TIMM10B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.57714834
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.75404995
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.64144923
4ATP synthesis coupled proton transport (GO:0015986)5.64144923
5protein complex biogenesis (GO:0070271)5.59993943
6respiratory electron transport chain (GO:0022904)5.44961625
7ribosomal small subunit biogenesis (GO:0042274)5.43558296
8mitochondrial respiratory chain complex I assembly (GO:0032981)5.41650922
9NADH dehydrogenase complex assembly (GO:0010257)5.41650922
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.41650922
11electron transport chain (GO:0022900)5.31613107
12viral transcription (GO:0019083)5.16527438
13ribosomal small subunit assembly (GO:0000028)5.10581624
14cotranslational protein targeting to membrane (GO:0006613)4.99894821
15mitochondrial respiratory chain complex assembly (GO:0033108)4.96912373
16chaperone-mediated protein transport (GO:0072321)4.95603017
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.93882972
18protein targeting to ER (GO:0045047)4.91106119
19translational termination (GO:0006415)4.89005985
20protein neddylation (GO:0045116)4.87656158
21DNA deamination (GO:0045006)4.84505272
22protein localization to endoplasmic reticulum (GO:0070972)4.71162885
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.69644803
24proteasome assembly (GO:0043248)4.65598714
25respiratory chain complex IV assembly (GO:0008535)4.02470686
26translational elongation (GO:0006414)4.00602057
27axon ensheathment in central nervous system (GO:0032291)4.00075298
28central nervous system myelination (GO:0022010)4.00075298
29viral life cycle (GO:0019058)3.98403736
30signal peptide processing (GO:0006465)3.95164800
31GTP biosynthetic process (GO:0006183)3.94390940
32cellular protein complex disassembly (GO:0043624)3.91236692
33ribosome assembly (GO:0042255)3.87669647
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.82533420
35termination of RNA polymerase III transcription (GO:0006386)3.82533420
36cytochrome complex assembly (GO:0017004)3.82075306
37mannosylation (GO:0097502)3.81861130
38somatic hypermutation of immunoglobulin genes (GO:0016446)3.80624931
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80624931
40ribosomal large subunit biogenesis (GO:0042273)3.78245940
41GPI anchor biosynthetic process (GO:0006506)3.77032411
42translation (GO:0006412)3.67848674
43ubiquinone metabolic process (GO:0006743)3.66950078
44maturation of 5.8S rRNA (GO:0000460)3.65340710
45L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.44251640
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42164809
47regulation of mitotic spindle checkpoint (GO:1903504)3.42164809
48regulation of mitochondrial translation (GO:0070129)3.40977141
49maturation of SSU-rRNA (GO:0030490)3.36771122
50preassembly of GPI anchor in ER membrane (GO:0016254)3.34428261
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.34270378
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33040872
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.31609882
54* protein targeting to mitochondrion (GO:0006626)3.30932726
55establishment of viral latency (GO:0019043)3.30464569
56translational initiation (GO:0006413)3.29206337
57GPI anchor metabolic process (GO:0006505)3.27778013
58isoprenoid biosynthetic process (GO:0008299)3.26723808
59fatty acid elongation (GO:0030497)3.25649069
60cullin deneddylation (GO:0010388)3.25638495
61rRNA modification (GO:0000154)3.24578210
62mitochondrial RNA metabolic process (GO:0000959)3.24372961
63iron-sulfur cluster assembly (GO:0016226)3.22812482
64metallo-sulfur cluster assembly (GO:0031163)3.22812482
65protein-cofactor linkage (GO:0018065)3.22576246
66hydrogen ion transmembrane transport (GO:1902600)3.22330952
67C-terminal protein lipidation (GO:0006501)3.22139304
68CENP-A containing nucleosome assembly (GO:0034080)3.19874534
69inner mitochondrial membrane organization (GO:0007007)3.18863123
70UTP biosynthetic process (GO:0006228)3.18356173
71peptidyl-histidine modification (GO:0018202)3.18155170
72platelet dense granule organization (GO:0060155)3.18079333
73branched-chain amino acid catabolic process (GO:0009083)3.17424798
74protein targeting to membrane (GO:0006612)3.17262581
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15732651
76chromatin remodeling at centromere (GO:0031055)3.15341199
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15229505
78cholesterol biosynthetic process (GO:0006695)3.14235608
79purine nucleobase biosynthetic process (GO:0009113)3.13288250
80CTP metabolic process (GO:0046036)3.12950232
81CTP biosynthetic process (GO:0006241)3.12950232
82protein complex disassembly (GO:0043241)3.12279810
83guanosine-containing compound biosynthetic process (GO:1901070)3.11415811
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10629791
85pseudouridine synthesis (GO:0001522)3.10432352
86* establishment of protein localization to mitochondrion (GO:0072655)3.07643150
87histone mRNA metabolic process (GO:0008334)3.07134715
88cellular component biogenesis (GO:0044085)3.07132381
89somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.04397874
90isotype switching (GO:0045190)3.04397874
91somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.04397874
92protein deneddylation (GO:0000338)3.03758592
93sterol biosynthetic process (GO:0016126)3.00761157
94macromolecular complex disassembly (GO:0032984)3.00593356
95purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99822891
96DNA replication checkpoint (GO:0000076)2.99746713
97nucleotide transmembrane transport (GO:1901679)2.99410019
98presynaptic membrane assembly (GO:0097105)2.99114866
99proton transport (GO:0015992)2.98702670
100establishment of integrated proviral latency (GO:0075713)2.97609419
101rRNA catabolic process (GO:0016075)2.97483092
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95646654
103L-methionine biosynthetic process (GO:0071265)2.95245838
104amino acid salvage (GO:0043102)2.95245838
105L-methionine salvage (GO:0071267)2.95245838
106purine nucleoside triphosphate biosynthetic process (GO:0009145)2.94456973
107DNA double-strand break processing (GO:0000729)2.94450324
108nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93017699
109ubiquinone biosynthetic process (GO:0006744)2.92787066
110organelle disassembly (GO:1903008)2.92454843
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90969951
112hydrogen transport (GO:0006818)2.88992379
1137-methylguanosine mRNA capping (GO:0006370)2.88102034
114mitotic metaphase plate congression (GO:0007080)2.88079146
115DNA catabolic process, exonucleolytic (GO:0000738)2.87953297
116mismatch repair (GO:0006298)2.87898774
117RNA capping (GO:0036260)2.87135987
1187-methylguanosine RNA capping (GO:0009452)2.87135987
119pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85686293
120regulation of cellular amino acid metabolic process (GO:0006521)2.84572644
121negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81226160
122nucleobase biosynthetic process (GO:0046112)2.79238115
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78986682
124antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.77958883
125dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.77602342
126C-terminal protein amino acid modification (GO:0018410)2.76997216
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76423328
128protein localization to kinetochore (GO:0034501)2.75984124
129tRNA processing (GO:0008033)2.75234059
130GDP-mannose metabolic process (GO:0019673)2.75150787
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74368191
132histone exchange (GO:0043486)2.74338667
133positive regulation of protein homodimerization activity (GO:0090073)2.74303635
134negative regulation of DNA recombination (GO:0045910)2.73883113
135* protein localization to mitochondrion (GO:0070585)2.73309645
136water-soluble vitamin biosynthetic process (GO:0042364)2.73290419
137ATP biosynthetic process (GO:0006754)2.72803448
138rRNA methylation (GO:0031167)2.72576278
139ribonucleoprotein complex disassembly (GO:0032988)2.71169393
140positive regulation of ligase activity (GO:0051351)2.69878861
141ribonucleoside triphosphate biosynthetic process (GO:0009201)2.69748648
142tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69707840
143RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69707840
144tRNA metabolic process (GO:0006399)2.69007709
145intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68494116
146signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68494116
147methionine biosynthetic process (GO:0009086)2.67934696
148replication fork processing (GO:0031297)2.67425141
149viral protein processing (GO:0019082)2.66842234
150somatic diversification of immunoglobulins (GO:0016445)2.66415108
151negative regulation of ligase activity (GO:0051352)2.66269228
152negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.66269228
153signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66261054
154S-adenosylmethionine metabolic process (GO:0046500)2.61327729
155signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58943301
156signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58943301
157amino acid activation (GO:0043038)2.56707815
158tRNA aminoacylation (GO:0043039)2.56707815
159pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.56228544
160DNA replication-dependent nucleosome assembly (GO:0006335)2.53687385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.52402043
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.33904579
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.16150165
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.15930829
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.09147304
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.64896562
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.63421207
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.32211375
9E2F7_22180533_ChIP-Seq_HELA_Human3.14855043
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.98442843
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93414801
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79303551
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69987485
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.60684331
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59134067
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55072739
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.51962526
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50019893
19ZNF274_21170338_ChIP-Seq_K562_Hela2.48101856
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45607670
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34830370
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19592798
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.15861368
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.12003186
25VDR_23849224_ChIP-Seq_CD4+_Human2.09931927
