TINF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.33425226
2negative regulation of cell killing (GO:0031342)5.27435468
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.27435468
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.95068285
5mitotic metaphase plate congression (GO:0007080)4.88621916
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.86794265
7antigen processing and presentation of endogenous antigen (GO:0019883)4.77335943
8protein localization to kinetochore (GO:0034501)4.52091553
9DNA strand elongation involved in DNA replication (GO:0006271)4.45706865
10DNA replication initiation (GO:0006270)4.45625281
11DNA replication checkpoint (GO:0000076)4.37095191
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.31435976
13DNA unwinding involved in DNA replication (GO:0006268)4.29101182
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.25864123
15protein localization to chromosome, centromeric region (GO:0071459)4.24041300
16metaphase plate congression (GO:0051310)4.22282920
17DNA strand elongation (GO:0022616)4.22017446
18mitotic chromosome condensation (GO:0007076)4.19041633
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.15251809
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.15251809
21modulation by symbiont of host immune response (GO:0052553)4.15251809
22positive regulation by symbiont of host defense response (GO:0052509)4.15251809
23modulation by symbiont of host defense response (GO:0052031)4.15251809
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.15251809
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.09542057
26type I interferon signaling pathway (GO:0060337)4.08728345
27cellular response to type I interferon (GO:0071357)4.08728345
28mitotic nuclear envelope disassembly (GO:0007077)4.06547008
29response to type I interferon (GO:0034340)4.02430572
30telomere maintenance via semi-conservative replication (GO:0032201)4.02247161
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.00292289
32detection of other organism (GO:0098543)3.99549843
33regulation of spindle organization (GO:0090224)3.99475562
34negative regulation of interleukin-12 production (GO:0032695)3.97896904
35regulation of B cell receptor signaling pathway (GO:0050855)3.95380604
36CENP-A containing nucleosome assembly (GO:0034080)3.95019876
37detection of bacterium (GO:0016045)3.89885227
38immunoglobulin mediated immune response (GO:0016064)3.89427925
39leukocyte aggregation (GO:0070486)3.88589568
40chromatin remodeling at centromere (GO:0031055)3.88260732
41neutrophil activation involved in immune response (GO:0002283)3.85922059
42establishment of chromosome localization (GO:0051303)3.84761113
43mitotic sister chromatid segregation (GO:0000070)3.82027163
44regulation of gamma-delta T cell activation (GO:0046643)3.80541613
45macrophage activation involved in immune response (GO:0002281)3.80508184
46attachment of spindle microtubules to kinetochore (GO:0008608)3.79623150
47nucleobase biosynthetic process (GO:0046112)3.79099595
48membrane disassembly (GO:0030397)3.77784042
49nuclear envelope disassembly (GO:0051081)3.77784042
50DNA replication-dependent nucleosome organization (GO:0034723)3.77749894
51DNA replication-dependent nucleosome assembly (GO:0006335)3.77749894
52purine nucleobase biosynthetic process (GO:0009113)3.75828199
53regulation of interferon-beta biosynthetic process (GO:0045357)3.75226235
54DNA replication-independent nucleosome organization (GO:0034724)3.74086519
55DNA replication-independent nucleosome assembly (GO:0006336)3.74086519
56telomere maintenance via recombination (GO:0000722)3.68724807
57ribosome assembly (GO:0042255)3.65795093
58folic acid-containing compound biosynthetic process (GO:0009396)3.60888379
59mitotic recombination (GO:0006312)3.60816835
60negative T cell selection (GO:0043383)3.59385109
61negative thymic T cell selection (GO:0045060)3.58475794
62kinetochore organization (GO:0051383)3.55378710
63regulation of dendritic cell antigen processing and presentation (GO:0002604)3.53099908
64nuclear pore organization (GO:0006999)3.50117148
65sister chromatid segregation (GO:0000819)3.47730390
66histone exchange (GO:0043486)3.45126172
67defense response to protozoan (GO:0042832)3.42653553
68positive regulation of chromosome segregation (GO:0051984)3.42010120
69interferon-gamma-mediated signaling pathway (GO:0060333)3.41847205
70regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.41366251
71regulation of natural killer cell mediated immunity (GO:0002715)3.41366251
72response to peptidoglycan (GO:0032494)3.40423676
73regulation of gamma-delta T cell differentiation (GO:0045586)3.40182059
74regulation of mitotic spindle organization (GO:0060236)3.38534793
75kinetochore assembly (GO:0051382)3.35997215
76regulation of chromosome segregation (GO:0051983)3.35869961
77positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.35717926
78protein K6-linked ubiquitination (GO:0085020)3.30035636
79formation of translation preinitiation complex (GO:0001731)3.29740047
80maturation of SSU-rRNA (GO:0030490)3.28835389
81negative regulation of T cell mediated immunity (GO:0002710)3.27768567
82regulation of T cell mediated cytotoxicity (GO:0001914)3.27527626
83detection of external biotic stimulus (GO:0098581)3.27143884
84negative regulation of lymphocyte mediated immunity (GO:0002707)3.26706900
85* telomere maintenance via telomere lengthening (GO:0010833)3.24787695
86positive regulation of T cell mediated cytotoxicity (GO:0001916)3.24713051
87regulation of antigen processing and presentation (GO:0002577)3.24322023
88nuclear pore complex assembly (GO:0051292)3.23981309
89spindle checkpoint (GO:0031577)3.22896438
90ribosome biogenesis (GO:0042254)3.22717955
91negative regulation of chromosome segregation (GO:0051985)3.22665100
92DNA deamination (GO:0045006)3.21972320
93response to protozoan (GO:0001562)3.21124962
94negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19106127
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19106127
96negative regulation of sister chromatid segregation (GO:0033046)3.19106127
97negative regulation of mitotic sister chromatid separation (GO:2000816)3.19106127
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18135348
99* protein localization to chromosome (GO:0034502)3.16701515
100positive regulation of B cell differentiation (GO:0045579)3.16388059
101T cell migration (GO:0072678)3.15643105
102folic acid metabolic process (GO:0046655)3.15335083
103nucleotide-excision repair, DNA gap filling (GO:0006297)3.15274304
104cellular response to interleukin-15 (GO:0071350)3.15019776
