THUMPD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.74232998
2telomere maintenance via semi-conservative replication (GO:0032201)5.13522479
3DNA strand elongation involved in DNA replication (GO:0006271)5.01580073
4DNA strand elongation (GO:0022616)4.80503250
5DNA deamination (GO:0045006)4.63619666
6telomere maintenance via recombination (GO:0000722)4.52439716
7viral transcription (GO:0019083)4.47551023
8DNA replication initiation (GO:0006270)4.47105717
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.44025706
10DNA unwinding involved in DNA replication (GO:0006268)4.35404830
11translational termination (GO:0006415)4.30330594
12IMP biosynthetic process (GO:0006188)4.28691075
13DNA double-strand break processing (GO:0000729)4.13501381
14ribosomal large subunit biogenesis (GO:0042273)4.13210141
15mitotic recombination (GO:0006312)4.10575405
16translational elongation (GO:0006414)4.00677997
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.96324980
18ATP synthesis coupled proton transport (GO:0015986)3.96324980
19telomere maintenance via telomere lengthening (GO:0010833)3.91676832
20nucleotide-excision repair, DNA gap filling (GO:0006297)3.91202235
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.90598129
22nucleobase biosynthetic process (GO:0046112)3.87519509
23IMP metabolic process (GO:0046040)3.87201649
24mitochondrial respiratory chain complex assembly (GO:0033108)3.82728096
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.82604645
26protein complex biogenesis (GO:0070271)3.81068276
27replication fork processing (GO:0031297)3.76513466
28ribosomal small subunit biogenesis (GO:0042274)3.71444092
29cotranslational protein targeting to membrane (GO:0006613)3.69922091
30purine nucleobase biosynthetic process (GO:0009113)3.68942107
31protein targeting to ER (GO:0045047)3.67636591
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.66066718
33maturation of SSU-rRNA (GO:0030490)3.62467794
34regulation of mitochondrial translation (GO:0070129)3.62405834
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62285291
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.62285291
37NADH dehydrogenase complex assembly (GO:0010257)3.62285291
38chaperone-mediated protein transport (GO:0072321)3.58189370
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57798852
40formation of translation preinitiation complex (GO:0001731)3.57008792
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.52848485
42regulation of mitotic spindle checkpoint (GO:1903504)3.52848485
43respiratory chain complex IV assembly (GO:0008535)3.50061985
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48174805
45protein neddylation (GO:0045116)3.47271538
46protein localization to endoplasmic reticulum (GO:0070972)3.47270851
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.46884771
48ribonucleoprotein complex biogenesis (GO:0022613)3.45931104
49establishment of protein localization to endoplasmic reticulum (GO:0072599)3.45858705
50maturation of 5.8S rRNA (GO:0000460)3.42104964
51translational initiation (GO:0006413)3.41767818
52viral life cycle (GO:0019058)3.40873917
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.40614284
54cytochrome complex assembly (GO:0017004)3.38068523
55rRNA processing (GO:0006364)3.30694840
56pseudouridine synthesis (GO:0001522)3.29617126
57DNA replication checkpoint (GO:0000076)3.28008788
58cellular protein complex disassembly (GO:0043624)3.27823324
59CENP-A containing nucleosome assembly (GO:0034080)3.26741174
60histone exchange (GO:0043486)3.21863201
61transcription from mitochondrial promoter (GO:0006390)3.21593657
62termination of RNA polymerase III transcription (GO:0006386)3.21162152
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.21162152
64transcription-coupled nucleotide-excision repair (GO:0006283)3.19113823
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19093577
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19093577
67ribosome biogenesis (GO:0042254)3.19090692
68chromatin remodeling at centromere (GO:0031055)3.18372158
69rRNA metabolic process (GO:0016072)3.17871336
70respiratory electron transport chain (GO:0022904)3.17838157
71viral mRNA export from host cell nucleus (GO:0046784)3.17651550
72electron transport chain (GO:0022900)3.17375036
73recombinational repair (GO:0000725)3.15514233
74telomere organization (GO:0032200)3.15362702
75telomere maintenance (GO:0000723)3.14818575
76double-strand break repair via homologous recombination (GO:0000724)3.13809006
77rRNA modification (GO:0000154)3.12742635
78DNA damage response, detection of DNA damage (GO:0042769)3.12224340
79water-soluble vitamin biosynthetic process (GO:0042364)3.08155300
80pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.04567309
81kinetochore assembly (GO:0051382)3.03735852
82tRNA processing (GO:0008033)3.03473991
83regulation of helicase activity (GO:0051095)3.02754027
84protein complex disassembly (GO:0043241)3.02022098
85histone mRNA metabolic process (GO:0008334)3.01695104
86regulation of DNA endoreduplication (GO:0032875)3.00193571
87DNA catabolic process, exonucleolytic (GO:0000738)2.99010817
88rRNA methylation (GO:0031167)2.98281329
89mitochondrial RNA metabolic process (GO:0000959)2.96642215
90nuclear-transcribed mRNA catabolic process (GO:0000956)2.95366149
91spliceosomal snRNP assembly (GO:0000387)2.93228387
92macromolecular complex disassembly (GO:0032984)2.90740097
93translesion synthesis (GO:0019985)2.89408280
94platelet dense granule organization (GO:0060155)2.89341263
95mitotic nuclear envelope disassembly (GO:0007077)2.88612980
96folic acid-containing compound biosynthetic process (GO:0009396)2.88171288
97pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.87480108
98termination of RNA polymerase II transcription (GO:0006369)2.87036280
99DNA replication-independent nucleosome organization (GO:0034724)2.86296573
100DNA replication-independent nucleosome assembly (GO:0006336)2.86296573
101negative regulation of RNA splicing (GO:0033119)2.86285979
102organelle disassembly (GO:1903008)2.85920138
103proteasome assembly (GO:0043248)2.85585822
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84079699
105establishment of integrated proviral latency (GO:0075713)2.83919186
106exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83897967
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.83194965
108centriole replication (GO:0007099)2.83190842
109resolution of meiotic recombination intermediates (GO:0000712)2.82512347
110protein K6-linked ubiquitination (GO:0085020)2.82461125
111translation (GO:0006412)2.82402722
112cellular component biogenesis (GO:0044085)2.81996941
113ribosome assembly (GO:0042255)2.81948119
114mRNA catabolic process (GO:0006402)2.81168443
115negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80871830
116DNA synthesis involved in DNA repair (GO:0000731)2.78778211
117tRNA metabolic process (GO:0006399)2.77889023
118ncRNA metabolic process (GO:0034660)2.75758564
119definitive hemopoiesis (GO:0060216)2.75645566
120DNA-templated transcription, termination (GO:0006353)2.75471700
121mannosylation (GO:0097502)2.75417896
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75013096
123tRNA methylation (GO:0030488)2.74395429
124spliceosomal complex assembly (GO:0000245)2.74057935
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73740096
126RNA catabolic process (GO:0006401)2.73674783
127cullin deneddylation (GO:0010388)2.73396636
128somatic diversification of immune receptors via somatic mutation (GO:0002566)2.72472328
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.72472328
130cell cycle G1/S phase transition (GO:0044843)2.72022326
131G1/S transition of mitotic cell cycle (GO:0000082)2.72022326
132deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.71887694
133DNA duplex unwinding (GO:0032508)2.71670650
134kinetochore organization (GO:0051383)2.70777966
135regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.70689837
136pteridine-containing compound biosynthetic process (GO:0042559)2.70504731
137tRNA modification (GO:0006400)2.70035185
138protein targeting to mitochondrion (GO:0006626)2.69906216
139regulation of centriole replication (GO:0046599)2.69894246
140negative regulation of gene silencing (GO:0060969)2.69659110
141reciprocal meiotic recombination (GO:0007131)2.69554442
142reciprocal DNA recombination (GO:0035825)2.69554442
143positive regulation of histone H3-K4 methylation (GO:0051571)2.69399600
144DNA replication (GO:0006260)2.69296345
145nuclear pore organization (GO:0006999)2.68205067
146DNA geometric change (GO:0032392)2.66764042
147DNA replication-dependent nucleosome assembly (GO:0006335)2.66380153
148DNA replication-dependent nucleosome organization (GO:0034723)2.66380153
149RNA-dependent DNA replication (GO:0006278)2.64764602
150maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.62839793
151DNA topological change (GO:0006265)2.61941989
152somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61769574
153somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61769574
154isotype switching (GO:0045190)2.61769574
155ncRNA processing (GO:0034470)2.61333806
156nuclear pore complex assembly (GO:0051292)2.60503573
157negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59374419
158pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.58905522
159UMP biosynthetic process (GO:0006222)2.58905522
160UMP metabolic process (GO:0046049)2.58905522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.70792242
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.23494368
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.90709935
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20039534
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.92132470
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90310268
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.86760125
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80396426
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79462210
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77543281
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77173193
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66145295
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.65497805
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59964316
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.52673893
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49970993
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.48100760
18ZNF274_21170338_ChIP-Seq_K562_Hela2.47988433
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45405675
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.31163284
21VDR_23849224_ChIP-Seq_CD4+_Human2.30980126
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.30315308
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29287084
24EWS_26573619_Chip-Seq_HEK293_Human2.18026067
25FOXP3_21729870_ChIP-Seq_TREG_Human2.14946060
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13761314
27XRN2_22483619_ChIP-Seq_HELA_Human2.11537738
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11476412
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08564995
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06763635
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.06471132
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06204478
