TIGIT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.81304056
2interferon-gamma production (GO:0032609)5.26926805
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.23851944
4regulation of T cell tolerance induction (GO:0002664)5.23138166
5negative T cell selection (GO:0043383)5.13616985
6negative thymic T cell selection (GO:0045060)5.02607262
7cytidine deamination (GO:0009972)4.93906552
8cytidine metabolic process (GO:0046087)4.93906552
9cytidine catabolic process (GO:0006216)4.93906552
10positive T cell selection (GO:0043368)4.92779147
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.89181957
12DNA deamination (GO:0045006)4.89101689
13positive thymic T cell selection (GO:0045059)4.86968251
14NIK/NF-kappaB signaling (GO:0038061)4.68826133
15cellular response to interleukin-15 (GO:0071350)4.68483098
16antigen processing and presentation of endogenous antigen (GO:0019883)4.64846217
17regulation of gamma-delta T cell differentiation (GO:0045586)4.57049896
18tolerance induction (GO:0002507)4.56643096
19pyrimidine ribonucleoside catabolic process (GO:0046133)4.54400599
20regulation of lymphocyte chemotaxis (GO:1901623)4.46938199
21thymic T cell selection (GO:0045061)4.43875428
22leukocyte aggregation (GO:0070486)4.38881151
23T cell selection (GO:0045058)4.38698789
24positive regulation of T cell chemotaxis (GO:0010820)4.33526687
25regulation of T cell chemotaxis (GO:0010819)4.33526687
26T cell mediated immunity (GO:0002456)4.33204510
27regulation of isotype switching to IgG isotypes (GO:0048302)4.32409280
28regulation of B cell receptor signaling pathway (GO:0050855)4.27016927
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.19632497
30positive regulation of T cell mediated cytotoxicity (GO:0001916)4.19537812
31T cell migration (GO:0072678)4.12350471
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.07198537
33positive regulation of immune response to tumor cell (GO:0002839)4.01778229
34regulation of immune response to tumor cell (GO:0002837)4.01778229
35regulation of response to tumor cell (GO:0002834)4.01778229
36positive regulation of response to tumor cell (GO:0002836)4.01778229
37regulation of interleukin-2 biosynthetic process (GO:0045076)4.00933766
38daunorubicin metabolic process (GO:0044597)3.99808880
39polyketide metabolic process (GO:0030638)3.99808880
40doxorubicin metabolic process (GO:0044598)3.99808880
41regulation of B cell differentiation (GO:0045577)3.98012831
42regulation of T cell mediated cytotoxicity (GO:0001914)3.97418007
43positive regulation of tolerance induction (GO:0002645)3.92693821
44positive regulation of gamma-delta T cell activation (GO:0046645)3.92394270
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.90510424
46CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.87635167
47response to interleukin-15 (GO:0070672)3.86225339
48regulation of tolerance induction (GO:0002643)3.85278284
49activated T cell proliferation (GO:0050798)3.84506256
50positive regulation of humoral immune response (GO:0002922)3.83070052
51regulation of chronic inflammatory response (GO:0002676)3.82415031
52positive regulation of B cell differentiation (GO:0045579)3.79065309
53necroptotic process (GO:0070266)3.73700463
54lymphocyte costimulation (GO:0031294)3.65550757
55positive regulation of lymphocyte migration (GO:2000403)3.63540840
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.63413592
57T cell costimulation (GO:0031295)3.62308193
58positive regulation of uterine smooth muscle contraction (GO:0070474)3.62086959
59T cell homeostasis (GO:0043029)3.58582321
60T cell receptor signaling pathway (GO:0050852)3.58195354
61positive regulation of lymphocyte mediated immunity (GO:0002708)3.57449902
62positive regulation of alpha-beta T cell proliferation (GO:0046641)3.53432960
63regulation of regulatory T cell differentiation (GO:0045589)3.52343058
64T cell proliferation (GO:0042098)3.49595907
65positive regulation of granulocyte differentiation (GO:0030854)3.47815727
66positive regulation of defense response to virus by host (GO:0002230)3.44954304
67negative regulation of T cell mediated immunity (GO:0002710)3.42147240
68regulation of alpha-beta T cell proliferation (GO:0046640)3.40726391
69cellular response to type I interferon (GO:0071357)3.40472572
70type I interferon signaling pathway (GO:0060337)3.40472572
71G-protein coupled receptor internalization (GO:0002031)3.37946915
72response to type I interferon (GO:0034340)3.37274234
73myeloid dendritic cell differentiation (GO:0043011)3.36818199
74regulation of RIG-I signaling pathway (GO:0039535)3.34139210
75Arp2/3 complex-mediated actin nucleation (GO:0034314)3.30541148
76regulation of lymphocyte migration (GO:2000401)3.30512415
77defense response to protozoan (GO:0042832)3.27731655
78programmed necrotic cell death (GO:0097300)3.27149690
79regulation of necroptotic process (GO:0060544)3.26248312
80negative regulation of necroptotic process (GO:0060546)3.24477957
81antigen receptor-mediated signaling pathway (GO:0050851)3.22091509
82regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.20240642
83regulation of T cell receptor signaling pathway (GO:0050856)3.19661548
84antigen processing and presentation via MHC class Ib (GO:0002475)3.19239956
85cellular defense response (GO:0006968)3.18932665
86positive regulation of natural killer cell mediated immunity (GO:0002717)3.18489808
87positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.18489808
