TIPARP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of RIG-I signaling pathway (GO:0039535)5.13722271
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.54350202
3regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.35252061
4regulation of vitamin D biosynthetic process (GO:0060556)4.29844803
5mitotic metaphase plate congression (GO:0007080)4.29762484
6regulation of meiosis I (GO:0060631)4.28557123
7myoblast migration (GO:0051451)4.21497783
8meiotic chromosome segregation (GO:0045132)4.10061891
9negative regulation of hormone metabolic process (GO:0032351)4.08239534
10negative regulation of hormone biosynthetic process (GO:0032353)4.08239534
11regulation of mononuclear cell migration (GO:0071675)3.96257370
12metaphase plate congression (GO:0051310)3.89005004
13positive regulation of p38MAPK cascade (GO:1900745)3.74296451
14monoubiquitinated protein deubiquitination (GO:0035520)3.68656015
15regulation of retinoic acid receptor signaling pathway (GO:0048385)3.66494998
16regulation of glucocorticoid metabolic process (GO:0031943)3.63009750
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62863943
18regulation of meiosis (GO:0040020)3.62421843
19hemidesmosome assembly (GO:0031581)3.61865003
20regulation of histone H3-K27 methylation (GO:0061085)3.59837210
21establishment of chromosome localization (GO:0051303)3.57130738
22negative regulation of alcohol biosynthetic process (GO:1902931)3.53306968
23cell adhesion mediated by integrin (GO:0033627)3.51834530
24female gamete generation (GO:0007292)3.41176476
25regulation of vitamin metabolic process (GO:0030656)3.40810627
26negative regulation of meiosis (GO:0045835)3.38712593
27piRNA metabolic process (GO:0034587)3.35787020
28membrane raft organization (GO:0031579)3.35519489
29positive regulation of megakaryocyte differentiation (GO:0045654)3.34721826
30oocyte maturation (GO:0001556)3.33255113
31notochord development (GO:0030903)3.30444173
32regulation of female gonad development (GO:2000194)3.29686736
33protein K6-linked ubiquitination (GO:0085020)3.28668457
34meiotic cell cycle (GO:0051321)3.23139803
35negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.20631874
36DNA damage induced protein phosphorylation (GO:0006975)3.18399235
37DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.18332549
38protein localization to endosome (GO:0036010)3.16382359
39skin morphogenesis (GO:0043589)3.13884580
40mitotic chromosome condensation (GO:0007076)3.13567082
41maturation of 5.8S rRNA (GO:0000460)3.10834444
42DNA damage response, signal transduction resulting in transcription (GO:0042772)3.10090050
43regulation of exit from mitosis (GO:0007096)3.06229932
44cellular response to gamma radiation (GO:0071480)3.02339440
45nuclear pore complex assembly (GO:0051292)3.01149401
46response to peptidoglycan (GO:0032494)3.00965192
47positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.99591380
48regulation of transforming growth factor beta2 production (GO:0032909)2.97064700
49regulation of meiotic cell cycle (GO:0051445)2.96152078
50negative regulation of smooth muscle cell differentiation (GO:0051151)2.92141699
51regulation of T-helper 1 cell differentiation (GO:0045625)2.90539370
52response to muramyl dipeptide (GO:0032495)2.88091063
53regulation of transforming growth factor beta1 production (GO:0032908)2.85779057
54response to laminar fluid shear stress (GO:0034616)2.85238937
55histone H2A monoubiquitination (GO:0035518)2.85236951
56regulation of establishment of cell polarity (GO:2000114)2.84941276
57regulation of spindle organization (GO:0090224)2.83213474
58lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79585207
59protein localization to chromosome, centromeric region (GO:0071459)2.79581057
60attachment of spindle microtubules to kinetochore (GO:0008608)2.79404655
61male meiosis (GO:0007140)2.78927185
62regulation of p38MAPK cascade (GO:1900744)2.78450416
63regulation of steroid hormone biosynthetic process (GO:0090030)2.76188213
64positive regulation of chemokine biosynthetic process (GO:0045080)2.75242151
65natural killer cell mediated cytotoxicity (GO:0042267)2.74521244
66natural killer cell mediated immunity (GO:0002228)2.74521244
67regulation of sister chromatid cohesion (GO:0007063)2.73764611
68regulation of keratinocyte differentiation (GO:0045616)2.71649767
69hypotonic response (GO:0006971)2.71323773
70Rap protein signal transduction (GO:0032486)2.69827792
71wound healing, spreading of cells (GO:0044319)2.67210507
72negative regulation of interleukin-12 production (GO:0032695)2.66910612
73positive regulation of DNA-dependent DNA replication (GO:2000105)2.66557612
74cytoplasmic mRNA processing body assembly (GO:0033962)2.66447336
75embryonic process involved in female pregnancy (GO:0060136)2.66304987
76regulation of mitotic spindle organization (GO:0060236)2.65924985
77CENP-A containing nucleosome assembly (GO:0034080)2.65648260
78regulation of interferon-alpha production (GO:0032647)2.64984372
79type B pancreatic cell development (GO:0003323)2.64802294
80protein localization to kinetochore (GO:0034501)2.64338433
81chromatin remodeling at centromere (GO:0031055)2.63099580
82protein localization to chromosome (GO:0034502)2.62344337
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62315984
84positive regulation of mitotic sister chromatid separation (GO:1901970)2.61783240
85positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.61783240
86positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.61783240
87cellular response to arsenic-containing substance (GO:0071243)2.61681232
88negative regulation of nitric oxide biosynthetic process (GO:0045019)2.61341192
89production of molecular mediator involved in inflammatory response (GO:0002532)2.60509318
90activation of MAPKKK activity (GO:0000185)2.60488911
91negative regulation of homotypic cell-cell adhesion (GO:0034111)2.59381030
92positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59371989
