TIMM23B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.59119076
2DNA double-strand break processing (GO:0000729)4.02961931
3DNA deamination (GO:0045006)3.83426819
4fucose catabolic process (GO:0019317)3.69817184
5L-fucose metabolic process (GO:0042354)3.69817184
6L-fucose catabolic process (GO:0042355)3.69817184
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.60809527
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.56991456
9regulation of translation, ncRNA-mediated (GO:0045974)3.56991456
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.56991456
11centriole replication (GO:0007099)3.46288077
12respiratory chain complex IV assembly (GO:0008535)3.42669852
13protein complex biogenesis (GO:0070271)3.37631336
14water-soluble vitamin biosynthetic process (GO:0042364)3.37415899
15replication fork processing (GO:0031297)3.36748662
16regulation of hexokinase activity (GO:1903299)3.35667236
17regulation of glucokinase activity (GO:0033131)3.35667236
18NADH dehydrogenase complex assembly (GO:0010257)3.33957377
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33957377
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.33957377
21recombinational repair (GO:0000725)3.27886987
22double-strand break repair via homologous recombination (GO:0000724)3.26084126
23neural tube formation (GO:0001841)3.25174749
24mitochondrial respiratory chain complex assembly (GO:0033108)3.17098676
25detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16849712
26epithelial cilium movement (GO:0003351)3.14046276
27indole-containing compound catabolic process (GO:0042436)3.13419215
28indolalkylamine catabolic process (GO:0046218)3.13419215
29tryptophan catabolic process (GO:0006569)3.13419215
30peptidyl-histidine modification (GO:0018202)3.12848348
31protein-cofactor linkage (GO:0018065)3.11147305
32protein prenylation (GO:0018342)3.10945113
33prenylation (GO:0097354)3.10945113
34protein K11-linked deubiquitination (GO:0035871)3.10860882
35protein K6-linked ubiquitination (GO:0085020)3.08633447
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.03019539
37cytochrome complex assembly (GO:0017004)3.01980100
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01576507
39synapsis (GO:0007129)3.00967034
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98083881
41regulation of mitotic spindle checkpoint (GO:1903504)2.98083881
42neuron fate determination (GO:0048664)2.97318091
43indolalkylamine metabolic process (GO:0006586)2.91406749
44preassembly of GPI anchor in ER membrane (GO:0016254)2.89622840
45kidney morphogenesis (GO:0060993)2.89285506
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88672661
47kynurenine metabolic process (GO:0070189)2.87538414
48pseudouridine synthesis (GO:0001522)2.85562476
49tryptophan metabolic process (GO:0006568)2.84024200
50cilium morphogenesis (GO:0060271)2.81206780
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79997930
52RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79764721
53reciprocal DNA recombination (GO:0035825)2.79637329
54reciprocal meiotic recombination (GO:0007131)2.79637329
55negative regulation of DNA-dependent DNA replication (GO:2000104)2.78298010
56energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77998791
57ATP synthesis coupled proton transport (GO:0015986)2.77998791
58cellular ketone body metabolic process (GO:0046950)2.75100593
59protein localization to cilium (GO:0061512)2.74495574
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.74428696
61piRNA metabolic process (GO:0034587)2.74246111
62regulation of nuclear cell cycle DNA replication (GO:0033262)2.71507272
63S-adenosylmethionine metabolic process (GO:0046500)2.69196445
64sulfation (GO:0051923)2.68291319
65somite development (GO:0061053)2.64854805
66negative regulation of telomere maintenance (GO:0032205)2.63187091
67regulation of meiosis I (GO:0060631)2.62693515
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62367224
69platelet dense granule organization (GO:0060155)2.62198583
70axoneme assembly (GO:0035082)2.62119180
71tRNA processing (GO:0008033)2.61830494
72ketone body metabolic process (GO:1902224)2.60615454
