TIMD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, alternative pathway (GO:0006957)9.54385789
2pyrimidine ribonucleoside catabolic process (GO:0046133)9.39226126
3regulation of apoptotic cell clearance (GO:2000425)9.28362826
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.77204914
5DNA deamination (GO:0045006)8.30149048
6regulation of integrin activation (GO:0033623)7.55146423
7regulation of complement activation (GO:0030449)6.55224111
8regulation of protein activation cascade (GO:2000257)6.47348698
9complement activation (GO:0006956)6.35382135
10regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)6.30040030
11opsonization (GO:0008228)6.26680646
12mannose metabolic process (GO:0006013)6.05517616
13cellular response to interleukin-15 (GO:0071350)6.00621997
14eosinophil chemotaxis (GO:0048245)5.95702965
15eosinophil migration (GO:0072677)5.90522925
16apoptotic cell clearance (GO:0043277)5.74910247
17lipoxygenase pathway (GO:0019372)5.61763563
18citrulline biosynthetic process (GO:0019240)5.50264575
19regulation of humoral immune response (GO:0002920)5.38674311
20negative regulation by host of viral transcription (GO:0043922)5.35277621
21complement activation, classical pathway (GO:0006958)5.32272207
22germinal center formation (GO:0002467)5.24976822
23protein carboxylation (GO:0018214)5.18243674
24peptidyl-glutamic acid carboxylation (GO:0017187)5.18243674
25positive regulation of calcium-mediated signaling (GO:0050850)5.17846881
26protein activation cascade (GO:0072376)5.11272512
27positive regulation of gamma-delta T cell activation (GO:0046645)5.06292342
28response to interleukin-15 (GO:0070672)5.01083837
29cytolysis (GO:0019835)4.93700092
30endothelial cell chemotaxis (GO:0035767)4.91641070
31positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.83320541
32positive regulation of natural killer cell mediated immunity (GO:0002717)4.82165376
33regulation of lymphocyte chemotaxis (GO:1901623)4.81624781
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.77854133
35T cell migration (GO:0072678)4.69119129
36regulation of endothelial cell chemotaxis (GO:2001026)4.65401759
37pyrimidine nucleoside catabolic process (GO:0046135)4.58259693
38positive thymic T cell selection (GO:0045059)4.51974122
39positive regulation of interleukin-8 secretion (GO:2000484)4.26971654
40positive regulation of B cell differentiation (GO:0045579)4.23639373
41positive T cell selection (GO:0043368)4.23528986
42phospholipid efflux (GO:0033700)4.22849849
43Arp2/3 complex-mediated actin nucleation (GO:0034314)4.22398188
44regulation of interleukin-12 biosynthetic process (GO:0045075)4.20624561
45macrophage chemotaxis (GO:0048246)4.19075908
46plasma lipoprotein particle clearance (GO:0034381)4.18939046
47regulation of natural killer cell mediated immunity (GO:0002715)4.17041038
48regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.17041038
49L-phenylalanine catabolic process (GO:0006559)4.13102835
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.13102835
51regulation of macrophage chemotaxis (GO:0010758)4.10983854
52detection of molecule of bacterial origin (GO:0032490)4.09987569
53positive regulation of lymphocyte migration (GO:2000403)4.01390978
54negative T cell selection (GO:0043383)4.00592507
55positive regulation of T cell chemotaxis (GO:0010820)3.98857307
56regulation of T cell chemotaxis (GO:0010819)3.98857307
57regulation of gamma-delta T cell differentiation (GO:0045586)3.98421434
58L-phenylalanine metabolic process (GO:0006558)3.98240575
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.98240575
60negative regulation of viral genome replication (GO:0045071)3.96404310
61disruption of cells of other organism (GO:0044364)3.95274264
62killing of cells of other organism (GO:0031640)3.95274264
63urea metabolic process (GO:0019627)3.93668362
64urea cycle (GO:0000050)3.93668362
65granulocyte activation (GO:0036230)3.93489968
66cellular extravasation (GO:0045123)3.92856033
67negative regulation of fibrinolysis (GO:0051918)3.90751762
68regulation of cholesterol esterification (GO:0010872)3.90724746
69high-density lipoprotein particle remodeling (GO:0034375)3.89230226
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88958095
71regulation of chronic inflammatory response (GO:0002676)3.85204101
72regulation of activation of Janus kinase activity (GO:0010533)3.84522547
73thymic T cell selection (GO:0045061)3.83462477
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.81919957
75positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.81489590
76regulation of calcium-mediated signaling (GO:0050848)3.78679152
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77049988
78alpha-linolenic acid metabolic process (GO:0036109)3.76542497
79citrulline metabolic process (GO:0000052)3.74281709
80aromatic amino acid family catabolic process (GO:0009074)3.73467336
81long-chain fatty acid biosynthetic process (GO:0042759)3.72971211
82positive regulation of blood coagulation (GO:0030194)3.69950166
83positive regulation of hemostasis (GO:1900048)3.69950166
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.69027218
85actin nucleation (GO:0045010)3.68344290
86reverse cholesterol transport (GO:0043691)3.67631822
87negative regulation of viral transcription (GO:0032897)3.67462621
88production of molecular mediator involved in inflammatory response (GO:0002532)3.64503810
89negative regulation of granulocyte differentiation (GO:0030853)3.64388733
90positive regulation of coagulation (GO:0050820)3.62864970
91nitrogen cycle metabolic process (GO:0071941)3.60796687
92regulation of B cell differentiation (GO:0045577)3.60231011
93negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.60144971
94negative regulation of cell killing (GO:0031342)3.60144971
95positive regulation of cell adhesion mediated by integrin (GO:0033630)3.56422935
96regulation of fibrinolysis (GO:0051917)3.56301137
97negative regulation of T cell apoptotic process (GO:0070233)3.50485321
98regulation of gamma-delta T cell activation (GO:0046643)3.49249143
99positive regulation of cell killing (GO:0031343)3.47762106
100positive regulation of Rap GTPase activity (GO:0032854)3.46977304
