526
39FES1.11708780
40PRPF4B1.08149081
41GRK11.05615079
42GRK61.03613070
43LCK1.03597642
44TNK21.01668553
45ADRBK21.01393368
46PIK3CG1.00169583
47CCNB10.99138218
48MATK0.92748968
49SIK30.90719717
50IRAK10.81207172
51PIM10.79361980
52NUAK10.77393377
53CHUK0.75688763
54JAK20.72637757
55PDK10.72381395
56MARK30.70364315
57MAP4K20.70021074
58MAP3K100.69020870
59MAPK130.68158822
60FGR0.67885450
61VRK10.66298575
62STK100.66151622
63RPS6KA50.62067486
64MAPK110.61609844
65CDK40.56480228
66ABL10.52846047
67BMPR1B0.52422312
68MAP2K20.49489650
69MAPK70.49096917
70MAPK120.48278918
71MELK0.47855564
72TAF10.44998075
73ZAP700.44852538
74EIF2AK20.44498011
75PTK2B0.44497785
76STK110.43495483
77PINK10.39335676
78PRKCI0.38034131
79PRKCH0.37617069
80MAP3K50.37364221
81YES10.35838264
82ADRBK10.32424283
83PRKCD0.30614671
84FYN0.30017560
85BCKDK0.29436049
86PRKCZ0.29093699
87TRPM70.27825823
88MAPK40.27025796
89FGFR30.26168309
90INSRR0.25878391
91MAPKAPK30.24920168
92CDC42BPA0.24506573
93MAPKAPK50.23493972
94STK30.22904392
95PDPK10.22150005
96MAPKAPK20.21871224
97IRAK20.20835020
98INSR0.20635823
99IGF1R0.20412438
100MAP2K30.20285960

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046724.95495773
2Allograft rejection_Homo sapiens_hsa053304.81563138
3Asthma_Homo sapiens_hsa053104.81042547
4Autoimmune thyroid disease_Homo sapiens_hsa053204.49837088
5Graft-versus-host disease_Homo sapiens_hsa053324.40562193
6Primary immunodeficiency_Homo sapiens_hsa053403.92417303
7Type I diabetes mellitus_Homo sapiens_hsa049403.84933517
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.99568199
9Staphylococcus aureus infection_Homo sapiens_hsa051502.79220816
10Leishmaniasis_Homo sapiens_hsa051402.75598229
11B cell receptor signaling pathway_Homo sapiens_hsa046622.71493420
12Antigen processing and presentation_Homo sapiens_hsa046122.62489473
13Viral myocarditis_Homo sapiens_hsa054162.60835229
14Systemic lupus erythematosus_Homo sapiens_hsa053221.84699689
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.80451124
16Hematopoietic cell lineage_Homo sapiens_hsa046401.71890603
17Herpes simplex infection_Homo sapiens_hsa051681.69419399
18Tuberculosis_Homo sapiens_hsa051521.59680783
19Influenza A_Homo sapiens_hsa051641.57542372
20Rheumatoid arthritis_Homo sapiens_hsa053231.57434694
21Toxoplasmosis_Homo sapiens_hsa051451.44348324
22Measles_Homo sapiens_hsa051621.25756104
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24967158
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21702400
25Osteoclast differentiation_Homo sapiens_hsa043801.15785387
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07348019
27Epstein-Barr virus infection_Homo sapiens_hsa051691.06872839
28T cell receptor signaling pathway_Homo sapiens_hsa046600.98517608
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96938582
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86368129
31NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81615386
32Phagosome_Homo sapiens_hsa041450.79797376
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79561663
34Jak-STAT signaling pathway_Homo sapiens_hsa046300.76403024
35Homologous recombination_Homo sapiens_hsa034400.75853882
36Chemokine signaling pathway_Homo sapiens_hsa040620.69210680
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66691636
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66604915
39Hepatitis B_Homo sapiens_hsa051610.61093253
40Viral carcinogenesis_Homo sapiens_hsa052030.56771317
41HTLV-I infection_Homo sapiens_hsa051660.56407066
42TNF signaling pathway_Homo sapiens_hsa046680.54181260
43African trypanosomiasis_Homo sapiens_hsa051430.53455582
44Apoptosis_Homo sapiens_hsa042100.51589771
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50636179
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49876209
47Hepatitis C_Homo sapiens_hsa051600.44657112
48Non-homologous end-joining_Homo sapiens_hsa034500.43554059
49Linoleic acid metabolism_Homo sapiens_hsa005910.42126534
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42067606
51Legionellosis_Homo sapiens_hsa051340.41831342
52Platelet activation_Homo sapiens_hsa046110.41169859
53RNA degradation_Homo sapiens_hsa030180.40837584
54Alcoholism_Homo sapiens_hsa050340.40073600
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38252613
56Phototransduction_Homo sapiens_hsa047440.36087676
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35825395
58Ether lipid metabolism_Homo sapiens_hsa005650.31849601
59Fanconi anemia pathway_Homo sapiens_hsa034600.29157014
60Olfactory transduction_Homo sapiens_hsa047400.28896238
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27722378
62Ribosome_Homo sapiens_hsa030100.27696074
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27251751
64p53 signaling pathway_Homo sapiens_hsa041150.25970934
65Malaria_Homo sapiens_hsa051440.22670620
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20966413
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18743458
68One carbon pool by folate_Homo sapiens_hsa006700.17930925
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17843228
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16691576
71Pertussis_Homo sapiens_hsa051330.15801429
72Shigellosis_Homo sapiens_hsa051310.15795172
73Caffeine metabolism_Homo sapiens_hsa002320.14925271
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.13942309
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13362222
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.13050385
77Basal transcription factors_Homo sapiens_hsa030220.12781758
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.12392956
79Base excision repair_Homo sapiens_hsa034100.11299675
80Non-small cell lung cancer_Homo sapiens_hsa052230.08917431
81Acute myeloid leukemia_Homo sapiens_hsa052210.08903035
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.08859800
83MAPK signaling pathway_Homo sapiens_hsa040100.08227103
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.07827307
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.07583569
86Prolactin signaling pathway_Homo sapiens_hsa049170.07021658
87Nucleotide excision repair_Homo sapiens_hsa034200.05036323
88Arachidonic acid metabolism_Homo sapiens_hsa005900.05032576
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.04970422
90Regulation of autophagy_Homo sapiens_hsa041400.04929850
91Selenocompound metabolism_Homo sapiens_hsa004500.04702761
92Mismatch repair_Homo sapiens_hsa034300.04224253
93Dorso-ventral axis formation_Homo sapiens_hsa043200.03470771
94ABC transporters_Homo sapiens_hsa020100.03205115
95Serotonergic synapse_Homo sapiens_hsa047260.03181787
96Tryptophan metabolism_Homo sapiens_hsa003800.01979403
97Cholinergic synapse_Homo sapiens_hsa047250.01841028
98Butanoate metabolism_Homo sapiens_hsa006500.01234580
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00434668
100Morphine addiction_Homo sapiens_hsa05032-0.0144937

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