TIMM8B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.66449233
2ATP synthesis coupled proton transport (GO:0015986)9.06203809
3energy coupled proton transport, down electrochemical gradient (GO:0015985)9.06203809
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.44373785
5respiratory electron transport chain (GO:0022904)7.49816220
6electron transport chain (GO:0022900)7.31901710
7ribosomal small subunit assembly (GO:0000028)6.44435677
8protein neddylation (GO:0045116)5.72451943
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.62979928
10maturation of SSU-rRNA (GO:0030490)5.56473157
11translational elongation (GO:0006414)5.54859766
12protein complex biogenesis (GO:0070271)5.10244587
13hydrogen ion transmembrane transport (GO:1902600)4.96235612
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.94751365
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.86729361
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.86729361
17NADH dehydrogenase complex assembly (GO:0010257)4.86729361
18translational initiation (GO:0006413)4.82460529
19ATP biosynthetic process (GO:0006754)4.81150582
20* chaperone-mediated protein transport (GO:0072321)4.71586269
21purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.61169909
22mitochondrial respiratory chain complex assembly (GO:0033108)4.60760829
23ribosomal large subunit biogenesis (GO:0042273)4.57748832
24purine nucleoside triphosphate biosynthetic process (GO:0009145)4.49844566
25inner mitochondrial membrane organization (GO:0007007)4.45609510
26proton transport (GO:0015992)4.34823101
27protein complex disassembly (GO:0043241)4.30575323
28hydrogen transport (GO:0006818)4.26650894
29macromolecular complex disassembly (GO:0032984)4.11896519
30ribonucleoside triphosphate biosynthetic process (GO:0009201)3.96078269
31ATP hydrolysis coupled proton transport (GO:0015991)3.95387616
32energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.95387616
33protein targeting to membrane (GO:0006612)3.93074581
34GTP biosynthetic process (GO:0006183)3.91237554
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.83986308
36cellular component biogenesis (GO:0044085)3.81960866
37oxidative phosphorylation (GO:0006119)3.79136935
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.78396661
39regulation of mitochondrial translation (GO:0070129)3.75355211
40ribosomal small subunit biogenesis (GO:0042274)3.74670382
41nuclear-transcribed mRNA catabolic process (GO:0000956)3.71948967
42regulation of oxidative phosphorylation (GO:0002082)3.69116766
43pseudouridine synthesis (GO:0001522)3.60873823
44dopamine transport (GO:0015872)3.60511420
45chromatin remodeling at centromere (GO:0031055)3.59235153
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.52966911
47ribonucleoprotein complex biogenesis (GO:0022613)3.51247825
48mRNA catabolic process (GO:0006402)3.50779561
49CENP-A containing nucleosome assembly (GO:0034080)3.46849075
50nucleoside triphosphate biosynthetic process (GO:0009142)3.46423579
51central nervous system myelination (GO:0022010)3.45330386
52axon ensheathment in central nervous system (GO:0032291)3.45330386
53rRNA modification (GO:0000154)3.43235095
54neuron cell-cell adhesion (GO:0007158)3.41852084
55proteasome assembly (GO:0043248)3.38959874
56substantia nigra development (GO:0021762)3.38648134
57cullin deneddylation (GO:0010388)3.38640903
58* protein targeting to mitochondrion (GO:0006626)3.37492710
59* establishment of protein localization to mitochondrion (GO:0072655)3.36760303
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36025299
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36025299
62water-soluble vitamin biosynthetic process (GO:0042364)3.35124691
63spliceosomal snRNP assembly (GO:0000387)3.33910134
64rRNA processing (GO:0006364)3.32682080
65respiratory chain complex IV assembly (GO:0008535)3.31459497
66cytochrome complex assembly (GO:0017004)3.26701391
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26207398
68* protein localization to mitochondrion (GO:0070585)3.24005991
69RNA catabolic process (GO:0006401)3.22992826
70regulation of catecholamine metabolic process (GO:0042069)3.22249426
71regulation of dopamine metabolic process (GO:0042053)3.22249426
72viral transcription (GO:0019083)3.20130082
73rRNA metabolic process (GO:0016072)3.19531822
74protein deneddylation (GO:0000338)3.15438842
75UTP biosynthetic process (GO:0006228)3.14313898
76sequestering of actin monomers (GO:0042989)3.11877430
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10401242
78translational termination (GO:0006415)3.08909453
79* mitochondrial transport (GO:0006839)3.08278031
80long-chain fatty acid biosynthetic process (GO:0042759)3.07726047
817-methylguanosine mRNA capping (GO:0006370)3.06754993
82aerobic respiration (GO:0009060)3.06625694
837-methylguanosine RNA capping (GO:0009452)3.06001828
84RNA capping (GO:0036260)3.06001828
85regulation of cellular amino acid metabolic process (GO:0006521)3.05855351
86protein-cofactor linkage (GO:0018065)3.04849572
87cotranslational protein targeting to membrane (GO:0006613)3.04591847
88termination of RNA polymerase III transcription (GO:0006386)3.03210044
89transcription elongation from RNA polymerase III promoter (GO:0006385)3.03210044
90regulation of cellular respiration (GO:0043457)3.01211758
