TIGD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.29992246
2epithelial cilium movement (GO:0003351)5.15315246
3axonemal dynein complex assembly (GO:0070286)4.91576282
4presynaptic membrane assembly (GO:0097105)4.74349829
5cilium movement (GO:0003341)4.69365757
6postsynaptic membrane organization (GO:0001941)4.48679998
7neuron cell-cell adhesion (GO:0007158)4.44025511
8cilium or flagellum-dependent cell motility (GO:0001539)4.40004747
9intraciliary transport (GO:0042073)4.37629582
10negative regulation of synaptic transmission, GABAergic (GO:0032229)4.09625169
11presynaptic membrane organization (GO:0097090)4.07788147
12G-protein coupled receptor internalization (GO:0002031)3.94176246
13somite development (GO:0061053)3.80981471
14microtubule polymerization or depolymerization (GO:0031109)3.70599487
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.60696465
16nonmotile primary cilium assembly (GO:0035058)3.58935688
17cilium organization (GO:0044782)3.53367091
18serotonin receptor signaling pathway (GO:0007210)3.52129777
19superoxide anion generation (GO:0042554)3.50744887
20cilium assembly (GO:0042384)3.49665823
21response to pheromone (GO:0019236)3.48768496
22centriole replication (GO:0007099)3.47893421
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43790970
24vocalization behavior (GO:0071625)3.43722440
25inner ear receptor stereocilium organization (GO:0060122)3.43187092
26DNA damage response, detection of DNA damage (GO:0042769)3.36415999
27cerebral cortex radially oriented cell migration (GO:0021799)3.33227149
28cilium morphogenesis (GO:0060271)3.32475863
29spermatid nucleus differentiation (GO:0007289)3.32306592
30righting reflex (GO:0060013)3.31248055
31startle response (GO:0001964)3.29727081
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.28602113
33C4-dicarboxylate transport (GO:0015740)3.27774897
34regulation of cilium movement (GO:0003352)3.25643297
35opioid receptor signaling pathway (GO:0038003)3.23833927
36glutamate receptor signaling pathway (GO:0007215)3.23784461
37DNA double-strand break processing (GO:0000729)3.20279560
38response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.19162853
39motile cilium assembly (GO:0044458)3.18526752
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14074636
41cullin deneddylation (GO:0010388)3.11487758
42peptidyl-histidine modification (GO:0018202)3.09866567
43centriole assembly (GO:0098534)3.02850910
44regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.01997725
45attachment of spindle microtubules to kinetochore (GO:0008608)3.01925029
46protein localization to synapse (GO:0035418)3.01882045
47skeletal muscle contraction (GO:0003009)3.01434964
48regulation of respiratory system process (GO:0044065)3.00699071
49regulation of timing of cell differentiation (GO:0048505)3.00300361
50establishment of planar polarity (GO:0001736)2.96644296
51establishment of tissue polarity (GO:0007164)2.96644296
52chromatin remodeling at centromere (GO:0031055)2.95517914
53sperm motility (GO:0030317)2.94222849
54pyrimidine nucleobase catabolic process (GO:0006208)2.94016698
55protein localization to kinetochore (GO:0034501)2.92493727
56cell proliferation in forebrain (GO:0021846)2.91875882
57neurotransmitter-gated ion channel clustering (GO:0072578)2.91859437
58response to nitrosative stress (GO:0051409)2.91402873
59neuronal action potential propagation (GO:0019227)2.91218459
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.90346418
61regulation of glutamate secretion (GO:0014048)2.90178717
62limb bud formation (GO:0060174)2.90045525
63regulation of glutamate receptor signaling pathway (GO:1900449)2.89008911
64negative regulation of transcription regulatory region DNA binding (GO:2000678)2.88449067
65adenosine metabolic process (GO:0046085)2.87590314
66CENP-A containing nucleosome assembly (GO:0034080)2.86222291
67positive regulation of synapse assembly (GO:0051965)2.85547697
68auditory receptor cell stereocilium organization (GO:0060088)2.85291553
69gamma-aminobutyric acid signaling pathway (GO:0007214)2.84905826
70negative regulation of protein localization to cell surface (GO:2000009)2.84151438
71kinetochore organization (GO:0051383)2.84070118
72histone exchange (GO:0043486)2.84008824
73developmental pigmentation (GO:0048066)2.83188260
74neuron recognition (GO:0008038)2.82459136
75retina layer formation (GO:0010842)2.82274550
76cyclic nucleotide catabolic process (GO:0009214)2.80259486
77cAMP catabolic process (GO:0006198)2.79893300
78calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.78131242
79olfactory bulb development (GO:0021772)2.77698274
80positive regulation of action potential (GO:0045760)2.77687463
81protein polyglutamylation (GO:0018095)2.77524788
82regulation of centriole replication (GO:0046599)2.76695243
83cranial nerve morphogenesis (GO:0021602)2.76332998
84mesenchymal cell differentiation involved in renal system development (GO:2001012)2.75657783
85mesenchymal cell differentiation involved in kidney development (GO:0072161)2.75657783
86sympathetic nervous system development (GO:0048485)2.74814844
87behavioral response to ethanol (GO:0048149)2.72872796
88reflex (GO:0060004)2.69888725
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67502831
90DNA ligation (GO:0006266)2.66942686
91sarcoplasmic reticulum calcium ion transport (GO:0070296)2.66837860
92retinal rod cell development (GO:0046548)2.66771082
93axoneme assembly (GO:0035082)2.66099645
94neuron-neuron synaptic transmission (GO:0007270)2.63858700
95positive regulation of mitochondrial fission (GO:0090141)2.63544233
96cellular component assembly involved in morphogenesis (GO:0010927)2.63076777
97resolution of meiotic recombination intermediates (GO:0000712)2.61008695
98kinetochore assembly (GO:0051382)2.60613030
99retinal ganglion cell axon guidance (GO:0031290)2.60530368
100protein deneddylation (GO:0000338)2.59794540
101limb development (GO:0060173)2.59274451
102appendage development (GO:0048736)2.59274451
103regulation of synapse assembly (GO:0051963)2.59066184
104synaptic transmission, glutamatergic (GO:0035249)2.58884265
105photoreceptor cell maintenance (GO:0045494)2.58673449
