TIPIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.62618049
2telomere maintenance via semi-conservative replication (GO:0032201)5.42855266
3DNA replication initiation (GO:0006270)5.40782032
4DNA strand elongation (GO:0022616)5.37379279
5telomere maintenance via recombination (GO:0000722)4.93288685
6CENP-A containing nucleosome assembly (GO:0034080)4.78101144
7chromatin remodeling at centromere (GO:0031055)4.71706223
8mitotic recombination (GO:0006312)4.68328253
9DNA unwinding involved in DNA replication (GO:0006268)4.64090726
10* DNA replication checkpoint (GO:0000076)4.60972370
11mitotic metaphase plate congression (GO:0007080)4.51215160
12nucleobase biosynthetic process (GO:0046112)4.50201297
13DNA deamination (GO:0045006)4.49267074
14ribosomal small subunit assembly (GO:0000028)4.45733737
15purine nucleobase biosynthetic process (GO:0009113)4.40863782
16protein localization to kinetochore (GO:0034501)4.39568891
17telomere maintenance via telomere lengthening (GO:0010833)4.29791046
18DNA replication-independent nucleosome organization (GO:0034724)4.28056890
19DNA replication-independent nucleosome assembly (GO:0006336)4.28056890
20nucleotide-excision repair, DNA gap filling (GO:0006297)4.16957270
21regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.14520712
22kinetochore organization (GO:0051383)4.12439373
23maturation of SSU-rRNA (GO:0030490)4.08142240
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.03206529
25DNA replication-dependent nucleosome organization (GO:0034723)4.02916193
26DNA replication-dependent nucleosome assembly (GO:0006335)4.02916193
27metaphase plate congression (GO:0051310)4.00137061
28formation of translation preinitiation complex (GO:0001731)3.96166505
29histone exchange (GO:0043486)3.94281604
30regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.89541824
31regulation of mitotic spindle checkpoint (GO:1903504)3.89541824
32attachment of spindle microtubules to kinetochore (GO:0008608)3.86603482
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.82774498
34protein localization to chromosome, centromeric region (GO:0071459)3.81289702
35kinetochore assembly (GO:0051382)3.77934885
36ribosome biogenesis (GO:0042254)3.77427152
37cullin deneddylation (GO:0010388)3.73825291
38IMP biosynthetic process (GO:0006188)3.70738208
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.68671794
40ATP synthesis coupled proton transport (GO:0015986)3.66659379
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.66659379
42mitotic nuclear envelope disassembly (GO:0007077)3.65868094
43ribosome assembly (GO:0042255)3.63586264
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.59985658
45ribonucleoprotein complex biogenesis (GO:0022613)3.59405041
46meiotic chromosome segregation (GO:0045132)3.56557287
47establishment of chromosome localization (GO:0051303)3.56171780
48chaperone-mediated protein transport (GO:0072321)3.55513550
49transcription-coupled nucleotide-excision repair (GO:0006283)3.55195890
50mitotic chromosome condensation (GO:0007076)3.54238346
51spliceosomal snRNP assembly (GO:0000387)3.52085072
52DNA double-strand break processing (GO:0000729)3.51167753
53mitochondrial RNA metabolic process (GO:0000959)3.50028016
54viral transcription (GO:0019083)3.48553792
55regulation of double-strand break repair via homologous recombination (GO:0010569)3.48517241
56translational termination (GO:0006415)3.48203788
57protein deneddylation (GO:0000338)3.47605343
58ribosomal large subunit biogenesis (GO:0042273)3.41117769
59DNA catabolic process, exonucleolytic (GO:0000738)3.40527494
60ribosomal small subunit biogenesis (GO:0042274)3.39639840
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36870111
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36870111
63telomere organization (GO:0032200)3.36193412
64telomere maintenance (GO:0000723)3.36114108
65nuclear envelope disassembly (GO:0051081)3.35598907
66membrane disassembly (GO:0030397)3.35598907
67rRNA processing (GO:0006364)3.35391080
68proteasome assembly (GO:0043248)3.35173268
69histone mRNA metabolic process (GO:0008334)3.31643290
70establishment of integrated proviral latency (GO:0075713)3.31063026
71G1/S transition of mitotic cell cycle (GO:0000082)3.30791052
72cell cycle G1/S phase transition (GO:0044843)3.30791052
73nuclear pore organization (GO:0006999)3.28909308
74rRNA methylation (GO:0031167)3.28646295
75IMP metabolic process (GO:0046040)3.28394383
76negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27789406
77negative regulation of ligase activity (GO:0051352)3.27789406
78replication fork processing (GO:0031297)3.26417479
79folic acid-containing compound biosynthetic process (GO:0009396)3.25864644
80mitotic sister chromatid segregation (GO:0000070)3.25343552
81pseudouridine synthesis (GO:0001522)3.25219188
82rRNA metabolic process (GO:0016072)3.24114196
83translational elongation (GO:0006414)3.19836809
84translational initiation (GO:0006413)3.19702845
85rRNA modification (GO:0000154)3.18706651
86deoxyribonucleotide biosynthetic process (GO:0009263)3.18480232
87mismatch repair (GO:0006298)3.18157715