101bile acid biosynthetic process (GO:0006699)3.44467433
102protoporphyrinogen IX biosynthetic process (GO:0006782)3.42641137
103defense response to fungus (GO:0050832)3.42282433
104regulation of leukocyte mediated cytotoxicity (GO:0001910)3.42094506
105T cell selection (GO:0045058)3.41229103
106innate immune response in mucosa (GO:0002227)3.41073376
107lymphocyte chemotaxis (GO:0048247)3.40512556
108fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.39227596
109cholesterol efflux (GO:0033344)3.39068609
110positive regulation of defense response to virus by host (GO:0002230)3.38949299
111regulation of interleukin-2 biosynthetic process (GO:0045076)3.38512102
112negative thymic T cell selection (GO:0045060)3.36622956
113regulation of cholesterol storage (GO:0010885)3.35627664
114cellular defense response (GO:0006968)3.34066899
115plasma lipoprotein particle assembly (GO:0034377)3.33177093
116positive regulation of monocyte chemotaxis (GO:0090026)3.32303220
117indole-containing compound catabolic process (GO:0042436)3.31949027
118indolalkylamine catabolic process (GO:0046218)3.31949027
119tryptophan catabolic process (GO:0006569)3.31949027
120plasma lipoprotein particle remodeling (GO:0034369)3.31628791
121protein-lipid complex remodeling (GO:0034368)3.31628791
122macromolecular complex remodeling (GO:0034367)3.31628791
123low-density lipoprotein particle remodeling (GO:0034374)3.31626870
124positive regulation of tolerance induction (GO:0002645)3.30204175
125negative regulation of interleukin-12 production (GO:0032695)3.30142945
126glyoxylate metabolic process (GO:0046487)3.30087107
127regulation of natural killer cell differentiation (GO:0032823)3.29924903
128kynurenine metabolic process (GO:0070189)3.29159354
129protein-lipid complex assembly (GO:0065005)3.27851835
130regulation of T cell tolerance induction (GO:0002664)3.26754477
131fibrinolysis (GO:0042730)3.26576634
132phosphatidylethanolamine biosynthetic process (GO:0006646)3.23456142
133lymphocyte costimulation (GO:0031294)3.22768604
134regulation of phagocytosis (GO:0050764)3.22272799
135negative regulation of sterol transport (GO:0032372)3.19208484
136negative regulation of cholesterol transport (GO:0032375)3.19208484
137positive regulation of natural killer cell differentiation (GO:0032825)3.18815237
138T cell mediated immunity (GO:0002456)3.18755746
139T cell costimulation (GO:0031295)3.17115203
140regulation of regulatory T cell differentiation (GO:0045589)3.16631682
141chronic inflammatory response (GO:0002544)3.16410286
142sulfur amino acid catabolic process (GO:0000098)3.15425226
143tryptophan metabolic process (GO:0006568)3.15395466
144positive regulation of T cell apoptotic process (GO:0070234)3.14976972
145regulation of triglyceride catabolic process (GO:0010896)3.14772560
146negative regulation of viral process (GO:0048525)3.14512328
147protoporphyrinogen IX metabolic process (GO:0046501)3.13897946
148antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13108093
149antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13108093
150leukotriene metabolic process (GO:0006691)3.11675443
151regulation of cell killing (GO:0031341)3.10985898
152antibacterial humoral response (GO:0019731)3.09155594
153regulation of B cell receptor signaling pathway (GO:0050855)3.08984429
154regulation of lymphocyte migration (GO:2000401)3.08929154
155regulation of dendritic cell antigen processing and presentation (GO:0002604)3.06851156
156acute-phase response (GO:0006953)3.06764006
157regulation of mononuclear cell migration (GO:0071675)3.05748687
158antigen processing and presentation of endogenous antigen (GO:0019883)3.04192696
159neutrophil activation (GO:0042119)3.04043551
160fat-soluble vitamin biosynthetic process (GO:0042362)3.03940369
161phosphatidylethanolamine metabolic process (GO:0046337)3.03702402
162immunoglobulin mediated immune response (GO:0016064)3.03304086
163monocyte chemotaxis (GO:0002548)3.03043241
164regulation of T cell migration (GO:2000404)3.02980635
165positive regulation of cholesterol efflux (GO:0010875)3.00968428
166positive regulation of interleukin-1 beta secretion (GO:0050718)2.99271639
167DNA demethylation (GO:0080111)2.97476048
168positive regulation of sterol transport (GO:0032373)2.95425064
169positive regulation of cholesterol transport (GO:0032376)2.95425064
170low-density lipoprotein particle clearance (GO:0034383)2.94362659
171bile acid metabolic process (GO:0008206)2.92789011
172cysteine metabolic process (GO:0006534)2.92688470
173detection of external biotic stimulus (GO:0098581)2.89345251
174regulation of interleukin-8 secretion (GO:2000482)2.87059536
175regulation of Rap GTPase activity (GO:0032317)2.85118817
176regulation of viral genome replication (GO:0045069)2.83858532
177antimicrobial humoral response (GO:0019730)2.83392773
178positive regulation of interleukin-1 secretion (GO:0050716)2.82718935
179regulation of interleukin-1 beta secretion (GO:0050706)2.81578673
180positive regulation of humoral immune response (GO:0002922)2.80631137
181triglyceride homeostasis (GO:0070328)2.80278810
182acylglycerol homeostasis (GO:0055090)2.80278810
183mucosal immune response (GO:0002385)2.79912832
184lymphocyte migration (GO:0072676)2.79583374
185protein-lipid complex subunit organization (GO:0071825)2.79046573
186plasma lipoprotein particle organization (GO:0071827)2.78618766
187regulation of tolerance induction (GO:0002643)2.77359270
188positive regulation of interleukin-17 production (GO:0032740)2.76769244
189modulation by host of viral transcription (GO:0043921)2.75474227
190modulation by host of symbiont transcription (GO:0052472)2.75474227
191modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.74420788
192chemokine-mediated signaling pathway (GO:0070098)2.72684773
193positive regulation of T cell mediated cytotoxicity (GO:0001916)2.71922152
194leukocyte aggregation (GO:0070486)2.71286936
195positive regulation of interleukin-4 production (GO:0032753)2.71127713
196cytidine deamination (GO:0009972)10.7033076
197cytidine metabolic process (GO:0046087)10.7033076
