TLE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.70225694
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.70225694
3modulation by symbiont of host immune response (GO:0052553)5.70225694
4positive regulation by symbiont of host defense response (GO:0052509)5.70225694
5modulation by symbiont of host defense response (GO:0052031)5.70225694
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.70225694
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.05765467
8response to peptidoglycan (GO:0032494)4.92394207
9detection of other organism (GO:0098543)4.62541869
10neutrophil activation involved in immune response (GO:0002283)4.57233949
11macrophage activation involved in immune response (GO:0002281)4.50965284
12cellular extravasation (GO:0045123)4.50180454
13regulation of B cell receptor signaling pathway (GO:0050855)4.41150300
14detection of bacterium (GO:0016045)4.33368417
15negative regulation of interleukin-12 production (GO:0032695)4.14894396
16detection of molecule of bacterial origin (GO:0032490)4.12972539
17detection of external biotic stimulus (GO:0098581)3.97312298
18neutrophil activation (GO:0042119)3.97114902
19response to host immune response (GO:0052572)3.88354846
20response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.88354846
21positive thymic T cell selection (GO:0045059)3.87879566
22regulation of interferon-beta biosynthetic process (GO:0045357)3.87825750
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.84311205
24positive regulation of gamma-delta T cell activation (GO:0046645)3.72669122
25negative regulation of lymphocyte mediated immunity (GO:0002707)3.70159743
26detection of biotic stimulus (GO:0009595)3.69891112
27granulocyte activation (GO:0036230)3.63838770
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.62979131
29response to host (GO:0075136)3.62979131
30response to host defenses (GO:0052200)3.62979131
31regulation of gamma-delta T cell differentiation (GO:0045586)3.60116721
32pre-miRNA processing (GO:0031054)3.59981605
33respiratory burst (GO:0045730)3.59094020
34positive regulation of histone deacetylation (GO:0031065)3.56651451
35immunoglobulin mediated immune response (GO:0016064)3.52003575
36cellular response to interleukin-15 (GO:0071350)3.51555227
37cytoplasmic mRNA processing body assembly (GO:0033962)3.47224396
38macrophage activation (GO:0042116)3.41700913
39neutrophil mediated immunity (GO:0002446)3.37876549
40regulation of gamma-delta T cell activation (GO:0046643)3.35916709
41negative regulation of leukocyte mediated immunity (GO:0002704)3.34774844
42regulation of mast cell degranulation (GO:0043304)3.34280371
43thymic T cell selection (GO:0045061)3.33923411
44myeloid cell activation involved in immune response (GO:0002275)3.32174056
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.30171271
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30171271
47positive T cell selection (GO:0043368)3.26098507
48germinal center formation (GO:0002467)3.25401769
49negative regulation of T cell mediated immunity (GO:0002710)3.22926602
50negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.20630778
51microglial cell activation (GO:0001774)3.18904351
52negative T cell selection (GO:0043383)3.12209556
53B cell receptor signaling pathway (GO:0050853)3.11877715
54antigen processing and presentation of endogenous antigen (GO:0019883)3.09852232
55leukocyte migration involved in inflammatory response (GO:0002523)3.09650597
56negative thymic T cell selection (GO:0045060)3.07075184
57positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.07033038
58myeloid leukocyte mediated immunity (GO:0002444)3.06844210
59regulation of myeloid leukocyte mediated immunity (GO:0002886)3.06516656
60trophectodermal cell differentiation (GO:0001829)3.06186718
61dosage compensation (GO:0007549)3.05583437
62defense response to protozoan (GO:0042832)3.04676762
63heterochromatin organization (GO:0070828)3.03644870
64regulation of mast cell activation involved in immune response (GO:0033006)3.03317371
65regulation of leukocyte degranulation (GO:0043300)3.02595494
66production of molecular mediator involved in inflammatory response (GO:0002532)3.00003159
67T cell selection (GO:0045058)2.99534092
68negative regulation of cell killing (GO:0031342)2.97350307
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97350307
70regulation of interleukin-12 biosynthetic process (GO:0045075)2.96795525
71regulation of B cell differentiation (GO:0045577)2.95367381
72regulation of T-helper 2 cell differentiation (GO:0045628)2.90957644
73nuclear pore complex assembly (GO:0051292)2.90786325
74regulation of mast cell activation (GO:0033003)2.89364919
75antigen processing and presentation via MHC class Ib (GO:0002475)2.88889505
76RNA stabilization (GO:0043489)2.88285855
77mRNA stabilization (GO:0048255)2.88285855
78negative regulation of toll-like receptor signaling pathway (GO:0034122)2.87432715
79positive regulation of B cell differentiation (GO:0045579)2.87230559
80positive regulation of mast cell activation (GO:0033005)2.86878820
81negative regulation of histone methylation (GO:0031061)2.83569270
82leukocyte degranulation (GO:0043299)2.83557465
83B cell mediated immunity (GO:0019724)2.82763831
84regulation of RNA export from nucleus (GO:0046831)2.82366971
85negative regulation of interleukin-6 production (GO:0032715)2.80245482
86negative regulation of phagocytosis (GO:0050765)2.79982282
87intracellular estrogen receptor signaling pathway (GO:0030520)2.79069562
88negative regulation of T-helper cell differentiation (GO:0045623)2.78461244