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.17879701
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17879701
90regulation of mitochondrial translation (GO:0070129)3.17053421
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16181651
92DNA ligation (GO:0006266)3.16148870
93chromatin assembly or disassembly (GO:0006333)3.15302614
94mitochondrial respiratory chain complex assembly (GO:0033108)3.14291950
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.13693370
96mitochondrial respiratory chain complex I assembly (GO:0032981)3.13693370
97NADH dehydrogenase complex assembly (GO:0010257)3.13693370
98* negative regulation of DNA-dependent DNA replication (GO:2000104)3.12265241
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.11709449
100termination of RNA polymerase III transcription (GO:0006386)3.11313175
101transcription elongation from RNA polymerase III promoter (GO:0006385)3.11313175
102transcription from mitochondrial promoter (GO:0006390)3.10964330
103regulation of spindle organization (GO:0090224)3.10905565
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10759113
105regulation of centriole replication (GO:0046599)3.09716608
106SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08912245
107spliceosomal complex assembly (GO:0000245)3.08846773
108protein K6-linked ubiquitination (GO:0085020)3.07227283
109respiratory chain complex IV assembly (GO:0008535)3.06681185
110protein complex biogenesis (GO:0070271)3.05772533
111sister chromatid segregation (GO:0000819)3.04596136
112maturation of 5.8S rRNA (GO:0000460)3.02344012
113spindle checkpoint (GO:0031577)3.01280835
114cotranslational protein targeting to membrane (GO:0006613)3.01225178
115positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00515850
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.00180718
117nuclear pore complex assembly (GO:0051292)2.99807015
118ATP-dependent chromatin remodeling (GO:0043044)2.99528282
119protein targeting to ER (GO:0045047)2.98759329
120DNA duplex unwinding (GO:0032508)2.98683325
121DNA geometric change (GO:0032392)2.98018922
122DNA replication (GO:0006260)2.97834158
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96589557
1247-methylguanosine mRNA capping (GO:0006370)2.96360930
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.95510431
126negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95510431
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95510431
128negative regulation of sister chromatid segregation (GO:0033046)2.95510431
1297-methylguanosine RNA capping (GO:0009452)2.95167272
130RNA capping (GO:0036260)2.95167272
131positive regulation of chromosome segregation (GO:0051984)2.95074405
132negative regulation of chromosome segregation (GO:0051985)2.94898835
133mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93325957
134regulation of helicase activity (GO:0051095)2.92949794
135postreplication repair (GO:0006301)2.91677348
136somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.90960681
137isotype switching (GO:0045190)2.90960681
138somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.90960681
139recombinational repair (GO:0000725)2.90765464
140RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90647157
141synapsis (GO:0007129)2.90383893
142double-strand break repair via homologous recombination (GO:0000724)2.90159389
143DNA damage response, detection of DNA damage (GO:0042769)2.90016715
144positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89982269
145signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89535514
146signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89535514
147signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89535514
148non-recombinational repair (GO:0000726)2.89378039

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.85088879
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.32707082
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.03007718
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.79426045
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61061672
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58412397
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22689885
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.16903345
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.06720273
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95107260
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93056676
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86663054
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86046060
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.81368273
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74200945
16* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51091788
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37179017
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37049890
19* VDR_23849224_ChIP-Seq_CD4+_Human2.33296469
20* XRN2_22483619_ChIP-Seq_HELA_Human2.26929854
21* AR_21909140_ChIP-Seq_LNCAP_Human2.23691856
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17935805
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16289326