91intracellular protein transmembrane import (GO:0044743)2.97248422
92DNA damage response, detection of DNA damage (GO:0042769)2.96704138
93protein targeting to ER (GO:0045047)2.94329379
94transferrin transport (GO:0033572)2.92029370
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91249393
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91249393
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91249393
98SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91101500
99fatty acid elongation (GO:0030497)2.90947649
100establishment of integrated proviral latency (GO:0075713)2.90151558
101base-excision repair, AP site formation (GO:0006285)2.88720351
102intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88244306
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88244306
104regulation of glutamate secretion (GO:0014048)2.86448832
105* protein targeting (GO:0006605)2.86411846
106protein localization to endoplasmic reticulum (GO:0070972)2.85183485
107guanosine-containing compound biosynthetic process (GO:1901070)2.84647985
108dopamine biosynthetic process (GO:0042416)2.82589739
109negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82494286
110establishment of protein localization to endoplasmic reticulum (GO:0072599)2.81766131
111presynaptic membrane assembly (GO:0097105)2.79879417
112presynaptic membrane organization (GO:0097090)2.78481236
113nucleoside diphosphate phosphorylation (GO:0006165)2.77159759
114protein localization to cilium (GO:0061512)2.76385128
115neuronal action potential propagation (GO:0019227)2.74945525
116positive regulation of mitochondrial fission (GO:0090141)2.69725314
117regulation of protein kinase A signaling (GO:0010738)2.68584843
118ferric iron transport (GO:0015682)2.66833508
119trivalent inorganic cation transport (GO:0072512)2.66833508
120negative regulation of ligase activity (GO:0051352)2.65147892
121negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65147892
122cellular protein complex disassembly (GO:0043624)2.65079386
123mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.65072697
124regulation of cellular amine metabolic process (GO:0033238)2.64705738
125UTP metabolic process (GO:0046051)2.64665253
126calcium-mediated signaling using intracellular calcium source (GO:0035584)2.64373981
127translation (GO:0006412)2.62263966
128negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.61800492
129establishment of viral latency (GO:0019043)2.61232218
130purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.61006282
131purine nucleoside monophosphate biosynthetic process (GO:0009127)2.61006282
132DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60700376
133gamma-aminobutyric acid signaling pathway (GO:0007214)2.59506321
134generation of precursor metabolites and energy (GO:0006091)2.58097877
135synaptic vesicle exocytosis (GO:0016079)2.55838062
136neurotransmitter uptake (GO:0001504)2.55808571
137positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54926397
138viral life cycle (GO:0019058)2.54491805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.12840532
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.00638308
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.61577747
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48371421
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.09869193
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.82364288
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.77094305
8VDR_22108803_ChIP-Seq_LS180_Human2.65779290
9TAF15_26573619_Chip-Seq_HEK293_Human2.64432906
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.56314232
11GBX2_23144817_ChIP-Seq_PC3_Human2.56081689
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50482431
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46269498
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43986504
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39856970
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38418710
17XRN2_22483619_ChIP-Seq_HELA_Human2.32051639
18FOXP3_21729870_ChIP-Seq_TREG_Human2.28763460
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24409881
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.22363067
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17339257
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14637666
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11241268
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07245982
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02708082
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01850180
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98338473
28FUS_26573619_Chip-Seq_HEK293_Human1.96167071
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95509140
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89350895
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88340718
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87717642
33E2F7_22180533_ChIP-Seq_HELA_Human1.83784149
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83201728
35* GABP_19822575_ChIP-Seq_HepG2_Human1.81908286
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81763394
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.80862317
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.79005577