198cytidine catabolic process (GO:0006216)10.7033076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.34309522
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.32842828
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.04740754
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.52701610
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.29671244
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.15075146
7IRF8_21731497_ChIP-ChIP_J774_Mouse4.14074036
8LXR_22158963_ChIP-Seq_LIVER_Mouse4.07868736
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.98127681
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.31931235
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.99015683
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.99012447
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.94142629
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.92031860
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.90868139
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72746898
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.67468771
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65523189
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.61405178
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61069083
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.59230341
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.58951502
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.58040572
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22655322
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20654347
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19672120
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19618199
28MYB_26560356_Chip-Seq_TH1_Human2.14588299
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.13884595
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90301730
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84831816
32GATA3_27048872_Chip-Seq_THYMUS_Human1.79382128
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68940608
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66465322
35GATA3_26560356_Chip-Seq_TH2_Human1.66448812
36VDR_22108803_ChIP-Seq_LS180_Human1.66358916
37MAF_26560356_Chip-Seq_TH2_Human1.56920833
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55476951
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54378346
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54320324
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48374258
42SCL_19346495_ChIP-Seq_HPC-7_Human1.47827541
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46865153
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.46010957
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42714806
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38309108
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36499532
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36489953
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.32816356
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.32576867
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32247815
52SPI1_23127762_ChIP-Seq_K562_Human1.30207796
53EZH2_22144423_ChIP-Seq_EOC_Human1.27648091
54LXR_22292898_ChIP-Seq_THP-1_Human1.27145059
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25541184
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25100282
57GATA2_19941826_ChIP-Seq_K562_Human1.20939876
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20538946
59TCF7_22412390_ChIP-Seq_EML_Mouse1.20379948
60CLOCK_20551151_ChIP-Seq_293T_Human1.18990695
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18120775
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.16769388
63* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16438907
64GATA1_19941826_ChIP-Seq_K562_Human1.15890966
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14296469
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12956552
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12170495
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11902970
69VDR_24787735_ChIP-Seq_THP-1_Human1.11721758
70VDR_24763502_ChIP-Seq_THP-1_Human1.11040138
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11017299
72VDR_21846776_ChIP-Seq_THP-1_Human1.10565282
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09652932
74* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09212555
75RUNX_20019798_ChIP-Seq_JUKART_Human1.07362193
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07305506
77BCL6_27268052_Chip-Seq_Bcells_Human1.06830676
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.05169602
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.03604453
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03405399
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02974290
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02898169
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01775260
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01704718
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99664199
86SPI1_20517297_ChIP-Seq_HL60_Human0.99309042
87NANOG_20526341_ChIP-Seq_ESCs_Human0.98531906
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98015644
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97228579
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96617519
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95843942
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95182035
93MAF_26560356_Chip-Seq_TH1_Human0.95058576
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.93892926
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93535396
96SPI1_23547873_ChIP-Seq_NB4_Human0.93245428
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93213173
98EGR1_19374776_ChIP-ChIP_THP-1_Human0.92742383
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91622297
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91534104
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90622935
102TP53_22573176_ChIP-Seq_HFKS_Human0.90023608
103HTT_18923047_ChIP-ChIP_STHdh_Human0.90009435
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89898226
105PU_27001747_Chip-Seq_BMDM_Mouse0.89411925
106GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88835556
107KDM2B_26808549_Chip-Seq_DND41_Human0.88543810
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87466619
109FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87376115
110P300_27268052_Chip-Seq_Bcells_Human0.87166218
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86991825
112PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86319048
113MYC_22102868_ChIP-Seq_BL_Human0.85749365
114GATA3_26560356_Chip-Seq_TH1_Human0.85609246
115TAF2_19829295_ChIP-Seq_ESCs_Human0.85592712
116RUNX1_22412390_ChIP-Seq_EML_Mouse0.84985298
117FOXP3_21729870_ChIP-Seq_TREG_Human0.84270091
118ERG_20517297_ChIP-Seq_VCAP_Human0.84231148
119GABP_17652178_ChIP-ChIP_JURKAT_Human0.83378415
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83229702
121EGR1_19032775_ChIP-ChIP_M12_Human0.83092866
122VDR_23849224_ChIP-Seq_CD4+_Human0.81686835
123CTCF_20526341_ChIP-Seq_ESCs_Human0.81185684
124KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.80606783
125CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80296084
126RACK7_27058665_Chip-Seq_MCF-7_Human0.79262808
127CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79177653
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78661726
129HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78657200
130HNF4A_19822575_ChIP-Seq_HepG2_Human0.78231550
131MYB_26560356_Chip-Seq_TH2_Human0.78028935
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77814160
133GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77058517
134* FOXH1_21741376_ChIP-Seq_EPCs_Human0.74618024
135NANOG_19829295_ChIP-Seq_ESCs_Human0.74022348
136SOX2_19829295_ChIP-Seq_ESCs_Human0.74022348
137GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73848144
138UTX_26944678_Chip-Seq_JUKART_Human0.72345454
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71896134
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70574924
141SMRT_27268052_Chip-Seq_Bcells_Human0.70305203
142KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69990699
143FLI1_21867929_ChIP-Seq_CD8_Mouse0.69853702
144ETV2_25802403_ChIP-Seq_MESCs_Mouse0.69849332
145RXRA_24833708_ChIP-Seq_LIVER_Mouse0.69730129
146SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69501357
147KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69153539
148FOXA1_21572438_ChIP-Seq_LNCaP_Human0.69059039
149STAT1_20625510_ChIP-Seq_HELA_Human0.68492658
150BCOR_27268052_Chip-Seq_Bcells_Human0.68345064
151EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.68228893
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68124878
153OCT4_20526341_ChIP-Seq_ESCs_Human0.67911626
154CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.66366794
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66176712
156ELF1_20517297_ChIP-Seq_JURKAT_Human0.66050539
157* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.65557727
158* FOXA1_25329375_ChIP-Seq_VCAP_Human0.65557727
159SA1_27219007_Chip-Seq_Bcells_Human0.65189791
160GATA6_21074721_ChIP-Seq_CACO-2_Human0.65086550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.01564552
2MP0002139_abnormal_hepatobiliary_system4.66384489
3MP0005360_urolithiasis4.64080880
4MP0009840_abnormal_foam_cell4.55189818
5MP0005365_abnormal_bile_salt3.54477539
6MP0005085_abnormal_gallbladder_physiolo3.38216186
7MP0003436_decreased_susceptibility_to3.08751764
8MP0003045_fibrosis2.92167990
9MP0003763_abnormal_thymus_physiology2.87493421
10MP0004147_increased_porphyrin_level2.87189665
11MP0008875_abnormal_xenobiotic_pharmacok2.84755618
12MP0005058_abnormal_lysosome_morphology2.84327995
13MP0003191_abnormal_cellular_cholesterol2.75740426
14MP0003724_increased_susceptibility_to2.71954372
15MP0005387_immune_system_phenotype2.59136742
16MP0001790_abnormal_immune_system2.59136742
17MP0010329_abnormal_lipoprotein_level2.53337948
18MP0000685_abnormal_immune_system2.39743528
19MP0003705_abnormal_hypodermis_morpholog2.29993351
20MP0003252_abnormal_bile_duct2.19056748
21MP0005025_abnormal_response_to2.15146943
22MP0003303_peritoneal_inflammation2.14332863
23MP0003075_altered_response_to2.08529998
24MP0002138_abnormal_hepatobiliary_system2.06905434
25* MP0002419_abnormal_innate_immunity2.02116630
26MP0001835_abnormal_antigen_presentation2.00913728
27MP0001533_abnormal_skeleton_physiology1.92477563
28MP0000569_abnormal_digit_pigmentation1.88190617
29MP0005464_abnormal_platelet_physiology1.86376934
30MP0003448_altered_tumor_morphology1.82469953
31MP0000604_amyloidosis1.81655334
32MP0000609_abnormal_liver_physiology1.81216303
33MP0002876_abnormal_thyroid_physiology1.79834724
34MP0003656_abnormal_erythrocyte_physiolo1.79365353
35MP0010155_abnormal_intestine_physiology1.78545205
36MP0004947_skin_inflammation1.76524460
37MP0010368_abnormal_lymphatic_system1.76306552
38MP0005451_abnormal_body_composition1.74179712
39MP0005332_abnormal_amino_acid1.74129971
40MP0000703_abnormal_thymus_morphology1.69541595
41MP0004510_myositis1.68840251
42MP0005083_abnormal_biliary_tract1.67317864
43MP0001873_stomach_inflammation1.65630764
44MP0005670_abnormal_white_adipose1.63900006
45MP0008995_early_reproductive_senescence1.63346836
46* MP0001800_abnormal_humoral_immune1.61487019
47MP0003866_abnormal_defecation1.58569058
48* MP0005000_abnormal_immune_tolerance1.57826424
49MP0009763_increased_sensitivity_to1.57291905
50MP0002148_abnormal_hypersensitivity_rea1.54241384
51MP0002118_abnormal_lipid_homeostasis1.53240022
52MP0005646_abnormal_pituitary_gland1.51937884
53* MP0002452_abnormal_antigen_presenting1.46064611
54MP0003195_calcinosis1.45649139
55MP0003806_abnormal_nucleotide_metabolis1.44908888
56MP0001348_abnormal_lacrimal_gland1.42125902
57MP0008438_abnormal_cutaneous_collagen1.41639924
58MP0008469_abnormal_protein_level1.41366836
59MP0005075_abnormal_melanosome_morpholog1.40694203
60MP0003183_abnormal_peptide_metabolism1.39364230
61MP0004145_abnormal_muscle_electrophysio1.35245209
62MP0001845_abnormal_inflammatory_respons1.34332280
63MP0004019_abnormal_vitamin_homeostasis1.33655780
64MP0003646_muscle_fatigue1.33443295
65MP0009785_altered_susceptibility_to1.31703520
66MP0001851_eye_inflammation1.30298095