93interleukin-6-mediated signaling pathway (GO:0070102)2.59020363
94desmosome organization (GO:0002934)2.58010065
95establishment of endothelial barrier (GO:0061028)2.57880273
96sister chromatid cohesion (GO:0007062)2.56955226
97chromosome segregation (GO:0007059)2.56609608
98regulation of membrane protein ectodomain proteolysis (GO:0051043)2.56386999
99regulation of mitotic spindle checkpoint (GO:1903504)2.56370522
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.56370522
101regulation of chemokine biosynthetic process (GO:0045073)2.56124182
102positive regulation of extracellular matrix organization (GO:1903055)2.55250362
103regulation of centriole replication (GO:0046599)2.51527064
104positive regulation of Cdc42 GTPase activity (GO:0043089)2.51002573
105mitotic sister chromatid cohesion (GO:0007064)2.49028467
106negative regulation of meiotic cell cycle (GO:0051447)2.48972724
107regulation of chronic inflammatory response (GO:0002676)2.48202017
108mitotic G2/M transition checkpoint (GO:0044818)2.47407981
109keratinocyte proliferation (GO:0043616)2.46705490
110mitotic sister chromatid segregation (GO:0000070)2.46700610
111nuclear pore organization (GO:0006999)2.45928500
112cellular response to type I interferon (GO:0071357)2.45782923
113type I interferon signaling pathway (GO:0060337)2.45782923
114regulation of cytokine secretion involved in immune response (GO:0002739)2.45606567
115mitotic nuclear envelope disassembly (GO:0007077)2.44404648
116cell-substrate junction assembly (GO:0007044)2.43612195
117mature B cell differentiation involved in immune response (GO:0002313)2.43607478
118response to type I interferon (GO:0034340)2.42982723
119pathway-restricted SMAD protein phosphorylation (GO:0060389)2.42291488
120regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.41248627
121immunoglobulin mediated immune response (GO:0016064)2.41233093
122positive regulation of interferon-alpha production (GO:0032727)2.40923860
123mRNA transcription (GO:0009299)2.40863727
124ovulation (GO:0030728)2.40713981
125* platelet-derived growth factor receptor signaling pathway (GO:0048008)2.39854887
126positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.39390772
127regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.39230028
128positive regulation of natural killer cell activation (GO:0032816)2.39105861
129positive regulation of endothelial cell apoptotic process (GO:2000353)2.38387104
130negative regulation of keratinocyte proliferation (GO:0010839)2.37942093
131response to progesterone (GO:0032570)2.37222920
132membrane disassembly (GO:0030397)2.37082173
133nuclear envelope disassembly (GO:0051081)2.37082173
134regulation of interferon-beta biosynthetic process (GO:0045357)2.36850515
135parturition (GO:0007567)2.35778195
136regulation of establishment or maintenance of cell polarity (GO:0032878)2.35694304
137N-terminal protein amino acid acetylation (GO:0006474)2.35688016
138negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.35208099
139superoxide anion generation (GO:0042554)2.34962511
140DNA replication-independent nucleosome organization (GO:0034724)2.34915368
141DNA replication-independent nucleosome assembly (GO:0006336)2.34915368
142NIK/NF-kappaB signaling (GO:0038061)2.34581444
143ovulation from ovarian follicle (GO:0001542)2.34553984
144positive regulation of chromosome segregation (GO:0051984)2.34331599
145pore complex assembly (GO:0046931)2.33894442
146regulation of nitric oxide biosynthetic process (GO:0045428)2.33582718
147spindle checkpoint (GO:0031577)2.33469115
148response to protozoan (GO:0001562)2.33091965
149positive regulation of keratinocyte differentiation (GO:0045618)2.32948345
150histone demethylation (GO:0016577)2.32372031
151centriole replication (GO:0007099)2.32164387
152regulation of integrin-mediated signaling pathway (GO:2001044)2.32131964
153regulation of T-helper 2 cell differentiation (GO:0045628)2.31677944
154modulation by symbiont of host immune response (GO:0052553)2.31166373
155positive regulation by symbiont of host defense response (GO:0052509)2.31166373
156modulation by symbiont of host defense response (GO:0052031)2.31166373
157modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.31166373
158positive regulation by organism of defense response of other organism involved in symbiotic interact2.31166373
159regulation of transforming growth factor beta production (GO:0071634)2.29285473
160germinal center formation (GO:0002467)2.28997895
161low-density lipoprotein particle clearance (GO:0034383)2.28948081
162positive regulation of nitric oxide biosynthetic process (GO:0045429)2.27295273
163positive regulation of transforming growth factor beta production (GO:0071636)2.26761033
164negative regulation of anoikis (GO:2000811)2.25350788
165positive regulation of heat generation (GO:0031652)2.25197467
166regulation of fever generation (GO:0031620)2.25061603
167mannose metabolic process (GO:0006013)2.24966320
168macrophage activation involved in immune response (GO:0002281)2.24828028
169regulation of podosome assembly (GO:0071801)2.23367103
170stress fiber assembly (GO:0043149)2.22692846
171JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.22027051
172surfactant homeostasis (GO:0043129)2.21527366
173regulation of T-helper cell differentiation (GO:0045622)2.20326332
174decidualization (GO:0046697)2.19934797
175positive regulation of interferon-beta production (GO:0032728)2.19893043
176branching involved in labyrinthine layer morphogenesis (GO:0060670)2.19867331
177negative regulation of lipid storage (GO:0010888)2.19528551
178mammary gland epithelial cell proliferation (GO:0033598)2.18539502
179regulation of anoikis (GO:2000209)2.17956492
180wound healing, spreading of epidermal cells (GO:0035313)2.17159732
181negative regulation of fatty acid transport (GO:2000192)2.16749894
182CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.16189075
183defense response to protozoan (GO:0042832)2.15975801
