TIMM10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.01617913
2ATP synthesis coupled proton transport (GO:0015986)7.38958946
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.38958946
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.04989574
5respiratory electron transport chain (GO:0022904)5.77171170
6electron transport chain (GO:0022900)5.62762168
7ribosomal small subunit assembly (GO:0000028)5.60956484
8proteasome assembly (GO:0043248)5.47646975
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.13527415
10mitochondrial respiratory chain complex I assembly (GO:0032981)5.13527415
11NADH dehydrogenase complex assembly (GO:0010257)5.13527415
12protein complex biogenesis (GO:0070271)5.02008705
13ribosomal small subunit biogenesis (GO:0042274)4.99383095
14viral transcription (GO:0019083)4.91122493
15maturation of SSU-rRNA (GO:0030490)4.91042920
16translational termination (GO:0006415)4.82734838
17termination of RNA polymerase III transcription (GO:0006386)4.76892747
18transcription elongation from RNA polymerase III promoter (GO:0006385)4.76892747
19DNA deamination (GO:0045006)4.74185056
20mitochondrial respiratory chain complex assembly (GO:0033108)4.73197701
21oxidative phosphorylation (GO:0006119)4.51714592
22* establishment of protein localization to mitochondrial membrane (GO:0090151)4.48517093
23regulation of mitochondrial translation (GO:0070129)4.40819653
24rRNA modification (GO:0000154)4.34743743
25* chaperone-mediated protein transport (GO:0072321)4.28873773
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.26897158
27protein neddylation (GO:0045116)4.26563925
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.26052705
29translational elongation (GO:0006414)4.25762432
30respiratory chain complex IV assembly (GO:0008535)4.25725845
31cotranslational protein targeting to membrane (GO:0006613)4.25195793
32protein targeting to ER (GO:0045047)4.18652877
337-methylguanosine mRNA capping (GO:0006370)4.16132216
34regulation of cellular amino acid metabolic process (GO:0006521)4.15724768
35RNA capping (GO:0036260)4.10796949
367-methylguanosine RNA capping (GO:0009452)4.10796949
37cullin deneddylation (GO:0010388)4.06634264
38chromatin remodeling at centromere (GO:0031055)4.06285115
39* protein targeting to mitochondrion (GO:0006626)4.04844270
40protein localization to endoplasmic reticulum (GO:0070972)4.03685123
41ribosomal large subunit biogenesis (GO:0042273)4.03597992
42CENP-A containing nucleosome assembly (GO:0034080)4.03583118
43* establishment of protein localization to mitochondrion (GO:0072655)4.01390271
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.99612223
45cellular component biogenesis (GO:0044085)3.97918456
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.97184097
47translation (GO:0006412)3.95300806
48GTP biosynthetic process (GO:0006183)3.91615163
49ribonucleoprotein complex biogenesis (GO:0022613)3.91552726
50negative regulation of ligase activity (GO:0051352)3.91138116
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.91138116
52translational initiation (GO:0006413)3.90923123
53cellular protein complex disassembly (GO:0043624)3.89474480
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.88441104
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.86230442
56protein deneddylation (GO:0000338)3.84938342
57ATP biosynthetic process (GO:0006754)3.84691950
58pseudouridine synthesis (GO:0001522)3.84552582
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.83779445
60viral life cycle (GO:0019058)3.80492508
61purine nucleoside triphosphate biosynthetic process (GO:0009145)3.80333254
62cytochrome complex assembly (GO:0017004)3.80201335
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79501126
64* protein localization to mitochondrion (GO:0070585)3.79166125
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.77267349
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.76376612
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.76035231
68guanosine-containing compound biosynthetic process (GO:1901070)3.71984873
69intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.71089414
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.71089414
71purine nucleobase biosynthetic process (GO:0009113)3.67901846
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.67734379
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.67734379
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.67734379
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.62745563
76spliceosomal snRNP assembly (GO:0000387)3.60698398
77rRNA processing (GO:0006364)3.59998378
78signal transduction involved in DNA integrity checkpoint (GO:0072401)3.58119358
