THYN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.21892652
2ribosomal small subunit assembly (GO:0000028)5.14589793
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.89521926
4ribosomal small subunit biogenesis (GO:0042274)4.62977365
5establishment of integrated proviral latency (GO:0075713)4.62211972
6ATP synthesis coupled proton transport (GO:0015986)4.50601336
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.50601336
8protein complex biogenesis (GO:0070271)4.48782940
9viral transcription (GO:0019083)4.46002576
10maturation of SSU-rRNA (GO:0030490)4.45877916
11translational termination (GO:0006415)4.39759227
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.36138469
13electron transport chain (GO:0022900)4.35514964
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.31171479
15formation of translation preinitiation complex (GO:0001731)4.29212415
16mitochondrial respiratory chain complex assembly (GO:0033108)4.25344830
17DNA strand elongation involved in DNA replication (GO:0006271)4.21316856
18DNA deamination (GO:0045006)4.19975486
19ribosomal large subunit biogenesis (GO:0042273)4.13418042
20cullin deneddylation (GO:0010388)4.11919021
21DNA replication initiation (GO:0006270)4.11898090
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.08072719
23regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.01853771
24negative regulation of ligase activity (GO:0051352)4.01849812
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.01849812
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.01490565
27cotranslational protein targeting to membrane (GO:0006613)4.00289282
28translational elongation (GO:0006414)3.97987373
29DNA strand elongation (GO:0022616)3.96750436
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.95946511
31telomere maintenance via semi-conservative replication (GO:0032201)3.94210970
327-methylguanosine mRNA capping (GO:0006370)3.94033700
33respiratory chain complex IV assembly (GO:0008535)3.93174545
34protein targeting to ER (GO:0045047)3.93093219
35nucleobase biosynthetic process (GO:0046112)3.92937179
36purine nucleobase biosynthetic process (GO:0009113)3.91989189
377-methylguanosine RNA capping (GO:0009452)3.90887719
38RNA capping (GO:0036260)3.90887719
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.90706511
40regulation of mitochondrial translation (GO:0070129)3.90394342
41regulation of cellular amino acid metabolic process (GO:0006521)3.87246956
42ribonucleoprotein complex biogenesis (GO:0022613)3.85488440
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.84926835
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.84926835
45protein deneddylation (GO:0000338)3.82310611
46translational initiation (GO:0006413)3.82222467
47signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.80488793
48signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.80488793
49signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.80488793
50spliceosomal snRNP assembly (GO:0000387)3.79845597
51establishment of viral latency (GO:0019043)3.79757050
52termination of RNA polymerase III transcription (GO:0006386)3.78191663
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.78191663
54protein localization to endoplasmic reticulum (GO:0070972)3.76509670
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.74402073
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.74402073
57cytochrome complex assembly (GO:0017004)3.72737100
58establishment of protein localization to endoplasmic reticulum (GO:0072599)3.72606527
59CENP-A containing nucleosome assembly (GO:0034080)3.71054500
60signal transduction involved in cell cycle checkpoint (GO:0072395)3.69023014
61translation (GO:0006412)3.67642165
62GTP biosynthetic process (GO:0006183)3.66723908
63histone exchange (GO:0043486)3.65649955
64chromatin remodeling at centromere (GO:0031055)3.61905240
65cellular protein complex disassembly (GO:0043624)3.60493036
66rRNA processing (GO:0006364)3.59974253
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.58112656
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.57579940
69pseudouridine synthesis (GO:0001522)3.56387837
70telomere maintenance via recombination (GO:0000722)3.55801299
71oxidative phosphorylation (GO:0006119)3.55340058
72DNA double-strand break processing (GO:0000729)3.55163777
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54859189
74viral life cycle (GO:0019058)3.53753839
75protein neddylation (GO:0045116)3.52529423
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51814541
77regulation of mitotic spindle checkpoint (GO:1903504)3.51814541
78UTP biosynthetic process (GO:0006228)3.51056910
79transcription-coupled nucleotide-excision repair (GO:0006283)3.50332107
80chaperone-mediated protein transport (GO:0072321)3.49818427
81spliceosomal complex assembly (GO:0000245)3.49732373
82DNA unwinding involved in DNA replication (GO:0006268)3.49708991