73retinal cone cell development (GO:0046549)2.59425868
74cilium organization (GO:0044782)2.57813262
75mannosylation (GO:0097502)2.57536895
76signal peptide processing (GO:0006465)2.57053555
77proteasome assembly (GO:0043248)2.57031609
78response to pheromone (GO:0019236)2.56929966
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53243539
80somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.53163651
81isotype switching (GO:0045190)2.53163651
82somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.53163651
83cilium assembly (GO:0042384)2.48923393
84nonmotile primary cilium assembly (GO:0035058)2.48605115
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48562546
86maturation of 5.8S rRNA (GO:0000460)2.47819532
87dopamine transport (GO:0015872)2.46542687
88protein polyglutamylation (GO:0018095)2.46181693
89DNA catabolic process, exonucleolytic (GO:0000738)2.45163102
90cilium movement (GO:0003341)2.44287921
91rRNA catabolic process (GO:0016075)2.43813596
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.42680906
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.42680906
94sequestering of actin monomers (GO:0042989)2.41005130
95male meiosis (GO:0007140)2.40786500
96regulation of telomere maintenance (GO:0032204)2.39631290
97tRNA modification (GO:0006400)2.39194462
98meiotic chromosome segregation (GO:0045132)2.38573511
99DNA replication checkpoint (GO:0000076)2.37338056
100negative regulation of transcription regulatory region DNA binding (GO:2000678)2.36138009

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.54534986
2VDR_22108803_ChIP-Seq_LS180_Human3.49423191
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06255381
4GBX2_23144817_ChIP-Seq_PC3_Human2.64170408
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63981277
6IGF1R_20145208_ChIP-Seq_DFB_Human2.60477424
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55093810
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54443489
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.52179571
10EWS_26573619_Chip-Seq_HEK293_Human2.51880861
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.49880427
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49404904
13FUS_26573619_Chip-Seq_HEK293_Human2.46435733
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.46419206
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43198577
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.38104573
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27102413
18TAF15_26573619_Chip-Seq_HEK293_Human2.23767509
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23543758
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06397231
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05299727
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03756820
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99604244
24P300_19829295_ChIP-Seq_ESCs_Human1.98811369
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.98664843
26ELK1_19687146_ChIP-ChIP_HELA_Human1.92262068
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87787388
28ER_23166858_ChIP-Seq_MCF-7_Human1.87290366
29VDR_23849224_ChIP-Seq_CD4+_Human1.81858615
30MYC_18940864_ChIP-ChIP_HL60_Human1.68348777
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65786027
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62727849
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61650295
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56914230
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51536958
36CBP_20019798_ChIP-Seq_JUKART_Human1.50611317
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50611317
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49601819
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47936112
40BCAT_22108803_ChIP-Seq_LS180_Human1.46896972
41IRF1_19129219_ChIP-ChIP_H3396_Human1.46390820
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46250675
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43162491
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.41170480
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.39864970