105neutrophil activation (GO:0042119)3.11805289
106respiratory burst (GO:0045730)3.10603593
107response to interleukin-15 (GO:0070672)3.09826810
108mitotic spindle assembly checkpoint (GO:0007094)3.09154749
109T cell selection (GO:0045058)3.08911521
110spindle assembly checkpoint (GO:0071173)3.08250403
111granulocyte activation (GO:0036230)3.07879424
112chromosome segregation (GO:0007059)3.07634574
113nuclear envelope organization (GO:0006998)3.07423402
114positive thymic T cell selection (GO:0045059)3.06971181
115positive regulation of antigen processing and presentation (GO:0002579)3.06091752
116regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05721265
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05275319
118regulation of sister chromatid cohesion (GO:0007063)3.05202097
119chromatin assembly or disassembly (GO:0006333)3.04995192
120meiotic chromosome segregation (GO:0045132)3.04442684
121regulation of T cell tolerance induction (GO:0002664)3.02833594
122mitotic spindle checkpoint (GO:0071174)3.02434400
123B cell receptor signaling pathway (GO:0050853)3.02309954
124Arp2/3 complex-mediated actin nucleation (GO:0034314)3.00202119
125regulation of interferon-alpha production (GO:0032647)2.99537012
126IMP biosynthetic process (GO:0006188)2.99505198
127regulation of centrosome cycle (GO:0046605)2.98959998
128B cell mediated immunity (GO:0019724)2.98524773
129regulation of alpha-beta T cell proliferation (GO:0046640)2.98357750
130regulation of leukocyte mediated cytotoxicity (GO:0001910)2.96820949
131negative regulation of leukocyte mediated immunity (GO:0002704)2.96324806
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94999144
133ribonucleoprotein complex biogenesis (GO:0022613)2.93633210
134NIK/NF-kappaB signaling (GO:0038061)2.92618511
135detection of molecule of bacterial origin (GO:0032490)2.91401862
136thymic T cell selection (GO:0045061)2.90610452
137negative regulation of innate immune response (GO:0045824)2.90553787
138regulation of B cell differentiation (GO:0045577)2.90543530
139regulation of double-strand break repair via homologous recombination (GO:0010569)2.89347723
140regulation of sister chromatid segregation (GO:0033045)2.88703253
141regulation of mitotic sister chromatid separation (GO:0010965)2.88703253
142regulation of mitotic sister chromatid segregation (GO:0033047)2.88703253
143ATP-dependent chromatin remodeling (GO:0043044)2.87752543
144response to muramyl dipeptide (GO:0032495)2.87334851
145DNA duplex unwinding (GO:0032508)2.86374392
146response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86162953
147response to host immune response (GO:0052572)2.86162953
148DNA geometric change (GO:0032392)2.86057324
149ribosomal large subunit biogenesis (GO:0042273)2.85609709
150positive regulation of interferon-alpha production (GO:0032727)2.84816044
151transcription-coupled nucleotide-excision repair (GO:0006283)2.84056375
152detection of biotic stimulus (GO:0009595)2.83699186
153somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83367114
154somatic hypermutation of immunoglobulin genes (GO:0016446)2.83367114
155myeloid cell activation involved in immune response (GO:0002275)2.82833583
156ribosomal small subunit assembly (GO:0000028)2.82748875
157chromosome condensation (GO:0030261)2.82431199
158spliceosomal snRNP assembly (GO:0000387)2.79986997
159positive T cell selection (GO:0043368)2.78609028
160mismatch repair (GO:0006298)2.78362004
161rRNA processing (GO:0006364)2.78228092
162regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77797466
163cellular extravasation (GO:0045123)2.77579336
164positive regulation of type 2 immune response (GO:0002830)2.77562533
165regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77223450
166positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.77124523
167positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.77124523
168positive regulation of mitotic sister chromatid separation (GO:1901970)2.77124523
169mitotic cell cycle (GO:0000278)2.75983577
170regulation of cell killing (GO:0031341)2.75804594
171lipopolysaccharide-mediated signaling pathway (GO:0031663)2.75786498
172postreplication repair (GO:0006301)2.75362194
173regulation of mast cell degranulation (GO:0043304)2.73731581
174interferon-gamma production (GO:0032609)2.73347640
175histone H2A monoubiquitination (GO:0035518)2.72784097
176germinal center formation (GO:0002467)2.72677143
177maturation of 5.8S rRNA (GO:0000460)2.72066885
178positive regulation of defense response to virus by host (GO:0002230)2.72037895
179positive regulation of NF-kappaB import into nucleus (GO:0042346)2.71478532
180maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71348527
181* telomere organization (GO:0032200)2.71311184
182IMP metabolic process (GO:0046040)2.71188540
183cell cycle G1/S phase transition (GO:0044843)2.71028086
184G1/S transition of mitotic cell cycle (GO:0000082)2.71028086
185negative regulation of interleukin-6 production (GO:0032715)2.70688832
186tolerance induction (GO:0002507)2.70616117
187negative regulation of cytokine production involved in immune response (GO:0002719)2.67473650
188regulation of regulatory T cell differentiation (GO:0045589)2.66977722
189positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66846871
190response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66015239
191response to host (GO:0075136)2.66015239
192response to host defenses (GO:0052200)2.66015239
193positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.65559185
194response to interferon-beta (GO:0035456)2.64851471
195regulation of isotype switching to IgG isotypes (GO:0048302)2.64398950
196antigen receptor-mediated signaling pathway (GO:0050851)2.62854989
197myeloid dendritic cell differentiation (GO:0043011)2.61610363
198regulation of type 2 immune response (GO:0002828)2.60786912
199T-helper 1 type immune response (GO:0042088)2.60712519
200positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.60608285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.47723999
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.08060255
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.83492159
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.52720840
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.03785001
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.02492313
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.76138793
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63085533
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.42186598
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.31822977
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.27731521