33FUS_26573619_Chip-Seq_HEK293_Human2.05641986
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02036097
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98823535
36MYC_22102868_ChIP-Seq_BL_Human1.96625654
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.89600109
38CIITA_25753668_ChIP-Seq_RAJI_Human1.88140914
39DCP1A_22483619_ChIP-Seq_HELA_Human1.87154813
40SCL_19346495_ChIP-Seq_HPC-7_Human1.85829425
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85607172
42VDR_22108803_ChIP-Seq_LS180_Human1.84894213
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81383947
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.80521512
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79740710
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.78731735
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76793534
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76733703
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75382096
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.74566951
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74275771
52IGF1R_20145208_ChIP-Seq_DFB_Human1.74049429
53GABP_19822575_ChIP-Seq_HepG2_Human1.72882602
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70056772
55TTF2_22483619_ChIP-Seq_HELA_Human1.69755570
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67258177
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.65744155
58* E2F1_21310950_ChIP-Seq_MCF-7_Human1.65383775
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64996762
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63944351
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63435623
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.63123400
63VDR_21846776_ChIP-Seq_THP-1_Human1.57331800
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56959170
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55189252
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.54983655
67ELK1_19687146_ChIP-ChIP_HELA_Human1.53984164
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49846735
69SPI1_23547873_ChIP-Seq_NB4_Human1.49101258
70AR_21909140_ChIP-Seq_LNCAP_Human1.47395876
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45962274
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.43575632
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43262995
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42080143
75TAF15_26573619_Chip-Seq_HEK293_Human1.39616333
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38224951
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35260272
78IRF1_19129219_ChIP-ChIP_H3396_Human1.34744294
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27453440
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25353465
81GATA1_22025678_ChIP-Seq_K562_Human1.25170654
82TP53_22573176_ChIP-Seq_HFKS_Human1.23669376
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23523340
84MYB_26560356_Chip-Seq_TH2_Human1.19936133
85* P300_19829295_ChIP-Seq_ESCs_Human1.17795378
86STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17722076
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17350405
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16800547
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15868190
90ER_23166858_ChIP-Seq_MCF-7_Human1.13347069
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13340738
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10869623
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10714607
94MYC_18940864_ChIP-ChIP_HL60_Human1.10648246
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09970210
96KDM5A_27292631_Chip-Seq_BREAST_Human1.09517626
97SOX2_16153702_ChIP-ChIP_HESCs_Human1.09323844
98TFEB_21752829_ChIP-Seq_HELA_Human1.08999018
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08567821
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08232858
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08087906
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06262572
103MYB_26560356_Chip-Seq_TH1_Human1.05943098
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05889442
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.04024635
106IRF8_21731497_ChIP-ChIP_J774_Mouse1.03406973
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02415732
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02272465
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01781655
110MAF_26560356_Chip-Seq_TH1_Human1.01511307
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01217254
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00415788
113MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00119688
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99327391
115KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98371569
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95948289
117TP63_19390658_ChIP-ChIP_HaCaT_Human0.95903133
118UTX_26944678_Chip-Seq_JUKART_Human0.95775925
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95531280
120GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94555064
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93413330
122CBP_20019798_ChIP-Seq_JUKART_Human0.91848117
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91848117
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90485379
125KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90372874
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89867249
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.88388210
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88342566
129NANOG_16153702_ChIP-ChIP_HESCs_Human0.88324402
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88257645
131ELK1_22589737_ChIP-Seq_MCF10A_Human0.87839709