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78272156
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77464426
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.76042171
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65030609
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60156132
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58273169
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57804633
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.53276873
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51865606
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50535297
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.48878274
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48457295
51ER_23166858_ChIP-Seq_MCF-7_Human1.47582242
52REST_21632747_ChIP-Seq_MESCs_Mouse1.47147891
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46806843
54P300_19829295_ChIP-Seq_ESCs_Human1.46750466
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44465336
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42726373
57* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40238275
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39958334
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.39907099
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39774153
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38090854
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36582436
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34729545
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33826375
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33339056
66RNF2_27304074_Chip-Seq_NSC_Mouse1.31694365
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31002725
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28055480
69IGF1R_20145208_ChIP-Seq_DFB_Human1.27587819
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26230685
71IRF1_19129219_ChIP-ChIP_H3396_Human1.25700100
72* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25534202
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25329929
74* SOX2_16153702_ChIP-ChIP_HESCs_Human1.24415325
75DCP1A_22483619_ChIP-Seq_HELA_Human1.24396871
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24302412
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24302412
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.23955010
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23858862
80ELK1_19687146_ChIP-ChIP_HELA_Human1.23358678
81MYC_18555785_ChIP-Seq_MESCs_Mouse1.23032095
82VDR_23849224_ChIP-Seq_CD4+_Human1.22466655
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.20815584
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19908409
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19623391
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18792103
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17413409
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16504627
89ZNF274_21170338_ChIP-Seq_K562_Hela1.14140654
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.11160625
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10973521
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10916148
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10314443
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10275881
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09677514
96* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09443434
97NANOG_16153702_ChIP-ChIP_HESCs_Human1.09206567
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.07881842
99JUN_21703547_ChIP-Seq_K562_Human1.07175273
100MYC_18940864_ChIP-ChIP_HL60_Human1.06876601
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.06715720
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06031844
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05940662
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05485648
105EWS_26573619_Chip-Seq_HEK293_Human1.04433861
106E2F1_21310950_ChIP-Seq_MCF-7_Human1.04329380
107* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03816543
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03777409
109MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01134871
110KDM5A_27292631_Chip-Seq_BREAST_Human1.00219470
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99726749
112HTT_18923047_ChIP-ChIP_STHdh_Human0.99589811
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99160124
114REST_19997604_ChIP-ChIP_NEURONS_Mouse0.99107481
115* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99051213
116CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99032463
117SMAD3_21741376_ChIP-Seq_EPCs_Human0.98767679
118NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98698545
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98225317
120TP53_22573176_ChIP-Seq_HFKS_Human0.96917977
121TP63_19390658_ChIP-ChIP_HaCaT_Human0.95864897
122* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95392647
123TTF2_22483619_ChIP-Seq_HELA_Human0.92753412
124* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91722065
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.90981275
126* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89060849
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88478061
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88367573
