TIMM50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.57988746
2DNA strand elongation involved in DNA replication (GO:0006271)5.12520540
3ribosomal small subunit assembly (GO:0000028)5.02150264
4telomere maintenance via semi-conservative replication (GO:0032201)4.97322943
5DNA strand elongation (GO:0022616)4.86855062
6DNA replication initiation (GO:0006270)4.74962888
7nucleobase biosynthetic process (GO:0046112)4.71377242
8maturation of SSU-rRNA (GO:0030490)4.61014502
9purine nucleobase biosynthetic process (GO:0009113)4.53646704
10DNA unwinding involved in DNA replication (GO:0006268)4.40554911
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38671582
12formation of translation preinitiation complex (GO:0001731)4.38183764
13viral transcription (GO:0019083)4.31833861
14telomere maintenance via recombination (GO:0000722)4.27362765
15translational termination (GO:0006415)4.23477004
16DNA replication checkpoint (GO:0000076)4.21157078
17proteasome assembly (GO:0043248)4.17548251
18ATP synthesis coupled proton transport (GO:0015986)4.03851628
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.03851628
20deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.00556698
21mitotic recombination (GO:0006312)3.98164871
22translational elongation (GO:0006414)3.97170419
23ribosomal large subunit biogenesis (GO:0042273)3.96732077
24folic acid-containing compound biosynthetic process (GO:0009396)3.88611387
25translational initiation (GO:0006413)3.86325893
26ribosomal small subunit biogenesis (GO:0042274)3.84591595
27telomere maintenance via telomere lengthening (GO:0010833)3.83938268
28ribosome biogenesis (GO:0042254)3.83112965
29ribonucleoprotein complex biogenesis (GO:0022613)3.79414056
30ribosome assembly (GO:0042255)3.77437943
31folic acid metabolic process (GO:0046655)3.75673138
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.70926056
33spliceosomal snRNP assembly (GO:0000387)3.69855810
34IMP biosynthetic process (GO:0006188)3.67423956
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.67292794
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65783403
37CENP-A containing nucleosome assembly (GO:0034080)3.60424937
38chromatin remodeling at centromere (GO:0031055)3.56877211
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.55230737
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.54739518
41cotranslational protein targeting to membrane (GO:0006613)3.54177502
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54153047
43protein targeting to ER (GO:0045047)3.53176819
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52509681
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50951781
46protein localization to kinetochore (GO:0034501)3.50367167
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48124056
48mitochondrial respiratory chain complex assembly (GO:0033108)3.47685866
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.47473294
50NADH dehydrogenase complex assembly (GO:0010257)3.47473294
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47473294
52pseudouridine synthesis (GO:0001522)3.46639738
53rRNA processing (GO:0006364)3.46075790
54mitotic metaphase plate congression (GO:0007080)3.42531619
55protein complex biogenesis (GO:0070271)3.41522295
56water-soluble vitamin biosynthetic process (GO:0042364)3.40102883
57chaperone-mediated protein transport (GO:0072321)3.40076083
58tRNA methylation (GO:0030488)3.38051143
59maturation of 5.8S rRNA (GO:0000460)3.36829843
60DNA replication-dependent nucleosome organization (GO:0034723)3.36816299
61DNA replication-dependent nucleosome assembly (GO:0006335)3.36816299
62mitotic nuclear envelope disassembly (GO:0007077)3.36735079
63negative regulation of ligase activity (GO:0051352)3.36732373
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36732373
65protein localization to endoplasmic reticulum (GO:0070972)3.34783563
66viral life cycle (GO:0019058)3.34314336
67rRNA metabolic process (GO:0016072)3.33652736
68establishment of protein localization to endoplasmic reticulum (GO:0072599)3.33076962
69cellular protein complex disassembly (GO:0043624)3.32941886
70mitochondrial RNA metabolic process (GO:0000959)3.31633051
71translation (GO:0006412)3.27607132
72DNA replication-independent nucleosome assembly (GO:0006336)3.26200032
73DNA replication-independent nucleosome organization (GO:0034724)3.26200032
74regulation of translational fidelity (GO:0006450)3.24964338
75IMP metabolic process (GO:0046040)3.23039000
76viral mRNA export from host cell nucleus (GO:0046784)3.22498377
77regulation of gene silencing by RNA (GO:0060966)3.20072753
78regulation of posttranscriptional gene silencing (GO:0060147)3.20072753
79regulation of gene silencing by miRNA (GO:0060964)3.20072753
80pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.18857272
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.18413981
82transcription-coupled nucleotide-excision repair (GO:0006283)3.17433393
83spliceosomal complex assembly (GO:0000245)3.16985060
84termination of RNA polymerase III transcription (GO:0006386)3.11958586
85transcription elongation from RNA polymerase III promoter (GO:0006385)3.11958586
86UTP biosynthetic process (GO:0006228)3.11359999