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.23402144
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.88419650
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.88072888
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73600995
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73422329
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67755102
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.65438927
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56216660
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53437455
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.52549663
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50223642
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.49563060
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49047459
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.42584500
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.42579398
27RUNX_20019798_ChIP-Seq_JUKART_Human2.40712785
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38645988
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38325968
30AR_21909140_ChIP-Seq_LNCAP_Human2.38234960
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29615732
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.27160340
33XRN2_22483619_ChIP-Seq_HELA_Human2.22902762
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.21362170
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18057066
36VDR_24763502_ChIP-Seq_THP-1_Human2.16779001
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14851516
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08090615
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.06237758
40* VDR_23849224_ChIP-Seq_CD4+_Human2.04230902
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.00739624
42MYC_22102868_ChIP-Seq_BL_Human2.00116064
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99479582
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98563540
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95217467
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.92645745
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89659113
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.89207412
49* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88673318
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.87554019
51MAF_26560356_Chip-Seq_TH2_Human1.86270378
52SPI1_23127762_ChIP-Seq_K562_Human1.85475947
53FOXP3_21729870_ChIP-Seq_TREG_Human1.85006242
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84018552
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83620654
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83376616
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.81781081
58* DCP1A_22483619_ChIP-Seq_HELA_Human1.80646960
59CIITA_25753668_ChIP-Seq_RAJI_Human1.79567936
60* GABP_19822575_ChIP-Seq_HepG2_Human1.79282146
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78555800
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69145152
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66333073
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64795598
65SCL_19346495_ChIP-Seq_HPC-7_Human1.60403961
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60113659
67TTF2_22483619_ChIP-Seq_HELA_Human1.59341605
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58312423
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57663064
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55986201
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.55321119
72* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54747182
73GATA3_27048872_Chip-Seq_THYMUS_Human1.53650901
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50959387
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50152882
76KDM5A_27292631_Chip-Seq_BREAST_Human1.49157307
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48053755
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45963101
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45059806
80TCF7_22412390_ChIP-Seq_EML_Mouse1.41919823
81BCL6_27268052_Chip-Seq_Bcells_Human1.41195349
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39266413
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38008266
84* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37175936
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.36025194
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35303156
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34870930
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.34322020
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34114116
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33850750
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33479065
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.33478450
93KDM2B_26808549_Chip-Seq_DND41_Human1.33093743
94* LXR_22292898_ChIP-Seq_THP-1_Human1.33014082
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32770806
96VDR_24787735_ChIP-Seq_THP-1_Human1.32514431
97BCOR_27268052_Chip-Seq_Bcells_Human1.31736989
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31727436
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31636851
100HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31538481
101GATA3_26560356_Chip-Seq_TH2_Human1.31183292
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29731956
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28990414
104GATA1_22025678_ChIP-Seq_K562_Human1.27770374
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25632741
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24412150
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23860887
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23546419
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23419173
110IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23291547
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.21705256
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.21000698
113ELK1_19687146_ChIP-ChIP_HELA_Human1.21000140
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20963782
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20910168
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20705330
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20469194
118* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18774285
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18571305
120* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17355266
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16427690
122TFEB_21752829_ChIP-Seq_HELA_Human1.15498609
123SRF_21415370_ChIP-Seq_HL-1_Mouse1.14630738
124FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13980025
125KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13371879
126PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12843670
127GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12646622
128VDR_21846776_ChIP-Seq_THP-1_Human1.12035082
129ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11896548
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10333001
131CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10257999
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09880412
133GATA2_21666600_ChIP-Seq_HMVEC_Human1.09384670
134* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09270011
135STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08526467
136TP63_17297297_ChIP-ChIP_HaCaT_Human1.07827373
137SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07465022
138SMAD_19615063_ChIP-ChIP_OVARY_Human1.05668384
139* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02940558
140PU_27001747_Chip-Seq_BMDM_Mouse1.02789899
141NOTCH1_21737748_ChIP-Seq_TLL_Human0.98315106
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98266707
143CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98249785
144VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97877273
145FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97843515
146P68_20966046_ChIP-Seq_HELA_Human0.97428843
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97360966
148GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97046670
149KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95600015
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94830476
151CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94635340
152NANOG_21062744_ChIP-ChIP_HESCs_Human0.94615252
153TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94352614
154* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94240457
155KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93749252
156NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93573726
157MYC_18940864_ChIP-ChIP_HL60_Human0.93458766
158SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.93014076
159NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89220834
160GATA1_19941826_ChIP-Seq_K562_Human0.89073851
161SALL1_21062744_ChIP-ChIP_HESCs_Human0.88446525
162SPI1_23547873_ChIP-Seq_NB4_Human0.88271787
163CTCF_26484167_Chip-Seq_Bcells_Mouse0.88064472
164GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84836854
165PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84769452
166ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84306363
167YY1_22570637_ChIP-Seq_MALME-3M_Human0.84243891
168TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83973091
169CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83214239
170NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83208568
171TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82615726
172UTX_26944678_Chip-Seq_JUKART_Human0.81622922
173STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81023918
174E2F1_20622854_ChIP-Seq_HELA_Human0.80718474
175IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.77391902
176MYB_26560356_Chip-Seq_TH2_Human0.75945348
177MAF_26560356_Chip-Seq_TH1_Human0.75852633
178MYB_26560356_Chip-Seq_TH1_Human0.74653955
179* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74260187
180SOX2_18692474_ChIP-Seq_MEFs_Mouse0.72478042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.52222461
2MP0010094_abnormal_chromosome_stability4.51652367
3MP0003111_abnormal_nucleus_morphology4.44362452
4MP0003724_increased_susceptibility_to4.16987733
5MP0003436_decreased_susceptibility_to4.16958358
6MP0004957_abnormal_blastocyst_morpholog4.12164671
7MP0003077_abnormal_cell_cycle3.99130980
8MP0003303_peritoneal_inflammation3.89332409
9MP0006082_CNS_inflammation3.36364248
10MP0008057_abnormal_DNA_replication3.32904065
11MP0009785_altered_susceptibility_to3.30519416
12MP0005000_abnormal_immune_tolerance3.05435209
13MP0005387_immune_system_phenotype3.04146514
14MP0001790_abnormal_immune_system3.04146514
15MP0008058_abnormal_DNA_repair3.01284374
16MP0005025_abnormal_response_to2.88653578
17MP0002148_abnormal_hypersensitivity_rea2.70686705
18MP0002419_abnormal_innate_immunity2.69268158
19MP0008007_abnormal_cellular_replicative2.67239916
20MP0003300_gastrointestinal_ulcer2.51778006
21MP0010352_gastrointestinal_tract_polyps2.42389442
22MP0001730_embryonic_growth_arrest2.39963432
23MP0008932_abnormal_embryonic_tissue2.35769394
24MP0008877_abnormal_DNA_methylation2.19317733
25MP0000350_abnormal_cell_proliferation2.15117154
26MP0001533_abnormal_skeleton_physiology2.11913690
27MP0003718_maternal_effect2.01793684
28MP0005058_abnormal_lysosome_morphology1.96284551
29MP0002396_abnormal_hematopoietic_system1.94419165
30MP0009764_decreased_sensitivity_to1.89847658
31MP0005464_abnormal_platelet_physiology1.84394175
32MP0001845_abnormal_inflammatory_respons1.83372381
33MP0003191_abnormal_cellular_cholesterol1.83217301
34MP0003763_abnormal_thymus_physiology1.80314960
35MP0010307_abnormal_tumor_latency1.78067907
36MP0003123_paternal_imprinting1.77842671
37MP0003172_abnormal_lysosome_physiology1.75831857
38MP0001672_abnormal_embryogenesis/_devel1.73083472
39MP0005380_embryogenesis_phenotype1.73083472
40MP0000490_abnormal_crypts_of1.71589028
41MP0001697_abnormal_embryo_size1.67167102
42MP0003786_premature_aging1.67129913
43MP0003806_abnormal_nucleotide_metabolis1.65689513
44MP0008469_abnormal_protein_level1.63600935
45MP0002019_abnormal_tumor_incidence1.55277630
46MP0009333_abnormal_splenocyte_physiolog1.53809228
47MP0003984_embryonic_growth_retardation1.52741002
48* MP0002080_prenatal_lethality1.50565756
49MP0002088_abnormal_embryonic_growth/wei1.49392454
50MP0002085_abnormal_embryonic_tissue1.49099058
51MP0003075_altered_response_to1.45371176
52MP0000465_gastrointestinal_hemorrhage1.43461289
53MP0005451_abnormal_body_composition1.42747054
54MP0002210_abnormal_sex_determination1.37385923
55MP0003866_abnormal_defecation1.36996063
56MP0002084_abnormal_developmental_patter1.36723997
57MP0002398_abnormal_bone_marrow1.35524485
58MP0000703_abnormal_thymus_morphology1.34285137
59MP0001929_abnormal_gametogenesis1.34004756
60MP0000313_abnormal_cell_death1.32186277
61MP0002086_abnormal_extraembryonic_tissu1.31744516
62MP0000685_abnormal_immune_system1.31715222
63MP0005076_abnormal_cell_differentiation1.27639459
64MP0002653_abnormal_ependyma_morphology1.27163756
65MP0000689_abnormal_spleen_morphology1.25523253
66MP0001145_abnormal_male_reproductive1.23726067
67MP0002722_abnormal_immune_system1.23141537
68MP0004510_myositis1.20636243
69MP0000343_altered_response_to1.19262542