79signal transduction involved in DNA damage checkpoint (GO:0072422)3.58119358
80establishment of viral latency (GO:0019043)3.55925234
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.55049801
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.53107823
83UTP biosynthetic process (GO:0006228)3.52816188
84hydrogen ion transmembrane transport (GO:1902600)3.51723235
85rRNA methylation (GO:0031167)3.50896126
86ribosome biogenesis (GO:0042254)3.48596077
87ribonucleoside triphosphate biosynthetic process (GO:0009201)3.47999653
88nucleobase biosynthetic process (GO:0046112)3.47226993
89rRNA metabolic process (GO:0016072)3.47040182
90transcription elongation from RNA polymerase I promoter (GO:0006362)3.46816329
91regulation of ubiquitin-protein transferase activity (GO:0051438)3.44184099
92positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.43939853
93establishment of integrated proviral latency (GO:0075713)3.42910626
94deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40544905
95formation of translation preinitiation complex (GO:0001731)3.38699006
96mitotic metaphase plate congression (GO:0007080)3.38466645
97telomere maintenance via semi-conservative replication (GO:0032201)3.34714694
98regulation of ligase activity (GO:0051340)3.32659783
99DNA damage response, detection of DNA damage (GO:0042769)3.32312525
100DNA strand elongation involved in DNA replication (GO:0006271)3.31706159
101positive regulation of ligase activity (GO:0051351)3.30648128
102histone exchange (GO:0043486)3.29844470
103peptidyl-histidine modification (GO:0018202)3.28570603
104termination of RNA polymerase I transcription (GO:0006363)3.26734136
105protein complex disassembly (GO:0043241)3.26371721
106maturation of 5.8S rRNA (GO:0000460)3.26085253
107kinetochore assembly (GO:0051382)3.25988704
108DNA replication checkpoint (GO:0000076)3.25739706
109iron-sulfur cluster assembly (GO:0016226)3.25645350
110metallo-sulfur cluster assembly (GO:0031163)3.25645350
111antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.25512772
112transcription from RNA polymerase I promoter (GO:0006360)3.23456497
113regulation of cellular amine metabolic process (GO:0033238)3.22916430
114amino acid salvage (GO:0043102)3.22076000
115L-methionine biosynthetic process (GO:0071265)3.22076000
116RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21744354
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21744354
118kinetochore organization (GO:0051383)3.21014901
119DNA strand elongation (GO:0022616)3.17625271
120* mitochondrial transport (GO:0006839)3.16496045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.08001026
2* GABP_17652178_ChIP-ChIP_JURKAT_Human4.53977169
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.53835573
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.44625611
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.36449211
6* ETS1_20019798_ChIP-Seq_JURKAT_Human4.01540525
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.01146314
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.00379121
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71673424
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.59812009
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.52669089
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.52644951
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.28523864
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.27423550
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.12818628
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.96210703
17E2F7_22180533_ChIP-Seq_HELA_Human2.95406371
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88389278
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86625992
20* VDR_23849224_ChIP-Seq_CD4+_Human2.72428824
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.59699783
22* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.58344692
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.58183108
24DCP1A_22483619_ChIP-Seq_HELA_Human2.47495732
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.47227089
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41310337
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.34185433
28XRN2_22483619_ChIP-Seq_HELA_Human2.31611665
29* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.21142743
30FOXP3_21729870_ChIP-Seq_TREG_Human2.15334083
31ELK1_19687146_ChIP-ChIP_HELA_Human2.11987082
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11786532
33TTF2_22483619_ChIP-Seq_HELA_Human2.11220455
34* GABP_19822575_ChIP-Seq_HepG2_Human2.10433871
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01940535
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.99093459