88positive regulation of B cell mediated immunity (GO:0002714)3.18349581
89positive regulation of immunoglobulin mediated immune response (GO:0002891)3.18349581
90G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.17872177
91negative regulation of nitric oxide biosynthetic process (GO:0045019)3.17286877
92positive regulation of leukocyte mediated immunity (GO:0002705)3.16001300
93T-helper cell differentiation (GO:0042093)3.15185579
94CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.15185579
95negative regulation of leukocyte mediated immunity (GO:0002704)3.14070789
96mesenchymal cell differentiation involved in kidney development (GO:0072161)3.13595438
97mesenchymal cell differentiation involved in renal system development (GO:2001012)3.13595438
98necrotic cell death (GO:0070265)3.11627883
99negative regulation of viral genome replication (GO:0045071)3.10928835
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09402621
101positive regulation of heat generation (GO:0031652)3.06499970
102modulation by virus of host process (GO:0019054)3.04881699
103negative regulation of B cell proliferation (GO:0030889)3.04718102
104regulation of isotype switching (GO:0045191)3.03981246
105negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00107437
106negative regulation of cell killing (GO:0031342)3.00107437
107regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.99709438
108regulation of natural killer cell mediated immunity (GO:0002715)2.99709438
109positive regulation of calcium-mediated signaling (GO:0050850)2.97118367
110mast cell activation (GO:0045576)2.96503154
111T cell differentiation involved in immune response (GO:0002292)2.94553494
112alpha-beta T cell differentiation involved in immune response (GO:0002293)2.94553494
113alpha-beta T cell activation involved in immune response (GO:0002287)2.94553494
114regulation of fever generation (GO:0031620)2.92245891
115tumor necrosis factor-mediated signaling pathway (GO:0033209)2.91865663
116alpha-beta T cell differentiation (GO:0046632)2.88046205
117positive regulation of interleukin-8 secretion (GO:2000484)2.81671299
118regulation of B cell proliferation (GO:0030888)2.79864078
119positive regulation of interleukin-1 beta secretion (GO:0050718)2.78386442
120negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.76564507
121positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.76313248
122dendritic cell chemotaxis (GO:0002407)2.70918176
123regulation of uterine smooth muscle contraction (GO:0070472)2.68451852
124CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.68040413
125B cell homeostasis (GO:0001782)2.67662190
126positive regulation of B cell proliferation (GO:0030890)2.66667576
127alpha-beta T cell activation (GO:0046631)2.65757383
128positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.65084613
129chemokine-mediated signaling pathway (GO:0070098)2.61823652
130regulation of immunoglobulin mediated immune response (GO:0002889)2.61379811
131positive regulation of interferon-gamma production (GO:0032729)2.59860489
132dendritic cell migration (GO:0036336)2.59495286
133histone H3-K4 trimethylation (GO:0080182)2.59345278
134positive regulation of interleukin-2 production (GO:0032743)2.58962899
135positive regulation of cell killing (GO:0031343)2.58779676
136mature B cell differentiation (GO:0002335)2.57526423
137regulation of cell killing (GO:0031341)2.56068475
138positive regulation of interleukin-1 secretion (GO:0050716)2.54018106
139regulation of B cell mediated immunity (GO:0002712)2.53946559
140T cell differentiation (GO:0030217)2.52911197
141regulation of immunoglobulin production (GO:0002637)2.51481479
142modulation by symbiont of host cellular process (GO:0044068)2.51051574
143positive regulation of DNA recombination (GO:0045911)2.49927872
144T cell activation involved in immune response (GO:0002286)2.48845740
145positive regulation of interleukin-4 production (GO:0032753)2.48009120
146regulation of leukocyte mediated cytotoxicity (GO:0001910)2.47572280
147cellular extravasation (GO:0045123)2.47481711
148regulation of interleukin-2 production (GO:0032663)2.46496609
149regulation of gamma-delta T cell activation (GO:0046643)2.44524842
150serotonin receptor signaling pathway (GO:0007210)2.43617977
151sulfate transmembrane transport (GO:1902358)2.43002482
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.41555060
153regulation of interleukin-8 secretion (GO:2000482)2.41541183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.92127282
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.59021596
3MYB_26560356_Chip-Seq_TH2_Human3.36410175
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32453332
5GBX2_23144817_ChIP-Seq_PC3_Human3.31273991
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93930329
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.71410180
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.62995779
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56131971
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55447170
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.47616001
12MYB_26560356_Chip-Seq_TH1_Human2.46788933
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46575222
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.33107540
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31984359
16MAF_26560356_Chip-Seq_TH1_Human2.28638726
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24240813
18PCGF2_27294783_Chip-Seq_NPCs_Mouse2.23235240
