TIAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.68136213
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.10838409
3fucose catabolic process (GO:0019317)3.92189686
4L-fucose metabolic process (GO:0042354)3.92189686
5L-fucose catabolic process (GO:0042355)3.92189686
6response to pheromone (GO:0019236)3.86387016
7indole-containing compound catabolic process (GO:0042436)3.82334957
8indolalkylamine catabolic process (GO:0046218)3.82334957
9tryptophan catabolic process (GO:0006569)3.82334957
10kynurenine metabolic process (GO:0070189)3.60831631
11proline transport (GO:0015824)3.56127795
12tryptophan metabolic process (GO:0006568)3.52046193
13indolalkylamine metabolic process (GO:0006586)3.39560904
14platelet dense granule organization (GO:0060155)3.32779333
15negative regulation of cytosolic calcium ion concentration (GO:0051481)3.32227692
16gamma-aminobutyric acid transport (GO:0015812)3.27597732
17cellular ketone body metabolic process (GO:0046950)3.23230684
18neuronal action potential propagation (GO:0019227)3.06034463
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02246984
20DNA deamination (GO:0045006)3.01538926
21oxidative demethylation (GO:0070989)2.97918391
22amine catabolic process (GO:0009310)2.95688253
23cellular biogenic amine catabolic process (GO:0042402)2.95688253
24ketone body metabolic process (GO:1902224)2.93228457
25inositol phosphate catabolic process (GO:0071545)2.90209817
26negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90111742
27pyrimidine nucleobase catabolic process (GO:0006208)2.89700695
28preassembly of GPI anchor in ER membrane (GO:0016254)2.86767520
29S-adenosylmethionine metabolic process (GO:0046500)2.84222820
30neural tube formation (GO:0001841)2.83274563
31neuronal action potential (GO:0019228)2.82107458
32indole-containing compound metabolic process (GO:0042430)2.76639595
33membrane depolarization during action potential (GO:0086010)2.75677747
34startle response (GO:0001964)2.75270322
35aromatic amino acid family catabolic process (GO:0009074)2.73248914
36detection of light stimulus involved in visual perception (GO:0050908)2.69731034
37detection of light stimulus involved in sensory perception (GO:0050962)2.69731034
38piRNA metabolic process (GO:0034587)2.69322580
39drug catabolic process (GO:0042737)2.68992772
40inositol phosphate dephosphorylation (GO:0046855)2.68710837
41phosphorylated carbohydrate dephosphorylation (GO:0046838)2.68710837
42synaptic vesicle maturation (GO:0016188)2.66130310
43cellular response to exogenous dsRNA (GO:0071360)2.65751142
44nucleobase catabolic process (GO:0046113)2.65527197
45glycosphingolipid biosynthetic process (GO:0006688)2.65438785
46regulation of action potential (GO:0098900)2.65103498
47DNA methylation involved in gamete generation (GO:0043046)2.65070221
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64903461
49dendritic spine morphogenesis (GO:0060997)2.62568906
50auditory receptor cell stereocilium organization (GO:0060088)2.62071512
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58301973
52neuromuscular synaptic transmission (GO:0007274)2.55717287
53cellular response to ATP (GO:0071318)2.55221571
54C4-dicarboxylate transport (GO:0015740)2.52938522
55axoneme assembly (GO:0035082)2.51772184
56protein import into peroxisome matrix (GO:0016558)2.51004801
57regulation of glucokinase activity (GO:0033131)2.50617640
58regulation of hexokinase activity (GO:1903299)2.50617640
59exogenous drug catabolic process (GO:0042738)2.49930391
60cytochrome complex assembly (GO:0017004)2.49136296
61axon ensheathment in central nervous system (GO:0032291)2.48234056
62central nervous system myelination (GO:0022010)2.48234056
63protein complex biogenesis (GO:0070271)2.42674842
64glycerophospholipid catabolic process (GO:0046475)2.41371445
65alanine transport (GO:0032328)2.40545155
66regulation of calcium ion-dependent exocytosis (GO:0017158)2.40449721
67regulation of nuclear cell cycle DNA replication (GO:0033262)2.39828677
68water-soluble vitamin biosynthetic process (GO:0042364)2.39366605
69positive regulation of fatty acid transport (GO:2000193)2.37887746