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.78461244
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.77906821
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.75664700
92positive regulation of interferon-alpha production (GO:0032727)2.74873068
93positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73657664
94histone H3-K36 demethylation (GO:0070544)2.73649741
95negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.70480232
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69995533
97response to protozoan (GO:0001562)2.69834421
98dendritic cell chemotaxis (GO:0002407)2.67889305
99cellular response to type I interferon (GO:0071357)2.67496092
100type I interferon signaling pathway (GO:0060337)2.67496092
101negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.66839397
102response to type I interferon (GO:0034340)2.66625434
103negative regulation of innate immune response (GO:0045824)2.65826237
104regulation of chromatin binding (GO:0035561)2.65184443
105myeloid leukocyte activation (GO:0002274)2.64028304
106regulation of alpha-beta T cell proliferation (GO:0046640)2.62882136
107T cell migration (GO:0072678)2.62772612
108apoptotic process involved in morphogenesis (GO:0060561)2.62005162
109NLS-bearing protein import into nucleus (GO:0006607)2.61868830
110JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.61212645
111tolerance induction (GO:0002507)2.59526942
112nuclear pore organization (GO:0006999)2.56826084
113interferon-gamma production (GO:0032609)2.54712155
114regulation of translational fidelity (GO:0006450)2.54274879
115negative regulation of RNA splicing (GO:0033119)2.54051038
116response to laminar fluid shear stress (GO:0034616)2.53587326
117natural killer cell differentiation (GO:0001779)2.50809317
118positive regulation of protein deacetylation (GO:0090312)2.50745507
119positive regulation of gene expression, epigenetic (GO:0045815)2.49518906
120regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45423987
121glucocorticoid receptor signaling pathway (GO:0042921)2.44568418
122planar cell polarity pathway involved in neural tube closure (GO:0090179)2.43734265
123protein-DNA complex disassembly (GO:0032986)2.42040101
124nucleosome disassembly (GO:0006337)2.42040101
125histone lysine demethylation (GO:0070076)2.40435496
126establishment of apical/basal cell polarity (GO:0035089)2.39361569
127histone H2A monoubiquitination (GO:0035518)2.38779286
128growth hormone receptor signaling pathway (GO:0060396)2.38049290
129positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.37298936
130NIK/NF-kappaB signaling (GO:0038061)2.37039469
131endothelial tube morphogenesis (GO:0061154)2.35685088
132morphogenesis of an endothelium (GO:0003159)2.35685088
133pore complex assembly (GO:0046931)2.35646442
134negative regulation of erythrocyte differentiation (GO:0045647)2.35377280
135histone H3-K9 demethylation (GO:0033169)2.33738103
136peptidyl-lysine dimethylation (GO:0018027)2.33438741
137chromatin assembly (GO:0031497)2.31959021
138radial glial cell differentiation (GO:0060019)2.30525466
1393-UTR-mediated mRNA stabilization (GO:0070935)2.30455471
140leukocyte aggregation (GO:0070486)2.28355422
141histone H3-K4 methylation (GO:0051568)2.28013128
142corticosteroid receptor signaling pathway (GO:0031958)2.27992326
143negative regulation of mRNA processing (GO:0050686)2.27941133
144positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.27752254
145regulation of mRNA stability (GO:0043488)2.27675643
146histone demethylation (GO:0016577)2.27572363
147positive regulation by host of viral transcription (GO:0043923)2.27080531
148embryonic process involved in female pregnancy (GO:0060136)2.26922116
149regulation of NFAT protein import into nucleus (GO:0051532)2.26767782
150alternative mRNA splicing, via spliceosome (GO:0000380)2.25949462
151regulation of nucleobase-containing compound transport (GO:0032239)2.25096143
152histone H4-K12 acetylation (GO:0043983)2.24283738
153negative regulation of mRNA metabolic process (GO:1903312)2.24030134
154epithelial cell differentiation involved in prostate gland development (GO:0060742)2.23899937
155DNA unwinding involved in DNA replication (GO:0006268)2.23581476
156positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.23178991
157positive regulation of SMAD protein import into nucleus (GO:0060391)2.22863782
158germ cell migration (GO:0008354)2.22572694
159regulation of hippo signaling (GO:0035330)2.22498312
160polarized epithelial cell differentiation (GO:0030859)2.20693465
161response to interleukin-15 (GO:0070672)2.18743368
162regulation of histone H3-K9 methylation (GO:0051570)2.17562469
163regulation of RNA stability (GO:0043487)2.17382442
164negative regulation of granulocyte differentiation (GO:0030853)2.14526752
165hippo signaling (GO:0035329)2.13881256
166tyrosine phosphorylation of STAT protein (GO:0007260)2.12341364
167regulation of gene silencing by RNA (GO:0060966)2.12156277
168regulation of posttranscriptional gene silencing (GO:0060147)2.12156277
169regulation of gene silencing by miRNA (GO:0060964)2.12156277
170negative regulation of translation, ncRNA-mediated (GO:0040033)2.12085885
171regulation of translation, ncRNA-mediated (GO:0045974)2.12085885
172negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.12085885
173negative regulation of glial cell proliferation (GO:0060253)2.10345165
174negative regulation of gene expression, epigenetic (GO:0045814)2.10170418
175regulation of T cell tolerance induction (GO:0002664)2.09845124
176response to muramyl dipeptide (GO:0032495)2.09526973