83ribosome biogenesis (GO:0042254)3.46656297
84rRNA metabolic process (GO:0016072)3.44401427
85positive regulation of ligase activity (GO:0051351)3.44374856
86cellular component biogenesis (GO:0044085)3.42032336
87rRNA modification (GO:0000154)3.40085347
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38828832
89guanosine-containing compound biosynthetic process (GO:1901070)3.38514919
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.36899939
91establishment of protein localization to mitochondrion (GO:0072655)3.36619603
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.33149745
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.33149745
94inner mitochondrial membrane organization (GO:0007007)3.32879496
95ribosome assembly (GO:0042255)3.32134928
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.32091787
97nucleotide-excision repair, DNA gap filling (GO:0006297)3.30784558
98cell cycle G1/S phase transition (GO:0044843)3.29836960
99G1/S transition of mitotic cell cycle (GO:0000082)3.29836960
100protein-cofactor linkage (GO:0018065)3.29490709
101transcription elongation from RNA polymerase I promoter (GO:0006362)3.29458021
102DNA replication checkpoint (GO:0000076)3.28652301
103DNA ligation (GO:0006266)3.28269730
104mitotic recombination (GO:0006312)3.27013038
105protein targeting to mitochondrion (GO:0006626)3.26994050
106respiratory electron transport chain (GO:0022904)3.25162943
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24127491
108termination of RNA polymerase I transcription (GO:0006363)3.23156471
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23019849
110IMP biosynthetic process (GO:0006188)3.22651839
111regulation of ubiquitin-protein transferase activity (GO:0051438)3.21510095
112DNA replication-independent nucleosome organization (GO:0034724)3.20368509
113DNA replication-independent nucleosome assembly (GO:0006336)3.20368509
114mitochondrial respiratory chain complex I assembly (GO:0032981)3.19356185
115NADH dehydrogenase complex assembly (GO:0010257)3.19356185
116mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19356185
117DNA catabolic process, exonucleolytic (GO:0000738)3.16089181
118DNA damage response, detection of DNA damage (GO:0042769)3.15194971
119mismatch repair (GO:0006298)3.02868088
120ATP biosynthetic process (GO:0006754)3.00453387
121hydrogen ion transmembrane transport (GO:1902600)2.94000396
122regulation of meiosis I (GO:0060631)2.91364509
123water-soluble vitamin biosynthetic process (GO:0042364)2.90924334
124histone mRNA metabolic process (GO:0008334)2.89277841
125synapsis (GO:0007129)2.85128232
126regulation of helicase activity (GO:0051095)2.84912115
127regulation of ligase activity (GO:0051340)2.84769613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.33376219
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.71283548
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.52955846
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.10358418
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.06796895
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82390224
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68531527
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.46753278
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.37130159
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.27738428
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20254621
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17614014
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.14715667
14MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13473653
15MYC_19030024_ChIP-ChIP_MESCs_Mouse3.06389065
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06018348
17* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03205586
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.02181697
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96943222
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84737758
21* VDR_23849224_ChIP-Seq_CD4+_Human2.60834007
22XRN2_22483619_ChIP-Seq_HELA_Human2.47673567
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43187781
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41608092
25* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.39554356
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.38827052
27* DCP1A_22483619_ChIP-Seq_HELA_Human2.33547638
28ELK1_19687146_ChIP-ChIP_HELA_Human2.28696045
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24965011
30* FOXP3_21729870_ChIP-Seq_TREG_Human2.20903972
31TTF2_22483619_ChIP-Seq_HELA_Human2.11583510
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.11164399
33ZNF274_21170338_ChIP-Seq_K562_Hela2.06644207
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.05392218
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05012695
36YY1_21170310_ChIP-Seq_MESCs_Mouse2.01784724
37GABP_19822575_ChIP-Seq_HepG2_Human2.01055898