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87493213
130TAL1_26923725_Chip-Seq_HPCs_Mouse0.87393445
131* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86449647
132SMAD4_21799915_ChIP-Seq_A2780_Human0.85835371
133RNF2_27304074_Chip-Seq_ESCs_Mouse0.84891577
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84692929
135* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84192085
136NANOG_19829295_ChIP-Seq_ESCs_Human0.84081616
137SOX2_19829295_ChIP-Seq_ESCs_Human0.84081616
138ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83828021
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83144323
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81953961
141SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81573758
142POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81499822
143FOXM1_23109430_ChIP-Seq_U2OS_Human0.80320305
144FOXP1_21924763_ChIP-Seq_HESCs_Human0.77910815
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76241045
146ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74766414
147SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74316482
148ERG_20517297_ChIP-Seq_VCAP_Human0.71125200
149NOTCH1_21737748_ChIP-Seq_TLL_Human0.70478688
150* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.70020533
151NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68423655
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.64430018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.51508800
2MP0001529_abnormal_vocalization3.97983214
3MP0006276_abnormal_autonomic_nervous3.14339753
4MP0001905_abnormal_dopamine_level3.09150931
5MP0009379_abnormal_foot_pigmentation2.80079514
6MP0001968_abnormal_touch/_nociception2.48834760
7MP0002837_dystrophic_cardiac_calcinosis2.46876141
8MP0002736_abnormal_nociception_after2.45747805
9MP0009745_abnormal_behavioral_response2.44051945
10MP0008058_abnormal_DNA_repair2.39295947
11MP0003011_delayed_dark_adaptation2.38009888
12MP0003635_abnormal_synaptic_transmissio2.37140879
13MP0002064_seizures2.33603127
14MP0009046_muscle_twitch2.30869797
15MP0003693_abnormal_embryo_hatching2.27316430
16MP0002272_abnormal_nervous_system2.26901278
17MP0004859_abnormal_synaptic_plasticity2.25198954
18MP0001440_abnormal_grooming_behavior2.21769500
19MP0004270_analgesia2.20875464
20MP0004142_abnormal_muscle_tone2.19814636
21MP0003136_yellow_coat_color2.13721025
22MP0003806_abnormal_nucleotide_metabolis2.09504620
23MP0004957_abnormal_blastocyst_morpholog2.06222320
24MP0002572_abnormal_emotion/affect_behav2.05995003
25MP0002734_abnormal_mechanical_nocicepti2.02607229
26MP0002653_abnormal_ependyma_morphology1.98267933
27MP0005423_abnormal_somatic_nervous1.97423229
28MP0001293_anophthalmia1.97406596
29MP0002063_abnormal_learning/memory/cond1.95149740
30MP0010030_abnormal_orbit_morphology1.90636186
31MP0002735_abnormal_chemical_nociception1.83430782
32MP0001486_abnormal_startle_reflex1.77473357
33MP0006036_abnormal_mitochondrial_physio1.75513453
34MP0002638_abnormal_pupillary_reflex1.72897921
35MP0003646_muscle_fatigue1.71156142
36MP0005386_behavior/neurological_phenoty1.70085103
37MP0004924_abnormal_behavior1.70085103
38MP0002067_abnormal_sensory_capabilities1.67495923
39MP0001970_abnormal_pain_threshold1.65129558
40MP0006035_abnormal_mitochondrial_morpho1.65063914
41MP0000778_abnormal_nervous_system1.64582071
42MP0010094_abnormal_chromosome_stability1.63339979
43MP0001501_abnormal_sleep_pattern1.61188001
44MP0002733_abnormal_thermal_nociception1.59740486
45MP0003123_paternal_imprinting1.58272461
46MP0002822_catalepsy1.55522747
47MP0002102_abnormal_ear_morphology1.54439433
48MP0005084_abnormal_gallbladder_morpholo1.52089339
49MP0010386_abnormal_urinary_bladder1.50207671
50MP0000049_abnormal_middle_ear1.49675526
51MP0001188_hyperpigmentation1.49272756
52MP0008932_abnormal_embryonic_tissue1.48998793
53MP0002277_abnormal_respiratory_mucosa1.45578941
54MP0003122_maternal_imprinting1.45362729
55MP0001984_abnormal_olfaction1.44932847
56MP0002163_abnormal_gland_morphology1.42254201
57MP0003077_abnormal_cell_cycle1.41208854
58MP0003111_abnormal_nucleus_morphology1.41207840
59MP0002160_abnormal_reproductive_system1.41168047
60MP0002184_abnormal_innervation1.40977599
61MP0008995_early_reproductive_senescence1.38589928
62MP0005410_abnormal_fertilization1.36846232
63MP0003121_genomic_imprinting1.36357609
64MP0003786_premature_aging1.35908807
65MP0004742_abnormal_vestibular_system1.35144072
66MP0005171_absent_coat_pigmentation1.34232662
67MP0001485_abnormal_pinna_reflex1.26804140
68MP0004145_abnormal_muscle_electrophysio1.26177718
69MP0005379_endocrine/exocrine_gland_phen1.25398539
70MP0002234_abnormal_pharynx_morphology1.24986153
71MP0002876_abnormal_thyroid_physiology1.23814899
72MP0006072_abnormal_retinal_apoptosis1.22455917
73MP0006292_abnormal_olfactory_placode1.19827376
74MP0005409_darkened_coat_color1.19720642
75MP0000920_abnormal_myelination1.17596444
76MP0005551_abnormal_eye_electrophysiolog1.17516659
77MP0002557_abnormal_social/conspecific_i1.15633925
78MP0001727_abnormal_embryo_implantation1.15411086
79MP0005389_reproductive_system_phenotype1.12746720
80MP0002066_abnormal_motor_capabilities/c1.12484162
81MP0003941_abnormal_skin_development1.10909596
82MP0000751_myopathy1.10715008
83MP0004215_abnormal_myocardial_fiber1.10713079
84MP0000372_irregular_coat_pigmentation1.09825140