177spliceosomal tri-snRNP complex assembly (GO:0000244)2.09458255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.79707846
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.39111112
3* MYC_22102868_ChIP-Seq_BL_Human4.02610545
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.81701899
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.33918753
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.26817883
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.08417443
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03999853
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02865138
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.01660707
11VDR_21846776_ChIP-Seq_THP-1_Human2.84979885
12* TCF7_22412390_ChIP-Seq_EML_Mouse2.72753303
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.53750484
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.53651007
15* KDM2B_26808549_Chip-Seq_DND41_Human2.50821732
16* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.43688967
17* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.31573658
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29335598
19* MAF_26560356_Chip-Seq_TH1_Human2.19905711
20* UTX_26944678_Chip-Seq_JUKART_Human2.05131686
21* ELK3_25401928_ChIP-Seq_HUVEC_Human2.00528730
22* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92140076
23* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88098883
24VDR_24763502_ChIP-Seq_THP-1_Human1.81021826
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.78815071
26* MYB_26560356_Chip-Seq_TH2_Human1.78610483
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75075314
28* KDM2B_26808549_Chip-Seq_JURKAT_Human1.74722540
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66835322
30* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66265959
31MYB_26560356_Chip-Seq_TH1_Human1.66108219
32RUNX_20019798_ChIP-Seq_JUKART_Human1.58952126
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56624488
34* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56135152
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56087226
36* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49116326
37* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48159661
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48002688
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46471497
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46037535
41VDR_24787735_ChIP-Seq_THP-1_Human1.45240253
42LXR_22292898_ChIP-Seq_THP-1_Human1.44222682
43* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44222443
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.43522875
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.42426253
46* NOTCH1_21737748_ChIP-Seq_TLL_Human1.42200705
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41847443
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41599724
49* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41442208
50* RACK7_27058665_Chip-Seq_MCF-7_Human1.41129935
51MAF_26560356_Chip-Seq_TH2_Human1.41095295
52* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40697164
53NCOR1_26117541_ChIP-Seq_K562_Human1.40600105
54CIITA_25753668_ChIP-Seq_RAJI_Human1.40361190
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38958446
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38958446
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38958446
58* KDM2B_26808549_Chip-Seq_K562_Human1.34976249
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34735034
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33470581
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33145745
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.32934624
63* SCL_19346495_ChIP-Seq_HPC-7_Human1.32871394
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31958929
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31434915
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29997759
67* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28501932
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28369360
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28219120
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28021126
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26137407
72* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26093190
73* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25644369
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25519558
75* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24523250
76* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23717774
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23570371
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23157134
79PU_27001747_Chip-Seq_BMDM_Mouse1.21605427
80PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20891454
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20527951
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19917459
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17871823
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17218794
85* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17179057
86SPI1_23127762_ChIP-Seq_K562_Human1.16506133
87* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15766884
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13912508
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13846890
90* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13302310
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13261028
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12793547
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12410805
94* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12199902
95* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12069100
96GATA1_19941826_ChIP-Seq_K562_Human1.11948895
97* ATF3_27146783_Chip-Seq_COLON_Human1.10221431
98* RUNX1_27514584_Chip-Seq_MCF-7_Human1.08424352
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07367219
100* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07254992
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07067407
102* CLOCK_20551151_ChIP-Seq_293T_Human1.06705339
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06504436
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06251109
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05893437
106* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05661064
107* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05647286
108* IRF8_27001747_Chip-Seq_BMDM_Mouse1.05588121
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05491569
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05222693
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.03952808
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02958598
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02890051
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.02887513
115UBF1/2_26484160_Chip-Seq_HMECs_Human1.01555261
116* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00483159
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98697872
118BCOR_27268052_Chip-Seq_Bcells_Human0.98576103
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.98391318
120TP53_22127205_ChIP-Seq_IMR90_Human0.97368741
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97234884
122ZNF263_19887448_ChIP-Seq_K562_Human0.97206507
123GATA6_25053715_ChIP-Seq_YYC3_Human0.97130502
124* CHD1_26751641_Chip-Seq_LNCaP_Human0.96977639
125RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96133772
126* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96068642
127GATA3_27048872_Chip-Seq_THYMUS_Human0.95331092
128KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94227840
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93546661
130GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93404956
131* CREB1_26743006_Chip-Seq_LNCaP_Human0.93371774
132MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93303946
133* E2F1_21310950_ChIP-Seq_MCF-7_Human0.92689865
134BCL6_27268052_Chip-Seq_Bcells_Human0.92055490
135TFEB_21752829_ChIP-Seq_HELA_Human0.91840172
136* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91818201
137SPI1_23547873_ChIP-Seq_NB4_Human0.91485847
138NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91187375
139CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89891260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.99685058
2MP0005076_abnormal_cell_differentiation3.16098998
3MP0002419_abnormal_innate_immunity2.71042261
4MP0010352_gastrointestinal_tract_polyps2.63224687
5MP0003705_abnormal_hypodermis_morpholog2.58220126
6MP0003300_gastrointestinal_ulcer2.52650216
7MP0009278_abnormal_bone_marrow2.34139054
8MP0003303_peritoneal_inflammation2.31432366
9MP0003763_abnormal_thymus_physiology2.10907614
10MP0008260_abnormal_autophagy2.09566714
11MP0004381_abnormal_hair_follicle2.09322733
12MP0002148_abnormal_hypersensitivity_rea1.95769722
13MP0000685_abnormal_immune_system1.95055333
14MP0009785_altered_susceptibility_to1.93342829
15MP0005310_abnormal_salivary_gland1.90776395
16MP0003828_pulmonary_edema1.84083974
17MP0003566_abnormal_cell_adhesion1.70169704
18MP0003172_abnormal_lysosome_physiology1.70085696
19MP0005451_abnormal_body_composition1.69243763
20MP0008961_abnormal_basal_metabolism1.68685477
21MP0001533_abnormal_skeleton_physiology1.64601661
22MP0003191_abnormal_cellular_cholesterol1.62587767
23MP0001800_abnormal_humoral_immune1.61906778
24MP0002277_abnormal_respiratory_mucosa1.58767815
25MP0010307_abnormal_tumor_latency1.58750474
26MP0004808_abnormal_hematopoietic_stem1.57909607
27MP0000703_abnormal_thymus_morphology1.57729702
28MP0005671_abnormal_response_to1.56822307
29MP0010234_abnormal_vibrissa_follicle1.55802095
30MP0010030_abnormal_orbit_morphology1.55717787
31MP0001790_abnormal_immune_system1.54649369
32MP0005387_immune_system_phenotype1.54649369
33MP0004947_skin_inflammation1.53862035
34MP0003436_decreased_susceptibility_to1.53457706
35MP0002396_abnormal_hematopoietic_system1.52293387
36MP0002398_abnormal_bone_marrow1.50942441
37MP0001845_abnormal_inflammatory_respons1.49401890
38MP0001849_ear_inflammation1.49070101
39MP0002166_altered_tumor_susceptibility1.49030601
40MP0002132_abnormal_respiratory_system1.45805626
41MP0000537_abnormal_urethra_morphology1.43965125
42MP0009333_abnormal_splenocyte_physiolog1.42083674
43MP0002405_respiratory_system_inflammati1.40567919
44MP0000733_abnormal_muscle_development1.40122509
45MP0001835_abnormal_antigen_presentation1.38542061
46MP0009053_abnormal_anal_canal1.36865165
47MP0002877_abnormal_melanocyte_morpholog1.35949354
48MP0002452_abnormal_antigen_presenting1.34456794
49MP0004197_abnormal_fetal_growth/weight/1.32029893
50MP0002254_reproductive_system_inflammat1.31665525
51MP0002420_abnormal_adaptive_immunity1.30658648
52MP0001819_abnormal_immune_cell1.29864981
53MP0000490_abnormal_crypts_of1.28998139
54MP0005000_abnormal_immune_tolerance1.28449659
55MP0003453_abnormal_keratinocyte_physiol1.27430016
56MP0000350_abnormal_cell_proliferation1.27358458
57MP0004185_abnormal_adipocyte_glucose1.26324805
58MP0008057_abnormal_DNA_replication1.25897551
59MP0005464_abnormal_platelet_physiology1.25454188
60MP0010155_abnormal_intestine_physiology1.23420351
61MP0002723_abnormal_immune_serum1.22562634
