THUMPD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.51477965
2protein localization to kinetochore (GO:0034501)5.02749463
3ribosomal small subunit assembly (GO:0000028)4.68964890
4formation of translation preinitiation complex (GO:0001731)4.62226178
5DNA double-strand break processing (GO:0000729)4.60756175
6DNA strand elongation involved in DNA replication (GO:0006271)4.55260655
7DNA replication initiation (GO:0006270)4.53972355
8maturation of SSU-rRNA (GO:0030490)4.40678892
9DNA strand elongation (GO:0022616)4.32072957
10nucleobase biosynthetic process (GO:0046112)4.27460346
11replication fork processing (GO:0031297)4.20958618
12negative regulation of DNA-dependent DNA replication (GO:2000104)4.20169253
13ribosome biogenesis (GO:0042254)4.18363464
14telomere maintenance via semi-conservative replication (GO:0032201)4.14339447
15purine nucleobase biosynthetic process (GO:0009113)4.09474209
16protein localization to chromosome, centromeric region (GO:0071459)4.03630913
17ribosome assembly (GO:0042255)4.02472278
18IMP biosynthetic process (GO:0006188)4.00748807
19mitotic nuclear envelope disassembly (GO:0007077)3.97446151
20viral transcription (GO:0019083)3.95572969
21translational termination (GO:0006415)3.91498179
22folic acid-containing compound biosynthetic process (GO:0009396)3.90069503
23mitotic metaphase plate congression (GO:0007080)3.88224782
24ribonucleoprotein complex biogenesis (GO:0022613)3.82405265
25nuclear pore organization (GO:0006999)3.79106466
26nuclear envelope disassembly (GO:0051081)3.78899285
27membrane disassembly (GO:0030397)3.78899285
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77314937
29mitotic recombination (GO:0006312)3.77235803
30somatic hypermutation of immunoglobulin genes (GO:0016446)3.75312032
31somatic diversification of immune receptors via somatic mutation (GO:0002566)3.75312032
32DNA replication checkpoint (GO:0000076)3.73352713
33IMP metabolic process (GO:0046040)3.71254345
34translational elongation (GO:0006414)3.70909689
35regulation of meiosis I (GO:0060631)3.69903511
36regulation of mitotic spindle checkpoint (GO:1903504)3.69445386
37regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.69445386
38CENP-A containing nucleosome assembly (GO:0034080)3.68953304
39DNA replication-dependent nucleosome assembly (GO:0006335)3.67020009
40DNA replication-dependent nucleosome organization (GO:0034723)3.67020009
41translational initiation (GO:0006413)3.65094850
42telomere maintenance via recombination (GO:0000722)3.64682067
43chromatin remodeling at centromere (GO:0031055)3.63906074
44DNA replication-independent nucleosome organization (GO:0034724)3.63663064
45DNA replication-independent nucleosome assembly (GO:0006336)3.63663064
46RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.60405569
47nuclear pore complex assembly (GO:0051292)3.57558375
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55039279
49lactate metabolic process (GO:0006089)3.54467239
50ribosomal small subunit biogenesis (GO:0042274)3.53987276
51protein prenylation (GO:0018342)3.52391736
52prenylation (GO:0097354)3.52391736
53DNA deamination (GO:0045006)3.51790720
54attachment of spindle microtubules to kinetochore (GO:0008608)3.48544120
55DNA duplex unwinding (GO:0032508)3.47886118
56telomere maintenance via telomere lengthening (GO:0010833)3.47526835
57DNA geometric change (GO:0032392)3.44395823
58mitotic chromosome condensation (GO:0007076)3.43779062
59ribosomal large subunit biogenesis (GO:0042273)3.43316338
60protein K11-linked deubiquitination (GO:0035871)3.42992284
61spliceosomal snRNP assembly (GO:0000387)3.41984195
62rRNA processing (GO:0006364)3.39858340
63water-soluble vitamin biosynthetic process (GO:0042364)3.39280837
64maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.37091705
65synapsis (GO:0007129)3.37068943
66metaphase plate congression (GO:0051310)3.36711230
67negative regulation of translation, ncRNA-mediated (GO:0040033)3.36669491
68regulation of translation, ncRNA-mediated (GO:0045974)3.36669491
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.36669491
70establishment of integrated proviral latency (GO:0075713)3.35871927
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.34381631
72response to pheromone (GO:0019236)3.32068259
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.29261005
74rRNA metabolic process (GO:0016072)3.28875517
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26456873
76peptidyl-arginine omega-N-methylation (GO:0035247)3.25824283
77resolution of meiotic recombination intermediates (GO:0000712)3.24086149
78kinetochore organization (GO:0051383)3.21666186
79regulation of centriole replication (GO:0046599)3.21463821
80recombinational repair (GO:0000725)3.20526371
81double-strand break repair via homologous recombination (GO:0000724)3.20007343
82cellular protein complex disassembly (GO:0043624)3.18278594
83cotranslational protein targeting to membrane (GO:0006613)3.17900519
84pseudouridine synthesis (GO:0001522)3.17572122
85histone exchange (GO:0043486)3.16719897
86protein targeting to ER (GO:0045047)3.16587403
87histone H2A acetylation (GO:0043968)3.16084143
88ncRNA 3-end processing (GO:0043628)3.15062510
89regulation of spindle organization (GO:0090224)3.15023378
90regulation of glucokinase activity (GO:0033131)3.13374585
91regulation of hexokinase activity (GO:1903299)3.13374585
92negative regulation of histone methylation (GO:0031061)3.10378138
93viral life cycle (GO:0019058)3.08274962
94RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.08193516
95mRNA splicing, via spliceosome (GO:0000398)3.08193516
96RNA splicing, via transesterification reactions (GO:0000375)3.08177384
97mitotic sister chromatid cohesion (GO:0007064)3.07994953
98negative regulation of RNA splicing (GO:0033119)3.07816325
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07215928
100respiratory chain complex IV assembly (GO:0008535)3.05867719
101somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.04149380
102somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.04149380
103isotype switching (GO:0045190)3.04149380
104viral mRNA export from host cell nucleus (GO:0046784)3.03055688
105protein localization to endoplasmic reticulum (GO:0070972)3.02836034
106L-fucose catabolic process (GO:0042355)3.02083742
107fucose catabolic process (GO:0019317)3.02083742
108L-fucose metabolic process (GO:0042354)3.02083742
109positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00996718
110positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00996718
111positive regulation of mitotic sister chromatid separation (GO:1901970)3.00996718
112establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00831505
113regulation of DNA endoreduplication (GO:0032875)3.00598803
114proteasome assembly (GO:0043248)3.00251810
115cullin deneddylation (GO:0010388)3.00064904
116protein localization to chromosome (GO:0034502)2.99197994
117protein complex disassembly (GO:0043241)2.99183775
118establishment of chromosome localization (GO:0051303)2.99174732
119nuclear-transcribed mRNA catabolic process (GO:0000956)2.98732678
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.97409441
121regulation of nuclear cell cycle DNA replication (GO:0033262)2.96427397
122protein K6-linked ubiquitination (GO:0085020)2.95852177
123snRNA processing (GO:0016180)2.95806056
124signal peptide processing (GO:0006465)2.95576042
125chromatin assembly or disassembly (GO:0006333)2.94830068
126nuclear envelope organization (GO:0006998)2.93870354
127histone arginine methylation (GO:0034969)2.93118557
128tRNA aminoacylation for protein translation (GO:0006418)2.92325623
129regulation of histone H3-K9 methylation (GO:0051570)2.92168408
130spindle checkpoint (GO:0031577)2.91601015
131protein deneddylation (GO:0000338)2.91318747
132regulation of translational termination (GO:0006449)2.89750299
133transcription-coupled nucleotide-excision repair (GO:0006283)2.89311598
134spliceosomal complex assembly (GO:0000245)2.88739909
135regulation of double-strand break repair via homologous recombination (GO:0010569)2.88671596
136sister chromatid segregation (GO:0000819)2.88375677
137negative regulation of chromosome segregation (GO:0051985)2.88362796
138positive regulation of histone H3-K4 methylation (GO:0051571)2.88240596
139peptidyl-arginine methylation (GO:0018216)2.86973803
140peptidyl-arginine N-methylation (GO:0035246)2.86973803
141negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86532670
142kinetochore assembly (GO:0051382)2.83393304
143photoreceptor cell maintenance (GO:0045494)2.80966885
144neural tube formation (GO:0001841)2.79898590
145centriole replication (GO:0007099)2.77875665
146platelet dense granule organization (GO:0060155)2.76559274
147branched-chain amino acid catabolic process (GO:0009083)2.75525995
148intraciliary transport (GO:0042073)2.75152925
149response to X-ray (GO:0010165)2.73782023
150intra-S DNA damage checkpoint (GO:0031573)2.71973586
151regulation of helicase activity (GO:0051095)2.69487557
152positive regulation of protein autophosphorylation (GO:0031954)2.69157853
153keratinocyte development (GO:0003334)2.68603774
154kidney morphogenesis (GO:0060993)2.66905512
155histone mRNA catabolic process (GO:0071044)2.65669192
156double-strand break repair via nonhomologous end joining (GO:0006303)2.65573330
157non-recombinational repair (GO:0000726)2.65573330
158detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64757035
159telomere maintenance via telomerase (GO:0007004)2.62844030
160negative regulation of DNA recombination (GO:0045910)2.62722041
161DNA catabolic process, exonucleolytic (GO:0000738)2.62664598
162exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61046314
163establishment of protein localization to Golgi (GO:0072600)2.59375857
164inositol phosphate catabolic process (GO:0071545)2.57614959
165polyol catabolic process (GO:0046174)2.56807820
166nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.56614082
167tryptophan catabolic process (GO:0006569)2.55148610
168indole-containing compound catabolic process (GO:0042436)2.55148610
169indolalkylamine catabolic process (GO:0046218)2.55148610
170double-strand break repair (GO:0006302)2.54287633
171regulation of centrosome duplication (GO:0010824)2.53842920
172cytochrome complex assembly (GO:0017004)2.53823954
173retinal cone cell development (GO:0046549)2.52379731
174piRNA metabolic process (GO:0034587)2.51764994
175indolalkylamine metabolic process (GO:0006586)2.51422953
176reciprocal DNA recombination (GO:0035825)2.50920940
177reciprocal meiotic recombination (GO:0007131)2.50920940
178regulation of telomere maintenance (GO:0032204)2.50731737
179histone mRNA metabolic process (GO:0008334)2.49979776
180mitotic spindle checkpoint (GO:0071174)2.49748830
181postreplication repair (GO:0006301)2.49548096
182S-adenosylmethionine metabolic process (GO:0046500)2.48631970
183monoubiquitinated protein deubiquitination (GO:0035520)2.48520106
184maturation of 5.8S rRNA (GO:0000460)2.47892974
185cilium morphogenesis (GO:0060271)2.45417628
186centrosome organization (GO:0051297)2.45119721
187sister chromatid cohesion (GO:0007062)2.45010137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55638502
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.72684100
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91189399
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.62395954
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44818056
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.25115821
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24687813
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95474484
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94800772
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91879919
11ZNF274_21170338_ChIP-Seq_K562_Hela2.85254949
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.84602339
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.83239207
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82306070
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72080922
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71946208
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.71790399
18VDR_22108803_ChIP-Seq_LS180_Human2.69908853
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63638575
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57720039
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.57186683
22XRN2_22483619_ChIP-Seq_HELA_Human2.56114568
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51882595
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.51604547
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.49365313
26GBX2_23144817_ChIP-Seq_PC3_Human2.43154818
27EWS_26573619_Chip-Seq_HEK293_Human2.40833623