67MP0001666_abnormal_nutrient_absorption1.28926216
68MP0002163_abnormal_gland_morphology1.28494522
69MP0005310_abnormal_salivary_gland1.23912528
70MP0005319_abnormal_enzyme/_coenzyme1.23607919
71MP0005410_abnormal_fertilization1.22170305
72MP0002166_altered_tumor_susceptibility1.21939916
73MP0005584_abnormal_enzyme/coenzyme_acti1.20827007
74MP0004742_abnormal_vestibular_system1.18679128
75MP0003690_abnormal_glial_cell1.18220637
76* MP0002723_abnormal_immune_serum1.17063268
77MP0000249_abnormal_blood_vessel1.16358723
78MP0003300_gastrointestinal_ulcer1.16172464
79* MP0002420_abnormal_adaptive_immunity1.15966306
80* MP0001819_abnormal_immune_cell1.15274365
81MP0000598_abnormal_liver_morphology1.11518054
82MP0002405_respiratory_system_inflammati1.11110889
83MP0000767_abnormal_smooth_muscle1.10988948
84MP0000689_abnormal_spleen_morphology1.09590511
85MP0002254_reproductive_system_inflammat1.07395743
86MP0002095_abnormal_skin_pigmentation1.07064017
87MP0005023_abnormal_wound_healing1.06775454
88MP0004381_abnormal_hair_follicle1.03631585
89MP0005166_decreased_susceptibility_to1.03417404
90MP0009765_abnormal_xenobiotic_induced1.03113538
91MP0005636_abnormal_mineral_homeostasis1.00573875
92MP0001915_intracranial_hemorrhage1.00266763
93MP0009643_abnormal_urine_homeostasis0.99118963
94MP0002168_other_aberrant_phenotype0.95946434
95MP0001919_abnormal_reproductive_system0.95500964
96MP0002132_abnormal_respiratory_system0.95373368
97MP0006082_CNS_inflammation0.94924886
98* MP0000716_abnormal_immune_system0.92575992
99MP0005395_other_phenotype0.92309154
100MP0003172_abnormal_lysosome_physiology0.91823261
101MP0009764_decreased_sensitivity_to0.91411339
102MP0000858_altered_metastatic_potential0.90662999
103MP0002136_abnormal_kidney_physiology0.89743348
104MP0000343_altered_response_to0.88216624
105MP0001853_heart_inflammation0.88147164
106MP0001661_extended_life_span0.88081755
107MP0001986_abnormal_taste_sensitivity0.87941597
108MP0002971_abnormal_brown_adipose0.86476466
109MP0003011_delayed_dark_adaptation0.85769040
110MP0001764_abnormal_homeostasis0.84856611
111MP0002019_abnormal_tumor_incidence0.84207846
112MP0005390_skeleton_phenotype0.84160090
113MP0002277_abnormal_respiratory_mucosa0.84031666
114MP0005174_abnormal_tail_pigmentation0.82812674
115MP0003329_amyloid_beta_deposits0.82411461
116MP0004185_abnormal_adipocyte_glucose0.81802483
117MP0009642_abnormal_blood_homeostasis0.81424516
118MP0002933_joint_inflammation0.81417394
119MP0003786_premature_aging0.80664056
120MP0003566_abnormal_cell_adhesion0.80220785
121MP0005408_hypopigmentation0.78711630
122MP0008873_increased_physiological_sensi0.77178393
123MP0002722_abnormal_immune_system0.76106073
124MP0000465_gastrointestinal_hemorrhage0.75500111
125MP0004130_abnormal_muscle_cell0.74228540
126MP0002006_tumorigenesis0.73219290
127MP0001849_ear_inflammation0.72997971
128MP0008872_abnormal_physiological_respon0.72993072
129* MP0002429_abnormal_blood_cell0.72455989
130MP0002398_abnormal_bone_marrow0.72047101
131MP0005645_abnormal_hypothalamus_physiol0.71765426
132MP0005535_abnormal_body_temperature0.71704467
133MP0002736_abnormal_nociception_after0.71521148
134MP0003868_abnormal_feces_composition0.70911130
135MP0002998_abnormal_bone_remodeling0.70252044
136MP0000681_abnormal_thyroid_gland0.68253156
137MP0001243_abnormal_dermal_layer0.67966096
138MP0003638_abnormal_response/metabolism_0.67892569
139MP0003718_maternal_effect0.66328826
140MP0001968_abnormal_touch/_nociception0.65917723
141MP0008877_abnormal_DNA_methylation0.65618401
142MP0005379_endocrine/exocrine_gland_phen0.64303650
143* MP0009333_abnormal_splenocyte_physiolog0.63907683
144MP0005248_abnormal_Harderian_gland0.63657845
145MP0008789_abnormal_olfactory_epithelium0.62594694
146MP0005647_abnormal_sex_gland0.62069531
147MP0005666_abnormal_adipose_tissue0.61819356
148MP0000639_abnormal_adrenal_gland0.60722190
149MP0005389_reproductive_system_phenotype0.60553547
150MP0001765_abnormal_ion_homeostasis0.57997595

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)8.12801327
2Glomerulonephritis (HP:0000099)7.58166925
3Abnormality of complement system (HP:0005339)7.54991513
4T lymphocytopenia (HP:0005403)7.18615879
5Abnormality of T cell number (HP:0011839)7.02119108
6Deep venous thrombosis (HP:0002625)6.50526860
7Chronic diarrhea (HP:0002028)5.76975787
8Recurrent gram-negative bacterial infections (HP:0005420)5.31542230
9Prolonged partial thromboplastin time (HP:0003645)5.24638106
10Aplastic anemia (HP:0001915)4.69234527
11Nephritis (HP:0000123)4.55702548
12Abnormality of T cells (HP:0002843)4.53216723
13Abnormality of the common coagulation pathway (HP:0010990)4.29395288
14Autoimmune hemolytic anemia (HP:0001890)4.24057720
15Joint hemorrhage (HP:0005261)4.07785059
16Vacuolated lymphocytes (HP:0001922)4.03552418
17Dysostosis multiplex (HP:0000943)3.97721206
18Xanthomatosis (HP:0000991)3.93255184
19Increased IgM level (HP:0003496)3.92121468
20IgG deficiency (HP:0004315)3.79312588
21Recurrent abscess formation (HP:0002722)3.63295718
22Severe combined immunodeficiency (HP:0004430)3.57103076
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.56106271
24Joint swelling (HP:0001386)3.42187370
25Abnormality of the heme biosynthetic pathway (HP:0010472)3.41011395
26Menorrhagia (HP:0000132)3.39304395
27Intrahepatic cholestasis (HP:0001406)3.38304435
28Recurrent viral infections (HP:0004429)3.36674401
29Mucopolysacchariduria (HP:0008155)3.35299554
30Urinary glycosaminoglycan excretion (HP:0003541)3.35299554
31Shallow orbits (HP:0000586)3.34604004
32Abnormality of monocarboxylic acid metabolism (HP:0010996)3.33169527
33Pustule (HP:0200039)3.31279582
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.27754212
35Eczematoid dermatitis (HP:0000976)3.27708798
36Peritonitis (HP:0002586)3.26639623
37Abnormality of eosinophils (HP:0001879)3.26287651
38Autoimmune thrombocytopenia (HP:0001973)3.22959047
39Abnormality of polysaccharide metabolism (HP:0011012)3.22631009
40Abnormality of glycosaminoglycan metabolism (HP:0004371)3.22631009
41Abnormality of mucopolysaccharide metabolism (HP:0011020)3.22631009
42Spondylolisthesis (HP:0003302)3.21499943