19GATA3_27048872_Chip-Seq_THYMUS_Human2.19210724
20NFE2_27457419_Chip-Seq_LIVER_Mouse2.13413120
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10328421
22RUNX_20019798_ChIP-Seq_JUKART_Human2.03372035
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02732625
24TAF15_26573619_Chip-Seq_HEK293_Human2.02459928
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00597411
26EZH2_22144423_ChIP-Seq_EOC_Human1.99983702
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92943359
28GATA3_26560356_Chip-Seq_TH2_Human1.92145475
29AR_21572438_ChIP-Seq_LNCaP_Human1.87924070
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.86988426
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86204476
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85626953
33MAF_26560356_Chip-Seq_TH2_Human1.85050055
34SPI1_23547873_ChIP-Seq_NB4_Human1.83322642
35UTX_26944678_Chip-Seq_JUKART_Human1.82769228
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80929172
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76911329
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75745745
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.75191894
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.73996194
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69216083
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.66571960
43P300_19829295_ChIP-Seq_ESCs_Human1.65935709
44E2F1_18555785_Chip-Seq_ESCs_Mouse1.65728856
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65458939
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64821560
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64677081
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.64281835
49SUZ12_18555785_Chip-Seq_ESCs_Mouse1.62919124
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.62653475
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62096886
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61258154
53P53_22387025_ChIP-Seq_ESCs_Mouse1.60461834
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58954524
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.58736316
56CMYC_18555785_Chip-Seq_ESCs_Mouse1.57458084
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53861724
58NMYC_18555785_Chip-Seq_ESCs_Mouse1.52160236
59VDR_22108803_ChIP-Seq_LS180_Human1.51538435
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.50390167
61EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.50103452
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48881876
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47683745
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47680422
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46702732
66RUNX1_27457419_Chip-Seq_LIVER_Mouse1.46680198
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46256212
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45116998
69SMAD4_21799915_ChIP-Seq_A2780_Human1.45011185
70VDR_23849224_ChIP-Seq_CD4+_Human1.44915276
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.44466185
72PU1_27457419_Chip-Seq_LIVER_Mouse1.42962692
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42498513
74P300_18555785_Chip-Seq_ESCs_Mouse1.42030478
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41474211
76SOX2_18555785_Chip-Seq_ESCs_Mouse1.40296571
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39229423
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.38279537
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35709459
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35657692
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.35229675
82ESRRB_18555785_Chip-Seq_ESCs_Mouse1.34743900
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.34629447
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.34309237
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34030495
86ZFX_18555785_Chip-Seq_ESCs_Mouse1.33082216
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30093012
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.29542009
89ER_23166858_ChIP-Seq_MCF-7_Human1.29003289
90RNF2_27304074_Chip-Seq_NSC_Mouse1.28213549
91MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27694602
92FOXP3_21729870_ChIP-Seq_TREG_Human1.27614019
93KLF4_18555785_Chip-Seq_ESCs_Mouse1.27127276
94CTCF_18555785_Chip-Seq_ESCs_Mouse1.24174606
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23521310
96SMAD1_18555785_Chip-Seq_ESCs_Mouse1.23113279
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.22389815
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.22273262
99IRF8_27001747_Chip-Seq_BMDM_Mouse1.19378789
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19201641
101IGF1R_20145208_ChIP-Seq_DFB_Human1.17841997
102SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17712831
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.16361916
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15618727
105MYC_22102868_ChIP-Seq_BL_Human1.15541388
106FUS_26573619_Chip-Seq_HEK293_Human1.13587278
107RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12809667
108EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12809667
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12423136
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10895717
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10895717
112IRF8_22096565_ChIP-ChIP_GC-B_Human1.10486904
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09361240
114TP53_18474530_ChIP-ChIP_U2OS_Human1.08988298