26PADI4_21655091_ChIP-ChIP_MCF-7_Human2.05941959
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95945861
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94465930
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.94287850
30DCP1A_22483619_ChIP-Seq_HELA_Human1.87688178
31ELK1_19687146_ChIP-ChIP_HELA_Human1.86047142
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.80685918
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77993607
34GBX2_23144817_ChIP-Seq_PC3_Human1.69337097
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68060243
36FOXP3_21729870_ChIP-Seq_TREG_Human1.67982272
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66647168
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65413781
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63647836
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60127954
41IRF1_19129219_ChIP-ChIP_H3396_Human1.57859287
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57825575
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56276900
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55758423
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48713887
46TAF15_26573619_Chip-Seq_HEK293_Human1.48211517
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45674663
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45586444
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44261445
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44202558
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44067696
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.41101720
53TTF2_22483619_ChIP-Seq_HELA_Human1.40339226
54VDR_22108803_ChIP-Seq_LS180_Human1.40035353
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.39069546
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38898899
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34435364
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.34255220
59XRN2_22483619_ChIP-Seq_HELA_Human1.32738554
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32481397
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32029848
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31083074
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30656087
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29935073
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29319151
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26979629
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.24258677
68GABP_19822575_ChIP-Seq_HepG2_Human1.22985041
69CIITA_25753668_ChIP-Seq_RAJI_Human1.18515169
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18315496
71MYC_18940864_ChIP-ChIP_HL60_Human1.17241712
72IGF1R_20145208_ChIP-Seq_DFB_Human1.14435806
73KDM5A_27292631_Chip-Seq_BREAST_Human1.12973614
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09060665
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08939786
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07820720
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04982994
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.04729125
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04320166
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04210123
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04195482
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04001876
83ER_23166858_ChIP-Seq_MCF-7_Human1.02794558
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.02354825
85TP53_22573176_ChIP-Seq_HFKS_Human1.01950206
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01463638
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01208685
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99837196
89FUS_26573619_Chip-Seq_HEK293_Human0.99356892
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95998468
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.95836602
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95801529
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95341702
94STAT1_20625510_ChIP-Seq_HELA_Human0.93899219
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92537706
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91397005
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90018862
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.90018862
99EWS_26573619_Chip-Seq_HEK293_Human0.88573888
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.88026406
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87831634
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87791702
103FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86167237
104TFEB_21752829_ChIP-Seq_HELA_Human0.85722128
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83831398
106AR_20517297_ChIP-Seq_VCAP_Human0.83825330
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82454226
108SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82240118
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81713954
110SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81578970
111SALL4_22934838_ChIP-ChIP_CD34+_Human0.81325818
112PHF8_20622853_ChIP-Seq_HELA_Human0.81185915
113TAL1_26923725_Chip-Seq_HPCs_Mouse0.81180071
114EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80999575
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.80841276
116RNF2_27304074_Chip-Seq_NSC_Mouse0.80202015
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79644572
118RBPJ_21746931_ChIP-Seq_IB4_Human0.78856595
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78717281