106regulation of development, heterochronic (GO:0040034)2.58669994
107short-term memory (GO:0007614)2.58165962
108DNA integration (GO:0015074)2.57369986
109DNA topological change (GO:0006265)2.54300821
110replication fork processing (GO:0031297)2.53716622
111positive regulation of uterine smooth muscle contraction (GO:0070474)2.52967394
112negative regulation of oligodendrocyte differentiation (GO:0048715)2.52056450
113response to epinephrine (GO:0071871)2.51849512
114regulation of cell communication by electrical coupling (GO:0010649)2.51314432
115microtubule anchoring (GO:0034453)2.50826451
116protein localization to chromosome, centromeric region (GO:0071459)2.50059889
117microtubule depolymerization (GO:0007019)2.49905136
118spinal cord association neuron differentiation (GO:0021527)2.49736586
119regulation of respiratory gaseous exchange (GO:0043576)2.49585540
120regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.48705901
121cranial nerve structural organization (GO:0021604)2.48288561
122negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47882489
123negative regulation of DNA-dependent DNA replication (GO:2000104)2.45392588
124atrial cardiac muscle cell action potential (GO:0086014)2.44929131
125regulation of pigment cell differentiation (GO:0050932)2.44557118
126regulation of DNA endoreduplication (GO:0032875)2.43035319
127cellular response to epinephrine stimulus (GO:0071872)2.41988469
128negative regulation of homotypic cell-cell adhesion (GO:0034111)2.41901008
129glycerophospholipid catabolic process (GO:0046475)2.41775036
130negative regulation of amino acid transport (GO:0051956)2.41764408
131smoothened signaling pathway (GO:0007224)2.41004577
132regulation of platelet aggregation (GO:0090330)2.40787961
133positive regulation of protein homodimerization activity (GO:0090073)2.40581087
134positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.40482930
135mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.40482930
136lateral sprouting from an epithelium (GO:0060601)2.40314104
137regulation of somitogenesis (GO:0014807)2.39838346
138DNA replication-independent nucleosome organization (GO:0034724)2.38490198
139DNA replication-independent nucleosome assembly (GO:0006336)2.38490198
140transmission of nerve impulse (GO:0019226)2.38228505
141regulation of non-canonical Wnt signaling pathway (GO:2000050)2.38161257
142cholesterol biosynthetic process (GO:0006695)2.37197422
143regulation of synapse maturation (GO:0090128)2.37142836
144positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.36993419
145keratinocyte development (GO:0003334)2.36642596
146determination of left/right symmetry (GO:0007368)2.36142878
147histone mRNA metabolic process (GO:0008334)2.35729611
148determination of bilateral symmetry (GO:0009855)2.35044127
149forebrain neuron differentiation (GO:0021879)2.34592275
150lung-associated mesenchyme development (GO:0060484)2.34288990
151left/right axis specification (GO:0070986)2.34236106
152cellular response to cholesterol (GO:0071397)2.34132604
153kidney morphogenesis (GO:0060993)2.33115132
154regulation of excitatory postsynaptic membrane potential (GO:0060079)2.32494165
155RNA localization (GO:0006403)2.32233413
156female gonad development (GO:0008585)2.32159986
157negative regulation of astrocyte differentiation (GO:0048712)2.31618770
158artery development (GO:0060840)2.31516315
159neural tube formation (GO:0001841)2.31448915
160regulation of synaptic transmission, GABAergic (GO:0032228)2.31261260
161specification of symmetry (GO:0009799)2.31014123
162cerebellar Purkinje cell differentiation (GO:0021702)2.30989017
163acrosome reaction (GO:0007340)2.30755003
164spinal cord development (GO:0021510)2.29335026
165DNA catabolic process, exonucleolytic (GO:0000738)2.29187260
166negative regulation of myoblast differentiation (GO:0045662)2.28021322
167long-chain fatty acid biosynthetic process (GO:0042759)2.27383575
168ventricular system development (GO:0021591)2.27191453
169activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.27169701
170regulation of synaptic transmission, glutamatergic (GO:0051966)2.27087660
171negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.26916945
172negative regulation of translation, ncRNA-mediated (GO:0040033)2.26916945
173regulation of translation, ncRNA-mediated (GO:0045974)2.26916945
174negative regulation of cytosolic calcium ion concentration (GO:0051481)2.26486684
175protein localization to cilium (GO:0061512)2.25644849
176axonal fasciculation (GO:0007413)2.25445275
177cornea development in camera-type eye (GO:0061303)2.24666703
178adrenergic receptor signaling pathway (GO:0071875)2.24633700
179head development (GO:0060322)2.24481962
180modulation by virus of host process (GO:0019054)2.24247862
181regulation of centrosome duplication (GO:0010824)2.23852510
182metaphase plate congression (GO:0051310)2.23609371
183negative regulation of dendrite development (GO:2000171)2.23353642
184regulation of inositol phosphate biosynthetic process (GO:0010919)2.23194536
185sterol biosynthetic process (GO:0016126)2.22980081
186membrane hyperpolarization (GO:0060081)2.22642359
187negative regulation of DNA recombination (GO:0045910)2.22573264
188regulation of uterine smooth muscle contraction (GO:0070472)2.22520006
189positive regulation of meiosis (GO:0045836)2.21945642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.46131454
2GBX2_23144817_ChIP-Seq_PC3_Human4.10908430
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.18924629
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79844268
5ZNF274_21170338_ChIP-Seq_K562_Hela2.73746634
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54301306
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49112443
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.47575067
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.44294127
10TAF15_26573619_Chip-Seq_HEK293_Human2.43041193
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.36546450
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35762371
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.27731274
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.23173903
