TIMM8AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.89229426
2DNA deamination (GO:0045006)9.74964059
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450919.34191556
4regulation of interleukin-12 biosynthetic process (GO:0045075)6.39767019
5positive regulation of osteoclast differentiation (GO:0045672)6.07477626
6regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.40068711
7myeloid dendritic cell differentiation (GO:0043011)5.34446440
8regulation of immunoglobulin secretion (GO:0051023)5.26896380
9regulation of interleukin-6 biosynthetic process (GO:0045408)5.03564266
10cellular response to interleukin-15 (GO:0071350)4.95485659
11signal peptide processing (GO:0006465)4.87505893
12myeloid dendritic cell activation (GO:0001773)4.85996671
13response to interleukin-15 (GO:0070672)4.73424672
14positive regulation of defense response to virus by host (GO:0002230)4.61899576
15chaperone-mediated protein transport (GO:0072321)4.61336677
16positive regulation of transcription regulatory region DNA binding (GO:2000679)4.55279323
17pyrimidine nucleoside catabolic process (GO:0046135)4.53395208
18regulation of interleukin-2 biosynthetic process (GO:0045076)4.50141714
19negative regulation of thymocyte apoptotic process (GO:0070244)4.42951116
20positive regulation of T cell cytokine production (GO:0002726)4.40972913
21negative regulation of viral genome replication (GO:0045071)4.34100229
22eosinophil chemotaxis (GO:0048245)4.33673215
23T-helper 1 type immune response (GO:0042088)4.14481128
24T cell migration (GO:0072678)4.06333732
25regulation of interleukin-8 biosynthetic process (GO:0045414)4.05610221
26negative regulation by host of viral transcription (GO:0043922)3.88017596
27eosinophil migration (GO:0072677)3.87571545
28regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.63008015
29cytolysis (GO:0019835)3.50147010
30negative regulation of T cell apoptotic process (GO:0070233)3.46191979
31macrophage chemotaxis (GO:0048246)3.39453468
32regulation of viral genome replication (GO:0045069)3.38732137
33T cell apoptotic process (GO:0070231)3.35024917
34negative regulation of B cell proliferation (GO:0030889)3.34661375
35pyrimidine ribonucleoside metabolic process (GO:0046131)3.32934972
36positive regulation of interleukin-1 beta secretion (GO:0050718)3.22465409
37negative regulation of viral process (GO:0048525)3.18195358
38regulation of T-helper 1 cell differentiation (GO:0045625)3.16115991
39DNA double-strand break processing (GO:0000729)3.15703053
40regulation of defense response to virus by host (GO:0050691)3.15151642
41NIK/NF-kappaB signaling (GO:0038061)3.14624434
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13212916
43cellular response to interleukin-1 (GO:0071347)3.12641278
44lymphocyte chemotaxis (GO:0048247)3.11884137
45DNA demethylation (GO:0080111)3.10807784
46cytokine biosynthetic process (GO:0042089)3.07684258
47regulation of thymocyte apoptotic process (GO:0070243)3.04791267
48positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.03364909
49positive regulation of interleukin-1 secretion (GO:0050716)3.02595686
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.02373261
51positive regulation of myeloid leukocyte differentiation (GO:0002763)3.00145647
52lymphocyte apoptotic process (GO:0070227)2.99015212
53regulation of interleukin-1 beta secretion (GO:0050706)2.98302597
54dendritic cell differentiation (GO:0097028)2.97963545
55regulation of lymphocyte chemotaxis (GO:1901623)2.97405249
56positive regulation of calcium-mediated signaling (GO:0050850)2.97364793
57regulation of regulatory T cell differentiation (GO:0045589)2.95069220
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87645244
59pyrimidine-containing compound catabolic process (GO:0072529)2.86565040
60negative regulation of lymphocyte apoptotic process (GO:0070229)2.86196434
61regulation of T cell cytokine production (GO:0002724)2.84652665
62negative regulation of viral transcription (GO:0032897)2.80097958
63poly(A)+ mRNA export from nucleus (GO:0016973)2.79694591
64response to interferon-beta (GO:0035456)2.78940565
65regulation of cellular amino acid metabolic process (GO:0006521)2.76652964