43Recurrent bacterial skin infections (HP:0005406)3.20539696
44Nasal polyposis (HP:0100582)3.17956031
45Granulocytopenia (HP:0001913)3.17551476
46Asymmetric septal hypertrophy (HP:0001670)3.15541566
47Elevated erythrocyte sedimentation rate (HP:0003565)3.11783712
48Arthropathy (HP:0003040)3.10869721
49Loss of speech (HP:0002371)3.04338032
50Combined immunodeficiency (HP:0005387)3.01476390
51Carpal bone hypoplasia (HP:0001498)2.97238398
52Recurrent fungal infections (HP:0002841)2.94798817
53Abnormality of the nasal mucosa (HP:0000433)2.88100144
54Hypobetalipoproteinemia (HP:0003563)2.82912887
55Esophageal varix (HP:0002040)2.79891165
56Cervical subluxation (HP:0003308)2.78967421
57Gastrointestinal infarctions (HP:0005244)2.77256844
58IgM deficiency (HP:0002850)2.77225239
59Thyroiditis (HP:0100646)2.76814132
60Recurrent bronchitis (HP:0002837)2.76437176
61Myositis (HP:0100614)2.75721399
62Recurrent cutaneous fungal infections (HP:0011370)2.74472080
63Chronic mucocutaneous candidiasis (HP:0002728)2.74472080
64Hypochromic microcytic anemia (HP:0004840)2.69708334
65Myocardial infarction (HP:0001658)2.69540329
66Hypochromic anemia (HP:0001931)2.69337972
67Hyperlipoproteinemia (HP:0010980)2.67865229
68Meningitis (HP:0001287)2.67643863
69Wrist flexion contracture (HP:0001239)2.64526694
70Leukocytosis (HP:0001974)2.63534448
71IgA deficiency (HP:0002720)2.63165281
72Abnormality of the prostate (HP:0008775)2.58681416
73Abnormality of B cell number (HP:0010975)2.58620045
74Anorexia (HP:0002039)2.57236244
75Nausea (HP:0002018)2.55381441
76B lymphocytopenia (HP:0010976)2.53175325
77Hypoalphalipoproteinemia (HP:0003233)2.51299534
78Hypergammaglobulinemia (HP:0010702)2.49263330
79Abnormality of cells of the lymphoid lineage (HP:0012140)2.49222381
80Generalized aminoaciduria (HP:0002909)2.48285264
81J-shaped sella turcica (HP:0002680)2.46463586
82Hypolipoproteinemia (HP:0010981)2.45848891
83Constricted visual fields (HP:0001133)2.45173325
84Amyloidosis (HP:0011034)2.44766323
85Hypoproteinemia (HP:0003075)2.43584742
86Oligomenorrhea (HP:0000876)2.41386223
87Mediastinal lymphadenopathy (HP:0100721)2.39980724
88Microcytic anemia (HP:0001935)2.38290899
89Mitral stenosis (HP:0001718)2.38169657
90Short nail (HP:0001799)2.36558896
91Eosinophilia (HP:0001880)2.36326065
92Lymphopenia (HP:0001888)2.35941579
93Abnormality of T cell physiology (HP:0011840)2.34953404
94Abnormality of the lumbar spine (HP:0100712)2.34939617
95Cholelithiasis (HP:0001081)2.33065694
96Prolonged bleeding time (HP:0003010)2.32788094
97Joint stiffness (HP:0001387)2.32277078
98Periodontitis (HP:0000704)2.31365663
99Thoracic kyphosis (HP:0002942)2.28724369
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.27106358
101Epidermoid cyst (HP:0200040)2.27009449
102Gingival bleeding (HP:0000225)2.26272003
103Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25764122
104Hyperammonemia (HP:0001987)2.25688054
105Vasculitis (HP:0002633)2.25282942
106Agammaglobulinemia (HP:0004432)2.23689613
107Hyponatremia (HP:0002902)2.22123562
108Polygenic inheritance (HP:0010982)2.21512330
109Encephalitis (HP:0002383)2.21511799
110Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.20336471
111Hypercholesterolemia (HP:0003124)2.20310872
112Epistaxis (HP:0000421)2.19494622
113Spontaneous hematomas (HP:0007420)2.19282577
114Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16395461
115Abnormality of macrophages (HP:0004311)2.15499393
116Recurrent skin infections (HP:0001581)2.14137521
117Abnormality of sulfur amino acid metabolism (HP:0004339)2.11184145
118Severe visual impairment (HP:0001141)2.09670512
119Gingivitis (HP:0000230)2.09010372
120Pulmonary infiltrates (HP:0002113)2.08909412
121Congenital sensorineural hearing impairment (HP:0008527)2.08524556
122Abnormality of alanine metabolism (HP:0010916)2.08141446
123Hyperalaninemia (HP:0003348)2.08141446
124Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08141446
125Cerebral aneurysm (HP:0004944)2.07716740
126Abnormal gallbladder physiology (HP:0012438)2.07526635
127Cholecystitis (HP:0001082)2.07526635
128Bronchomalacia (HP:0002780)2.06907344
129Attenuation of retinal blood vessels (HP:0007843)2.05411756
130Deformed sella turcica (HP:0002681)2.04806089
131Abnormal gallbladder morphology (HP:0012437)2.04270740
132Stomatitis (HP:0010280)2.03379715
133Lymphoma (HP:0002665)2.01924214
134Obstructive lung disease (HP:0006536)2.01870756
135Chronic obstructive pulmonary disease (HP:0006510)2.01870756
136Increased serum ferritin (HP:0003281)2.01738851
137Arterial thrombosis (HP:0004420)2.01059805
138Systemic lupus erythematosus (HP:0002725)10.6483908
139Fatigue (HP:0012378)1.99968643
140Toxemia of pregnancy (HP:0100603)1.99619592
141Hemoptysis (HP:0002105)1.98784253
142Poikilocytosis (HP:0004447)1.96745882
143Enlarged penis (HP:0000040)1.95363659
144Inflammation of the large intestine (HP:0002037)1.92759942
145Pulmonary embolism (HP:0002204)1.91552370
146Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90243370
147Neutropenia (HP:0001875)1.89417404
148Abnormality of pyrimidine metabolism (HP:0004353)1.88591141
149Turricephaly (HP:0000262)1.88146819
150Increased intramyocellular lipid droplets (HP:0012240)1.88100041
151Hand muscle atrophy (HP:0009130)1.87297041
152Acute hepatic failure (HP:0006554)1.86877025
153Pancytopenia (HP:0001876)1.86860739
154Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86488728
155Ketosis (HP:0001946)1.85965498
156Abnormality of homocysteine metabolism (HP:0010919)1.85724441
157Homocystinuria (HP:0002156)1.85724441
158Abnormality of the intrinsic pathway (HP:0010989)1.84540100
159Colitis (HP:0002583)1.84045474
160Neurofibrillary tangles (HP:0002185)1.83575267
161Multifactorial inheritance (HP:0001426)1.82595397
162Arterial tortuosity (HP:0005116)1.82443776
163Thrombophlebitis (HP:0004418)1.81060290
164Purpura (HP:0000979)1.80632549
165Urticaria (HP:0001025)1.80056780
166Optic neuritis (HP:0100653)1.80032799
167Retrobulbar optic neuritis (HP:0100654)1.80032799
168Abnormality of methionine metabolism (HP:0010901)1.77962459
169Abnormality of nucleobase metabolism (HP:0010932)1.77080977
170Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76617705
171Coarse hair (HP:0002208)1.74884816
172Fat malabsorption (HP:0002630)1.73647670
173Hypoglycemic coma (HP:0001325)1.73583852
174Broad metatarsal (HP:0001783)1.72036576
175Beaking of vertebral bodies (HP:0004568)1.72003269
176Hemorrhage of the eye (HP:0011885)1.71949520
177Abnormality of purine metabolism (HP:0004352)1.71325895
178Ovoid vertebral bodies (HP:0003300)1.70189032
179Pathologic fracture (HP:0002756)1.67642495
180Renal tubular acidosis (HP:0001947)1.67641164
181Flat acetabular roof (HP:0003180)1.66309928
182Abnormality of iron homeostasis (HP:0011031)1.64744481
183Abnormality of fatty-acid metabolism (HP:0004359)1.64174168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.49197868
2TXK4.81837631
3TESK24.54502314
4PIK3CA3.85623582
5ERN13.71551216
6TAOK33.59684105
7ITK3.48381144
8BLK3.30990193
9CAMK1D3.21587175
10TYK22.86824878
11TRIB32.66962616
12MAP4K12.54921823
13VRK22.53495295
14DAPK22.49085757
15MET2.34944523
16CAMK1G2.28536847
17RIPK12.25054448
18TNK22.21558810
19EIF2AK32.17188667
20PKN22.08921813
21EPHB12.07544122
22MAP3K131.93685815
23TBK11.90955699
24FGFR41.85428225
25PRKCQ1.85050385
26BMX1.82969164
27TEC1.57851036
28NUAK11.53236865
29MAP3K61.49064217
30TLK11.49000359
31JAK11.47606526
32STK101.47225335
33TESK11.46657120
34TGFBR21.45514458
35ZAK1.44512789
36GRK61.43786648
37VRK11.42537461
38IKBKE1.30278685
39IRAK41.28601767
40CSK1.27781249
41KIT1.26646670
42PTK61.26291635
43MAP3K141.24776611
44FES1.24348531
45FGR1.19427786
46ZAP701.17531421
47SIK11.17170375
48BCKDK1.16081666
49MAP3K121.09159749
50HCK1.05551878
51EPHA31.05133881
52ACVR1B0.99617796
53JAK30.99446756
54MAP3K110.99205441
55ERBB40.95624065
56CSF1R0.94283355
57MAP2K30.92478977
58JAK20.91637543
59PRKCH0.90818669
60CLK10.86971622
61TTN0.86117564
62EEF2K0.85875555
63IKBKB0.83017429
64PRKAA20.78654875
65MAP3K100.76987730
66EIF2AK10.74304813
67SYK0.73944819
68LRRK20.73846324
69CAMKK10.73381358
70EPHB20.72223143
71RIPK40.71388428
72STK380.70436423
73NTRK20.69988350
74MAP2K40.69853985
75IGF1R0.68997679
76LCK0.68453450
77BTK0.67663162
78MST40.65096696
79PIM10.64672167
80BUB10.64607994
81MAP3K70.63883515
82PIK3CG0.63741717
83MAPK120.63706341
84SIK20.62707022
85MARK30.61696750
86LATS10.60424281
87MAPK110.58453141
88EGFR0.57256314
89CHUK0.56843834
90INSRR0.56574645
91DAPK10.56050869
92NEK90.54516184
93GRK10.54135775
94FLT30.54113175
95ARAF0.54076851
96MYLK0.53950007
97GRK70.53872492
98ABL20.53639020
99MAP3K10.53082383
100FGFR30.51771651
101KSR20.51540163
102DAPK30.50443642
103PKN10.49524441
104PDPK10.49131486
105INSR0.48895583
106ADRBK20.48290680
107ADRBK10.46918795
108RPS6KA40.46861536
109AURKA0.46512714
110STK30.45351433
111RET0.45013186
112CAMKK20.42858161
113MATK0.42776222
114CDK40.42537754
115MUSK0.42420574
116MOS0.42094896
117LYN0.41833582
118TIE10.41634417
119MAP3K90.41501958
120RPS6KA20.40039920
121BMPR20.38837875
122MAPKAPK20.38699697
123ROCK10.38684922
124PRKCA0.37958811
125PRKCD0.37794783
126KDR0.35455186
127TAOK20.35105345
128BCR0.34903333
129PLK40.32739143
130RPS6KA50.32292312
131CAMK2A0.32173675
132PDK10.31972513
133PAK10.31963409
134TAOK10.30996498
135FYN0.30382292
136STK240.28308017
137SGK30.27720225
138FGFR10.27669564
139CSNK1A10.26886532
140PTK20.26538397
141GSK3A0.25364638
142MAP3K30.24918751
143CDK90.24859067
144SCYL20.24495058
145MELK0.24313892
146MAPK40.24283588
147MAPK30.24086110
148SRC0.23949668
149PRKACA0.23426569
150PRKCB0.22872335
151MAP2K10.21148895
152LMTK20.20965023

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051506.83990833
2Primary immunodeficiency_Homo sapiens_hsa053405.19726837
3Complement and coagulation cascades_Homo sapiens_hsa046104.89933783
4Graft-versus-host disease_Homo sapiens_hsa053324.63077833
5Allograft rejection_Homo sapiens_hsa053304.10200500
6Autoimmune thyroid disease_Homo sapiens_hsa053203.98899792
7Other glycan degradation_Homo sapiens_hsa005113.54385104
8Antigen processing and presentation_Homo sapiens_hsa046123.46760731
9Primary bile acid biosynthesis_Homo sapiens_hsa001203.25463201
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.23766467
11Nitrogen metabolism_Homo sapiens_hsa009103.18454455
12Type I diabetes mellitus_Homo sapiens_hsa049403.07475640
13Caffeine metabolism_Homo sapiens_hsa002322.97335679
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.62330314
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49910508
16Rheumatoid arthritis_Homo sapiens_hsa053232.42586711
17Glycosaminoglycan degradation_Homo sapiens_hsa005312.41038280
18Proteasome_Homo sapiens_hsa030502.39581656
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.28717325
20Arginine biosynthesis_Homo sapiens_hsa002202.21434857
21T cell receptor signaling pathway_Homo sapiens_hsa046602.18122124
22Asthma_Homo sapiens_hsa053102.17800144
23Pertussis_Homo sapiens_hsa051331.94401965
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90018162
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83438499
26Tryptophan metabolism_Homo sapiens_hsa003801.71792052
27Fatty acid degradation_Homo sapiens_hsa000711.65956688
28Linoleic acid metabolism_Homo sapiens_hsa005911.60675914
29Histidine metabolism_Homo sapiens_hsa003401.59093480
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56890104
31Prion diseases_Homo sapiens_hsa050201.48135228
32PPAR signaling pathway_Homo sapiens_hsa033201.45873941
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42302293
34Oxidative phosphorylation_Homo sapiens_hsa001901.35176543
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34250225
36Arachidonic acid metabolism_Homo sapiens_hsa005901.33302428
37Leishmaniasis_Homo sapiens_hsa051401.31624054
38Salmonella infection_Homo sapiens_hsa051321.30717652
39Peroxisome_Homo sapiens_hsa041461.28809424
40Malaria_Homo sapiens_hsa051441.26402465
41ABC transporters_Homo sapiens_hsa020101.25861102
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23977760
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22026205
44beta-Alanine metabolism_Homo sapiens_hsa004101.18963912
45Fatty acid metabolism_Homo sapiens_hsa012121.16122727
46Viral myocarditis_Homo sapiens_hsa054161.15748584