184regulation of dendritic cell antigen processing and presentation (GO:0002604)2.15944548
185pericardium development (GO:0060039)2.14700199
186T-helper 1 type immune response (GO:0042088)2.13512752
187negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.13169753
188negative regulation of neurotransmitter secretion (GO:0046929)2.12929660
189positive regulation of interleukin-6 production (GO:0032755)2.11486034
190regulation of type I interferon-mediated signaling pathway (GO:0060338)2.10696611
191regulation of heterotypic cell-cell adhesion (GO:0034114)2.10672133
192negative regulation of erythrocyte differentiation (GO:0045647)2.09445735
193regulation of interleukin-8 biosynthetic process (GO:0045414)2.08821126
194cellular response to lipopolysaccharide (GO:0071222)2.08725996
195positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.08616964
196positive regulation of astrocyte differentiation (GO:0048711)2.08070602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.31321461
2E2F7_22180533_ChIP-Seq_HELA_Human4.71184068
3SMAD_19615063_ChIP-ChIP_OVARY_Human4.23860082
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.53203775
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.98525666
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.88773361
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.84539074
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.75680107
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.49083252
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.44777415
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.42676942
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42215471
13KAP1_22055183_ChIP-Seq_ESCs_Mouse2.33638117
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31589192
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19547588
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.17203559
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.09513896
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08861286
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.97628784
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95109767
21CLOCK_20551151_ChIP-Seq_293T_Human1.94656946
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.94521542
23AR_21909140_ChIP-Seq_LNCAP_Human1.93798415
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93202234
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.92191096
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.89226647
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82964599
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.79109339
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72953790
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67815890
31* ESR2_21235772_ChIP-Seq_MCF-7_Human1.65627914
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64957622
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63178333
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60777303
35CJUN_26792858_Chip-Seq_BT549_Human1.59039298
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58894555
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57815186
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57323740
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.57169954
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57052714
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.55382858
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53410280
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50881809
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47796397
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46795750
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45150756
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41767555
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40992222
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39500004
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39497729
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36058378
52* IRF8_27001747_Chip-Seq_BMDM_Mouse1.35894593
53RUNX_20019798_ChIP-Seq_JUKART_Human1.35571270
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34889470
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34564949
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34564949
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33827644
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33817341
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32696376
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32535211
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.32489637
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31624680
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30540123
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.29258105
65* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29036458
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28832820
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27727698
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.26933319
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.26266441
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.25822818
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25818993
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25329365
73VDR_24763502_ChIP-Seq_THP-1_Human1.23793635
74AHR_22903824_ChIP-Seq_MCF-7_Human1.21796787
75TP53_18474530_ChIP-ChIP_U2OS_Human1.21132246
76SOX2_20726797_ChIP-Seq_SW620_Human1.18932428
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18856697
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.17139919
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17091158
80* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16889778
81* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15829714
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14466248
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13304198
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10683503