70negative regulation of mast cell activation (GO:0033004)2.37572063
71regulation of short-term neuronal synaptic plasticity (GO:0048172)2.37562351
72reflex (GO:0060004)2.34721572
73purinergic nucleotide receptor signaling pathway (GO:0035590)2.33690719
74polyol catabolic process (GO:0046174)2.33317969
75regulation of neurotransmitter uptake (GO:0051580)2.32887200
76action potential (GO:0001508)2.29718372
77spinal cord motor neuron differentiation (GO:0021522)2.28874095
78respiratory chain complex IV assembly (GO:0008535)2.27403109
79sulfation (GO:0051923)2.26791432
80potassium ion transmembrane transport (GO:0071805)2.26424705
81cellular potassium ion transport (GO:0071804)2.26424705
82neurotransmitter metabolic process (GO:0042133)2.26092956
83retinal cone cell development (GO:0046549)2.24843930
84negative regulation of reactive oxygen species metabolic process (GO:2000378)2.24797678
85regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.24752622
86transmission of nerve impulse (GO:0019226)2.24419985
87synaptic transmission, glutamatergic (GO:0035249)2.21352826
88dentate gyrus development (GO:0021542)2.21275217
89positive regulation of sodium ion transmembrane transport (GO:1902307)2.21262892
90potassium ion transport (GO:0006813)2.20200114
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.20030702
92transepithelial transport (GO:0070633)2.19985471
93primary amino compound metabolic process (GO:1901160)2.19777886
94regulation of rhodopsin mediated signaling pathway (GO:0022400)2.18358324
953-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.18184699
96purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.18184699
97presynaptic membrane organization (GO:0097090)2.18033698
98regulation of sarcomere organization (GO:0060297)2.17143535
99neuron-neuron synaptic transmission (GO:0007270)2.16614939
100protein K11-linked deubiquitination (GO:0035871)2.16411493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.59707549
2ZNF274_21170338_ChIP-Seq_K562_Hela3.55495793
3GBX2_23144817_ChIP-Seq_PC3_Human2.94450311
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81384404
5IGF1R_20145208_ChIP-Seq_DFB_Human2.60632424
6VDR_22108803_ChIP-Seq_LS180_Human2.42887220
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23179159
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21446694
9REST_21632747_ChIP-Seq_MESCs_Mouse1.94952965
10POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93750743
11IRF8_22096565_ChIP-ChIP_GC-B_Human1.84917039
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81342567
13CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79592740
14TAF15_26573619_Chip-Seq_HEK293_Human1.74181218
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.73271654
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65916468
17ER_23166858_ChIP-Seq_MCF-7_Human1.64511570
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59544556
19P300_19829295_ChIP-Seq_ESCs_Human1.58781494
20FUS_26573619_Chip-Seq_HEK293_Human1.57094355
21DROSHA_22980978_ChIP-Seq_HELA_Human1.56785581
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53236416
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52985530
24* BCAT_22108803_ChIP-Seq_LS180_Human1.52291011
25ETV2_25802403_ChIP-Seq_MESCs_Mouse1.50729881
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50397394
27TCF4_23295773_ChIP-Seq_U87_Human1.47898772
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.46416727
29CBP_20019798_ChIP-Seq_JUKART_Human1.46388994
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46388994
31TP53_22573176_ChIP-Seq_HFKS_Human1.45378650
32STAT3_23295773_ChIP-Seq_U87_Human1.43404926
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41380773
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37234715
35SMAD4_21799915_ChIP-Seq_A2780_Human1.36425889
36AR_25329375_ChIP-Seq_VCAP_Human1.36319499
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35286534
38EWS_26573619_Chip-Seq_HEK293_Human1.33907945
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32944933
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.28452027
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28242460