66interleukin-1-mediated signaling pathway (GO:0070498)2.74964316
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.74661179
68alpha-beta T cell differentiation (GO:0046632)2.73087107
69positive regulation of interleukin-2 production (GO:0032743)2.72830636
70negative regulation of B cell activation (GO:0050869)2.72485293
71positive regulation of interleukin-8 secretion (GO:2000484)2.72371449
72regulation of interleukin-2 production (GO:0032663)2.72187602
73regulation of interleukin-1 secretion (GO:0050704)2.71226894
74regulation of T cell apoptotic process (GO:0070232)2.70152519
75response to acidic pH (GO:0010447)2.69756885
76negative regulation of interleukin-12 production (GO:0032695)2.69638675
77granulocyte activation (GO:0036230)2.69485974
78positive regulation of alpha-beta T cell proliferation (GO:0046641)2.68554942
79iron-sulfur cluster assembly (GO:0016226)2.66383932
80metallo-sulfur cluster assembly (GO:0031163)2.66383932
81positive regulation of lymphocyte migration (GO:2000403)2.64013666
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.62828597
83regulation of B cell receptor signaling pathway (GO:0050855)2.59016057
84membrane protein intracellular domain proteolysis (GO:0031293)2.58189670
85cytokine metabolic process (GO:0042107)2.57994490
86lymphocyte migration (GO:0072676)2.57417705
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.56717549
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.56705737
89negative regulation of ligase activity (GO:0051352)2.56705737
90positive regulation of interleukin-1 beta production (GO:0032731)2.56346749
91antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.54895725
92lymph node development (GO:0048535)2.53919780
93leukocyte apoptotic process (GO:0071887)2.52602578
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.51569728
95regulation of osteoclast differentiation (GO:0045670)2.51176021
96positive regulation of T cell mediated immunity (GO:0002711)2.50134016
97regulation of cytokine production involved in inflammatory response (GO:1900015)11.8284680
98cytidine deamination (GO:0009972)11.0327678
99cytidine metabolic process (GO:0046087)11.0327678
100cytidine catabolic process (GO:0006216)11.0327678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.72571849
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.16138405
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.93023619
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.75557589
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43023393
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19588682
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.06987813
8STAT4_19710469_ChIP-ChIP_TH1__Mouse2.95456184
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84005966
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.77461536
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68698589
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66682997
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54233587
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.22743884
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19750944
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14579945
17RUNX_20019798_ChIP-Seq_JUKART_Human2.12911489
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11708078
19VDR_23849224_ChIP-Seq_CD4+_Human2.06459830
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.04384199
21BP1_19119308_ChIP-ChIP_Hs578T_Human10.3667677
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94050242
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.91622661
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.86928354
25MYB_26560356_Chip-Seq_TH2_Human1.83210685
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82781265
27HTT_18923047_ChIP-ChIP_STHdh_Human1.82535202
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.76079666
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75571629
30ZNF274_21170338_ChIP-Seq_K562_Hela1.74065183
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.66391347
32ZNF263_19887448_ChIP-Seq_K562_Human1.65493828
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62219850
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61764477