62MP0002722_abnormal_immune_system1.22289804
63MP0000716_abnormal_immune_system1.21934085
64MP0003077_abnormal_cell_cycle1.20594828
65MP0002086_abnormal_extraembryonic_tissu1.19902327
66MP0002084_abnormal_developmental_patter1.19403051
67MP0004264_abnormal_extraembryonic_tissu1.18056748
68MP0005023_abnormal_wound_healing1.17769824
69MP0003448_altered_tumor_morphology1.16717796
70MP0003183_abnormal_peptide_metabolism1.15230353
71MP0003984_embryonic_growth_retardation1.13887007
72MP0001730_embryonic_growth_arrest1.13796996
73MP0002088_abnormal_embryonic_growth/wei1.13734966
74MP0002006_tumorigenesis1.13316988
75MP0003111_abnormal_nucleus_morphology1.12981469
76MP0001873_stomach_inflammation1.12404372
77MP0005380_embryogenesis_phenotype1.12320793
78MP0001672_abnormal_embryogenesis/_devel1.12320793
79MP0001545_abnormal_hematopoietic_system1.10566071
80MP0005397_hematopoietic_system_phenotyp1.10566071
81MP0003866_abnormal_defecation1.09679082
82MP0002085_abnormal_embryonic_tissue1.09573934
83MP0008469_abnormal_protein_level1.08033270
84MP0000428_abnormal_craniofacial_morphol1.07520405
85MP0002653_abnormal_ependyma_morphology1.07513634
86MP0005075_abnormal_melanosome_morpholog1.06818105
87MP0002998_abnormal_bone_remodeling1.05931065
88MP0001851_eye_inflammation1.05900555
89MP0000689_abnormal_spleen_morphology1.05628426
90MP0002429_abnormal_blood_cell1.04052257
91MP0004957_abnormal_blastocyst_morpholog1.03980115
92MP0001853_heart_inflammation1.03767347
93MP0000858_altered_metastatic_potential1.03402042
94MP0003045_fibrosis1.02529610
95MP0003091_abnormal_cell_migration1.01524999
96MP0004510_myositis1.01397467
97MP0006082_CNS_inflammation1.01196303
98MP0010094_abnormal_chromosome_stability0.99193905
99MP0001216_abnormal_epidermal_layer0.98411773
100MP0006054_spinal_hemorrhage0.97412336
101MP0001915_intracranial_hemorrhage0.97338058
102MP0009764_decreased_sensitivity_to0.97322413
103MP0002796_impaired_skin_barrier0.97274325
104MP0002925_abnormal_cardiovascular_devel0.96736494
105MP0001697_abnormal_embryo_size0.96202050
106MP0000383_abnormal_hair_follicle0.94357437
107MP0008007_abnormal_cellular_replicative0.93944364
108MP0000569_abnormal_digit_pigmentation0.90482245
109MP0003890_abnormal_embryonic-extraembry0.89459435
110MP0000377_abnormal_hair_follicle0.89348170
111MP0002098_abnormal_vibrissa_morphology0.89178488
112MP0003075_altered_response_to0.88962092
113MP0002092_abnormal_eye_morphology0.88611699
114MP0003119_abnormal_digestive_system0.88549050
115MP0005025_abnormal_response_to0.88484209
116MP0010678_abnormal_skin_adnexa0.87802853
117MP0002009_preneoplasia0.86478163
118MP0000465_gastrointestinal_hemorrhage0.86161859
119MP0005058_abnormal_lysosome_morphology0.85907549
120MP0003935_abnormal_craniofacial_develop0.85852457
121MP0004883_abnormal_blood_vessel0.85716148
122MP0002019_abnormal_tumor_incidence0.85569559
123MP0003115_abnormal_respiratory_system0.83468968
124MP0000477_abnormal_intestine_morphology0.81403978
125MP0002080_prenatal_lethality0.81250343
126MP0005623_abnormal_meninges_morphology0.81142073
127MP0003221_abnormal_cardiomyocyte_apopto0.77617393
128MP0005390_skeleton_phenotype0.73053802
129MP0000516_abnormal_urinary_system0.71835485
130MP0005367_renal/urinary_system_phenotyp0.71835485
131MP0004858_abnormal_nervous_system0.71357716
132MP0009931_abnormal_skin_appearance0.66135006
133MP0005166_decreased_susceptibility_to0.64484965
134MP0008004_abnormal_stomach_pH0.63967439
135MP0001663_abnormal_digestive_system0.62763117
136MP0000313_abnormal_cell_death0.62191918
137MP0000470_abnormal_stomach_morphology0.61294579
138MP0009115_abnormal_fat_cell0.58577232
139MP0003656_abnormal_erythrocyte_physiolo0.58560898
140MP0008995_early_reproductive_senescence0.56368544
141MP0003795_abnormal_bone_structure0.55967761
142MP0005377_hearing/vestibular/ear_phenot0.54792480
143MP0003878_abnormal_ear_physiology0.54792480
144MP0000371_diluted_coat_color0.54090792
145MP0002933_joint_inflammation0.53938177
146MP0009763_increased_sensitivity_to0.53183550

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.24199626
2Recurrent abscess formation (HP:0002722)5.23626558
3Myositis (HP:0100614)4.87037565
4Orchitis (HP:0100796)4.79655190
5Optic neuritis (HP:0100653)4.63770812
6Retrobulbar optic neuritis (HP:0100654)4.63770812
7Abnormality of macrophages (HP:0004311)4.57886110
8Stomatitis (HP:0010280)4.55072108
9Elevated erythrocyte sedimentation rate (HP:0003565)4.09788869
10Mediastinal lymphadenopathy (HP:0100721)4.06032567
11Abnormality of the fingertips (HP:0001211)3.63464894
12Meningitis (HP:0001287)3.61403994
13Recurrent gram-negative bacterial infections (HP:0005420)3.58185390
14Gastrointestinal infarctions (HP:0005244)3.48922488
15Obstructive lung disease (HP:0006536)3.46859663
16Chronic obstructive pulmonary disease (HP:0006510)3.46859663
17Keratoconjunctivitis sicca (HP:0001097)3.40982370
18Recurrent skin infections (HP:0001581)3.39493967
19Chronic mucocutaneous candidiasis (HP:0002728)3.21543914
20Recurrent cutaneous fungal infections (HP:0011370)3.21543914
21Encephalitis (HP:0002383)3.20796511
22Vasculitis (HP:0002633)3.19866199
23Spontaneous hematomas (HP:0007420)3.14474545
24Keratoconjunctivitis (HP:0001096)3.12203544
25Gingivitis (HP:0000230)3.07899773
26Hyperacusis (HP:0010780)3.07189110
27Urticaria (HP:0001025)3.02984102
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.87001332
29Short 4th metacarpal (HP:0010044)2.87001332
30Chest pain (HP:0100749)2.78963094
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.78149351
32Cerebral aneurysm (HP:0004944)2.77948207