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08495102
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.08268958
117RNF2_27304074_Chip-Seq_ESCs_Mouse1.08210040
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07392194
119CIITA_25753668_ChIP-Seq_RAJI_Human1.06496722
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.06290678
121EST1_17652178_ChIP-ChIP_JURKAT_Human1.06195654
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06132679
123* STAT3_23295773_ChIP-Seq_U87_Human1.06075477
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05961807
125BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05578930
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04375216
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04226229
128TCF4_23295773_ChIP-Seq_U87_Human1.03841655
129SCL_19346495_ChIP-Seq_HPC-7_Human1.03654199
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03090542
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.02639251
132ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01990749
133RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01473054
134TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01219983
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00911434
136SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00512492
137CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99811731
138VDR_24787735_ChIP-Seq_THP-1_Human0.98977326
139GATA3_26560356_Chip-Seq_TH1_Human0.97883108
140TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97494556
141SPI1_23127762_ChIP-Seq_K562_Human0.96235114
142HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95944497
143PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94959335
144CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93516163
145ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91765822
146TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90209683
147YY1_21170310_ChIP-Seq_MESCs_Mouse0.89987558
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88925474
149PU_27001747_Chip-Seq_BMDM_Mouse0.87962683
150HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87935503
151GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87611280
152RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85171746
153SMRT_27268052_Chip-Seq_Bcells_Human0.84046039
154PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83837273
155CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83658914
156FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83373170
157VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83258670
158VDR_24763502_ChIP-Seq_THP-1_Human0.75966136
159STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75471859
160KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.69360661
161STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.69157013
162Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67228738
163STAT1_20625510_ChIP-Seq_HELA_Human0.67151326
164GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.65800635
165CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65426538
166PU.1_20513432_ChIP-Seq_Bcells_Mouse0.64851407
167PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64439347
168KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.64431757
169JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.63005649
170PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62858113
171EGR1_19032775_ChIP-ChIP_M12_Human0.62399662
172TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.62237591
173GATA1_19941827_ChIP-Seq_MEL_Mouse0.62046912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.66986008
2MP0003763_abnormal_thymus_physiology3.46674769
3MP0002277_abnormal_respiratory_mucosa3.21821071
4MP0000566_synostosis2.89704995
5MP0006082_CNS_inflammation2.85243109
6MP0002166_altered_tumor_susceptibility2.82807933
7MP0001835_abnormal_antigen_presentation2.66847350
8MP0004381_abnormal_hair_follicle2.62313401
9MP0003787_abnormal_imprinting2.54059173
10MP0006292_abnormal_olfactory_placode2.43552188
11MP0001790_abnormal_immune_system2.35229205
12MP0005387_immune_system_phenotype2.35229205
13MP0001800_abnormal_humoral_immune2.32723538
14MP0005000_abnormal_immune_tolerance2.27513541
15MP0002933_joint_inflammation2.26028397
16MP0002396_abnormal_hematopoietic_system2.19867698
17MP0002148_abnormal_hypersensitivity_rea2.13978819
18MP0000569_abnormal_digit_pigmentation2.13727639
19MP0003724_increased_susceptibility_to2.06146149
20MP0002723_abnormal_immune_serum2.02810646
21MP0002420_abnormal_adaptive_immunity2.02264462
22MP0001819_abnormal_immune_cell2.01293354
23MP0005310_abnormal_salivary_gland2.01288101
24MP0001188_hyperpigmentation1.99058334
25MP0003300_gastrointestinal_ulcer1.96997577
26MP0005645_abnormal_hypothalamus_physiol1.94491715
27MP0002163_abnormal_gland_morphology1.93815373
28MP0001873_stomach_inflammation1.89430623
29MP0002102_abnormal_ear_morphology1.89430609
30MP0002452_abnormal_antigen_presenting1.88660722
31MP0005257_abnormal_intraocular_pressure1.71409591
32MP0004510_myositis1.71269356
33MP0001501_abnormal_sleep_pattern1.69878250
34MP0005025_abnormal_response_to1.69783944
35MP0003045_fibrosis1.66083448
36MP0009785_altered_susceptibility_to1.65596179
37MP0009333_abnormal_splenocyte_physiolog1.60480522
38MP0003136_yellow_coat_color1.60253390
39MP0001851_eye_inflammation1.60086390
40MP0001986_abnormal_taste_sensitivity1.59747643
41MP0002398_abnormal_bone_marrow1.59587408
42MP0000716_abnormal_immune_system1.56926668