70MP0002933_joint_inflammation1.18177377
71MP0003315_abnormal_perineum_morphology1.18155714
72MP0000604_amyloidosis1.17958371
73MP0005166_decreased_susceptibility_to1.15633108
74MP0002998_abnormal_bone_remodeling1.15486194
75MP0004808_abnormal_hematopoietic_stem1.14962985
76MP0002138_abnormal_hepatobiliary_system1.13209272
77MP0004197_abnormal_fetal_growth/weight/1.13195168
78MP0000653_abnormal_sex_gland1.11494327
79MP0010030_abnormal_orbit_morphology1.11324162
80MP0001986_abnormal_taste_sensitivity1.10412156
81MP0001835_abnormal_antigen_presentation1.10096769
82MP0003448_altered_tumor_morphology1.08014383
83MP0005310_abnormal_salivary_gland1.07883101
84MP0004381_abnormal_hair_follicle1.06121050
85MP0001800_abnormal_humoral_immune1.04810915
86MP0002429_abnormal_blood_cell1.04500974
87MP0003183_abnormal_peptide_metabolism1.03786236
88MP0009763_increased_sensitivity_to1.02607353
89MP0001119_abnormal_female_reproductive1.01121533
90MP0005671_abnormal_response_to1.00289823
91MP0000716_abnormal_immune_system0.99332025
92MP0002160_abnormal_reproductive_system0.99110879
93MP0003890_abnormal_embryonic-extraembry0.99050656
94MP0004883_abnormal_blood_vessel0.98147830
95MP0009840_abnormal_foam_cell0.98021335
96MP0003690_abnormal_glial_cell0.97087270
97MP0000678_abnormal_parathyroid_gland0.97074431
98MP0001851_eye_inflammation0.96495521
99MP0002277_abnormal_respiratory_mucosa0.96302433
100MP0003567_abnormal_fetal_cardiomyocyte0.95932568
101MP0002166_altered_tumor_susceptibility0.95353288
102MP0006292_abnormal_olfactory_placode0.95294001
103MP0005397_hematopoietic_system_phenotyp0.95105812
104MP0001545_abnormal_hematopoietic_system0.95105812
105MP0009672_abnormal_birth_weight0.94698715
106MP0001293_anophthalmia0.94115949
107MP0001663_abnormal_digestive_system0.93516532
108MP0005390_skeleton_phenotype0.93427936
109MP0000015_abnormal_ear_pigmentation0.92989159
110MP0003828_pulmonary_edema0.91784197
111MP0003121_genomic_imprinting0.88504875
112MP0009765_abnormal_xenobiotic_induced0.86766155
113MP0001853_heart_inflammation0.85203299
114MP0005167_abnormal_blood-brain_barrier0.85031588
115MP0002254_reproductive_system_inflammat0.84650688
116MP0003195_calcinosis0.84211737
117MP0003656_abnormal_erythrocyte_physiolo0.84129440
118MP0009053_abnormal_anal_canal0.82756386
119MP0002332_abnormal_exercise_endurance0.82526078
120MP0001819_abnormal_immune_cell0.82344973
121MP0002405_respiratory_system_inflammati0.82339487
122MP0002420_abnormal_adaptive_immunity0.81955755
123MP0003119_abnormal_digestive_system0.81904518
124MP0005389_reproductive_system_phenotype0.81865741
125MP0002452_abnormal_antigen_presenting0.81442365
126MP0000858_altered_metastatic_potential0.81196920
127MP0003699_abnormal_female_reproductive0.79236238
128MP0005075_abnormal_melanosome_morpholog0.79115894
129MP0005621_abnormal_cell_physiology0.79076607
130MP0001873_stomach_inflammation0.78977583
131MP0003221_abnormal_cardiomyocyte_apopto0.77346465
132MP0008004_abnormal_stomach_pH0.76783882
133MP0005023_abnormal_wound_healing0.75618539
134MP0005164_abnormal_response_to0.74870903
135MP0005384_cellular_phenotype0.74813099
136MP0000477_abnormal_intestine_morphology0.73961965
137MP0002723_abnormal_immune_serum0.73961916
138MP0000358_abnormal_cell_content/0.73127637
139MP0002132_abnormal_respiratory_system0.70469144
140MP0003937_abnormal_limbs/digits/tail_de0.70290000
141MP0002006_tumorigenesis0.69831768
142MP0002102_abnormal_ear_morphology0.66707373
143MP0003795_abnormal_bone_structure0.66165293
144MP0004264_abnormal_extraembryonic_tissu0.65126895
145MP0002111_abnormal_tail_morphology0.64901956
146MP0002161_abnormal_fertility/fecundity0.64470314
147MP0009278_abnormal_bone_marrow0.64221769
148MP0001542_abnormal_bone_strength0.63893634
149MP0000249_abnormal_blood_vessel0.63680565
150MP0004947_skin_inflammation0.63626298
151MP0008995_early_reproductive_senescence0.63210637
152MP0001849_ear_inflammation0.62433143
153MP0005084_abnormal_gallbladder_morpholo0.62388599
154MP0005395_other_phenotype0.62343887
155MP0008874_decreased_physiological_sensi0.62145829
156MP0000920_abnormal_myelination0.61011593
157MP0003698_abnormal_male_reproductive0.59950601
158MP0008260_abnormal_autophagy0.59892182
159MP0004133_heterotaxia0.59833322
160MP0005319_abnormal_enzyme/_coenzyme0.59408379
161MP0001915_intracranial_hemorrhage0.57628471
162MP0010155_abnormal_intestine_physiology0.57226542
163MP0001919_abnormal_reproductive_system0.56947665
164MP0006054_spinal_hemorrhage0.55885079
165MP0003453_abnormal_keratinocyte_physiol0.55273467
166MP0004147_increased_porphyrin_level0.55127577
167MP0000609_abnormal_liver_physiology0.54787319
168MP0005381_digestive/alimentary_phenotyp0.53613183
169MP0001958_emphysema0.49934947

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.67101788
2Birth length less than 3rd percentile (HP:0003561)5.37086879
3Myositis (HP:0100614)5.19759452
4Abnormality of macrophages (HP:0004311)5.10786262
5Orchitis (HP:0100796)5.04764269
6Recurrent bacterial skin infections (HP:0005406)4.98834671
7Retrobulbar optic neuritis (HP:0100654)4.98240884
8Optic neuritis (HP:0100653)4.98240884
9Elevated erythrocyte sedimentation rate (HP:0003565)4.87288370
10Stomatitis (HP:0010280)4.76340834
11Recurrent abscess formation (HP:0002722)4.72773860
12Breast hypoplasia (HP:0003187)4.27415346
13Increased IgM level (HP:0003496)3.80948920
14Mediastinal lymphadenopathy (HP:0100721)3.80205950
15Chromsome breakage (HP:0040012)3.76533423
16Carpal bone hypoplasia (HP:0001498)3.75432520
17Keratoconjunctivitis (HP:0001096)3.74430138
18Keratoconjunctivitis sicca (HP:0001097)3.73628557
19Recurrent fungal infections (HP:0002841)3.73242484
20Patellar aplasia (HP:0006443)3.70424888
21Recurrent gram-negative bacterial infections (HP:0005420)3.69279236
22Abnormality of T cell number (HP:0011839)3.67277505
23Abnormality of glycolipid metabolism (HP:0010969)3.57932363
24Abnormality of liposaccharide metabolism (HP:0010968)3.57932363
25Abnormality of glycosphingolipid metabolism (HP:0004343)3.57932363
26Vasculitis (HP:0002633)3.54803997
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.53795510
28Gastrointestinal infarctions (HP:0005244)3.50386909
29Autoimmune thrombocytopenia (HP:0001973)3.48957700
30Encephalitis (HP:0002383)3.48886594
31Vacuolated lymphocytes (HP:0001922)3.47462189
32Meningitis (HP:0001287)3.47446876
33Aplasia/Hypoplasia of the patella (HP:0006498)3.46340268
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.39733242
35Recurrent skin infections (HP:0001581)3.38935429
36Reticulocytopenia (HP:0001896)3.36485918
37Abnormality of chromosome stability (HP:0003220)3.27920315
38Selective tooth agenesis (HP:0001592)3.24597711
39Recurrent cutaneous fungal infections (HP:0011370)3.19975252
40Chronic mucocutaneous candidiasis (HP:0002728)3.19975252
41Increased IgE level (HP:0003212)3.14356843
42Meckel diverticulum (HP:0002245)3.10931431
43Abnormality of the preputium (HP:0100587)3.03814970
44Autoimmune hemolytic anemia (HP:0001890)2.99995775
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.99327562
46Colon cancer (HP:0003003)2.98379728
47Pulmonary infiltrates (HP:0002113)2.96784679
48Abnormality of the ileum (HP:0001549)2.95942431
49Urticaria (HP:0001025)2.94036628
50Leukocytosis (HP:0001974)2.93367701
51Obstructive lung disease (HP:0006536)2.92249294
52Chronic obstructive pulmonary disease (HP:0006510)2.92249294
53Medulloblastoma (HP:0002885)2.90790734
54Granulocytopenia (HP:0001913)2.89953082
55Abnormality of the labia minora (HP:0012880)2.85467674
56Facial hemangioma (HP:0000329)2.85246890
57Absent radius (HP:0003974)2.84406718
58Degeneration of anterior horn cells (HP:0002398)2.83602526
59Abnormality of the anterior horn cell (HP:0006802)2.83602526
60Eosinophilia (HP:0001880)2.83143731
61Loss of speech (HP:0002371)2.82779887
62Hypergammaglobulinemia (HP:0010702)2.81972314
63Systemic lupus erythematosus (HP:0002725)2.81318311
64Ependymoma (HP:0002888)2.81215987
65Recurrent viral infections (HP:0004429)2.80318042
66Hemoptysis (HP:0002105)2.79896158
67Abnormality of eosinophils (HP:0001879)2.78040684
68Absent thumb (HP:0009777)2.76744829
69Impulsivity (HP:0100710)2.74891655
70Increased serum ferritin (HP:0003281)2.73469337
71Small intestinal stenosis (HP:0012848)2.72040152
72Duodenal stenosis (HP:0100867)2.72040152
73Microretrognathia (HP:0000308)2.67574959
74Lymphopenia (HP:0001888)2.66782099
75Premature ovarian failure (HP:0008209)2.66323608
76Gangrene (HP:0100758)2.65489467
77Episodic fever (HP:0001954)2.64541153
78Pustule (HP:0200039)2.63408872
79Petechiae (HP:0000967)2.63245393
80Aplasia involving forearm bones (HP:0009822)2.61428735
81Absent forearm bone (HP:0003953)2.61428735
82Dysostosis multiplex (HP:0000943)2.61030613
83Ectopic kidney (HP:0000086)2.59946941
84Abnormality of cells of the lymphoid lineage (HP:0012140)2.56789807
85Purpura (HP:0000979)2.55541947
86Abnormality of B cell number (HP:0010975)2.55215679
87Myelodysplasia (HP:0002863)2.54707857
88Cerebral hypomyelination (HP:0006808)2.54467438
89Abnormality of cells of the erythroid lineage (HP:0012130)2.52908647
90Secondary amenorrhea (HP:0000869)2.50723777
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.45883856
92Overlapping toe (HP:0001845)2.45680307
93Gingivitis (HP:0000230)2.41795077
94Cellulitis (HP:0100658)2.40701699
95Abnormal number of incisors (HP:0011064)2.36794537
96Abnormal spermatogenesis (HP:0008669)2.36052600
97Sloping forehead (HP:0000340)2.35622402
98Increased cerebral lipofuscin (HP:0011813)2.34827233
99Rhabdomyosarcoma (HP:0002859)2.34374596
100Joint swelling (HP:0001386)2.32695702
101Prolonged bleeding time (HP:0003010)2.32591061
102Anorexia (HP:0002039)2.32178727
103Abnormality of the duodenum (HP:0002246)2.30620030
104Horseshoe kidney (HP:0000085)2.29337587
105Multiple enchondromatosis (HP:0005701)2.29082944
106Combined immunodeficiency (HP:0005387)2.28255584
107Abnormal number of erythroid precursors (HP:0012131)2.28254204
108Agammaglobulinemia (HP:0004432)2.28210631
109Tetany (HP:0001281)2.26770573
110Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26618074
111Keratitis (HP:0000491)2.26499000
112Abnormal lung lobation (HP:0002101)2.26112493
113Abnormality of iron homeostasis (HP:0011031)2.25466482
114Hypochromic anemia (HP:0001931)2.25124495
115Basal cell carcinoma (HP:0002671)2.24766187
116Inflammation of the large intestine (HP:0002037)2.24512221
117* Rough bone trabeculation (HP:0100670)2.24459875
118Stomach cancer (HP:0012126)2.24057462
119Panhypogammaglobulinemia (HP:0003139)2.22449969
120Spontaneous hematomas (HP:0007420)2.21491296
121* Cellular immunodeficiency (HP:0005374)2.20196759
122Supernumerary spleens (HP:0009799)2.19890263
123Gastrointestinal inflammation (HP:0004386)2.19887405
124IgM deficiency (HP:0002850)2.19528894
125Short thumb (HP:0009778)2.18809949
126Prominent nose (HP:0000448)2.18451175
127* Bone marrow hypocellularity (HP:0005528)2.18231512
128* Neoplasm of the pancreas (HP:0002894)2.17955408
129Pulmonary embolism (HP:0002204)2.16150603
130IgG deficiency (HP:0004315)2.14803959
131Recurrent bronchitis (HP:0002837)2.14319640
132Glomerulopathy (HP:0100820)2.14008961
133Epistaxis (HP:0000421)2.13813998
134Cafe-au-lait spot (HP:0000957)2.13531524
135Squamous cell carcinoma (HP:0002860)2.13468775
136Chest pain (HP:0100749)2.13233588
137Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.13209338
138Triphalangeal thumb (HP:0001199)2.12266190
139Prostate neoplasm (HP:0100787)2.11902551
140Abnormality of the pleura (HP:0002103)2.11606318
141Arterial thrombosis (HP:0004420)2.11331465
142Agnosia (HP:0010524)2.09910225
143Gastrointestinal stroma tumor (HP:0100723)2.09602977
144Sepsis (HP:0100806)2.07538979
145* Lymphoma (HP:0002665)2.04681736
146Aplasia/Hypoplasia of the sternum (HP:0006714)2.03578929
147Gingival bleeding (HP:0000225)2.02994224
148Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02435027
149Abnormality of polysaccharide metabolism (HP:0011012)2.02435027
150Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02435027
151* Tracheoesophageal fistula (HP:0002575)2.02082932
152Abnormality of the prostate (HP:0008775)1.99893771
153Proximal placement of thumb (HP:0009623)1.99485730
154Nasal polyposis (HP:0100582)1.99270847
155Cleft eyelid (HP:0000625)1.98946812
156Abnormality of the carotid arteries (HP:0005344)1.98185494
157Breast aplasia (HP:0100783)1.97317150
158Trismus (HP:0000211)1.97282337
159* Oral leukoplakia (HP:0002745)1.96649519
160Atresia of the external auditory canal (HP:0000413)1.96442670
161Arthralgia (HP:0002829)1.96268777
162Increased nuchal translucency (HP:0010880)1.94499170
163Abnormality of pyrimidine metabolism (HP:0004353)1.94474983
164Amyloidosis (HP:0011034)1.94150099
165Hematochezia (HP:0002573)1.94040557
166Oligodactyly (HP:0012165)1.93241234
167Macrocytic anemia (HP:0001972)1.93131167
168Deviation of the thumb (HP:0009603)1.92671427
169Abnormality of T cells (HP:0002843)1.91699936
170Abnormality of transition element cation homeostasis (HP:0011030)1.90764873
171Recurrent pneumonia (HP:0006532)1.88790177
172Abnormality of DNA repair (HP:0003254)1.88424503
173Severe combined immunodeficiency (HP:0004430)1.88319527
174Aplasia/Hypoplasia of the breasts (HP:0010311)1.87764443