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78211848
121P300_18555785_Chip-Seq_ESCs_Mouse0.77956295
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77956009
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77704104
124SPI1_23547873_ChIP-Seq_NB4_Human0.76725678
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.76169519
126NELFA_20434984_ChIP-Seq_ESCs_Mouse0.76082779
127ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75893053
128P53_22387025_ChIP-Seq_ESCs_Mouse0.74269847
129IRF8_21731497_ChIP-ChIP_J774_Mouse0.74217065
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.74160990
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.73962251
132NFE2_27457419_Chip-Seq_LIVER_Mouse0.73878787
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.73390946
134NMYC_18555785_Chip-Seq_ESCs_Mouse0.73277035
135P300_19829295_ChIP-Seq_ESCs_Human0.73245174
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72815635
137STAT4_19710469_ChIP-ChIP_TH1__Mouse0.72702243
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72244544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.36475132
2MP0008058_abnormal_DNA_repair3.88874398
3MP0003136_yellow_coat_color3.73913053
4MP0008877_abnormal_DNA_methylation3.32455754
5MP0001529_abnormal_vocalization3.08667886
6MP0001986_abnormal_taste_sensitivity3.08243228
7MP0010094_abnormal_chromosome_stability3.04824234
8MP0004957_abnormal_blastocyst_morpholog2.83311847
9MP0003880_abnormal_central_pattern2.78499526
10MP0005171_absent_coat_pigmentation2.75016470
11MP0008007_abnormal_cellular_replicative2.68757826
12MP0001905_abnormal_dopamine_level2.62839003
13MP0000372_irregular_coat_pigmentation2.53408699
14MP0001188_hyperpigmentation2.52735824
15MP0003111_abnormal_nucleus_morphology2.52148130
16MP0003693_abnormal_embryo_hatching2.47471085
17MP0004142_abnormal_muscle_tone2.37798593
18MP0005409_darkened_coat_color2.24952773
19MP0004147_increased_porphyrin_level2.24055126
20MP0002139_abnormal_hepatobiliary_system2.23978657
21MP0003195_calcinosis2.21103064
22MP0003724_increased_susceptibility_to2.18311377
23MP0004381_abnormal_hair_follicle2.13612037
24MP0003077_abnormal_cell_cycle2.04724712
25MP0002638_abnormal_pupillary_reflex2.02752045
26MP0003787_abnormal_imprinting1.92197937
27MP0006276_abnormal_autonomic_nervous1.89088569
28MP0000920_abnormal_myelination1.78633796
29MP0002148_abnormal_hypersensitivity_rea1.76868147
30MP0002736_abnormal_nociception_after1.74355996
31MP0008057_abnormal_DNA_replication1.73922545
32MP0002163_abnormal_gland_morphology1.73643834
33MP0003806_abnormal_nucleotide_metabolis1.71631821
34MP0006292_abnormal_olfactory_placode1.69928400
35MP0009697_abnormal_copulation1.65522611
36MP0008789_abnormal_olfactory_epithelium1.60616524
37MP0005645_abnormal_hypothalamus_physiol1.56617324
38MP0002132_abnormal_respiratory_system1.56240878
39MP0001968_abnormal_touch/_nociception1.50094256
40MP0005671_abnormal_response_to1.49843779
41MP0000647_abnormal_sebaceous_gland1.48689924
42MP0002272_abnormal_nervous_system1.47260192
43MP0005379_endocrine/exocrine_gland_phen1.46152650
44MP0009785_altered_susceptibility_to1.45462306
45MP0003186_abnormal_redox_activity1.39827649
46MP0000015_abnormal_ear_pigmentation1.37830478
47MP0000566_synostosis1.35978485
48MP0005075_abnormal_melanosome_morpholog1.35339294
49MP0010307_abnormal_tumor_latency1.34419268
50MP0006036_abnormal_mitochondrial_physio1.33433885
51MP0009046_muscle_twitch1.31290607
52MP0001929_abnormal_gametogenesis1.30661881
53MP0002277_abnormal_respiratory_mucosa1.30514436
54MP0004742_abnormal_vestibular_system1.29671331
55MP0002938_white_spotting1.29187909
56MP0001835_abnormal_antigen_presentation1.27606212
57MP0005332_abnormal_amino_acid1.24853666
58MP0005084_abnormal_gallbladder_morpholo1.24207674
59MP0002095_abnormal_skin_pigmentation1.23877872
60MP0005395_other_phenotype1.22753923
61MP0005636_abnormal_mineral_homeostasis1.20190370
62MP0002160_abnormal_reproductive_system1.19962033
63MP0004133_heterotaxia1.19002463
64MP0005410_abnormal_fertilization1.15617749
65MP0003122_maternal_imprinting1.15030234
66MP0010386_abnormal_urinary_bladder1.14425737
67MP0001486_abnormal_startle_reflex1.13386901
68MP0002064_seizures1.12240080
69MP0008875_abnormal_xenobiotic_pharmacok1.12134887
70MP0005174_abnormal_tail_pigmentation1.11204132
71MP0005551_abnormal_eye_electrophysiolog1.10586325
72MP0005408_hypopigmentation1.10251961
73MP0003718_maternal_effect1.10160958
74MP0003950_abnormal_plasma_membrane1.10094442
75MP0000516_abnormal_urinary_system1.09412796
76MP0005367_renal/urinary_system_phenotyp1.09412796
77MP0002876_abnormal_thyroid_physiology1.09317584
78MP0006072_abnormal_retinal_apoptosis1.08159105
79MP0005000_abnormal_immune_tolerance1.07601537
80MP0001661_extended_life_span1.05318972
81MP0006054_spinal_hemorrhage1.04242772
82MP0000358_abnormal_cell_content/1.03436180
83MP0002210_abnormal_sex_determination1.02573840
84MP0005025_abnormal_response_to1.01613316
85MP0000653_abnormal_sex_gland1.00841268
86MP0002138_abnormal_hepatobiliary_system0.99617143
87MP0003121_genomic_imprinting0.99289793
88MP0002019_abnormal_tumor_incidence0.97737445
89MP0001664_abnormal_digestion0.97098484
90MP0002735_abnormal_chemical_nociception0.96014448
91MP0002067_abnormal_sensory_capabilities0.95853425
92MP0008995_early_reproductive_senescence0.95682593
93MP0001145_abnormal_male_reproductive0.95605364
94MP0001963_abnormal_hearing_physiology0.95512706
95MP0005646_abnormal_pituitary_gland0.94966851