85MP0003329_amyloid_beta_deposits1.09650929
86MP0004133_heterotaxia1.09222681
87MP0005646_abnormal_pituitary_gland1.07786849
88MP0002233_abnormal_nose_morphology1.06667879
89MP0002882_abnormal_neuron_morphology1.05663169
90MP0005645_abnormal_hypothalamus_physiol1.04993486
91MP0002332_abnormal_exercise_endurance1.03862451
92MP0001963_abnormal_hearing_physiology1.03034856
93MP0002229_neurodegeneration1.02839804
94MP0002095_abnormal_skin_pigmentation1.01648534
95MP0002752_abnormal_somatic_nervous1.01381976
96MP0000026_abnormal_inner_ear1.00369925
97MP0008875_abnormal_xenobiotic_pharmacok1.00277853
98MP0008007_abnormal_cellular_replicative0.99478242
99MP0002210_abnormal_sex_determination0.98681997
100MP0008789_abnormal_olfactory_epithelium0.97207207
101MP0004036_abnormal_muscle_relaxation0.96886342
102MP0009697_abnormal_copulation0.96647640
103MP0003137_abnormal_impulse_conducting0.96475899
104MP0003937_abnormal_limbs/digits/tail_de0.95330416
105MP0000955_abnormal_spinal_cord0.95051751
106MP0005499_abnormal_olfactory_system0.94860313
107MP0005394_taste/olfaction_phenotype0.94860313
108MP0001502_abnormal_circadian_rhythm0.93983258
109MP0001764_abnormal_homeostasis0.93872981
110MP0000631_abnormal_neuroendocrine_gland0.92394158
111MP0004147_increased_porphyrin_level0.91592403
112MP0003787_abnormal_imprinting0.91584775
113MP0003718_maternal_effect0.91378364
114MP0001286_abnormal_eye_development0.91268979
115MP0001919_abnormal_reproductive_system0.90886184
116MP0003567_abnormal_fetal_cardiomyocyte0.90531748
117MP0008877_abnormal_DNA_methylation0.88756852
118MP0003283_abnormal_digestive_organ0.88208500
119MP0004043_abnormal_pH_regulation0.87682189
120MP0003315_abnormal_perineum_morphology0.87559509
121MP0005195_abnormal_posterior_eye0.85374172
122MP0003195_calcinosis0.83981835
123MP0001986_abnormal_taste_sensitivity0.83535692
124MP0000749_muscle_degeneration0.83282974
125MP0008872_abnormal_physiological_respon0.82560029
126MP0005535_abnormal_body_temperature0.81131696
127MP0005253_abnormal_eye_physiology0.78733569
128MP0005391_vision/eye_phenotype0.78121764
129MP0003938_abnormal_ear_development0.77949171
130MP0003186_abnormal_redox_activity0.77356581
131MP0004484_altered_response_of0.76391037
132MP0000566_synostosis0.74838895
133MP0002751_abnormal_autonomic_nervous0.74716349
134MP0000653_abnormal_sex_gland0.74332889
135MP0003119_abnormal_digestive_system0.73883034
136MP0004811_abnormal_neuron_physiology0.73864320
137MP0001145_abnormal_male_reproductive0.73527933
138MP0003634_abnormal_glial_cell0.73040598
139MP0008569_lethality_at_weaning0.72777178
140MP0001664_abnormal_digestion0.72776962
141MP0002697_abnormal_eye_size0.72535942
142MP0000538_abnormal_urinary_bladder0.71908331
143MP0005332_abnormal_amino_acid0.71029813
144MP0005408_hypopigmentation0.70068411
145MP0008260_abnormal_autophagy0.68883891
146MP0002282_abnormal_trachea_morphology0.68781108
147MP0002152_abnormal_brain_morphology0.67896066
148MP0002938_white_spotting0.67138388

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.74004506
2Abnormal mitochondria in muscle tissue (HP:0008316)6.96509876
3Progressive macrocephaly (HP:0004481)6.57256077
4Mitochondrial inheritance (HP:0001427)6.48337206
5Acute encephalopathy (HP:0006846)6.28467442
6Increased CSF lactate (HP:0002490)5.40384707
7Hepatocellular necrosis (HP:0001404)5.10806597
8Increased hepatocellular lipid droplets (HP:0006565)5.10119470
9Lipid accumulation in hepatocytes (HP:0006561)4.50244869
10Renal Fanconi syndrome (HP:0001994)4.45364929
11Cerebral edema (HP:0002181)4.32866705
12Hepatic necrosis (HP:0002605)4.22856278
13Reticulocytopenia (HP:0001896)4.19578214
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.16738833
15Abnormality of glycolysis (HP:0004366)4.12431389
16Increased serum pyruvate (HP:0003542)4.12431389
17Optic disc pallor (HP:0000543)4.12016132
18Leukodystrophy (HP:0002415)3.99356921
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.82152530
20Exercise intolerance (HP:0003546)3.80605590
21Increased intramyocellular lipid droplets (HP:0012240)3.78994978
22Respiratory failure (HP:0002878)3.73070826
233-Methylglutaconic aciduria (HP:0003535)3.64541328
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.56837681
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.56837681
26Lactic acidosis (HP:0003128)3.48273581
27Myokymia (HP:0002411)3.33273693
28Exertional dyspnea (HP:0002875)3.25179079
29Focal motor seizures (HP:0011153)3.25140614
30Increased serum lactate (HP:0002151)3.15523402
31Increased muscle lipid content (HP:0009058)3.10865876
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.05131584
33Pallor (HP:0000980)3.02311629
34Abnormality of renal resorption (HP:0011038)2.92937326
35Congenital, generalized hypertrichosis (HP:0004540)2.81571524
36Respiratory difficulties (HP:0002880)2.79215700
37Aplastic anemia (HP:0001915)2.75201378
38X-linked dominant inheritance (HP:0001423)2.74022922
39Pheochromocytoma (HP:0002666)2.71516314
40Neuroendocrine neoplasm (HP:0100634)2.71306680
41Parakeratosis (HP:0001036)2.68033421
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.65497992
43Abnormality of cells of the erythroid lineage (HP:0012130)2.64194017
44Colon cancer (HP:0003003)2.61046814
45Oral leukoplakia (HP:0002745)2.51665143