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92851452
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89331546
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81466197
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73614762
41* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68364849
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67497501
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67395380
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61110225
45* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60024441
46* ELK1_22589737_ChIP-Seq_MCF10A_Human1.52823753
47* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52554316
48* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46525366
49* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43060134
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42424738
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41474834
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38896960
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38626419
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32672956
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32060258
56IRF1_19129219_ChIP-ChIP_H3396_Human1.30341802
57MYC_18940864_ChIP-ChIP_HL60_Human1.30040458
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26215573
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25942849
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23891223
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18892293
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18316918
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17933627
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17805549
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.16732457
66* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10399037
67CIITA_25753668_ChIP-Seq_RAJI_Human1.09190414
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07059322
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03913430
70* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03028916
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.01579466
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96671356
73KDM5A_27292631_Chip-Seq_BREAST_Human0.95223780
74SOX2_16153702_ChIP-ChIP_HESCs_Human0.93868065
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93139795
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90126902
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89582700
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89448538
79E2F1_21310950_ChIP-Seq_MCF-7_Human0.86970456
80BP1_19119308_ChIP-ChIP_Hs578T_Human0.86733291
81AR_21909140_ChIP-Seq_LNCAP_Human0.86482801
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80205144
83STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79966639
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.78886426
85* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78617184
86SOX17_20123909_ChIP-Seq_XEN_Mouse0.77884477
87SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76668488
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76484704
89EWS_26573619_Chip-Seq_HEK293_Human0.75941189
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75538932
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74598893
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74594562
93* ELF5_23300383_ChIP-Seq_T47D_Human0.74565009
94* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73640998
95TAF15_26573619_Chip-Seq_HEK293_Human0.73535759
96* FOXP1_21924763_ChIP-Seq_HESCs_Human0.73516382
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73329326
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72093164
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71771724
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71205657
101ZNF274_21170338_ChIP-Seq_K562_Hela0.71199974
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69031872
103PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69004721
104VDR_22108803_ChIP-Seq_LS180_Human0.68999899
105FUS_26573619_Chip-Seq_HEK293_Human0.68991680
106YY1_22570637_ChIP-Seq_MALME-3M_Human0.67162112
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.66811404
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.65780165
109OCT4_18692474_ChIP-Seq_MEFs_Mouse0.64286076
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.62606340
111* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.62348958
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.61704663
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.61034162
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.60978829