96MP0001970_abnormal_pain_threshold0.94090780
97MP0001790_abnormal_immune_system0.93172958
98MP0005387_immune_system_phenotype0.93172958
99MP0009333_abnormal_splenocyte_physiolog0.92594170
100MP0000689_abnormal_spleen_morphology0.92551290
101MP0002723_abnormal_immune_serum0.92293008
102MP0008873_increased_physiological_sensi0.91995230
103MP0008872_abnormal_physiological_respon0.91942265
104MP0001485_abnormal_pinna_reflex0.91939483
105MP0000026_abnormal_inner_ear0.91726624
106MP0002734_abnormal_mechanical_nocicepti0.91627300
107MP0001293_anophthalmia0.91459546
108MP0002102_abnormal_ear_morphology0.90386992
109MP0002751_abnormal_autonomic_nervous0.89941599
110MP0006035_abnormal_mitochondrial_morpho0.89474131
111MP0001542_abnormal_bone_strength0.88349167
112MP0005499_abnormal_olfactory_system0.88144414
113MP0005394_taste/olfaction_phenotype0.88144414
114MP0004043_abnormal_pH_regulation0.87457899
115MP0001984_abnormal_olfaction0.86614370
116MP0005389_reproductive_system_phenotype0.86135149
117MP0001764_abnormal_homeostasis0.85967503
118MP0002229_neurodegeneration0.85501616
119MP0009745_abnormal_behavioral_response0.84761738
120MP0002419_abnormal_innate_immunity0.84416736
121MP0003011_delayed_dark_adaptation0.84256430
122MP0006082_CNS_inflammation0.83493883
123MP0000681_abnormal_thyroid_gland0.83171254
124MP0005253_abnormal_eye_physiology0.83017413
125MP0002090_abnormal_vision0.82886687
126MP0005365_abnormal_bile_salt0.81678898
127MP0002933_joint_inflammation0.81049644
128MP0003763_abnormal_thymus_physiology0.80378825
129MP0001800_abnormal_humoral_immune0.80058977
130MP0002420_abnormal_adaptive_immunity0.79824304
131MP0000631_abnormal_neuroendocrine_gland0.79521174
132MP0001119_abnormal_female_reproductive0.79445176
133MP0001819_abnormal_immune_cell0.78409567
134MP0001730_embryonic_growth_arrest0.77998719
135MP0002752_abnormal_somatic_nervous0.76552053
136MP0001501_abnormal_sleep_pattern0.76374640
137MP0005220_abnormal_exocrine_pancreas0.76150633
138MP0000313_abnormal_cell_death0.75534908
139MP0002572_abnormal_emotion/affect_behav0.75364086
140MP0001727_abnormal_embryo_implantation0.74661202
141MP0003698_abnormal_male_reproductive0.73843015
142MP0002452_abnormal_antigen_presenting0.73782222
143MP0003567_abnormal_fetal_cardiomyocyte0.73256016
144MP0010329_abnormal_lipoprotein_level0.73233756
145MP0003646_muscle_fatigue0.73173999
146MP0005187_abnormal_penis_morphology0.72793423
147MP0003786_premature_aging0.72412105
148MP0005451_abnormal_body_composition0.71805624
149MP0000749_muscle_degeneration0.71711256
150MP0003866_abnormal_defecation0.71625511
151MP0008260_abnormal_autophagy0.71240476
152MP0003656_abnormal_erythrocyte_physiolo0.69822464
153MP0002722_abnormal_immune_system0.69787915
154MP0001440_abnormal_grooming_behavior0.69760162
155MP0001697_abnormal_embryo_size0.68962567
156MP0008932_abnormal_embryonic_tissue0.67458856
157MP0000639_abnormal_adrenal_gland0.67002475
158MP0000049_abnormal_middle_ear0.66973893
159MP0002396_abnormal_hematopoietic_system0.66683712
160MP0002733_abnormal_thermal_nociception0.66421119
161MP0001663_abnormal_digestive_system0.66058713
162MP0001853_heart_inflammation0.65672219

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.30743541
2Mitochondrial inheritance (HP:0001427)5.81441791
3Abnormal mitochondria in muscle tissue (HP:0008316)5.71410165
4Hepatocellular necrosis (HP:0001404)5.16383585
5Progressive macrocephaly (HP:0004481)5.14202113
6Acute encephalopathy (HP:0006846)4.89985121
7Increased CSF lactate (HP:0002490)4.86096066
8Increased hepatocellular lipid droplets (HP:0006565)4.66288271
93-Methylglutaconic aciduria (HP:0003535)4.62840327
10Renal Fanconi syndrome (HP:0001994)4.50409197
11Hepatic necrosis (HP:0002605)4.40027085
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.14260170
13Lipid accumulation in hepatocytes (HP:0006561)4.06465121
14Abnormality of cells of the erythroid lineage (HP:0012130)3.91699512
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.85067839
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.77916100
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.77916100
18Abnormal number of erythroid precursors (HP:0012131)3.66648229
19Exertional dyspnea (HP:0002875)3.60361515
20Optic disc pallor (HP:0000543)3.57088119
21Increased intramyocellular lipid droplets (HP:0012240)3.53698315
22Hypothermia (HP:0002045)3.51383939
23Exercise intolerance (HP:0003546)3.30894350
24Leukodystrophy (HP:0002415)3.30232270
25Respiratory failure (HP:0002878)3.25634910
26Increased serum lactate (HP:0002151)3.25438394
27Lactic acidosis (HP:0003128)3.17956509
28Increased serum pyruvate (HP:0003542)3.13434821
29Abnormality of glycolysis (HP:0004366)3.13434821
30Cerebral edema (HP:0002181)3.12322833
31Reticulocytopenia (HP:0001896)3.02915267
32Abnormality of renal resorption (HP:0011038)3.01340728
33Renal cortical cysts (HP:0000803)3.00873783
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.95846670
35Parakeratosis (HP:0001036)2.92396415
36Type I transferrin isoform profile (HP:0003642)2.90123136
37Increased muscle lipid content (HP:0009058)2.87137112
38Respiratory difficulties (HP:0002880)2.81416975
39Abnormality of midbrain morphology (HP:0002418)2.81397658
40Molar tooth sign on MRI (HP:0002419)2.81397658
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.79811474
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77410777
43Macrocytic anemia (HP:0001972)2.73804138
44Bile duct proliferation (HP:0001408)2.70139712