85* TCF7_22412390_ChIP-Seq_EML_Mouse1.10470490
86* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10131482
87* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10131482
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10099739
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10017663
90* BRD4_25478319_ChIP-Seq_HGPS_Human1.09244023
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09106816
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.08722392
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08617958
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07884382
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.07790747
96PU_27001747_Chip-Seq_BMDM_Mouse1.07260069
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.06082880
98LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05575018
99* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05206700
100VDR_24787735_ChIP-Seq_THP-1_Human1.05125997
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04957715
102ATF3_27146783_Chip-Seq_COLON_Human1.04956685
103CDX2_22108803_ChIP-Seq_LS180_Human1.04261670
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03017791
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02598226
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02340966
107TBX20_22080862_ChIP-Seq_HEART_Mouse1.01036483
108TBX20_22328084_ChIP-Seq_HEART_Mouse1.01036483
109P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99488396
110* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98731886
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.98713002
112GATA1_26923725_Chip-Seq_HPCs_Mouse0.97549554
113MYB_26560356_Chip-Seq_TH1_Human0.97423705
114LXR_22158963_ChIP-Seq_LIVER_Mouse0.96696403
115EWS_26573619_Chip-Seq_HEK293_Human0.94320354
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93910174
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93678115
118FUS_26573619_Chip-Seq_HEK293_Human0.93492992
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92451150
120* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92212454
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91311295
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91056051
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90591531
124MYB_26560356_Chip-Seq_TH2_Human0.90093415
125RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89640755
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89326736
127NMYC_18555785_Chip-Seq_ESCs_Mouse0.88863857
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88696055
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88675478
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.87745290
131* TP63_23658742_ChIP-Seq_EP156T_Human0.83753814
132STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83430205
133JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83157414
134KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82412612
135KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82412612
136KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82412612
137* STAT3_18555785_Chip-Seq_ESCs_Mouse0.81757052
138NOTCH1_21737748_ChIP-Seq_TLL_Human0.81328817
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81302359
140TP53_16413492_ChIP-PET_HCT116_Human0.81103932
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80666716
142RXR_22108803_ChIP-Seq_LS180_Human0.79702546
143CMYC_18555785_Chip-Seq_ESCs_Mouse0.79450225
144SOX2_18555785_Chip-Seq_ESCs_Mouse0.79104642
145SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78264407
146ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78222451
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77796893
148STAT1_17558387_ChIP-Seq_HELA_Human0.77182335
149PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76666699
150MYC_18940864_ChIP-ChIP_HL60_Human0.76479005
151* E2F1_18555785_Chip-Seq_ESCs_Mouse0.75999111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.46485540
2MP0005451_abnormal_body_composition3.32491247
3MP0003300_gastrointestinal_ulcer2.67874246
4MP0003693_abnormal_embryo_hatching2.67310416
5MP0003646_muscle_fatigue2.60900560
6MP0002877_abnormal_melanocyte_morpholog2.53485971
7MP0003718_maternal_effect2.52690581
8MP0008438_abnormal_cutaneous_collagen2.46036716
9MP0008007_abnormal_cellular_replicative2.15938925
10MP0009840_abnormal_foam_cell2.08097084
11MP0006054_spinal_hemorrhage2.03687302
12MP0003724_increased_susceptibility_to2.03427393
13MP0003077_abnormal_cell_cycle2.03260285
14MP0003705_abnormal_hypodermis_morpholog2.02207823
15MP0003191_abnormal_cellular_cholesterol1.97258185
16MP0010094_abnormal_chromosome_stability1.92901788
17MP0010307_abnormal_tumor_latency1.88386085
18MP0005275_abnormal_skin_tensile1.84719994
19MP0005408_hypopigmentation1.80702698
20MP0003111_abnormal_nucleus_morphology1.78459477
21MP0008877_abnormal_DNA_methylation1.76796154
22MP0003656_abnormal_erythrocyte_physiolo1.76688609
23MP0001851_eye_inflammation1.75385465
24* MP0001119_abnormal_female_reproductive1.71219743
25MP0008057_abnormal_DNA_replication1.70753233
26MP0003448_altered_tumor_morphology1.68646600
27MP0002332_abnormal_exercise_endurance1.67803337
28MP0008004_abnormal_stomach_pH1.64674291
29MP0010368_abnormal_lymphatic_system1.62627386
30MP0002148_abnormal_hypersensitivity_rea1.59619508
31MP0000490_abnormal_crypts_of1.49161864
32MP0005395_other_phenotype1.46723641
33MP0003123_paternal_imprinting1.45158732
34MP0003436_decreased_susceptibility_to1.43185089
35MP0003828_pulmonary_edema1.42016171
36MP0005623_abnormal_meninges_morphology1.41535044
37MP0001835_abnormal_antigen_presentation1.41327828
38MP0003453_abnormal_keratinocyte_physiol1.40851177
39MP0005000_abnormal_immune_tolerance1.39727033
40MP0003303_peritoneal_inflammation1.37716278
41MP0005076_abnormal_cell_differentiation1.36256794
42MP0002405_respiratory_system_inflammati1.34338367
43MP0009785_altered_susceptibility_to1.33864844
44MP0002419_abnormal_innate_immunity1.33131697
45MP0002006_tumorigenesis1.33092401
46MP0000685_abnormal_immune_system1.32597027