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28242460
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26962669
44PRDM14_20953172_ChIP-Seq_ESCs_Human1.25946680
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25897277
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25078865
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24711044
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22563281
49NCOR_22424771_ChIP-Seq_293T_Human1.21791317
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21735007
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21080676
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18405963
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18200557
54AR_21572438_ChIP-Seq_LNCaP_Human1.18032172
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15123485
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.14811241
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14450475
58NANOG_19829295_ChIP-Seq_ESCs_Human1.13541442
59SOX2_19829295_ChIP-Seq_ESCs_Human1.13541442
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12754450
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12503491
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12433577
63* TCF4_22108803_ChIP-Seq_LS180_Human1.09626611
64RUNX2_22187159_ChIP-Seq_PCA_Human1.09501428
65* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09324909
66* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09066506
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08541591
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.07613531
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07316474
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.06190378
71TAF2_19829295_ChIP-Seq_ESCs_Human1.06187344
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05966797
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05956293
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04802903
75IRF1_19129219_ChIP-ChIP_H3396_Human1.04605174
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.04240619
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.04104335
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.03737672
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.02986797
80RNF2_27304074_Chip-Seq_NSC_Mouse1.02208417
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02052718
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01912629
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01897051
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01165371
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.00834653
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00834653
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00115033
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99725390
89SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99428705
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99370191
91ERA_21632823_ChIP-Seq_H3396_Human0.98273528
92MYC_19829295_ChIP-Seq_ESCs_Human0.97748668
93SMAD4_21741376_ChIP-Seq_EPCs_Human0.97725999
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97604273
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.96935730
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96499384
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96350433
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.96246201
99SOX2_21211035_ChIP-Seq_LN229_Gbm0.96183396
100AR_20517297_ChIP-Seq_VCAP_Human0.94063834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.03987217
2MP0003195_calcinosis2.75970673
3MP0008877_abnormal_DNA_methylation2.43311604
4MP0001968_abnormal_touch/_nociception2.42726219
5MP0009745_abnormal_behavioral_response2.29008177
6MP0008875_abnormal_xenobiotic_pharmacok2.28874089
7MP0003880_abnormal_central_pattern2.27394672
8MP0001986_abnormal_taste_sensitivity2.24433715
9MP0002272_abnormal_nervous_system2.20659110
10MP0009046_muscle_twitch2.12448290
11MP0005551_abnormal_eye_electrophysiolog2.10394848
12MP0005645_abnormal_hypothalamus_physiol2.07606338
13MP0008872_abnormal_physiological_respon2.06768117
14MP0002163_abnormal_gland_morphology2.06284811