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.60154599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.74726752
2MP0009379_abnormal_foot_pigmentation3.52474471
3MP0006036_abnormal_mitochondrial_physio3.17805871
4MP0001529_abnormal_vocalization3.10511558
5MP0004957_abnormal_blastocyst_morpholog2.94209010
6MP0003880_abnormal_central_pattern2.91582035
7MP0006035_abnormal_mitochondrial_morpho2.78624080
8MP0002837_dystrophic_cardiac_calcinosis2.77158020
9MP0003646_muscle_fatigue2.76978197
10MP0001905_abnormal_dopamine_level2.50208759
11MP0003718_maternal_effect2.20647939
12MP0008058_abnormal_DNA_repair2.14568577
13MP0003941_abnormal_skin_development2.07474301
14MP0010094_abnormal_chromosome_stability2.05036731
15MP0008057_abnormal_DNA_replication1.98257031
16MP0006292_abnormal_olfactory_placode1.95210700
17MP0003077_abnormal_cell_cycle1.92615057
18MP0006276_abnormal_autonomic_nervous1.91805671
19MP0004215_abnormal_myocardial_fiber1.87654458
20MP0003806_abnormal_nucleotide_metabolis1.86969076
21MP0003111_abnormal_nucleus_morphology1.83688546
22MP0003786_premature_aging1.83225934
23MP0008932_abnormal_embryonic_tissue1.82559428
24MP0010030_abnormal_orbit_morphology1.81622782
25MP0002638_abnormal_pupillary_reflex1.80610290
26MP0003186_abnormal_redox_activity1.80187075
27MP0004147_increased_porphyrin_level1.80172743
28MP0004142_abnormal_muscle_tone1.74795064
29MP0002736_abnormal_nociception_after1.73295238
30MP0001986_abnormal_taste_sensitivity1.72752263
31MP0008789_abnormal_olfactory_epithelium1.71904761
32MP0001188_hyperpigmentation1.70403838
33MP0004084_abnormal_cardiac_muscle1.70381385
34MP0000749_muscle_degeneration1.65005819
35MP0001968_abnormal_touch/_nociception1.60135851
36MP0006072_abnormal_retinal_apoptosis1.55646445
37MP0001293_anophthalmia1.55167586
38MP0005084_abnormal_gallbladder_morpholo1.54800879
39MP0002163_abnormal_gland_morphology1.50553127
40MP0003011_delayed_dark_adaptation1.50372253
41MP0002277_abnormal_respiratory_mucosa1.48615651
42MP0000751_myopathy1.40767454
43MP0004036_abnormal_muscle_relaxation1.40166127
44MP0009046_muscle_twitch1.39994919
45MP0003221_abnormal_cardiomyocyte_apopto1.39875035
46MP0003123_paternal_imprinting1.37872837
47MP0008877_abnormal_DNA_methylation1.37798002
48MP0005330_cardiomyopathy1.37788880
49MP0005408_hypopigmentation1.36222172
50MP0002132_abnormal_respiratory_system1.30238076
51MP0003656_abnormal_erythrocyte_physiolo1.28846626
52MP0002822_catalepsy1.28426539
53MP0002272_abnormal_nervous_system1.28117886
54MP0002735_abnormal_chemical_nociception1.26813318
55MP0008995_early_reproductive_senescence1.25568461
56MP0009745_abnormal_behavioral_response1.25562783
57MP0008875_abnormal_xenobiotic_pharmacok1.25126793
58MP0001727_abnormal_embryo_implantation1.25036172
59MP0004145_abnormal_muscle_electrophysio1.24192164
60MP0002102_abnormal_ear_morphology1.23894092
61MP0001764_abnormal_homeostasis1.20538595
62MP0000350_abnormal_cell_proliferation1.20305526
63MP0008260_abnormal_autophagy1.19701885
64MP0001440_abnormal_grooming_behavior1.18120175
65MP0009697_abnormal_copulation1.17574311
66MP0002734_abnormal_mechanical_nocicepti1.16428402
67MP0005266_abnormal_metabolism1.13749055
68MP0000358_abnormal_cell_content/1.13545727
69MP0002210_abnormal_sex_determination1.13071238
70MP0009333_abnormal_splenocyte_physiolog1.08503005
71MP0002064_seizures1.08003519
72MP0005379_endocrine/exocrine_gland_phen1.07770409
73MP0003315_abnormal_perineum_morphology1.06005862
74MP0005394_taste/olfaction_phenotype1.05682641
75MP0005499_abnormal_olfactory_system1.05682641
76MP0005423_abnormal_somatic_nervous1.04464850
77MP0001697_abnormal_embryo_size1.03735114
78MP0002396_abnormal_hematopoietic_system1.02570990
79MP0003137_abnormal_impulse_conducting1.00843279
80MP0005386_behavior/neurological_phenoty0.99788270
81MP0004924_abnormal_behavior0.99788270
82MP0002332_abnormal_exercise_endurance0.99761165
83MP0003567_abnormal_fetal_cardiomyocyte0.99654428
84MP0004133_heterotaxia0.99123281
85MP0000372_irregular_coat_pigmentation0.98618115
86MP0002572_abnormal_emotion/affect_behav0.98256020
87MP0002876_abnormal_thyroid_physiology0.97920217
88MP0001501_abnormal_sleep_pattern0.95047466
89MP0005389_reproductive_system_phenotype0.94461439
90MP0001346_abnormal_lacrimal_gland0.93852399
91MP0003136_yellow_coat_color0.93760366
92MP0003635_abnormal_synaptic_transmissio0.93140182
93MP0001970_abnormal_pain_threshold0.92390248
94MP0002127_abnormal_cardiovascular_syste0.92040453
95MP0001853_heart_inflammation0.91654045
96MP0008007_abnormal_cellular_replicative0.90839046
97MP0002938_white_spotting0.90716259
98MP0008775_abnormal_heart_ventricle0.90684933
99MP0001929_abnormal_gametogenesis0.89427837
