THRSP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid homeostasis (GO:0055089)9.17116502
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.39670113
3L-phenylalanine catabolic process (GO:0006559)6.39670113
4alpha-linolenic acid metabolic process (GO:0036109)6.20877735
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.09613999
6L-phenylalanine metabolic process (GO:0006558)6.09613999
7diacylglycerol metabolic process (GO:0046339)5.87792156
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.78351390
9ethanol metabolic process (GO:0006067)5.70693146
10aromatic amino acid family catabolic process (GO:0009074)5.55764535
11long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.51615020
12primary alcohol metabolic process (GO:0034308)5.33820750
13NADH metabolic process (GO:0006734)5.33342035
14CDP-diacylglycerol biosynthetic process (GO:0016024)5.29570494
15glycerolipid catabolic process (GO:0046503)5.13820920
16lipid storage (GO:0019915)5.11226325
17regulation of triglyceride catabolic process (GO:0010896)5.07118434
18CDP-diacylglycerol metabolic process (GO:0046341)5.02395458
19brown fat cell differentiation (GO:0050873)4.93609132
20sulfur amino acid catabolic process (GO:0000098)4.88745391
21acetyl-CoA metabolic process (GO:0006084)4.86548890
22bile acid biosynthetic process (GO:0006699)4.85504401
23indole-containing compound catabolic process (GO:0042436)4.81593038
24indolalkylamine catabolic process (GO:0046218)4.81593038
25tryptophan catabolic process (GO:0006569)4.81593038
26biotin metabolic process (GO:0006768)4.80727253
27complement activation, alternative pathway (GO:0006957)4.79011719
28acylglycerol metabolic process (GO:0006639)4.73582042
29kynurenine metabolic process (GO:0070189)4.72957234
30urea cycle (GO:0000050)4.70069381
31urea metabolic process (GO:0019627)4.70069381
32neutral lipid metabolic process (GO:0006638)4.67278497
33plasma lipoprotein particle clearance (GO:0034381)4.65171172
34regulation of cholesterol storage (GO:0010885)4.63916537
35retinol metabolic process (GO:0042572)4.62833074
36high-density lipoprotein particle remodeling (GO:0034375)4.62520440
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.58680251
38glyoxylate metabolic process (GO:0046487)4.54633114
39acylglycerol homeostasis (GO:0055090)4.54498850
40triglyceride homeostasis (GO:0070328)4.54498850
41tryptophan metabolic process (GO:0006568)4.52433228
42fatty acid transmembrane transport (GO:1902001)4.50258337
43lipid particle organization (GO:0034389)4.48350712
44white fat cell differentiation (GO:0050872)4.42757980
45tricarboxylic acid metabolic process (GO:0072350)4.37610211
46peptidyl-glutamic acid carboxylation (GO:0017187)4.37185100
47protein carboxylation (GO:0018214)4.37185100
48nitrogen cycle metabolic process (GO:0071941)4.34355036
49positive regulation of fatty acid beta-oxidation (GO:0032000)4.33908119
50valine metabolic process (GO:0006573)4.33873819
51cysteine metabolic process (GO:0006534)4.33830362
52regulation of sequestering of triglyceride (GO:0010889)4.33015299
53fatty-acyl-CoA biosynthetic process (GO:0046949)4.30373485
54serine family amino acid catabolic process (GO:0009071)4.29656786
55negative regulation of fibrinolysis (GO:0051918)4.28678037
56lysine metabolic process (GO:0006553)4.28334949
57lysine catabolic process (GO:0006554)4.28334949
58regulation of protein activation cascade (GO:2000257)4.27288394
59amino-acid betaine metabolic process (GO:0006577)4.26584482
60bile acid metabolic process (GO:0008206)4.25687285
61low-density lipoprotein particle clearance (GO:0034383)4.25260222
62positive regulation of lipid catabolic process (GO:0050996)4.23707006
63oxaloacetate metabolic process (GO:0006107)4.23214437
64acyl-CoA biosynthetic process (GO:0071616)4.23196050
65thioester biosynthetic process (GO:0035384)4.23196050
66reverse cholesterol transport (GO:0043691)4.22331078
67ethanol oxidation (GO:0006069)4.21224827
68short-chain fatty acid metabolic process (GO:0046459)4.20259721
69fatty acid beta-oxidation (GO:0006635)4.19789038
70regulation of cholesterol esterification (GO:0010872)4.14446665
71daunorubicin metabolic process (GO:0044597)4.14232320
72polyketide metabolic process (GO:0030638)4.14232320
73doxorubicin metabolic process (GO:0044598)4.14232320
74regulation of fibrinolysis (GO:0051917)4.13209728
75protein-lipid complex remodeling (GO:0034368)4.12769248
76macromolecular complex remodeling (GO:0034367)4.12769248
77plasma lipoprotein particle remodeling (GO:0034369)4.12769248
78tyrosine metabolic process (GO:0006570)4.12459467
79response to dietary excess (GO:0002021)4.12073252
80alpha-amino acid catabolic process (GO:1901606)4.08234672
81carnitine shuttle (GO:0006853)4.07808382
82triglyceride catabolic process (GO:0019433)4.07046740
83neutral lipid catabolic process (GO:0046461)4.03896636
84acylglycerol catabolic process (GO:0046464)4.03896636
85regulation of complement activation (GO:0030449)4.03636244
86fatty acid oxidation (GO:0019395)4.02388966