15MP0002876_abnormal_thyroid_physiology2.05570198
16MP0002064_seizures2.00664957
17MP0002138_abnormal_hepatobiliary_system1.98741827
18MP0003646_muscle_fatigue1.97350792
19MP0005423_abnormal_somatic_nervous1.91140127
20MP0002638_abnormal_pupillary_reflex1.90463418
21MP0004145_abnormal_muscle_electrophysio1.87938645
22MP0001501_abnormal_sleep_pattern1.85945740
23MP0001984_abnormal_olfaction1.82458753
24MP0003635_abnormal_synaptic_transmissio1.82000035
25MP0002837_dystrophic_cardiac_calcinosis1.81704856
26MP0001486_abnormal_startle_reflex1.75971536
27MP0005646_abnormal_pituitary_gland1.64367178
28MP0004859_abnormal_synaptic_plasticity1.59611856
29MP0002572_abnormal_emotion/affect_behav1.55740756
30MP0005379_endocrine/exocrine_gland_phen1.55166265
31MP0004924_abnormal_behavior1.54890964
32MP0005386_behavior/neurological_phenoty1.54890964
33MP0004270_analgesia1.53641626
34MP0004043_abnormal_pH_regulation1.53603512
35MP0002063_abnormal_learning/memory/cond1.53520721
36MP0005174_abnormal_tail_pigmentation1.53520684
37MP0000569_abnormal_digit_pigmentation1.51467384
38MP0003252_abnormal_bile_duct1.49797697
39MP0006276_abnormal_autonomic_nervous1.48038257
40MP0002928_abnormal_bile_duct1.47969125
41MP0001970_abnormal_pain_threshold1.45477613
42MP0004885_abnormal_endolymph1.43029332
43MP0004147_increased_porphyrin_level1.42250501
44MP0002734_abnormal_mechanical_nocicepti1.40967938
45MP0002733_abnormal_thermal_nociception1.37133683
46MP0002735_abnormal_chemical_nociception1.32187900
47MP0010386_abnormal_urinary_bladder1.31252277
48MP0002102_abnormal_ear_morphology1.29465793
49MP0006072_abnormal_retinal_apoptosis1.27556224
50MP0004142_abnormal_muscle_tone1.26587328
51MP0002736_abnormal_nociception_after1.26453533
52MP0005084_abnormal_gallbladder_morpholo1.26143387
53MP0000427_abnormal_hair_cycle1.25898389
54MP0003172_abnormal_lysosome_physiology1.24285873
55MP0002067_abnormal_sensory_capabilities1.20324315
56MP0000015_abnormal_ear_pigmentation1.16809949
57MP0001485_abnormal_pinna_reflex1.16545029
58MP0002557_abnormal_social/conspecific_i1.14887144
59MP0005253_abnormal_eye_physiology1.14709332
60MP0003879_abnormal_hair_cell1.12787674
61MP0001502_abnormal_circadian_rhythm1.08810650
62MP0005075_abnormal_melanosome_morpholog1.06223387
63MP0002229_neurodegeneration1.01272664
64MP0005167_abnormal_blood-brain_barrier1.00737907
65MP0010329_abnormal_lipoprotein_level1.00700451
66MP0004742_abnormal_vestibular_system1.00355002
67MP0001905_abnormal_dopamine_level1.00076321
68MP0002160_abnormal_reproductive_system0.98167561
69MP0005671_abnormal_response_to0.97461117
70MP0003183_abnormal_peptide_metabolism0.94381531
71MP0004130_abnormal_muscle_cell0.93640227
72MP0002653_abnormal_ependyma_morphology0.88992724
73MP0001835_abnormal_antigen_presentation0.87030918
74MP0005220_abnormal_exocrine_pancreas0.86431200
75MP0004215_abnormal_myocardial_fiber0.86314559
76MP0002693_abnormal_pancreas_physiology0.84717176
77MP0005389_reproductive_system_phenotype0.84105377
78MP0006292_abnormal_olfactory_placode0.84058721
79MP0005332_abnormal_amino_acid0.83988814
80MP0001756_abnormal_urination0.83703841
81MP0005365_abnormal_bile_salt0.82677424
82MP0001440_abnormal_grooming_behavior0.81557810
83MP0004133_heterotaxia0.80566331
84MP0000230_abnormal_systemic_arterial0.80283293
85MP0005448_abnormal_energy_balance0.79910791
86MP0003121_genomic_imprinting0.78739871
87MP0004085_abnormal_heartbeat0.77875838
88MP0005410_abnormal_fertilization0.77733384
89MP0000372_irregular_coat_pigmentation0.77498516
90MP0003633_abnormal_nervous_system0.76477616
91MP0001765_abnormal_ion_homeostasis0.76161797
92MP0000631_abnormal_neuroendocrine_gland0.75765555
93MP0002095_abnormal_skin_pigmentation0.74354213
94MP0005535_abnormal_body_temperature0.73036225
95MP0005310_abnormal_salivary_gland0.71366968
96MP0001529_abnormal_vocalization0.71235133
97MP0002066_abnormal_motor_capabilities/c0.71153642
98MP0002882_abnormal_neuron_morphology0.69382799
99MP0002069_abnormal_eating/drinking_beha0.68736708
100MP0008775_abnormal_heart_ventricle0.67369295

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)3.54137407