35DCP1A_22483619_ChIP-Seq_HELA_Human1.60999916
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56930385
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.52743836
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.46715403
39FOXP3_21729870_ChIP-Seq_TREG_Human1.44460932
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43486634
41PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.43369672
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38618819
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37179021
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31148919
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30376021
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30066501
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30009196
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28321249
49MYB_26560356_Chip-Seq_TH1_Human1.26130239
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24666631
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23850059
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22673181
53MAF_26560356_Chip-Seq_TH1_Human1.17228227
54GATA3_26560356_Chip-Seq_TH2_Human1.16581638
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14020196
56GATA3_27048872_Chip-Seq_THYMUS_Human1.13345102
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10046275
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06965338
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.06105801
60STAT1_20625510_ChIP-Seq_HELA_Human1.05452287
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03635770
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.03486585
63IRF1_19129219_ChIP-ChIP_H3396_Human1.03485513
64MAF_26560356_Chip-Seq_TH2_Human1.01695786
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01380172
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00663327
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00533162
68CRX_20693478_ChIP-Seq_RETINA_Mouse0.99957454
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98098772
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97603788
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96995281
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96268120
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96095075
74SPI1_23547873_ChIP-Seq_NB4_Human0.91208403
75SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91190438
76IGF1R_20145208_ChIP-Seq_DFB_Human0.88809484
77ELK1_19687146_ChIP-ChIP_HELA_Human0.87609024
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87505004
79BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86617539
80GABP_19822575_ChIP-Seq_HepG2_Human0.85310437
81CTCF_18555785_Chip-Seq_ESCs_Mouse0.84962483
82MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84604857
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84188446
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83244798
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81395515
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80662979
87TTF2_22483619_ChIP-Seq_HELA_Human0.80548850
88EGR1_19032775_ChIP-ChIP_M12_Human0.80269174
89E2F1_18555785_ChIP-Seq_MESCs_Mouse0.79802147
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79132957
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.79132957
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78468237
93CTCF_20526341_ChIP-Seq_ESCs_Human0.77958897
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75724212
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75710359
96VDR_22108803_ChIP-Seq_LS180_Human0.74238198
97RUNX1_27457419_Chip-Seq_LIVER_Mouse0.73443595
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72918072
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.71614755
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.70836043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.89926676
2MP0005671_abnormal_response_to4.61401765
3MP0001790_abnormal_immune_system4.57660367
4MP0005387_immune_system_phenotype4.57660367
5MP0002933_joint_inflammation4.13699844
6MP0003436_decreased_susceptibility_to4.04970781
7MP0002148_abnormal_hypersensitivity_rea3.42301216
8MP0006082_CNS_inflammation3.24453264