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87367261
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86975632
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84918285
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84711778
136PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84705599
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.84481994
138SOX2_19829295_ChIP-Seq_ESCs_Human0.84380400
139NANOG_19829295_ChIP-Seq_ESCs_Human0.84380400
140* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83251435
141FOXA1_25329375_ChIP-Seq_VCAP_Human0.82645843
142FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82645843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.71892969
2MP0010094_abnormal_chromosome_stability3.30341560
3MP0003693_abnormal_embryo_hatching3.26124662
4MP0008058_abnormal_DNA_repair3.11812710
5MP0004957_abnormal_blastocyst_morpholog2.98987730
6MP0003077_abnormal_cell_cycle2.85646235
7MP0003111_abnormal_nucleus_morphology2.64616354
8MP0008007_abnormal_cellular_replicative2.48319330
9MP0008057_abnormal_DNA_replication2.43032707
10MP0006072_abnormal_retinal_apoptosis2.40149754
11MP0001835_abnormal_antigen_presentation2.37274266
12MP0010352_gastrointestinal_tract_polyps2.36005243
13MP0003763_abnormal_thymus_physiology2.35855377
14MP0005671_abnormal_response_to2.33319740
15MP0000490_abnormal_crypts_of2.32902333
16MP0004147_increased_porphyrin_level2.27178514
17MP0005397_hematopoietic_system_phenotyp2.26475370
18MP0001545_abnormal_hematopoietic_system2.26475370
19MP0003718_maternal_effect2.05589736
20MP0004808_abnormal_hematopoietic_stem2.00203975
21MP0002837_dystrophic_cardiac_calcinosis1.97385953
22MP0003806_abnormal_nucleotide_metabolis1.96321916
23MP0002398_abnormal_bone_marrow1.94988746
24MP0002166_altered_tumor_susceptibility1.94693112
25MP0009379_abnormal_foot_pigmentation1.92685740
26MP0001800_abnormal_humoral_immune1.80636037
27MP0003786_premature_aging1.77176727
28MP0002006_tumorigenesis1.75611258
29MP0000372_irregular_coat_pigmentation1.71646978
30MP0009785_altered_susceptibility_to1.71612431
31MP0005075_abnormal_melanosome_morpholog1.71269687
32MP0005084_abnormal_gallbladder_morpholo1.70995857
33MP0001529_abnormal_vocalization1.70811341
34MP0001873_stomach_inflammation1.69355269
35MP0005551_abnormal_eye_electrophysiolog1.68768900
36MP0000465_gastrointestinal_hemorrhage1.68768180
37MP0000689_abnormal_spleen_morphology1.67849087
38MP0002722_abnormal_immune_system1.66793509
39MP0002102_abnormal_ear_morphology1.64008732
40MP0005645_abnormal_hypothalamus_physiol1.61992431
41MP0005174_abnormal_tail_pigmentation1.59485952
42MP0003136_yellow_coat_color1.58530777
43MP0000716_abnormal_immune_system1.58235882
44MP0000685_abnormal_immune_system1.56935406
45MP0002429_abnormal_blood_cell1.54742457
46MP0002452_abnormal_antigen_presenting1.54341333
47MP0002420_abnormal_adaptive_immunity1.54028776
48MP0002723_abnormal_immune_serum1.52971732
49MP0006035_abnormal_mitochondrial_morpho1.51578645
50MP0001819_abnormal_immune_cell1.50966765
51MP0002095_abnormal_skin_pigmentation1.49408027
52MP0008932_abnormal_embryonic_tissue1.48825206
53MP0000703_abnormal_thymus_morphology1.48124980
54MP0000631_abnormal_neuroendocrine_gland1.48080727
55MP0002019_abnormal_tumor_incidence1.46921541
56MP0002160_abnormal_reproductive_system1.45486797
57MP0005253_abnormal_eye_physiology1.44790276
58MP0006292_abnormal_olfactory_placode1.44128581
59MP0000569_abnormal_digit_pigmentation1.43323701
60MP0000350_abnormal_cell_proliferation1.42272660
61MP0002132_abnormal_respiratory_system1.42104244
62MP0005025_abnormal_response_to1.40628828
63MP0000015_abnormal_ear_pigmentation1.38344553
64MP0005464_abnormal_platelet_physiology1.38272854
65MP0005389_reproductive_system_phenotype1.36884219
66MP0009333_abnormal_splenocyte_physiolog1.35611292
67MP0001730_embryonic_growth_arrest1.35120782
68MP0000313_abnormal_cell_death1.34622929
69MP0009046_muscle_twitch1.34052886
70MP0003436_decreased_susceptibility_to1.32518780
71MP0002736_abnormal_nociception_after1.26669496
72MP0003646_muscle_fatigue1.25307995
73MP0001929_abnormal_gametogenesis1.25105995
74MP0003186_abnormal_redox_activity1.25086416
75MP0002163_abnormal_gland_morphology1.24800528
76MP0001853_heart_inflammation1.20841559
77MP0006054_spinal_hemorrhage1.19318042
78MP0004142_abnormal_muscle_tone1.15786900
79MP0001485_abnormal_pinna_reflex1.15327583
80MP0002148_abnormal_hypersensitivity_rea1.15185773
81MP0010155_abnormal_intestine_physiology1.14359305
82MP0005000_abnormal_immune_tolerance1.14262765
83MP0002419_abnormal_innate_immunity1.12457525
84MP0001145_abnormal_male_reproductive1.11423046
85MP0002234_abnormal_pharynx_morphology1.11181656
86MP0000653_abnormal_sex_gland1.09739429
87MP0001188_hyperpigmentation1.09365836
88MP0003195_calcinosis1.09291556
89MP0003567_abnormal_fetal_cardiomyocyte1.09261699
90MP0001764_abnormal_homeostasis1.09043105
91MP0001984_abnormal_olfaction1.08977866
92MP0003787_abnormal_imprinting1.08355815
93MP0006276_abnormal_autonomic_nervous1.07454405
94MP0005408_hypopigmentation1.06940166
95MP0002405_respiratory_system_inflammati1.05427910
96MP0008877_abnormal_DNA_methylation1.03661322
97MP0003123_paternal_imprinting1.03205872
98MP0000858_altered_metastatic_potential1.03088049
99MP0008872_abnormal_physiological_respon1.01817352
100MP0008789_abnormal_olfactory_epithelium1.00997249
101MP0004215_abnormal_myocardial_fiber0.99782229
102MP0001919_abnormal_reproductive_system0.99746569
103MP0010368_abnormal_lymphatic_system0.98495909
104MP0003172_abnormal_lysosome_physiology0.98488900
105MP0005387_immune_system_phenotype0.98398978
106MP0001790_abnormal_immune_system0.98398978