46Sensory axonal neuropathy (HP:0003390)2.50441520
47Atonic seizures (HP:0010819)2.49621914
48Septo-optic dysplasia (HP:0100842)2.45295680
49Pancreatic fibrosis (HP:0100732)2.43904166
50Medial flaring of the eyebrow (HP:0010747)2.35970166
51Emotional lability (HP:0000712)2.28746205
52Hyperphosphaturia (HP:0003109)2.28721642
53CNS demyelination (HP:0007305)2.28637530
54Pancreatic cysts (HP:0001737)2.26282153
55Hypothermia (HP:0002045)2.25754551
56Molar tooth sign on MRI (HP:0002419)2.25616310
57Abnormality of midbrain morphology (HP:0002418)2.25616310
58Abnormal number of erythroid precursors (HP:0012131)2.24163944
59True hermaphroditism (HP:0010459)2.20052985
60Gait imbalance (HP:0002141)2.15432610
61Abnormality of the labia minora (HP:0012880)2.14812893
62Delusions (HP:0000746)2.13788903
63Sclerocornea (HP:0000647)2.13429879
64Generalized aminoaciduria (HP:0002909)2.13284698
65Hyperglycinemia (HP:0002154)2.10193580
66Limb dystonia (HP:0002451)2.09044826
67Muscle hypertrophy of the lower extremities (HP:0008968)2.07814337
68Abnormal hair whorl (HP:0010721)2.07200843
69Absence seizures (HP:0002121)2.06913704
70Retinal dysplasia (HP:0007973)2.05471533
71Congenital primary aphakia (HP:0007707)2.05468014
72Rib fusion (HP:0000902)2.03276586
73Glycosuria (HP:0003076)2.02650089
74Abnormality of urine glucose concentration (HP:0011016)2.02650089
75Lethargy (HP:0001254)1.99752530
76Type I transferrin isoform profile (HP:0003642)1.98241750
77Hyperventilation (HP:0002883)1.95430704
78Nephrogenic diabetes insipidus (HP:0009806)1.94774240
79Dialeptic seizures (HP:0011146)1.94351902
80Dynein arm defect of respiratory motile cilia (HP:0012255)1.93757828
81Absent/shortened dynein arms (HP:0200106)1.93757828
82Absent thumb (HP:0009777)1.93664832
83Epileptic encephalopathy (HP:0200134)1.92842801
84Macrocytic anemia (HP:0001972)1.90450407
85Amniotic constriction ring (HP:0009775)1.90404351
86Abnormality of placental membranes (HP:0011409)1.90404351
87Congenital ichthyosiform erythroderma (HP:0007431)1.89489201
88Degeneration of the lateral corticospinal tracts (HP:0002314)1.87923316
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87923316
90Abnormal ciliary motility (HP:0012262)1.87071972
91Abnormal urine phosphate concentration (HP:0012599)1.86822070
92Calf muscle hypertrophy (HP:0008981)1.85984506
93Cerebral hypomyelination (HP:0006808)1.85712161
94Renal tubular dysfunction (HP:0000124)1.84854508
95Abnormal respiratory motile cilium morphology (HP:0005938)1.83819081
96Abnormal respiratory epithelium morphology (HP:0012253)1.83819081
97Vaginal atresia (HP:0000148)1.83193851
98Absent septum pellucidum (HP:0001331)1.81785434
99Degeneration of anterior horn cells (HP:0002398)1.81388016
100Abnormality of the anterior horn cell (HP:0006802)1.81388016
101Genital tract atresia (HP:0001827)1.80386412
102Abnormal pupillary function (HP:0007686)1.80365947
103Pancytopenia (HP:0001876)1.80217202
104Microvesicular hepatic steatosis (HP:0001414)1.79777893
105Stenosis of the external auditory canal (HP:0000402)1.79575738
106Nephronophthisis (HP:0000090)1.77714832
107Broad-based gait (HP:0002136)1.76221442
108Polyphagia (HP:0002591)1.75223086
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74584056
110Abnormality of serum amino acid levels (HP:0003112)1.74393670
111Progressive inability to walk (HP:0002505)1.73904094
112Megaloblastic anemia (HP:0001889)1.73630385
113Pendular nystagmus (HP:0012043)1.73104270
114Focal seizures (HP:0007359)1.71161365
115Anxiety (HP:0000739)1.69865706
116Blindness (HP:0000618)1.69227058
117Esotropia (HP:0000565)1.68753370
118Abnormal respiratory motile cilium physiology (HP:0012261)1.68258180
119Visual hallucinations (HP:0002367)1.68032178
120Abnormality of dicarboxylic acid metabolism (HP:0010995)1.67675793
121Dicarboxylic aciduria (HP:0003215)1.67675793
122Anencephaly (HP:0002323)1.66827510
123Cerebral hemorrhage (HP:0001342)1.66100118
124Triphalangeal thumb (HP:0001199)1.65402317
125Methylmalonic acidemia (HP:0002912)1.65365580
126Poor suck (HP:0002033)1.65090811
127Sparse eyelashes (HP:0000653)1.63181384
128Depressed nasal ridge (HP:0000457)1.62776513
129Abnormality of alanine metabolism (HP:0010916)1.62662099
130Hyperalaninemia (HP:0003348)1.62662099
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62662099
132Progressive external ophthalmoplegia (HP:0000590)1.62394255
133Male pseudohermaphroditism (HP:0000037)1.62150446
134Abnormal number of incisors (HP:0011064)1.61486829
135Amblyopia (HP:0000646)1.61483753
136Cleft eyelid (HP:0000625)1.60948914
137Abnormal protein glycosylation (HP:0012346)1.59974703
138Abnormal glycosylation (HP:0012345)1.59974703
139Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59974703
140Abnormal protein N-linked glycosylation (HP:0012347)1.59974703
141Methylmalonic aciduria (HP:0012120)1.59378740
142Febrile seizures (HP:0002373)1.58689501
143Neurofibrillary tangles (HP:0002185)1.57819108
144Abnormality of methionine metabolism (HP:0010901)1.56763481
145Testicular atrophy (HP:0000029)1.56707012
146Maternal diabetes (HP:0009800)1.56680934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.35686915
2MAP3K123.76949675
3NME12.85085852
4ZAK2.80484160
5CASK2.78200920
6CDC72.77928993
7STK392.61571474
8CDK192.51943336
9STK162.51219857
10ARAF2.48660226
11PNCK2.21985759
12OXSR12.20000946
13MAP2K72.18742592
14PBK2.15418503
15BCKDK2.15105552
16EPHA42.08441970
17NME22.07845897
18GRK51.97606769
19NUAK11.91280385
20MYLK1.89986502
21GRK71.73624372
22BCR1.73604810
23MAP3K41.69354442
24LIMK11.68650779
25MST41.65578186
26TNIK1.63659349
27WNK41.59005189
28NEK11.57933741
29MARK11.57207650
30NTRK31.54787916
31MUSK1.54401061
32RIPK41.52938885
33PLK21.50396665
34TAF11.48912858
35VRK11.45923021
36TLK11.45378893
37BMPR1B1.42871398
38BMPR21.36543279
39MAPK131.34229754
40BUB11.29325049
41MAP4K21.28734950
42PLK11.27219635
43DYRK21.26329083
44DYRK31.23603097
45ADRBK21.22483920
46TTK1.22474763
47BRAF1.21170436
48CAMK2B1.19693381
49FGR1.19212097
50MAPKAPK51.16874973
51MINK11.15701190
52CAMK2A1.12388820
53GRK11.06989284
54UHMK11.04593199
55MAP2K41.04496893
56BRSK21.04315769
57AURKB1.04261240
58OBSCN0.99746270
59ABL20.99201357
60SRPK10.97737854
61EIF2AK10.96274664
62CSNK1G30.95624425
63WNK30.92355712
64CAMK2D0.91149284
65INSRR0.90926519
66CHEK20.90479273
67EPHB20.88242554
68CSNK2A20.86048188
69PTK2B0.85599838
70PINK10.83215619
71ADRBK10.82041447
72MKNK10.81007465
73CAMK2G0.79430545
74PKN10.78667002
75MAP3K90.78574842
76CDK140.77618541
77CCNB10.77350221
78KDR0.76751290
79ROCK20.76434397
80DAPK10.75215886
81ATR0.75155377
82BRSK10.74913303
83MKNK20.73213235
84CDK180.73079641
85NTRK20.71520804
86DAPK30.71331362
87CDK150.68566261
88NEK60.67803697
89IRAK20.67703437
90CDK11A0.65829707
91PRKCG0.65520178
92PDK40.64718651
93PDK30.64718651
94CDK50.63985287
95CSNK1G20.62981907
96KSR10.61572214
97ERBB40.60161267
98TRIM280.59804649
99PIM20.59444957
100PRKCE0.58178536
101CDK80.56493461
102PASK0.55583897
103PHKG20.55437600
104PHKG10.55437600
105LRRK20.54252655
106WEE10.53787141
107EIF2AK30.53424299
108TSSK60.52186298
109CSNK1G10.51999784
110CSNK1A1L0.51685777
111CSNK1E0.51082361
112PRKACA0.50752148
113TESK10.49029139
114STK40.48546530
115AURKA0.48486985
116PLK40.48292912
117NEK20.47497814
118CSNK1A10.46356977
119AKT30.46022711
120MOS0.45670547
121NTRK10.45205295
122PDK20.45155115
123ILK0.43657688
124DYRK1A0.43621767
125PLK30.42265032
126MAPK150.40730015
127YES10.39414638
128CDK30.39393618
129RPS6KA40.39331957
130TESK20.38533772
131TIE10.38195890
132MAP3K110.37929387
133RAF10.36980743
134DAPK20.36770979
135PRKCI0.36714240
136RPS6KA50.36544746
137ATM0.36170081
138GRK60.35268573
139CSNK2A10.34779745
140PRPF4B0.34345279
141EIF2AK20.33558334
142PAK30.32695212

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001906.63105682
2Parkinsons disease_Homo sapiens_hsa050125.51419086
3Alzheimers disease_Homo sapiens_hsa050104.30129204
4Huntingtons disease_Homo sapiens_hsa050164.00350589
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.33738045
6Proteasome_Homo sapiens_hsa030503.31559510
7Ribosome_Homo sapiens_hsa030103.31420396
8Cardiac muscle contraction_Homo sapiens_hsa042602.91953821
9Collecting duct acid secretion_Homo sapiens_hsa049662.68282878
10Protein export_Homo sapiens_hsa030602.33888924
11Mismatch repair_Homo sapiens_hsa034302.27150737
12DNA replication_Homo sapiens_hsa030302.24978262
13RNA polymerase_Homo sapiens_hsa030202.20763536
14Nicotine addiction_Homo sapiens_hsa050332.07688411
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91639149
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89179766
17Synaptic vesicle cycle_Homo sapiens_hsa047211.71504326
18Vibrio cholerae infection_Homo sapiens_hsa051101.59080503
19Sulfur relay system_Homo sapiens_hsa041221.47629436
20Base excision repair_Homo sapiens_hsa034101.45476928
21Fatty acid elongation_Homo sapiens_hsa000621.44786580
22Folate biosynthesis_Homo sapiens_hsa007901.41442277
23One carbon pool by folate_Homo sapiens_hsa006701.35644205
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32093002
25Fanconi anemia pathway_Homo sapiens_hsa034601.28271013
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23204226
27Serotonergic synapse_Homo sapiens_hsa047261.20733367
28Sulfur metabolism_Homo sapiens_hsa009201.16731958
29RNA transport_Homo sapiens_hsa030131.16292313
30GABAergic synapse_Homo sapiens_hsa047271.13454383
31Rheumatoid arthritis_Homo sapiens_hsa053231.07102201
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06742647
33Phototransduction_Homo sapiens_hsa047440.99048435
34Pyrimidine metabolism_Homo sapiens_hsa002400.96024647
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95091964
36Morphine addiction_Homo sapiens_hsa050320.93441589
37Pyruvate metabolism_Homo sapiens_hsa006200.92839822
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91494336
39Basal transcription factors_Homo sapiens_hsa030220.90655118
40Glutamatergic synapse_Homo sapiens_hsa047240.90235512
41Ether lipid metabolism_Homo sapiens_hsa005650.89322693
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88216751
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87183840
44Taste transduction_Homo sapiens_hsa047420.85673040
45Amphetamine addiction_Homo sapiens_hsa050310.83038295
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81865318
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81852693
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80006259
49Dopaminergic synapse_Homo sapiens_hsa047280.79466711
50Non-homologous end-joining_Homo sapiens_hsa034500.78799662
51Metabolic pathways_Homo sapiens_hsa011000.77838788
52Circadian entrainment_Homo sapiens_hsa047130.76246645