43MP0002419_abnormal_innate_immunity1.56473850
44MP0001348_abnormal_lacrimal_gland1.52743092
45MP0000703_abnormal_thymus_morphology1.52682742
46MP0003436_decreased_susceptibility_to1.43592839
47MP0002405_respiratory_system_inflammati1.42661800
48MP0002735_abnormal_chemical_nociception1.33224628
49MP0002998_abnormal_bone_remodeling1.32506348
50MP0004742_abnormal_vestibular_system1.28730624
51MP0001486_abnormal_startle_reflex1.27676185
52MP0005075_abnormal_melanosome_morpholog1.27632196
53MP0008469_abnormal_protein_level1.20915052
54MP0002138_abnormal_hepatobiliary_system1.19599177
55MP0002722_abnormal_immune_system1.18357824
56MP0000383_abnormal_hair_follicle1.14253076
57MP0005379_endocrine/exocrine_gland_phen1.13899123
58MP0003866_abnormal_defecation1.09180560
59MP0002429_abnormal_blood_cell1.08102089
60MP0000689_abnormal_spleen_morphology1.07829063
61MP0001853_heart_inflammation1.05112295
62MP0002132_abnormal_respiratory_system1.04213403
63MP0005409_darkened_coat_color1.01905794
64MP0004947_skin_inflammation1.01302996
65MP0005646_abnormal_pituitary_gland1.00945348
66MP0000685_abnormal_immune_system1.00448734
67MP0001845_abnormal_inflammatory_respons1.00394218
68MP0008877_abnormal_DNA_methylation0.99741027
69MP0001533_abnormal_skeleton_physiology0.99042311
70MP0001346_abnormal_lacrimal_gland0.98270570
71MP0005464_abnormal_platelet_physiology0.96230836
72MP0002736_abnormal_nociception_after0.95896198
73MP0003880_abnormal_central_pattern0.94198098
74MP0009763_increased_sensitivity_to0.93710034
75MP0005171_absent_coat_pigmentation0.93549484
76MP0002006_tumorigenesis0.92450636
77MP0005423_abnormal_somatic_nervous0.88539826
78MP0009745_abnormal_behavioral_response0.86789111
79MP0002572_abnormal_emotion/affect_behav0.85603773
80MP0010155_abnormal_intestine_physiology0.85172331
81MP0000490_abnormal_crypts_of0.84773048
82MP0008004_abnormal_stomach_pH0.84689119
83MP0002019_abnormal_tumor_incidence0.84650036
84MP0000465_gastrointestinal_hemorrhage0.84071462
85MP0005408_hypopigmentation0.82763847
86MP0000858_altered_metastatic_potential0.82515000
87MP0009250_abnormal_appendicular_skeleto0.80178768
88MP0001968_abnormal_touch/_nociception0.80084820
89MP0003448_altered_tumor_morphology0.79420092
90MP0005377_hearing/vestibular/ear_phenot0.78393966
91MP0003878_abnormal_ear_physiology0.78393966
92MP0002693_abnormal_pancreas_physiology0.78258619
93MP0003303_peritoneal_inflammation0.75148646
94MP0003868_abnormal_feces_composition0.74658225
95MP0002009_preneoplasia0.73813349
96MP0003828_pulmonary_edema0.71737494
97MP0004142_abnormal_muscle_tone0.71412961
98MP0001963_abnormal_hearing_physiology0.70468892
99MP0000015_abnormal_ear_pigmentation0.70434114
100MP0001299_abnormal_eye_distance/0.70005912
101MP0002098_abnormal_vibrissa_morphology0.69938751
102MP0005584_abnormal_enzyme/coenzyme_acti0.69338277
103MP0003795_abnormal_bone_structure0.69265084
104MP0003941_abnormal_skin_development0.68745703
105MP0002876_abnormal_thyroid_physiology0.67923931
106MP0000026_abnormal_inner_ear0.66920029
107MP0005551_abnormal_eye_electrophysiolog0.66345188
108MP0005390_skeleton_phenotype0.65807178
109MP0001663_abnormal_digestive_system0.65148784
110MP0009764_decreased_sensitivity_to0.64812090
111MP0001502_abnormal_circadian_rhythm0.64761239
112MP0000372_irregular_coat_pigmentation0.63540833
113MP0001919_abnormal_reproductive_system0.62668103
114MP0008873_increased_physiological_sensi0.61349519
115MP0003183_abnormal_peptide_metabolism0.59666391
116MP0009765_abnormal_xenobiotic_induced0.57079188
117MP0008872_abnormal_physiological_respon0.55616840
118MP0008057_abnormal_DNA_replication0.50918922
119MP0002877_abnormal_melanocyte_morpholog0.49852201
120MP0000371_diluted_coat_color0.46408394
121MP0002168_other_aberrant_phenotype0.45641699
122MP0005174_abnormal_tail_pigmentation0.45415028
123MP0008260_abnormal_autophagy0.44966712
124MP0002136_abnormal_kidney_physiology0.44734894
125MP0003646_muscle_fatigue0.44134368
126MP0001765_abnormal_ion_homeostasis0.43628931
127MP0003786_premature_aging0.43337516
128MP0005166_decreased_susceptibility_to0.41727142
129MP0002095_abnormal_skin_pigmentation0.38707591
130MP0008961_abnormal_basal_metabolism0.38138930
131MP0003806_abnormal_nucleotide_metabolis0.38136188
132MP0000920_abnormal_myelination0.37591436
133MP0001958_emphysema0.35796296
134MP0005319_abnormal_enzyme/_coenzyme0.35620604

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.78296713
2Optic neuritis (HP:0100653)4.78296713
3Abnormality of T cell physiology (HP:0011840)4.09531092
4Hypoproteinemia (HP:0003075)4.01145404
5Abnormality of the prostate (HP:0008775)3.83502649
6Recurrent viral infections (HP:0004429)3.81231509
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.79388395
8Prostate neoplasm (HP:0100787)3.71985338
9Myositis (HP:0100614)3.70655628
10Orchitis (HP:0100796)3.69800462
11Stomatitis (HP:0010280)3.67650035
12Autoimmune thrombocytopenia (HP:0001973)3.61287245
13Chromsome breakage (HP:0040012)3.42340488
14Gastrointestinal infarctions (HP:0005244)3.35740159
15Autoimmune hemolytic anemia (HP:0001890)3.34585419
16Abnormality of incisor morphology (HP:0011063)3.30746167
17Obstructive lung disease (HP:0006536)3.23115482
18Chronic obstructive pulmonary disease (HP:0006510)3.23115482
19Abnormality of T cell number (HP:0011839)3.19188130
20Increased IgM level (HP:0003496)3.16216250
21Thyroiditis (HP:0100646)3.12236143
22T lymphocytopenia (HP:0005403)3.10055069