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12799849
25* E2F1_21310950_ChIP-Seq_MCF-7_Human2.12532573
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08707941
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06489378
28FOXP3_21729870_ChIP-Seq_TREG_Human2.04970324
29ZNF274_21170338_ChIP-Seq_K562_Hela2.03685838
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03485506
31DCP1A_22483619_ChIP-Seq_HELA_Human2.03279269
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00258483
33* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97949404
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91011768
35GABP_19822575_ChIP-Seq_HepG2_Human1.89805186
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87011168
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85044942
38TTF2_22483619_ChIP-Seq_HELA_Human1.83562941
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82286214
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81759191
41ELK1_19687146_ChIP-ChIP_HELA_Human1.77925648
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76986435
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76603595
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72554908
45* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71377737
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70402956
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62224564
48EWS_26573619_Chip-Seq_HEK293_Human1.61858274
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59973455
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.58344020
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.56771521
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55628173
53VDR_22108803_ChIP-Seq_LS180_Human1.54954098
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.53639212
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51119697
56CIITA_25753668_ChIP-Seq_RAJI_Human1.48475312
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45340034
58FUS_26573619_Chip-Seq_HEK293_Human1.41804709
59KDM5A_27292631_Chip-Seq_BREAST_Human1.34010993
60* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33510701
61* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31072102
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27413805
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27259656
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27114195
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25429718
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22694357
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20612323
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19004973
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16553101
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15938057
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15107681
72MYC_22102868_ChIP-Seq_BL_Human1.14100189
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11236766
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11002251
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.08764641
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.08381166
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.08008548
78MYC_18940864_ChIP-ChIP_HL60_Human1.06316554
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06026842
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04490274
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02408188
82TFEB_21752829_ChIP-Seq_HELA_Human1.02152407
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.01803616
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00358454
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99531626
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97660236
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97507348
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96350079
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96208021
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95002779
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94189411
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92991887
93SPI1_23547873_ChIP-Seq_NB4_Human0.90578814
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89241921
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89150109
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.88906699
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86953479
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85858936
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85442545
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.84930989
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83501948
102TP53_22573176_ChIP-Seq_HFKS_Human0.82324738
103POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78691018
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77676851
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.74849693
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.74675931
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.73954985
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73409213
109IRF1_19129219_ChIP-ChIP_H3396_Human0.72924499