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.15456122
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.14623769
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14290406
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13084922
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12520700
20SUZ12_27294783_Chip-Seq_NPCs_Mouse2.10217036
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07191890
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.05641320
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05384803
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04881901
25VDR_22108803_ChIP-Seq_LS180_Human2.00074990
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.98757721
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98669675
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95250523
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95250523
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.94219519
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93409908
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91889109
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89820624
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89293757
35ELK1_19687146_ChIP-ChIP_HELA_Human1.88886012
36P300_19829295_ChIP-Seq_ESCs_Human1.86301443
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.78656542
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78219741
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76597756
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76154744
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.76080300
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75689287
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.74081605
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.70482767
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.70475262
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.70016233
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68790245
48RNF2_27304074_Chip-Seq_NSC_Mouse1.67514225
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66932550
50P53_22387025_ChIP-Seq_ESCs_Mouse1.66026805
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65635098
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.64871682
53E2F1_18555785_Chip-Seq_ESCs_Mouse1.63866269
54SUZ12_18555785_Chip-Seq_ESCs_Mouse1.63308795
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60000357
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59380513
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59281448
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.57755138
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55998114
60EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.55937474
61FUS_26573619_Chip-Seq_HEK293_Human1.55822387
62IGF1R_20145208_ChIP-Seq_DFB_Human1.55219186
63STAT3_18555785_Chip-Seq_ESCs_Mouse1.54777403
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54637691
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.54281290
66SMAD4_21799915_ChIP-Seq_A2780_Human1.52570916
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50626044
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.49967381
69AR_21572438_ChIP-Seq_LNCaP_Human1.49963503
70P300_18555785_Chip-Seq_ESCs_Mouse1.49443098
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48327138
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.47918977
73RUNX1_27457419_Chip-Seq_LIVER_Mouse1.46906634
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46505405
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.43157501
76E2F7_22180533_ChIP-Seq_HELA_Human1.42837508
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.41980286
78DROSHA_22980978_ChIP-Seq_HELA_Human1.40983290
79IRF1_19129219_ChIP-ChIP_H3396_Human1.40783931
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40611165
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40581404
82CBP_20019798_ChIP-Seq_JUKART_Human1.40581404
83REST_21632747_ChIP-Seq_MESCs_Mouse1.39574830
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38177085
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37582066
86ER_23166858_ChIP-Seq_MCF-7_Human1.37070580
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36810704
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36208852
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35587977
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34094598
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.33641164
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33578108
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32912616
94PU1_27457419_Chip-Seq_LIVER_Mouse1.32427881
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.31542734
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31530549
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30309353
98MYC_18940864_ChIP-ChIP_HL60_Human1.30108629
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30106536
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29231683
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29231683
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28630267
103ZFX_18555785_Chip-Seq_ESCs_Mouse1.28410176
104KLF4_18555785_Chip-Seq_ESCs_Mouse1.28243651
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27294688
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27107156
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.25904485
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25142152
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25093876
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24873378
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.24638842
112SMAD1_18555785_Chip-Seq_ESCs_Mouse1.23611142
113OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23362122
114* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.22259859
115STAT3_23295773_ChIP-Seq_U87_Human1.21957850
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21905819
117KDM2B_26808549_Chip-Seq_REH_Human1.21353011
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19224269
119AR_25329375_ChIP-Seq_VCAP_Human1.16186222
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15316388
121RUNX2_22187159_ChIP-Seq_PCA_Human1.14459927