2Febrile seizures (HP:0002373)3.46409652
3Focal motor seizures (HP:0011153)3.45641131
4Pancreatic cysts (HP:0001737)3.44216198
5Gaze-evoked nystagmus (HP:0000640)3.27418156
6Focal seizures (HP:0007359)3.20570703
7Congenital stationary night blindness (HP:0007642)3.13403058
8Progressive cerebellar ataxia (HP:0002073)3.11204984
9Abnormality of the renal cortex (HP:0011035)3.04180664
10Type II lissencephaly (HP:0007260)3.01296792
11Attenuation of retinal blood vessels (HP:0007843)2.96516826
12Abnormality of midbrain morphology (HP:0002418)2.92500515
13Molar tooth sign on MRI (HP:0002419)2.92500515
14Nephronophthisis (HP:0000090)2.83969790
15Abolished electroretinogram (ERG) (HP:0000550)2.78700491
16Pancreatic fibrosis (HP:0100732)2.76021367
17Polydipsia (HP:0001959)2.74742511
18Abnormal drinking behavior (HP:0030082)2.74742511
19Genetic anticipation (HP:0003743)2.74004346
20True hermaphroditism (HP:0010459)2.62026710
21Decreased circulating renin level (HP:0003351)2.60569938
22Broad-based gait (HP:0002136)2.58122903
23Abnormality of the renal medulla (HP:0100957)2.54766669
24Hemiparesis (HP:0001269)2.54114468
25Dialeptic seizures (HP:0011146)2.53152630
26Progressive inability to walk (HP:0002505)2.52899998
27Protruding tongue (HP:0010808)2.48316890
28Epileptic encephalopathy (HP:0200134)2.46746586
29Inability to walk (HP:0002540)2.46682081
30Ketoacidosis (HP:0001993)2.45799819
31Chronic hepatic failure (HP:0100626)2.42378497
32Abnormal rod and cone electroretinograms (HP:0008323)2.39178773
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.36746775
34Visual hallucinations (HP:0002367)2.34577417
35Large for gestational age (HP:0001520)2.31903060
36Medial flaring of the eyebrow (HP:0010747)2.29160192
37Ketosis (HP:0001946)2.28217245
38Lissencephaly (HP:0001339)2.27253524
39Thyroiditis (HP:0100646)2.26563278
40Renal cortical cysts (HP:0000803)2.21236534
41Panhypogammaglobulinemia (HP:0003139)2.20938637
42Polyuria (HP:0000103)2.20069924
43Absence seizures (HP:0002121)2.19955310
44Stomatitis (HP:0010280)2.19501189
45Generalized tonic-clonic seizures (HP:0002069)2.17122365
46Cystic liver disease (HP:0006706)2.15245556
47Methylmalonic aciduria (HP:0012120)2.12845267
48Decreased central vision (HP:0007663)2.10623863
49Methylmalonic acidemia (HP:0002912)2.07261482
50Increased CSF lactate (HP:0002490)2.04567330
51Clumsiness (HP:0002312)2.03284496
52Atonic seizures (HP:0010819)2.03203721
53Absent speech (HP:0001344)2.00787921
54Mitochondrial inheritance (HP:0001427)2.00446665
55Cerebellar dysplasia (HP:0007033)2.00323082
56Neoplasm of the adrenal cortex (HP:0100641)1.99838790
57Pachygyria (HP:0001302)1.97032840
58Metabolic alkalosis (HP:0200114)1.96048344
59Status epilepticus (HP:0002133)1.95760340
60Bony spicule pigmentary retinopathy (HP:0007737)1.95091110
61Hypothermia (HP:0002045)1.94873199
62Polyphagia (HP:0002591)1.92967109
63Albinism (HP:0001022)1.92922547
64Fair hair (HP:0002286)1.91858730
65Widely spaced teeth (HP:0000687)1.90770635
66Hemiplegia (HP:0002301)1.90276401
67Calf muscle hypertrophy (HP:0008981)1.90252958
68Pendular nystagmus (HP:0012043)1.90229372
69Severe muscular hypotonia (HP:0006829)1.88271188
70Agitation (HP:0000713)1.86029793
71Abnormal delayed hypersensitivity skin test (HP:0002963)1.84979716
72Hepatocellular necrosis (HP:0001404)1.84271144
73Dyskinesia (HP:0100660)1.83875590
74Prolonged QT interval (HP:0001657)1.83099168
75Abnormality of B cell number (HP:0010975)1.81773922
76Stomach cancer (HP:0012126)1.81371606
77Tubular atrophy (HP:0000092)1.80865211
78Hepatic necrosis (HP:0002605)1.80754844
79Muscle hypertrophy of the lower extremities (HP:0008968)1.80615761
80Gait imbalance (HP:0002141)1.80020073
81Abnormal urine output (HP:0012590)1.78083822
82Congenital sensorineural hearing impairment (HP:0008527)1.74591735
83Progressive macrocephaly (HP:0004481)1.73463384
84Progressive microcephaly (HP:0000253)1.72725958
85Lipid accumulation in hepatocytes (HP:0006561)1.71963128
86Retinal dysplasia (HP:0007973)1.71376116
87Optic disc pallor (HP:0000543)1.69173482
88Congenital hepatic fibrosis (HP:0002612)1.68594723
89Epileptiform EEG discharges (HP:0011182)1.67481132