87G1/S transition of mitotic cell cycle (GO:0000082)3.10786518
88cell cycle G1/S phase transition (GO:0044843)3.10786518
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10229255
90tRNA modification (GO:0006400)3.07484557
91protein localization to chromosome, centromeric region (GO:0071459)3.07234199
92nuclear envelope disassembly (GO:0051081)3.07017035
93membrane disassembly (GO:0030397)3.07017035
94cellular response to ATP (GO:0071318)3.06714835
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06656595
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06262413
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06262413
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05877177
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05877177
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05877177
101cellular component biogenesis (GO:0044085)3.04981033
102protein complex disassembly (GO:0043241)3.04039221
103peptidyl-histidine modification (GO:0018202)3.04026221
104positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03585996
105signal transduction involved in DNA integrity checkpoint (GO:0072401)3.03014312
106signal transduction involved in DNA damage checkpoint (GO:0072422)3.03014312
107behavioral response to nicotine (GO:0035095)3.02364132
108negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02290458
109kinetochore organization (GO:0051383)3.02274201
110protein K6-linked ubiquitination (GO:0085020)3.02054232
111transcription from mitochondrial promoter (GO:0006390)3.01286654
112rRNA modification (GO:0000154)3.00737491
113regulation of cellular amino acid metabolic process (GO:0006521)3.00104635
114pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.99810844
115signal transduction involved in cell cycle checkpoint (GO:0072395)2.99438774
116GTP biosynthetic process (GO:0006183)2.98897214
117rRNA transcription (GO:0009303)2.98389757
118kinetochore assembly (GO:0051382)2.97431054
119regulation of mitochondrial translation (GO:0070129)2.96329036
120pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.96070000
121pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.95974441
122ncRNA processing (GO:0034470)2.94693560
123respiratory electron transport chain (GO:0022904)2.92643103
124electron transport chain (GO:0022900)2.92534944
125tRNA processing (GO:0008033)2.92029711
126metaphase plate congression (GO:0051310)2.91828969
127L-serine metabolic process (GO:0006563)2.91127027
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91021218
129establishment of integrated proviral latency (GO:0075713)2.90961686
130macromolecular complex disassembly (GO:0032984)2.90339483
131positive regulation of ligase activity (GO:0051351)2.90058010
132replication fork processing (GO:0031297)2.88800745
133nuclear-transcribed mRNA catabolic process (GO:0000956)2.88301100
134deoxyribonucleotide biosynthetic process (GO:0009263)2.87335732
135CTP biosynthetic process (GO:0006241)2.86373328
136CTP metabolic process (GO:0046036)2.86373328
137* protein targeting to mitochondrion (GO:0006626)2.85887988
138pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.85141813
139histone exchange (GO:0043486)2.84246548
140negative regulation of RNA splicing (GO:0033119)2.84218115
141heterochromatin organization (GO:0070828)2.83895772
142pteridine-containing compound biosynthetic process (GO:0042559)2.82141367
143ncRNA metabolic process (GO:0034660)2.79480850
144regulation of DNA endoreduplication (GO:0032875)2.78228662
145UTP metabolic process (GO:0046051)2.76627394
146* establishment of protein localization to mitochondrion (GO:0072655)2.73686986
147negative regulation of DNA-templated transcription, elongation (GO:0032785)2.73212666
148pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.71282291
149tRNA metabolic process (GO:0006399)2.69811182
150histone arginine methylation (GO:0034969)2.68498018
151ribonucleoside triphosphate biosynthetic process (GO:0009201)2.66960834
152somatic diversification of immune receptors via somatic mutation (GO:0002566)2.65538550
153somatic hypermutation of immunoglobulin genes (GO:0016446)2.65538550
154purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.64146265
155RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.63426324
156positive regulation of fatty acid beta-oxidation (GO:0032000)2.62856365
157purine nucleoside triphosphate biosynthetic process (GO:0009145)2.62482382
158RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62199609
159tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62199609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.21836228
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.31171036
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.28447788
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33370268
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.14176248
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10738008
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04414778
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02473959
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.99475172
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.97998835
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.90133595