47MP0002653_abnormal_ependyma_morphology1.31136934
48MP0001542_abnormal_bone_strength1.30567032
49MP0000858_altered_metastatic_potential1.30478518
50MP0004272_abnormal_basement_membrane1.27063795
51MP0002452_abnormal_antigen_presenting1.26953719
52MP0003045_fibrosis1.26171052
53MP0008961_abnormal_basal_metabolism1.24449313
54MP0003091_abnormal_cell_migration1.24367955
55MP0003937_abnormal_limbs/digits/tail_de1.21456846
56MP0005023_abnormal_wound_healing1.21068704
57MP0002166_altered_tumor_susceptibility1.19954266
58MP0010678_abnormal_skin_adnexa1.18450153
59MP0003787_abnormal_imprinting1.18390799
60MP0004510_myositis1.17726213
61MP0005310_abnormal_salivary_gland1.17503350
62MP0004957_abnormal_blastocyst_morpholog1.16906252
63MP0010352_gastrointestinal_tract_polyps1.16834133
64MP0002249_abnormal_larynx_morphology1.16451031
65* MP0003699_abnormal_female_reproductive1.16249858
66MP0000343_altered_response_to1.15453293
67MP0001915_intracranial_hemorrhage1.14402871
68MP0009250_abnormal_appendicular_skeleto1.13744653
69* MP0005390_skeleton_phenotype1.13643614
70MP0003075_altered_response_to1.12905264
71MP0001545_abnormal_hematopoietic_system1.12518753
72MP0005397_hematopoietic_system_phenotyp1.12518753
73MP0001800_abnormal_humoral_immune1.12432230
74MP0001790_abnormal_immune_system1.11367793
75MP0005387_immune_system_phenotype1.11367793
76MP0003786_premature_aging1.10886782
77MP0000350_abnormal_cell_proliferation1.09821691
78MP0001533_abnormal_skeleton_physiology1.09713427
79MP0000566_synostosis1.08218722
80MP0002210_abnormal_sex_determination1.08112795
81MP0003279_aneurysm1.07623355
82MP0005165_increased_susceptibility_to1.07522241
83MP0001853_heart_inflammation1.06160580
84MP0003763_abnormal_thymus_physiology1.04819578
85MP0001958_emphysema1.03167397
86MP0002723_abnormal_immune_serum1.02612350
87MP0009764_decreased_sensitivity_to1.02411182
88MP0001348_abnormal_lacrimal_gland1.01987600
89MP0003566_abnormal_cell_adhesion1.01987378
90MP0005257_abnormal_intraocular_pressure1.01486906
91MP0001346_abnormal_lacrimal_gland0.99740969
92MP0001819_abnormal_immune_cell0.99253082
93MP0002009_preneoplasia0.97977178
94MP0002420_abnormal_adaptive_immunity0.97969090
95MP0002138_abnormal_hepatobiliary_system0.97390357
96* MP0000767_abnormal_smooth_muscle0.97269336
97MP0004782_abnormal_surfactant_physiolog0.96882447
98* MP0000653_abnormal_sex_gland0.96604065
99MP0000627_abnormal_mammary_gland0.96437560
100MP0004808_abnormal_hematopoietic_stem0.96135903
101MP0009333_abnormal_splenocyte_physiolog0.95893582
102* MP0001845_abnormal_inflammatory_respons0.95706304
103MP0002019_abnormal_tumor_incidence0.94972945
104MP0005166_decreased_susceptibility_to0.94697447
105* MP0005508_abnormal_skeleton_morphology0.94544568
106MP0004947_skin_inflammation0.94050563
107MP0003136_yellow_coat_color0.93668815
108MP0010155_abnormal_intestine_physiology0.93548811
109MP0005164_abnormal_response_to0.93318429
110MP0005025_abnormal_response_to0.92365851
111MP0002933_joint_inflammation0.91975198
112MP0003950_abnormal_plasma_membrane0.91738184
113MP0006082_CNS_inflammation0.91535576
114MP0000733_abnormal_muscle_development0.90816226
115MP0002277_abnormal_respiratory_mucosa0.90622858
116MP0003941_abnormal_skin_development0.90564458
117MP0002282_abnormal_trachea_morphology0.90313325
118MP0004883_abnormal_blood_vessel0.89353041
119MP0002060_abnormal_skin_morphology0.88928299
120MP0002168_other_aberrant_phenotype0.88465934
121MP0008058_abnormal_DNA_repair0.88447461
122MP0005058_abnormal_lysosome_morphology0.87862138
123MP0002796_impaired_skin_barrier0.87846207
124MP0000372_irregular_coat_pigmentation0.87709620
125MP0006292_abnormal_olfactory_placode0.86473818
126MP0001929_abnormal_gametogenesis0.86192463
127MP0005375_adipose_tissue_phenotype0.85989783
128MP0001216_abnormal_epidermal_layer0.85927171
129MP0010234_abnormal_vibrissa_follicle0.85847683
130MP0001243_abnormal_dermal_layer0.85377293
131MP0000427_abnormal_hair_cycle0.84925439
132MP0004185_abnormal_adipocyte_glucose0.84583357
133MP0005621_abnormal_cell_physiology0.84136942
134MP0005248_abnormal_Harderian_gland0.82959092
135MP0002998_abnormal_bone_remodeling0.82674833
136MP0005666_abnormal_adipose_tissue0.81754393
137MP0001191_abnormal_skin_condition0.80896478
138MP0005595_abnormal_vascular_smooth0.80874294
139MP0009278_abnormal_bone_marrow0.80745170
140MP0008469_abnormal_protein_level0.79588829
141MP0000249_abnormal_blood_vessel0.78202209
142MP0003795_abnormal_bone_structure0.76503789
143MP0000383_abnormal_hair_follicle0.76455101
144MP0002896_abnormal_bone_mineralization0.75357617
145MP0005409_darkened_coat_color0.73953241

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.52574422
2Retrobulbar optic neuritis (HP:0100654)4.28178572
3Optic neuritis (HP:0100653)4.28178572
4Chromsome breakage (HP:0040012)3.91411653
5Flat capital femoral epiphysis (HP:0003370)3.83639418
6Orchitis (HP:0100796)3.78835259
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.56535094
8Myositis (HP:0100614)3.40261217
9Aortic aneurysm (HP:0004942)3.39634523
10Atrophic scars (HP:0001075)3.28679570
11Male infertility (HP:0003251)3.21095093
12Papillary thyroid carcinoma (HP:0002895)3.08336552
13Premature rupture of membranes (HP:0001788)3.07422377
14Abnormality of liposaccharide metabolism (HP:0010968)3.04099836
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.04099836
16Abnormality of glycolipid metabolism (HP:0010969)3.04099836
17Eczematoid dermatitis (HP:0000976)3.02340902
18Follicular hyperkeratosis (HP:0007502)2.99991396
19Adrenal hypoplasia (HP:0000835)2.98726079
20Osteolytic defects of the hand bones (HP:0009699)2.98226372
21Osteolytic defects of the phalanges of the hand (HP:0009771)2.98226372
22Thick nail (HP:0001805)2.97499391
23Acute myeloid leukemia (HP:0004808)2.94323449
24Capillary hemangiomas (HP:0005306)2.88102493
25Lip pit (HP:0100267)2.83637026
26Recurrent abscess formation (HP:0002722)2.79791911
27Birth length less than 3rd percentile (HP:0003561)2.76992646