100MP0001485_abnormal_pinna_reflex0.87269876
101MP0002095_abnormal_skin_pigmentation0.86109122
102MP0001919_abnormal_reproductive_system0.86056189
103MP0002106_abnormal_muscle_physiology0.85899386
104MP0001145_abnormal_male_reproductive0.84988940
105MP0000653_abnormal_sex_gland0.84305860
106MP0000049_abnormal_middle_ear0.83956522
107MP0003121_genomic_imprinting0.82810860
108MP0000631_abnormal_neuroendocrine_gland0.82736822
109MP0008872_abnormal_physiological_respon0.82508021
110MP0005409_darkened_coat_color0.82495197
111MP0001730_embryonic_growth_arrest0.82466593
112MP0004484_altered_response_of0.82081042
113MP0002067_abnormal_sensory_capabilities0.81200381
114MP0002733_abnormal_thermal_nociception0.80661010
115MP0002234_abnormal_pharynx_morphology0.80300915
116MP0000750_abnormal_muscle_regeneration0.79474828
117MP0001881_abnormal_mammary_gland0.79441002
118MP0002080_prenatal_lethality0.78278129
119MP0002160_abnormal_reproductive_system0.77141943
120MP0002090_abnormal_vision0.76182477
121MP0002972_abnormal_cardiac_muscle0.75859510
122MP0002085_abnormal_embryonic_tissue0.75722792
123MP0003195_calcinosis0.75328616
124MP0005332_abnormal_amino_acid0.75114508
125MP0000647_abnormal_sebaceous_gland0.75085863
126MP0005380_embryogenesis_phenotype0.74890461
127MP0001672_abnormal_embryogenesis/_devel0.74890461
128MP0000747_muscle_weakness0.74667732
129MP0005376_homeostasis/metabolism_phenot0.74210756
130MP0002184_abnormal_innervation0.73812478
131MP0000313_abnormal_cell_death0.72782100
132MP0002751_abnormal_autonomic_nervous0.71827579
133MP0003879_abnormal_hair_cell0.71672620
134MP0001984_abnormal_olfaction0.71312426
135MP0005636_abnormal_mineral_homeostasis0.70718697
136MP0002233_abnormal_nose_morphology0.70322986
137MP0005075_abnormal_melanosome_morpholog0.70044785
138MP0002063_abnormal_learning/memory/cond0.69575770
139MP0005253_abnormal_eye_physiology0.69575170
140MP0004270_analgesia0.68142082
141MP0003938_abnormal_ear_development0.67087703
142MP0001119_abnormal_female_reproductive0.66464140
143MP0005551_abnormal_eye_electrophysiolog0.65426094
144MP0003937_abnormal_limbs/digits/tail_de0.65351362
145MP0005410_abnormal_fertilization0.64693181
146MP0005395_other_phenotype0.60716593
147MP0002019_abnormal_tumor_incidence0.60495261
148MP0001286_abnormal_eye_development0.60333209

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.06147562
2Abnormal mitochondria in muscle tissue (HP:0008316)6.42923525
3Mitochondrial inheritance (HP:0001427)6.37971461
4Progressive macrocephaly (HP:0004481)5.85167742
5Acute encephalopathy (HP:0006846)5.72895643
6Increased CSF lactate (HP:0002490)5.72776723
7Hepatocellular necrosis (HP:0001404)5.69225520
8Increased hepatocellular lipid droplets (HP:0006565)5.35672104
9Hepatic necrosis (HP:0002605)4.93574070
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.82070064
11Abnormality of cells of the erythroid lineage (HP:0012130)4.79690392
12Lipid accumulation in hepatocytes (HP:0006561)4.76339742
13Abnormal number of erythroid precursors (HP:0012131)4.60046737
14Abnormality of glycolysis (HP:0004366)4.33307433
15Increased serum pyruvate (HP:0003542)4.33307433
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.27876690
17Renal Fanconi syndrome (HP:0001994)4.19274426
18Increased intramyocellular lipid droplets (HP:0012240)4.14034518
19Increased serum lactate (HP:0002151)4.11485383
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.10486072
21Decreased activity of mitochondrial respiratory chain (HP:0008972)4.10486072
22Cerebral edema (HP:0002181)4.06275348
233-Methylglutaconic aciduria (HP:0003535)4.05128885
24Exercise intolerance (HP:0003546)4.04448610
25Lactic acidosis (HP:0003128)3.99015693
26Respiratory failure (HP:0002878)3.80574332
27Exertional dyspnea (HP:0002875)3.66803091
28Increased muscle lipid content (HP:0009058)3.49338550
29Respiratory difficulties (HP:0002880)3.45863144
30Optic disc pallor (HP:0000543)3.40658399
31Leukodystrophy (HP:0002415)3.27442304
32Reticulocytopenia (HP:0001896)3.20127387
33Birth length less than 3rd percentile (HP:0003561)2.97032052
34Macrocytic anemia (HP:0001972)2.92689274
35Cerebral hypomyelination (HP:0006808)2.91415959
36CNS demyelination (HP:0007305)2.82486795
37Colon cancer (HP:0003003)2.75580445
38Aplastic anemia (HP:0001915)2.74430625
39Emotional lability (HP:0000712)2.68477972
40Pallor (HP:0000980)2.66096417
41Microvesicular hepatic steatosis (HP:0001414)2.66068161
42Oral leukoplakia (HP:0002745)2.63726031
43Abnormality of alanine metabolism (HP:0010916)2.60169846
44Hyperalaninemia (HP:0003348)2.60169846
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60169846
46Abnormality of the anterior horn cell (HP:0006802)2.56987781