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39582389
47TP53_22573176_ChIP-Seq_HFKS_Human1.39369358
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37848180
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36542040
50STAT3_23295773_ChIP-Seq_U87_Human1.35735932
51SMAD4_21799915_ChIP-Seq_A2780_Human1.34139098
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.32548362
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31582734
54FOXP3_21729870_ChIP-Seq_TREG_Human1.30368562
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30054106
56SOX2_19829295_ChIP-Seq_ESCs_Human1.25743717
57NANOG_19829295_ChIP-Seq_ESCs_Human1.25743717
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25645232
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25247332
60TCF4_23295773_ChIP-Seq_U87_Human1.24092716
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23944998
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23834346
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22942897
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22762593
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21763834
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18697349
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18697349
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.18104509
69TCF4_22108803_ChIP-Seq_LS180_Human1.17978757
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16778407
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.16686811
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.16094885
73AR_25329375_ChIP-Seq_VCAP_Human1.15855581
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.15781273
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15650759
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14943672
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.14943672
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11674742
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.10883578
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10647263
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10589551
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09905552
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.05541072
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05194014
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.05139245
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04483402
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.04298267
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03963656
89HOXB7_26014856_ChIP-Seq_BT474_Human1.03790656
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03649154
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02375799
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02344929
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01240600
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00687632
95RUNX2_22187159_ChIP-Seq_PCA_Human1.00478309
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98843460
97RNF2_27304074_Chip-Seq_NSC_Mouse0.98653068
98P53_22387025_ChIP-Seq_ESCs_Mouse0.97967591
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97575883
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.97384697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.24592436
2MP0002837_dystrophic_cardiac_calcinosis3.11293319
3MP0008877_abnormal_DNA_methylation3.09878381
4MP0008058_abnormal_DNA_repair2.88430716
5MP0002102_abnormal_ear_morphology2.78621992
6MP0006072_abnormal_retinal_apoptosis2.47204109
7MP0000372_irregular_coat_pigmentation2.35007883
8MP0005551_abnormal_eye_electrophysiolog2.22039966
9MP0000569_abnormal_digit_pigmentation2.19450767
10MP0003195_calcinosis2.16526377
11MP0002638_abnormal_pupillary_reflex2.10925925
12MP0008057_abnormal_DNA_replication2.06492854
13MP0002938_white_spotting2.02025648
14MP0008995_early_reproductive_senescence1.99423480
15MP0004145_abnormal_muscle_electrophysio1.99072119
16MP0001529_abnormal_vocalization1.97868104
17MP0005253_abnormal_eye_physiology1.93125702
18MP0003136_yellow_coat_color1.89811056
19MP0004142_abnormal_muscle_tone1.83864938
20MP0004147_increased_porphyrin_level1.79152046