45Abnormal biliary tract physiology (HP:0012439)2.70139712
46Tubulointerstitial nephritis (HP:0001970)2.65630438
47Pallor (HP:0000980)2.51669793
48Microvesicular hepatic steatosis (HP:0001414)2.49860886
49Hyperglycinemia (HP:0002154)2.44367850
50Ependymoma (HP:0002888)2.40951075
51Patchy hypopigmentation of hair (HP:0011365)2.38555877
52Hypoplasia of the pons (HP:0012110)2.35422098
53Abolished electroretinogram (ERG) (HP:0000550)2.32206408
54Colon cancer (HP:0003003)2.28997541
55Glioma (HP:0009733)2.28834846
56Abnormality of the pons (HP:0007361)2.26549036
57Abnormality of methionine metabolism (HP:0010901)2.25107323
58Methylmalonic aciduria (HP:0012120)2.22831238
59Chronic bronchitis (HP:0004469)2.22206864
60Abnormality of the labia minora (HP:0012880)2.20060070
61Medial flaring of the eyebrow (HP:0010747)2.20043644
62Sensory axonal neuropathy (HP:0003390)2.18989492
63Cerebral hypomyelination (HP:0006808)2.16516603
64White forelock (HP:0002211)2.16252327
65Nephronophthisis (HP:0000090)2.15370519
66Retinal dysplasia (HP:0007973)2.13740724
67Abnormal protein glycosylation (HP:0012346)2.10249317
68Abnormal glycosylation (HP:0012345)2.10249317
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10249317
70Abnormal protein N-linked glycosylation (HP:0012347)2.10249317
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09631769
72Rhinitis (HP:0012384)2.09038815
73Hypoglycemic coma (HP:0001325)2.08129662
74Rhabdomyosarcoma (HP:0002859)2.07993484
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07949249
76Abnormal hair whorl (HP:0010721)2.05843988
77Abnormal pupillary function (HP:0007686)2.05193142
78Poor head control (HP:0002421)2.04563329
79Abnormality of serum amino acid levels (HP:0003112)2.02590487
80X-linked dominant inheritance (HP:0001423)2.01047027
81Abnormality of the renal cortex (HP:0011035)2.01008781
82True hermaphroditism (HP:0010459)2.00934714
83Abnormality of the heme biosynthetic pathway (HP:0010472)2.00665830
84Hyperphosphaturia (HP:0003109)2.00576670
85Oculomotor apraxia (HP:0000657)1.99950277
86Renal tubular dysfunction (HP:0000124)1.98746720
87Abnormality of serine family amino acid metabolism (HP:0010894)1.97493267
88Abnormality of glycine metabolism (HP:0010895)1.97493267
89Congenital ichthyosiform erythroderma (HP:0007431)1.97348628
90Abnormality of macular pigmentation (HP:0008002)1.96863862
91Medulloblastoma (HP:0002885)1.95213748
92CNS demyelination (HP:0007305)1.93183435
93Abnormality of urine glucose concentration (HP:0011016)1.93025517
94Glycosuria (HP:0003076)1.93025517
95Aplastic anemia (HP:0001915)1.90440984
96Abnormality of vitamin B metabolism (HP:0004340)1.89568718
97Progressive microcephaly (HP:0000253)1.89119985
98Abnormality of the vitamin B12 metabolism (HP:0004341)1.88722391
99Hypoproteinemia (HP:0003075)1.88361040
100Aplasia/hypoplasia of the uterus (HP:0008684)1.88313318
101Congenital sensorineural hearing impairment (HP:0008527)1.86369518
102Hyperinsulinemic hypoglycemia (HP:0000825)1.83673009
103Reduced antithrombin III activity (HP:0001976)1.82322707
104Sclerocornea (HP:0000647)1.80834780
105Abnormal respiratory motile cilium physiology (HP:0012261)1.80775044
106Emotional lability (HP:0000712)1.79919394
107Astrocytoma (HP:0009592)1.79902021
108Abnormality of the astrocytes (HP:0100707)1.79902021
109Chronic hepatic failure (HP:0100626)1.79393774
110Poor suck (HP:0002033)1.79152868
111Hyperglycinuria (HP:0003108)1.77533854
112Generalized aminoaciduria (HP:0002909)1.76486645
113Dicarboxylic aciduria (HP:0003215)1.75646353
114Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75646353
115Abnormal rod and cone electroretinograms (HP:0008323)1.73950362
116Congenital primary aphakia (HP:0007707)1.73776023
117Meckel diverticulum (HP:0002245)1.73117760
118Abnormality of the renal medulla (HP:0100957)1.71335945
119Pancreatic islet-cell hyperplasia (HP:0004510)1.71279868
120Severe visual impairment (HP:0001141)1.70808176
121Abnormality of the ileum (HP:0001549)1.70705235
122Abnormality of placental membranes (HP:0011409)1.70392577
123Amniotic constriction ring (HP:0009775)1.70392577
124Prominent metopic ridge (HP:0005487)1.69088589
125Metaphyseal dysplasia (HP:0100255)1.68613017
126Gait imbalance (HP:0002141)1.68598493
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68273673
128Abnormality of alanine metabolism (HP:0010916)1.68273673
129Hyperalaninemia (HP:0003348)1.68273673
130Abnormality of the axillary hair (HP:0100134)1.68092723
131Abnormality of secondary sexual hair (HP:0009888)1.68092723
132Nephrogenic diabetes insipidus (HP:0009806)1.67662336
133Abnormality of sulfur amino acid metabolism (HP:0004339)1.67223011
134Pancreatic fibrosis (HP:0100732)1.65096130
135Abnormal urine phosphate concentration (HP:0012599)1.64072776
136Pancreatic cysts (HP:0001737)1.63552108
137Aplasia/Hypoplasia of the fovea (HP:0008060)1.62944236
138Hypoplasia of the fovea (HP:0007750)1.62944236
139Neuroendocrine neoplasm (HP:0100634)1.61320674
140Purpura (HP:0000979)1.60180370
141Dry hair (HP:0011359)1.57583535
142Blindness (HP:0000618)1.55560459
143Hypoplasia of the uterus (HP:0000013)1.54778383
144Type 2 muscle fiber atrophy (HP:0003554)1.54385509
145Hypoplastic left heart (HP:0004383)1.52069262
146Methylmalonic acidemia (HP:0002912)1.51175350
147Lethargy (HP:0001254)1.49649865
148Pancytopenia (HP:0001876)1.44830713
149Hepatosplenomegaly (HP:0001433)1.42978805
150Abnormal hemoglobin (HP:0011902)1.42634620
151Nonprogressive disorder (HP:0003680)1.42033301