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98978864
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96303381
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95448278
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92401026
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86743190
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85693210
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84636948
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83599359
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.81968532
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78821289
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69648272
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65483390
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.62319204
51VDR_22108803_ChIP-Seq_LS180_Human1.61640774
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59883478
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57670055
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.55825775
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51086677
56AR_21909140_ChIP-Seq_LNCAP_Human1.48013644
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47162947
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42253078
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41443365
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.36954764
61* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34535490
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31831905
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30130143
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.29684782
65MYC_18940864_ChIP-ChIP_HL60_Human1.27045090
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26016004
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25203660
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23725108
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22852413
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21950702
71* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19759313
72TAF15_26573619_Chip-Seq_HEK293_Human1.19014671
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16679935
74IGF1R_20145208_ChIP-Seq_DFB_Human1.15273439
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14806966
76KDM5A_27292631_Chip-Seq_BREAST_Human1.14669362
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13945613
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12675565
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12063383
80P300_19829295_ChIP-Seq_ESCs_Human1.11975302
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08781310
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08091675
83CIITA_25753668_ChIP-Seq_RAJI_Human1.07761423
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05290119
85HTT_18923047_ChIP-ChIP_STHdh_Human1.04004912
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03000183
87TP53_22573176_ChIP-Seq_HFKS_Human1.02876948
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00988484
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00395748
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99621496
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99523828
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99032455
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98404605
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98402010
95* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94675527
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93389613
97TFEB_21752829_ChIP-Seq_HELA_Human0.93029916
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91876447
99IRF1_19129219_ChIP-ChIP_H3396_Human0.91306031
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90359239
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89370377
102* SOX17_20123909_ChIP-Seq_XEN_Mouse0.89364051
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88108379
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87756704
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87307402
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85925111
107NANOG_19829295_ChIP-Seq_ESCs_Human0.83527940
108SOX2_19829295_ChIP-Seq_ESCs_Human0.83527940
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82854790
110GBX2_23144817_ChIP-Seq_PC3_Human0.82548864
111* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82257522
112* FOXA1_25329375_ChIP-Seq_VCAP_Human0.82257522
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81696074
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81448006
115SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80079158
116NFE2_27457419_Chip-Seq_LIVER_Mouse0.79354175
117EZH2_22144423_ChIP-Seq_EOC_Human0.79099892
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.78510212
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.78328310
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.77830328
121CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76252186
122FUS_26573619_Chip-Seq_HEK293_Human0.75802276
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75578381
124KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75029683
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72860304
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72859800
127OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72666191
128SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71175980
129NANOG_16153702_ChIP-ChIP_HESCs_Human0.70989676
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70146597
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.69912367
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.69380680
133EWS_26573619_Chip-Seq_HEK293_Human0.68597783
134TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.65955430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.46326291
2MP0004957_abnormal_blastocyst_morpholog4.29271582
3MP0010094_abnormal_chromosome_stability4.05325285
4MP0008057_abnormal_DNA_replication3.78098456
5MP0008058_abnormal_DNA_repair3.60410646
6MP0003077_abnormal_cell_cycle3.38909115
7MP0003111_abnormal_nucleus_morphology3.23482533
8MP0009379_abnormal_foot_pigmentation3.09143997
9MP0001529_abnormal_vocalization3.06812233
10MP0008877_abnormal_DNA_methylation3.01463536
11MP0008932_abnormal_embryonic_tissue3.01224545
12MP0003123_paternal_imprinting2.88675128
13MP0008007_abnormal_cellular_replicative2.32792234
14MP0003786_premature_aging2.23812535
15MP0003806_abnormal_nucleotide_metabolis2.22452668
16MP0006292_abnormal_olfactory_placode2.18645153
17MP0003136_yellow_coat_color2.16801541
18MP0003880_abnormal_central_pattern2.00564457
19MP0001984_abnormal_olfaction1.95517903
20MP0003787_abnormal_imprinting1.92947848
21MP0003718_maternal_effect1.82272029
22MP0001730_embryonic_growth_arrest1.72809128
23MP0001905_abnormal_dopamine_level1.72233269
24MP0003186_abnormal_redox_activity1.69137867
25MP0003011_delayed_dark_adaptation1.68698840
26MP0003121_genomic_imprinting1.64313167
27MP0002837_dystrophic_cardiac_calcinosis1.64067133
28MP0008995_early_reproductive_senescence1.61395279
29MP0000350_abnormal_cell_proliferation1.60490313
30MP0006036_abnormal_mitochondrial_physio1.58239543
31MP0002102_abnormal_ear_morphology1.58106558
32MP0002396_abnormal_hematopoietic_system1.54951332
33MP0005551_abnormal_eye_electrophysiolog1.53340242
34MP0004133_heterotaxia1.48889345
35MP0002938_white_spotting1.43771656
36MP0002160_abnormal_reproductive_system1.42159629
37MP0006035_abnormal_mitochondrial_morpho1.41787819
38MP0005075_abnormal_melanosome_morpholog1.36846107
39MP0004142_abnormal_muscle_tone1.32817667
40MP0009697_abnormal_copulation1.32174660
41MP0005084_abnormal_gallbladder_morpholo1.29550286
42MP0003315_abnormal_perineum_morphology1.27687863
43MP0001188_hyperpigmentation1.26440152
44MP0010030_abnormal_orbit_morphology1.25189813
45MP0002234_abnormal_pharynx_morphology1.24451309
46MP0002210_abnormal_sex_determination1.23306754
47MP0001697_abnormal_embryo_size1.20813182
48MP0003195_calcinosis1.19569836
49MP0002638_abnormal_pupillary_reflex1.18062859
50MP0005645_abnormal_hypothalamus_physiol1.17520047
51MP0002736_abnormal_nociception_after1.16710323
52MP0000372_irregular_coat_pigmentation1.15554643
53MP0000313_abnormal_cell_death1.13607519
54MP0001145_abnormal_male_reproductive1.13288678
55MP0002132_abnormal_respiratory_system1.12449280
56MP0005646_abnormal_pituitary_gland1.12117672
57MP0000490_abnormal_crypts_of1.11369282
58MP0000358_abnormal_cell_content/1.09853213
59MP0009745_abnormal_behavioral_response1.08939395
60MP0001293_anophthalmia1.08772533
61MP0003122_maternal_imprinting1.07972700
62MP0002080_prenatal_lethality1.07326323
63MP0002090_abnormal_vision1.06426401
64MP0001727_abnormal_embryo_implantation1.04861705
65MP0000566_synostosis1.04639776
66MP0005389_reproductive_system_phenotype0.99478658
67MP0009046_muscle_twitch0.99089284
68MP0001929_abnormal_gametogenesis0.98851109
69MP0006276_abnormal_autonomic_nervous0.97742525
70MP0002751_abnormal_autonomic_nervous0.96320068
71MP0000653_abnormal_sex_gland0.96222240
72MP0002085_abnormal_embryonic_tissue0.94773705
73MP0001485_abnormal_pinna_reflex0.94089009
74MP0002163_abnormal_gland_morphology0.91267626
75MP0006072_abnormal_retinal_apoptosis0.91086187
76MP0005266_abnormal_metabolism0.89800110
77MP0005380_embryogenesis_phenotype0.89568832
78MP0001672_abnormal_embryogenesis/_devel0.89568832
79MP0001486_abnormal_startle_reflex0.87793535
80MP0002019_abnormal_tumor_incidence0.86162019
81MP0008875_abnormal_xenobiotic_pharmacok0.86156086
82MP0002233_abnormal_nose_morphology0.86095918
83MP0004215_abnormal_myocardial_fiber0.86026597
84MP0008789_abnormal_olfactory_epithelium0.83797467
85MP0005395_other_phenotype0.83105777
86MP0009333_abnormal_splenocyte_physiolog0.82075303
87MP0000049_abnormal_middle_ear0.81661314