110TAF15_26573619_Chip-Seq_HEK293_Human0.72839784
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72183139
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.71859776
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.71317071
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70887782
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.70230799
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69922589
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69549122
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.67728189
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.66897290
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.66731720
121SALL1_21062744_ChIP-ChIP_HESCs_Human0.66364446
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.66333286
123FOXA1_25329375_ChIP-Seq_VCAP_Human0.66333286
124P300_19829295_ChIP-Seq_ESCs_Human0.65927898
125* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.65900205
126IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.65289104
127CTBP1_25329375_ChIP-Seq_LNCAP_Human0.65166425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.98122188
2MP0010094_abnormal_chromosome_stability5.35968055
3MP0008057_abnormal_DNA_replication4.85764792
4MP0004957_abnormal_blastocyst_morpholog4.75062717
5MP0003111_abnormal_nucleus_morphology4.73407010
6MP0003077_abnormal_cell_cycle4.36862943
7MP0008058_abnormal_DNA_repair3.95106593
8MP0008007_abnormal_cellular_replicative3.11246834
9MP0008932_abnormal_embryonic_tissue2.91428210
10MP0002396_abnormal_hematopoietic_system2.70943889
11MP0008877_abnormal_DNA_methylation2.51304118
12MP0003123_paternal_imprinting2.38592068
13MP0003786_premature_aging2.27109737
14MP0000350_abnormal_cell_proliferation2.24208597
15MP0001730_embryonic_growth_arrest2.20682455
16MP0002163_abnormal_gland_morphology2.04270822
17MP0000490_abnormal_crypts_of1.83160751
18MP0010307_abnormal_tumor_latency1.81477728
19MP0006072_abnormal_retinal_apoptosis1.80927599
20MP0003718_maternal_effect1.74940576
21MP0000372_irregular_coat_pigmentation1.73346391
22MP0010352_gastrointestinal_tract_polyps1.67802766
23MP0006292_abnormal_olfactory_placode1.66673747
24MP0001697_abnormal_embryo_size1.61115527
25MP0004808_abnormal_hematopoietic_stem1.57684146
26MP0001672_abnormal_embryogenesis/_devel1.54888829
27MP0005380_embryogenesis_phenotype1.54888829
28MP0000313_abnormal_cell_death1.52419671
29MP0003806_abnormal_nucleotide_metabolis1.51105672
30MP0002210_abnormal_sex_determination1.49392169
31MP0002019_abnormal_tumor_incidence1.49376550
32MP0002080_prenatal_lethality1.48662806
33MP0001545_abnormal_hematopoietic_system1.43262580
34MP0005397_hematopoietic_system_phenotyp1.43262580
35MP0001529_abnormal_vocalization1.38821434
36MP0009333_abnormal_splenocyte_physiolog1.38566428
37MP0002085_abnormal_embryonic_tissue1.34354108
38MP0003984_embryonic_growth_retardation1.33833498
39MP0001145_abnormal_male_reproductive1.29291930
40MP0002088_abnormal_embryonic_growth/wei1.29205920
41MP0003567_abnormal_fetal_cardiomyocyte1.23876272
42MP0003763_abnormal_thymus_physiology1.21219367
43MP0001929_abnormal_gametogenesis1.20645908
44MP0003186_abnormal_redox_activity1.20354714
45MP0008872_abnormal_physiological_respon1.19780984
46MP0004147_increased_porphyrin_level1.19492233
47MP0005379_endocrine/exocrine_gland_phen1.19151875
48MP0002084_abnormal_developmental_patter1.18815864
49MP0003315_abnormal_perineum_morphology1.17672931
50MP0002086_abnormal_extraembryonic_tissu1.16380119
51MP0003121_genomic_imprinting1.15277694
52MP0000653_abnormal_sex_gland1.14914855
53MP0002398_abnormal_bone_marrow1.10974084
54MP0002160_abnormal_reproductive_system1.09406327
55MP0000703_abnormal_thymus_morphology1.08956202
56MP0002837_dystrophic_cardiac_calcinosis1.08083492
57MP0002736_abnormal_nociception_after1.07887639
58MP0001293_anophthalmia1.07513112
59MP0002277_abnormal_respiratory_mucosa1.06245517
60MP0004197_abnormal_fetal_growth/weight/1.04687307
61MP0006054_spinal_hemorrhage1.02268463
62MP0002722_abnormal_immune_system1.01755581
63MP0003890_abnormal_embryonic-extraembry1.00871031
64MP0000689_abnormal_spleen_morphology1.00156782
65MP0005084_abnormal_gallbladder_morpholo0.99644237
66MP0001119_abnormal_female_reproductive0.99473835
67MP0009379_abnormal_foot_pigmentation0.95666404
68MP0008789_abnormal_olfactory_epithelium0.95520056
69MP0002653_abnormal_ependyma_morphology0.93353340
70MP0002095_abnormal_skin_pigmentation0.93254205
71MP0005253_abnormal_eye_physiology0.92579284
72MP0002132_abnormal_respiratory_system0.92248645
73MP0006036_abnormal_mitochondrial_physio0.91854180
74MP0009697_abnormal_copulation0.89667876
75MP0005551_abnormal_eye_electrophysiolog0.88748988
76MP0001485_abnormal_pinna_reflex0.88731157
77MP0005389_reproductive_system_phenotype0.88712466
78MP0000358_abnormal_cell_content/0.88377860
79MP0003195_calcinosis0.87824635
80MP0000631_abnormal_neuroendocrine_gland0.87281191
81MP0002429_abnormal_blood_cell0.85737850
82MP0000566_synostosis0.82947102
83MP0001853_heart_inflammation0.81413030
84MP0005075_abnormal_melanosome_morpholog0.80739046
85MP0002234_abnormal_pharynx_morphology0.76972307