152Split foot (HP:0001839)1.40784802
153Abnormal respiratory epithelium morphology (HP:0012253)1.40662664
154Abnormal respiratory motile cilium morphology (HP:0005938)1.40662664
155Vaginal atresia (HP:0000148)1.40508829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.91963027
2CASK3.66137587
3STK163.21295189
4NME23.14247532
5TNIK2.90804620
6TLK12.82539825
7TRIM282.56403676
8CDC72.48694207
9STK392.41836923
10WNK32.37724789
11PDK22.33114257
12CDK192.09715584
13BRSK22.06009161
14TSSK62.01163760
15NME11.98451778
16VRK11.95978056
17PBK1.91993905
18MUSK1.89610365
19MST41.88508439
20GRK71.86390936
21MAP3K121.85144459
22MAP3K41.83093866
23BMPR1B1.75278817
24NEK11.71009949
25OXSR11.70842553
26MAP2K71.68718435
27BUB11.67744911
28PLK31.64780556
29PLK41.64297434
30IRAK41.63713264
31TTK1.63260608
32BLK1.57677836
33MAPKAPK51.57563198
34VRK21.55924071
35FRK1.54113331
36LIMK11.52945121
37TESK21.51497766
38PIM21.50376055
39AKT31.47813077
40ACVR1B1.45424828
41MYLK1.43147041
42SRPK11.41384996
43TXK1.38548714
44ADRBK21.35985893
45CDK81.33955720
46TEC1.31180377
47PRPF4B1.28135301
48BCR1.21115057
49EIF2AK11.19566179
50YES11.18851438
51EIF2AK31.15570073
52PLK11.13928027
53IRAK31.11066088
54CSNK1G21.10977689
55BCKDK1.04141285
56MKNK11.03737354
57EPHA31.03307062
58ARAF1.01848715
59TIE11.01300379
60PKN11.00266217
61NEK61.00180942
62KDR0.99798028
63CSNK1G30.97062068
64ZAK0.96800503
65ATR0.96736700
66IRAK10.95707795
67PINK10.91966032
68WNK40.89044647
69MKNK20.86017507
70RPS6KA50.84757909
71DYRK20.84679858
72GRK50.84098567
73BRAF0.83729229
74SIK30.83572784
75BMPR20.82871537
76ERBB30.81738969
77IRAK20.80868538
78EIF2AK20.79845856
79KIT0.79325523
80GRK10.77620224
81TAOK30.75484364
82CAMK2B0.74436254
83MAPK150.73550765
84CLK10.72047222
85INSRR0.71986232
86CAMK2D0.71478012
87BRSK10.68500474
88BTK0.67483121
89PIK3CG0.67327756
90MAPK130.66166009
91SCYL20.66036940
92LYN0.64756124
93ATM0.64021947
94CCNB10.64000953
95IKBKB0.60359026
96FLT30.60085341
97ILK0.60063700
98UHMK10.59131147
99MAP3K140.58595841
100MAP4K10.57676301
101CSNK1G10.57034374
102NLK0.55869740
103FGR0.55064677
104ITK0.54996064
105DAPK10.54756052
106AURKB0.52781173
107PIK3CA0.52578273
108CSNK1A10.52220583
109CHEK10.51667641
110SYK0.50857741
111ADRBK10.50818081
112CHEK20.50401387
113PLK20.50250853
114TNK20.50070498
115CAMK2G0.50068956
116DAPK30.49758690
117CAMK2A0.48170663
118PASK0.47882119
119ZAP700.47704032
120CSNK1A1L0.47585495
121WEE10.45816951
122CSNK2A10.45384755
123PRKCQ0.44612691
124CDK30.44568088
125OBSCN0.43858028
126NUAK10.43457909
127PRKCE0.43336219
128MAPK40.42368389
129ROCK20.42166851
130LCK0.41519298
131IGF1R0.40712260
132PAK30.39673983
133FES0.38492010
134RPS6KA40.38151023
135ALK0.38081472
136IKBKE0.37749724
137AURKA0.36921246
138CSNK2A20.35164370
139RAF10.34383904
140BRD40.32661449
141PRKACA0.32600145
142STK30.32397661
143TAF10.32238278
144MOS0.31490427
145MAP3K110.31404171
146PRKCG0.29096683
147PIM10.26077961
148CSNK1E0.25093359
149CDK10.24519735

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.22085462
2Ribosome_Homo sapiens_hsa030104.91404232
3Parkinsons disease_Homo sapiens_hsa050124.34856442
4Protein export_Homo sapiens_hsa030604.08740435
5Proteasome_Homo sapiens_hsa030503.30736256
6Alzheimers disease_Homo sapiens_hsa050103.24563144
7Huntingtons disease_Homo sapiens_hsa050163.05440943
8RNA polymerase_Homo sapiens_hsa030202.82240929
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.82091265
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35953470
11Propanoate metabolism_Homo sapiens_hsa006402.21171674
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00631127
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93277301
14Fatty acid elongation_Homo sapiens_hsa000621.91553593
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88832874
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.82610135
17One carbon pool by folate_Homo sapiens_hsa006701.69496332
18Homologous recombination_Homo sapiens_hsa034401.67683905
19Pyrimidine metabolism_Homo sapiens_hsa002401.65417368
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62959294
21Butanoate metabolism_Homo sapiens_hsa006501.59081043
22Cardiac muscle contraction_Homo sapiens_hsa042601.54671304
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.49149322
24Collecting duct acid secretion_Homo sapiens_hsa049661.44537706
25Steroid biosynthesis_Homo sapiens_hsa001001.43028823
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42501767
27Ether lipid metabolism_Homo sapiens_hsa005651.34276754
28DNA replication_Homo sapiens_hsa030301.30206450
29Selenocompound metabolism_Homo sapiens_hsa004501.29448547
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28494163
31Vibrio cholerae infection_Homo sapiens_hsa051101.21848249
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20420723
33Arachidonic acid metabolism_Homo sapiens_hsa005901.19682757
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.19149034
35Sulfur metabolism_Homo sapiens_hsa009201.18379801
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16910636
37Rheumatoid arthritis_Homo sapiens_hsa053231.16116544
38Basal transcription factors_Homo sapiens_hsa030221.15615371
39Spliceosome_Homo sapiens_hsa030401.15230051
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13721719
41Nitrogen metabolism_Homo sapiens_hsa009101.12969358
42Fatty acid metabolism_Homo sapiens_hsa012121.12636656
43Purine metabolism_Homo sapiens_hsa002301.12413950
44Mismatch repair_Homo sapiens_hsa034301.12334530