107MP0005646_abnormal_pituitary_gland0.97751697
108MP0001697_abnormal_embryo_size0.97370992
109MP0003890_abnormal_embryonic-extraembry0.96876740
110MP0005379_endocrine/exocrine_gland_phen0.96675071
111MP0001968_abnormal_touch/_nociception0.96561557
112MP0002080_prenatal_lethality0.94470905
113MP0003698_abnormal_male_reproductive0.91924408
114MP0006036_abnormal_mitochondrial_physio0.90600135
115MP0001845_abnormal_inflammatory_respons0.90181104
116MP0002751_abnormal_autonomic_nervous0.90054460
117MP0000647_abnormal_sebaceous_gland0.88438371
118MP0004197_abnormal_fetal_growth/weight/0.88165557
119MP0001293_anophthalmia0.87831090
120MP0000427_abnormal_hair_cycle0.86331739
121MP0002653_abnormal_ependyma_morphology0.84276408
122MP0002638_abnormal_pupillary_reflex0.84045748
123MP0010307_abnormal_tumor_latency0.83357248
124MP0002086_abnormal_extraembryonic_tissu0.83339258
125MP0005195_abnormal_posterior_eye0.83204692
126MP0005332_abnormal_amino_acid0.83176965
127MP0002928_abnormal_bile_duct0.83087401
128MP0001286_abnormal_eye_development0.82835379
129MP0005391_vision/eye_phenotype0.81273049
130MP0000477_abnormal_intestine_morphology0.81038688
131MP0009278_abnormal_bone_marrow0.80865643
132MP0005380_embryogenesis_phenotype0.80495920
133MP0001672_abnormal_embryogenesis/_devel0.80495920
134MP0005187_abnormal_penis_morphology0.80401726
135MP0003937_abnormal_limbs/digits/tail_de0.79316030
136MP0002277_abnormal_respiratory_mucosa0.78667359
137MP0005220_abnormal_exocrine_pancreas0.78132363
138MP0002075_abnormal_coat/hair_pigmentati0.77682470
139MP0001119_abnormal_female_reproductive0.77567586
140MP0003943_abnormal_hepatobiliary_system0.77500106
141MP0004133_heterotaxia0.76815897
142MP0002877_abnormal_melanocyte_morpholog0.75484894
143MP0003880_abnormal_central_pattern0.75376134
144MP0008469_abnormal_protein_level0.73949256
145MP0002210_abnormal_sex_determination0.73698800
146MP0008995_early_reproductive_senescence0.73585133
147MP0005266_abnormal_metabolism0.73251560
148MP0003984_embryonic_growth_retardation0.71896279
149MP0002090_abnormal_vision0.71489936
150MP0005023_abnormal_wound_healing0.70884598
151MP0000358_abnormal_cell_content/0.70259046
152MP0003303_peritoneal_inflammation0.69936928
153MP0003866_abnormal_defecation0.69216843
154MP0003121_genomic_imprinting0.69111355
155MP0004885_abnormal_endolymph0.68379904
156MP0002088_abnormal_embryonic_growth/wei0.67399119
157MP0001243_abnormal_dermal_layer0.67038014
158MP0003941_abnormal_skin_development0.66018272
159MP0003221_abnormal_cardiomyocyte_apopto0.65274679
160MP0000598_abnormal_liver_morphology0.65049674
161MP0009697_abnormal_copulation0.65007616
162MP0002938_white_spotting0.64730964
163MP0001324_abnormal_eye_pigmentation0.63768909
164MP0008875_abnormal_xenobiotic_pharmacok0.63558974
165MP0002272_abnormal_nervous_system0.63484312

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)4.60757463
2Reticulocytopenia (HP:0001896)4.51339200
3Colon cancer (HP:0003003)4.50899956
4Abnormal number of erythroid precursors (HP:0012131)4.49052913
5Abnormality of cells of the erythroid lineage (HP:0012130)4.43297377
6Birth length less than 3rd percentile (HP:0003561)4.19276462
7Aplastic anemia (HP:0001915)3.94337011
8Acute necrotizing encephalopathy (HP:0006965)3.87016876
9Reduced antithrombin III activity (HP:0001976)3.80767501
10Thrombocytosis (HP:0001894)3.71854255
11Increased hepatocellular lipid droplets (HP:0006565)3.70384961
12Abnormal mitochondria in muscle tissue (HP:0008316)3.59245701
13Lipid accumulation in hepatocytes (HP:0006561)3.58426846
14IgM deficiency (HP:0002850)3.56342106
15Mitochondrial inheritance (HP:0001427)3.54419374
16Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.52055713
17Abnormal protein N-linked glycosylation (HP:0012347)3.52055713
18Abnormal protein glycosylation (HP:0012346)3.52055713
19Abnormal glycosylation (HP:0012345)3.52055713
20Increased CSF lactate (HP:0002490)3.47621052
21Progressive macrocephaly (HP:0004481)3.45854360
22Acute encephalopathy (HP:0006846)3.45050991
23Poikiloderma (HP:0001029)3.36529915
24Pancreatic cysts (HP:0001737)3.18837119
25Elevated erythrocyte sedimentation rate (HP:0003565)3.09028532
26Pallor (HP:0000980)3.06491790
27Pancreatic fibrosis (HP:0100732)3.02366154
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.01306421
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.01306421
30Petechiae (HP:0000967)2.96737749
31Chromsome breakage (HP:0040012)2.90137506
32Panhypogammaglobulinemia (HP:0003139)2.84409690
33Methylmalonic acidemia (HP:0002912)2.83515969
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.81579030
35Renal Fanconi syndrome (HP:0001994)2.80326534
36Abnormality of the ileum (HP:0001549)2.80204134
37Myositis (HP:0100614)2.78308673
38Abnormality of midbrain morphology (HP:0002418)2.74777799
39Molar tooth sign on MRI (HP:0002419)2.74777799
40True hermaphroditism (HP:0010459)2.67094496
41Cerebral edema (HP:0002181)2.62647636
42Abnormality of T cell physiology (HP:0011840)2.61818180
43Macrocytic anemia (HP:0001972)2.59710191
44Increased intramyocellular lipid droplets (HP:0012240)2.55529521
45Medulloblastoma (HP:0002885)2.55261134
46Myelodysplasia (HP:0002863)2.48459260
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.47675516
48Absent thumb (HP:0009777)2.44710036
49Methylmalonic aciduria (HP:0012120)2.41306969
50Abnormality of DNA repair (HP:0003254)2.41265436
51Nephronophthisis (HP:0000090)2.41071517
52Abnormality of T cells (HP:0002843)2.39588829
53Entropion (HP:0000621)2.39543194
5411 pairs of ribs (HP:0000878)2.39119082
55Hepatocellular necrosis (HP:0001404)2.36034944
56Recurrent viral infections (HP:0004429)2.35628751