86MP0001188_hyperpigmentation0.76718253
87MP0000049_abnormal_middle_ear0.76712985
88MP0005410_abnormal_fertilization0.75634154
89MP0005384_cellular_phenotype0.74405183
90MP0005174_abnormal_tail_pigmentation0.72654868
91MP0005646_abnormal_pituitary_gland0.71876439
92MP0004215_abnormal_myocardial_fiber0.71725550
93MP0000858_altered_metastatic_potential0.70574647
94MP0000647_abnormal_sebaceous_gland0.70259830
95MP0003656_abnormal_erythrocyte_physiolo0.69907803
96MP0000716_abnormal_immune_system0.69512700
97MP0005391_vision/eye_phenotype0.69207916
98MP0006035_abnormal_mitochondrial_morpho0.68929743
99MP0002938_white_spotting0.68877086
100MP0000015_abnormal_ear_pigmentation0.67475417
101MP0004133_heterotaxia0.67400324
102MP0009672_abnormal_birth_weight0.67110905
103MP0002102_abnormal_ear_morphology0.66935689
104MP0005621_abnormal_cell_physiology0.64866678
105MP0004264_abnormal_extraembryonic_tissu0.64305157
106MP0008995_early_reproductive_senescence0.64150935
107MP0003221_abnormal_cardiomyocyte_apopto0.63981106
108MP0002233_abnormal_nose_morphology0.62925048
109MP0002697_abnormal_eye_size0.62841583
110MP0005395_other_phenotype0.62432859
111MP0003698_abnormal_male_reproductive0.61923252
112MP0002138_abnormal_hepatobiliary_system0.60923140
113MP0010030_abnormal_orbit_morphology0.59985247
114MP0002075_abnormal_coat/hair_pigmentati0.59817836
115MP0005266_abnormal_metabolism0.58068126
116MP0001919_abnormal_reproductive_system0.57883444
117MP0001186_pigmentation_phenotype0.57101220
118MP0008875_abnormal_xenobiotic_pharmacok0.56503195
119MP0003941_abnormal_skin_development0.55445564
120MP0001881_abnormal_mammary_gland0.55332038
121MP0002111_abnormal_tail_morphology0.54981420
122MP0003699_abnormal_female_reproductive0.54720832
123MP0009703_decreased_birth_body0.53518490
124MP0002161_abnormal_fertility/fecundity0.53098082
125MP0002006_tumorigenesis0.52947380
126MP0000477_abnormal_intestine_morphology0.52881262
127MP0003136_yellow_coat_color0.51275901
128MP0001286_abnormal_eye_development0.51094190
129MP0005671_abnormal_response_to0.50853427
130MP0003937_abnormal_limbs/digits/tail_de0.50184918
131MP0005076_abnormal_cell_differentiation0.47797588
132MP0003119_abnormal_digestive_system0.47741020
133MP0001764_abnormal_homeostasis0.47618468

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.55694592
2Abnormality of cells of the erythroid lineage (HP:0012130)4.57775323
3Breast hypoplasia (HP:0003187)4.56580271
4Abnormal number of erythroid precursors (HP:0012131)4.50870170
5Chromsome breakage (HP:0040012)4.49633403
6Reticulocytopenia (HP:0001896)4.45205890
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.21168427
8Acute necrotizing encephalopathy (HP:0006965)4.01163811
9Oral leukoplakia (HP:0002745)3.96078440
10Aplastic anemia (HP:0001915)3.73326638
11Abnormality of chromosome stability (HP:0003220)3.71836317
12Acute encephalopathy (HP:0006846)3.61978039
13Patellar aplasia (HP:0006443)3.56765542
14Abnormal mitochondria in muscle tissue (HP:0008316)3.55562360
15Abnormality of the preputium (HP:0100587)3.54916930
16Increased CSF lactate (HP:0002490)3.48170181
17Meckel diverticulum (HP:0002245)3.46808902
18Mitochondrial inheritance (HP:0001427)3.38061166
19Colon cancer (HP:0003003)3.37362690
20Lipid accumulation in hepatocytes (HP:0006561)3.36212876
21Aplasia/Hypoplasia of the patella (HP:0006498)3.33106226
22Progressive macrocephaly (HP:0004481)3.32694276
23Abnormality of the ileum (HP:0001549)3.30470450
24Degeneration of anterior horn cells (HP:0002398)3.22080936
25Abnormality of the anterior horn cell (HP:0006802)3.22080936
26Increased hepatocellular lipid droplets (HP:0006565)3.14759465
27Aplasia/Hypoplasia of the uvula (HP:0010293)3.11462358
28Selective tooth agenesis (HP:0001592)3.06220052
29Carpal bone hypoplasia (HP:0001498)3.05167326
30Rough bone trabeculation (HP:0100670)3.03777762
31Medulloblastoma (HP:0002885)2.95730388
32Macrocytic anemia (HP:0001972)2.91337739
33Myelodysplasia (HP:0002863)2.89767150
34Microretrognathia (HP:0000308)2.87338963
35Absent thumb (HP:0009777)2.85933025
36Premature graying of hair (HP:0002216)2.84941004
37Pallor (HP:0000980)2.83558262
38Duodenal stenosis (HP:0100867)2.81814433
39Small intestinal stenosis (HP:0012848)2.81814433
40Cerebral hypomyelination (HP:0006808)2.81363100
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.80560909
42Abnormality of alanine metabolism (HP:0010916)2.80560909
43Hyperalaninemia (HP:0003348)2.80560909
44Bone marrow hypocellularity (HP:0005528)2.77301226
45Impulsivity (HP:0100710)2.77105550
4611 pairs of ribs (HP:0000878)2.77091050
47Hepatocellular necrosis (HP:0001404)2.74964096
48Cerebral edema (HP:0002181)2.72661912
49Agnosia (HP:0010524)2.66490918
50Methylmalonic acidemia (HP:0002912)2.61793956
51Absent radius (HP:0003974)2.57598013
52Hepatic necrosis (HP:0002605)2.53937873
53Pancreatic cysts (HP:0001737)2.53912055
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.45542653
55Ependymoma (HP:0002888)2.45073045
56Respiratory difficulties (HP:0002880)2.44297703
57Sloping forehead (HP:0000340)2.41506023
58Type I transferrin isoform profile (HP:0003642)2.40378066