28Aortic dissection (HP:0002647)2.74372649
29Interstitial pulmonary disease (HP:0006530)2.73999379
30Abnormality of the fingertips (HP:0001211)2.73968352
31Recurrent bacterial skin infections (HP:0005406)2.72716171
32Milia (HP:0001056)2.71051760
33Protrusio acetabuli (HP:0003179)2.64727372
34Spondylolisthesis (HP:0003302)2.63071981
35Onycholysis (HP:0001806)2.60416539
36Syringomyelia (HP:0003396)2.56387975
37Spinal cord lesions (HP:0100561)2.56387975
38Alopecia of scalp (HP:0002293)2.56092192
39Keratoconjunctivitis sicca (HP:0001097)2.54941975
40Irregular epiphyses (HP:0010582)2.46106144
41Facial hemangioma (HP:0000329)2.44913345
42Natal tooth (HP:0000695)2.44364515
43Abnormality of nail color (HP:0100643)2.42587408
44Abnormality of the prostate (HP:0008775)2.42210519
45Mediastinal lymphadenopathy (HP:0100721)2.40794991
46Breast hypoplasia (HP:0003187)2.35482265
47Keratoconjunctivitis (HP:0001096)2.28019491
48Autoimmune hemolytic anemia (HP:0001890)2.25767388
49Plantar hyperkeratosis (HP:0007556)2.23999015
50Loss of speech (HP:0002371)2.23886384
51Dilatation of the ascending aorta (HP:0005111)2.23344312
52Tetraparesis (HP:0002273)2.22713916
53Arterial tortuosity (HP:0005116)2.22270141
54Pulmonary infiltrates (HP:0002113)2.21776370
55Shawl scrotum (HP:0000049)2.21352157
56Subacute progressive viral hepatitis (HP:0006572)2.13648382
57Arterial thrombosis (HP:0004420)2.12862128
58Xerostomia (HP:0000217)2.11949289
59Abnormality of chromosome stability (HP:0003220)2.10800692
60Patellar aplasia (HP:0006443)2.10145401
61Abnormality of the epiphysis of the femoral head (HP:0010574)2.09343641
62Breast aplasia (HP:0100783)2.08976169
63Wormian bones (HP:0002645)2.08349727
64Abnormality of incisor morphology (HP:0011063)2.07971465
65Abnormality of femoral epiphyses (HP:0006499)2.07632263
66Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.07632263
67Hypoplasia of the fovea (HP:0007750)2.05588204
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.05588204
69Vertebral compression fractures (HP:0002953)2.05292487
70Dysostosis multiplex (HP:0000943)2.04650031
71Cardiovascular calcification (HP:0011915)2.04608594
72Myocardial infarction (HP:0001658)2.04398089
73Oligodactyly (hands) (HP:0001180)2.03688090
74Neurofibrillary tangles (HP:0002185)2.03110283
75Vascular tortuosity (HP:0004948)2.02251894
76Recurrent gram-negative bacterial infections (HP:0005420)2.01934263
77Aneurysm (HP:0002617)2.01348243
78Aplasia/Hypoplasia of the breasts (HP:0010311)2.01334155
79Entropion (HP:0000621)2.00858777
80Anhidrosis (HP:0000970)2.00129865
81Aplasia/Hypoplasia of the patella (HP:0006498)1.98769907
82Reduced subcutaneous adipose tissue (HP:0003758)1.98445024
83Abnormality of the femoral head (HP:0003368)1.97561127
84Abnormality of macrophages (HP:0004311)1.97059888
85Fragile skin (HP:0001030)1.96296326
86Thoracolumbar scoliosis (HP:0002944)1.95785140
87Aseptic necrosis (HP:0010885)1.95694631
88Abnormality of the proximal phalanges of the hand (HP:0009834)1.93561696
89Abnormality of male internal genitalia (HP:0000022)1.91808074
90Cervical subluxation (HP:0003308)1.89086470
91Vacuolated lymphocytes (HP:0001922)1.88442804
92Delayed epiphyseal ossification (HP:0002663)1.88410017
93Abnormality of the nasal septum (HP:0000419)1.88301640
94Right ventricular cardiomyopathy (HP:0011663)1.87385060
95Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86068402
96Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.86059036
97Nail dystrophy (HP:0008404)1.85506917
98Ectopic kidney (HP:0000086)1.85453786
99Glucose intolerance (HP:0000833)1.84421597
100Elbow flexion contracture (HP:0002987)1.84056367
101Stomatitis (HP:0010280)1.83969122
102Thyroid carcinoma (HP:0002890)1.83934123
103Ankyloglossia (HP:0010296)1.83561084
104Hypoplasia of the iris (HP:0007676)1.83039066
105Epiphyseal dysplasia (HP:0002656)1.82388762
106Mitral stenosis (HP:0001718)1.81663119
107Cystic hygroma (HP:0000476)1.81036523
108Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80705069
109Aplasia cutis congenita (HP:0001057)1.80317061
110Mucopolysacchariduria (HP:0008155)1.80121111
111Urinary glycosaminoglycan excretion (HP:0003541)1.80121111
112Carpal bone hypoplasia (HP:0001498)1.80033338
113Abnormality of the fovea (HP:0000493)1.79127496
114Clubbing of toes (HP:0100760)1.78217529
115Spinal rigidity (HP:0003306)1.78139655
116Autoimmune thrombocytopenia (HP:0001973)1.78121391
117Short nail (HP:0001799)1.77728390
118Oligodactyly (HP:0012165)1.77455782
119Cubitus valgus (HP:0002967)1.76802476
120Palmoplantar hyperkeratosis (HP:0000972)1.76244698
121Stillbirth (HP:0003826)1.74915562
122Exocrine pancreatic insufficiency (HP:0001738)1.74253410
123Enlarged epiphyses (HP:0010580)1.74220538
124Hypoplastic iliac wings (HP:0002866)1.73672050
125Hypergonadotropic hypogonadism (HP:0000815)1.72146515
126Abnormality of polysaccharide metabolism (HP:0011012)1.71094026
127Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71094026
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71094026
129Periodontitis (HP:0000704)1.70706447
130Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.70362312
131Microglossia (HP:0000171)1.69747004
132Absent frontal sinuses (HP:0002688)1.69671860
133Malnutrition (HP:0004395)1.69555114
134Abnormality of oral frenula (HP:0000190)1.68884418
135Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.68720627
136Segmental peripheral demyelination/remyelination (HP:0003481)1.67379918
137Abnormality of the labia minora (HP:0012880)1.66947638
138Corneal dystrophy (HP:0001131)1.66815616
139Abnormality of the phalanges of the hallux (HP:0010057)1.66630069
140Vascular calcification (HP:0004934)1.66497591
141Nuclear cataract (HP:0100018)1.66490476
142Stomach cancer (HP:0012126)1.66068176
143Hypoplastic ischia (HP:0003175)1.64568250
144Hematochezia (HP:0002573)1.64424921
145Pulmonary fibrosis (HP:0002206)1.63980212
146Abnormality of lateral ventricle (HP:0030047)1.63697389