57Breast hypoplasia (HP:0003187)2.35285260
58Abnormality of the anterior horn cell (HP:0006802)2.34998919
59Degeneration of anterior horn cells (HP:0002398)2.34998919
60Abnormality of the labia minora (HP:0012880)2.34574707
61Ragged-red muscle fibers (HP:0003200)2.34176667
62Abnormality of the renal cortex (HP:0011035)2.34133057
63Pancytopenia (HP:0001876)2.33527002
64Microvesicular hepatic steatosis (HP:0001414)2.33046867
65Prolonged bleeding time (HP:0003010)2.32672973
66Lactic acidosis (HP:0003128)2.29722859
67Volvulus (HP:0002580)2.29310387
68Abnormality of alanine metabolism (HP:0010916)2.25299810
69Hyperalaninemia (HP:0003348)2.25299810
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25299810
71Exertional dyspnea (HP:0002875)2.25203359
72Lymphoma (HP:0002665)2.22378625
73Hypoplasia of the pons (HP:0012110)2.21541703
74Cerebellar dysplasia (HP:0007033)2.20000709
75Pendular nystagmus (HP:0012043)2.19697555
76Chronic otitis media (HP:0000389)2.19638727
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.18523872
78Abnormality of the pons (HP:0007361)2.18397783
79Cutaneous melanoma (HP:0012056)2.18244070
80Congenital stationary night blindness (HP:0007642)2.17743722
81Abnormality of the renal medulla (HP:0100957)2.17251908
82Oral leukoplakia (HP:0002745)2.16742726
83Septo-optic dysplasia (HP:0100842)2.16340431
84Acute myeloid leukemia (HP:0004808)2.16317478
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15942108
86Abnormality of chromosome stability (HP:0003220)2.15823590
87IgG deficiency (HP:0004315)2.15186135
88Basal cell carcinoma (HP:0002671)2.11156155
89Renal cortical cysts (HP:0000803)2.10407594
90Type 2 muscle fiber atrophy (HP:0003554)2.09873419
91Duodenal stenosis (HP:0100867)2.09666085
92Small intestinal stenosis (HP:0012848)2.09666085
93Increased muscle lipid content (HP:0009058)2.09510606
94Hepatic necrosis (HP:0002605)2.09346142
95Ectopic kidney (HP:0000086)2.09338291
96Abolished electroretinogram (ERG) (HP:0000550)2.07223064
97Sloping forehead (HP:0000340)2.06348100
98Optic disc pallor (HP:0000543)2.05986273
99Abnormality of the prostate (HP:0008775)2.04501886
100B lymphocytopenia (HP:0010976)2.03947287
101Abnormality of B cell number (HP:0010975)2.03947287
102Muscle fiber atrophy (HP:0100295)2.02172749
103Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00874829
104Clubbing of toes (HP:0100760)2.00523143
105Optic nerve coloboma (HP:0000588)1.99697553
106Bone marrow hypocellularity (HP:0005528)1.99630073
107Agnosia (HP:0010524)1.98612109
108Acute lymphatic leukemia (HP:0006721)1.98585279
109Recurrent bronchitis (HP:0002837)1.96818755
110Premature graying of hair (HP:0002216)1.96741427
111Epistaxis (HP:0000421)1.95412777
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95376609
113Triphalangeal thumb (HP:0001199)1.94519994
114Selective tooth agenesis (HP:0001592)1.94196027
115Severe visual impairment (HP:0001141)1.94135700
116Exercise intolerance (HP:0003546)1.93125239
117Carpal bone hypoplasia (HP:0001498)1.92962239
118Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92621138
119Medial flaring of the eyebrow (HP:0010747)1.92385967
120Increased serum lactate (HP:0002151)1.92318350
121Abnormality of methionine metabolism (HP:0010901)1.92260817
122Neoplasm of the pancreas (HP:0002894)1.90929668
123Microretrognathia (HP:0000308)1.89991594
124Neoplasm of the adrenal cortex (HP:0100641)1.89963023
125Slender long bone (HP:0003100)1.89890902
126Abnormality of the duodenum (HP:0002246)1.89709979
1273-Methylglutaconic aciduria (HP:0003535)1.88904440
128Abnormality of the renal collecting system (HP:0004742)1.88714653
129Patellar aplasia (HP:0006443)1.88386351
130Leukodystrophy (HP:0002415)1.88271342
131Pustule (HP:0200039)1.87530848
132Neoplasm of the oral cavity (HP:0100649)1.86424870
133Respiratory failure (HP:0002878)1.85782587
134Congenital, generalized hypertrichosis (HP:0004540)1.84676107
135Duplicated collecting system (HP:0000081)1.84238323
136Lethargy (HP:0001254)1.83573255
137Abnormality of vitamin B metabolism (HP:0004340)1.83525885
138Abnormality of homocysteine metabolism (HP:0010919)1.83321047
139Homocystinuria (HP:0002156)1.83321047
140Respiratory difficulties (HP:0002880)1.82458358
141Recurrent fungal infections (HP:0002841)1.82148269
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.81638312
143Lymphopenia (HP:0001888)1.81414728
144Type II lissencephaly (HP:0007260)1.81312668
145Sclerocornea (HP:0000647)1.80798320
146Short tibia (HP:0005736)1.80748050
147Abnormality of the preputium (HP:0100587)1.79670070
148Abnormality of renal resorption (HP:0011038)1.78715418
149Bile duct proliferation (HP:0001408)1.77851100
150Abnormal biliary tract physiology (HP:0012439)1.77851100
151Abnormality of cells of the lymphoid lineage (HP:0012140)1.76013414
152Abnormality of serum amino acid levels (HP:0003112)1.75747808
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75694398
154Atresia of the external auditory canal (HP:0000413)1.74673468
155Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74663934
156Abnormality of reticulocytes (HP:0004312)1.74552940
157Amaurosis fugax (HP:0100576)1.74221243
158Recurrent abscess formation (HP:0002722)1.72605333
159Abnormality of the columella (HP:0009929)1.71242956
160Self-mutilation (HP:0000742)1.70196542
161Granulocytopenia (HP:0001913)1.69705003
162Chronic mucocutaneous candidiasis (HP:0002728)1.69364631
163Recurrent cutaneous fungal infections (HP:0011370)1.69364631
164Meckel diverticulum (HP:0002245)1.68835180
165Spontaneous hematomas (HP:0007420)1.68160325
166Microcytic anemia (HP:0001935)1.67970728
167Neoplasm of the colon (HP:0100273)1.67741488
168Viral hepatitis (HP:0006562)1.67138415