59Aplasia involving forearm bones (HP:0009822)2.38936055
60Absent forearm bone (HP:0003953)2.38936055
61Pancreatic fibrosis (HP:0100732)2.37027642
62Abnormality of serum amino acid levels (HP:0003112)2.36273945
63Neoplasm of the pancreas (HP:0002894)2.36099792
64Lactic acidosis (HP:0003128)2.35095872
65Rhabdomyosarcoma (HP:0002859)2.34860896
66Pancytopenia (HP:0001876)2.34172546
673-Methylglutaconic aciduria (HP:0003535)2.33333711
68Horseshoe kidney (HP:0000085)2.32337277
69Abnormality of methionine metabolism (HP:0010901)2.31812321
70Renal Fanconi syndrome (HP:0001994)2.30792477
71Abnormality of the duodenum (HP:0002246)2.30366841
72Abnormal lung lobation (HP:0002101)2.28255007
73Supernumerary spleens (HP:0009799)2.28074188
74Slender long bone (HP:0003100)2.26938079
75Thrombocytosis (HP:0001894)2.26849577
76Cellular immunodeficiency (HP:0005374)2.24874682
77Triphalangeal thumb (HP:0001199)2.24573259
78Tracheoesophageal fistula (HP:0002575)2.23988435
79Abnormal spermatogenesis (HP:0008669)2.23545489
80Abnormality of the pons (HP:0007361)2.23308732
81Methylmalonic aciduria (HP:0012120)2.21424062
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19267974
83Hypoplasia of the pons (HP:0012110)2.19224969
84Duplicated collecting system (HP:0000081)2.19095583
85Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18968193
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18968193
87Abnormal trabecular bone morphology (HP:0100671)2.18411812
88Abnormal number of incisors (HP:0011064)2.16699126
89Abnormality of midbrain morphology (HP:0002418)2.16345008
90Molar tooth sign on MRI (HP:0002419)2.16345008
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.16302264
92Abnormality of the labia minora (HP:0012880)2.15284019
93Ectopic kidney (HP:0000086)2.14350132
94Clubbing of toes (HP:0100760)2.13799300
95Lymphoma (HP:0002665)2.10396672
96Atresia of the external auditory canal (HP:0000413)2.10055369
97Secondary amenorrhea (HP:0000869)2.09693703
98Hyperglycinemia (HP:0002154)2.09529088
99Abnormality of the carotid arteries (HP:0005344)2.08478146
100Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07487299
101Cleft eyelid (HP:0000625)2.06559804
102Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04994138
103Short thumb (HP:0009778)2.03920979
104Squamous cell carcinoma (HP:0002860)2.03730553
105Increased serum pyruvate (HP:0003542)2.02410374
106Respiratory failure (HP:0002878)2.01187930
107Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01039303
108Optic disc pallor (HP:0000543)2.00559284
109Abnormality of the renal collecting system (HP:0004742)1.98112126
110Lethargy (HP:0001254)1.98051833
111IgM deficiency (HP:0002850)1.95928113
112Basal cell carcinoma (HP:0002671)1.95640463
113Abnormality of DNA repair (HP:0003254)1.94693484
114Premature ovarian failure (HP:0008209)1.93578383
115Leukodystrophy (HP:0002415)1.93437999
116Exercise intolerance (HP:0003546)1.93155636
117Amaurosis fugax (HP:0100576)1.90194120
118Megaloblastic anemia (HP:0001889)1.89407140
119Nephroblastoma (Wilms tumor) (HP:0002667)1.89101576
120True hermaphroditism (HP:0010459)1.88668406
121Increased serum lactate (HP:0002151)1.87141321
122Medial flaring of the eyebrow (HP:0010747)1.86986246
123Trismus (HP:0000211)1.85910642
124Multiple enchondromatosis (HP:0005701)1.85884368
125Sclerocornea (HP:0000647)1.85529204
126Homocystinuria (HP:0002156)1.84934630
127Abnormality of homocysteine metabolism (HP:0010919)1.84934630
128Congenital, generalized hypertrichosis (HP:0004540)1.84014373
129Muscle fiber atrophy (HP:0100295)1.82531580
130Type II lissencephaly (HP:0007260)1.82174726
131Neoplasm of the colon (HP:0100273)1.79646047
132Type 2 muscle fiber atrophy (HP:0003554)1.79507997
133Microvesicular hepatic steatosis (HP:0001414)1.79012882
134Facial cleft (HP:0002006)1.78440672
135Volvulus (HP:0002580)1.78363198
136Septo-optic dysplasia (HP:0100842)1.77009136
137Irregular epiphyses (HP:0010582)1.76487637
138Abnormality of pyrimidine metabolism (HP:0004353)1.76389218
139Cafe-au-lait spot (HP:0000957)1.76115034
140Embryonal renal neoplasm (HP:0011794)1.75157592
141Poor head control (HP:0002421)1.75029708
142Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74954626
143Abnormal protein N-linked glycosylation (HP:0012347)1.74954626
144Abnormal protein glycosylation (HP:0012346)1.74954626
145Abnormal glycosylation (HP:0012345)1.74954626
146Pulmonary fibrosis (HP:0002206)1.74833496
147Hypoplasia of the radius (HP:0002984)1.74631796
148CNS hypomyelination (HP:0003429)1.74360080
149Facial hemangioma (HP:0000329)1.74223892
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.73472631
151Optic nerve coloboma (HP:0000588)1.73335215
152Nephronophthisis (HP:0000090)1.73083750
153Reduced antithrombin III activity (HP:0001976)1.71950459
154Increased intramyocellular lipid droplets (HP:0012240)1.71387038
155Hyperglycinuria (HP:0003108)1.68802006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.88755219
2WEE14.68575214
3BUB14.30458266
4EIF2AK13.46795220
5STK162.85001890
6SRPK12.80152596
7VRK22.77150206
8ACVR1B2.77035165
9BRSK22.65566180