47Degeneration of anterior horn cells (HP:0002398)2.56987781
48Abnormality of renal resorption (HP:0011038)2.54252334
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.52785230
50Congenital, generalized hypertrichosis (HP:0004540)2.39514058
51Lethargy (HP:0001254)2.33490198
52Meckel diverticulum (HP:0002245)2.31602939
53Methylmalonic acidemia (HP:0002912)2.26286325
54Delusions (HP:0000746)2.25106765
55Hyperglycinemia (HP:0002154)2.23990917
56Breast hypoplasia (HP:0003187)2.21996021
57X-linked dominant inheritance (HP:0001423)2.20687698
58Abnormality of methionine metabolism (HP:0010901)2.20620211
59Abnormality of the ileum (HP:0001549)2.19073081
60Rough bone trabeculation (HP:0100670)2.18692026
61Hyperphosphaturia (HP:0003109)2.14568974
62Glycosuria (HP:0003076)2.11851502
63Abnormality of urine glucose concentration (HP:0011016)2.11851502
64Type I transferrin isoform profile (HP:0003642)2.08922215
65Gliosis (HP:0002171)2.08280684
66Abnormality of serum amino acid levels (HP:0003112)2.04410007
67Cleft eyelid (HP:0000625)2.02029857
68Neuroendocrine neoplasm (HP:0100634)2.01111351
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.00065768
70Unsteady gait (HP:0002317)1.99721512
71Abnormality of the labia minora (HP:0012880)1.99631800
72Irregular epiphyses (HP:0010582)1.93355695
73Carpal bone hypoplasia (HP:0001498)1.92173088
74Abnormal lung lobation (HP:0002101)1.92108410
75Blindness (HP:0000618)1.91539402
76Sparse eyelashes (HP:0000653)1.91121695
77Reduced antithrombin III activity (HP:0001976)1.90454766
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89112796
79CNS hypomyelination (HP:0003429)1.87139277
80Poor suck (HP:0002033)1.86131866
81Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84647185
82Generalized aminoaciduria (HP:0002909)1.83879805
83Pheochromocytoma (HP:0002666)1.83004926
84Hypothermia (HP:0002045)1.81313617
85Ragged-red muscle fibers (HP:0003200)1.80472429
86Progressive muscle weakness (HP:0003323)1.79185402
87Secondary amenorrhea (HP:0000869)1.79112198
88Absent thumb (HP:0009777)1.78470860
89Aplasia/hypoplasia of the uterus (HP:0008684)1.78303314
90Testicular atrophy (HP:0000029)1.77978877
91Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77772681
92Pancytopenia (HP:0001876)1.76118864
93Progressive external ophthalmoplegia (HP:0000590)1.75738162
94Abnormality of chromosome stability (HP:0003220)1.75048899
95Type 2 muscle fiber atrophy (HP:0003554)1.75031392
96Amniotic constriction ring (HP:0009775)1.73825423
97Abnormality of placental membranes (HP:0011409)1.73825423
98Abnormality of midbrain morphology (HP:0002418)1.73308437
99Molar tooth sign on MRI (HP:0002419)1.73308437
100Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72443067
101Sclerocornea (HP:0000647)1.71158263
102Megaloblastic anemia (HP:0001889)1.70496394
103Abnormal pupillary function (HP:0007686)1.69712071
104Abnormal trabecular bone morphology (HP:0100671)1.69550132
105Renal tubular dysfunction (HP:0000124)1.68734329
106Focal motor seizures (HP:0011153)1.68724278
107Abnormal urine phosphate concentration (HP:0012599)1.68346456
108Septo-optic dysplasia (HP:0100842)1.67858722
109Palpitations (HP:0001962)1.67042199
110Absent septum pellucidum (HP:0001331)1.65887233
111Muscle fiber atrophy (HP:0100295)1.65777462
112True hermaphroditism (HP:0010459)1.64002843
113Abnormality of dicarboxylic acid metabolism (HP:0010995)1.63915715
114Dicarboxylic aciduria (HP:0003215)1.63915715
115Triphalangeal thumb (HP:0001199)1.63005471
116Premature graying of hair (HP:0002216)1.58852566
117Pancreatic fibrosis (HP:0100732)1.58148578
118Multiple enchondromatosis (HP:0005701)1.56227836
119Abnormality of the preputium (HP:0100587)1.55847707
120Cellular immunodeficiency (HP:0005374)1.51903253
121Postnatal microcephaly (HP:0005484)1.50720418
122Abnormal protein glycosylation (HP:0012346)1.49480968
123Abnormal glycosylation (HP:0012345)1.49480968
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.49480968
125Abnormal protein N-linked glycosylation (HP:0012347)1.49480968
126Pancreatic cysts (HP:0001737)1.49457085
127Horseshoe kidney (HP:0000085)1.48794264
128Methylmalonic aciduria (HP:0012120)1.48153167
129Muscle hypertrophy of the lower extremities (HP:0008968)1.47886947
130Microretrognathia (HP:0000308)1.47801779
131Vomiting (HP:0002013)1.42847935
132Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.42520761
133Death in infancy (HP:0001522)1.41878745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.31279763
2STK164.66428127
3NME24.13220538
4BUB14.09597078
5WEE13.37035099
6NME13.04345419
7EIF2AK12.79522574
8MAP3K122.68778066
9VRK12.41630658
10TSSK62.27299398