169Neoplasm of the adrenal gland (HP:0100631)1.66988868
170Aplasia/Hypoplasia of the patella (HP:0006498)1.66959850
171Rectovaginal fistula (HP:0000143)1.66846999
172Rectal fistula (HP:0100590)1.66846999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK23.39126048
2EIF2AK13.20111014
3WEE13.05360213
4CAMKK22.93987311
5FRK2.87132366
6FLT32.75388952
7MAP4K12.69826113
8KIT2.60245384
9NUAK12.38163084
10MAP4K22.26337186
11BMPR1B2.25079052
12STK162.14323043
13CAMK1D2.06214868
14SRPK12.02173262
15CDC71.96575298
16EEF2K1.93082025
17VRK21.91923568
18ACVR1B1.90687468
19PLK41.89250504
20NEK11.88676377
21WNK31.82770837
22DYRK31.82144446
23VRK11.81405124
24BUB11.76977255
25NME21.73709839
26PBK1.71258301
27BTK1.70069701
28PIM21.67776572
29MARK31.59236952
30NME11.58835470
31MST41.58167459
32TRIM281.57224002
33PASK1.57181398
34TAOK31.56378849
35CDK71.53813718
36TXK1.52836500
37CDK81.52683424
38RPS6KB21.52262761
39TGFBR11.52179429
40SCYL21.47234739
41TEC1.46576112
42BRSK11.44675756
43RPS6KA41.44651964
44EIF2AK31.43861745
45TAF11.40401555
46ATR1.39445292
47MKNK11.39390336
48TSSK61.38415458
49JAK31.33490889
50NEK21.33144362
51LRRK21.28150661
52PKN21.27137761
53TYK21.25563466
54IRAK41.23071850
55CSF1R1.15464603
56NLK1.14767329
57TESK21.12344891
58ZAP701.11132164
59INSRR1.09561091
60STK101.09035338
61TNIK1.05916341
62GRK11.05107139
63CHEK21.04809013
64CAMK1G1.04463090
65PIM11.03980726
66RAF11.03878740
67KDR1.03809462
68PLK11.03519016
69TLK10.98588720
70PNCK0.96480924
71ERBB30.94984644
72OXSR10.94827056
73MAP3K100.93746256
74EIF2AK20.90572983
75CSNK1G10.90395908
76PLK20.90331395
77ATM0.88942441
78TTK0.88098447
79AURKB0.86624615
80STK390.85219488
81CCNB10.84923045
82ADRBK20.84754282
83TBK10.82796477
84IKBKE0.81616965
85ERN10.80448045
86CDK40.80423387
87TNK20.80240557
88STK40.76244979
89LYN0.75924075
90CLK10.75874783
91SYK0.75700095
92BCKDK0.75632893
93PLK30.74788818
94FGFR20.73521527
95STK30.71028344
96MATK0.70307663
97MAP3K80.70115446
98GRK60.69803148
99WNK40.68779010
100PAK40.68451860
101ZAK0.68442897
102CDK120.67881359
103CSNK1G20.65749563
104LCK0.65638671
105FES0.65499375
106BLK0.64062782
107PINK10.63517040
108CDK30.59132840
109TIE10.58772100
110ARAF0.57949629
111MKNK20.57839530
112CAMKK10.57790076
113CHEK10.57466324
114RPS6KA50.57034499
115IKBKB0.56612556
116MAPKAPK50.55447396
117PDK20.54406415
118CSNK1A1L0.52389694
119DYRK20.52158765
120MAPK130.51581865
121CSNK2A10.50397060
122CAMK40.50149728
123ILK0.50124591
124CSNK1G30.49749194
125TGFBR20.49726861
126ITK0.47493213
127MAP3K40.47041133
128CSNK1E0.46760755
129YES10.46072960
130BRD40.45699395
131STK38L0.44645231
132PRKCG0.43371412
133MAP3K130.42513398
134TRPM70.42176871
135CDK190.41939369
136MAPKAPK30.41843384
137BCR0.39957799
138CSNK1A10.39783903
139PRKCE0.39141938
140CAMK10.38826507
141RPS6KA60.38782109
142BMPR20.37917764
143CDK10.37870597
144CSNK2A20.37691052
145PRKDC0.37085340
146CDK20.37004508
147AURKA0.34962774
148ERBB40.33279945
149PRKCI0.31427027
150OBSCN0.30877978

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.46469523
2Mismatch repair_Homo sapiens_hsa034304.50198003
3Ribosome_Homo sapiens_hsa030104.00647513
4Base excision repair_Homo sapiens_hsa034103.30691046
5Oxidative phosphorylation_Homo sapiens_hsa001903.17735232
6Homologous recombination_Homo sapiens_hsa034403.14299665
7Nucleotide excision repair_Homo sapiens_hsa034203.09750483
8RNA polymerase_Homo sapiens_hsa030202.79573967
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.78605586
10Spliceosome_Homo sapiens_hsa030402.75849747
11Proteasome_Homo sapiens_hsa030502.61255417
12Pyrimidine metabolism_Homo sapiens_hsa002402.49261598
13Non-homologous end-joining_Homo sapiens_hsa034502.33274187
14Cell cycle_Homo sapiens_hsa041102.25990935
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20227617
16One carbon pool by folate_Homo sapiens_hsa006702.15332234
17RNA transport_Homo sapiens_hsa030132.09591759
18Fanconi anemia pathway_Homo sapiens_hsa034601.90912993
19Primary immunodeficiency_Homo sapiens_hsa053401.78074486
20RNA degradation_Homo sapiens_hsa030181.73940709
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68291236
22Alzheimers disease_Homo sapiens_hsa050101.66386540
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47316491
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47184700
25Propanoate metabolism_Homo sapiens_hsa006401.43883187
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36166361
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.36082238
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34998933
29Purine metabolism_Homo sapiens_hsa002301.34473808
30p53 signaling pathway_Homo sapiens_hsa041151.29939571
31Selenocompound metabolism_Homo sapiens_hsa004501.29470111
32Herpes simplex infection_Homo sapiens_hsa051681.20712569
33Cardiac muscle contraction_Homo sapiens_hsa042601.16618788
34Antigen processing and presentation_Homo sapiens_hsa046121.15968200
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15534337
36Basal transcription factors_Homo sapiens_hsa030221.14677222
37Folate biosynthesis_Homo sapiens_hsa007901.05907820
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02178394
39Phototransduction_Homo sapiens_hsa047441.00097496
40Butanoate metabolism_Homo sapiens_hsa006500.98598862
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97335891
42Measles_Homo sapiens_hsa051620.97292468
43N-Glycan biosynthesis_Homo sapiens_hsa005100.96525149
44Systemic lupus erythematosus_Homo sapiens_hsa053220.89702315
45Protein export_Homo sapiens_hsa030600.88150810
46Nitrogen metabolism_Homo sapiens_hsa009100.84526758
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84476495
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83203450