10NEK22.58933077
11PLK42.57753999
12VRK12.41606482
13EIF2AK32.41080478
14NEK12.34202558
15TTK2.22449347
16NME22.13068732
17CCNB12.11892224
18BMPR1B2.10484075
19PLK12.10076922
20TRIM282.01988789
21MKNK11.97683204
22TSSK61.93749120
23ATR1.85704267
24AURKB1.76191819
25BRSK11.72976108
26CDK71.72494615
27DYRK31.70471782
28PLK31.68453543
29TNIK1.65507801
30PASK1.64150390
31TESK21.52203725
32MKNK21.51965782
33CHEK21.46736555
34RPS6KA41.37353913
35TLK11.37127957
36ZAK1.23599320
37WNK31.22599893
38RPS6KB21.22288720
39CDK81.22004295
40AURKA1.21754608
41MAP4K21.21597346
42MAP3K121.20929024
43TAF11.17460050
44CHEK11.16065065
45PDK21.11993052
46CDK41.11451084
47PNCK1.11185142
48MAP3K81.09997545
49OXSR11.09223300
50WNK41.07643219
51SCYL21.05795289
52STK41.03252763
53ADRBK21.03091633
54FRK0.98654624
55STK390.95524718
56EIF2AK20.94031963
57ATM0.87873478
58TGFBR10.82608087
59GRK10.82430570
60CDK20.79524745
61CSNK2A10.78225253
62PIM10.76355348
63CSNK2A20.74456412
64PBK0.74230745
65STK100.73810410
66PIM20.73781562
67BRAF0.73249386
68FLT30.71716231
69TEC0.69257264
70CASK0.68001474
71PLK20.67382596
72PAK40.66258853
73CSNK1G10.64452587
74CDK10.62253870
75KDR0.60417150
76MELK0.58352825
77INSRR0.55332986
78RPS6KA50.54737661
79CDK30.52966687
80CLK10.51180437
81PAK10.50447969
82EPHA20.50010791
83MST40.49210650
84CSNK1G30.49041500
85CDK120.49015140
86BCR0.48919631
87MAP4K10.47912177
88TESK10.47262801
89LRRK20.47235721
90CSNK1A10.46682624
91BRD40.44739407
92BTK0.43426481
93BCKDK0.41094153
94DYRK20.39462874
95CDK60.39241864
96MAP2K30.38858622
97ERBB30.38613108
98PRKCI0.38524556
99IRAK40.37945572
100NME10.37634113
101MAPKAPK50.37168784
102ERBB40.36825258
103ALK0.36709170
104YES10.34643427
105STK30.34008669
106CSNK1A1L0.33452415
107KIT0.33310055
108ABL20.32527851
109MAP3K90.32414239
110MAPK130.31682653
111PRKCQ0.30776131
112DAPK10.30694064
113MAPKAPK30.30048398
114CSNK1G20.29812842
115PRKDC0.29643749
116PRKCG0.28486869
117EEF2K0.26876101
118FGFR10.26242945
119CDK90.25663163
120MAP3K110.21778791
121LYN0.21235244
122ILK0.21081504
123ZAP700.20067825
124AKT20.19335396
125CSNK1E0.19106942
126PDK30.18907625
127PDK40.18907625
128TXK0.18725921
129MAPK140.18337087
130STK38L0.17821251
131NUAK10.17335613
132RAF10.16931826
133RPS6KB10.16547301
134CSF1R0.16296956
135CDK190.16114646

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.70677169
2Mismatch repair_Homo sapiens_hsa034304.71150175
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61576942
4Ribosome_Homo sapiens_hsa030103.49072533
5RNA polymerase_Homo sapiens_hsa030203.47691216
6Homologous recombination_Homo sapiens_hsa034403.45203987
7Proteasome_Homo sapiens_hsa030503.31858787
8Spliceosome_Homo sapiens_hsa030403.22208721
9Base excision repair_Homo sapiens_hsa034103.20365983
10Nucleotide excision repair_Homo sapiens_hsa034203.15319207
11RNA transport_Homo sapiens_hsa030132.95624971
12Cell cycle_Homo sapiens_hsa041102.80277791
13Pyrimidine metabolism_Homo sapiens_hsa002402.78184703
14Fanconi anemia pathway_Homo sapiens_hsa034602.48467525
15One carbon pool by folate_Homo sapiens_hsa006702.39663223
16Non-homologous end-joining_Homo sapiens_hsa034502.30694819
17Basal transcription factors_Homo sapiens_hsa030222.11483359
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08731125
19RNA degradation_Homo sapiens_hsa030182.00718543
20Propanoate metabolism_Homo sapiens_hsa006401.56782921
21Purine metabolism_Homo sapiens_hsa002301.56731798
22p53 signaling pathway_Homo sapiens_hsa041151.55861334
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53538232
24mRNA surveillance pathway_Homo sapiens_hsa030151.51303760
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31277418
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27016595
27Protein export_Homo sapiens_hsa030601.25430033
28Pyruvate metabolism_Homo sapiens_hsa006201.16772331
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12133649
30Epstein-Barr virus infection_Homo sapiens_hsa051691.08320874
31Systemic lupus erythematosus_Homo sapiens_hsa053221.05326519
32Folate biosynthesis_Homo sapiens_hsa007900.98524045
33Phototransduction_Homo sapiens_hsa047440.92930404
34Vitamin B6 metabolism_Homo sapiens_hsa007500.89249798
35Oocyte meiosis_Homo sapiens_hsa041140.89068273
36Herpes simplex infection_Homo sapiens_hsa051680.88594563
37Fatty acid elongation_Homo sapiens_hsa000620.81877290
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.80305696
39Huntingtons disease_Homo sapiens_hsa050160.79415246
40Antigen processing and presentation_Homo sapiens_hsa046120.77792502
41Steroid biosynthesis_Homo sapiens_hsa001000.77233170
42Pentose phosphate pathway_Homo sapiens_hsa000300.75177164
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74930654
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74880920
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73729824
46Viral carcinogenesis_Homo sapiens_hsa052030.73017368
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.70782564
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69177211
49Parkinsons disease_Homo sapiens_hsa050120.68618320
50Cardiac muscle contraction_Homo sapiens_hsa042600.67918191