47Collecting duct acid secretion_Homo sapiens_hsa049661.12472140
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.11029248
49Parkinsons disease_Homo sapiens_hsa050121.09458682
50African trypanosomiasis_Homo sapiens_hsa051431.06985969
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06904513
52Lysosome_Homo sapiens_hsa041421.06026680
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00939700
54Chemical carcinogenesis_Homo sapiens_hsa052040.98499927
55Propanoate metabolism_Homo sapiens_hsa006400.98210859
56Bile secretion_Homo sapiens_hsa049760.97646691
57Starch and sucrose metabolism_Homo sapiens_hsa005000.96625125
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92436034
59Herpes simplex infection_Homo sapiens_hsa051680.92372306
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91620317
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91085105
62Lysine degradation_Homo sapiens_hsa003100.89901116
63Butanoate metabolism_Homo sapiens_hsa006500.89658103
64Retinol metabolism_Homo sapiens_hsa008300.88920443
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.84804551
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83584894
67Phenylalanine metabolism_Homo sapiens_hsa003600.82787429
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77260029
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76485185
70One carbon pool by folate_Homo sapiens_hsa006700.73456232
71Folate biosynthesis_Homo sapiens_hsa007900.68901915
72Apoptosis_Homo sapiens_hsa042100.68822583
73Osteoclast differentiation_Homo sapiens_hsa043800.66329239
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65333645
75Protein export_Homo sapiens_hsa030600.65016401
76Influenza A_Homo sapiens_hsa051640.64242498
77Pyruvate metabolism_Homo sapiens_hsa006200.63233748
78Fat digestion and absorption_Homo sapiens_hsa049750.62608752
79Phototransduction_Homo sapiens_hsa047440.60578331
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59658681
81Chemokine signaling pathway_Homo sapiens_hsa040620.59381806
82Selenocompound metabolism_Homo sapiens_hsa004500.59003927
83Sulfur relay system_Homo sapiens_hsa041220.58538046
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58243580
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.58177396
86Tyrosine metabolism_Homo sapiens_hsa003500.57912616
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55758561
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55428281
89Amoebiasis_Homo sapiens_hsa051460.55411391
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53037811
91Legionellosis_Homo sapiens_hsa051340.52416649
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.51428086
93Shigellosis_Homo sapiens_hsa051310.50849973
94Tuberculosis_Homo sapiens_hsa051520.50680558
95Epstein-Barr virus infection_Homo sapiens_hsa051690.50359317
96Regulation of autophagy_Homo sapiens_hsa041400.49858896
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49829454
98Alzheimers disease_Homo sapiens_hsa050100.48434732
99RNA polymerase_Homo sapiens_hsa030200.47270272
100Fatty acid elongation_Homo sapiens_hsa000620.47249504
101TNF signaling pathway_Homo sapiens_hsa046680.46518988
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.45320921
103Hematopoietic cell lineage_Homo sapiens_hsa046400.44930646
104B cell receptor signaling pathway_Homo sapiens_hsa046620.44747476
105Vitamin digestion and absorption_Homo sapiens_hsa049770.44747141
106Biosynthesis of amino acids_Homo sapiens_hsa012300.43884066
107Toxoplasmosis_Homo sapiens_hsa051450.43634656
108Arginine and proline metabolism_Homo sapiens_hsa003300.42963290
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.42531773
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41651930
111HTLV-I infection_Homo sapiens_hsa051660.41250298
112Phagosome_Homo sapiens_hsa041450.40754901
113Pentose phosphate pathway_Homo sapiens_hsa000300.40408066
114Insulin resistance_Homo sapiens_hsa049310.39031163
115Ribosome_Homo sapiens_hsa030100.38894941
116Huntingtons disease_Homo sapiens_hsa050160.36892707
117Fatty acid biosynthesis_Homo sapiens_hsa000610.34390238
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33633017
119Carbon metabolism_Homo sapiens_hsa012000.33278176
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32841711
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31368092
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30888802
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30834449
124Olfactory transduction_Homo sapiens_hsa047400.30012977
125Platelet activation_Homo sapiens_hsa046110.28812177
126Glycerolipid metabolism_Homo sapiens_hsa005610.27290101
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.26734855
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26160530
129Ovarian steroidogenesis_Homo sapiens_hsa049130.25944073
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25655206
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.25154375
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25002294
133Hepatitis C_Homo sapiens_hsa051600.24619097
134Dorso-ventral axis formation_Homo sapiens_hsa043200.24211485
135Vitamin B6 metabolism_Homo sapiens_hsa007500.24198101
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.23485012
137Cardiac muscle contraction_Homo sapiens_hsa042600.23391844
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22092797
139Sulfur metabolism_Homo sapiens_hsa009200.21270703
140Pancreatic cancer_Homo sapiens_hsa052120.20817003
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19882072
142Acute myeloid leukemia_Homo sapiens_hsa052210.19290896
143Systemic lupus erythematosus_Homo sapiens_hsa053220.18983880
144Measles_Homo sapiens_hsa051620.17522790
145Galactose metabolism_Homo sapiens_hsa000520.17447927
146Steroid biosynthesis_Homo sapiens_hsa001000.17371572
147Alcoholism_Homo sapiens_hsa050340.16646162
148Basal transcription factors_Homo sapiens_hsa030220.13974125
149Viral carcinogenesis_Homo sapiens_hsa052030.12541890
150Morphine addiction_Homo sapiens_hsa050320.11342460
151Homologous recombination_Homo sapiens_hsa034400.10261067

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