88MP0002653_abnormal_ependyma_morphology0.81293628
89MP0001968_abnormal_touch/_nociception0.80979107
90MP0002084_abnormal_developmental_patter0.80485168
91MP0005391_vision/eye_phenotype0.80291330
92MP0004808_abnormal_hematopoietic_stem0.77336301
93MP0001986_abnormal_taste_sensitivity0.76541943
94MP0001764_abnormal_homeostasis0.76409750
95MP0002734_abnormal_mechanical_nocicepti0.75883829
96MP0003890_abnormal_embryonic-extraembry0.73270437
97MP0000647_abnormal_sebaceous_gland0.72763043
98MP0003984_embryonic_growth_retardation0.72275488
99MP0002557_abnormal_social/conspecific_i0.71865302
100MP0003698_abnormal_male_reproductive0.71362152
101MP0005379_endocrine/exocrine_gland_phen0.69375976
102MP0010386_abnormal_urinary_bladder0.69024233
103MP0001853_heart_inflammation0.68488711
104MP0003119_abnormal_digestive_system0.68408101
105MP0001440_abnormal_grooming_behavior0.68251250
106MP0003567_abnormal_fetal_cardiomyocyte0.67700888
107MP0010307_abnormal_tumor_latency0.67537410
108MP0003137_abnormal_impulse_conducting0.67026156
109MP0005195_abnormal_posterior_eye0.67024677
110MP0002088_abnormal_embryonic_growth/wei0.66681040
111MP0005410_abnormal_fertilization0.65535597
112MP0002752_abnormal_somatic_nervous0.65403167
113MP0004197_abnormal_fetal_growth/weight/0.65221799
114MP0005171_absent_coat_pigmentation0.64391148
115MP0004147_increased_porphyrin_level0.64245162
116MP0002095_abnormal_skin_pigmentation0.63769958
117MP0002161_abnormal_fertility/fecundity0.63200530
118MP0003938_abnormal_ear_development0.59269093
119MP0003941_abnormal_skin_development0.59262959
120MP0001119_abnormal_female_reproductive0.59149851
121MP0005394_taste/olfaction_phenotype0.57969696
122MP0005499_abnormal_olfactory_system0.57969696
123MP0004924_abnormal_behavior0.57608090
124MP0005386_behavior/neurological_phenoty0.57608090
125MP0000631_abnormal_neuroendocrine_gland0.57377198
126MP0001286_abnormal_eye_development0.56871381
127MP0005408_hypopigmentation0.56816656
128MP0005253_abnormal_eye_physiology0.55819025
129MP0008872_abnormal_physiological_respon0.55731612
130MP0001919_abnormal_reproductive_system0.55655874
131MP0002735_abnormal_chemical_nociception0.55570251
132MP0002277_abnormal_respiratory_mucosa0.55404166
133MP0005384_cellular_phenotype0.55180690
134MP0002272_abnormal_nervous_system0.54352351

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.13548166
2Mitochondrial inheritance (HP:0001427)4.71246349
3Abnormal mitochondria in muscle tissue (HP:0008316)4.70098930
4Abnormality of cells of the erythroid lineage (HP:0012130)4.63866149
5Abnormal number of erythroid precursors (HP:0012131)4.35024057
6Birth length less than 3rd percentile (HP:0003561)4.29977764
7Increased hepatocellular lipid droplets (HP:0006565)4.24190061
8Increased CSF lactate (HP:0002490)4.20472296
9Progressive macrocephaly (HP:0004481)4.12838736
10Hepatocellular necrosis (HP:0001404)4.11421642
11Acute encephalopathy (HP:0006846)3.96216063
12Reticulocytopenia (HP:0001896)3.91550383
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.86380795
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.86380795
15Increased serum pyruvate (HP:0003542)3.77517341
16Abnormality of glycolysis (HP:0004366)3.77517341
17Cerebral hypomyelination (HP:0006808)3.68867928
18Lipid accumulation in hepatocytes (HP:0006561)3.62939738
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.56942818
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.51448713
21Aplastic anemia (HP:0001915)3.37827453
22Hepatic necrosis (HP:0002605)3.36659146
23Increased serum lactate (HP:0002151)3.33760207
24Macrocytic anemia (HP:0001972)3.27873126
25Renal Fanconi syndrome (HP:0001994)3.23544181
26Oral leukoplakia (HP:0002745)3.22475799
27Breast hypoplasia (HP:0003187)3.14864243
28Exercise intolerance (HP:0003546)3.14469865
29Increased intramyocellular lipid droplets (HP:0012240)3.01552312
30Exertional dyspnea (HP:0002875)3.00739099
31Methylmalonic acidemia (HP:0002912)2.96552574
32Pallor (HP:0000980)2.83231603
333-Methylglutaconic aciduria (HP:0003535)2.82631679
34Respiratory failure (HP:0002878)2.73618706
35Leukodystrophy (HP:0002415)2.73599771
36Lactic acidosis (HP:0003128)2.69785730
37Respiratory difficulties (HP:0002880)2.65364241
38Rough bone trabeculation (HP:0100670)2.62788653
39Agnosia (HP:0010524)2.61040064
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56834385
41Degeneration of anterior horn cells (HP:0002398)2.54268965
42Abnormality of the anterior horn cell (HP:0006802)2.54268965
43Methylmalonic aciduria (HP:0012120)2.52584272
44CNS hypomyelination (HP:0003429)2.49559040
45Supernumerary spleens (HP:0009799)2.48007715
46Cerebral edema (HP:0002181)2.47357633
47Abnormality of the labia minora (HP:0012880)2.46473743
4811 pairs of ribs (HP:0000878)2.45583122
49Hyperglycinemia (HP:0002154)2.44623386
50Septo-optic dysplasia (HP:0100842)2.41782638
51Colon cancer (HP:0003003)2.41231517