51Selenocompound metabolism_Homo sapiens_hsa004500.66381869
52Caffeine metabolism_Homo sapiens_hsa002320.63238499
53Nitrogen metabolism_Homo sapiens_hsa009100.62902752
54Butanoate metabolism_Homo sapiens_hsa006500.62678732
55Biosynthesis of amino acids_Homo sapiens_hsa012300.62104113
56Sulfur relay system_Homo sapiens_hsa041220.58814309
57Tryptophan metabolism_Homo sapiens_hsa003800.57669366
58Glutathione metabolism_Homo sapiens_hsa004800.57605985
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.56093316
60Peroxisome_Homo sapiens_hsa041460.55612667
61HTLV-I infection_Homo sapiens_hsa051660.55401043
62N-Glycan biosynthesis_Homo sapiens_hsa005100.51341521
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50854817
64Primary immunodeficiency_Homo sapiens_hsa053400.50650741
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49674085
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47770684
67Oxidative phosphorylation_Homo sapiens_hsa001900.45715037
68Thyroid cancer_Homo sapiens_hsa052160.45066713
69Sulfur metabolism_Homo sapiens_hsa009200.44593347
70Legionellosis_Homo sapiens_hsa051340.40806768
71Small cell lung cancer_Homo sapiens_hsa052220.40660686
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40477875
73Fatty acid degradation_Homo sapiens_hsa000710.40182757
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38938346
75Vitamin digestion and absorption_Homo sapiens_hsa049770.37754588
76Fatty acid metabolism_Homo sapiens_hsa012120.37485508
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34709544
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.34160894
79Alcoholism_Homo sapiens_hsa050340.33416501
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32738030
81MicroRNAs in cancer_Homo sapiens_hsa052060.31105052
82Carbon metabolism_Homo sapiens_hsa012000.30750189
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30680601
84Metabolic pathways_Homo sapiens_hsa011000.30038907
85Chemical carcinogenesis_Homo sapiens_hsa052040.29872381
86Olfactory transduction_Homo sapiens_hsa047400.29765806
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29221666
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28855811
89Measles_Homo sapiens_hsa051620.27909388
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27798655
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27614181
92Retinol metabolism_Homo sapiens_hsa008300.26989863
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26929873
94Apoptosis_Homo sapiens_hsa042100.26417130
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25706268
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25453915
97Hepatitis B_Homo sapiens_hsa051610.23596651
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23564309
99Hematopoietic cell lineage_Homo sapiens_hsa046400.22524669
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22478149
101TGF-beta signaling pathway_Homo sapiens_hsa043500.21781397
102Arachidonic acid metabolism_Homo sapiens_hsa005900.20144043
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20089899
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.19379363
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18628410
106Galactose metabolism_Homo sapiens_hsa000520.18509325
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.18486974
108beta-Alanine metabolism_Homo sapiens_hsa004100.18072980
109Renin-angiotensin system_Homo sapiens_hsa046140.17478453
110Collecting duct acid secretion_Homo sapiens_hsa049660.16726400
111Colorectal cancer_Homo sapiens_hsa052100.16649967
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16092325
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16006766
114Shigellosis_Homo sapiens_hsa051310.15239381
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.15110989
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13640002
117Fructose and mannose metabolism_Homo sapiens_hsa000510.13280972
118Alzheimers disease_Homo sapiens_hsa050100.13113185
119Influenza A_Homo sapiens_hsa051640.12527198
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.11266256
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.09738859
122Lysine degradation_Homo sapiens_hsa003100.09279686
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09264744
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07471975
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07147830
126Pathways in cancer_Homo sapiens_hsa052000.06978979
127Asthma_Homo sapiens_hsa053100.05629518
128Other glycan degradation_Homo sapiens_hsa005110.04970072
129Bladder cancer_Homo sapiens_hsa052190.03410646
130Allograft rejection_Homo sapiens_hsa053300.03330515
131HIF-1 signaling pathway_Homo sapiens_hsa040660.02852204
132Hippo signaling pathway_Homo sapiens_hsa043900.02039977
133Regulation of autophagy_Homo sapiens_hsa041400.01754751
134Linoleic acid metabolism_Homo sapiens_hsa00591-6.6722765
135Basal cell carcinoma_Homo sapiens_hsa05217-0.0042017
136Arginine and proline metabolism_Homo sapiens_hsa00330-0.0032914
137Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0012870

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