23Aplastic anemia (HP:0001915)3.06861077
24Aplasia cutis congenita (HP:0001057)3.06314717
25Fatigue (HP:0012378)3.05290837
26Agammaglobulinemia (HP:0004432)3.04942270
27Keratoconjunctivitis sicca (HP:0001097)3.00635123
28Abnormality of macrophages (HP:0004311)2.99472725
29Chronic diarrhea (HP:0002028)2.92723179
30Recurrent bacterial skin infections (HP:0005406)2.92125017
31Hypoplasia of the thymus (HP:0000778)2.89467484
32Pulmonary infiltrates (HP:0002113)2.86282397
33Eczematoid dermatitis (HP:0000976)2.85029928
34Septo-optic dysplasia (HP:0100842)2.82802776
35Recurrent cutaneous fungal infections (HP:0011370)2.81027031
36Chronic mucocutaneous candidiasis (HP:0002728)2.81027031
37Recurrent skin infections (HP:0001581)2.80684423
38Hemoptysis (HP:0002105)2.79947489
39Parakeratosis (HP:0001036)2.78760299
40Hypergammaglobulinemia (HP:0010702)2.77899163
41Pustule (HP:0200039)2.77521089
42Keratoconjunctivitis (HP:0001096)2.77416899
43Hypochromic anemia (HP:0001931)2.77202645
44Cheilitis (HP:0100825)2.76722062
45Febrile seizures (HP:0002373)2.74541108
46Acute hepatic failure (HP:0006554)2.69044020
47Vasculitis (HP:0002633)2.69003492
48Abnormality of the pons (HP:0007361)2.67490309
49Chest pain (HP:0100749)2.65523408
50Severe combined immunodeficiency (HP:0004430)2.64782770
51Meningitis (HP:0001287)2.61692870
52Encephalitis (HP:0002383)2.61023081
53Patchy hypopigmentation of hair (HP:0011365)2.59513659
54Duplicated collecting system (HP:0000081)2.58212237
55White forelock (HP:0002211)2.57417887
56Alveolar cell carcinoma (HP:0006519)2.55444481
57Renal cortical cysts (HP:0000803)2.53619536
58Lymphopenia (HP:0001888)2.53181441
59Abnormality of the renal collecting system (HP:0004742)2.52104049
60Recurrent fungal infections (HP:0002841)2.51929068
61Abnormality of male internal genitalia (HP:0000022)2.50166974
62Abnormal hair whorl (HP:0010721)2.50100338
63Lymphoma (HP:0002665)2.47990249
64Gangrene (HP:0100758)2.45466112
65Recurrent sinusitis (HP:0011108)2.43741367
66Chronic otitis media (HP:0000389)2.40230228
67IgG deficiency (HP:0004315)2.37981218
68Hypoplasia of the pons (HP:0012110)2.37768278
69Eosinophilia (HP:0001880)2.37560444
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.35554662
71Abnormality of eosinophils (HP:0001879)2.34868079
72Recurrent pneumonia (HP:0006532)2.34596745
73Abnormality of the nasal septum (HP:0000419)2.32048501
74Neoplasm of the tracheobronchial system (HP:0100552)2.31136349
75Conical tooth (HP:0000698)2.30300222
76Bronchitis (HP:0012387)2.28027031
77IgA deficiency (HP:0002720)2.23860104
78Glomerulopathy (HP:0100820)2.20241971
79Combined immunodeficiency (HP:0005387)2.15719842
80Elevated erythrocyte sedimentation rate (HP:0003565)2.14238362
81Lip pit (HP:0100267)2.13064265
82Increased IgE level (HP:0003212)2.10945028
83Keratitis (HP:0000491)2.09964859
84Panhypogammaglobulinemia (HP:0003139)2.09925666
85Skin rash (HP:0000988)2.09593284
86Hemiplegia (HP:0002301)2.09381341
87Recurrent abscess formation (HP:0002722)2.08943370
88Absent/shortened dynein arms (HP:0200106)2.08525268
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.08525268
90Arterial thrombosis (HP:0004420)2.07607481
91Anorexia (HP:0002039)2.05342564
92Urticaria (HP:0001025)2.03564431
93IgM deficiency (HP:0002850)2.03047674
94Abnormality of T cells (HP:0002843)2.02846828
95Ectopic kidney (HP:0000086)2.02219131
96Congenital sensorineural hearing impairment (HP:0008527)2.01720870
97Joint swelling (HP:0001386)2.00124295
98Verrucae (HP:0200043)1.97311633
99Papilloma (HP:0012740)1.97311633
1003-Methylglutaconic aciduria (HP:0003535)1.96678375
101Congenital stationary night blindness (HP:0007642)1.96328927
102Hypochromic microcytic anemia (HP:0004840)1.94234355
103Anomalous pulmonary venous return (HP:0010772)1.94098074
104Fair hair (HP:0002286)1.92208563
105Abnormality of the intervertebral disk (HP:0005108)1.92052252
106Abnormality of the pleura (HP:0002103)1.91836763
107Spontaneous hematomas (HP:0007420)1.91212259
108Focal motor seizures (HP:0011153)1.90408594
109Abnormal delayed hypersensitivity skin test (HP:0002963)1.87876131
110Osteomalacia (HP:0002749)1.87817943
111Mediastinal lymphadenopathy (HP:0100721)1.87520310
112Submucous cleft hard palate (HP:0000176)1.87394427
113Stomach cancer (HP:0012126)1.87185775
114Abnormality of the incisor (HP:0000676)1.86689412
115Ureteral stenosis (HP:0000071)1.85933683
116Abnormality of DNA repair (HP:0003254)1.85823245
117Granulocytopenia (HP:0001913)1.85622659
118Microcytic anemia (HP:0001935)1.84760144
119Ureteral obstruction (HP:0006000)1.84387446
120Leukocytosis (HP:0001974)1.84242119
121Decreased central vision (HP:0007663)1.83421255
122Abnormality of B cell number (HP:0010975)1.82381990
123B lymphocytopenia (HP:0010976)1.82381990
124Abnormality of the renal cortex (HP:0011035)1.82092111
125Absent eyebrow (HP:0002223)1.81528706
126Recurrent bronchitis (HP:0002837)1.81407505
127Neutropenia (HP:0001875)1.79570168
128Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79190428
129Abnormality of the preputium (HP:0100587)1.78293428
130Clubbing of toes (HP:0100760)1.77993750
131Inflammation of the large intestine (HP:0002037)1.77893311
132Pancytopenia (HP:0001876)1.77151423
133Oral leukoplakia (HP:0002745)1.76632501
134Chronic hepatic failure (HP:0100626)1.76526486
135Pulmonary embolism (HP:0002204)1.75901386
136Abnormality of the parietal bone (HP:0002696)1.75261981
137Polyneuropathy (HP:0001271)1.74195873
138Gingivitis (HP:0000230)1.73683111
139Absent septum pellucidum (HP:0001331)1.73079681
140Slow saccadic eye movements (HP:0000514)1.72432699
141Aplasia/Hypoplasia of the uvula (HP:0010293)1.70308244
142Generalized hypopigmentation of hair (HP:0011358)1.69739437
143Abnormality of the fingertips (HP:0001211)1.69230127
144Nasolacrimal duct obstruction (HP:0000579)1.68209000
145Papilledema (HP:0001085)1.61829627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.38557311
2SIK33.73279271
3MAP3K142.80544600
4MAP4K12.54219269
5BLK2.35372797
6ITK2.20295645
7SIK22.17071670
8CASK2.14114439
9GRK71.90289380
10KDR1.81098560
11ADRBK21.78418876
12CAMKK21.76606272
13TNIK1.70915511
14ZAK1.65116530
15TEC1.55432979
16JAK11.53827423
17JAK31.44707379
18IRAK41.43833943
19EIF2AK21.40206552
20MAP2K31.37687087
21LCK1.36166945
22INSRR1.34977389
23PRPF4B1.32921799
24IKBKE1.30464816
25NUAK11.29518042
26ZAP701.28787442
27CDK81.27588942
28CDK31.26552784
29GRK61.25695189
30FRK1.24952125
31MST41.24453630
32MKNK21.24204951
33TGFBR21.21028548
34MAP3K131.19062257
35PIM11.16748913
36PRKCQ1.16188461
37TNK21.15408367
38MAP3K111.13754666
39MAP2K61.08278136
40MAP3K31.08029428
41IKBKB1.06518797
42BMPR21.06309530
43CSK1.05223373
44MARK31.04442139
45SYK1.03598340
46STK101.00287040
47CDK120.97654957
48CLK10.97096471
49MAP3K120.96705748
50TAOK10.95150258
51HCK0.94179395
52TYK20.92988242
53LYN0.90392533
54TAOK20.90023293
55NTRK30.87776375
56BRD40.87552713
57KIT0.82986932
58NEK60.80876471
59BMPR1B0.80629676
60TSSK60.80342506
61YES10.80168874
62CHUK0.79355713
63JAK20.79006095
64PASK0.78705069
65PRKCH0.78656162
66PKN10.76091383
67PLK20.75334044
68TESK20.74529165
69DMPK0.73607460
70MAPKAPK30.72760899
71BCR0.72672626
72MAP2K70.72488544
73MAPK130.72031496
74FES0.71803780
75EPHA30.70757701
76BCKDK0.70388369
77SGK20.69930297
78CAMKK10.69403777
79RIPK40.67696061
80IRAK30.67369138
81HIPK20.65921744
82FGFR40.65153590
83MAPK70.63963049
84PIK3CA0.62818647
85NLK0.62536654
86GRK10.62475637
87MUSK0.62106021
88PIK3CG0.61537737
89SRPK10.61314386
90EPHB10.59900052
91IRAK10.59123966
92MKNK10.58826864
93BTK0.58266085
94AKT30.55656737
95TAOK30.55592545
96FGR0.54400737
97WNK10.53677007
98VRK10.53584529
99FYN0.53060689
100MAP3K10.52103497
101NTRK20.51813490
102STK110.51559137
103SIK10.51206960
104PDK10.51194442
105STK240.51095497
106TYRO30.50804186
107IGF1R0.50091263
108FGFR30.49563695
109PTK2B0.49054498
110PRKCE0.46401368
111MARK20.45089487
112STK38L0.44992868
113RPS6KA50.43588434
114INSR0.42857912
115TLK10.40892410
116MAPKAPK20.40758124
117CSF1R0.40629151
118TBK10.40075314
119SGK10.37929093
120STK40.37615523
121PRKG10.37284804
122PRKD20.36298566
123MAPK110.35180876
124SGK30.34536061
125CDK40.33354907
126SGK2230.33009094
127SGK4940.33009094
128NEK90.32337071
129IRAK20.31631769
130CAMK10.31503902
131PAK30.30651043
132EIF2AK30.25226295
133WNK40.23857931
134CDK190.21218052
135GRK50.20443435
136MAPK120.19852236
137MATK0.18468682
138MAP3K50.17308949
139PRKCD0.16768359
140LRRK20.14887234
141PDGFRB0.11241858
142DAPK10.11184744

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.95571240
2Graft-versus-host disease_Homo sapiens_hsa053323.62857535
3Autoimmune thyroid disease_Homo sapiens_hsa053203.54730435
4Allograft rejection_Homo sapiens_hsa053303.30073362
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.04419137
6T cell receptor signaling pathway_Homo sapiens_hsa046602.70298456
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.58760694
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.34080040
9Hematopoietic cell lineage_Homo sapiens_hsa046402.31114117
10Measles_Homo sapiens_hsa051622.16781488
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.11408264
12Proteasome_Homo sapiens_hsa030502.11167894
13Asthma_Homo sapiens_hsa053102.00548432
14Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.83529002
15Nicotine addiction_Homo sapiens_hsa050331.70990000
16* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.56219051
17Rheumatoid arthritis_Homo sapiens_hsa053231.53043803
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50743805
19Osteoclast differentiation_Homo sapiens_hsa043801.45823082
20Leishmaniasis_Homo sapiens_hsa051401.44876819
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40346276
22Staphylococcus aureus infection_Homo sapiens_hsa051501.35645688
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.34657272
24Type I diabetes mellitus_Homo sapiens_hsa049401.31894746
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17729462
26Chemokine signaling pathway_Homo sapiens_hsa040621.15338198
27Antigen processing and presentation_Homo sapiens_hsa046121.11625561
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11304593
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09989050
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09662050
31Malaria_Homo sapiens_hsa051441.05091992
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00999230
33Fanconi anemia pathway_Homo sapiens_hsa034601.00993735
34African trypanosomiasis_Homo sapiens_hsa051431.00752541
35Morphine addiction_Homo sapiens_hsa050321.00646871
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98647327
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96614850
38Herpes simplex infection_Homo sapiens_hsa051680.93976689
39Viral myocarditis_Homo sapiens_hsa054160.92901419
40Serotonergic synapse_Homo sapiens_hsa047260.91790442
41Taste transduction_Homo sapiens_hsa047420.91598072
42Epstein-Barr virus infection_Homo sapiens_hsa051690.90254388