28IGF1R_20145208_ChIP-Seq_DFB_Human2.38009367
29* VDR_23849224_ChIP-Seq_CD4+_Human2.32912851
30FUS_26573619_Chip-Seq_HEK293_Human2.31438519
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31040630
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28564426
33TAF15_26573619_Chip-Seq_HEK293_Human2.28062364
34P300_19829295_ChIP-Seq_ESCs_Human2.18221299
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12943777
36* FOXP3_21729870_ChIP-Seq_TREG_Human2.09618516
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09514658
38MYC_22102868_ChIP-Seq_BL_Human2.07294286
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04694116
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02464408
41GABP_19822575_ChIP-Seq_HepG2_Human2.01601310
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.01418089
43MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00900179
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98975579
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98573920
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97610922
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.97142759
48AR_21909140_ChIP-Seq_LNCAP_Human1.96062051
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.95734387
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94126107
51DCP1A_22483619_ChIP-Seq_HELA_Human1.91669757
52CIITA_25753668_ChIP-Seq_RAJI_Human1.91184350
53TTF2_22483619_ChIP-Seq_HELA_Human1.88334243
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88244433
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85071121
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.82208658
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80919046
58* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.80130703
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77518131
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73161931
61* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70907556
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.67006071
63* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65931093
64ER_23166858_ChIP-Seq_MCF-7_Human1.65456418
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.61592319
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60902173
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59728208
68ELK1_19687146_ChIP-ChIP_HELA_Human1.58559776
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54738291
70KDM5A_27292631_Chip-Seq_BREAST_Human1.54620681
71SMAD4_21799915_ChIP-Seq_A2780_Human1.54136907
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52182710
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51703309
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51394130
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50761067
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.48894402
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48800119
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47799124
79BCAT_22108803_ChIP-Seq_LS180_Human1.46577527
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46479585
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45864040
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44739283
83CBP_20019798_ChIP-Seq_JUKART_Human1.44676424
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44676424
85STAT3_23295773_ChIP-Seq_U87_Human1.41856862
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40512772
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.40024022
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39317146
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39315154
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.39031491
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38757064
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38737356
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38086547
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37291578
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36798723
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35944113
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.34709519
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33434470
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32945618
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32774583
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32678816
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31958481
103AR_25329375_ChIP-Seq_VCAP_Human1.31026194
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29255535
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.29185706
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28395366
107* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27593784
108TCF4_23295773_ChIP-Seq_U87_Human1.27112940
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26940469
110* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25973352
111TCF4_22108803_ChIP-Seq_LS180_Human1.25766475
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25543479
113NANOG_19829295_ChIP-Seq_ESCs_Human1.25533578
114SOX2_19829295_ChIP-Seq_ESCs_Human1.25533578
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24757636
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24258134
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24156104
118STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23822538
119P53_22387025_ChIP-Seq_ESCs_Mouse1.22167071
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22015063
121CDX2_22108803_ChIP-Seq_LS180_Human1.21182445
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21009984
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20836728
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20504632
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19569690
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18802629
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18709218
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17315442
129SMAD_19615063_ChIP-ChIP_OVARY_Human1.17018262
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16024621
131SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15796584
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15596333
133KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15587664
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.14472173
135GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14378240
136P300_18555785_Chip-Seq_ESCs_Mouse1.14282819
137E2F1_18555785_Chip-Seq_ESCs_Mouse1.13969740
138SRF_21415370_ChIP-Seq_HL-1_Mouse1.13388407
139OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13190478
140CMYC_18555785_Chip-Seq_ESCs_Mouse1.13013221
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11256666
142TFEB_21752829_ChIP-Seq_HELA_Human1.10774918
143SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10525111
144RUNX2_22187159_ChIP-Seq_PCA_Human1.10475780
145IRF1_19129219_ChIP-ChIP_H3396_Human1.10253241
146TP63_19390658_ChIP-ChIP_HaCaT_Human1.09621330
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09098695
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08999737
149STAT3_18555785_Chip-Seq_ESCs_Mouse1.08961752
150SMAD4_21741376_ChIP-Seq_EPCs_Human1.08063698
151TP53_22573176_ChIP-Seq_HFKS_Human1.07960390
152POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07078474
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07078474
154* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06455463
155FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05859404
156ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05267127
157VDR_21846776_ChIP-Seq_THP-1_Human1.04872670
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04470498
159* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04146341
160MYC_18940864_ChIP-ChIP_HL60_Human1.03190005
161NOTCH1_21737748_ChIP-Seq_TLL_Human1.03185078
162EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01930967
163SOX2_18555785_Chip-Seq_ESCs_Mouse1.00930450
164FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00693549
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99036132
166SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98344983
167PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92613081
168ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92276393
169SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91611317
170* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91251348
171ZNF263_19887448_ChIP-Seq_K562_Human0.89163058
172NANOG_21062744_ChIP-ChIP_HESCs_Human0.88410392
173ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87026307
174SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86972451
175CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85148792
176SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84972347
177SPI1_23547873_ChIP-Seq_NB4_Human0.82196050
178* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82121620
179DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81901645
180NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77784849
181PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77517459
182FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77222523
183TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76697274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.45854603
2MP0010094_abnormal_chromosome_stability4.73066468
3MP0004957_abnormal_blastocyst_morpholog4.67061899
4MP0003111_abnormal_nucleus_morphology4.34190866
5MP0008057_abnormal_DNA_replication4.28860124
6MP0003077_abnormal_cell_cycle3.94024614
7MP0008058_abnormal_DNA_repair3.75431793
8MP0003195_calcinosis3.12724269
9MP0003123_paternal_imprinting3.11777174
10MP0008007_abnormal_cellular_replicative2.92833486
11MP0010352_gastrointestinal_tract_polyps2.92574984
12MP0003787_abnormal_imprinting2.77203384
13MP0002396_abnormal_hematopoietic_system2.74620072
14MP0001730_embryonic_growth_arrest2.63131373
15MP0006072_abnormal_retinal_apoptosis2.59953250
16MP0008932_abnormal_embryonic_tissue2.58145048
17MP0002102_abnormal_ear_morphology2.37607189
18MP0000350_abnormal_cell_proliferation2.36746228
19MP0000569_abnormal_digit_pigmentation2.23056085
20MP0000372_irregular_coat_pigmentation2.10069703
21MP0002938_white_spotting2.00637869
22MP0001697_abnormal_embryo_size1.95936787
23MP0008877_abnormal_DNA_methylation1.90414856
24MP0005380_embryogenesis_phenotype1.87652450
25MP0001672_abnormal_embryogenesis/_devel1.87652450
26MP0003763_abnormal_thymus_physiology1.86213441
27MP0004808_abnormal_hematopoietic_stem1.84809008
28MP0005253_abnormal_eye_physiology1.84677944
29MP0002837_dystrophic_cardiac_calcinosis1.81398784
30MP0002080_prenatal_lethality1.80614141
31MP0000490_abnormal_crypts_of1.80355502
32MP0010307_abnormal_tumor_latency1.78989374
33MP0003786_premature_aging1.77954997
34MP0005551_abnormal_eye_electrophysiolog1.76943803
35MP0002084_abnormal_developmental_patter1.74940178
36MP0003567_abnormal_fetal_cardiomyocyte1.74593320
37MP0000427_abnormal_hair_cycle1.71281413
38MP0000516_abnormal_urinary_system1.69205015
39MP0005367_renal/urinary_system_phenotyp1.69205015
40MP0003984_embryonic_growth_retardation1.67519782
41MP0002085_abnormal_embryonic_tissue1.67418281
42MP0003121_genomic_imprinting1.65815534
43MP0002088_abnormal_embryonic_growth/wei1.64238677
44MP0004197_abnormal_fetal_growth/weight/1.64046872
45MP0002254_reproductive_system_inflammat1.58434875
46MP0003890_abnormal_embryonic-extraembry1.55015454
47MP0000313_abnormal_cell_death1.54527948
48MP0002019_abnormal_tumor_incidence1.51994362
49MP0002086_abnormal_extraembryonic_tissu1.50507267
50MP0001984_abnormal_olfaction1.43325841
51MP0001293_anophthalmia1.40166929
52MP0000703_abnormal_thymus_morphology1.38081115
53MP0005174_abnormal_tail_pigmentation1.34991002
54MP0009046_muscle_twitch1.34722989
55MP0005084_abnormal_gallbladder_morpholo1.34396562
56MP0005646_abnormal_pituitary_gland1.33871211
57MP0009333_abnormal_splenocyte_physiolog1.33741140
58MP0010030_abnormal_orbit_morphology1.33375977
59MP0003122_maternal_imprinting1.32996730
60MP0002210_abnormal_sex_determination1.32187894
61MP0008872_abnormal_physiological_respon1.31510683
62MP0002163_abnormal_gland_morphology1.28910621
63MP0005379_endocrine/exocrine_gland_phen1.28663453
64MP0004215_abnormal_myocardial_fiber1.27963312
65MP0000631_abnormal_neuroendocrine_gland1.27500972
66MP0001545_abnormal_hematopoietic_system1.24677757
67MP0005397_hematopoietic_system_phenotyp1.24677757
68MP0004147_increased_porphyrin_level1.24572844
69MP0003718_maternal_effect1.24559082
70MP0001145_abnormal_male_reproductive1.23536252
71MP0005645_abnormal_hypothalamus_physiol1.23412715
72MP0002398_abnormal_bone_marrow1.19892632
73MP0003136_yellow_coat_color1.19157448
74MP0005220_abnormal_exocrine_pancreas1.17521050
75MP0006054_spinal_hemorrhage1.15637478
76MP0000383_abnormal_hair_follicle1.15412129
77MP0000015_abnormal_ear_pigmentation1.14976114
78MP0002736_abnormal_nociception_after1.13880572
79MP0010678_abnormal_skin_adnexa1.13440169
80MP0001968_abnormal_touch/_nociception1.12907171
81MP0000537_abnormal_urethra_morphology1.11888901
82MP0002138_abnormal_hepatobiliary_system1.09539741
83MP0003119_abnormal_digestive_system1.08385501
84MP0009780_abnormal_chondrocyte_physiolo1.07455207
85MP0000689_abnormal_spleen_morphology1.07450294
86MP0000653_abnormal_sex_gland1.06860291
87MP0002722_abnormal_immune_system1.06821593
88MP0001764_abnormal_homeostasis1.06715176
89MP0003315_abnormal_perineum_morphology1.06342185
90MP0005395_other_phenotype1.06186504
91MP0002876_abnormal_thyroid_physiology1.04885769
92MP0002638_abnormal_pupillary_reflex1.04270549
93MP0001929_abnormal_gametogenesis1.02976275
94MP0000358_abnormal_cell_content/1.02173148
95MP0002090_abnormal_vision1.01894696
96MP0008995_early_reproductive_senescence1.01503922
97MP0003221_abnormal_cardiomyocyte_apopto0.98486278
98MP0004043_abnormal_pH_regulation0.98206135
99MP0004133_heterotaxia0.96818194
100MP0001529_abnormal_vocalization0.96653387
101MP0009672_abnormal_birth_weight0.96569918
102MP0005384_cellular_phenotype0.94923796
103MP0006035_abnormal_mitochondrial_morpho0.94859480
104MP0001324_abnormal_eye_pigmentation0.94139456
105MP0001485_abnormal_pinna_reflex0.93257635
106MP0004084_abnormal_cardiac_muscle0.92664909
107MP0003880_abnormal_central_pattern0.92457868
108MP0001188_hyperpigmentation0.92256717
109MP0001986_abnormal_taste_sensitivity0.90974062
110MP0005075_abnormal_melanosome_morpholog0.90774416
111MP0003698_abnormal_male_reproductive0.90057359
112MP0000647_abnormal_sebaceous_gland0.88069286
113MP0001501_abnormal_sleep_pattern0.86971644
114MP0002429_abnormal_blood_cell0.86859594
115MP0005621_abnormal_cell_physiology0.86595329
116MP0006036_abnormal_mitochondrial_physio0.84103363
117MP0001486_abnormal_startle_reflex0.83167906
118MP0003806_abnormal_nucleotide_metabolis0.81524064
119MP0002928_abnormal_bile_duct0.80812901
120MP0002693_abnormal_pancreas_physiology0.80454551
121MP0001756_abnormal_urination0.77758329
122MP0008770_decreased_survivor_rate0.76423090
123MP0005410_abnormal_fertilization0.76102086
124MP0002160_abnormal_reproductive_system0.75992535
125MP0001944_abnormal_pancreas_morphology0.75665329
126MP0009703_decreased_birth_body0.75262933
127MP0004233_abnormal_muscle_weight0.74868451
128MP0010386_abnormal_urinary_bladder0.74861767
129MP0005391_vision/eye_phenotype0.74490095
130MP0002233_abnormal_nose_morphology0.74174223
131MP0005187_abnormal_penis_morphology0.73993245
132MP0002111_abnormal_tail_morphology0.73048046
133MP0000477_abnormal_intestine_morphology0.71966381
134MP0003137_abnormal_impulse_conducting0.71239688
135MP0001119_abnormal_female_reproductive0.70549353
136MP0000716_abnormal_immune_system0.70211989
137MP0001177_atelectasis0.70000191
138MP0003943_abnormal_hepatobiliary_system0.68372957
139MP0009053_abnormal_anal_canal0.66232674
140MP0006292_abnormal_olfactory_placode0.65689604
141MP0010234_abnormal_vibrissa_follicle0.64523525
142MP0002092_abnormal_eye_morphology0.63527087
143MP0005389_reproductive_system_phenotype0.62541215
144MP0003861_abnormal_nervous_system0.62397051
145MP0009278_abnormal_bone_marrow0.61595650
146MP0005076_abnormal_cell_differentiation0.60730866
147MP0002095_abnormal_skin_pigmentation0.58531223
148MP0003937_abnormal_limbs/digits/tail_de0.58059642
149MP0000465_gastrointestinal_hemorrhage0.57439186
150MP0003115_abnormal_respiratory_system0.56543435
151MP0002269_muscular_atrophy0.53329310
152MP0000858_altered_metastatic_potential0.53267775
153MP0009697_abnormal_copulation0.52706642
154MP0002114_abnormal_axial_skeleton0.52472202
155MP0003699_abnormal_female_reproductive0.52158693
156MP0005023_abnormal_wound_healing0.51650585
157MP0000428_abnormal_craniofacial_morphol0.51358818
158MP0002161_abnormal_fertility/fecundity0.51006626
159MP0002751_abnormal_autonomic_nervous0.50881608
160MP0002075_abnormal_coat/hair_pigmentati0.50855498
161MP0005394_taste/olfaction_phenotype0.50791040
162MP0005499_abnormal_olfactory_system0.50791040
163MP0001849_ear_inflammation0.50185606
164MP0003283_abnormal_digestive_organ0.49217702
165MP0001915_intracranial_hemorrhage0.48998327
166MP0008789_abnormal_olfactory_epithelium0.48308122

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.91478218
2Ependymoma (HP:0002888)4.76799727
3Colon cancer (HP:0003003)4.73535984
4Medulloblastoma (HP:0002885)4.04608829
5Agnosia (HP:0010524)3.76693453
6Reticulocytopenia (HP:0001896)3.67393129
7Abnormality of cells of the erythroid lineage (HP:0012130)3.61839000
8Aplastic anemia (HP:0001915)3.60051109
9Pancreatic cysts (HP:0001737)3.49118619
10Abnormal number of erythroid precursors (HP:0012131)3.35452525
11Intestinal atresia (HP:0011100)3.26627161
12Carpal bone hypoplasia (HP:0001498)3.26141880
13Selective tooth agenesis (HP:0001592)3.25962532
14Oral leukoplakia (HP:0002745)3.24392274
15Rhabdomyosarcoma (HP:0002859)3.17913835
16Abnormality of the astrocytes (HP:0100707)3.13842864
17Astrocytoma (HP:0009592)3.13842864
18Cerebral hypomyelination (HP:0006808)3.13265564
19Basal cell carcinoma (HP:0002671)3.12901503
20Abnormality of the anterior horn cell (HP:0006802)3.09645888
21Degeneration of anterior horn cells (HP:0002398)3.09645888
22Breast hypoplasia (HP:0003187)3.08672956
23True hermaphroditism (HP:0010459)3.07042388
24Rough bone trabeculation (HP:0100670)2.96529096
25Methylmalonic acidemia (HP:0002912)2.84661891
26Patellar aplasia (HP:0006443)2.83205071
27Molar tooth sign on MRI (HP:0002419)2.83126763
28Abnormality of midbrain morphology (HP:0002418)2.83126763
29Neoplasm of the pancreas (HP:0002894)2.76940616
30Thrombocytosis (HP:0001894)2.76056103
31CNS hypomyelination (HP:0003429)2.75502260
32Hypothermia (HP:0002045)2.74766355
33Atrophy/Degeneration involving motor neurons (HP:0007373)2.73616092
3411 pairs of ribs (HP:0000878)2.68997984
35Abnormality of the renal cortex (HP:0011035)2.66758066
36Amaurosis fugax (HP:0100576)2.66427540
37Aplasia/Hypoplasia of the patella (HP:0006498)2.66185197
38Glioma (HP:0009733)2.61774647
39Myelodysplasia (HP:0002863)2.58353822
40Premature graying of hair (HP:0002216)2.57154480
41Thyroiditis (HP:0100646)2.55652033
42Medial flaring of the eyebrow (HP:0010747)2.54563248
43Nephronophthisis (HP:0000090)2.50697941
44Aqueductal stenosis (HP:0002410)2.48921984
45Shoulder girdle muscle weakness (HP:0003547)2.48398542
46Macrocytic anemia (HP:0001972)2.47093517
47Pancreatic islet-cell hyperplasia (HP:0004510)2.44303065
48Absent thumb (HP:0009777)2.41381448
49Progressive inability to walk (HP:0002505)2.40796663
50Pallor (HP:0000980)2.40697166
51Renal cortical cysts (HP:0000803)2.39534754
52Microretrognathia (HP:0000308)2.39114629
53Optic nerve coloboma (HP:0000588)2.37042864
54Abnormality of the labia minora (HP:0012880)2.35487287
55Abnormality of chromosome stability (HP:0003220)2.34703435
56Abnormal number of incisors (HP:0011064)2.33101685
57Neoplasm of the oral cavity (HP:0100649)2.32991849
58Neoplasm of the adrenal cortex (HP:0100641)2.32611666
59Poikiloderma (HP:0001029)2.31915111
60Pelvic girdle muscle weakness (HP:0003749)2.31487743
61Abnormality of the preputium (HP:0100587)2.30800711
62Neoplasm of the colon (HP:0100273)2.30024105
63Abnormality of the renal medulla (HP:0100957)2.29963679
64Abnormality of vitamin B metabolism (HP:0004340)2.29428128
65Neoplasm of striated muscle (HP:0009728)2.27957787
66Bone marrow hypocellularity (HP:0005528)2.24112736
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.23484552
68Hyperinsulinemic hypoglycemia (HP:0000825)2.23385872
69Meckel diverticulum (HP:0002245)2.22772402
70Chromsome breakage (HP:0040012)2.22022675
71Cellular immunodeficiency (HP:0005374)2.20905609
72Abnormal lung lobation (HP:0002101)2.20790836
73Cutaneous melanoma (HP:0012056)2.20724738
74Increased nuchal translucency (HP:0010880)2.20668203
75Biliary tract neoplasm (HP:0100574)2.19949285
76Amyotrophic lateral sclerosis (HP:0007354)2.19438574
77Lymphoma (HP:0002665)2.18847029
78Clubbing of toes (HP:0100760)2.18731669
79Gaze-evoked nystagmus (HP:0000640)2.18641915
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.16859460
81Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16846787
82Attenuation of retinal blood vessels (HP:0007843)2.16607751
83Volvulus (HP:0002580)2.15998095
84Aplasia/Hypoplasia of the tongue (HP:0010295)2.15724279
85Abnormality of the pancreatic islet cells (HP:0006476)2.15462773
86Abnormality of endocrine pancreas physiology (HP:0012093)2.15462773
87Sloping forehead (HP:0000340)2.14997925
88Missing ribs (HP:0000921)2.14757511
89Abolished electroretinogram (ERG) (HP:0000550)2.12788603
90Methylmalonic aciduria (HP:0012120)2.12254239
91Overlapping toe (HP:0001845)2.11830643
92Abnormality of the ileum (HP:0001549)2.11626015
93Sparse lateral eyebrow (HP:0005338)2.10863817
94Genital tract atresia (HP:0001827)2.10433319
95Supernumerary spleens (HP:0009799)2.09639462
96Squamous cell carcinoma (HP:0002860)2.07820149
97Chronic hepatic failure (HP:0100626)2.07641106
98Duodenal stenosis (HP:0100867)2.07494363
99Small intestinal stenosis (HP:0012848)2.07494363
100Neoplasm of the rectum (HP:0100743)2.04751519
101Proximal placement of thumb (HP:0009623)2.04600215
102Oligodactyly (hands) (HP:0001180)2.04185399
103Ketoacidosis (HP:0001993)2.02998569
104Congenital primary aphakia (HP:0007707)2.02396706
105Adenoma sebaceum (HP:0009720)2.01075650
106Angiofibromas (HP:0010615)2.01075650
107Hypoglycemic seizures (HP:0002173)1.99939620
108Aplasia/Hypoplasia of the fovea (HP:0008060)1.98370327
109Hypoplasia of the fovea (HP:0007750)1.98370327
110Freckling (HP:0001480)1.97965009
111Glossoptosis (HP:0000162)1.97495044
112Abnormality of the fovea (HP:0000493)1.97079516
113Abnormality of methionine metabolism (HP:0010901)1.96155995
114Deviation of the thumb (HP:0009603)1.95698882
115Abnormal trabecular bone morphology (HP:0100671)1.95256836
116Fair hair (HP:0002286)1.94340698
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94305758
118Abnormality of the musculature of the pelvis (HP:0001469)1.94167232
119Abnormality of the hip-girdle musculature (HP:0001445)1.94167232
120IgM deficiency (HP:0002850)1.93756746
121Cystic liver disease (HP:0006706)1.93280810
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92263483
123Facial hemangioma (HP:0000329)1.92186796
124Abnormality of the vitamin B12 metabolism (HP:0004341)1.92049100
125Gait imbalance (HP:0002141)1.91719092
126Abnormality of the duodenum (HP:0002246)1.91690460
127Ovarian neoplasm (HP:0100615)1.91625066
128Congenital stationary night blindness (HP:0007642)1.90923836
129Bile duct proliferation (HP:0001408)1.90726992
130Abnormal biliary tract physiology (HP:0012439)1.90726992
131Neoplasm of the small intestine (HP:0100833)1.90701760
132Vaginal atresia (HP:0000148)1.89786740
133Cafe-au-lait spot (HP:0000957)1.88717567
134Hypoglycemic coma (HP:0001325)1.87914710
135Gastrointestinal atresia (HP:0002589)1.87133619
136Abnormal biliary tract morphology (HP:0012440)1.86831912
137Hyperventilation (HP:0002883)1.86614924
138Abnormality of glycolysis (HP:0004366)1.86544486
139Increased serum pyruvate (HP:0003542)1.86544486
140Aplasia/Hypoplasia of the uvula (HP:0010293)1.86477130
141Furrowed tongue (HP:0000221)1.86389729
142Facial cleft (HP:0002006)1.86324273
143Abnormality of the calcaneus (HP:0008364)1.85901758
144Breast carcinoma (HP:0003002)1.83713747
145Gonadotropin excess (HP:0000837)1.83092243
146Prominent nose (HP:0000448)1.82924933
147Dandy-Walker malformation (HP:0001305)1.82486585
148Embryonal renal neoplasm (HP:0011794)1.82402386
149Neoplasm of the adrenal gland (HP:0100631)1.81517189
150Preaxial hand polydactyly (HP:0001177)1.81499472
151Neuroblastic tumors (HP:0004376)1.81359487
152Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.81359487
153Neuroblastoma (HP:0003006)1.81359487
154Primitive neuroectodermal tumor (HP:0030065)1.81359487
155Short tibia (HP:0005736)1.80444497
156Nephrogenic diabetes insipidus (HP:0009806)1.78953715
157Pancreatic fibrosis (HP:0100732)1.78944349
158Broad palm (HP:0001169)1.78517079
159Abnormality of macular pigmentation (HP:0008002)1.77981766
160Atresia of the external auditory canal (HP:0000413)1.77920259
161Postaxial foot polydactyly (HP:0001830)1.77789277
162Irregular epiphyses (HP:0010582)1.77451764
163Disproportionate short-trunk short stature (HP:0003521)1.75620724
164Abnormality of the metopic suture (HP:0005556)1.75290249
165Dyschromatopsia (HP:0007641)1.72414356
166Anencephaly (HP:0002323)1.71623888
167Abnormal rod and cone electroretinograms (HP:0008323)1.71141819
168Hyperglycinemia (HP:0002154)1.69710455
169Bifid tongue (HP:0010297)1.68472881
170Progressive macrocephaly (HP:0004481)1.66880048
171Small hand (HP:0200055)1.66660530
172Postaxial hand polydactyly (HP:0001162)1.66179624
173Absent radius (HP:0003974)1.66149255
174Male pseudohermaphroditism (HP:0000037)1.65904175
175Hyperglycemia (HP:0003074)1.65680739
176Pendular nystagmus (HP:0012043)1.65529307
177Inability to walk (HP:0002540)1.65411287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.68844460
2BUB14.36069017
3CDC74.30084319
4WEE13.76197743
5EEF2K3.49225708
6TRIM283.16108868
7WNK33.10778073
8NUAK13.01226246
9EIF2AK12.95927630
10TSSK62.71906729
11NEK22.57571014
12SRPK12.56189489
13NEK12.55524961
14MAP4K22.45923405
15BMPR1B2.43591115
16PASK2.43246430
17MST42.27678953
18MKNK12.27212542
19TNIK2.23250166
20PLK42.09697842
21TTK2.06987548
22ERBB32.05527001
23RPS6KB22.00611206
24ZAK2.00504435
25RPS6KA41.99392514
26TESK21.95974151
27PLK11.89971079
28NME21.86761432
29DYRK31.82962443
30ACVR1B1.75201625
31ATR1.73941766
32TGFBR11.72231524
33BRSK21.70239328
34PLK31.63578058
35CDK71.62142965
36FGFR21.61497908
37STK161.60244069
38CDK191.59276011
39SCYL21.57441298
40EIF2AK31.52503271
41PLK21.41549977
42AURKB1.41427651
43MKNK21.39483068
44MAP4K11.38426485
45CASK1.38015127
46MAP3K81.37061288
47MAPK131.36139879
48STK38L1.34842336
49INSRR1.34826460
50GRK11.34780986
51VRK11.31149485
52MAP3K101.31006861
53CDK121.29922058
54FLT31.28835307
55ADRBK21.28398388
56MAP3K41.27759413
57CHEK11.24614084
58CDK41.19548335
59BCR1.18897472
60STK391.18871714
61STK31.15606714
62NLK1.14319708
63PINK11.13845590
64CHEK21.12024093
65OXSR11.06731231
66ALK1.05232903
67AURKA1.03137621
68EPHA21.01787465
69BRSK10.98387621
70STK100.95608737
71PIK3CG0.95507364
72PAK30.95175494
73BRD40.93966881
74PKN20.89136565
75TLK10.89052851
76MAPKAPK30.88923125
77CDK20.87286007
78CCNB10.85127834
79PAK40.83002938
80YES10.82616733
81CSNK2A20.81240485
82ATM0.78421848
83TAF10.78287773
84CSF1R0.77924108
85LATS20.74628039
86PRKCE0.73350621
87RAF10.72010454
88PIM10.71067847
89EIF2AK20.70563601
90STK240.70548716
91SIK30.70215019
92AKT30.68893664
93NME10.66798032
94BCKDK0.65645385
95CSNK1G20.63431198
96CDK10.62978795
97IRAK10.62443422
98LRRK20.61309567
99PNCK0.57848650
100CSNK2A10.57403017
101FER0.57142630
102CSNK1G30.55229701
103TRPM70.54973222
104CSNK1E0.54675792
105TAOK30.53742864
106PAK10.51212361
107GRK60.51156404
108CDK60.50929477
109EPHA40.50457027
110STK40.50048793
111DYRK20.49682678
112MUSK0.49251329
113PRKCG0.47403026
114WNK40.45829871
115LIMK10.45193095
116NTRK30.43974171
117RPS6KB10.43178477
118ILK0.42642242
119CDK80.41447884
120KIT0.40993430
121LATS10.39819369
122TESK10.39379125
123PRKCI0.38997802
124MAP2K30.38571506
125MAPKAPK50.36711576
126CDK30.35916447
127CSNK1G10.35392095
128PBK0.34185147
129PRKCQ0.33982608
130MAP2K70.33886547
131MAP3K110.33262476
132PRKDC0.33172963
133TEC0.32991668
134CSNK1D0.32020419
135BTK0.31862584
136PHKG20.31828405
137PHKG10.31828405
138DMPK0.31558421
139RPS6KA50.31522651
140PTK2B0.31155621
141KDR0.30765029
142MTOR0.29711111
143CSNK1A1L0.29514061
144TXK0.29308115
145FGFR10.29044078
146PIK3CA0.28998193
147MAP3K120.28937532
148PIM20.28586541
149DAPK10.28351056
150MAPK90.28267346
151SGK20.28116212
152ZAP700.27805260
153MELK0.27038734
154ADRBK10.26889900
155PRKAA20.26776959
156TIE10.26770768
157PDK40.25555285
158PDK30.25555285
159IKBKE0.24954908
160CDK11A0.24160243
161MAPK140.23955791

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.95646263
2Mismatch repair_Homo sapiens_hsa034304.49214703
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.99913467
4Spliceosome_Homo sapiens_hsa030403.67069387
5Ribosome_Homo sapiens_hsa030103.49261950
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.34150763
7RNA transport_Homo sapiens_hsa030133.29590703
8Base excision repair_Homo sapiens_hsa034103.11831179
9RNA polymerase_Homo sapiens_hsa030203.08893909
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.01716058
11Proteasome_Homo sapiens_hsa030502.97458286
12Nucleotide excision repair_Homo sapiens_hsa034202.89892055
13Cell cycle_Homo sapiens_hsa041102.78139405
14Butanoate metabolism_Homo sapiens_hsa006502.71353917
15Propanoate metabolism_Homo sapiens_hsa006402.68968932
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.50258767
17One carbon pool by folate_Homo sapiens_hsa006702.45165700
18Homologous recombination_Homo sapiens_hsa034402.38795696
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31307979
20Pyrimidine metabolism_Homo sapiens_hsa002402.26931261
21RNA degradation_Homo sapiens_hsa030182.19795954
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.16845278
23Non-homologous end-joining_Homo sapiens_hsa034502.14349780
24mRNA surveillance pathway_Homo sapiens_hsa030151.96956477
25Fanconi anemia pathway_Homo sapiens_hsa034601.96600895
26Basal transcription factors_Homo sapiens_hsa030221.79132804
27Phototransduction_Homo sapiens_hsa047441.76897193
28Steroid biosynthesis_Homo sapiens_hsa001001.76477353
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66498743
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56142145
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.53598078
32p53 signaling pathway_Homo sapiens_hsa041151.47826363
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39016207
34Nitrogen metabolism_Homo sapiens_hsa009101.33092185
35Tryptophan metabolism_Homo sapiens_hsa003801.30447144
36Fatty acid elongation_Homo sapiens_hsa000621.29968950
37Oocyte meiosis_Homo sapiens_hsa041141.28578657
38Ether lipid metabolism_Homo sapiens_hsa005651.27967126
39Epstein-Barr virus infection_Homo sapiens_hsa051691.27774658
40Purine metabolism_Homo sapiens_hsa002301.24724322
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18108821
42Circadian rhythm_Homo sapiens_hsa047101.16063552
43Antigen processing and presentation_Homo sapiens_hsa046121.09976195
44Linoleic acid metabolism_Homo sapiens_hsa005911.08266005
45Caffeine metabolism_Homo sapiens_hsa002321.05954675
46Viral carcinogenesis_Homo sapiens_hsa052031.04578287
47Peroxisome_Homo sapiens_hsa041461.02400245
48Regulation of autophagy_Homo sapiens_hsa041401.00273171
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98458803
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97736812
51Selenocompound metabolism_Homo sapiens_hsa004500.96107220
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95567669
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95530751
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95432424
55Sulfur metabolism_Homo sapiens_hsa009200.94645514
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93487560
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.88023835
58Fatty acid metabolism_Homo sapiens_hsa012120.86642125
59Systemic lupus erythematosus_Homo sapiens_hsa053220.86524384
60Biosynthesis of amino acids_Homo sapiens_hsa012300.85665247
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85019353
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84806690
63Herpes simplex infection_Homo sapiens_hsa051680.84633897
64ABC transporters_Homo sapiens_hsa020100.83903012
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.83438115
66Folate biosynthesis_Homo sapiens_hsa007900.82849906
67HTLV-I infection_Homo sapiens_hsa051660.82701727
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81096891
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80518887
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77558537
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76641078
72Pentose phosphate pathway_Homo sapiens_hsa000300.76336228
73Thyroid cancer_Homo sapiens_hsa052160.75430708
74Colorectal cancer_Homo sapiens_hsa052100.74776085
75Retinol metabolism_Homo sapiens_hsa008300.74149512
76Fatty acid degradation_Homo sapiens_hsa000710.73587234
77Olfactory transduction_Homo sapiens_hsa047400.73475001
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70695810
79Primary immunodeficiency_Homo sapiens_hsa053400.69250100
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.66184593
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65031118
82Fructose and mannose metabolism_Homo sapiens_hsa000510.63861960
83beta-Alanine metabolism_Homo sapiens_hsa004100.63608079
84Taste transduction_Homo sapiens_hsa047420.63385481
85Nicotine addiction_Homo sapiens_hsa050330.62178339
86mTOR signaling pathway_Homo sapiens_hsa041500.59092896
87Chemical carcinogenesis_Homo sapiens_hsa052040.58730097
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.58221279
89Oxidative phosphorylation_Homo sapiens_hsa001900.58040857
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57691509
91Hepatitis B_Homo sapiens_hsa051610.56967203
92Metabolic pathways_Homo sapiens_hsa011000.56853656
93MicroRNAs in cancer_Homo sapiens_hsa052060.56361272
94Small cell lung cancer_Homo sapiens_hsa052220.54439830
95Vitamin digestion and absorption_Homo sapiens_hsa049770.52962626
96N-Glycan biosynthesis_Homo sapiens_hsa005100.52823307
97Protein export_Homo sapiens_hsa030600.51496019
98Lysine degradation_Homo sapiens_hsa003100.51193874
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.49697436
100Insulin secretion_Homo sapiens_hsa049110.49145980
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48893113
102Dorso-ventral axis formation_Homo sapiens_hsa043200.47051846
103Acute myeloid leukemia_Homo sapiens_hsa052210.46256008
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46164647
105Legionellosis_Homo sapiens_hsa051340.46101029
106Alcoholism_Homo sapiens_hsa050340.45625680
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45002337
108Pyruvate metabolism_Homo sapiens_hsa006200.44444095
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.44336117
110Vitamin B6 metabolism_Homo sapiens_hsa007500.44297163
111Apoptosis_Homo sapiens_hsa042100.44259595
112Collecting duct acid secretion_Homo sapiens_hsa049660.42824047
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42517334
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42245841
115Type I diabetes mellitus_Homo sapiens_hsa049400.42147767
116Serotonergic synapse_Homo sapiens_hsa047260.41316457
117Chronic myeloid leukemia_Homo sapiens_hsa052200.40259990
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40090872
119Shigellosis_Homo sapiens_hsa051310.38277785
120Hedgehog signaling pathway_Homo sapiens_hsa043400.38243487
121Glycerolipid metabolism_Homo sapiens_hsa005610.36981367
122Measles_Homo sapiens_hsa051620.36254606
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36177815
124Carbon metabolism_Homo sapiens_hsa012000.35813234
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34144399
126Non-small cell lung cancer_Homo sapiens_hsa052230.33957179
127Sphingolipid metabolism_Homo sapiens_hsa006000.33324837
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33209955
129HIF-1 signaling pathway_Homo sapiens_hsa040660.32604443
130Hippo signaling pathway_Homo sapiens_hsa043900.31624686
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31540629
132Huntingtons disease_Homo sapiens_hsa050160.27311602
133Pancreatic cancer_Homo sapiens_hsa052120.26209547
134Wnt signaling pathway_Homo sapiens_hsa043100.25995338
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25704185
136Notch signaling pathway_Homo sapiens_hsa043300.25329617
137TGF-beta signaling pathway_Homo sapiens_hsa043500.25216844
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24797544
1392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24358182
140Sulfur relay system_Homo sapiens_hsa041220.23631024
141Arachidonic acid metabolism_Homo sapiens_hsa005900.23366643
142T cell receptor signaling pathway_Homo sapiens_hsa046600.23170362
143Pathways in cancer_Homo sapiens_hsa052000.21366021
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20624072
145Endometrial cancer_Homo sapiens_hsa052130.19420507
146Influenza A_Homo sapiens_hsa051640.18935122
147B cell receptor signaling pathway_Homo sapiens_hsa046620.17757454
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16966713
149AMPK signaling pathway_Homo sapiens_hsa041520.16827579
150Galactose metabolism_Homo sapiens_hsa000520.14799027
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.13918098
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12780878
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11827259
154Viral myocarditis_Homo sapiens_hsa054160.11345924
155Prostate cancer_Homo sapiens_hsa052150.11286949
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10816482
157Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.08149271
158Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.07815323
159Platelet activation_Homo sapiens_hsa046110.07486339
160Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.07216673
161Glutathione metabolism_Homo sapiens_hsa004800.06986257
162Melanoma_Homo sapiens_hsa052180.05918936
163Parkinsons disease_Homo sapiens_hsa050120.05795568
164Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04935869

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