21MP0009697_abnormal_copulation1.74468823
22MP0006292_abnormal_olfactory_placode1.68900648
23MP0010094_abnormal_chromosome_stability1.64495878
24MP0005084_abnormal_gallbladder_morpholo1.60133921
25MP0003786_premature_aging1.59486503
26MP0004133_heterotaxia1.56992027
27MP0002160_abnormal_reproductive_system1.47957600
28MP0002928_abnormal_bile_duct1.44931312
29MP0001968_abnormal_touch/_nociception1.44071185
30MP0005645_abnormal_hypothalamus_physiol1.40870689
31MP0000631_abnormal_neuroendocrine_gland1.39866281
32MP0001485_abnormal_pinna_reflex1.35193699
33MP0005646_abnormal_pituitary_gland1.35170982
34MP0001984_abnormal_olfaction1.34534703
35MP0006276_abnormal_autonomic_nervous1.34253204
36MP0004043_abnormal_pH_regulation1.33197020
37MP0008872_abnormal_physiological_respon1.31720901
38MP0002736_abnormal_nociception_after1.28791735
39MP0005389_reproductive_system_phenotype1.27317333
40MP0004742_abnormal_vestibular_system1.23902467
41MP0001501_abnormal_sleep_pattern1.23153106
42MP0003937_abnormal_limbs/digits/tail_de1.21161052
43MP0003718_maternal_effect1.19881162
44MP0004215_abnormal_myocardial_fiber1.19678545
45MP0009046_muscle_twitch1.19189237
46MP0000427_abnormal_hair_cycle1.18207192
47MP0003890_abnormal_embryonic-extraembry1.17376349
48MP0006036_abnormal_mitochondrial_physio1.16215315
49MP0010386_abnormal_urinary_bladder1.14749535
50MP0000383_abnormal_hair_follicle1.14682079
51MP0008875_abnormal_xenobiotic_pharmacok1.13368987
52MP0003252_abnormal_bile_duct1.11525984
53MP0001919_abnormal_reproductive_system1.11070586
54MP0001929_abnormal_gametogenesis1.10624735
55MP0006035_abnormal_mitochondrial_morpho1.09524326
56MP0005367_renal/urinary_system_phenotyp1.07925003
57MP0000516_abnormal_urinary_system1.07925003
58MP0005410_abnormal_fertilization1.07206201
59MP0002234_abnormal_pharynx_morphology1.04417152
60MP0003698_abnormal_male_reproductive1.03802250
61MP0008775_abnormal_heart_ventricle1.03383288
62MP0004885_abnormal_endolymph1.01978125
63MP0003950_abnormal_plasma_membrane0.98354180
64MP0001486_abnormal_startle_reflex0.96106019
65MP0002210_abnormal_sex_determination0.95849484
66MP0005075_abnormal_melanosome_morpholog0.92964595
67MP0009745_abnormal_behavioral_response0.91840919
68MP0000653_abnormal_sex_gland0.91480823
69MP0000749_muscle_degeneration0.90987929
70MP0008789_abnormal_olfactory_epithelium0.90285430
71MP0003787_abnormal_imprinting0.90035676
72MP0005195_abnormal_posterior_eye0.88975590
73MP0005171_absent_coat_pigmentation0.88867613
74MP0002751_abnormal_autonomic_nervous0.88606728
75MP0008961_abnormal_basal_metabolism0.87840162
76MP0002653_abnormal_ependyma_morphology0.85801907
77MP0005386_behavior/neurological_phenoty0.85586776
78MP0004924_abnormal_behavior0.85586776
79MP0000538_abnormal_urinary_bladder0.85127405
80MP0003693_abnormal_embryo_hatching0.84997701
81MP0002876_abnormal_thyroid_physiology0.84884518
82MP0001145_abnormal_male_reproductive0.84838066
83MP0003567_abnormal_fetal_cardiomyocyte0.84812357
84MP0005174_abnormal_tail_pigmentation0.84728319
85MP0002272_abnormal_nervous_system0.84416818
86MP0002282_abnormal_trachea_morphology0.83245572
87MP0001764_abnormal_homeostasis0.82868786
88MP0005391_vision/eye_phenotype0.80398994
89MP0005266_abnormal_metabolism0.79691010
90MP0005083_abnormal_biliary_tract0.78217192
91MP0001986_abnormal_taste_sensitivity0.77828735
92MP0003137_abnormal_impulse_conducting0.77159413
93MP0005187_abnormal_penis_morphology0.76156363
94MP0002752_abnormal_somatic_nervous0.74016602
95MP0003880_abnormal_central_pattern0.73824846
96MP0002693_abnormal_pancreas_physiology0.72634845
97MP0000647_abnormal_sebaceous_gland0.71817811
98MP0001324_abnormal_eye_pigmentation0.71478005
99MP0003119_abnormal_digestive_system0.71365645
100MP0002095_abnormal_skin_pigmentation0.71097475

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.09883599
2Pancreatic fibrosis (HP:0100732)3.80863871
3Molar tooth sign on MRI (HP:0002419)3.67361793
4Abnormality of midbrain morphology (HP:0002418)3.67361793
5True hermaphroditism (HP:0010459)3.51210758
6Nephronophthisis (HP:0000090)3.34831010