122FOXM1_23109430_ChIP-Seq_U2OS_Human1.13561864
123SOX2_16153702_ChIP-ChIP_HESCs_Human1.13364739
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13022598
125EWS_26573619_Chip-Seq_HEK293_Human1.12966408
126TP53_18474530_ChIP-ChIP_U2OS_Human1.12605587
127AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12233834
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11566322
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10931675
130FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10771225
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10737745
132TCF4_23295773_ChIP-Seq_U87_Human1.10627766
133TCF4_22108803_ChIP-Seq_LS180_Human1.10081173
134JUN_21703547_ChIP-Seq_K562_Human1.09713992
135P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09652370
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09327392
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08237582
138GATA1_26923725_Chip-Seq_HPCs_Mouse1.06053728
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03943120
140CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03840608
141SOX9_26525672_Chip-Seq_HEART_Mouse1.01318163
142WT1_19549856_ChIP-ChIP_CCG9911_Human1.00221107
143RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98525615
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96706408
145POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96568083
146NANOG_19829295_ChIP-Seq_ESCs_Human0.96510888
147SOX2_19829295_ChIP-Seq_ESCs_Human0.96510888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.14619094
2MP0003880_abnormal_central_pattern3.57405927
3MP0003136_yellow_coat_color3.21977820
4MP0002102_abnormal_ear_morphology3.20532583
5MP0006292_abnormal_olfactory_placode3.19224307
6MP0008789_abnormal_olfactory_epithelium2.70372842
7MP0005645_abnormal_hypothalamus_physiol2.69540385
8MP0000566_synostosis2.69532484
9MP0001486_abnormal_startle_reflex2.50858727
10MP0002234_abnormal_pharynx_morphology2.49562646
11MP0002277_abnormal_respiratory_mucosa2.35441198
12MP0009745_abnormal_behavioral_response2.21541119
13MP0004145_abnormal_muscle_electrophysio2.21314063
14MP0004133_heterotaxia2.19889247
15MP0009046_muscle_twitch2.16740833
16MP0004742_abnormal_vestibular_system2.16537288
17MP0005248_abnormal_Harderian_gland2.16398083
18MP0006276_abnormal_autonomic_nervous2.12535935
19MP0005171_absent_coat_pigmentation2.11526180
20MP0002736_abnormal_nociception_after2.09675958
21MP0004381_abnormal_hair_follicle2.07526096
22MP0002735_abnormal_chemical_nociception2.07371372
23MP0001293_anophthalmia2.06853876
24MP0001968_abnormal_touch/_nociception2.06386834
25MP0005394_taste/olfaction_phenotype2.06169702
26MP0005499_abnormal_olfactory_system2.06169702
27MP0010030_abnormal_orbit_morphology2.02711736
28MP0003635_abnormal_synaptic_transmissio1.95892503
29MP0002572_abnormal_emotion/affect_behav1.94096845
30MP0003787_abnormal_imprinting1.89728179
31MP0002282_abnormal_trachea_morphology1.83458099
32MP0005409_darkened_coat_color1.82907627
33MP0003122_maternal_imprinting1.81931854
34MP0002653_abnormal_ependyma_morphology1.81917497
35MP0008058_abnormal_DNA_repair1.80993568
36MP0001440_abnormal_grooming_behavior1.80931580
37MP0001501_abnormal_sleep_pattern1.79178695
38MP0002272_abnormal_nervous_system1.78775263
39MP0005646_abnormal_pituitary_gland1.77371888
40MP0002233_abnormal_nose_morphology1.77351045
41MP0004142_abnormal_muscle_tone1.74504868
42MP0001529_abnormal_vocalization1.74324162
43MP0002067_abnormal_sensory_capabilities1.73258905
44MP0003937_abnormal_limbs/digits/tail_de1.72550630
45MP0002064_seizures1.72202575
46MP0010094_abnormal_chromosome_stability1.71237759
47MP0002938_white_spotting1.68932126
48MP0000751_myopathy1.68892367
49MP0000026_abnormal_inner_ear1.66499284
50MP0002063_abnormal_learning/memory/cond1.63943768
51MP0003646_muscle_fatigue1.59144905
52MP0003011_delayed_dark_adaptation1.59070087
53MP0004859_abnormal_synaptic_plasticity1.58561227
54MP0001986_abnormal_taste_sensitivity1.57218108
55MP0005423_abnormal_somatic_nervous1.56585258
56MP0000015_abnormal_ear_pigmentation1.56422414
57MP0003938_abnormal_ear_development1.52637956
58MP0002734_abnormal_mechanical_nocicepti1.50198278
59MP0004270_analgesia1.49007502
60MP0001963_abnormal_hearing_physiology1.48985086
61MP0003119_abnormal_digestive_system1.48060286
62MP0000778_abnormal_nervous_system1.47046469
63MP0001299_abnormal_eye_distance/1.46092549
64MP0001286_abnormal_eye_development1.45878504
65MP0002697_abnormal_eye_size1.45032381
66MP0001905_abnormal_dopamine_level1.44447207
67MP0010386_abnormal_urinary_bladder1.43859108
68MP0003755_abnormal_palate_morphology1.40895921
69MP0000749_muscle_degeneration1.40108917
70MP0002184_abnormal_innervation1.39780163
71MP0002876_abnormal_thyroid_physiology1.39429531
72MP0002557_abnormal_social/conspecific_i1.37872071
73MP0005379_endocrine/exocrine_gland_phen1.36767106
74MP0003121_genomic_imprinting1.35116220
75MP0000383_abnormal_hair_follicle1.34989797
76MP0005391_vision/eye_phenotype1.30679631
77MP0005551_abnormal_eye_electrophysiolog1.26846580
78MP0003890_abnormal_embryonic-extraembry1.25980314
79MP0008932_abnormal_embryonic_tissue1.25538024
80MP0003283_abnormal_digestive_organ1.24049877
81MP0001984_abnormal_olfaction1.23902290
82MP0005174_abnormal_tail_pigmentation1.23364334
83MP0005451_abnormal_body_composition1.22665942
84MP0002090_abnormal_vision1.22398741
85MP0000516_abnormal_urinary_system1.22128181
86MP0005367_renal/urinary_system_phenotyp1.22128181
87MP0008260_abnormal_autophagy1.21149542
88MP0003698_abnormal_male_reproductive1.17954028
89MP0000537_abnormal_urethra_morphology1.17905603
90MP0001324_abnormal_eye_pigmentation1.17167874
91MP0002638_abnormal_pupillary_reflex1.15672619
92MP0008995_early_reproductive_senescence1.13389009
93MP0001970_abnormal_pain_threshold1.10689347
94MP0003942_abnormal_urinary_system1.08428429
95MP0005410_abnormal_fertilization1.08053235
96MP0009697_abnormal_copulation1.07418493
97MP0001929_abnormal_gametogenesis1.07341975
98MP0000631_abnormal_neuroendocrine_gland1.06882320
99MP0001502_abnormal_circadian_rhythm1.06607298
100MP0002163_abnormal_gland_morphology1.05943889
101MP0003935_abnormal_craniofacial_develop1.05315955
102MP0005408_hypopigmentation1.04423802
103MP0000049_abnormal_middle_ear1.04272440
104MP0002752_abnormal_somatic_nervous1.04102422
105MP0003567_abnormal_fetal_cardiomyocyte1.03337541
106MP0002092_abnormal_eye_morphology1.01860596
107MP0002733_abnormal_thermal_nociception1.01362142
108MP0003861_abnormal_nervous_system1.00937582
109MP0000372_irregular_coat_pigmentation0.96739054
110MP0004957_abnormal_blastocyst_morpholog0.95186436
111MP0005257_abnormal_intraocular_pressure0.94222448
112MP0003137_abnormal_impulse_conducting0.94184558
113MP0003315_abnormal_perineum_morphology0.93699510
114MP0001346_abnormal_lacrimal_gland0.93000386
115MP0001485_abnormal_pinna_reflex0.92736508
116MP0003077_abnormal_cell_cycle0.92341894
117MP0002210_abnormal_sex_determination0.91827972
118MP0000955_abnormal_spinal_cord0.91319800
119MP0003879_abnormal_hair_cell0.91033395
120MP0005195_abnormal_posterior_eye0.90611457
121MP0002111_abnormal_tail_morphology0.90515731
122MP0000569_abnormal_digit_pigmentation0.90316707
123MP0002837_dystrophic_cardiac_calcinosis0.90150645
124MP0003724_increased_susceptibility_to0.89961702
125MP0009379_abnormal_foot_pigmentation0.89660045
126MP0006072_abnormal_retinal_apoptosis0.89596944
127MP0005187_abnormal_penis_morphology0.89249382
128MP0000534_abnormal_ureter_morphology0.89190526
129MP0009053_abnormal_anal_canal0.87303956
130MP0001664_abnormal_digestion0.86990827
131MP0002066_abnormal_motor_capabilities/c0.86030649
132MP0002882_abnormal_neuron_morphology0.85698143
133MP0000647_abnormal_sebaceous_gland0.85026297
134MP0003941_abnormal_skin_development0.84915874
135MP0010678_abnormal_skin_adnexa0.84489961
136MP0004197_abnormal_fetal_growth/weight/0.83483667
137MP0002822_catalepsy0.83432445
138MP0001145_abnormal_male_reproductive0.82905692
139MP0003385_abnormal_body_wall0.82199009
140MP0000462_abnormal_digestive_system0.82137353
141MP0004924_abnormal_behavior0.82051826
142MP0005386_behavior/neurological_phenoty0.82051826
143MP0005253_abnormal_eye_physiology0.81695930
144MP0004484_altered_response_of0.81469328
145MP0000579_abnormal_nail_morphology0.80718980
146MP0005377_hearing/vestibular/ear_phenot0.78917728
147MP0003878_abnormal_ear_physiology0.78917728
148MP0003693_abnormal_embryo_hatching0.78659973
149MP0002084_abnormal_developmental_patter0.78419288
150MP0002152_abnormal_brain_morphology0.77762326
151MP0005075_abnormal_melanosome_morpholog0.76141959
152MP0002751_abnormal_autonomic_nervous0.75729402
153MP0000653_abnormal_sex_gland0.75565514
154MP0008004_abnormal_stomach_pH0.75023112
155MP0002095_abnormal_skin_pigmentation0.73325957
156MP0002249_abnormal_larynx_morphology0.70321474
157MP0001727_abnormal_embryo_implantation0.69059140
158MP0008569_lethality_at_weaning0.66614685
159MP0000762_abnormal_tongue_morphology0.64690741
160MP0009250_abnormal_appendicular_skeleto0.64189440
161MP0002106_abnormal_muscle_physiology0.63757281
162MP0005369_muscle_phenotype0.63729564
163MP0002177_abnormal_outer_ear0.63512076
164MP0000681_abnormal_thyroid_gland0.62592455

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.79393804
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.04011987
3Febrile seizures (HP:0002373)4.64453506
4True hermaphroditism (HP:0010459)4.16489436
5Chromsome breakage (HP:0040012)4.12086927
6Pancreatic fibrosis (HP:0100732)3.92579067
7Absent/shortened dynein arms (HP:0200106)3.67125852
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.67125852
9Pancreatic cysts (HP:0001737)3.52292499
10Duplicated collecting system (HP:0000081)3.51999551
11Abnormal ciliary motility (HP:0012262)3.44362084
12Hyperglycinemia (HP:0002154)3.43788196
13Chronic hepatic failure (HP:0100626)3.43518620
14Intestinal atresia (HP:0011100)3.38477775
15Septo-optic dysplasia (HP:0100842)3.29370852
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.25735220
17Molar tooth sign on MRI (HP:0002419)3.24074664
18Abnormality of midbrain morphology (HP:0002418)3.24074664
19Rhinitis (HP:0012384)3.18540873
20Abnormality of the renal collecting system (HP:0004742)3.17709183
21Occipital encephalocele (HP:0002085)3.05944888
22Muscle fiber inclusion bodies (HP:0100299)3.04059996
23Upper limb muscle weakness (HP:0003484)3.02853630
24Anencephaly (HP:0002323)3.00200495
25Muscle hypertrophy of the lower extremities (HP:0008968)2.92537488
26Congenital primary aphakia (HP:0007707)2.91740375
27Nemaline bodies (HP:0003798)2.88315592
28Oligodactyly (hands) (HP:0001180)2.84753755
29Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.81934657
30Abnormal respiratory motile cilium morphology (HP:0005938)2.80778462
31Abnormal respiratory epithelium morphology (HP:0012253)2.80778462
32Atonic seizures (HP:0010819)2.80568359
33Broad-based gait (HP:0002136)2.78295030
34Hypothermia (HP:0002045)2.77910194
35Hyperventilation (HP:0002883)2.74333822
36Nonprogressive disorder (HP:0003680)2.72775227
37Anophthalmia (HP:0000528)2.72417433
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.71526886
39Postaxial foot polydactyly (HP:0001830)2.69713847
40Preaxial hand polydactyly (HP:0001177)2.69648463
41Abnormal respiratory motile cilium physiology (HP:0012261)2.67925038
42Congenital stationary night blindness (HP:0007642)2.62267362
43Abnormality of the labia minora (HP:0012880)2.61629548
44Cystic liver disease (HP:0006706)2.60717997
45Congenital sensorineural hearing impairment (HP:0008527)2.59578844
46Obstructive lung disease (HP:0006536)2.58535448
47Chronic obstructive pulmonary disease (HP:0006510)2.58535448
48Nephrogenic diabetes insipidus (HP:0009806)2.58007517
49Genital tract atresia (HP:0001827)2.57899688
50Calf muscle hypertrophy (HP:0008981)2.57770018
51Fetal akinesia sequence (HP:0001989)2.56906271
52Prostate neoplasm (HP:0100787)2.56680007
53Vaginal atresia (HP:0000148)2.52805344
54Decreased central vision (HP:0007663)2.51895482
55Hyperglycinuria (HP:0003108)2.51034578
56Epileptic encephalopathy (HP:0200134)2.50465709
57Focal seizures (HP:0007359)2.49978189
58Abnormality of the renal medulla (HP:0100957)2.49775424
59Optic nerve hypoplasia (HP:0000609)2.49516822
60Aplasia cutis congenita (HP:0001057)2.48751191
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44368372
62Sclerocornea (HP:0000647)2.44178959
63Abnormality of serine family amino acid metabolism (HP:0010894)2.42150016
64Abnormality of glycine metabolism (HP:0010895)2.42150016
65Protruding tongue (HP:0010808)2.42058881
66Postaxial hand polydactyly (HP:0001162)2.41150896
67Exercise-induced muscle cramps (HP:0003710)2.38871720
68Exercise-induced myalgia (HP:0003738)2.38052777
69Colon cancer (HP:0003003)2.34915573
70Abnormality of the parathyroid morphology (HP:0011766)2.34347909
71Fair hair (HP:0002286)2.32233957
72Bifid tongue (HP:0010297)2.31242340
73Tubular atrophy (HP:0000092)2.28892988
74Specific learning disability (HP:0001328)2.24101671
75Abnormality of DNA repair (HP:0003254)2.23914972
76Gastrointestinal atresia (HP:0002589)2.23392095
77Congenital hepatic fibrosis (HP:0002612)2.23174778
78Poor coordination (HP:0002370)2.22957562
79Oligodactyly (HP:0012165)2.21851800
80Hemiparesis (HP:0001269)2.21480032
81Hypophosphatemic rickets (HP:0004912)2.20725551
82Tubulointerstitial nephritis (HP:0001970)2.19480145
83Volvulus (HP:0002580)2.16465229
84Atelectasis (HP:0100750)2.12262674
85Esophageal atresia (HP:0002032)2.12150839
86Generalized tonic-clonic seizures (HP:0002069)2.11605179
87Medial flaring of the eyebrow (HP:0010747)2.11391448
88Aqueductal stenosis (HP:0002410)2.09625162
89Impulsivity (HP:0100710)2.09012046
90Absent septum pellucidum (HP:0001331)2.07402495
91Abnormal biliary tract physiology (HP:0012439)2.06336835
92Bile duct proliferation (HP:0001408)2.06336835
93Patchy hypopigmentation of hair (HP:0011365)2.05917455
94Attenuation of retinal blood vessels (HP:0007843)2.05093416
95Oculomotor apraxia (HP:0000657)2.03760589
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02259082
97Broad foot (HP:0001769)2.02201555
98Absent speech (HP:0001344)1.99420913
99Gaze-evoked nystagmus (HP:0000640)1.98871937
100Supernumerary spleens (HP:0009799)1.97392560
101Abnormal hair whorl (HP:0010721)1.96941234
102Abnormality of the ileum (HP:0001549)1.95860321
103White forelock (HP:0002211)1.95698599
104Abnormality of alanine metabolism (HP:0010916)1.95592935
105Hyperalaninemia (HP:0003348)1.95592935
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95592935
107Aganglionic megacolon (HP:0002251)1.93736711
108Meckel diverticulum (HP:0002245)1.92995277
109Keratoconus (HP:0000563)1.92990391
110Increased corneal curvature (HP:0100692)1.92990391
111Optic disc pallor (HP:0000543)1.92656372
112Dialeptic seizures (HP:0011146)1.92432556
113Exotropia (HP:0000577)1.91064221
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.90715539
115Median cleft lip (HP:0000161)1.89773087
116Chronic bronchitis (HP:0004469)1.89314858
117Distal lower limb amyotrophy (HP:0008944)1.88729823
118Duplication of thumb phalanx (HP:0009942)1.88225000
119Tubulointerstitial abnormality (HP:0001969)1.87336481
120Nephronophthisis (HP:0000090)1.87235608
121Abnormality of the fovea (HP:0000493)1.85981681
122Bronchiectasis (HP:0002110)1.85861284
123Aplasia/Hypoplasia of the fovea (HP:0008060)1.85016760
124Hypoplasia of the fovea (HP:0007750)1.85016760
125Esotropia (HP:0000565)1.84721542
126Generalized hypopigmentation of hair (HP:0011358)1.84570233
127Cortical dysplasia (HP:0002539)1.83727732
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.83677852
129Short tibia (HP:0005736)1.83560935
130Morphological abnormality of the middle ear (HP:0008609)1.83491911
131Dandy-Walker malformation (HP:0001305)1.83321759
132Progressive cerebellar ataxia (HP:0002073)1.81664407
133Absence seizures (HP:0002121)1.81344741
134Mesomelia (HP:0003027)1.81155785
135Narrow forehead (HP:0000341)1.79259054
136Conical tooth (HP:0000698)1.79212798
137Abnormality of the septum pellucidum (HP:0007375)1.79046798
138Triphalangeal thumb (HP:0001199)1.77425666
139Abnormality of serum amino acid levels (HP:0003112)1.76691843
140Nasolacrimal duct obstruction (HP:0000579)1.76258482
141Osteomalacia (HP:0002749)1.75665313
142Renal hypoplasia (HP:0000089)1.75587202
143Aplasia/Hypoplasia of the lens (HP:0008063)1.75426503
144Aplasia of the musculature (HP:0100854)1.74729881
145Abnormality of the calf musculature (HP:0001430)1.74318556
146Holoprosencephaly (HP:0001360)1.73818416
147Vitreoretinal degeneration (HP:0000655)1.73553895
148Hyperthyroidism (HP:0000836)1.73478585
149Growth hormone deficiency (HP:0000824)1.73185601
150Abolished electroretinogram (ERG) (HP:0000550)1.73042940
151Symphalangism affecting the phalanges of the hand (HP:0009773)1.72552983
152Aplasia/Hypoplasia of the sternum (HP:0006714)1.72294121
153Overfolded helix (HP:0000396)1.72263752
154Astigmatism (HP:0000483)1.72091575
155Corneal dystrophy (HP:0001131)1.71386894
156Distal lower limb muscle weakness (HP:0009053)1.70664423
157Abnormality of the astrocytes (HP:0100707)1.70594737
158Astrocytoma (HP:0009592)1.70594737
159Hyperkalemia (HP:0002153)1.70527889
160Sloping forehead (HP:0000340)1.70416775
161Blue irides (HP:0000635)1.70254558
162Gait imbalance (HP:0002141)1.70138304
163Chorioretinal coloboma (HP:0000567)1.69682813
164Labial hypoplasia (HP:0000066)1.69137654
165Anomalous pulmonary venous return (HP:0010772)1.68920547
166Thyroid-stimulating hormone excess (HP:0002925)1.68856399
167Abnormality of the duodenum (HP:0002246)1.68849075
168Dyskinesia (HP:0100660)1.68748152
169Split foot (HP:0001839)1.68666945
170Abnormal rod and cone electroretinograms (HP:0008323)1.68525259
171Stenosis of the external auditory canal (HP:0000402)1.67874251
172Optic neuritis (HP:0100653)1.66802219
173Retrobulbar optic neuritis (HP:0100654)1.66802219
174Male pseudohermaphroditism (HP:0000037)1.66701009
175Abnormality of the dental pulp (HP:0006479)1.66652581
176Abnormality of the lacrimal duct (HP:0011481)1.66398008
177Abnormality of the renal cortex (HP:0011035)1.66392721
178Prominent nasal bridge (HP:0000426)1.65133600
179Abnormality of secondary sexual hair (HP:0009888)1.64699300
180Abnormality of the axillary hair (HP:0100134)1.64699300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.63209577
2MAP4K23.00126562
3WEE12.91176932
4MAP2K72.67707621
5NTRK32.52672514
6PLK42.41065361
7FGR2.39706079
8TNIK2.30819704
9SIK32.29753342
10PRKD32.28882586
11TRIM282.26197535
12EIF2AK22.17860117
13OBSCN2.15379844
14STK162.08271138
15SIK22.01118547
16BRSK21.91633963
17ADRBK21.91532634
18MAPK131.91059407
19GRK11.90009115
20NEK11.83984877
21TXK1.83830208
22BLK1.82885859
23GRK71.75618532
24EPHA41.75052131
25INSRR1.73748686
26CDC71.68375410
27RIPK41.63800932
28ERBB31.62819681
29PLK31.61317272
30NME11.59564137
31MAP3K41.59557791
32SRPK11.54115106
33PRPF4B1.54001530
34YES11.52831403
35TNK21.52081527
36VRK11.46807418
37AKT31.41068636
38TAOK21.39091083
39TSSK61.37278032
40OXSR11.36312016
41PKN11.35005690
42MAP3K131.34618002
43CSNK1G11.34013018
44MUSK1.31878283
45BMPR21.31575914
46TGFBR11.30003387
47CSNK1G31.29197726
48CSNK1G21.20395825
49EPHA31.18684573
50MKNK21.18337893
51FRK1.15498815
52MAP2K61.14498032
53TTK1.12530425
54CSNK1A1L1.11155430
55PHKG21.10152319
56PHKG11.10152319
57TLK11.10099043
58DYRK31.09891886
59PLK21.09641830
60EIF2AK31.09175304
61IRAK31.07515092
62BMPR1B1.04592767
63MARK11.04510383
64MST41.03894232
65IRAK21.03332774
66MAP3K141.03165651
67STK391.02184806
68PRKCE1.00729421
69MAP2K41.00167985
70IRAK40.98120326
71RPS6KA40.97467167
72PBK0.96815997
73FES0.96091410
74BRSK10.95620621
75PLK10.95421382
76ACVR1B0.93871931
77SGK20.93624397
78NTRK20.88539790
79PIK3CG0.87747518
80TEC0.86689565
81PINK10.85028618
82MAP3K120.84817692
83BRD40.84359460
84CAMK2A0.82881146
85VRK20.79728482
86NEK60.79298497
87TIE10.79014460
88BCR0.79008917
89FGFR20.77707555
90LATS10.77411126
91PRKCQ0.77380446
92IRAK10.76638115
93PIK3CA0.74994647
94NUAK10.73419401
95CDK190.73394054
96CDK30.72582156
97CDK70.71441119
98CAMK2B0.69191260
99NEK90.69012400
100MAPK120.68507593
101UHMK10.65225871
102DMPK0.64527191
103STK38L0.63317403
104ADRBK10.61756730
105SGK4940.60856044
106SGK2230.60856044
107EPHB20.60579244
108BCKDK0.58862980
109BUB10.57689686
110SGK10.57178487
111ATR0.55826797
112DYRK20.55653549
113GRK50.53908051
114PRKG10.52472263
115FER0.51899349
116PASK0.50754737
117KSR10.50725743
118CHEK20.49587537
119LYN0.49342162
120PRKCG0.49084963
121FGFR10.48925886
122ERBB20.48179527
123CSK0.47412081
124ERBB40.47062806
125MINK10.46867423
126PRKACA0.46437658
127WNK30.45257823
128CDK50.45256635
129PNCK0.44642145
130MKNK10.44116608
131ATM0.43621004
132AURKB0.43556478
133CAMK2G0.42602738
134STK240.42219565
135ROCK20.41639405
136CSNK1A10.41556196
137ZAK0.38567370
138MAPK150.38111237
139CSNK2A10.34648814
140TRPM70.34436037
141EIF2AK10.34076414
142DYRK1B0.33837350
143CDK90.33527040
144NLK0.33298336
145STK380.33038857
146SGK30.32610864
147PRKAA20.31863702
148MARK20.31439494
149CAMK2D0.30984607
150BRAF0.30954403
151WNK10.30812797
152MAP3K60.30551501
153MAPK70.29906946
154CDK80.29838465
155FYN0.29170842
156DYRK1A0.27235094
157STK30.25979882

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.72600633
2Protein export_Homo sapiens_hsa030603.23838241
3Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.81517720
4Phototransduction_Homo sapiens_hsa047442.79103184
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.64324508
6Morphine addiction_Homo sapiens_hsa050322.49249410
7Taste transduction_Homo sapiens_hsa047422.47228848
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39766552
9Propanoate metabolism_Homo sapiens_hsa006402.39551512
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31765311
11Serotonergic synapse_Homo sapiens_hsa047262.20719454
12Mismatch repair_Homo sapiens_hsa034302.12663553
13Butanoate metabolism_Homo sapiens_hsa006502.06336779
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03037281
15Glutamatergic synapse_Homo sapiens_hsa047241.99310563
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.99030441
17Calcium signaling pathway_Homo sapiens_hsa040201.91175151
18Oxidative phosphorylation_Homo sapiens_hsa001901.86447202
19Basal transcription factors_Homo sapiens_hsa030221.84116959
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82910744
21Non-homologous end-joining_Homo sapiens_hsa034501.82343289
22Collecting duct acid secretion_Homo sapiens_hsa049661.68469505
23GABAergic synapse_Homo sapiens_hsa047271.64992223
24Fanconi anemia pathway_Homo sapiens_hsa034601.62108733
25Olfactory transduction_Homo sapiens_hsa047401.60846646
26Spliceosome_Homo sapiens_hsa030401.53935396
27RNA transport_Homo sapiens_hsa030131.52586967
28Nucleotide excision repair_Homo sapiens_hsa034201.52334563
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52214876
30Basal cell carcinoma_Homo sapiens_hsa052171.51104079
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50141371
32Circadian entrainment_Homo sapiens_hsa047131.46313239
33Ether lipid metabolism_Homo sapiens_hsa005651.45585438
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43988017
35Axon guidance_Homo sapiens_hsa043601.42841511
36RNA degradation_Homo sapiens_hsa030181.39904403
37Salivary secretion_Homo sapiens_hsa049701.39318000
38Amphetamine addiction_Homo sapiens_hsa050311.39080799
39DNA replication_Homo sapiens_hsa030301.39029955
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38502657
41Sphingolipid metabolism_Homo sapiens_hsa006001.36856816
42Long-term depression_Homo sapiens_hsa047301.36257604
43One carbon pool by folate_Homo sapiens_hsa006701.35912140
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.35496653
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.31313389
46Cell cycle_Homo sapiens_hsa041101.28798166
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26732379
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25481712
49Renin secretion_Homo sapiens_hsa049241.25119700
50Base excision repair_Homo sapiens_hsa034101.24579643
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23528025
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22404430
53Folate biosynthesis_Homo sapiens_hsa007901.20424207
54Dopaminergic synapse_Homo sapiens_hsa047281.19654283
55Peroxisome_Homo sapiens_hsa041461.18456228
56Rheumatoid arthritis_Homo sapiens_hsa053231.18380803
57Alzheimers disease_Homo sapiens_hsa050101.17308399
58RNA polymerase_Homo sapiens_hsa030201.16965548
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15400907
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14743022
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11535468
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10806920
63Autoimmune thyroid disease_Homo sapiens_hsa053201.08861935
64Sulfur relay system_Homo sapiens_hsa041221.08669026
65Ovarian steroidogenesis_Homo sapiens_hsa049131.08514177
66Oxytocin signaling pathway_Homo sapiens_hsa049211.07393334
67Cardiac muscle contraction_Homo sapiens_hsa042601.05176240
68Fatty acid metabolism_Homo sapiens_hsa012121.04700776
69Synaptic vesicle cycle_Homo sapiens_hsa047211.03417490
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02906256
71Parkinsons disease_Homo sapiens_hsa050121.01822741
72TGF-beta signaling pathway_Homo sapiens_hsa043501.01372491
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01367945
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01186858
75Cocaine addiction_Homo sapiens_hsa050301.01127540
76Cholinergic synapse_Homo sapiens_hsa047250.99419946
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99034211
78Hippo signaling pathway_Homo sapiens_hsa043900.97782909
79Proteasome_Homo sapiens_hsa030500.97338073
80Insulin secretion_Homo sapiens_hsa049110.97295713
81Biosynthesis of amino acids_Homo sapiens_hsa012300.96225126
82Arachidonic acid metabolism_Homo sapiens_hsa005900.94568674
83Linoleic acid metabolism_Homo sapiens_hsa005910.93874107
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.93053428
85Carbon metabolism_Homo sapiens_hsa012000.91528177
86Gastric acid secretion_Homo sapiens_hsa049710.91328230
87Oocyte meiosis_Homo sapiens_hsa041140.91009167
88mRNA surveillance pathway_Homo sapiens_hsa030150.90312730
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90122189
90Hedgehog signaling pathway_Homo sapiens_hsa043400.90098255
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90025791
92Pyruvate metabolism_Homo sapiens_hsa006200.89575931
93Selenocompound metabolism_Homo sapiens_hsa004500.86447026
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85638902
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85424355
96Huntingtons disease_Homo sapiens_hsa050160.84737316
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84512596
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84461609
99Asthma_Homo sapiens_hsa053100.81657969
100Circadian rhythm_Homo sapiens_hsa047100.81486609
101cAMP signaling pathway_Homo sapiens_hsa040240.81213034
102GnRH signaling pathway_Homo sapiens_hsa049120.80485179
103Hematopoietic cell lineage_Homo sapiens_hsa046400.79678109
104Fatty acid biosynthesis_Homo sapiens_hsa000610.78052639
105Fatty acid elongation_Homo sapiens_hsa000620.78032546
106Graft-versus-host disease_Homo sapiens_hsa053320.77703540
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77523132
108p53 signaling pathway_Homo sapiens_hsa041150.76775781
109Dilated cardiomyopathy_Homo sapiens_hsa054140.76394076
110Nitrogen metabolism_Homo sapiens_hsa009100.76114463
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75472020
112Phagosome_Homo sapiens_hsa041450.74015161
113Long-term potentiation_Homo sapiens_hsa047200.73994665
114Pyrimidine metabolism_Homo sapiens_hsa002400.73175740
115Vitamin digestion and absorption_Homo sapiens_hsa049770.72807744
116Purine metabolism_Homo sapiens_hsa002300.71412106
117African trypanosomiasis_Homo sapiens_hsa051430.69040680
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.68681768
119Fatty acid degradation_Homo sapiens_hsa000710.67879563
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.67765258
121Pancreatic secretion_Homo sapiens_hsa049720.66960471
122Vibrio cholerae infection_Homo sapiens_hsa051100.65871400
123Glutathione metabolism_Homo sapiens_hsa004800.65575692
124Staphylococcus aureus infection_Homo sapiens_hsa051500.65569309
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65452800
126Metabolic pathways_Homo sapiens_hsa011000.65152117
127Homologous recombination_Homo sapiens_hsa034400.65013421
128MAPK signaling pathway_Homo sapiens_hsa040100.64427910
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64370686
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.63958122
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63454725
132Ras signaling pathway_Homo sapiens_hsa040140.61068064
133Ribosome_Homo sapiens_hsa030100.61052780
134Type I diabetes mellitus_Homo sapiens_hsa049400.59036688
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58862679
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58315465
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.58219144
138ErbB signaling pathway_Homo sapiens_hsa040120.57447723
139Arginine and proline metabolism_Homo sapiens_hsa003300.56479519
140Vitamin B6 metabolism_Homo sapiens_hsa007500.55309523
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54023172
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53893812
143Melanogenesis_Homo sapiens_hsa049160.52437000
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52095230
145Allograft rejection_Homo sapiens_hsa053300.51446933
146beta-Alanine metabolism_Homo sapiens_hsa004100.51317660
147Chemical carcinogenesis_Homo sapiens_hsa052040.51017905
148Caffeine metabolism_Homo sapiens_hsa002320.50708605
149Alcoholism_Homo sapiens_hsa050340.50598850
150Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46741833
151Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46458083
152Chemokine signaling pathway_Homo sapiens_hsa040620.45151714
153ABC transporters_Homo sapiens_hsa020100.43989198
154Regulation of autophagy_Homo sapiens_hsa041400.43653591
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.43486458
156Wnt signaling pathway_Homo sapiens_hsa043100.43313757
157Tryptophan metabolism_Homo sapiens_hsa003800.43095741
158Choline metabolism in cancer_Homo sapiens_hsa052310.41763749
159Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40356351
160Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39785268
161Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38589716
162Rap1 signaling pathway_Homo sapiens_hsa040150.37332816
163Sulfur metabolism_Homo sapiens_hsa009200.36892515
164Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36845734
165Primary immunodeficiency_Homo sapiens_hsa053400.36428753
166Steroid biosynthesis_Homo sapiens_hsa001000.36228540
167Retinol metabolism_Homo sapiens_hsa008300.35502004

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