43B cell receptor signaling pathway_Homo sapiens_hsa046620.89637255
44TNF signaling pathway_Homo sapiens_hsa046680.86793993
45Phototransduction_Homo sapiens_hsa047440.86190054
46Influenza A_Homo sapiens_hsa051640.76632940
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74627737
48Tuberculosis_Homo sapiens_hsa051520.73632687
49Toxoplasmosis_Homo sapiens_hsa051450.73256359
50HTLV-I infection_Homo sapiens_hsa051660.70847978
51Regulation of autophagy_Homo sapiens_hsa041400.70735889
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70331229
53Calcium signaling pathway_Homo sapiens_hsa040200.70008657
54Hepatitis B_Homo sapiens_hsa051610.69424602
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69079398
56Non-homologous end-joining_Homo sapiens_hsa034500.67635231
57Axon guidance_Homo sapiens_hsa043600.67399451
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66265560
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64841465
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64835614
61Olfactory transduction_Homo sapiens_hsa047400.62933924
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62902679
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62513198
64Legionellosis_Homo sapiens_hsa051340.62071209
65cAMP signaling pathway_Homo sapiens_hsa040240.60802028
66Pancreatic cancer_Homo sapiens_hsa052120.60573218
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.59817762
68Sphingolipid metabolism_Homo sapiens_hsa006000.59123453
69Ras signaling pathway_Homo sapiens_hsa040140.59111039
70Viral carcinogenesis_Homo sapiens_hsa052030.58790321
71Basal transcription factors_Homo sapiens_hsa030220.58426426
72Glutamatergic synapse_Homo sapiens_hsa047240.57863489
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56150671
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55053090
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54859415
76MAPK signaling pathway_Homo sapiens_hsa040100.54037440
77Pertussis_Homo sapiens_hsa051330.53237811
78Renin secretion_Homo sapiens_hsa049240.49937180
79Prolactin signaling pathway_Homo sapiens_hsa049170.49461978
80Protein export_Homo sapiens_hsa030600.49267729
81Circadian entrainment_Homo sapiens_hsa047130.48549338
82Rap1 signaling pathway_Homo sapiens_hsa040150.45197314
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45133002
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44100992
85Platelet activation_Homo sapiens_hsa046110.43995226
86Inositol phosphate metabolism_Homo sapiens_hsa005620.43798720
87Homologous recombination_Homo sapiens_hsa034400.43703806
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43596081
89GABAergic synapse_Homo sapiens_hsa047270.43402943
90Oxytocin signaling pathway_Homo sapiens_hsa049210.42944523
91Apoptosis_Homo sapiens_hsa042100.41893199
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41830970
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40765893
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40708289
95Hepatitis C_Homo sapiens_hsa051600.40568963
96Non-small cell lung cancer_Homo sapiens_hsa052230.40163574
97Salmonella infection_Homo sapiens_hsa051320.40040866
98Phagosome_Homo sapiens_hsa041450.37511570
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36934569
100Ether lipid metabolism_Homo sapiens_hsa005650.36630992
101VEGF signaling pathway_Homo sapiens_hsa043700.36420136
102Salivary secretion_Homo sapiens_hsa049700.36081851
103Melanoma_Homo sapiens_hsa052180.35917695
104RNA degradation_Homo sapiens_hsa030180.34927645
105Dilated cardiomyopathy_Homo sapiens_hsa054140.34852039
106Cholinergic synapse_Homo sapiens_hsa047250.33536504
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33149240
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32637976
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32441346
110Wnt signaling pathway_Homo sapiens_hsa043100.32319889
111Linoleic acid metabolism_Homo sapiens_hsa005910.31693260
112Cocaine addiction_Homo sapiens_hsa050300.31600710
113Shigellosis_Homo sapiens_hsa051310.31446429
114Acute myeloid leukemia_Homo sapiens_hsa052210.31194007
115FoxO signaling pathway_Homo sapiens_hsa040680.30783326
116N-Glycan biosynthesis_Homo sapiens_hsa005100.30062330
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29716733
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27583450
119RNA polymerase_Homo sapiens_hsa030200.24066692
120Endocytosis_Homo sapiens_hsa041440.21480624
121Glycerolipid metabolism_Homo sapiens_hsa005610.19388786
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.18792201
123Collecting duct acid secretion_Homo sapiens_hsa049660.14722886
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.14638693
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14227384
126Sulfur metabolism_Homo sapiens_hsa009200.12847034
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.11630477
128Insulin resistance_Homo sapiens_hsa049310.11471316
129Circadian rhythm_Homo sapiens_hsa047100.11132618
130Spliceosome_Homo sapiens_hsa030400.09439372
131Nitrogen metabolism_Homo sapiens_hsa009100.07174628
132ABC transporters_Homo sapiens_hsa020100.06951441
133Oxidative phosphorylation_Homo sapiens_hsa001900.05172306
134Chronic myeloid leukemia_Homo sapiens_hsa052200.03451004
135p53 signaling pathway_Homo sapiens_hsa041150.02996531
136Ribosome_Homo sapiens_hsa030100.02784702
137Small cell lung cancer_Homo sapiens_hsa052220.02068196

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