11SRPK12.24584284
12MYLK1.91737320
13PNCK1.91692921
14NUAK11.89955979
15PIM21.86417549
16MUSK1.83696503
17TAF11.83579657
18CASK1.80500368
19EIF2AK31.78797168
20PLK41.69561129
21OBSCN1.55934071
22CDK191.54177265
23BRSK21.47630258
24ACVR1B1.47146415
25ARAF1.46707944
26PDK21.45213580
27TNIK1.42500704
28BMPR1B1.37708682
29TRIM281.33701762
30CCNB11.33697108
31MAP2K71.30631992
32GRK71.30610591
33GRK51.20284979
34PLK31.18403544
35DYRK21.17677460
36MKNK11.14192239
37ZAK1.13537786
38MKNK21.11667291
39MAP4K21.11657440
40BRAF1.06443583
41TLK11.03197428
42ADRBK21.02728752
43WNK31.02566418
44DAPK11.02551021
45PLK10.99767165
46PLK20.97272154
47AURKA0.94085060
48MST40.92698115
49CDC70.92028917
50PAK40.91875069
51BRSK10.91481010
52AKT30.90830534
53PBK0.90673158
54MAP3K110.89114850
55DYRK30.88875118
56MAPK130.88506977
57ABL20.87204301
58NEK10.85496413
59STK40.84739605
60NEK20.82905714
61BCKDK0.82091278
62STK240.81580263
63MARK10.79060763
64SIK30.78823196
65EIF2AK20.76923187
66PDK30.75600078
67PDK40.75600078
68CSNK1G30.75590565
69CSNK1A1L0.74858367
70CSNK2A10.71818084
71CSNK2A20.70656124
72AURKB0.69115024
73CDK80.68915968
74ILK0.63133826
75DAPK30.57834385
76LIMK10.57588950
77MINK10.53754038
78OXSR10.52439967
79CHEK10.51692539
80MAP3K40.49816768
81CDK70.49570331
82RPS6KA40.49554621
83PRKCG0.48834347
84ADRBK10.48424627
85RPS6KB20.48184116
86KDR0.47698847
87TESK20.47370304
88TTK0.47012261
89GRK10.46352987
90PINK10.46195455
91TGFBR10.45930566
92CAMK2B0.45153867
93CAMK2D0.44127399
94CHEK20.43869228
95RPS6KA50.42909073
96MAPKAPK50.42264759
97PRKCI0.42235404
98PAK10.42205428
99MAP3K80.42091296
100TESK10.41051177
101STK100.40596230
102PASK0.40371958
103LRRK20.40129300
104ATM0.39740499
105ALK0.39319556
106CAMK2A0.38652049
107CAMK2G0.38634654
108RIPK40.38260381
109ATR0.37734787
110BCR0.36539133
111SCYL20.33590580
112BRD40.32707427
113CSNK1G10.32516418
114CSNK1E0.32442893
115CAMK10.32392286
116INSRR0.32364361
117CSNK1G20.32056469
118MAP2K40.31962716
119CDK180.31365690
120CSNK1A10.31302285
121BMPR20.31088665
122PRKACA0.30512509
123CDK140.30222421
124MAPKAPK30.30105643
125CDK11A0.30072383
126SMG10.25632066
127CDK10.24593284
128PHKG10.24392438
129PHKG20.24392438
130ERBB40.18494904
131CDK20.17820883
132WNK40.16657182

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.10919806
2Ribosome_Homo sapiens_hsa030104.73177598
3Proteasome_Homo sapiens_hsa030504.68594879
4Parkinsons disease_Homo sapiens_hsa050124.56162399
5RNA polymerase_Homo sapiens_hsa030204.11770372
6Huntingtons disease_Homo sapiens_hsa050163.41885161
7Alzheimers disease_Homo sapiens_hsa050103.19891650
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.66319629
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65086671
10DNA replication_Homo sapiens_hsa030302.60729756
11Pyrimidine metabolism_Homo sapiens_hsa002402.53413625
12Cardiac muscle contraction_Homo sapiens_hsa042602.23041613
13Mismatch repair_Homo sapiens_hsa034302.17671557
14Spliceosome_Homo sapiens_hsa030402.05061456
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97758398
16Protein export_Homo sapiens_hsa030601.92691739
17Nucleotide excision repair_Homo sapiens_hsa034201.83899503
18Homologous recombination_Homo sapiens_hsa034401.78940526
19RNA transport_Homo sapiens_hsa030131.69369053
20Purine metabolism_Homo sapiens_hsa002301.53357640
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47601365
22Basal transcription factors_Homo sapiens_hsa030221.44990614
23Base excision repair_Homo sapiens_hsa034101.44930045
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31616226
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30544067
26RNA degradation_Homo sapiens_hsa030181.24909387
27Sulfur relay system_Homo sapiens_hsa041221.22022869
28Collecting duct acid secretion_Homo sapiens_hsa049661.21473635
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.12706637
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06131922
31Fanconi anemia pathway_Homo sapiens_hsa034601.00748333
32Vitamin B6 metabolism_Homo sapiens_hsa007500.92215872
33Non-homologous end-joining_Homo sapiens_hsa034500.91254941
34Folate biosynthesis_Homo sapiens_hsa007900.87581698
35Metabolic pathways_Homo sapiens_hsa011000.85059103
36Pyruvate metabolism_Homo sapiens_hsa006200.84753702
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84570234
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83418650
39Nicotine addiction_Homo sapiens_hsa050330.81413884
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81240407
41Carbon metabolism_Homo sapiens_hsa012000.81189149
42Cell cycle_Homo sapiens_hsa041100.77783732
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74865817
44Epstein-Barr virus infection_Homo sapiens_hsa051690.74002047