53Steroid biosynthesis_Homo sapiens_hsa001000.75905675
54Long-term potentiation_Homo sapiens_hsa047200.73171075
55Long-term depression_Homo sapiens_hsa047300.70817792
56Purine metabolism_Homo sapiens_hsa002300.68098597
57Tryptophan metabolism_Homo sapiens_hsa003800.64573408
58Selenocompound metabolism_Homo sapiens_hsa004500.62778925
59Phagosome_Homo sapiens_hsa041450.60283968
60Butanoate metabolism_Homo sapiens_hsa006500.59753900
61Cell cycle_Homo sapiens_hsa041100.59070348
62Spliceosome_Homo sapiens_hsa030400.59020770
63Chemical carcinogenesis_Homo sapiens_hsa052040.58488816
64Caffeine metabolism_Homo sapiens_hsa002320.57443596
65Propanoate metabolism_Homo sapiens_hsa006400.57001408
66Vitamin digestion and absorption_Homo sapiens_hsa049770.56880603
67Nucleotide excision repair_Homo sapiens_hsa034200.56704138
68Olfactory transduction_Homo sapiens_hsa047400.56231309
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55903644
70Tyrosine metabolism_Homo sapiens_hsa003500.55551078
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54308124
72Glutathione metabolism_Homo sapiens_hsa004800.54196926
73Linoleic acid metabolism_Homo sapiens_hsa005910.53943251
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.53431153
75Calcium signaling pathway_Homo sapiens_hsa040200.51991306
76Renin secretion_Homo sapiens_hsa049240.50188438
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50089986
78Cocaine addiction_Homo sapiens_hsa050300.49005101
79Nitrogen metabolism_Homo sapiens_hsa009100.47870435
80Arachidonic acid metabolism_Homo sapiens_hsa005900.47067580
81Salivary secretion_Homo sapiens_hsa049700.46941594
82Phenylalanine metabolism_Homo sapiens_hsa003600.46313395
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.46074735
84Retinol metabolism_Homo sapiens_hsa008300.45861156
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45350140
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44931916
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44816937
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44784599
89Alcoholism_Homo sapiens_hsa050340.42823393
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.42197560
91Regulation of autophagy_Homo sapiens_hsa041400.42019461
92Cholinergic synapse_Homo sapiens_hsa047250.40745038
93Systemic lupus erythematosus_Homo sapiens_hsa053220.40596206
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40484649
95RNA degradation_Homo sapiens_hsa030180.38410667
96Homologous recombination_Homo sapiens_hsa034400.37956754
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.37375306
98Fatty acid degradation_Homo sapiens_hsa000710.36357178
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36334151
100Type I diabetes mellitus_Homo sapiens_hsa049400.36159283
101beta-Alanine metabolism_Homo sapiens_hsa004100.35321685
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34700263
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32346008
104Carbon metabolism_Homo sapiens_hsa012000.32111533
105Axon guidance_Homo sapiens_hsa043600.31844267
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31366928
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30703587
108Gastric acid secretion_Homo sapiens_hsa049710.30244562
109Basal cell carcinoma_Homo sapiens_hsa052170.29289973
110Oocyte meiosis_Homo sapiens_hsa041140.29127896
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28836554
112Oxytocin signaling pathway_Homo sapiens_hsa049210.27911576
113Sphingolipid metabolism_Homo sapiens_hsa006000.27316455
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27249209
115Arginine and proline metabolism_Homo sapiens_hsa003300.25664048
116African trypanosomiasis_Homo sapiens_hsa051430.25008088
117Fat digestion and absorption_Homo sapiens_hsa049750.24564670
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24356892
119Biosynthesis of amino acids_Homo sapiens_hsa012300.23219457
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22430512
121Gap junction_Homo sapiens_hsa045400.21957750
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.21957329
123Vitamin B6 metabolism_Homo sapiens_hsa007500.21757753
124Graft-versus-host disease_Homo sapiens_hsa053320.21575801
125mRNA surveillance pathway_Homo sapiens_hsa030150.20714253
126p53 signaling pathway_Homo sapiens_hsa041150.20529313
127Asthma_Homo sapiens_hsa053100.20345276
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19814425
129Insulin secretion_Homo sapiens_hsa049110.19595205
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19313922
131Hedgehog signaling pathway_Homo sapiens_hsa043400.18891438
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.17890185
133Mineral absorption_Homo sapiens_hsa049780.17782330
134Fatty acid metabolism_Homo sapiens_hsa012120.16999968
135Peroxisome_Homo sapiens_hsa041460.16783374
136Epstein-Barr virus infection_Homo sapiens_hsa051690.15787970
137Autoimmune thyroid disease_Homo sapiens_hsa053200.14543823
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.13092312
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13024545
140Histidine metabolism_Homo sapiens_hsa003400.12947962
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.11899195
142Melanogenesis_Homo sapiens_hsa049160.11697735

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