49Epstein-Barr virus infection_Homo sapiens_hsa051690.82765147
50Fatty acid elongation_Homo sapiens_hsa000620.82737024
51Pentose phosphate pathway_Homo sapiens_hsa000300.80294033
52Linoleic acid metabolism_Homo sapiens_hsa005910.78087643
53Thyroid cancer_Homo sapiens_hsa052160.77148264
54Peroxisome_Homo sapiens_hsa041460.77098224
55Viral carcinogenesis_Homo sapiens_hsa052030.76469832
56Sulfur relay system_Homo sapiens_hsa041220.76299744
57Legionellosis_Homo sapiens_hsa051340.75126233
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.75026905
59Hematopoietic cell lineage_Homo sapiens_hsa046400.74692697
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73957276
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71548950
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71221851
63Pyruvate metabolism_Homo sapiens_hsa006200.71174845
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70345698
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70202648
66Caffeine metabolism_Homo sapiens_hsa002320.68938597
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.68267331
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68042570
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.67893627
70Acute myeloid leukemia_Homo sapiens_hsa052210.65396533
71Biosynthesis of amino acids_Homo sapiens_hsa012300.63969255
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62530613
73Tryptophan metabolism_Homo sapiens_hsa003800.62135932
74Regulation of autophagy_Homo sapiens_hsa041400.61577952
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.61364524
76mRNA surveillance pathway_Homo sapiens_hsa030150.60305689
77Vitamin B6 metabolism_Homo sapiens_hsa007500.59499993
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57982337
79HTLV-I infection_Homo sapiens_hsa051660.57776503
80Oocyte meiosis_Homo sapiens_hsa041140.57132453
81Leishmaniasis_Homo sapiens_hsa051400.57005132
82Galactose metabolism_Homo sapiens_hsa000520.56999597
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.56578331
84Hepatitis B_Homo sapiens_hsa051610.55811244
85Steroid biosynthesis_Homo sapiens_hsa001000.55474732
86Glutathione metabolism_Homo sapiens_hsa004800.55042442
87Olfactory transduction_Homo sapiens_hsa047400.51829486
88Ether lipid metabolism_Homo sapiens_hsa005650.51215609
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49629865
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49619665
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48642500
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48415276
93Taste transduction_Homo sapiens_hsa047420.47669841
94Influenza A_Homo sapiens_hsa051640.47282486
95Huntingtons disease_Homo sapiens_hsa050160.46772152
96B cell receptor signaling pathway_Homo sapiens_hsa046620.46463202
97Apoptosis_Homo sapiens_hsa042100.43283478
98Type I diabetes mellitus_Homo sapiens_hsa049400.42847008
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.42465851
100Other glycan degradation_Homo sapiens_hsa005110.42237961
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41548644
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41510017
103Shigellosis_Homo sapiens_hsa051310.39988751
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39791252
105Nicotine addiction_Homo sapiens_hsa050330.39215946
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37223797
107Parkinsons disease_Homo sapiens_hsa050120.36955115
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35566532
109Carbon metabolism_Homo sapiens_hsa012000.33273967
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31738197
111Chemical carcinogenesis_Homo sapiens_hsa052040.30977758
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30846647
113beta-Alanine metabolism_Homo sapiens_hsa004100.29608805
114Metabolic pathways_Homo sapiens_hsa011000.27926623
115Arachidonic acid metabolism_Homo sapiens_hsa005900.27599703
116Colorectal cancer_Homo sapiens_hsa052100.27464208
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26784109
118Fructose and mannose metabolism_Homo sapiens_hsa000510.26320140
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26100673
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25050956
121Vitamin digestion and absorption_Homo sapiens_hsa049770.23895367
122Chronic myeloid leukemia_Homo sapiens_hsa052200.23590615
123MicroRNAs in cancer_Homo sapiens_hsa052060.23468757
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23274541
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23102037
126Platelet activation_Homo sapiens_hsa046110.22691867
127Lysine degradation_Homo sapiens_hsa003100.22583927
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22443248
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21167115
130Fatty acid metabolism_Homo sapiens_hsa012120.19907320
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.19876927
132Asthma_Homo sapiens_hsa053100.19492355
133Small cell lung cancer_Homo sapiens_hsa052220.18721549
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18124596
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17977261
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.17550832
137Retinol metabolism_Homo sapiens_hsa008300.17419244
138Allograft rejection_Homo sapiens_hsa053300.16759899
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16188324
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.16159831
141Autoimmune thyroid disease_Homo sapiens_hsa053200.15200585
142Sulfur metabolism_Homo sapiens_hsa009200.15006219
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.14886657
144Alcoholism_Homo sapiens_hsa050340.14853351

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