9MP0001835_abnormal_antigen_presentation3.00330681
10MP0008875_abnormal_xenobiotic_pharmacok2.96507267
11MP0001800_abnormal_humoral_immune2.80594907
12MP0001849_ear_inflammation2.78688407
13MP0001853_heart_inflammation2.68804341
14MP0010155_abnormal_intestine_physiology2.66114665
15MP0005000_abnormal_immune_tolerance2.62662759
16MP0002723_abnormal_immune_serum2.36807073
17MP0009333_abnormal_splenocyte_physiolog2.30921966
18MP0005025_abnormal_response_to2.26853634
19MP0001873_stomach_inflammation2.24989098
20MP0002452_abnormal_antigen_presenting2.09356101
21MP0002420_abnormal_adaptive_immunity2.01501981
22MP0001819_abnormal_immune_cell1.98039767
23MP0002277_abnormal_respiratory_mucosa1.97795088
24MP0001533_abnormal_skeleton_physiology1.91597291
25MP0000685_abnormal_immune_system1.81819693
26MP0002095_abnormal_skin_pigmentation1.76762830
27MP0002405_respiratory_system_inflammati1.74125076
28MP0005310_abnormal_salivary_gland1.74117053
29MP0003448_altered_tumor_morphology1.69402424
30MP0003763_abnormal_thymus_physiology1.56672344
31MP0002876_abnormal_thyroid_physiology1.53736587
32MP0001845_abnormal_inflammatory_respons1.48061278
33MP0008873_increased_physiological_sensi1.47822622
34MP0002138_abnormal_hepatobiliary_system1.47395350
35MP0000716_abnormal_immune_system1.47354586
36MP0001243_abnormal_dermal_layer1.45949729
37MP0005187_abnormal_penis_morphology1.32455536
38MP0002722_abnormal_immune_system1.29685262
39MP0003045_fibrosis1.29596967
40MP0004947_skin_inflammation1.28877930
41MP0008469_abnormal_protein_level1.23892931
42MP0008438_abnormal_cutaneous_collagen1.22106443
43MP0002429_abnormal_blood_cell1.20620326
44MP0002419_abnormal_innate_immunity1.18766524
45MP0004145_abnormal_muscle_electrophysio1.18677358
46MP0005584_abnormal_enzyme/coenzyme_acti1.18579014
47MP0002398_abnormal_bone_marrow1.17376545
48MP0002163_abnormal_gland_morphology1.14866470
49MP0001958_emphysema1.12435466
50MP0002998_abnormal_bone_remodeling1.08102626
51MP0005390_skeleton_phenotype1.07761854
52MP0005623_abnormal_meninges_morphology1.07197388
53MP0000703_abnormal_thymus_morphology1.05809827
54MP0005165_increased_susceptibility_to1.05244316
55MP0000689_abnormal_spleen_morphology1.05005272
56MP0000647_abnormal_sebaceous_gland1.03882134
57MP0003866_abnormal_defecation1.01612157
58MP0005319_abnormal_enzyme/_coenzyme0.97928639
59MP0001348_abnormal_lacrimal_gland0.97184921
60MP0000372_irregular_coat_pigmentation0.93628091
61MP0000343_altered_response_to0.93120950
62MP0003724_increased_susceptibility_to0.92614734
63MP0003786_premature_aging0.90776464
64MP0004510_myositis0.88489585
65MP0004134_abnormal_chest_morphology0.87962190
66MP0001765_abnormal_ion_homeostasis0.87636044
67MP0009763_increased_sensitivity_to0.84109843
68MP0003075_altered_response_to0.82433563
69MP0001542_abnormal_bone_strength0.78837193
70MP0001764_abnormal_homeostasis0.76830169
71MP0006036_abnormal_mitochondrial_physio0.76663895
72MP0002090_abnormal_vision0.74442892
73MP0003195_calcinosis0.74118433
74MP0000015_abnormal_ear_pigmentation0.73030125
75MP0002166_altered_tumor_susceptibility0.72256104
76MP0005636_abnormal_mineral_homeostasis0.71157912
77MP0006035_abnormal_mitochondrial_morpho0.69472031
78MP0009764_decreased_sensitivity_to0.69071635
79MP0000490_abnormal_crypts_of0.68572687
80MP0002254_reproductive_system_inflammat0.67303001
81MP0002877_abnormal_melanocyte_morpholog0.63622714
82MP0009765_abnormal_xenobiotic_induced0.62245048
83MP0000627_abnormal_mammary_gland0.62178045
84MP0003252_abnormal_bile_duct0.61280235
85MP0010307_abnormal_tumor_latency0.58656010
86MP0001346_abnormal_lacrimal_gland0.58254247
87MP0003186_abnormal_redox_activity0.56472341
88MP0002006_tumorigenesis0.55929695
89MP0003279_aneurysm0.54954273
90MP0002693_abnormal_pancreas_physiology0.54355216
91MP0001529_abnormal_vocalization0.53781716
92MP0004782_abnormal_surfactant_physiolog0.52459580
93MP0001663_abnormal_digestive_system0.52280180
94MP0005464_abnormal_platelet_physiology0.51882544
95MP0001191_abnormal_skin_condition0.51446697
96MP0003806_abnormal_nucleotide_metabolis0.50009782
97MP0003795_abnormal_bone_structure0.49747510
98MP0001661_extended_life_span0.49474160
99MP0000681_abnormal_thyroid_gland0.48240501