52Type I transferrin isoform profile (HP:0003642)2.31209432
53Lethargy (HP:0001254)2.30782322
54Abnormality of methionine metabolism (HP:0010901)2.30302729
55Increased muscle lipid content (HP:0009058)2.29673567
56Premature graying of hair (HP:0002216)2.28490223
57Optic disc pallor (HP:0000543)2.28472934
58Emotional lability (HP:0000712)2.23716190
59Abnormal lung lobation (HP:0002101)2.23235411
60Postnatal microcephaly (HP:0005484)2.22877169
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22386479
62Nephronophthisis (HP:0000090)2.22228417
63Carpal bone hypoplasia (HP:0001498)2.20823696
64Microretrognathia (HP:0000308)2.17669170
65Abnormality of serum amino acid levels (HP:0003112)2.17010416
66Selective tooth agenesis (HP:0001592)2.15883481
67Abnormality of midbrain morphology (HP:0002418)2.15651982
68Molar tooth sign on MRI (HP:0002419)2.15651982
69Abnormal trabecular bone morphology (HP:0100671)2.10369431
70Abnormality of the preputium (HP:0100587)2.10202631
71Abnormality of renal resorption (HP:0011038)2.09431321
72Asplenia (HP:0001746)2.06878823
73Patellar aplasia (HP:0006443)2.06324594
74Glycosuria (HP:0003076)2.06066776
75Abnormality of urine glucose concentration (HP:0011016)2.06066776
76Chromsome breakage (HP:0040012)2.05222477
77Absent radius (HP:0003974)2.04055910
78Horseshoe kidney (HP:0000085)2.03706323
79Hypoglycemic coma (HP:0001325)2.03623785
80CNS demyelination (HP:0007305)2.00462960
81Meckel diverticulum (HP:0002245)2.00449279
82Generalized aminoaciduria (HP:0002909)1.98444926
83Unsteady gait (HP:0002317)1.96772313
84Absent forearm bone (HP:0003953)1.96110968
85Aplasia involving forearm bones (HP:0009822)1.96110968
86Absent thumb (HP:0009777)1.95959889
87Pancytopenia (HP:0001876)1.95030135
88Congenital, generalized hypertrichosis (HP:0004540)1.93940998
89Dicarboxylic aciduria (HP:0003215)1.93081394
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93081394
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.92745447
92Renal cortical cysts (HP:0000803)1.92137734
93Hyperglycinuria (HP:0003108)1.91739775
94Bone marrow hypocellularity (HP:0005528)1.91727333
95Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91608503
96Abnormality of the ileum (HP:0001549)1.90409218
97Aplasia/Hypoplasia of the patella (HP:0006498)1.90363679
98Intestinal atresia (HP:0011100)1.89257967
99Sclerocornea (HP:0000647)1.88210656
100Abnormal number of incisors (HP:0011064)1.88177558
101Abnormality of glycine metabolism (HP:0010895)1.86002968
102Abnormality of serine family amino acid metabolism (HP:0010894)1.86002968
103True hermaphroditism (HP:0010459)1.85948344
104Absent septum pellucidum (HP:0001331)1.85925451
105Stenosis of the external auditory canal (HP:0000402)1.83105560
106Hypothermia (HP:0002045)1.82906767
107Megaloblastic anemia (HP:0001889)1.82662165
108Microvesicular hepatic steatosis (HP:0001414)1.82203270
109Abnormal protein N-linked glycosylation (HP:0012347)1.82041244
110Abnormal protein glycosylation (HP:0012346)1.82041244
111Abnormal glycosylation (HP:0012345)1.82041244
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82041244
113Triphalangeal thumb (HP:0001199)1.81931178
114Pancreatic fibrosis (HP:0100732)1.81656598
115X-linked dominant inheritance (HP:0001423)1.81392810
116Abnormality of chromosome stability (HP:0003220)1.81121341
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80889806
118Cellular immunodeficiency (HP:0005374)1.80642813
119Pancreatic cysts (HP:0001737)1.80050500
120Cleft eyelid (HP:0000625)1.79436205
121Glossoptosis (HP:0000162)1.79314315
122Hyperphosphaturia (HP:0003109)1.79194107
123Poor head control (HP:0002421)1.78415598
124Hyperinsulinemic hypoglycemia (HP:0000825)1.78155676
125Facial cleft (HP:0002006)1.76536465
126Medulloblastoma (HP:0002885)1.75923914
127Medial flaring of the eyebrow (HP:0010747)1.75424991
128Optic nerve hypoplasia (HP:0000609)1.74091278
129Atrophy/Degeneration involving motor neurons (HP:0007373)1.73870026
130Small intestinal stenosis (HP:0012848)1.72553258
131Duodenal stenosis (HP:0100867)1.72553258
132Abnormality of vitamin B metabolism (HP:0004340)1.71476071
133Secondary amenorrhea (HP:0000869)1.71402624
134Missing ribs (HP:0000921)1.71157264
135Gait imbalance (HP:0002141)1.71137224
136Aplasia/Hypoplasia of the uvula (HP:0010293)1.70251445
137Congenital primary aphakia (HP:0007707)1.69962945
138Nephrogenic diabetes insipidus (HP:0009806)1.67180613
139Muscle fiber atrophy (HP:0100295)1.66672009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.80324376
2BUB14.25468282
3WEE13.78423701
4STK163.45846674
5NUAK13.13028018
6EIF2AK13.03413560
7NME22.79433765
8CDC72.76041107
9SRPK12.69099178
10VRK12.65136724
11TSSK62.58768496
12WNK32.49841868
13NME12.47182478
14MAP4K22.46288403
15ACVR1B2.24583889
16TESK22.19138521
17MKNK12.09157325
18TRIM282.01550663
19PNCK2.01418488
20PBK1.98600570
21BCKDK1.87070532
22EIF2AK31.87025774
23MAP3K121.84943359