33Arterial thrombosis (HP:0004420)2.74166435
34Increased density of long bones (HP:0006392)2.73660781
35Increased cerebral lipofuscin (HP:0011813)2.72217780
36Hypochromic anemia (HP:0001931)2.70715615
37Hemoptysis (HP:0002105)2.64718605
38Leukocytosis (HP:0001974)2.61439997
39Pulmonary infiltrates (HP:0002113)2.46434523
40Lymphopenia (HP:0001888)2.45861321
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.45817322
42Panhypogammaglobulinemia (HP:0003139)2.41032249
43Renal duplication (HP:0000075)2.40870248
44Nasal polyposis (HP:0100582)2.40276486
45Prolonged bleeding time (HP:0003010)2.39712038
46Shallow orbits (HP:0000586)2.39419968
47Anorexia (HP:0002039)2.38497609
48Abnormality of T cell physiology (HP:0011840)2.37714466
49T lymphocytopenia (HP:0005403)2.34369614
50Persistence of primary teeth (HP:0006335)2.33648407
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.33447448
52Neonatal hypoglycemia (HP:0001998)2.30988160
53Abnormality of the columella (HP:0009929)2.26605248
54Sepsis (HP:0100806)2.26074852
55Episodic fever (HP:0001954)2.23879823
56Hypochromic microcytic anemia (HP:0004840)2.22557970
57Increased IgE level (HP:0003212)2.21601976
58Granulocytopenia (HP:0001913)2.19541145
59Abnormality of T cell number (HP:0011839)2.18801258
60Osteomyelitis (HP:0002754)2.18510081
61Slow saccadic eye movements (HP:0000514)2.16117831
62Recurrent fungal infections (HP:0002841)2.14010068
63Recurrent viral infections (HP:0004429)2.13811743
64Ulnar bowing (HP:0003031)2.13378045
65Long eyelashes (HP:0000527)2.13089581
66Segmental peripheral demyelination/remyelination (HP:0003481)2.12501381
67Abnormality of the 4th metacarpal (HP:0010012)2.11562386
68Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11242128
69Pulmonary embolism (HP:0002204)2.10355728
70Eczematoid dermatitis (HP:0000976)2.08550701
71Trigonocephaly (HP:0000243)2.05469250
72Abnormality of the nasal mucosa (HP:0000433)2.03843244
73Gangrene (HP:0100758)2.00866488
74Heterotopia (HP:0002282)2.00013172
75Prostate neoplasm (HP:0100787)1.98954916
76Amyloidosis (HP:0011034)1.98918330
77Viral hepatitis (HP:0006562)1.98818065
78Abnormality of the pleura (HP:0002103)1.98705577
79Gastrointestinal stroma tumor (HP:0100723)1.98182690
80Autoimmune hemolytic anemia (HP:0001890)1.96904162
81Petechiae (HP:0000967)1.96090022
82Increased IgM level (HP:0003496)1.94849118
83Elfin facies (HP:0004428)1.93523482
84Skin tags (HP:0010609)1.93522332
85Rib fusion (HP:0000902)1.92884442
86Epistaxis (HP:0000421)1.92791066
87Urethral obstruction (HP:0000796)1.92084174
88Broad thumb (HP:0011304)1.90989817
89Cellulitis (HP:0100658)1.89403079
90Increased nuchal translucency (HP:0010880)1.89017854
91Gastrointestinal inflammation (HP:0004386)1.86706695
92Loss of speech (HP:0002371)1.86544983
93Keratitis (HP:0000491)1.86219632
94Chronic otitis media (HP:0000389)1.86038529
95Pseudobulbar signs (HP:0002200)1.85965280
96Ependymoma (HP:0002888)1.85694081
97Increased serum ferritin (HP:0003281)1.85461460
98Deviation of the thumb (HP:0009603)1.84247676
99Abnormal delayed hypersensitivity skin test (HP:0002963)1.84120388
100Hematochezia (HP:0002573)1.82814081
101Abnormality of the distal phalanx of the thumb (HP:0009617)1.81581614
102Restrictive lung disease (HP:0002091)1.80370565
103Macroorchidism (HP:0000053)1.80233020
104Basal cell carcinoma (HP:0002671)1.80082533
105Broad face (HP:0000283)1.79207090
106Bicuspid aortic valve (HP:0001647)1.78959071
107Aortic aneurysm (HP:0004942)1.78900677
108Fatigue (HP:0012378)1.78386055
109Inflammation of the large intestine (HP:0002037)1.78079335
110Malignant gastrointestinal tract tumors (HP:0006749)1.77905070
111Gastrointestinal carcinoma (HP:0002672)1.77905070
112Short phalanx of the thumb (HP:0009660)1.77821255
113Recurrent bronchitis (HP:0002837)1.77298393
114Autoimmune thrombocytopenia (HP:0001973)1.77061495
115Selective tooth agenesis (HP:0001592)1.76972351
116Supernumerary ribs (HP:0005815)1.76778594
117Mitral valve prolapse (HP:0001634)1.76291270
118Skin ulcer (HP:0200042)1.74903046
119Abnormality of the endocardium (HP:0004306)1.74882717
120Amaurosis fugax (HP:0100576)1.74765862
121Volvulus (HP:0002580)1.73851456
122Subacute progressive viral hepatitis (HP:0006572)1.73550524
123Renovascular hypertension (HP:0100817)1.73534137
124Colitis (HP:0002583)1.73369669
125Ureteral stenosis (HP:0000071)1.72985597
126Overriding aorta (HP:0002623)1.72476877
127Proximal placement of thumb (HP:0009623)1.71623170
128Eosinophilia (HP:0001880)1.71531130
129Obstructive sleep apnea (HP:0002870)1.71353547
130IgM deficiency (HP:0002850)1.69691174
131Malnutrition (HP:0004395)1.69138555
132Abnormality of T cells (HP:0002843)1.69067489
133Verrucae (HP:0200043)1.69022162
134Papilloma (HP:0012740)1.69022162
135Agammaglobulinemia (HP:0004432)1.68534505
136Broad palm (HP:0001169)1.68359485
137Aplasia/Hypoplasia of the thymus (HP:0010515)1.68035921
138Gingival bleeding (HP:0000225)1.67912323
139Premature loss of primary teeth (HP:0006323)1.67716024
140Narrow palate (HP:0000189)1.67002444
141Abnormality of eosinophils (HP:0001879)1.66425383
142Ureteral obstruction (HP:0006000)1.65768266
143Long palpebral fissure (HP:0000637)1.64811518
144Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64608208
145Milia (HP:0001056)1.63754823
146Lip pit (HP:0100267)1.63712896
147Vertigo (HP:0002321)1.62772252
148Abnormality of the gastric mucosa (HP:0004295)1.62369880
149Dislocated radial head (HP:0003083)1.62234824
150Anal stenosis (HP:0002025)1.59806567
151Vertebral fusion (HP:0002948)1.59763824
152Preauricular skin tag (HP:0000384)1.59669974