100MP0000604_amyloidosis0.47600442

Predicted human phenotypes

RankGene SetZ-score
1Renal Fanconi syndrome (HP:0001994)5.58859334
2Increased hepatocellular lipid droplets (HP:0006565)5.49260704
3Periodontitis (HP:0000704)5.25973171
4Chronic mucocutaneous candidiasis (HP:0002728)5.01817786
5Recurrent cutaneous fungal infections (HP:0011370)5.01817786
6Lipid accumulation in hepatocytes (HP:0006561)5.01653415
7Increased intramyocellular lipid droplets (HP:0012240)4.90620953
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.65788744
9Decreased activity of mitochondrial respiratory chain (HP:0008972)4.65788744
10Increased muscle lipid content (HP:0009058)4.20246048
11Median cleft lip (HP:0000161)4.16200672
12Abnormality of T cell number (HP:0011839)4.09919657
13T lymphocytopenia (HP:0005403)3.93974609
14Hemoptysis (HP:0002105)3.71087191
15Premature loss of primary teeth (HP:0006323)3.64263859
16Exertional dyspnea (HP:0002875)3.61601261
17Abnormality of T cells (HP:0002843)3.61218909
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.51022388
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.41810340
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.37351161
21Keratoconjunctivitis (HP:0001096)3.35854386
22Abnormality of renal resorption (HP:0011038)3.34090109
23Keratoconjunctivitis sicca (HP:0001097)3.33599902
24Cheilitis (HP:0100825)3.28547579
25IgA deficiency (HP:0002720)3.26322735
26Chronic diarrhea (HP:0002028)3.17648410
27Autoimmune hemolytic anemia (HP:0001890)3.17509922
28Recurrent fungal infections (HP:0002841)3.10167677
29Elevated erythrocyte sedimentation rate (HP:0003565)3.08347693
30Abnormality of T cell physiology (HP:0011840)3.08293097
31Hepatosplenomegaly (HP:0001433)3.04834636
32Autoimmune thrombocytopenia (HP:0001973)3.03527889
33Generalized aminoaciduria (HP:0002909)3.02968564
34Malignant hyperthermia (HP:0002047)3.00512811
35Retrobulbar optic neuritis (HP:0100654)2.99712269
36Optic neuritis (HP:0100653)2.99712269
37Orchitis (HP:0100796)2.96071164
38Mitochondrial inheritance (HP:0001427)2.92178488
39Increased IgM level (HP:0003496)2.85498465
40IgG deficiency (HP:0004315)2.78065223
41Increased CSF lactate (HP:0002490)2.78013307
42Abnormality of the pleura (HP:0002103)2.70542023
43Myositis (HP:0100614)2.68229014
44Pulmonary infiltrates (HP:0002113)2.67675694
45Loss of speech (HP:0002371)2.66668454
4611 pairs of ribs (HP:0000878)2.54206218
47Respiratory difficulties (HP:0002880)2.53548175
48IgM deficiency (HP:0002850)2.47841199
49Abnormality of urine glucose concentration (HP:0011016)2.45756252
50Glycosuria (HP:0003076)2.45756252
51Poor head control (HP:0002421)2.41028857
52Skin rash (HP:0000988)2.40603096
53Stomatitis (HP:0010280)2.40280079
54Lower limb hyperreflexia (HP:0002395)2.36228126
55Meningitis (HP:0001287)2.34537690
56Abnormality of macrophages (HP:0004311)2.34421314
57Hypoproteinemia (HP:0003075)2.33384942
58Joint swelling (HP:0001386)2.31655615
59Encephalitis (HP:0002383)2.31046412
60Porencephaly (HP:0002132)2.30201417
61Acute necrotizing encephalopathy (HP:0006965)2.29910584
62Ureteral stenosis (HP:0000071)2.29735926
63Gangrene (HP:0100758)2.25607533
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.24451795
65Aplastic anemia (HP:0001915)2.23894832
66Abnormality of the prostate (HP:0008775)2.18431913
67Vasculitis (HP:0002633)2.15418192
68Abnormality of eosinophils (HP:0001879)2.15399374
693-Methylglutaconic aciduria (HP:0003535)2.09663061
70Chronic obstructive pulmonary disease (HP:0006510)2.08543955
71Obstructive lung disease (HP:0006536)2.08543955
72Bifid uvula (HP:0000193)2.08484619
73Postaxial foot polydactyly (HP:0001830)2.08351651
74Hyperphosphaturia (HP:0003109)2.08303309
75Ureteral obstruction (HP:0006000)2.05104971
76Progressive inability to walk (HP:0002505)2.03670963
77Mild short stature (HP:0003502)2.03605672
78Episodic fever (HP:0001954)2.02170286
79Increased serum lactate (HP:0002151)2.01051581
80Abnormal mitochondria in muscle tissue (HP:0008316)2.00895537
81Recurrent bronchitis (HP:0002837)2.00655996
82Lactic acidosis (HP:0003128)2.00184278
83Abnormal foot bone ossification (HP:0010675)1.97600115
84Recurrent skin infections (HP:0001581)1.92846315