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87559915
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80053287
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78890085
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75594468
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51968080
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46534128
18XRN2_22483619_ChIP-Seq_HELA_Human2.44038403
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29416131
20VDR_23849224_ChIP-Seq_CD4+_Human2.19213788
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12346881
22DCP1A_22483619_ChIP-Seq_HELA_Human2.10337489
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10291623
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03707096
25GABP_19822575_ChIP-Seq_HepG2_Human2.00459556
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96756211
27FOXP3_21729870_ChIP-Seq_TREG_Human1.94014936
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93977573
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89390945
30AR_21909140_ChIP-Seq_LNCAP_Human1.87515845
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84081663
32TTF2_22483619_ChIP-Seq_HELA_Human1.82859775
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78441697
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.76097376
35CIITA_25753668_ChIP-Seq_RAJI_Human1.75600240
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74748067
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74233538
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.72993404
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71240075
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67987385
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67869029
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67336095
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65417285
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63400288
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.61642994
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61603818
47MYC_22102868_ChIP-Seq_BL_Human1.59944133
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59693084
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55537948
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52244766
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49005921
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46566689
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42834277
54* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41732734
55* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39741986
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38937677
57* KDM5A_27292631_Chip-Seq_BREAST_Human1.38195129
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35252768
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34594186
60ELK1_19687146_ChIP-ChIP_HELA_Human1.32214056
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31333673
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29156672
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28245843
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24754138
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23571974
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.23454067
67VDR_21846776_ChIP-Seq_THP-1_Human1.23330118
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21918090
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19952872
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19739710
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19512866
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19316283
73P68_20966046_ChIP-Seq_HELA_Human1.16453627
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15939071
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14338147
76* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12742794
77* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11843542
78TFEB_21752829_ChIP-Seq_HELA_Human1.10624913
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10542244
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10453939
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08727791
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08499147
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05759562
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05179410
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03647516
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.01310108
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99847158
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98075830
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97808628
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97770390
91SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96982761
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.95675551
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95165859
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95034067
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94651330
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94034568
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93816488
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92764433
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92180706
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92146551
101* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91754728
102MYC_18940864_ChIP-ChIP_HL60_Human0.91312800
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90412878
104PHF8_20622854_ChIP-Seq_HELA_Human0.90372038
105NANOG_16153702_ChIP-ChIP_HESCs_Human0.89724652
106IRF1_19129219_ChIP-ChIP_H3396_Human0.89510966
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89276160
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.89198255
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88829490
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87094318
111ZNF263_19887448_ChIP-Seq_K562_Human0.86904419
112* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86643506
113* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86425258
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.86391945
115POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85867621
116SPI1_23547873_ChIP-Seq_NB4_Human0.85588738
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.84864720
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83099977
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82702726
120* FOXP1_21924763_ChIP-Seq_HESCs_Human0.82173115
121CTCF_20526341_ChIP-Seq_ESCs_Human0.81538657
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.80951769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.50903251
2MP0004957_abnormal_blastocyst_morpholog4.48368340
3MP0003111_abnormal_nucleus_morphology4.44270886
4MP0010094_abnormal_chromosome_stability4.39081402
5MP0003077_abnormal_cell_cycle3.89946603
6MP0008058_abnormal_DNA_repair3.22089202
7MP0008057_abnormal_DNA_replication3.07207265
8MP0008932_abnormal_embryonic_tissue2.67537382
9MP0008007_abnormal_cellular_replicative2.66819413
10MP0002396_abnormal_hematopoietic_system2.60310666
11MP0006292_abnormal_olfactory_placode2.59912856
12MP0004185_abnormal_adipocyte_glucose2.44435828
13MP0003806_abnormal_nucleotide_metabolis2.38792290
14MP0000049_abnormal_middle_ear2.31928736
15MP0000678_abnormal_parathyroid_gland2.30346759
16MP0001730_embryonic_growth_arrest2.26841700
17MP0003123_paternal_imprinting2.14953774
18MP0000350_abnormal_cell_proliferation2.06147196
19MP0003786_premature_aging2.00288800
20MP0000490_abnormal_crypts_of1.92480813
21MP0002249_abnormal_larynx_morphology1.76428308
22MP0003718_maternal_effect1.71003069
23MP0009333_abnormal_splenocyte_physiolog1.68134787
24MP0003937_abnormal_limbs/digits/tail_de1.64640134
25MP0003186_abnormal_redox_activity1.64307651
26MP0006036_abnormal_mitochondrial_physio1.62319912
27MP0001697_abnormal_embryo_size1.61760370
28MP0002163_abnormal_gland_morphology1.60946903
29MP0002080_prenatal_lethality1.59827373
30MP0000372_irregular_coat_pigmentation1.57746662
31MP0001672_abnormal_embryogenesis/_devel1.57579832
32MP0005380_embryogenesis_phenotype1.57579832
33MP0009840_abnormal_foam_cell1.55556564
34MP0010030_abnormal_orbit_morphology1.52412497
35MP0000313_abnormal_cell_death1.52335437
36MP0002019_abnormal_tumor_incidence1.50547130
37MP0003984_embryonic_growth_retardation1.45453948
38MP0003136_yellow_coat_color1.45340968
39MP0002088_abnormal_embryonic_growth/wei1.41911869
40MP0009250_abnormal_appendicular_skeleto1.41391348
41MP0010352_gastrointestinal_tract_polyps1.41001572
42MP0003315_abnormal_perineum_morphology1.40749636
43MP0002234_abnormal_pharynx_morphology1.39874369
44MP0005646_abnormal_pituitary_gland1.38811958
45MP0005397_hematopoietic_system_phenotyp1.36863255
46MP0001545_abnormal_hematopoietic_system1.36863255
47MP0003567_abnormal_fetal_cardiomyocyte1.35252551
48MP0010307_abnormal_tumor_latency1.35229930
49MP0006035_abnormal_mitochondrial_morpho1.34097539
50MP0005670_abnormal_white_adipose1.33188783
51MP0003656_abnormal_erythrocyte_physiolo1.30654139
52MP0000358_abnormal_cell_content/1.30328536
53MP0002085_abnormal_embryonic_tissue1.29675670
54MP0000631_abnormal_neuroendocrine_gland1.26745549
55MP0002837_dystrophic_cardiac_calcinosis1.26611751
56MP0004145_abnormal_muscle_electrophysio1.26490136
57MP0004808_abnormal_hematopoietic_stem1.26016372
58MP0002132_abnormal_respiratory_system1.20079998
59MP0001188_hyperpigmentation1.18716024
60MP0003938_abnormal_ear_development1.17462724
61MP0006054_spinal_hemorrhage1.15127386
62MP0004134_abnormal_chest_morphology1.15030545
63MP0002722_abnormal_immune_system1.13626629
64MP0002653_abnormal_ependyma_morphology1.13420844
65MP0001485_abnormal_pinna_reflex1.13232567
66MP0003942_abnormal_urinary_system1.12960041
67MP0000703_abnormal_thymus_morphology1.12236296
68MP0003221_abnormal_cardiomyocyte_apopto1.12076795
69MP0004147_increased_porphyrin_level1.11758010
70MP0001853_heart_inflammation1.11226211
71MP0008872_abnormal_physiological_respon1.10892005
72MP0005083_abnormal_biliary_tract1.09941317
73MP0002086_abnormal_extraembryonic_tissu1.08696702
74MP0004197_abnormal_fetal_growth/weight/1.08503053
75MP0000689_abnormal_spleen_morphology1.08069417
76MP0008877_abnormal_DNA_methylation1.06450218
77MP0003763_abnormal_thymus_physiology1.05394943
78MP0001968_abnormal_touch/_nociception1.04595366
79MP0002084_abnormal_developmental_patter1.03268293
80MP0005075_abnormal_melanosome_morpholog1.02815499
81MP0002398_abnormal_bone_marrow1.00770504
82MP0000537_abnormal_urethra_morphology1.00760885
83MP0001764_abnormal_homeostasis0.97631116
84MP0002210_abnormal_sex_determination0.96876994
85MP0001346_abnormal_lacrimal_gland0.96119471
86MP0005645_abnormal_hypothalamus_physiol0.94651477
87MP0004233_abnormal_muscle_weight0.94167533
88MP0000750_abnormal_muscle_regeneration0.92219509
89MP0002102_abnormal_ear_morphology0.91509940
90MP0001661_extended_life_span0.91373760
91MP0001293_anophthalmia0.90034720
92MP0001145_abnormal_male_reproductive0.89644592
93MP0009672_abnormal_birth_weight0.88852405
94MP0004130_abnormal_muscle_cell0.88820413
95MP0002429_abnormal_blood_cell0.88352618
96MP0002736_abnormal_nociception_after0.86664092
97MP0009046_muscle_twitch0.85264170
98MP0003646_muscle_fatigue0.83649294
99MP0002160_abnormal_reproductive_system0.83130942
100MP0000858_altered_metastatic_potential0.80354200
101MP0003861_abnormal_nervous_system0.79380379
102MP0003119_abnormal_digestive_system0.77286088
103MP0005187_abnormal_penis_morphology0.76949454
104MP0009379_abnormal_foot_pigmentation0.76489574
105MP0005330_cardiomyopathy0.76314628
106MP0005379_endocrine/exocrine_gland_phen0.75181265
107MP0000003_abnormal_adipose_tissue0.75126345
108MP0002733_abnormal_thermal_nociception0.75076057
109MP0009053_abnormal_anal_canal0.74472939
110MP0002177_abnormal_outer_ear0.74451021
111MP0001286_abnormal_eye_development0.74045533
112MP0000598_abnormal_liver_morphology0.73311173
113MP0005384_cellular_phenotype0.73147114
114MP0002932_abnormal_joint_morphology0.72974058
115MP0000762_abnormal_tongue_morphology0.72928875
116MP0002111_abnormal_tail_morphology0.72403697
117MP0002697_abnormal_eye_size0.72272271
118MP0003890_abnormal_embryonic-extraembry0.72037568
119MP0005266_abnormal_metabolism0.71634186
120MP0000653_abnormal_sex_gland0.71177308
121MP0002269_muscular_atrophy0.71086866
122MP0001873_stomach_inflammation0.70939163
123MP0001119_abnormal_female_reproductive0.70311084
124MP0002735_abnormal_chemical_nociception0.70038622
125MP0005389_reproductive_system_phenotype0.69034872
126MP0002184_abnormal_innervation0.68579836
127MP0006072_abnormal_retinal_apoptosis0.68065275
128MP0005174_abnormal_tail_pigmentation0.67474074
129MP0004084_abnormal_cardiac_muscle0.66579910
130MP0005551_abnormal_eye_electrophysiolog0.65916322
131MP0001929_abnormal_gametogenesis0.65908516
132MP0000477_abnormal_intestine_morphology0.65889650
133MP0003698_abnormal_male_reproductive0.65240353
134MP0003755_abnormal_palate_morphology0.64645776
135MP0000716_abnormal_immune_system0.63652909
136MP0005319_abnormal_enzyme/_coenzyme0.61251001
137MP0001919_abnormal_reproductive_system0.59539209
138MP0005621_abnormal_cell_physiology0.57431555
139MP0004133_heterotaxia0.57293485
140MP0002089_abnormal_postnatal_growth/wei0.54895957
141MP0005023_abnormal_wound_healing0.54188627
142MP0008789_abnormal_olfactory_epithelium0.54111584
143MP0001915_intracranial_hemorrhage0.53899809
144MP0008260_abnormal_autophagy0.53518949
145MP0009278_abnormal_bone_marrow0.50524796
146MP0002970_abnormal_white_adipose0.50131122
147MP0002938_white_spotting0.48445218
148MP0001727_abnormal_embryo_implantation0.48147406
149MP0002139_abnormal_hepatobiliary_system0.47915261
150MP0003121_genomic_imprinting0.47040054
151MP0008873_increased_physiological_sensi0.45996806

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.03025600
2Abnormal number of erythroid precursors (HP:0012131)4.96300821
3Reticulocytopenia (HP:0001896)4.64042294
4Birth length less than 3rd percentile (HP:0003561)4.27375035
5Oral leukoplakia (HP:0002745)3.95870823
6Breast hypoplasia (HP:0003187)3.84064582
7Macrocytic anemia (HP:0001972)3.43903826
8Pendular nystagmus (HP:0012043)3.43276793
9Microretrognathia (HP:0000308)3.33527795
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.29722626
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.29722626
12Aplastic anemia (HP:0001915)3.26857467
13Cerebral hypomyelination (HP:0006808)3.14488734
14Increased serum lactate (HP:0002151)3.14323385
15Abnormality of the anterior horn cell (HP:0006802)3.13908546
16Degeneration of anterior horn cells (HP:0002398)3.13908546
17Pallor (HP:0000980)3.12151092
18Rough bone trabeculation (HP:0100670)3.09693393
19Multiple enchondromatosis (HP:0005701)3.06975698
20Hepatic necrosis (HP:0002605)3.02105614
21Hepatocellular necrosis (HP:0001404)2.99731795
22Carpal bone hypoplasia (HP:0001498)2.92526111
23Patellar aplasia (HP:0006443)2.90650967
24Aplasia/Hypoplasia of the patella (HP:0006498)2.86441300
25Selective tooth agenesis (HP:0001592)2.82422847
26Colon cancer (HP:0003003)2.79282136
27Progressive muscle weakness (HP:0003323)2.77587917
28Abnormality of alanine metabolism (HP:0010916)2.68522122
29Hyperalaninemia (HP:0003348)2.68522122
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68522122
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58043071
32Increased CSF lactate (HP:0002490)2.56027348
333-Methylglutaconic aciduria (HP:0003535)2.54813197
34Trismus (HP:0000211)2.53596543
35Abnormality of cochlea (HP:0000375)2.52647312
36Methylmalonic aciduria (HP:0012120)2.52124950
37Abnormality of the preputium (HP:0100587)2.47820120
38Increased hepatocellular lipid droplets (HP:0006565)2.47734296
39Abnormality of the heme biosynthetic pathway (HP:0010472)2.44856509
40Increased intramyocellular lipid droplets (HP:0012240)2.43841669
41Lipid accumulation in hepatocytes (HP:0006561)2.43475587
42Abnormality of DNA repair (HP:0003254)2.42965890
43Absent thumb (HP:0009777)2.41993270
44Mitochondrial inheritance (HP:0001427)2.40140375
45Megaloblastic anemia (HP:0001889)2.38684174
46Meckel diverticulum (HP:0002245)2.38668877
47Increased muscle lipid content (HP:0009058)2.37142932
48Abnormality of glycolysis (HP:0004366)2.37041964
49Increased serum pyruvate (HP:0003542)2.37041964
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34509323
51Hypoplastic pelvis (HP:0008839)2.33835610
52Type I transferrin isoform profile (HP:0003642)2.33754836
53Cleft eyelid (HP:0000625)2.30760168
54Abnormality of the ileum (HP:0001549)2.30660833
55Premature graying of hair (HP:0002216)2.27714500
56Lactic acidosis (HP:0003128)2.27588099
57Progressive macrocephaly (HP:0004481)2.27347195
58Abnormality of pyrimidine metabolism (HP:0004353)2.27197096
59Pancytopenia (HP:0001876)2.26732743
60Thrombocytosis (HP:0001894)2.26433675
61Neoplasm of the pancreas (HP:0002894)2.26388597
62Abnormality of homocysteine metabolism (HP:0010919)2.23581314
63Homocystinuria (HP:0002156)2.23581314
64Exertional dyspnea (HP:0002875)2.23426605
65Chromsome breakage (HP:0040012)2.23155496
66Concave nail (HP:0001598)2.22236160
67Sclerocornea (HP:0000647)2.21760945
68Premature ovarian failure (HP:0008209)2.21022050
69Pancreatic cysts (HP:0001737)2.18398049
70Abnormality of reticulocytes (HP:0004312)2.18270928
71Secondary amenorrhea (HP:0000869)2.15072696
72Hypoplasia of the pons (HP:0012110)2.14617161
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14445208
74Respiratory difficulties (HP:0002880)2.13612184
75Abnormality of chromosome stability (HP:0003220)2.13180472
76Abnormal trabecular bone morphology (HP:0100671)2.13179879
77Cellular immunodeficiency (HP:0005374)2.13029306
78Pancreatic fibrosis (HP:0100732)2.11625816
79Abnormal mitochondria in muscle tissue (HP:0008316)2.11114549
80Nausea (HP:0002018)2.10885743
81Large for gestational age (HP:0001520)2.10129361
82Methylmalonic acidemia (HP:0002912)2.08709295
83Poor head control (HP:0002421)2.08411414
8411 pairs of ribs (HP:0000878)2.08389420
85Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08272563
86CNS demyelination (HP:0007305)2.08228490
87Confusion (HP:0001289)2.07745121
88Horseshoe kidney (HP:0000085)2.07497565
89Microvesicular hepatic steatosis (HP:0001414)2.06407152
90Hypoplasia of the uterus (HP:0000013)2.06053547
91Tinnitus (HP:0000360)2.05793067
92Bone marrow hypocellularity (HP:0005528)2.05720250
93Morphological abnormality of the inner ear (HP:0011390)2.05094598
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04099312
95Rhabdomyolysis (HP:0003201)2.04007443
96Impulsivity (HP:0100710)2.03441015
97Medulloblastoma (HP:0002885)2.03368728
98Short thumb (HP:0009778)2.02534461
99Ependymoma (HP:0002888)2.00990484
100Abnormality of the renal collecting system (HP:0004742)2.00391689
101Sparse eyelashes (HP:0000653)1.99884780
102Myelodysplasia (HP:0002863)1.98606180
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.98511273
104Bilateral microphthalmos (HP:0007633)1.97238150
105Acute necrotizing encephalopathy (HP:0006965)1.96555817
106Atrophy/Degeneration involving motor neurons (HP:0007373)1.96386776
107Genetic anticipation (HP:0003743)1.95280019
108Abnormality of the pons (HP:0007361)1.95188674
109Exercise intolerance (HP:0003546)1.94814858
110Aplasia/hypoplasia of the uterus (HP:0008684)1.94237539
111Absent radius (HP:0003974)1.94016978
112Squamous cell carcinoma (HP:0002860)1.93898969
113Ragged-red muscle fibers (HP:0003200)1.92249587
114Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90507085
115Reduced antithrombin III activity (HP:0001976)1.89986967
116Cerebral edema (HP:0002181)1.89888864
117Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89813856
118Dicarboxylic aciduria (HP:0003215)1.89813856
119Duodenal stenosis (HP:0100867)1.89721861
120Small intestinal stenosis (HP:0012848)1.89721861
121Emotional lability (HP:0000712)1.88582491
122Abnormality of subcutaneous fat tissue (HP:0001001)1.87616274
123Petechiae (HP:0000967)1.87344827
124IgM deficiency (HP:0002850)1.86872450
125Renal Fanconi syndrome (HP:0001994)1.86395342
126Hypoplasia of the radius (HP:0002984)1.84777664
127Severe visual impairment (HP:0001141)1.84723551
128Abnormal number of incisors (HP:0011064)1.83222614
129Abnormality of the carotid arteries (HP:0005344)1.83092671
130Acute encephalopathy (HP:0006846)1.82973486
131Molar tooth sign on MRI (HP:0002419)1.82839563
132Abnormality of midbrain morphology (HP:0002418)1.82839563
133Renal agenesis (HP:0000104)1.82560411
134Tracheoesophageal fistula (HP:0002575)1.81200819
135Unsteady gait (HP:0002317)1.80174767
136Absent forearm bone (HP:0003953)1.78888756
137Aplasia involving forearm bones (HP:0009822)1.78888756
138Abnormality of the proximal phalanges of the hand (HP:0009834)1.77531167
139Triphalangeal thumb (HP:0001199)1.77522361
140Congenital stationary night blindness (HP:0007642)1.76652899
141Unilateral renal agenesis (HP:0000122)1.73534121
142Fibular aplasia (HP:0002990)1.71944611
143Conjunctival hamartoma (HP:0100780)1.71222895
144Truncus arteriosus (HP:0001660)1.71076580
145Asplenia (HP:0001746)1.68113288
146Visual hallucinations (HP:0002367)1.67607080
147True hermaphroditism (HP:0010459)1.67029921
148Aplasia/Hypoplasia of the spleen (HP:0010451)1.67023047
149Severe muscular hypotonia (HP:0006829)1.66524658
150Patent foramen ovale (HP:0001655)1.65435485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.36868059
2VRK24.15946787
3WEE13.95555971
4EIF2AK13.45397307
5CDC73.34857172
6STK163.20657320
7NME23.17246130
8NEK12.65274206
9TESK22.46923656
10TLK12.35713522
11NEK22.32696761
12SRPK12.12927357
13ACVR1B2.06387254
14BCKDK1.99118982
15TSSK61.97916807
16VRK11.97658036
17PLK41.97600721
18SMG11.91407006
19EIF2AK31.88392636
20WNK41.80881086
21TTK1.75950905
22KDR1.73334708
23PLK11.66860014
24DYRK31.66774582
25BRSK21.63271465
26SCYL21.56666115
27PBK1.53015630
28CCNB11.53011696
29NUAK11.51184168
30RPS6KA41.50779253
31CDK71.50678671
32BRSK11.47322539
33TAF11.47069166
34AURKB1.46540287
35PASK1.46129804
36PIM21.44690693
37ADRBK21.44630090
38GRK11.39816969
39AURKA1.37101055
40ATR1.29708129
41MAP3K101.28470029
42RPS6KB21.26822064
43MKNK11.24299004
44TGFBR11.20456248
45MAP3K81.19492988
46MAP3K111.17972801
47CSNK1G31.15913973
48PAK41.14900093
49CDK41.11848298
50CHEK21.08181416
51ZAK1.07093347
52EPHA21.06761183
53EEF2K1.02821583
54CSNK1A1L1.01377345
55TESK10.97880694
56ICK0.93269590
57TRIB30.92845719
58MAP4K10.92767395
59FLT30.92204950
60PLK30.89785955
61MAP2K30.88856688
62CSNK1G10.88131822
63LRRK20.88102680
64CDK90.87979771
65PKN20.87380045
66BMPR1B0.86733598
67STK390.84927824
68PHKG10.79980145
69PHKG20.79980145
70MAP3K90.79977427
71STK100.79857655
72TAOK20.79773504
73NME10.79455181
74CHEK10.79177237
75MAPKAPK30.77331240
76CSNK1G20.76606871
77PAK10.75773769
78BRAF0.71982643
79ILK0.70144243
80STK40.70086187
81PIM10.68637758
82PRKD20.66469686
83CSNK2A10.65660090
84PDK20.63445355
85EIF2AK20.62032642
86CSNK2A20.61420328
87ZAP700.61322565
88MAPKAPK50.59554145
89CDK20.59307455
90MKNK20.58435730
91ERBB40.56919648
92CDK80.56543977
93FRK0.55542632
94PINK10.53459774
95DYRK20.48977287
96PRKCI0.47493109
97IRAK30.47256576
98CSNK1E0.46999431
99MAPK110.46610106
100ARAF0.46447611
101PKN10.46233988
102BLK0.45394281
103ATM0.45081959
104MELK0.44574479
105ERN10.44333042
106RPS6KA50.44164112
107AKT20.43658136
108MST1R0.43652314
109CSNK1A10.43223049
110CDK190.43217852
111BTK0.41935570
112ABL20.39522162
113PDK30.38748877
114PDK40.38748877
115MAP2K20.37898508
116CDK10.36960023
117INSRR0.36054284
118MAP3K30.35291581
119MAP2K70.34085022
120LIMK10.33133889
121LMTK20.32234752
122PRKDC0.28724876
123TYK20.27786111
124CDK11A0.27260816
125GRK60.25503197
126DAPK10.24171630
127RPS6KC10.21701535
128RPS6KL10.21701535
129CSF1R0.21456571
130RPS6KA10.20965555
131RAF10.19932962
132RPS6KA60.19908491
133MAP2K60.19792740
134DAPK30.18527499
135MAPK40.16325128
136CDK60.15883394

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.00878096
2Mismatch repair_Homo sapiens_hsa034303.90792838
3Ribosome_Homo sapiens_hsa030103.87215732
4Proteasome_Homo sapiens_hsa030503.76644777
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.15720735
6Spliceosome_Homo sapiens_hsa030403.11287508
7RNA polymerase_Homo sapiens_hsa030203.10966879
8Base excision repair_Homo sapiens_hsa034103.01658657
9Homologous recombination_Homo sapiens_hsa034402.74938525
10Pyrimidine metabolism_Homo sapiens_hsa002402.70006409
11RNA transport_Homo sapiens_hsa030132.61916156
12One carbon pool by folate_Homo sapiens_hsa006702.61496599
13Nucleotide excision repair_Homo sapiens_hsa034202.59610506
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22802478
15Cell cycle_Homo sapiens_hsa041102.18666904
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.90941004
17Fanconi anemia pathway_Homo sapiens_hsa034601.67508792
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55938786
19Folate biosynthesis_Homo sapiens_hsa007901.55277912
20RNA degradation_Homo sapiens_hsa030181.52456834
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52068763
22Sulfur relay system_Homo sapiens_hsa041221.48956679
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.41457502
24Non-homologous end-joining_Homo sapiens_hsa034501.41355947
25Biosynthesis of amino acids_Homo sapiens_hsa012301.38367702
26Pentose phosphate pathway_Homo sapiens_hsa000301.36300352
27Purine metabolism_Homo sapiens_hsa002301.35943513
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.26692614
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.26424326
30p53 signaling pathway_Homo sapiens_hsa041151.26118212
31Basal transcription factors_Homo sapiens_hsa030221.25455058
32Carbon metabolism_Homo sapiens_hsa012001.25072188
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17802394
34Parkinsons disease_Homo sapiens_hsa050121.14741282
35Sulfur metabolism_Homo sapiens_hsa009201.12127894
36mRNA surveillance pathway_Homo sapiens_hsa030151.05964661
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05758934
38Selenocompound metabolism_Homo sapiens_hsa004501.04086315
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02923464
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01156327
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98814823
42Huntingtons disease_Homo sapiens_hsa050160.95206557
43Epstein-Barr virus infection_Homo sapiens_hsa051690.92866299
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91810424
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91723417
46Oxidative phosphorylation_Homo sapiens_hsa001900.90624475
47Systemic lupus erythematosus_Homo sapiens_hsa053220.89798966
48Glutathione metabolism_Homo sapiens_hsa004800.83243130
49Vitamin B6 metabolism_Homo sapiens_hsa007500.79436791
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78945633
51Phototransduction_Homo sapiens_hsa047440.77366177
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76125400
53Protein export_Homo sapiens_hsa030600.75103868
54Basal cell carcinoma_Homo sapiens_hsa052170.74663912
55Fructose and mannose metabolism_Homo sapiens_hsa000510.73547384
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70183233
57Melanoma_Homo sapiens_hsa052180.67439892
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.63342603
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62477566
60Herpes simplex infection_Homo sapiens_hsa051680.60937602
61N-Glycan biosynthesis_Homo sapiens_hsa005100.60673078
62Fatty acid elongation_Homo sapiens_hsa000620.59717803
63Galactose metabolism_Homo sapiens_hsa000520.59674737
64Antigen processing and presentation_Homo sapiens_hsa046120.59041739
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57725523
66Viral carcinogenesis_Homo sapiens_hsa052030.54836684
67Pyruvate metabolism_Homo sapiens_hsa006200.54105928
68Nitrogen metabolism_Homo sapiens_hsa009100.53245240
69Nicotine addiction_Homo sapiens_hsa050330.52272799
70Oocyte meiosis_Homo sapiens_hsa041140.51867679
71Hedgehog signaling pathway_Homo sapiens_hsa043400.51415616
72Metabolic pathways_Homo sapiens_hsa011000.50788112
73HTLV-I infection_Homo sapiens_hsa051660.50582037
74Legionellosis_Homo sapiens_hsa051340.48936652
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48172361
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46859344
77Tryptophan metabolism_Homo sapiens_hsa003800.46090465
78Propanoate metabolism_Homo sapiens_hsa006400.44602921
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44154087
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44118993
81Arginine and proline metabolism_Homo sapiens_hsa003300.43211138
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42329829
83Thyroid cancer_Homo sapiens_hsa052160.37855171
84Hippo signaling pathway_Homo sapiens_hsa043900.37674712
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37530915
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36863199
87Alzheimers disease_Homo sapiens_hsa050100.36088454
88Fatty acid degradation_Homo sapiens_hsa000710.35849453
89Primary immunodeficiency_Homo sapiens_hsa053400.29400581
90beta-Alanine metabolism_Homo sapiens_hsa004100.28562962
91Apoptosis_Homo sapiens_hsa042100.28532890
92Wnt signaling pathway_Homo sapiens_hsa043100.25788278
93Lysine degradation_Homo sapiens_hsa003100.25592765
94Steroid biosynthesis_Homo sapiens_hsa001000.23976365
95Shigellosis_Homo sapiens_hsa051310.23866632
96Peroxisome_Homo sapiens_hsa041460.22525893
97Small cell lung cancer_Homo sapiens_hsa052220.22043998
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19342189
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19070862
100Bladder cancer_Homo sapiens_hsa052190.18853856
101Regulation of autophagy_Homo sapiens_hsa041400.18588690
102Chemical carcinogenesis_Homo sapiens_hsa052040.18249489
103Notch signaling pathway_Homo sapiens_hsa043300.17754698
104Renin-angiotensin system_Homo sapiens_hsa046140.16959595
105Glycerolipid metabolism_Homo sapiens_hsa005610.16153900
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15719463
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.15333156
108Taste transduction_Homo sapiens_hsa047420.13573062
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13410770
110Vitamin digestion and absorption_Homo sapiens_hsa049770.12558189
111Fatty acid biosynthesis_Homo sapiens_hsa000610.11808670
112Fat digestion and absorption_Homo sapiens_hsa049750.11802858
113Phenylalanine metabolism_Homo sapiens_hsa003600.11442055
114HIF-1 signaling pathway_Homo sapiens_hsa040660.11403562
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10822658
116Fatty acid metabolism_Homo sapiens_hsa012120.10660367
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10303836
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09998400
119Synaptic vesicle cycle_Homo sapiens_hsa047210.09949165
120Tyrosine metabolism_Homo sapiens_hsa003500.09746127
121Cardiac muscle contraction_Homo sapiens_hsa042600.09669707
122Morphine addiction_Homo sapiens_hsa050320.09050892
123Measles_Homo sapiens_hsa051620.08694411
124Hepatitis B_Homo sapiens_hsa051610.08521054
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08369054
126Alcoholism_Homo sapiens_hsa050340.07856939
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07170024
128MicroRNAs in cancer_Homo sapiens_hsa052060.06730693

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