147Aortic regurgitation (HP:0001659)1.63470949
148Ridged nail (HP:0001807)1.63153726
149Increased CSF protein (HP:0002922)1.63078122
150Abnormal blistering of the skin (HP:0008066)1.62896704
151Sparse lateral eyebrow (HP:0005338)1.62780688
152Distal lower limb muscle weakness (HP:0009053)1.62099375
153Abnormality of the phalanges of the 5th finger (HP:0004213)1.61338798
154Myelodysplasia (HP:0002863)1.61144791
155Vitreoretinal degeneration (HP:0000655)1.60895392
156Abnormality of the preputium (HP:0100587)1.60884990
157Small epiphyses (HP:0010585)1.60872254
158Recurrent viral infections (HP:0004429)1.60402508
159Abnormality of the distal phalanges of the toes (HP:0010182)1.59714361
160Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.59352709
161Neoplasm of the tracheobronchial system (HP:0100552)1.59337532
162Genu varum (HP:0002970)1.59221892
163Palmar hyperkeratosis (HP:0010765)1.58756129
164Aplasia/Hypoplasia of the uvula (HP:0010293)1.58526963
165Overgrowth (HP:0001548)1.58402214
166Advanced eruption of teeth (HP:0006288)1.58177473
167Meckel diverticulum (HP:0002245)1.58174317
168Fatigue (HP:0012378)1.58091242
169Blepharitis (HP:0000498)1.57107634
170Relative macrocephaly (HP:0004482)1.57106883
171Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.56812140
172Mitral valve prolapse (HP:0001634)1.55865541
173Anorexia (HP:0002039)1.52600047
174Aplasia involving bones of the extremities (HP:0009825)1.51627965
175Aplasia involving bones of the upper limbs (HP:0009823)1.51627965
176Aplasia of the phalanges of the hand (HP:0009802)1.51627965
177Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.50681377
178Ectropion (HP:0000656)1.49501851
179Cupped ribs (HP:0000887)1.49131656
180Abnormality of chromosome segregation (HP:0002916)1.48536340
181Azoospermia (HP:0000027)1.47864405
182Metaphyseal irregularity (HP:0003025)1.47607226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.33816614
2STK38L3.39186527
3PLK43.21488501
4ERBB43.11247048
5MUSK2.98402791
6LATS22.96273912
7AKT32.93826996
8EIF2AK32.77550318
9PRPF4B2.68390942
10MAP3K62.48802884
11STK32.26624521
12TGFBR22.20456433
13KSR22.19818553
14MST1R2.16929740
15RAF11.97329585
16TRPM71.95327722
17CDC71.91416517
18MAP3K141.86843354
19MAP3K131.85137510
20BMPR21.84149117
21MOS1.82067849
22TAOK11.81513681
23GRK71.77897566
24CDK91.76160757
25TAOK31.73843957
26JAK31.73725475
27BRAF1.71457486
28MST41.68913346
29TTK1.62988584
30NUAK11.61190660
31IRAK31.56747849
32DDR21.51838740
33MAPKAPK51.50355224
34PDGFRA1.49971733
35MELK1.49123196
36EEF2K1.48608908
37PBK1.44709539
38EPHA31.44304920
39PIM21.41854080
40ACVR1B1.39845807
41MET1.38907152
42CDK81.38441304
43TAOK21.38193787
44MAPKAPK31.36954898
45CHUK1.36155925
46SIK31.36129517
47IKBKE1.32102366
48PDK21.29580430
49STK241.29520240
50TXK1.28549713
51BMPR1B1.25260046
52IKBKB1.22357400
53FRK1.22253846
54ERN11.18937845
55KSR11.17131125
56ABL21.13552118
57PIM11.13512587
58MKNK11.11950236
59PTK21.11028996
60STK101.09316561
61NEK91.08171128
62ARAF1.07625710
63BRD41.05840747
64DMPK1.02560817
65RPS6KA41.01709051
66NLK1.01581362
67IRAK10.98797770
68EPHB10.97415729
69MKNK20.96170330
70MAP2K30.95524399
71DYRK20.95352805
72TTN0.95070163
73MAP3K50.94406530
74NEK20.92552620
75LMTK20.92460339
76MYLK0.91422138
77CHEK20.90738977
78CDK30.85629507
79TBK10.85381322
80PAK20.83949259
81MAP3K10.82589541
82ZAK0.80354359
83MAP3K90.79842889
84MAP3K30.79025230
85CDK120.78575262
86ZAP700.75383750
87RPS6KB20.74145266
88PLK10.73976264
89MAPK70.73403116
90MAP3K20.73212423
91YES10.73128140
92CDC42BPA0.72695949
93SIK10.72515184
94TYK20.71512664
95AURKB0.69797549
96WEE10.68666103
97STK380.68362247
98CSK0.68307468
99ABL10.67481620
100PLK30.66999905
101PIK3CG0.66634706
102STK40.66606754
103FER0.65371562
104MARK30.65005762
105ERBB30.64248815
106RIPK10.64147071
107CLK10.63566351
108ICK0.63422715
109MTOR0.63131205
110FGFR30.60674264
111GSK3A0.60150983
112FLT30.59514287
113PAK40.56458345
114TEC0.56134648
115PRKD20.55728522
116MAP3K80.54988543
117MAP3K120.54632698
118EIF2AK20.53810145
119SGK30.52882221
120JAK10.51941153
121BLK0.51711743
122IRAK20.51322290
123BRSK20.50209700
124CDK60.47439492
125HCK0.47258099
126TRIB30.47049065
127ATM0.45585758
128RIPK40.45541105
129CDK70.44655058
130VRK10.44453512
131CDK40.43854771
132PRKAA20.43090472
133INSR0.43028561
134MAPKAPK20.42913391
135CSF1R0.42584003
136RPS6KA50.42249439
137EPHA20.41357843
138SGK20.40633223
139JAK20.39478013
140HIPK20.39423493
141PAK60.38141189
142IRAK40.37708786
143TGFBR10.37144943
144ATR0.35226525
145CHEK10.34719012
146NEK60.32924465
147DYRK30.32239245
148KIT0.32042151
149PDGFRB0.32026345
150MAP4K10.31939950
151BUB10.31747084
152MAP2K10.30112525
153BMX0.28666257

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.48042458
2RNA degradation_Homo sapiens_hsa030182.01025863
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98474813
4Leishmaniasis_Homo sapiens_hsa051401.93451642
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.89684718
6TGF-beta signaling pathway_Homo sapiens_hsa043501.89270883
7p53 signaling pathway_Homo sapiens_hsa041151.89130877
8Basal transcription factors_Homo sapiens_hsa030221.85340154
9TNF signaling pathway_Homo sapiens_hsa046681.79585240
10Malaria_Homo sapiens_hsa051441.75262005
11Graft-versus-host disease_Homo sapiens_hsa053321.74391951
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74228105
13Ovarian steroidogenesis_Homo sapiens_hsa049131.68134548
14Pancreatic cancer_Homo sapiens_hsa052121.66915645
15Circadian rhythm_Homo sapiens_hsa047101.65103555
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62902915
17Herpes simplex infection_Homo sapiens_hsa051681.58982160
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50877605
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45885969
20Influenza A_Homo sapiens_hsa051641.43040359
21Measles_Homo sapiens_hsa051621.39927379
22Osteoclast differentiation_Homo sapiens_hsa043801.38958234
23Hepatitis B_Homo sapiens_hsa051611.38319187
24Homologous recombination_Homo sapiens_hsa034401.38130216