153Pustule (HP:0200039)1.59552195
154Short 5th finger (HP:0009237)1.59127919
155Combined immunodeficiency (HP:0005387)1.58764486
156Syringomyelia (HP:0003396)1.58514468
157Spinal cord lesions (HP:0100561)1.58514468
158Dilatation of the ascending aorta (HP:0005111)1.58001033
159Hand muscle atrophy (HP:0009130)1.57677740
160Abnormality of the radial head (HP:0003995)1.57584681
161Abnormality of the intervertebral disk (HP:0005108)1.56789630
162Abnormal number of incisors (HP:0011064)1.56680387
163Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.56630714
164Short 1st metacarpal (HP:0010034)1.56630714
165Cutis marmorata (HP:0000965)1.56200621
166Deviation of the hallux (HP:0010051)1.55779959
167Hypoplastic labia majora (HP:0000059)1.54736642
168Prominent nose (HP:0000448)1.54282467
169Hallux valgus (HP:0001822)1.53829293
170Rectal prolapse (HP:0002035)1.53767269
171Disproportionate tall stature (HP:0001519)1.52950039
172Abnormality of the peritoneum (HP:0002585)1.52677851
173High pitched voice (HP:0001620)1.52172138
174Abnormality of the astrocytes (HP:0100707)1.51951629
175Astrocytoma (HP:0009592)1.51951629
176Aneurysm (HP:0002617)1.51853814
177Broad phalanges of the hand (HP:0009768)1.51514648
178Genu recurvatum (HP:0002816)1.50970626
179Sparse lateral eyebrow (HP:0005338)1.50168730
180Bowel diverticulosis (HP:0005222)1.50111252
181Spina bifida occulta (HP:0003298)1.48749301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.30167746
2MAP3K104.19119699
3RIPK43.64084397
4EEF2K3.40601195
5TRIB33.13567484
6MAP4K13.12345219
7IRAK42.96799673
8PRPF4B2.77010605
9MAP2K32.55533177
10TNK22.49010445
11SMG12.39220536
12STK102.23036146
13FES2.10966980
14ERN12.08880828
15SIK32.00863251
16ICK1.96439802
17MAP3K31.85811726
18PKN21.85482387
19FGFR41.77279991
20IRAK21.71930648
21PTK61.70868005
22BRD41.60938067
23FGFR31.58022664
24EPHB11.56238638
25GRK61.54101031
26IRAK11.49140671
27PDGFRA1.48250799
28JAK31.46918852
29TYRO31.41516573
30MTOR1.35645270
31ALK1.35627276
32RIPK11.34775064
33SIK11.33352336
34PASK1.30610031
35CSK1.29149163
36LRRK21.27623957
37ITK1.27375799
38CDK61.26464129
39ZAP701.25515264
40EPHA31.24230836
41MAP3K131.23798183
42CHUK1.22326850
43RPS6KB21.22311701
44NEK21.21244734
45TYK21.19019294
46BMX1.18325244
47MAP3K11.18269382
48LATS11.16797355
49FGR1.16370390
50CAMK1D1.12695702
51CDK41.12019668
52KSR21.11768001
53TXK1.11065561
54IRAK31.10343907
55PIM11.08849086
56SIK21.04291037
57PAK41.02925664
58LYN1.02281368
59JAK11.01529165
60YES10.98084777
61CAMK1G0.97693785
62BTK0.97446093
63STK30.95912700
64PDGFRB0.95397531
65HIPK20.94238478
66TGFBR20.93190998
67HCK0.90971175
68RPS6KA40.88990752
69BLK0.88235133
70DMPK0.88050202
71TTN0.84584169
72CDC70.84257478
73TAOK30.82220184
74CSF1R0.81462027
75TBK10.80809894
76EPHB20.80650641
77CDK70.80611687
78MAP3K80.80372051
79PAK20.79511524
80FGFR20.79109607
81CDK90.78847949
82MAP3K140.74792880
83DYRK1B0.74773724
84SGK30.73303413
85MAPK70.72867843
86RAF10.72564249
87LCK0.70975194
88TAOK20.70950127
89PDK10.70594939
90CLK10.69198496
91TESK20.69136430
92TAOK10.68920311
93NLK0.67360992
94FGFR10.66638176
95RPS6KL10.66548782
96RPS6KC10.66548782
97MARK30.65072271
98IKBKB0.64372974
99PDPK10.64214686
100DDR20.63697362
101TSSK60.62902732
102PTK20.61404002
103MAPK150.60984134
104PRKD20.60411311
105MAP3K70.60260461
106MAPK120.58533032
107EPHA20.56850262
108JAK20.56780216
109CHEK10.56601453
110IKBKE0.54879626
111SGK20.54446823
112STK110.52842317
113KSR10.50533638
114KIT0.49554099
115TEC0.48704204
116MAP3K20.48621697
117TGFBR10.47784496
118STK40.46708280
119SCYL20.46451330
120PDK20.46239071
121MAP2K20.45704545
122GSK3A0.45235028
123MAPKAPK20.44934761
124MARK20.44789305
125SYK0.44540185
126* RPS6KA10.44144454
127ATR0.43534880
128PRKD30.43215641
129MAP3K110.43140773
130* CDK20.42338056
131RPS6KA20.42090278
132CDC42BPA0.41704567
133MELK0.41511115
134AKT30.41114354
135MST40.39597411
136CAMK40.39572420
137EGFR0.39005504
138MATK0.38562489
139MAPK10.37170033
140RPS6KA60.36685200
141PRKCH0.36495001
142MAP3K60.35164659
143RET0.34447147
144BMPR20.34250568

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053401.94926176
2Notch signaling pathway_Homo sapiens_hsa043301.92460687
3Staphylococcus aureus infection_Homo sapiens_hsa051501.91781363
4Chronic myeloid leukemia_Homo sapiens_hsa052201.86752085
5B cell receptor signaling pathway_Homo sapiens_hsa046621.72807753
6T cell receptor signaling pathway_Homo sapiens_hsa046601.72506100
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.67761701
8Acute myeloid leukemia_Homo sapiens_hsa052211.65941651
9Antigen processing and presentation_Homo sapiens_hsa046121.56680403
10Osteoclast differentiation_Homo sapiens_hsa043801.54517140
11Leishmaniasis_Homo sapiens_hsa051401.52757531
12MicroRNAs in cancer_Homo sapiens_hsa052061.51596559
13Measles_Homo sapiens_hsa051621.50713639
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47160038
15Toxoplasmosis_Homo sapiens_hsa051451.44241722
16Viral myocarditis_Homo sapiens_hsa054161.42699169
17Small cell lung cancer_Homo sapiens_hsa052221.42544796
18Adherens junction_Homo sapiens_hsa045201.42095913
19Basal cell carcinoma_Homo sapiens_hsa052171.41167898
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33743357
21Colorectal cancer_Homo sapiens_hsa052101.32789410
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32216388
23HTLV-I infection_Homo sapiens_hsa051661.31924831
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29889865
25mTOR signaling pathway_Homo sapiens_hsa041501.28563175
26Herpes simplex infection_Homo sapiens_hsa051681.27400526
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27360488