7Congenital stationary night blindness (HP:0007642)3.15552903
8Abnormality of the renal cortex (HP:0011035)3.14675791
9Medial flaring of the eyebrow (HP:0010747)3.03162034
10Abnormality of the renal medulla (HP:0100957)2.97333101
11Acute necrotizing encephalopathy (HP:0006965)2.92058128
12Lipid accumulation in hepatocytes (HP:0006561)2.79749729
13Increased hepatocellular lipid droplets (HP:0006565)2.78742276
14Mitochondrial inheritance (HP:0001427)2.77454417
15Progressive macrocephaly (HP:0004481)2.72539981
16Increased CSF lactate (HP:0002490)2.71781806
17Renal cortical cysts (HP:0000803)2.71375219
18Type II lissencephaly (HP:0007260)2.71328367
19Abnormality of the pons (HP:0007361)2.69277634
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.64322721
21Duplicated collecting system (HP:0000081)2.59851708
22Attenuation of retinal blood vessels (HP:0007843)2.56098257
23Large for gestational age (HP:0001520)2.55811227
24Chronic hepatic failure (HP:0100626)2.52513937
25Abnormal biliary tract physiology (HP:0012439)2.52427847
26Bile duct proliferation (HP:0001408)2.52427847
27Abnormality of the ileum (HP:0001549)2.52029052
28Acute encephalopathy (HP:0006846)2.51204980
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46390410
30Abnormality of the renal collecting system (HP:0004742)2.46068040
31Hypoplasia of the pons (HP:0012110)2.44517516
32Hepatocellular necrosis (HP:0001404)2.43988017
33Meckel diverticulum (HP:0002245)2.43481876
34Abnormal mitochondria in muscle tissue (HP:0008316)2.40871163
35Methylmalonic acidemia (HP:0002912)2.37228732
36Chromsome breakage (HP:0040012)2.35272381
37Congenital primary aphakia (HP:0007707)2.30861969
38Congenital, generalized hypertrichosis (HP:0004540)2.30103560
39Abnormality of the labia minora (HP:0012880)2.30041757
40Abnormality of alanine metabolism (HP:0010916)2.29774461
41Hyperalaninemia (HP:0003348)2.29774461
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29774461
43Cystic liver disease (HP:0006706)2.28818537
44Tubular atrophy (HP:0000092)2.26264864
45Gait imbalance (HP:0002141)2.24877052
46Hepatic necrosis (HP:0002605)2.24830914
47Cerebellar dysplasia (HP:0007033)2.19967647
48Hypothermia (HP:0002045)2.14251429
49Sclerocornea (HP:0000647)2.13455587
503-Methylglutaconic aciduria (HP:0003535)2.13330305
51Abnormality of chromosome stability (HP:0003220)2.11820444
52Nephrogenic diabetes insipidus (HP:0009806)2.09927143
53Colon cancer (HP:0003003)2.09354441
54Clubbing of toes (HP:0100760)2.08607540
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.07278703
56Hyperventilation (HP:0002883)2.05699097
57Optic disc pallor (HP:0000543)2.04527084
58Anencephaly (HP:0002323)2.03908751
59Genital tract atresia (HP:0001827)2.03586455
60Intestinal atresia (HP:0011100)2.03475169
61Absent thumb (HP:0009777)2.01325011
62Lissencephaly (HP:0001339)2.01090237
63Exertional dyspnea (HP:0002875)2.00909643
64Volvulus (HP:0002580)1.99219441
65Ectopic kidney (HP:0000086)1.96158269
66Sloping forehead (HP:0000340)1.95338417
67Abnormality of DNA repair (HP:0003254)1.93938292
68Renal Fanconi syndrome (HP:0001994)1.93653748
69Vaginal atresia (HP:0000148)1.93219467
70Optic nerve hypoplasia (HP:0000609)1.92106578
71Increased serum lactate (HP:0002151)1.89596837
72Postaxial foot polydactyly (HP:0001830)1.88703663
73Poor coordination (HP:0002370)1.88123398
74Furrowed tongue (HP:0000221)1.88049461
75Congenital hepatic fibrosis (HP:0002612)1.87409064
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86137770
77Methylmalonic aciduria (HP:0012120)1.85886038
78Aplasia/Hypoplasia of the tibia (HP:0005772)1.85523056
79Male pseudohermaphroditism (HP:0000037)1.84693295
80Abnormal rod and cone electroretinograms (HP:0008323)1.84333362
81Stomach cancer (HP:0012126)1.84074539
82Abnormal drinking behavior (HP:0030082)1.82877995
83Polydipsia (HP:0001959)1.82877995
84Inability to walk (HP:0002540)1.82746081
85Abnormality of the preputium (HP:0100587)1.82037793
86Abolished electroretinogram (ERG) (HP:0000550)1.79226311
87Pendular nystagmus (HP:0012043)1.78799781
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77885253
89Cerebral edema (HP:0002181)1.75962159
90Abnormal number of erythroid precursors (HP:0012131)1.75359314
91Astigmatism (HP:0000483)1.74898903
92Progressive inability to walk (HP:0002505)1.73567481
93Gastrointestinal atresia (HP:0002589)1.72838217
94Abnormality of vitamin B metabolism (HP:0004340)1.67664354
95Lactic acidosis (HP:0003128)1.67489438
96Calf muscle hypertrophy (HP:0008981)1.67411965
97Dandy-Walker malformation (HP:0001305)1.67400735
98Muscle hypertrophy of the lower extremities (HP:0008968)1.65834743
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.64683260
100Type 2 muscle fiber atrophy (HP:0003554)1.64348863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.15216959
2NUAK12.74655263
3MAP4K22.73629592
4WNK32.69903019
5ZAK2.56329148
6GRK12.44135708
7PINK12.40598892
8BMPR1B2.22917863
9ADRBK22.17294883
10TNIK2.11794357
11PNCK1.93829782
12INSRR1.86397126
13OBSCN1.85138572
14MKNK21.80733974
15EIF2AK31.79764566
16VRK11.76605384
17VRK21.75873876
18ACVR1B1.72927259
19TLK11.70209075
20TAOK31.56197423
21AKT31.51206275
22CCNB11.47103198
23TIE11.42245879
24WEE11.42033778
25OXSR11.39735464
26BUB11.38826170
27BRSK21.38218263
28TXK1.37440899
29TAF11.35947154
30MAP3K41.33720842
31WNK41.31619799
32NLK1.31205846
33FGFR21.27957414
34TRIM281.24468849
35MST41.24071414
36MKNK11.21278603
37NME11.18059011
38TSSK61.16591814
39CASK1.15894328
40PLK31.15450710
41MAPK151.10008004
42PLK41.07973590
43STK391.07831033
44MAPK131.05436160
45TGFBR11.04478715
46SRPK11.00242569
47NEK20.92929757
48TEC0.92847933
49PIK3CG0.91895853
50PAK30.87878065
51DYRK20.87253504
52MUSK0.84720210
53CSNK1G10.83986277
54PHKG10.80523415
55PHKG20.80523415
56ERBB30.78160533
57CDC70.72788014
58MAPKAPK30.69530890
59NEK10.69049670
60STK38L0.67043579
61PLK20.65262145
62CSNK1A1L0.65214288
63CSNK1G20.65155175
64PLK10.63475952
65ATR0.63090178
66CSNK1G30.62921178
67PASK0.62610205
68PRKCE0.61460300
69EIF2AK20.60684404
70ADRBK10.59247879
71CDK30.55108027
72CAMKK20.54955816
73IKBKB0.54892148
74CAMK1G0.54205826
75STK30.53087410
76PDK20.51370371
77MAP2K70.50562731
78ATM0.50429606
79CHUK0.50156589
80PRKCG0.50102365
81MARK30.49285424
82STK160.48810858
83MELK0.48651207
84MAPKAPK50.47182851
85EIF2AK10.46339350
86CHEK20.46323187
87RPS6KA50.43453640
88PIK3CA0.42854576
89MARK10.40853340
90SGK20.38853969
91MAP2K60.36817735
92PRKCQ0.35805362
93CSNK1A10.34556939
94PTK2B0.34155065
95MAP4K10.32374420
96EPHA30.31887892
97TRPM70.30775986
98BCR0.30625059
99LATS10.30482039
100PRKG10.29792464

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.09940760
2Oxidative phosphorylation_Homo sapiens_hsa001902.81682479
3Fanconi anemia pathway_Homo sapiens_hsa034602.80101071
4RNA polymerase_Homo sapiens_hsa030202.64493001
5Basal transcription factors_Homo sapiens_hsa030222.50826421
6Protein export_Homo sapiens_hsa030602.48186927
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46630618
8Phototransduction_Homo sapiens_hsa047442.39316339
9Parkinsons disease_Homo sapiens_hsa050122.33365499
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20654843
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19804897
12Proteasome_Homo sapiens_hsa030502.12266819
13Nitrogen metabolism_Homo sapiens_hsa009102.02758223
14RNA degradation_Homo sapiens_hsa030182.02733364
15Selenocompound metabolism_Homo sapiens_hsa004501.98887901
16Butanoate metabolism_Homo sapiens_hsa006501.94499434
17One carbon pool by folate_Homo sapiens_hsa006701.86903175
18Non-homologous end-joining_Homo sapiens_hsa034501.79365574
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.74563584
20Propanoate metabolism_Homo sapiens_hsa006401.70587178
21Linoleic acid metabolism_Homo sapiens_hsa005911.69751642
22Mismatch repair_Homo sapiens_hsa034301.62401408
23Huntingtons disease_Homo sapiens_hsa050161.60451204
24Nucleotide excision repair_Homo sapiens_hsa034201.54677167
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53588565
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52873929
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48797697
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45576181
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45211825