45Steroid biosynthesis_Homo sapiens_hsa001000.70944083
46One carbon pool by folate_Homo sapiens_hsa006700.68560382
47Fatty acid elongation_Homo sapiens_hsa000620.68523227
48Glutathione metabolism_Homo sapiens_hsa004800.66866924
49Selenocompound metabolism_Homo sapiens_hsa004500.66835738
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65939954
51Vibrio cholerae infection_Homo sapiens_hsa051100.61561786
52Pentose phosphate pathway_Homo sapiens_hsa000300.61135086
53Biosynthesis of amino acids_Homo sapiens_hsa012300.59068534
54Regulation of autophagy_Homo sapiens_hsa041400.54571725
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54510683
56Sulfur metabolism_Homo sapiens_hsa009200.52828665
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50631409
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46155704
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.45150262
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44304608
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43626499
62Synaptic vesicle cycle_Homo sapiens_hsa047210.42669934
63Fructose and mannose metabolism_Homo sapiens_hsa000510.41620929
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39490833
65Rheumatoid arthritis_Homo sapiens_hsa053230.39452074
66Propanoate metabolism_Homo sapiens_hsa006400.38930312
67Arachidonic acid metabolism_Homo sapiens_hsa005900.38573069
68Oocyte meiosis_Homo sapiens_hsa041140.37282158
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37153691
70Tryptophan metabolism_Homo sapiens_hsa003800.36662506
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36524249
72Phenylalanine metabolism_Homo sapiens_hsa003600.36493548
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36485416
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33963491
75p53 signaling pathway_Homo sapiens_hsa041150.33382378
76Tyrosine metabolism_Homo sapiens_hsa003500.31231613
77Caffeine metabolism_Homo sapiens_hsa002320.30950471
78Arginine and proline metabolism_Homo sapiens_hsa003300.29859979
79beta-Alanine metabolism_Homo sapiens_hsa004100.29585729
80Chemical carcinogenesis_Homo sapiens_hsa052040.29555838
81mRNA surveillance pathway_Homo sapiens_hsa030150.29503855
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.28776186
83Fatty acid degradation_Homo sapiens_hsa000710.27781344
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27351325
85Galactose metabolism_Homo sapiens_hsa000520.26942780
86Systemic lupus erythematosus_Homo sapiens_hsa053220.26125392
87Vitamin digestion and absorption_Homo sapiens_hsa049770.24143921
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23928788
89Fatty acid metabolism_Homo sapiens_hsa012120.23922280
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23254975
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22882570
92Phototransduction_Homo sapiens_hsa047440.21174929
93Serotonergic synapse_Homo sapiens_hsa047260.21174685
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.20814360
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.19870524
96Retinol metabolism_Homo sapiens_hsa008300.16633918
97Phagosome_Homo sapiens_hsa041450.14974937
98N-Glycan biosynthesis_Homo sapiens_hsa005100.14764176
99Taste transduction_Homo sapiens_hsa047420.14525605
100Peroxisome_Homo sapiens_hsa041460.13250257
101Alcoholism_Homo sapiens_hsa050340.12875528
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.10946166
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.10488876
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09367193
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.09300002
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08526279
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08513627
108Asthma_Homo sapiens_hsa053100.08104096
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.08009652
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07787377
111Calcium signaling pathway_Homo sapiens_hsa040200.04945723
112Fat digestion and absorption_Homo sapiens_hsa049750.04904525
113Amphetamine addiction_Homo sapiens_hsa050310.04260037
114Linoleic acid metabolism_Homo sapiens_hsa005910.04068327
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.04015361
116Type I diabetes mellitus_Homo sapiens_hsa049400.02777471
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.02629831
118GABAergic synapse_Homo sapiens_hsa047270.02467209
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.02248008
120Legionellosis_Homo sapiens_hsa051340.01965604
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914-0.0067945
122Butanoate metabolism_Homo sapiens_hsa00650-0.0063037

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