175Amaurosis fugax (HP:0100576)1.87292798
176Ureteral duplication (HP:0000073)1.86786124
177Neoplasm of striated muscle (HP:0009728)1.86011079
178Duplicated collecting system (HP:0000081)1.85310188
179Pallor (HP:0000980)1.84966287
180Neoplasm of the colon (HP:0100273)1.84192208
181High pitched voice (HP:0001620)1.82587097
182Slender long bone (HP:0003100)1.82440229
183Abnormality of the fingertips (HP:0001211)1.81884577
184Clubbing of toes (HP:0100760)1.80316733
185Abnormality of T cell physiology (HP:0011840)1.77538662
18611 pairs of ribs (HP:0000878)1.77142907
187Atrophy/Degeneration involving motor neurons (HP:0007373)1.70759308
188Anal stenosis (HP:0002025)1.69473392
189Choanal atresia (HP:0000453)1.68938248
190Neoplasm of the oral cavity (HP:0100649)1.68338648
191T lymphocytopenia (HP:0005403)1.66444342
192Poikiloderma (HP:0001029)1.64393187
193Entropion (HP:0000621)1.63791047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.85758297
2CDC73.91437764
3WEE13.79716801
4TAOK33.64188259
5NEK23.37713102
6RIPK43.36160041
7TTK2.83809715
8EIF2AK12.61618429
9ERN12.51828292
10IKBKE2.45497379
11BLK2.41061168
12PLK42.37891807
13ACVR1B2.31573450
14TESK22.21024748
15MAP3K142.18765750
16IRAK42.17802748
17NEK12.02986514
18CSK2.00997338
19PLK11.99193627
20DYRK31.91877757
21TSSK61.90694510
22STK101.89457716
23PRPF4B1.88360650
24CDK121.84796768
25MAP4K11.80896076
26SRPK11.80359551
27SYK1.74310962
28AURKB1.72216903
29FES1.69544259
30MAP3K101.66535976
31BRSK21.64214412
32CDK41.63444566
33CHEK21.59496582
34MAP3K81.56909639
35EEF2K1.55970202
36MAP3K31.55651535
37CDK71.54739439
38ATR1.52519704
39RPS6KA41.51249393
40FGR1.50733971
41EIF2AK31.46317435
42JAK11.44858628
43EPHB11.42064270
44EPHA21.41635318
45RPS6KB21.41227680
46PASK1.37735699
47LCK1.35072350
48LYN1.33751962
49CCNB11.31802926
50TNK21.31477390
51PIM21.29544548
52GRK71.27891397
53SIK31.27589650
54HCK1.27519018
55MELK1.26436622
56AURKA1.26305476
57PLK31.24628268
58IRAK31.24203607
59NME21.23493973
60VRK11.23163472
61STK41.22523484
62CHEK11.22499458
63BRAF1.21363973
64BRSK11.20094083
65STK31.13879228
66MATK1.10685032
67MAP3K131.09264589
68JAK21.09143773
69BMPR21.06861400
70KIT1.05196254
71PAK41.04382987
72STK38L1.04087249
73BRD41.03236280
74STK161.03141817
75PIM10.98904757
76TLK10.93373214
77TGFBR20.85320863
78LATS10.83357638
79MAP3K10.82617451
80TYK20.81974535
81EPHA30.79064458
82ZAP700.77984510
83MAP4K20.76875339
84LATS20.76741972
85IRAK10.76238780
86ATM0.76061749
87CDK20.75706600
88MKNK10.75487590
89TESK10.73206267
90PRKD20.73133104
91GRK60.71149119
92RIPK10.70590023
93PAK10.70251464
94MAP3K110.69617102
95TGFBR10.68526744
96LRRK20.67127827
97RPS6KA50.66512140
98ADRBK20.65386997
99JAK30.65039534
100KDR0.63911698
101CDK60.63427268
102MAP2K60.63391625
103ZAK0.62545185
104DYRK20.62245367
105PRKCQ0.62164731
106IRAK20.61334765
107MAP2K30.60576763
108SIK20.59630196
109PRKCI0.59127248
110RAF10.58271873
111FYN0.57423542
112PDK10.57247930
113CDK10.55431889
114BCKDK0.54490286
115CDK90.54209478
116FGFR40.54189063
117DDR20.52733499
118TEC0.52574287
119PDPK10.51744375
120CDK80.51227659
121TBK10.50792898
122CDC42BPA0.50481243
123MAPKAPK30.49123248
124TAOK20.48583702
125DYRK1B0.47955512
126FGFR30.47603136
127KSR20.46140762
128MOS0.46030699
129ITK0.45405830
130ALK0.44646987
131CSNK2A10.43610192
132CAMKK20.43004584
133MAPK120.42518609
134ARAF0.42415603
135CHUK0.41618955
136FLT30.40929728
137CSNK2A20.40657706
138HIPK20.40570385
139MTOR0.39230888
140IKBKB0.39143120
141MARK20.38921008
142BTK0.38829284
143MKNK20.37683804
144CSF1R0.37460327
145MAPK70.37369796
146TAOK10.36547345
147NLK0.36314489
148EIF2AK20.36314343
149CLK10.35846292
150MAP3K70.35685753
151MAP3K50.35314819
152MARK30.34881280
153MAP2K40.32476234
154PKN20.32335434
155MAPKAPK20.31887358
156LIMK10.31497606
157TRIB30.31327303
158TXK0.30988513
159ABL10.29955520
160CAMKK10.29664625
161MAP3K60.29231494
162MAP2K20.28919589
163MAPK40.28153848
164DAPK20.27444757
165AKT20.27324218
166MAPK110.27223542
167INSR0.27211934
168PRKCD0.26305940
169PRKD10.26287574
170PRKCZ0.24755102

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.75411366
2Mismatch repair_Homo sapiens_hsa034303.87427361
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32450979
4RNA polymerase_Homo sapiens_hsa030203.13439280
5Base excision repair_Homo sapiens_hsa034103.12927634
6Spliceosome_Homo sapiens_hsa030403.12502999
7Homologous recombination_Homo sapiens_hsa034403.05982507
8Cell cycle_Homo sapiens_hsa041103.04772406
9RNA transport_Homo sapiens_hsa030133.03711587
10Graft-versus-host disease_Homo sapiens_hsa053322.96738224
11Autoimmune thyroid disease_Homo sapiens_hsa053202.80190338
12Staphylococcus aureus infection_Homo sapiens_hsa051502.70862202
13Leishmaniasis_Homo sapiens_hsa051402.69596359
14Proteasome_Homo sapiens_hsa030502.67958627
15Nucleotide excision repair_Homo sapiens_hsa034202.66698697
16Osteoclast differentiation_Homo sapiens_hsa043802.61326170
17One carbon pool by folate_Homo sapiens_hsa006702.49765220
18Ribosome_Homo sapiens_hsa030102.48953081
19Type I diabetes mellitus_Homo sapiens_hsa049402.38698478
20Pyrimidine metabolism_Homo sapiens_hsa002402.34070626
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27844829
22Fanconi anemia pathway_Homo sapiens_hsa034602.25913201
23Toll-like receptor signaling pathway_Homo sapiens_hsa046202.25024918
24Non-homologous end-joining_Homo sapiens_hsa034502.22735675
25Basal transcription factors_Homo sapiens_hsa030222.06299929
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.04462324
27Tuberculosis_Homo sapiens_hsa051522.04359726
28Other glycan degradation_Homo sapiens_hsa005111.94110682
29RNA degradation_Homo sapiens_hsa030181.93188391
30Rheumatoid arthritis_Homo sapiens_hsa053231.84729661
31p53 signaling pathway_Homo sapiens_hsa041151.80334270
32Malaria_Homo sapiens_hsa051441.75146369
33mRNA surveillance pathway_Homo sapiens_hsa030151.70839921
34TNF signaling pathway_Homo sapiens_hsa046681.62067671
35Pertussis_Homo sapiens_hsa051331.61901939
36Lysosome_Homo sapiens_hsa041421.49799115
37Phagosome_Homo sapiens_hsa041451.43746719
38Vitamin B6 metabolism_Homo sapiens_hsa007501.43482490
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.43267681
40Primary immunodeficiency_Homo sapiens_hsa053401.40023673
41Salmonella infection_Homo sapiens_hsa051321.34060974
42Chemokine signaling pathway_Homo sapiens_hsa040621.34047756
43Epstein-Barr virus infection_Homo sapiens_hsa051691.33478514
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32504204
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31029868
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.29440009
47Pentose phosphate pathway_Homo sapiens_hsa000301.20572637
48Purine metabolism_Homo sapiens_hsa002301.19712309
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18677986
50Antigen processing and presentation_Homo sapiens_hsa046121.18065276
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16867279
52Herpes simplex infection_Homo sapiens_hsa051681.14251386
53Systemic lupus erythematosus_Homo sapiens_hsa053221.11600402
54Selenocompound metabolism_Homo sapiens_hsa004501.08752022
55Hepatitis C_Homo sapiens_hsa051601.07392096
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07242714
57Oocyte meiosis_Homo sapiens_hsa041141.04744478
58Biosynthesis of amino acids_Homo sapiens_hsa012301.04382843
59African trypanosomiasis_Homo sapiens_hsa051431.03794902
60Viral carcinogenesis_Homo sapiens_hsa052031.02757780
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02302110
62Folate biosynthesis_Homo sapiens_hsa007900.99050082
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.97700453
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96499157
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94999188
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92295641
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91752062
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86909136
69HTLV-I infection_Homo sapiens_hsa051660.86794267
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.82624959
71Sulfur relay system_Homo sapiens_hsa041220.80163900
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.73297745
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.73240791
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70003546
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67858528
76Endocytosis_Homo sapiens_hsa041440.67546845
77Platelet activation_Homo sapiens_hsa046110.66733095
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64766728
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.64561728
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.63974731
81VEGF signaling pathway_Homo sapiens_hsa043700.63119504
82Small cell lung cancer_Homo sapiens_hsa052220.62944844
83Measles_Homo sapiens_hsa051620.62848482
84Apoptosis_Homo sapiens_hsa042100.59844645
85Collecting duct acid secretion_Homo sapiens_hsa049660.59781096
86MicroRNAs in cancer_Homo sapiens_hsa052060.58995144
87Legionellosis_Homo sapiens_hsa051340.58116556
88Prolactin signaling pathway_Homo sapiens_hsa049170.57438737
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57285650
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56889279
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56733196
92Hepatitis B_Homo sapiens_hsa051610.52151343
93Carbon metabolism_Homo sapiens_hsa012000.51986545
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.51432827
95Notch signaling pathway_Homo sapiens_hsa043300.50540620
96Shigellosis_Homo sapiens_hsa051310.50306434
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.48679818
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47771870
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45808910
100Colorectal cancer_Homo sapiens_hsa052100.45073624
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.44654888
102Non-small cell lung cancer_Homo sapiens_hsa052230.43489062
103Hippo signaling pathway_Homo sapiens_hsa043900.42562582
104T cell receptor signaling pathway_Homo sapiens_hsa046600.41885831
105TGF-beta signaling pathway_Homo sapiens_hsa043500.40341957
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39665107
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39332402
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39057977
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38202178
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37895422
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37576472
112Influenza A_Homo sapiens_hsa051640.37461163
113Glutathione metabolism_Homo sapiens_hsa004800.36676251
114Insulin resistance_Homo sapiens_hsa049310.36093842
115Pancreatic cancer_Homo sapiens_hsa052120.35599493
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35009359
117Hematopoietic cell lineage_Homo sapiens_hsa046400.34123639
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33888130
119Complement and coagulation cascades_Homo sapiens_hsa046100.33274153
120Basal cell carcinoma_Homo sapiens_hsa052170.32182007
121Fructose and mannose metabolism_Homo sapiens_hsa000510.32163682
122Thyroid cancer_Homo sapiens_hsa052160.31569089
123Vibrio cholerae infection_Homo sapiens_hsa051100.31045902
124Chronic myeloid leukemia_Homo sapiens_hsa052200.30744312
125mTOR signaling pathway_Homo sapiens_hsa041500.29943175
126B cell receptor signaling pathway_Homo sapiens_hsa046620.29587767
127Sphingolipid metabolism_Homo sapiens_hsa006000.28808747
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28759588
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28607803
130Viral myocarditis_Homo sapiens_hsa054160.28304970
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28117874
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27386272
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26925719
134MAPK signaling pathway_Homo sapiens_hsa040100.26053174
135Bladder cancer_Homo sapiens_hsa052190.24726844
136Acute myeloid leukemia_Homo sapiens_hsa052210.24625903
137FoxO signaling pathway_Homo sapiens_hsa040680.23002395
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22024478
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20690624
140Amoebiasis_Homo sapiens_hsa051460.20656567
141Ether lipid metabolism_Homo sapiens_hsa005650.20387929
142Asthma_Homo sapiens_hsa053100.20375739
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18966015
144Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18711974
145Regulation of autophagy_Homo sapiens_hsa041400.18540818
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18097454
147Pathways in cancer_Homo sapiens_hsa052000.17719937
148Galactose metabolism_Homo sapiens_hsa000520.16799160
149Allograft rejection_Homo sapiens_hsa053300.16489253
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16422706
151HIF-1 signaling pathway_Homo sapiens_hsa040660.14848840
152Lysine degradation_Homo sapiens_hsa003100.14494075
153Toxoplasmosis_Homo sapiens_hsa051450.14463607
154Alcoholism_Homo sapiens_hsa050340.14352122
155Hedgehog signaling pathway_Homo sapiens_hsa043400.14301168
156Metabolic pathways_Homo sapiens_hsa011000.13956654
157Adherens junction_Homo sapiens_hsa045200.13949290
158ABC transporters_Homo sapiens_hsa020100.13775186
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.13573659

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