25MicroRNAs in cancer_Homo sapiens_hsa052061.37153176
26Prolactin signaling pathway_Homo sapiens_hsa049171.31917912
27RNA polymerase_Homo sapiens_hsa030201.25428464
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.24977562
29Rheumatoid arthritis_Homo sapiens_hsa053231.23792775
30Fanconi anemia pathway_Homo sapiens_hsa034601.23420495
31Toxoplasmosis_Homo sapiens_hsa051451.23034543
32Small cell lung cancer_Homo sapiens_hsa052221.22383273
33Legionellosis_Homo sapiens_hsa051341.22254304
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.22176839
35Allograft rejection_Homo sapiens_hsa053301.19055338
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17778809
37Focal adhesion_Homo sapiens_hsa045101.16308784
38Apoptosis_Homo sapiens_hsa042101.15276434
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14630919
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13374245
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11077052
42Hematopoietic cell lineage_Homo sapiens_hsa046401.09057304
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07111568
44Adherens junction_Homo sapiens_hsa045201.05185847
45Colorectal cancer_Homo sapiens_hsa052101.04033754
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03550120
47Tuberculosis_Homo sapiens_hsa051521.02372709
48Lysosome_Homo sapiens_hsa041421.01303766
49Dorso-ventral axis formation_Homo sapiens_hsa043201.01273050
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01231028
51FoxO signaling pathway_Homo sapiens_hsa040680.99659446
52HTLV-I infection_Homo sapiens_hsa051660.98605514
53Linoleic acid metabolism_Homo sapiens_hsa005910.98492061
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.98437275
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98146587
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97713898
57Chronic myeloid leukemia_Homo sapiens_hsa052200.96803761
58Shigellosis_Homo sapiens_hsa051310.94625425
59Base excision repair_Homo sapiens_hsa034100.93839679
60Ether lipid metabolism_Homo sapiens_hsa005650.89429575
61Autoimmune thyroid disease_Homo sapiens_hsa053200.88650654
62ErbB signaling pathway_Homo sapiens_hsa040120.88024467
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.87779575
64Non-homologous end-joining_Homo sapiens_hsa034500.87464316
65Salmonella infection_Homo sapiens_hsa051320.86855954
66Choline metabolism in cancer_Homo sapiens_hsa052310.86024753
67Prostate cancer_Homo sapiens_hsa052150.85826771
68mTOR signaling pathway_Homo sapiens_hsa041500.85689420
69Asthma_Homo sapiens_hsa053100.85687165
70Hippo signaling pathway_Homo sapiens_hsa043900.85460603
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.84794958
72Inositol phosphate metabolism_Homo sapiens_hsa005620.83215221
73Vitamin B6 metabolism_Homo sapiens_hsa007500.82049946
74Prion diseases_Homo sapiens_hsa050200.82035848
75Non-small cell lung cancer_Homo sapiens_hsa052230.81736075
76Arachidonic acid metabolism_Homo sapiens_hsa005900.81405270
77Renal cell carcinoma_Homo sapiens_hsa052110.81074413
78Epstein-Barr virus infection_Homo sapiens_hsa051690.80982394
79RNA transport_Homo sapiens_hsa030130.80175418
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79897012
81Pertussis_Homo sapiens_hsa051330.77712204
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.76364553
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76096532
84B cell receptor signaling pathway_Homo sapiens_hsa046620.76064495
85ECM-receptor interaction_Homo sapiens_hsa045120.75809939
86Mismatch repair_Homo sapiens_hsa034300.73914706
87Amoebiasis_Homo sapiens_hsa051460.73786203
88Staphylococcus aureus infection_Homo sapiens_hsa051500.73776300
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73011529
90Bladder cancer_Homo sapiens_hsa052190.72281046
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.71105281
92Viral carcinogenesis_Homo sapiens_hsa052030.70950934
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70690021
94Nucleotide excision repair_Homo sapiens_hsa034200.70409410
95Insulin resistance_Homo sapiens_hsa049310.69759742
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69507511
97Viral myocarditis_Homo sapiens_hsa054160.69320477
98Notch signaling pathway_Homo sapiens_hsa043300.68900808
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67821019
100Chemokine signaling pathway_Homo sapiens_hsa040620.67710018
101Endometrial cancer_Homo sapiens_hsa052130.67067703
102African trypanosomiasis_Homo sapiens_hsa051430.66731875
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66554610
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65078706
105Sphingolipid metabolism_Homo sapiens_hsa006000.64174659
106Other glycan degradation_Homo sapiens_hsa005110.63121644
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62905064
108Hepatitis C_Homo sapiens_hsa051600.62676388
109Type I diabetes mellitus_Homo sapiens_hsa049400.61850211
110VEGF signaling pathway_Homo sapiens_hsa043700.61511068
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61482933
112Phagosome_Homo sapiens_hsa041450.61473185
113Pathways in cancer_Homo sapiens_hsa052000.60216813
114Acute myeloid leukemia_Homo sapiens_hsa052210.59921308
115Platelet activation_Homo sapiens_hsa046110.59878067
116Thyroid cancer_Homo sapiens_hsa052160.59426768
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58700397
118Type II diabetes mellitus_Homo sapiens_hsa049300.58052047
119HIF-1 signaling pathway_Homo sapiens_hsa040660.57888489
120Glioma_Homo sapiens_hsa052140.57853737
121Proteoglycans in cancer_Homo sapiens_hsa052050.57839662
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57782716
123T cell receptor signaling pathway_Homo sapiens_hsa046600.57165162
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56399041
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56032154
126Melanoma_Homo sapiens_hsa052180.54417560
127MAPK signaling pathway_Homo sapiens_hsa040100.53035088

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