24TAF11.78438906
25BRSK21.76591932
26PIM21.72442895
27PLK31.70688799
28TNIK1.59365747
29PLK41.58777013
30CCNB11.57892532
31PLK11.48825225
32PASK1.45528409
33MST41.42678416
34NEK11.38380330
35AURKA1.35550319
36ARAF1.32447496
37TESK11.19659033
38TLK11.17769858
39CDK71.15397805
40LIMK11.14354606
41AURKB1.12950767
42SCYL21.12638590
43ATR1.10652008
44FRK1.06132908
45TTK1.06052945
46DYRK31.05004324
47CASK1.03438726
48CDK81.02920043
49BRAF1.02090971
50CDK190.97697571
51MKNK20.97397430
52BRSK10.96716651
53PLK20.95357618
54GRK10.93984162
55MAPK130.93632624
56INSRR0.92832574
57MAP3K40.92073711
58DYRK20.91819510
59BCR0.91355875
60CSNK1G20.91273593
61DAPK10.88928185
62CSNK2A20.87279598
63CHEK20.87218413
64MUSK0.86441269
65TGFBR10.86278215
66CSNK2A10.82766112
67MYLK0.80239486
68ZAK0.79106597
69RPS6KB20.78665776
70ADRBK20.77359761
71PAK40.76942717
72NEK20.76655067
73OXSR10.74631308
74EPHA40.72834534
75TXK0.71409511
76PAK10.71360288
77ABL20.71209814
78CHEK10.70732663
79MAP2K70.70266462
80FGFR20.69739560
81EIF2AK20.67284548
82RPS6KA50.62598535
83PDK20.62110237
84PINK10.61984353
85CDK140.61155686
86CDK180.60706504
87BMPR1B0.59873795
88CSNK1G30.59814461
89KDR0.59192138
90CSNK1A1L0.58539029
91MAP3K110.57873662
92CDK11A0.57032731
93MAPKAPK50.56941666
94STK38L0.56076324
95CDK150.55901607
96YES10.55742981
97TIE10.52331007
98ATM0.48525512
99MAP3K80.46242290
100CDK20.43319081
101CDK30.43302256
102PRKCI0.42941465
103STK40.42882689
104BMPR20.42707734
105CDK40.41318457
106PIK3CG0.41135275
107CDK10.40786550
108AKT30.40197102
109CSNK1A10.37652698
110RPS6KA40.37225400
111PIM10.35153686
112UHMK10.34506732
113TEC0.34209022
114PRKCE0.33915709
115PDK40.33558343
116PDK30.33558343
117LATS20.33548243
118DAPK30.33167205
119MOS0.32939738
120PAK30.32938009
121ILK0.32891748
122GRK70.32357125
123MINK10.32160183
124CSNK1E0.31548797
125GRK50.31097793
126EPHA20.31049946
127STK30.30797833
128TAOK30.30541227
129PRKCG0.29968445
130ERBB30.29150284
131CAMK2A0.28684564
132CSNK1G10.26733910
133PRKDC0.26515357
134NEK60.26447072
135PRKACA0.25897931

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001006.68736261
2Proteasome_Homo sapiens_hsa030504.97286766
3Ribosome_Homo sapiens_hsa030104.51146289
4DNA replication_Homo sapiens_hsa030304.04372825
5RNA polymerase_Homo sapiens_hsa030203.88965281
6Mismatch repair_Homo sapiens_hsa034303.67267163
7Oxidative phosphorylation_Homo sapiens_hsa001903.34534046
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22089974
9Parkinsons disease_Homo sapiens_hsa050123.01040540
10Spliceosome_Homo sapiens_hsa030402.96129276
11Nucleotide excision repair_Homo sapiens_hsa034202.67272481
12Pyrimidine metabolism_Homo sapiens_hsa002402.65562797
13Homologous recombination_Homo sapiens_hsa034402.52876992
14RNA transport_Homo sapiens_hsa030132.48836604
15Huntingtons disease_Homo sapiens_hsa050162.48468685
16Base excision repair_Homo sapiens_hsa034102.38840382
17Protein export_Homo sapiens_hsa030602.14836931
18Alzheimers disease_Homo sapiens_hsa050102.04141849
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02821693
20Non-homologous end-joining_Homo sapiens_hsa034501.94294749
21Basal transcription factors_Homo sapiens_hsa030221.87414632
22RNA degradation_Homo sapiens_hsa030181.75403150
23Cell cycle_Homo sapiens_hsa041101.74432707
24Propanoate metabolism_Homo sapiens_hsa006401.73820997
25One carbon pool by folate_Homo sapiens_hsa006701.67716917
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56238028
27Purine metabolism_Homo sapiens_hsa002301.55144842
28Fanconi anemia pathway_Homo sapiens_hsa034601.52932372
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52373869
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52065126
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35443627
32Butanoate metabolism_Homo sapiens_hsa006501.19176911
33mRNA surveillance pathway_Homo sapiens_hsa030151.15303583
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09702911
35Peroxisome_Homo sapiens_hsa041460.99495664
36Cardiac muscle contraction_Homo sapiens_hsa042600.98905216
37Epstein-Barr virus infection_Homo sapiens_hsa051690.98073687
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95659021
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85964372
40p53 signaling pathway_Homo sapiens_hsa041150.83535183
41Glutathione metabolism_Homo sapiens_hsa004800.81812130
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.81734777
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.81262125
44Oocyte meiosis_Homo sapiens_hsa041140.78681682
45Tryptophan metabolism_Homo sapiens_hsa003800.71949929
46Systemic lupus erythematosus_Homo sapiens_hsa053220.71852296
47Collecting duct acid secretion_Homo sapiens_hsa049660.71182512
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70612391
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68551995
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67393447