30Alzheimers disease_Homo sapiens_hsa050101.41437775
31Ribosome_Homo sapiens_hsa030101.40495486
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40425707
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35291448
34Tryptophan metabolism_Homo sapiens_hsa003801.31345488
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28957189
36Cardiac muscle contraction_Homo sapiens_hsa042601.28553602
37RNA transport_Homo sapiens_hsa030131.23079092
38Purine metabolism_Homo sapiens_hsa002301.19660511
39Taste transduction_Homo sapiens_hsa047421.14130735
40Regulation of autophagy_Homo sapiens_hsa041401.12335882
41Pyrimidine metabolism_Homo sapiens_hsa002401.11359141
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09854641
43Olfactory transduction_Homo sapiens_hsa047401.06083963
44DNA replication_Homo sapiens_hsa030301.03531856
45Caffeine metabolism_Homo sapiens_hsa002320.98447987
46Ether lipid metabolism_Homo sapiens_hsa005650.97675785
47Circadian rhythm_Homo sapiens_hsa047100.96998138
48Spliceosome_Homo sapiens_hsa030400.95939464
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.94990426
50Nicotine addiction_Homo sapiens_hsa050330.92508601
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92357656
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88851736
53Peroxisome_Homo sapiens_hsa041460.88191296
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88136914
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.86809899
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.84949103
57Asthma_Homo sapiens_hsa053100.80601268
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.76570321
59Base excision repair_Homo sapiens_hsa034100.76195317
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74247106
61Chemical carcinogenesis_Homo sapiens_hsa052040.73694401
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72499492
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71427385
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67505812
65Hedgehog signaling pathway_Homo sapiens_hsa043400.65725910
66Metabolic pathways_Homo sapiens_hsa011000.63072337
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62565150
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62545365
69ABC transporters_Homo sapiens_hsa020100.61255556
70Basal cell carcinoma_Homo sapiens_hsa052170.59197970
71Primary immunodeficiency_Homo sapiens_hsa053400.59011893
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58851654
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56494774
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56403915
75Lysine degradation_Homo sapiens_hsa003100.54610618
76Type I diabetes mellitus_Homo sapiens_hsa049400.53304798
77TGF-beta signaling pathway_Homo sapiens_hsa043500.51258157
78p53 signaling pathway_Homo sapiens_hsa041150.49091966
79beta-Alanine metabolism_Homo sapiens_hsa004100.46500568
80Retinol metabolism_Homo sapiens_hsa008300.45875312
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45757842
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43284241
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42840321
84Glycerolipid metabolism_Homo sapiens_hsa005610.41362834
85Calcium signaling pathway_Homo sapiens_hsa040200.40465918
86Arachidonic acid metabolism_Homo sapiens_hsa005900.39591007
87Serotonergic synapse_Homo sapiens_hsa047260.38714342
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37612278
89Autoimmune thyroid disease_Homo sapiens_hsa053200.36694254
90Vitamin digestion and absorption_Homo sapiens_hsa049770.35565519
91Ovarian steroidogenesis_Homo sapiens_hsa049130.35428324
92Cell cycle_Homo sapiens_hsa041100.35162620
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34775566
94Allograft rejection_Homo sapiens_hsa053300.34663344
95Pyruvate metabolism_Homo sapiens_hsa006200.33639840
96Graft-versus-host disease_Homo sapiens_hsa053320.30333542
97Systemic lupus erythematosus_Homo sapiens_hsa053220.29266806
98Morphine addiction_Homo sapiens_hsa050320.29168601
99Insulin secretion_Homo sapiens_hsa049110.28045887
100Mineral absorption_Homo sapiens_hsa049780.27859366

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