85Severe combined immunodeficiency (HP:0004430)1.92412077
86Exercise intolerance (HP:0003546)1.91924554
87Abnormality of cells of the lymphoid lineage (HP:0012140)1.90090561
88Increased cerebral lipofuscin (HP:0011813)1.89532042
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89200676
90Abnormal number of incisors (HP:0011064)1.89177030
91Panhypogammaglobulinemia (HP:0003139)1.87726139
92Abnormality of the pericardium (HP:0001697)1.86428652
93Stillbirth (HP:0003826)1.86149144
94Lymphopenia (HP:0001888)1.81168810
95Short tibia (HP:0005736)1.80006182
96Cleft eyelid (HP:0000625)1.79940995
97Carpal bone hypoplasia (HP:0001498)1.79559295
98Recurrent viral infections (HP:0004429)1.79122779
99Progressive macrocephaly (HP:0004481)1.78630070
100Cerebral edema (HP:0002181)1.75375933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.46040783
2NEK14.80079658
3BCKDK4.76862425
4TLK13.03844402
5ACVR1B2.67909562
6WNK42.66594263
7CLK12.62240895
8STK392.60614263
9EIF2AK12.48423702
10KDR2.37444850
11MAP2K62.28327126
12VRK12.28118764
13PRKD32.12240975
14ITK2.12165172
15EIF2AK32.05286312
16OXSR11.98027669
17MAP4K11.69961094
18CSF1R1.69647052
19MST41.63913782
20NME21.53872129
21PIK3CA1.52381966
22IKBKB1.48636988
23JAK31.43919675
24NEK91.42286195
25VRK21.41683858
26TAOK31.41145607
27PRKCH1.33031989
28DAPK31.20588803
29STK161.17758868
30MATK1.12137088
31MYLK1.08723875
32ADRBK21.07641800
33NUAK11.07164684
34LCK1.03491976
35MAP3K141.01465413
36ERN11.00137378
37TYK20.99947914
38SYK0.97342707
39TNK20.91985522
40CCNB10.91873994
41MAP3K130.87795335
42PRKCQ0.84123756
43DAPK10.77395199
44GRK70.75919043
45ZAK0.72523870
46LIMK10.71502350
47MAP3K30.70134324
48CSK0.67129250
49PIK3CG0.66201679
50CAMKK20.65375937
51EPHA40.62791448
52RIPK40.61700617
53NTRK10.61437328
54IKBKE0.57790603
55EPHA30.57668489
56PHKG20.56769973
57PHKG10.56769973
58CHUK0.56203748
59TESK20.55169941
60LYN0.51522476
61AURKA0.51381752
62BCR0.50038052
63ABL20.49938970
64ATR0.49260872
65GRK10.49117023
66PLK30.47686688
67CDK150.47600927
68CDK180.45919295
69JAK10.45733695
70BMPR20.45686475
71PRKCD0.44426181
72MAP3K120.43078809
73CDK11A0.40352900
74KIT0.39962934
75BUB10.39909421
76JAK20.39119090
77PRKG20.38989774
78CAMK2D0.38981425
79FGFR10.37737728
80PRKCE0.36503222
81STK100.36048701
82HIPK20.35256820
83TBK10.34340576
84RPS6KA60.32072814
85CSNK2A10.32018114
86MAPKAPK50.30827471
87ILK0.30520138
88WNK10.30341600
89CDK140.30001460
90PRKCA0.29945887
91MAP4K20.28304274
92RPS6KL10.28282026
93RPS6KC10.28282026
94MAPKAPK30.27919268
95ADRBK10.26990172
96ROCK10.26900599
97MAPKAPK20.26540905
98IGF1R0.26443860
99FYN0.26307585
100TTK0.25798995

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.30183041
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.14298259
3Proteasome_Homo sapiens_hsa030503.88268143
4Autoimmune thyroid disease_Homo sapiens_hsa053203.83657007
5Primary immunodeficiency_Homo sapiens_hsa053403.73878947
6Allograft rejection_Homo sapiens_hsa053303.54445339
7Graft-versus-host disease_Homo sapiens_hsa053323.30695136
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.71221108
9Rheumatoid arthritis_Homo sapiens_hsa053232.57383438
10Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.54136699
11Type I diabetes mellitus_Homo sapiens_hsa049402.53741561
12Protein export_Homo sapiens_hsa030602.53101694
13Oxidative phosphorylation_Homo sapiens_hsa001901.96776692
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.87447976
15Antigen processing and presentation_Homo sapiens_hsa046121.85292661
16Parkinsons disease_Homo sapiens_hsa050121.84661496
17RNA polymerase_Homo sapiens_hsa030201.80663309
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.70740287
19Measles_Homo sapiens_hsa051621.61957313
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42992164
21Hematopoietic cell lineage_Homo sapiens_hsa046401.41677235
22Asthma_Homo sapiens_hsa053101.38422153
23Systemic lupus erythematosus_Homo sapiens_hsa053221.37587803
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32870716
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25807119
26Homologous recombination_Homo sapiens_hsa034401.20591811
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16633360