28Pancreatic cancer_Homo sapiens_hsa052121.27171702
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26666145
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.26522927
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.25217274
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25159262
33Proteoglycans in cancer_Homo sapiens_hsa052051.23106683
34Lysine degradation_Homo sapiens_hsa003101.21565119
35Viral carcinogenesis_Homo sapiens_hsa052031.21205146
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19385387
37mRNA surveillance pathway_Homo sapiens_hsa030151.18463346
38Hepatitis B_Homo sapiens_hsa051611.18312304
39Apoptosis_Homo sapiens_hsa042101.18283228
40Other glycan degradation_Homo sapiens_hsa005111.16383652
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13262972
42Hippo signaling pathway_Homo sapiens_hsa043901.12527263
43Endometrial cancer_Homo sapiens_hsa052131.12392197
44Non-small cell lung cancer_Homo sapiens_hsa052231.12089614
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.11174158
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.11083583
47TNF signaling pathway_Homo sapiens_hsa046681.09977418
48Spliceosome_Homo sapiens_hsa030401.09274585
49Shigellosis_Homo sapiens_hsa051311.05355777
50VEGF signaling pathway_Homo sapiens_hsa043701.05031483
51Type I diabetes mellitus_Homo sapiens_hsa049401.02247870
52Prolactin signaling pathway_Homo sapiens_hsa049171.01695922
53Influenza A_Homo sapiens_hsa051641.01482290
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00540438
55Allograft rejection_Homo sapiens_hsa053301.00405132
56Prostate cancer_Homo sapiens_hsa052151.00142556
57Hematopoietic cell lineage_Homo sapiens_hsa046400.99079013
58Dorso-ventral axis formation_Homo sapiens_hsa043200.97484031
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96491741
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96153357
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95944127
62Renal cell carcinoma_Homo sapiens_hsa052110.94200618
63Chemokine signaling pathway_Homo sapiens_hsa040620.93899876
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93543954
65Legionellosis_Homo sapiens_hsa051340.91308369
66Pathways in cancer_Homo sapiens_hsa052000.91099947
67Graft-versus-host disease_Homo sapiens_hsa053320.90950863
68Hedgehog signaling pathway_Homo sapiens_hsa043400.90065863
69Epstein-Barr virus infection_Homo sapiens_hsa051690.89816848
70Focal adhesion_Homo sapiens_hsa045100.88636248
71Choline metabolism in cancer_Homo sapiens_hsa052310.87988008
72p53 signaling pathway_Homo sapiens_hsa041150.87874681
73Cell cycle_Homo sapiens_hsa041100.85697347
74TGF-beta signaling pathway_Homo sapiens_hsa043500.84790874
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83851356
76RNA transport_Homo sapiens_hsa030130.82789062
77Insulin resistance_Homo sapiens_hsa049310.82648458
78Thyroid cancer_Homo sapiens_hsa052160.82048190
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81907568
80Bladder cancer_Homo sapiens_hsa052190.81170410
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80249320
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.80107117
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78953964
84Inositol phosphate metabolism_Homo sapiens_hsa005620.78952534
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78951742
86Base excision repair_Homo sapiens_hsa034100.77169930
87FoxO signaling pathway_Homo sapiens_hsa040680.77043574
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.76242278
89Platelet activation_Homo sapiens_hsa046110.75249385
90Tuberculosis_Homo sapiens_hsa051520.74694933
91Wnt signaling pathway_Homo sapiens_hsa043100.74434460
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74433166
93Pertussis_Homo sapiens_hsa051330.74186539
94Phagosome_Homo sapiens_hsa041450.72436597
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72075203
96Glioma_Homo sapiens_hsa052140.70699505
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70172260
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.69690405
99African trypanosomiasis_Homo sapiens_hsa051430.69289389
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68529761
101Salmonella infection_Homo sapiens_hsa051320.68506284
102Hepatitis C_Homo sapiens_hsa051600.68391418
103HIF-1 signaling pathway_Homo sapiens_hsa040660.66075596
104MAPK signaling pathway_Homo sapiens_hsa040100.65933257
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65786031
106Amoebiasis_Homo sapiens_hsa051460.64971594
107Type II diabetes mellitus_Homo sapiens_hsa049300.64788150
108GnRH signaling pathway_Homo sapiens_hsa049120.63806459
109Rap1 signaling pathway_Homo sapiens_hsa040150.61944971
110Lysosome_Homo sapiens_hsa041420.61629392
111Estrogen signaling pathway_Homo sapiens_hsa049150.61405075
112Autoimmune thyroid disease_Homo sapiens_hsa053200.61292536
113Rheumatoid arthritis_Homo sapiens_hsa053230.60092720
114ErbB signaling pathway_Homo sapiens_hsa040120.59293803
115Insulin signaling pathway_Homo sapiens_hsa049100.58930241
116Endocytosis_Homo sapiens_hsa041440.58735639
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58160952
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57713165
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57183255
120Asthma_Homo sapiens_hsa053100.55781929
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.55014585
122Malaria_Homo sapiens_hsa051440.54983701
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43211386
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41842079

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