87cellular ketone body metabolic process (GO:0046950)4.00074082
88aromatic amino acid family metabolic process (GO:0009072)3.98624724
89lipid oxidation (GO:0034440)3.96565942
90phospholipid efflux (GO:0033700)3.95983090
91fatty acid catabolic process (GO:0009062)3.94282365
92long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.93346746
93glycerol metabolic process (GO:0006071)3.91341830
94positive regulation of lipid storage (GO:0010884)3.91111621
95coenzyme catabolic process (GO:0009109)3.87407769
96homocysteine metabolic process (GO:0050667)3.86252581
97positive regulation of fatty acid oxidation (GO:0046321)3.84807110
98cellular amino acid catabolic process (GO:0009063)3.84725985
99negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.84017083
100primary alcohol catabolic process (GO:0034310)3.81747838
101negative regulation of lipase activity (GO:0060192)3.81723544
102positive regulation of cholesterol efflux (GO:0010875)3.80551905
103branched-chain amino acid catabolic process (GO:0009083)3.78979752
104monocarboxylic acid catabolic process (GO:0072329)3.78797651
105linoleic acid metabolic process (GO:0043651)3.75068158
106fatty-acyl-CoA metabolic process (GO:0035337)3.74506885
107phospholipid homeostasis (GO:0055091)3.72954675
108negative regulation of cholesterol transport (GO:0032375)3.72783812
109negative regulation of sterol transport (GO:0032372)3.72783812
110response to phenylpropanoid (GO:0080184)3.71658512
1112-oxoglutarate metabolic process (GO:0006103)3.68201174
112organic acid catabolic process (GO:0016054)3.65563955
113carboxylic acid catabolic process (GO:0046395)3.65563955
114aminoglycoside antibiotic metabolic process (GO:0030647)3.63271261
115positive regulation of triglyceride metabolic process (GO:0090208)3.63268148
116thioester metabolic process (GO:0035383)3.62904043
117acyl-CoA metabolic process (GO:0006637)3.62904043
118very long-chain fatty acid metabolic process (GO:0000038)3.61079637
119branched-chain amino acid metabolic process (GO:0009081)3.59007965
120positive regulation of lipoprotein lipase activity (GO:0051006)3.58945666
121positive regulation of triglyceride lipase activity (GO:0061365)3.58945666
122triglyceride metabolic process (GO:0006641)3.57821688
123phosphatidic acid biosynthetic process (GO:0006654)3.57644767
124phosphatidic acid metabolic process (GO:0046473)3.57644767
125regulation of fatty acid beta-oxidation (GO:0031998)3.56052877
126fatty acid elongation (GO:0030497)3.55761639
127positive regulation of glycolytic process (GO:0045821)3.54608488
128alditol metabolic process (GO:0019400)3.54358451
129positive regulation of sterol transport (GO:0032373)3.54234648
130positive regulation of cholesterol transport (GO:0032376)3.54234648
131regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.52785758
132positive regulation of fatty acid metabolic process (GO:0045923)3.52250078
133carnitine metabolic process (GO:0009437)3.51175119
134transcytosis (GO:0045056)3.49747298
135triglyceride biosynthetic process (GO:0019432)3.49054693
136cholesterol efflux (GO:0033344)3.48607454
137regulation of glycogen (starch) synthase activity (GO:2000465)3.45928878
138acylglycerol biosynthetic process (GO:0046463)3.44457127
139neutral lipid biosynthetic process (GO:0046460)3.44457127
140glutamate metabolic process (GO:0006536)3.44297111
141ketone body metabolic process (GO:1902224)3.44256755
142bile acid and bile salt transport (GO:0015721)3.43269898
143protein heterotrimerization (GO:0070208)3.40105474
144regulation of sterol transport (GO:0032371)3.37129631
145regulation of cholesterol transport (GO:0032374)3.37129631
146regulation of macrophage derived foam cell differentiation (GO:0010743)3.31284593
147regulation of cAMP-dependent protein kinase activity (GO:2000479)3.25683856
148L-serine transport (GO:0015825)3.19201723
149regulation of lipid catabolic process (GO:0050994)3.15286831
150negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.14914984
151positive regulation of glomerulus development (GO:0090193)3.13975104
152polyol transport (GO:0015791)3.10628608
153negative regulation of lipid catabolic process (GO:0050995)3.10101682
154regulation of lipid storage (GO:0010883)3.03979511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.32017490
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.38765229
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.29972720
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.89184264
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.60558904
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.79721039
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.08940589
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.79634011
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.56399783
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.07571448
11CLOCK_20551151_ChIP-Seq_293T_Human2.63384001
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1205499
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92314343
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66149693
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.64873949
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60595692
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.50353004
18GATA1_22025678_ChIP-Seq_K562_Human1.43441544
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29897170
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25489813
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21281450
22* HNF4A_19822575_ChIP-Seq_HepG2_Human1.21044244
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20403103
24* HTT_18923047_ChIP-ChIP_STHdh_Human1.15076181
25* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10674622
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08568477
27DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07732124
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06988273
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04473556
30* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00608125
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00396900
32ZNF263_19887448_ChIP-Seq_K562_Human0.99788394
33ESR2_21235772_ChIP-Seq_MCF-7_Human0.99643532
34* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98301788
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97118515
36PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.95312034
37PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95234853
38GATA2_21666600_ChIP-Seq_HMVEC_Human0.93447404
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93001153
40RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92379597
41EOMES_21245162_ChIP-Seq_HESCs_Human0.91066675
42SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87298811
43CTCF_27219007_Chip-Seq_Bcells_Human0.84682353
44PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84076012
45SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83435569
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83245226
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82824311
48ELK3_25401928_ChIP-Seq_HUVEC_Human0.82026005
49* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81830037
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81758853
51* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81214732
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81003893
53NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81003893
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80960352
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79979459
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.79060830
57GATA4_25053715_ChIP-Seq_YYC3_Human0.77614447
58RNF2_18974828_ChIP-Seq_MESCs_Mouse0.76914739
59EZH2_18974828_ChIP-Seq_MESCs_Mouse0.76914739
60SA1_22415368_ChIP-Seq_MEFs_Mouse0.75774730
61CSB_26484114_Chip-Seq_FIBROBLAST_Human0.75722078
62HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74979736
63ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74522136
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.72363614
65MTF2_20144788_ChIP-Seq_MESCs_Mouse0.72262901
66SMC1_22415368_ChIP-Seq_MEFs_Mouse0.71650806
67BCAT_22108803_ChIP-Seq_LS180_Human0.70926138
68P68_20966046_ChIP-Seq_HELA_Human0.70432582
69RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69885672
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69859067
71TP53_20018659_ChIP-ChIP_R1E_Mouse0.69698662
72SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68244106
73CJUN_26792858_Chip-Seq_BT549_Human0.68069615
74RACK7_27058665_Chip-Seq_MCF-7_Human0.68060350
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.67257358
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67188419
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.67046552
78FOXO3_23340844_ChIP-Seq_DLD1_Human0.66984936
79TRIM28_21343339_ChIP-Seq_HEK293_Human0.66916919
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.66776200
81SOX9_24532713_ChIP-Seq_HFSC_Mouse0.66696950
82SOX2_21211035_ChIP-Seq_LN229_Human0.66581637
83EED_16625203_ChIP-ChIP_MESCs_Mouse0.65785416
84SMC4_20622854_ChIP-Seq_HELA_Human0.64504522
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.64376066
86PIAS1_25552417_ChIP-Seq_VCAP_Human0.63316730
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.62808002
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.62722893
89KLF4_19829295_ChIP-Seq_ESCs_Human0.62549038
90NFIB_24661679_ChIP-Seq_LUNG_Mouse0.62394779
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.62359371
92STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.62278723
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.61296421
94CEBPB_22108803_ChIP-Seq_LS180_Human0.60864250
95TBX20_22080862_ChIP-Seq_HEART_Mouse0.60183753
96TBX20_22328084_ChIP-Seq_HEART_Mouse0.60183753
97* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.59824078
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.57863353
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57848253
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.57773483
101TET1_21451524_ChIP-Seq_MESCs_Mouse0.57256624
102IRF8_22096565_ChIP-ChIP_GC-B_Human0.57023087
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56483247
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.55972729
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.55791669
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.54081188
107LXR_22292898_ChIP-Seq_THP-1_Human0.53613938
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.53512422
109* FOXA1_25552417_ChIP-Seq_VCAP_Human0.53247729
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53112998
111ERG_21242973_ChIP-ChIP_JURKAT_Human0.53097673
112* CBP_21632823_ChIP-Seq_H3396_Human0.52298195
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.51890336
114* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51330896
115GATA1_19941826_ChIP-Seq_K562_Human0.51312202
116TP63_17297297_ChIP-ChIP_HaCaT_Human0.50024811
117KAP1_22055183_ChIP-Seq_ESCs_Mouse0.49681675
118GATA2_19941826_ChIP-Seq_K562_Human0.48599514
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.47293563
120SOX2_20726797_ChIP-Seq_SW620_Human0.46531838
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.45927019
122MYC_19915707_ChIP-ChIP_AK7_Human0.45513113
123GATA3_24758297_ChIP-Seq_MCF-7_Human0.45454631
124RARB_24833708_ChIP-Seq_LIVER_Mouse0.45428452
125AR_20517297_ChIP-Seq_VCAP_Human0.45265085
126RXR_22108803_ChIP-Seq_LS180_Human0.44935558
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.44774257
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.43943060
129* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43832354
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.43619847
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.43455974
132ESET_19884257_ChIP-Seq_ESCs_Mouse0.43087757
133STAT1_17558387_ChIP-Seq_HELA_Human0.43077188
134P53_21459846_ChIP-Seq_SAOS-2_Human0.41942643
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41847999
136CDX2_22108803_ChIP-Seq_LS180_Human0.41600857
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.41100621
138CBP_20019798_ChIP-Seq_JUKART_Human0.41100621
139ERG_20517297_ChIP-Seq_VCAP_Human0.40746087
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.40552755
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.39567015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.44192321
2MP0005360_urolithiasis6.44991158
3MP0005365_abnormal_bile_salt5.55256184
4MP0005085_abnormal_gallbladder_physiolo5.36160887
5MP0008875_abnormal_xenobiotic_pharmacok4.28364038
6MP0010329_abnormal_lipoprotein_level3.98734005
7MP0005670_abnormal_white_adipose3.50582440
8MP0003806_abnormal_nucleotide_metabolis3.39970445
9MP0003252_abnormal_bile_duct3.23695487
10MP0009840_abnormal_foam_cell2.88551284
11MP0005332_abnormal_amino_acid2.64408928
12MP0005083_abnormal_biliary_tract2.59017890
13* MP0002118_abnormal_lipid_homeostasis2.56186750
14MP0003191_abnormal_cellular_cholesterol2.46751790
15MP0004130_abnormal_muscle_cell2.39480640
16MP0005666_abnormal_adipose_tissue2.29095955
17MP0000609_abnormal_liver_physiology2.28908424
18MP0001666_abnormal_nutrient_absorption2.20410121
19MP0003195_calcinosis2.05361133
20MP0004019_abnormal_vitamin_homeostasis2.00181801
21MP0002971_abnormal_brown_adipose1.86844543
22MP0005319_abnormal_enzyme/_coenzyme1.80860381
23MP0005584_abnormal_enzyme/coenzyme_acti1.76095132
24MP0004185_abnormal_adipocyte_glucose1.72069329
25MP0001764_abnormal_homeostasis1.63894450
26MP0002876_abnormal_thyroid_physiology1.60833266
27MP0005334_abnormal_fat_pad1.55391405
28MP0002837_dystrophic_cardiac_calcinosis1.53903015
29MP0003186_abnormal_redox_activity1.52144135
30MP0003011_delayed_dark_adaptation1.51664583
31MP0002254_reproductive_system_inflammat1.49823445
32MP0002138_abnormal_hepatobiliary_system1.48335339
33MP0003868_abnormal_feces_composition1.41832023
34MP0005375_adipose_tissue_phenotype1.40003430
35MP0003828_pulmonary_edema1.34374011
36MP0005535_abnormal_body_temperature1.33592646
37MP0003705_abnormal_hypodermis_morpholog1.29524507
38MP0000343_altered_response_to1.25025480
39MP0003690_abnormal_glial_cell1.23794995
40MP0009643_abnormal_urine_homeostasis1.23583028
41MP0005503_abnormal_tendon_morphology1.23322878
42MP0005647_abnormal_sex_gland1.22289468
43MP0009115_abnormal_fat_cell1.20573608
44* MP0001881_abnormal_mammary_gland1.19354406
45MP0002909_abnormal_adrenal_gland1.18786590
46MP0001661_extended_life_span1.18677496
47MP0002078_abnormal_glucose_homeostasis1.18489084
48MP0009697_abnormal_copulation1.18199649
49MP0005379_endocrine/exocrine_gland_phen1.17837946
50MP0006036_abnormal_mitochondrial_physio1.15977931
51MP0000751_myopathy1.15748593
52MP0000604_amyloidosis1.09377245
53MP0008438_abnormal_cutaneous_collagen1.08424031
54MP0002970_abnormal_white_adipose1.06892311
55MP0005448_abnormal_energy_balance1.04820608
56MP0000598_abnormal_liver_morphology1.04158196
57MP0005451_abnormal_body_composition1.01908198
58MP0003279_aneurysm0.99077414
59MP0009763_increased_sensitivity_to0.97033672
60MP0001544_abnormal_cardiovascular_syste0.94834775
61MP0005385_cardiovascular_system_phenoty0.94834775
62MP0003656_abnormal_erythrocyte_physiolo0.93274069
63MP0009764_decreased_sensitivity_to0.87049094
64MP0003950_abnormal_plasma_membrane0.86413642
65MP0003948_abnormal_gas_homeostasis0.84903243
66MP0003329_amyloid_beta_deposits0.84278498
67MP0009642_abnormal_blood_homeostasis0.83992525
68MP0002108_abnormal_muscle_morphology0.79899395
69MP0005376_homeostasis/metabolism_phenot0.77483638
70MP0004272_abnormal_basement_membrane0.77094532
71MP0005636_abnormal_mineral_homeostasis0.73973888
72MP0002638_abnormal_pupillary_reflex0.73722778
73MP0010368_abnormal_lymphatic_system0.73228030
74MP0008469_abnormal_protein_level0.72779986
75MP0003959_abnormal_lean_body0.72168793
76MP0000013_abnormal_adipose_tissue0.70455088
77MP0003724_increased_susceptibility_to0.69466384
78MP0001756_abnormal_urination0.68991415
79MP0005501_abnormal_skin_physiology0.68369444
80MP0005452_abnormal_adipose_tissue0.67870184
81MP0003953_abnormal_hormone_level0.66177378
82MP0004087_abnormal_muscle_fiber0.65776271
83MP0002796_impaired_skin_barrier0.64737949
84MP0000759_abnormal_skeletal_muscle0.64389438
85MP0000003_abnormal_adipose_tissue0.64353124
86MP0005275_abnormal_skin_tensile0.64122702
87MP0006276_abnormal_autonomic_nervous0.61775993
88MP0009765_abnormal_xenobiotic_induced0.61485138
89MP0005266_abnormal_metabolism0.60519089
90MP0004381_abnormal_hair_follicle0.59399716
91MP0001944_abnormal_pancreas_morphology0.58151272
92MP0004215_abnormal_myocardial_fiber0.57794129
93MP0000858_altered_metastatic_potential0.56179460
94MP0000639_abnormal_adrenal_gland0.54476324
95MP0008775_abnormal_heart_ventricle0.53405949
96MP0005084_abnormal_gallbladder_morpholo0.52855569
97MP0008872_abnormal_physiological_respon0.52551816
98MP0001853_heart_inflammation0.52148997
99MP0002295_abnormal_pulmonary_circulatio0.51464014
100MP0001177_atelectasis0.51414595
101MP0000749_muscle_degeneration0.50783569
102MP0003075_altered_response_to0.50474713
103MP0001958_emphysema0.47828522
104MP0004782_abnormal_surfactant_physiolog0.47702465
105MP0000230_abnormal_systemic_arterial0.47518463
106MP0000767_abnormal_smooth_muscle0.47256578
107MP0003879_abnormal_hair_cell0.46985147
108MP0002168_other_aberrant_phenotype0.46663761
109MP0005164_abnormal_response_to0.45764685
110MP0002060_abnormal_skin_morphology0.45369927
111MP0006035_abnormal_mitochondrial_morpho0.45118484
112MP0002090_abnormal_vision0.44841794
113MP0005395_other_phenotype0.43786035
114MP0008874_decreased_physiological_sensi0.43508704
115MP0002136_abnormal_kidney_physiology0.43101930
116MP0005220_abnormal_exocrine_pancreas0.42763769
117MP0002933_joint_inflammation0.42679761
118MP0009672_abnormal_birth_weight0.42252453
119MP0005408_hypopigmentation0.39904811
120MP0000249_abnormal_blood_vessel0.38643857
121MP0002332_abnormal_exercise_endurance0.38385334
122MP0000427_abnormal_hair_cycle0.37329519
123MP0003638_abnormal_response/metabolism_0.36708932
124MP0006138_congestive_heart_failure0.36696068
125MP0005595_abnormal_vascular_smooth0.36129545
126MP0009780_abnormal_chondrocyte_physiolo0.35516056
127MP0005167_abnormal_blood-brain_barrier0.34338554
128MP0004147_increased_porphyrin_level0.33992039
129MP0002069_abnormal_eating/drinking_beha0.31721880
130MP0004883_abnormal_blood_vessel0.31599235

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.26350393
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.18036774
3Intrahepatic cholestasis (HP:0001406)5.88094952
4Xanthomatosis (HP:0000991)5.81050082
5Hyperlipoproteinemia (HP:0010980)5.51156834
6Hyperglycinuria (HP:0003108)5.41069408
7Hypobetalipoproteinemia (HP:0003563)5.31769291
8Prolonged partial thromboplastin time (HP:0003645)5.25033050
9Abnormality of monocarboxylic acid metabolism (HP:0010996)5.23724359
10Complement deficiency (HP:0004431)5.08143661
11Abnormality of serine family amino acid metabolism (HP:0010894)5.06425280
12Abnormality of glycine metabolism (HP:0010895)5.06425280
13Hyperglycinemia (HP:0002154)4.92719233
14Hyperammonemia (HP:0001987)4.82234690
15Increased serum pyruvate (HP:0003542)4.77234467
16Ketosis (HP:0001946)4.75527403
17Hypolipoproteinemia (HP:0010981)4.49585395
18Hypoglycemic coma (HP:0001325)4.47060370
19Hypoalphalipoproteinemia (HP:0003233)4.39946045
20Epidermoid cyst (HP:0200040)4.39025451
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.28854097
22Abnormality of glycolysis (HP:0004366)4.22405425
23Abnormality of fatty-acid metabolism (HP:0004359)4.04486318
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.94251275
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.93936642
26Ketoacidosis (HP:0001993)3.88051673
27Joint hemorrhage (HP:0005261)3.81455268
28Protrusio acetabuli (HP:0003179)3.72478879
29Insulin-resistant diabetes mellitus (HP:0000831)3.72447821
30Abnormality of complement system (HP:0005339)3.60738123
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.54392238
32Abnormality of alanine metabolism (HP:0010916)3.54392238
33Hyperalaninemia (HP:0003348)3.54392238
34Abnormality of the common coagulation pathway (HP:0010990)3.51608920
35Hypercholesterolemia (HP:0003124)3.49350079
36Increased variability in muscle fiber diameter (HP:0003557)3.48761881
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.45418765
38Abnormality of methionine metabolism (HP:0010901)3.40416698
39Abnormality of sulfur amino acid metabolism (HP:0004339)3.39395709
40Abnormal hemoglobin (HP:0011902)3.33909061
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.27801171
42Dicarboxylic aciduria (HP:0003215)3.27801171
43Abnormality of serum amino acid levels (HP:0003112)3.26975659
44Fat malabsorption (HP:0002630)3.23820512
45Abnormality of the intrinsic pathway (HP:0010989)3.13104674
46Growth hormone excess (HP:0000845)3.09871837
47Hypertriglyceridemia (HP:0002155)2.99973581
48Bone cyst (HP:0012062)2.98196143
49Long foot (HP:0001833)2.92829457
50Myocardial infarction (HP:0001658)2.91893248
51Abnormality of purine metabolism (HP:0004352)2.90564929
52Delayed CNS myelination (HP:0002188)2.88963923
53Vertebral compression fractures (HP:0002953)2.88441929
54Difficulty running (HP:0009046)2.87866052
55Lethargy (HP:0001254)2.85861094
56Metabolic acidosis (HP:0001942)2.84393287
57Abnormality of nucleobase metabolism (HP:0010932)2.82924014
58Infantile muscular hypotonia (HP:0008947)2.81621404
59Abnormality of skeletal muscle fiber size (HP:0012084)2.81583462
60Conjugated hyperbilirubinemia (HP:0002908)2.80695870
61Hypercortisolism (HP:0001578)2.79994281
62Hyperbilirubinemia (HP:0002904)2.79143834
63Skin nodule (HP:0200036)2.78045323
64Abnormality of proline metabolism (HP:0010907)2.74577031
65Hydroxyprolinuria (HP:0003080)2.74577031
66Hypoglycemic seizures (HP:0002173)2.71060367
67Abnormality of pyrimidine metabolism (HP:0004353)2.67642183
68Oligomenorrhea (HP:0000876)2.62463500
69Rickets (HP:0002748)2.59077711
70Cerebral edema (HP:0002181)2.58720269
71Back pain (HP:0003418)2.58360533
72Systemic lupus erythematosus (HP:0002725)2.56738034
73Abnormal eating behavior (HP:0100738)2.56475553
74Polyphagia (HP:0002591)2.50482224
75Ileus (HP:0002595)2.50198146
76Pancreatitis (HP:0001733)2.48673823
77Steatorrhea (HP:0002570)2.46676876
78Polycythemia (HP:0001901)2.45700961
79Myoglobinuria (HP:0002913)2.44903056
80Reduced subcutaneous adipose tissue (HP:0003758)2.44412521
81Hepatocellular carcinoma (HP:0001402)2.39947461
82Acanthosis nigricans (HP:0000956)2.39782502
83Axonal loss (HP:0003447)2.37140831
84Brushfield spots (HP:0001088)2.33458063
85Hemorrhage of the eye (HP:0011885)2.33388613
86Generalized aminoaciduria (HP:0002909)2.32673895
87Abnormal gallbladder morphology (HP:0012437)2.30742602
88Vomiting (HP:0002013)2.30349239
89Hypophosphatemic rickets (HP:0004912)2.25375501
90Cholelithiasis (HP:0001081)2.24876774
91Irritability (HP:0000737)2.23258787
92Amyloidosis (HP:0011034)2.22014466
93Cholecystitis (HP:0001082)2.19183517
94Abnormal gallbladder physiology (HP:0012438)2.19183517
95Hyperinsulinemic hypoglycemia (HP:0000825)2.18606057
96Vascular calcification (HP:0004934)2.15199943
97Ectopia lentis (HP:0001083)2.13421372
98Gout (HP:0001997)2.12439035
99Hyperglycemia (HP:0003074)2.11691303
100Premature rupture of membranes (HP:0001788)2.10986399
101Abnormal cartilage morphology (HP:0002763)2.10410722
102Spastic diplegia (HP:0001264)2.10310530
103Prominent supraorbital ridges (HP:0000336)2.10245774
104Hypochromic microcytic anemia (HP:0004840)2.07612587
105Spontaneous abortion (HP:0005268)2.07582456
106Renal cortical cysts (HP:0000803)2.07131708
107Subcapsular cataract (HP:0000523)2.04529699
108Increased muscle lipid content (HP:0009058)2.01281583
109Neonatal onset (HP:0003623)2.00975328
110Late onset (HP:0003584)2.00640738
111Sensorimotor neuropathy (HP:0007141)1.99959258
112Mitral stenosis (HP:0001718)1.99130309
113Cardiovascular calcification (HP:0011915)1.98231123
114Abnormality of the periventricular white matter (HP:0002518)1.97553515
115Acanthocytosis (HP:0001927)1.97230663
116Enlarged kidneys (HP:0000105)1.96329799
117Esophageal varix (HP:0002040)1.96105351
118Nausea (HP:0002018)1.95761580
119Rhabdomyolysis (HP:0003201)1.93199928
120Hepatosplenomegaly (HP:0001433)1.91752395
121Neonatal hypoglycemia (HP:0001998)1.90435936
122Glomerulonephritis (HP:0000099)1.89866589
123Insulin resistance (HP:0000855)1.87799636
124Elevated hepatic transaminases (HP:0002910)1.87033837
125Opisthotonus (HP:0002179)1.86273304
126Increased purine levels (HP:0004368)1.84561044
127Hyperuricemia (HP:0002149)1.84561044
128Increased mean platelet volume (HP:0011877)1.80577199
129Methylmalonic aciduria (HP:0012120)1.80437291
130Lymphangioma (HP:0100764)1.79390397
131Proximal tubulopathy (HP:0000114)1.79246726
132Abnormality of the gallbladder (HP:0005264)1.79229055
133Pigmentary retinal degeneration (HP:0001146)1.79129450
134Hepatic necrosis (HP:0002605)1.78946925
135Symptomatic seizures (HP:0011145)1.78608190
136Nephritis (HP:0000123)1.78228036
137Renal Fanconi syndrome (HP:0001994)1.77890813
138Accelerated skeletal maturation (HP:0005616)1.77767365
139Polygenic inheritance (HP:0010982)1.74919642
140Conjunctival hamartoma (HP:0100780)1.73799626
141Multiple lipomas (HP:0001012)1.73552272
142Atrioventricular block (HP:0001678)1.72477519
143Gowers sign (HP:0003391)1.71697388
144Polar cataract (HP:0010696)1.69834979
145Spinal rigidity (HP:0003306)1.69579867
146Epiphyseal stippling (HP:0010655)1.67900696
147Cerebral inclusion bodies (HP:0100314)1.67346597
148Hyperparathyroidism (HP:0000843)1.67295094
149Lipoatrophy (HP:0100578)1.67085394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.51455827
2SIK15.87945234
3CAMK1D5.10875376
4TRIB33.64608963
5CAMK1G3.63825049
6ERN13.29118838
7FGFR42.71918543
8INSRR2.55183853
9TESK12.53289929
10DDR22.42669041
11ARAF2.38343913
12PDK42.26615128
13PDK32.26615128
14PKN22.14280371
15PRKAA21.93901007
16MST1R1.84612055
17PRPF4B1.55539053
18GRK51.47452567
19MAP2K41.47220772
20ERBB41.47142874
21FGFR21.42624259
22LATS11.40157267
23CAMKK21.37127880
24MAPKAPK31.35493051
25FLT31.33744050
26PDK21.32684945
27RIPK11.32359390
28MAPK111.32037798
29FRK1.29006355
30PIM21.28736271
31TIE11.14291819
32TAOK31.12873733
33DAPK21.11685408
34PIK3CG1.11545124
35ILK1.11309796
36NEK91.06011516
37PINK11.05925017
38LMTK21.04659663
39PIK3CA1.02467629
40PRKAA10.99447488
41PTK60.98640131
42JAK20.97321382
43JAK10.94169052
44ADRBK10.93527720
45TGFBR20.91892141
46MAP3K70.90773372
47MOS0.90337307
48FGFR30.85130548
49TYK20.84388022
50ABL20.83201447
51IRAK30.83089030
52RIPK40.83024688
53MET0.82365037
54MAPK120.81530520
55LRRK20.81306247
56KDR0.81304888
57EEF2K0.80964597
58PRKACG0.79305100
59CDK60.77472420
60PDPK10.73389376
61GSK3A0.70352086
62MAP2K10.67525111
63SCYL20.65940588
64NLK0.64315687
65MAPK40.63267438
66RET0.62969802
67STK38L0.62589067
68PRKCZ0.62432036
69MAPK30.61901205
70DAPK30.60645641
71EPHB10.58913128
72MAP2K30.58176591
73IGF1R0.57914594
74PHKG10.56627747
75PHKG20.56627747
76PDK10.53493898
77SGK30.52045567
78TBK10.51277433
79MAP3K60.49977282
80GRK60.48909636
81PAK20.48739902
82KSR20.47631284
83MAP3K140.47099428
84BRAF0.46750139
85PRKG10.46631271
86EPHA30.46542291
87CAMKK10.43481545
88MAP3K30.43294823
89MYLK0.43028578
90TYRO30.42947077
91PDGFRA0.42806578
92CSK0.42452046
93SGK4940.42361743
94SGK2230.42361743
95CDK90.41550367
96ABL10.40768457
97MTOR0.40530495
98PDGFRB0.39913490
99CAMK10.39690666
100KIT0.38409890
101SGK20.38017846
102PAK10.37608239
103IRAK10.37391862
104PKN10.36747426
105CAMK2G0.36371816
106EPHB20.36251796
107TRPM70.36192937
108PRKD10.34392482
109CSF1R0.34381434
110FER0.34341792
111EIF2AK20.33201986
112MAPK70.32843560
113YES10.32790826
114MAPKAPK50.32744848
115AKT20.32139360
116DYRK1B0.31720200
117LATS20.31595553
118RPS6KA30.31199393
119MAP3K130.31091693
120FGFR10.30034267
121STK160.29734392
122CDK40.29555151
123ERBB20.29314347
124PRKCH0.29273638
125MAP2K60.27232648
126SRC0.27009152
127ZAP700.26839816
128IRAK20.26182803
129PRKACA0.25106109
130EPHA40.25050195
131BMX0.23988665
132PRKACB0.23259427
133CSNK1G10.23050017
134PRKCQ0.22907825
135PTK20.22735565
136TNK20.21876197
137STK380.20938222
138JAK30.20319504
139PTK2B0.19695714
140INSR0.19560779
141PRKCA0.18627046

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.70146586
2Nitrogen metabolism_Homo sapiens_hsa009103.33666179
3Propanoate metabolism_Homo sapiens_hsa006403.00959164
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.93394500
5Fatty acid degradation_Homo sapiens_hsa000712.89540109
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.89287080
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78820892
8Fatty acid metabolism_Homo sapiens_hsa012122.71520325
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70653151
10Arginine biosynthesis_Homo sapiens_hsa002202.59280878
11PPAR signaling pathway_Homo sapiens_hsa033202.58603618
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.55045980
13Fatty acid biosynthesis_Homo sapiens_hsa000612.47399716
14Tryptophan metabolism_Homo sapiens_hsa003802.42204007
15Butanoate metabolism_Homo sapiens_hsa006502.21196949
16Complement and coagulation cascades_Homo sapiens_hsa046102.19178135
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12826966
18Caffeine metabolism_Homo sapiens_hsa002322.11273573
19Peroxisome_Homo sapiens_hsa041462.10616348
20Pyruvate metabolism_Homo sapiens_hsa006202.01197545
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97778740
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94003728
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88613612
24beta-Alanine metabolism_Homo sapiens_hsa004101.82782849
25Fatty acid elongation_Homo sapiens_hsa000621.70075034
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69264272
27Chemical carcinogenesis_Homo sapiens_hsa052041.68950375
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.60243526
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57330128
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54584414
31Histidine metabolism_Homo sapiens_hsa003401.53715052
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50848631
33Carbon metabolism_Homo sapiens_hsa012001.50701738
34Staphylococcus aureus infection_Homo sapiens_hsa051501.50598477
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.47097571
36Phenylalanine metabolism_Homo sapiens_hsa003601.44975149
37Retinol metabolism_Homo sapiens_hsa008301.42557680
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41030733
39Tyrosine metabolism_Homo sapiens_hsa003501.36970589
40Fat digestion and absorption_Homo sapiens_hsa049751.34015118
41Glycerolipid metabolism_Homo sapiens_hsa005611.29790912
42Bile secretion_Homo sapiens_hsa049761.26000851
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23658354
44Starch and sucrose metabolism_Homo sapiens_hsa005001.22519708
45Sulfur metabolism_Homo sapiens_hsa009201.20094169
46Biosynthesis of amino acids_Homo sapiens_hsa012301.17557715
47Selenocompound metabolism_Homo sapiens_hsa004501.08314989
48ABC transporters_Homo sapiens_hsa020101.06153849
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02444665
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00211311
51Vitamin B6 metabolism_Homo sapiens_hsa007500.97470582
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.95990911
53Steroid biosynthesis_Homo sapiens_hsa001000.94349532
54Folate biosynthesis_Homo sapiens_hsa007900.85832364
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81067794
56Pentose phosphate pathway_Homo sapiens_hsa000300.78466376
57Sulfur relay system_Homo sapiens_hsa041220.77659804
58Lysine degradation_Homo sapiens_hsa003100.74814785
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74496341
60Arginine and proline metabolism_Homo sapiens_hsa003300.73709039
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72841711
62Vitamin digestion and absorption_Homo sapiens_hsa049770.67784753
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.64643919
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.61371934
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.61278870
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55618115
67Glutathione metabolism_Homo sapiens_hsa004800.54354865
68Insulin resistance_Homo sapiens_hsa049310.48776609
69AMPK signaling pathway_Homo sapiens_hsa041520.48417209
70Metabolic pathways_Homo sapiens_hsa011000.46549900
71Galactose metabolism_Homo sapiens_hsa000520.38120560
72Glucagon signaling pathway_Homo sapiens_hsa049220.37993982
73Fructose and mannose metabolism_Homo sapiens_hsa000510.37036262
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36334866
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.36139034
76Renin secretion_Homo sapiens_hsa049240.27941334
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27136520
78Insulin signaling pathway_Homo sapiens_hsa049100.24822329
79One carbon pool by folate_Homo sapiens_hsa006700.24425372
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24394192
81ECM-receptor interaction_Homo sapiens_hsa045120.22751996
82Linoleic acid metabolism_Homo sapiens_hsa005910.22333038
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17260082
84Prion diseases_Homo sapiens_hsa050200.16672423
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.07468919
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.07411413
87Malaria_Homo sapiens_hsa051440.04400024
88Ether lipid metabolism_Homo sapiens_hsa00565-0.2279008
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.2181676
90Amoebiasis_Homo sapiens_hsa05146-0.2156982
91Protein digestion and absorption_Homo sapiens_hsa04974-0.2126402
92Renin-angiotensin system_Homo sapiens_hsa04614-0.2111993
93Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2010360
94Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1936057
95Hepatitis C_Homo sapiens_hsa05160-0.1876219
96Circadian rhythm_Homo sapiens_hsa04710-0.1857218
97African trypanosomiasis_Homo sapiens_hsa05143-0.1633973
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1450670
99cGMP-PKG signaling pathway_Homo sapiens_hsa04022-0.1330295
100Dilated cardiomyopathy_Homo sapiens_hsa05414-0.1227247
101Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1226430
102Pertussis_Homo sapiens_hsa05133-0.1205796
103Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1159527
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1076215
105Oxidative phosphorylation_Homo sapiens_hsa00190-0.0858103
106Acute myeloid leukemia_Homo sapiens_hsa05221-0.0802897
107Type II diabetes mellitus_Homo sapiens_hsa04930-0.0714536
108Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0683921
109Alzheimers disease_Homo sapiens_hsa05010-0.0638915
110Parkinsons disease_Homo sapiens_hsa05012-0.0622178
111Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0496519
112Focal adhesion_Homo sapiens_hsa04510-0.0410893
113Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0398496
114Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0091716

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