28Ribosome_Homo sapiens_hsa030101.14055090
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11380382
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11336990
31Huntingtons disease_Homo sapiens_hsa050161.08001504
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07610358
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02731458
34NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99225968
35Pyrimidine metabolism_Homo sapiens_hsa002400.95501625
36Jak-STAT signaling pathway_Homo sapiens_hsa046300.94786242
37Alzheimers disease_Homo sapiens_hsa050100.94653792
38Propanoate metabolism_Homo sapiens_hsa006400.92261865
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91654693
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91436815
41Epstein-Barr virus infection_Homo sapiens_hsa051690.89956179
42Mismatch repair_Homo sapiens_hsa034300.89497980
43DNA replication_Homo sapiens_hsa030300.86448396
44T cell receptor signaling pathway_Homo sapiens_hsa046600.86336761
45Apoptosis_Homo sapiens_hsa042100.81674224
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77076686
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73441984
48Leishmaniasis_Homo sapiens_hsa051400.72634208
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71808335
50Viral myocarditis_Homo sapiens_hsa054160.70105364
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66255800
52Purine metabolism_Homo sapiens_hsa002300.60613252
53One carbon pool by folate_Homo sapiens_hsa006700.59597139
54Peroxisome_Homo sapiens_hsa041460.56932904
55Influenza A_Homo sapiens_hsa051640.56658213
56Folate biosynthesis_Homo sapiens_hsa007900.54210243
57TNF signaling pathway_Homo sapiens_hsa046680.52783073
58Selenocompound metabolism_Homo sapiens_hsa004500.50912783
59Lysosome_Homo sapiens_hsa041420.50687126
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48899167
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.48616754
62Phototransduction_Homo sapiens_hsa047440.47885579
63Fanconi anemia pathway_Homo sapiens_hsa034600.47533995
64Herpes simplex infection_Homo sapiens_hsa051680.47166071
65Collecting duct acid secretion_Homo sapiens_hsa049660.42359997
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.42245425
67Sulfur relay system_Homo sapiens_hsa041220.41690751
68HTLV-I infection_Homo sapiens_hsa051660.41602409
69Salmonella infection_Homo sapiens_hsa051320.41230174
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.39944289
71Cardiac muscle contraction_Homo sapiens_hsa042600.39841280
72Osteoclast differentiation_Homo sapiens_hsa043800.39497287
73Chemokine signaling pathway_Homo sapiens_hsa040620.36516995
74Staphylococcus aureus infection_Homo sapiens_hsa051500.36461712
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35427365
76Nucleotide excision repair_Homo sapiens_hsa034200.34716950
77Toxoplasmosis_Homo sapiens_hsa051450.33752701
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33425229
79Steroid biosynthesis_Homo sapiens_hsa001000.32801152
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31131352
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30276810
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30066358
83RNA degradation_Homo sapiens_hsa030180.29617573
84Pertussis_Homo sapiens_hsa051330.29497542
85Nitrogen metabolism_Homo sapiens_hsa009100.29304780
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28292609
87Hepatitis C_Homo sapiens_hsa051600.28059828
88Metabolic pathways_Homo sapiens_hsa011000.28059319
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25397786
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25219570
91Mineral absorption_Homo sapiens_hsa049780.25016685
92Spliceosome_Homo sapiens_hsa030400.24148590
93Sulfur metabolism_Homo sapiens_hsa009200.23557212
94Alcoholism_Homo sapiens_hsa050340.22958027
95Fatty acid elongation_Homo sapiens_hsa000620.22348473
96African trypanosomiasis_Homo sapiens_hsa051430.22098922
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19108319
98Tuberculosis_Homo sapiens_hsa051520.18968975
99Chemical carcinogenesis_Homo sapiens_hsa052040.15748350
100p53 signaling pathway_Homo sapiens_hsa041150.12745007

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