45Nucleotide excision repair_Homo sapiens_hsa034201.07743482
46Sphingolipid metabolism_Homo sapiens_hsa006001.04533342
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03405344
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97511499
49Linoleic acid metabolism_Homo sapiens_hsa005910.93530644
50Non-homologous end-joining_Homo sapiens_hsa034500.91913206
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90775482
52Base excision repair_Homo sapiens_hsa034100.89961903
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85668555
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83793363
55Metabolic pathways_Homo sapiens_hsa011000.83225812
56Fatty acid degradation_Homo sapiens_hsa000710.82638675
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79558074
58Fanconi anemia pathway_Homo sapiens_hsa034600.76811610
59beta-Alanine metabolism_Homo sapiens_hsa004100.73748552
60Carbon metabolism_Homo sapiens_hsa012000.72452844
61RNA degradation_Homo sapiens_hsa030180.72207282
62Cell cycle_Homo sapiens_hsa041100.71846337
63Other glycan degradation_Homo sapiens_hsa005110.71513888
64Glutathione metabolism_Homo sapiens_hsa004800.70930173
65Serotonergic synapse_Homo sapiens_hsa047260.68881586
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68791780
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67912928
68Primary immunodeficiency_Homo sapiens_hsa053400.67423686
69Autoimmune thyroid disease_Homo sapiens_hsa053200.67212374
70Asthma_Homo sapiens_hsa053100.65402824
71Tryptophan metabolism_Homo sapiens_hsa003800.63882431
72Systemic lupus erythematosus_Homo sapiens_hsa053220.62578289
73Folate biosynthesis_Homo sapiens_hsa007900.62127880
74Vitamin digestion and absorption_Homo sapiens_hsa049770.61165775
75Phototransduction_Homo sapiens_hsa047440.60276623
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59420142
77Phagosome_Homo sapiens_hsa041450.58610286
78Biosynthesis of amino acids_Homo sapiens_hsa012300.57377416
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.56986688
80mRNA surveillance pathway_Homo sapiens_hsa030150.56762720
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56595541
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55187190
83Allograft rejection_Homo sapiens_hsa053300.53518668
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53336440
85Graft-versus-host disease_Homo sapiens_hsa053320.52636562
86Hematopoietic cell lineage_Homo sapiens_hsa046400.51672522
87Chemical carcinogenesis_Homo sapiens_hsa052040.50876193
88Sulfur relay system_Homo sapiens_hsa041220.49641333
89p53 signaling pathway_Homo sapiens_hsa041150.49069605
90Tyrosine metabolism_Homo sapiens_hsa003500.48093648
91Alcoholism_Homo sapiens_hsa050340.48064510
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47753038
93Retinol metabolism_Homo sapiens_hsa008300.47191179
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46927413
95Malaria_Homo sapiens_hsa051440.45777541
96Vitamin B6 metabolism_Homo sapiens_hsa007500.45202779
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.42670171
98Caffeine metabolism_Homo sapiens_hsa002320.41639700
99Fat digestion and absorption_Homo sapiens_hsa049750.41495650
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40654188
101Pyruvate metabolism_Homo sapiens_hsa006200.40226444
102Nicotine addiction_Homo sapiens_hsa050330.39558152
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38906838
104Synaptic vesicle cycle_Homo sapiens_hsa047210.37402782
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36853005
106N-Glycan biosynthesis_Homo sapiens_hsa005100.36029707
107Arginine and proline metabolism_Homo sapiens_hsa003300.33782995
108Oocyte meiosis_Homo sapiens_hsa041140.32120043
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31509387
110Taste transduction_Homo sapiens_hsa047420.31322795
111Histidine metabolism_Homo sapiens_hsa003400.31086112
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31012621
113Regulation of autophagy_Homo sapiens_hsa041400.29257192
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.28133443
115Epstein-Barr virus infection_Homo sapiens_hsa051690.27876449
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27473991
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.26135499
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26031041
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23589938
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22345731
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22220232
122Morphine addiction_Homo sapiens_hsa050320.21522069
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21211582
124Peroxisome_Homo sapiens_hsa041460.18351124
125GABAergic synapse_Homo sapiens_hsa047270.13697070
126RNA transport_Homo sapiens_hsa030130.13309663
127Phenylalanine metabolism_Homo sapiens_hsa003600.12500455
128Measles_Homo sapiens_hsa051620.11446108
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.11391549
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11211700
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10265695
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.09709255
133Pertussis_Homo sapiens_hsa051330.08634123
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08260273
135Herpes simplex infection_Homo sapiens_hsa051680.07467898
136Type I diabetes mellitus_Homo sapiens_hsa049400.06793620
137African trypanosomiasis_Homo sapiens_hsa051430.06576212

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