51Vibrio cholerae infection_Homo sapiens_hsa051100.64787838
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62751078
53Caffeine metabolism_Homo sapiens_hsa002320.62367933
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57756948
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56718788
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56687872
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56108153
58Nitrogen metabolism_Homo sapiens_hsa009100.55373243
59Biosynthesis of amino acids_Homo sapiens_hsa012300.55015235
60Fatty acid degradation_Homo sapiens_hsa000710.53693509
61Metabolic pathways_Homo sapiens_hsa011000.53100567
62Vitamin B6 metabolism_Homo sapiens_hsa007500.53041092
63beta-Alanine metabolism_Homo sapiens_hsa004100.51807429
64Chemical carcinogenesis_Homo sapiens_hsa052040.51492823
65Fatty acid metabolism_Homo sapiens_hsa012120.50939960
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48782866
67Folate biosynthesis_Homo sapiens_hsa007900.48275209
68Pentose phosphate pathway_Homo sapiens_hsa000300.47333156
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.46234710
70Carbon metabolism_Homo sapiens_hsa012000.45985227
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.45710250
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45502206
73Retinol metabolism_Homo sapiens_hsa008300.45063442
74Type I diabetes mellitus_Homo sapiens_hsa049400.44416605
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43523367
76Alcoholism_Homo sapiens_hsa050340.43368583
77Graft-versus-host disease_Homo sapiens_hsa053320.43114752
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42931645
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41586464
80Legionellosis_Homo sapiens_hsa051340.39602036
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38965524
82Primary immunodeficiency_Homo sapiens_hsa053400.38919029
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38596251
84Vitamin digestion and absorption_Homo sapiens_hsa049770.38120715
85Linoleic acid metabolism_Homo sapiens_hsa005910.37772486
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.37680272
87Antigen processing and presentation_Homo sapiens_hsa046120.37269442
88Allograft rejection_Homo sapiens_hsa053300.36787365
89Viral carcinogenesis_Homo sapiens_hsa052030.36388488
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35695840
91Taste transduction_Homo sapiens_hsa047420.35254502
92Sulfur metabolism_Homo sapiens_hsa009200.34415023
93Olfactory transduction_Homo sapiens_hsa047400.34276211
94Phototransduction_Homo sapiens_hsa047440.33669841
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33390554
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33180861
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31834597
98Rheumatoid arthritis_Homo sapiens_hsa053230.31722159
99Fatty acid elongation_Homo sapiens_hsa000620.31603377
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31588211
101Nicotine addiction_Homo sapiens_hsa050330.30667953
102Pyruvate metabolism_Homo sapiens_hsa006200.30647186
103Arachidonic acid metabolism_Homo sapiens_hsa005900.28274829
104Herpes simplex infection_Homo sapiens_hsa051680.25216523
105Fructose and mannose metabolism_Homo sapiens_hsa000510.22525777
106N-Glycan biosynthesis_Homo sapiens_hsa005100.22471777
107Asthma_Homo sapiens_hsa053100.21237150
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20289959
109Sulfur relay system_Homo sapiens_hsa041220.20201362
110Shigellosis_Homo sapiens_hsa051310.19908382
111Phagosome_Homo sapiens_hsa041450.19611623
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18281212
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.18181020
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17114127
115HTLV-I infection_Homo sapiens_hsa051660.16706121
116Galactose metabolism_Homo sapiens_hsa000520.16252632
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12757157
118Autoimmune thyroid disease_Homo sapiens_hsa053200.10589737
119Synaptic vesicle cycle_Homo sapiens_hsa047210.10058003
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.09850027
121Thyroid cancer_Homo sapiens_hsa052160.08594728
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08103109
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07798060
124Arginine and proline metabolism_Homo sapiens_hsa003300.05883065
125TGF-beta signaling pathway_Homo sapiens_hsa043500.03848649
126Serotonergic synapse_Homo sapiens_hsa047260.03838607
127Ether lipid metabolism_Homo sapiens_hsa005650.03610125
128Regulation of autophagy_Homo sapiens_hsa041400.02319903
129Selenocompound metabolism_Homo sapiens_hsa00450-0.0528187
130Tyrosine metabolism_Homo sapiens_hsa00350-0.0492366
131Retrograde endocannabinoid signaling_Homo sapiens_hsa04723-0.0479512
132Apoptosis_Homo sapiens_hsa04210-0.0239668
133NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0016642

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