90Hyperglycinuria (HP:0003108)1.66293660
91Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65961161
92Amyotrophic lateral sclerosis (HP:0007354)1.65516625
93EEG with generalized epileptiform discharges (HP:0011198)1.64848428
94Tachypnea (HP:0002789)1.64618116
95Hypsarrhythmia (HP:0002521)1.63584665
96Abnormality of renin-angiotensin system (HP:0000847)1.61366840
97Hematochezia (HP:0002573)1.60020319
98Bundle branch block (HP:0011710)1.60001634
99Hypomagnesemia (HP:0002917)1.59863643
100Generalized hypopigmentation of hair (HP:0011358)1.59720743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.19577845
2ADRBK22.97354946
3PINK12.91255939
4DAPK22.35323523
5BMPR1B2.34207075
6GRK12.28839998
7TAOK32.25949805
8MAPK132.16674277
9MAP4K22.13458412
10PHKG11.99100644
11PHKG21.99100644
12MARK11.92801376
13WNK41.90980690
14NTRK31.63022546
15PAK31.60761776
16TLK11.59404359
17INSRR1.56665237
18MAP3K41.51782362
19WNK31.50965911
20OBSCN1.48573664
21ZAK1.48336005
22TXK1.46499971
23OXSR11.44264072
24CAMKK21.41469352
25EPHA41.36921977
26SIK21.30294810
27ACVR1B1.29635687
28CASK1.23743824
29FGFR21.18683333
30NTRK21.13670378
31TNK21.12823528
32NUAK11.12289146
33CAMKK11.11863213
34TNIK1.08895239
35KIT1.05470557
36PAK61.01403300
37SYK0.96071270
38STK390.95992994
39STK110.94613344
40PLK20.92499317
41CAMK10.92301530
42ADRBK10.91993843
43PRKCE0.89855200
44PRKCQ0.88299338
45PRKCG0.83399558
46LMTK20.82929844
47ITK0.80913445
48MAP4K10.80429146
49MUSK0.74172036
50PRKD30.73983055
51MAP2K60.71415020
52TRIM280.71369241
53SGK20.70624211
54TEC0.68266858
55PTK2B0.68167128
56CAMK2A0.66780655
57PKN10.66604377
58CAMK40.65108721
59MINK10.64784319
60PIK3CA0.64741151
61MAP2K70.63318394
62DYRK1A0.62322784
63BCKDK0.61743369
64GRK60.60450602
65PRKCI0.59894112
66PRKAA10.59375287
67MAPKAPK30.58409074
68MAPK120.57184823
69FLT30.57150273
70IKBKB0.57122749
71AKT30.55720598
72PRKG10.55132805
73SGK2230.54427988
74SGK4940.54427988
75PRKACA0.53708046
76NLK0.53614943
77MAP3K70.53270526
78FES0.53026583
79CAMK2D0.51272779
80GRK50.50889531
81GRK70.50872670
82IKBKE0.48515164
83PIK3CG0.46945863
84PRKCH0.46720557
85DYRK20.46131221
86MAP2K40.45180210
87CSNK1G20.44994806
88SIK30.44968544
89CDK50.44442480
90PRKAA20.43271891
91PRKCZ0.43060072
92CSF1R0.42387479
93TGFBR10.42298134
94WNK10.42160512
95CSNK1A1L0.41738193
96HIPK20.41448980
97IRAK10.41113090
98PRKCA0.40503844
99LYN0.39754995
100BLK0.39616796

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.80152698
2Caffeine metabolism_Homo sapiens_hsa002322.77344597
3Nicotine addiction_Homo sapiens_hsa050332.47342245
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30248107
5Linoleic acid metabolism_Homo sapiens_hsa005912.10379305
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.00771756
7Insulin secretion_Homo sapiens_hsa049111.99604171
8Butanoate metabolism_Homo sapiens_hsa006501.99368411
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.97723246
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93737913
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90197681
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85138154
13Morphine addiction_Homo sapiens_hsa050321.84195487
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82896674
15Olfactory transduction_Homo sapiens_hsa047401.79904820
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.75506368
17Circadian entrainment_Homo sapiens_hsa047131.73949744
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73827907
19Asthma_Homo sapiens_hsa053101.72061992
20Primary immunodeficiency_Homo sapiens_hsa053401.62879657
21Nitrogen metabolism_Homo sapiens_hsa009101.62298622
22GABAergic synapse_Homo sapiens_hsa047271.58185654
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53870987
24Tryptophan metabolism_Homo sapiens_hsa003801.52984894
25Glutamatergic synapse_Homo sapiens_hsa047241.50481406
26Taste transduction_Homo sapiens_hsa047421.49909791
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49050426
28Ether lipid metabolism_Homo sapiens_hsa005651.45351893
29Peroxisome_Homo sapiens_hsa041461.43859845
30ABC transporters_Homo sapiens_hsa020101.43346570
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38374658
32Calcium signaling pathway_Homo sapiens_hsa040201.32901255
33Circadian rhythm_Homo sapiens_hsa047101.31595115
34Regulation of autophagy_Homo sapiens_hsa041401.30644274
35Type I diabetes mellitus_Homo sapiens_hsa049401.22933893
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22880632
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.19211162
38Selenocompound metabolism_Homo sapiens_hsa004501.18571350
39Salivary secretion_Homo sapiens_hsa049701.15772452
40Gastric acid secretion_Homo sapiens_hsa049711.13763244
41Synaptic vesicle cycle_Homo sapiens_hsa047211.10021023
42Collecting duct acid secretion_Homo sapiens_hsa049661.08161902
43Allograft rejection_Homo sapiens_hsa053301.05054081
44Oxidative phosphorylation_Homo sapiens_hsa001901.02741976
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02435437
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01832564
47Cardiac muscle contraction_Homo sapiens_hsa042600.98500532
48Ovarian steroidogenesis_Homo sapiens_hsa049130.98359936
49Serotonergic synapse_Homo sapiens_hsa047260.97701311
50Amphetamine addiction_Homo sapiens_hsa050310.97243194
51Dopaminergic synapse_Homo sapiens_hsa047280.96896245
52Oxytocin signaling pathway_Homo sapiens_hsa049210.95413506
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94414404
54beta-Alanine metabolism_Homo sapiens_hsa004100.92327647
55Autoimmune thyroid disease_Homo sapiens_hsa053200.91568746
56Chemical carcinogenesis_Homo sapiens_hsa052040.90052861
57Renin secretion_Homo sapiens_hsa049240.88768678
58Retinol metabolism_Homo sapiens_hsa008300.88575192
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84896936
60Dorso-ventral axis formation_Homo sapiens_hsa043200.83532385
61Graft-versus-host disease_Homo sapiens_hsa053320.83167933
62Arachidonic acid metabolism_Homo sapiens_hsa005900.82277435
63Propanoate metabolism_Homo sapiens_hsa006400.82033629
64Cholinergic synapse_Homo sapiens_hsa047250.81479328
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.79962828
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79151296
67Histidine metabolism_Homo sapiens_hsa003400.78317042
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71595444
69cAMP signaling pathway_Homo sapiens_hsa040240.70576647
70Parkinsons disease_Homo sapiens_hsa050120.69078381
71Fatty acid degradation_Homo sapiens_hsa000710.68532926
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66401599
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65972840
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.65804913
75Bile secretion_Homo sapiens_hsa049760.65695059
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63862316
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62673439
78Fanconi anemia pathway_Homo sapiens_hsa034600.61500426
79Cocaine addiction_Homo sapiens_hsa050300.60176575
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58945950
81RNA degradation_Homo sapiens_hsa030180.55497845
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54284596
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53395253
84Long-term depression_Homo sapiens_hsa047300.52925740
85RNA polymerase_Homo sapiens_hsa030200.52752836
86Type II diabetes mellitus_Homo sapiens_hsa049300.49777188
87Protein export_Homo sapiens_hsa030600.49772574
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48174407
89Lysine degradation_Homo sapiens_hsa003100.46967416
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46712456
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46443732
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45189573
93Alzheimers disease_Homo sapiens_hsa050100.44462253
94Staphylococcus aureus infection_Homo sapiens_hsa051500.44327442
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44061996
96Basal transcription factors_Homo sapiens_hsa030220.44043893
97Rheumatoid arthritis_Homo sapiens_hsa053230.43341397
98Glucagon signaling pathway_Homo sapiens_hsa049220.41677561
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41244516
100Pancreatic secretion_Homo sapiens_hsa049720.40650723

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »