THEMIS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)8.84884762
2regulation of gamma-delta T cell differentiation (GO:0045586)7.99917155
3negative thymic T cell selection (GO:0045060)7.59635695
4* negative T cell selection (GO:0043383)7.59635695
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.59272169
6negative regulation of cell killing (GO:0031342)7.59272169
7activated T cell proliferation (GO:0050798)7.50587722
8regulation of gamma-delta T cell activation (GO:0046643)7.33110401
9V(D)J recombination (GO:0033151)7.26068180
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)7.11298757
11* positive T cell selection (GO:0043368)7.05272979
12interferon-gamma production (GO:0032609)7.05081955
13positive thymic T cell selection (GO:0045059)6.89074923
14* T cell selection (GO:0045058)6.64926278
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.61916516
16regulation of isotype switching to IgG isotypes (GO:0048302)6.61266988
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.57640365
18thymic T cell selection (GO:0045061)6.36119969
19negative regulation of thymocyte apoptotic process (GO:0070244)6.08184832
20* T cell receptor signaling pathway (GO:0050852)5.74621913
21response to interleukin-15 (GO:0070672)5.61631734
22alpha-beta T cell differentiation (GO:0046632)5.36828117
23cellular response to interleukin-15 (GO:0071350)5.28621404
24regulation of interleukin-2 biosynthetic process (GO:0045076)5.27183791
25T cell costimulation (GO:0031295)5.14682103
26alpha-beta T cell activation (GO:0046631)5.13888195
27lymphocyte costimulation (GO:0031294)5.06306345
28T cell differentiation (GO:0030217)5.03017745
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.97426839
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.97426839
31positive regulation of interleukin-2 production (GO:0032743)4.87545804
32T cell migration (GO:0072678)4.78132794
33positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.77191014
34positive regulation of natural killer cell mediated immunity (GO:0002717)4.77191014
35cytidine metabolic process (GO:0046087)4.69110039
36cytidine catabolic process (GO:0006216)4.69110039
37cytidine deamination (GO:0009972)4.69110039
38* antigen receptor-mediated signaling pathway (GO:0050851)4.61673430
39positive regulation of isotype switching (GO:0045830)4.55984597
40regulation of T cell receptor signaling pathway (GO:0050856)4.50809104
41pyrimidine ribonucleoside catabolic process (GO:0046133)4.49437363
42regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.46219011
43regulation of natural killer cell mediated immunity (GO:0002715)4.46219011
44regulation of T cell tolerance induction (GO:0002664)4.44066599
45positive regulation of alpha-beta T cell proliferation (GO:0046641)4.33798507
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.33221693
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.32505804
48regulation of alpha-beta T cell proliferation (GO:0046640)4.28179984
49regulation of regulatory T cell differentiation (GO:0045589)4.25665903
50negative regulation of T cell mediated immunity (GO:0002710)4.20557215
51mast cell activation (GO:0045576)4.17275447
52regulation of B cell receptor signaling pathway (GO:0050855)4.16530367
53regulation of T cell mediated cytotoxicity (GO:0001914)4.12165568
54regulation of thymocyte apoptotic process (GO:0070243)4.10053463
55antigen processing and presentation of endogenous antigen (GO:0019883)4.09736243
56regulation of B cell differentiation (GO:0045577)4.07484886
57positive regulation of DNA recombination (GO:0045911)4.07273684
58T cell activation (GO:0042110)4.00120100
59positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.97992310
60leukocyte aggregation (GO:0070486)3.97708541
61positive regulation of T cell mediated cytotoxicity (GO:0001916)3.97705391
62regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.91929226
63positive regulation of cell killing (GO:0031343)3.89815456
64regulation of interleukin-2 production (GO:0032663)3.87589706
65tolerance induction (GO:0002507)3.85442788
66T cell homeostasis (GO:0043029)3.82595296
67negative regulation of T cell apoptotic process (GO:0070233)3.79398089
68regulation of isotype switching (GO:0045191)3.78411391
69positive regulation of calcium-mediated signaling (GO:0050850)3.75221954
70positive regulation of B cell mediated immunity (GO:0002714)3.74720089
71positive regulation of immunoglobulin mediated immune response (GO:0002891)3.74720089
72DNA deamination (GO:0045006)3.73078390
73antigen processing and presentation via MHC class Ib (GO:0002475)3.69426924
74somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.68965590
75somatic cell DNA recombination (GO:0016444)3.68965590
76regulation of leukocyte mediated cytotoxicity (GO:0001910)3.68498741
77CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.68353187
78positive regulation of B cell differentiation (GO:0045579)3.66047090
79T cell proliferation (GO:0042098)3.64371249
80positive regulation of humoral immune response (GO:0002922)3.63746961
81regulation of defense response to virus by virus (GO:0050690)3.61020110
82regulation of cell killing (GO:0031341)3.59245298
83mucosal-associated lymphoid tissue development (GO:0048537)3.59038506
84Peyers patch development (GO:0048541)3.59038506
85modulation by virus of host process (GO:0019054)3.56216961
86regulation of interleukin-12 biosynthetic process (GO:0045075)3.56001359
87negative regulation of leukocyte mediated immunity (GO:0002704)3.54619660
88B cell receptor signaling pathway (GO:0050853)3.53625035
89positive regulation of tolerance induction (GO:0002645)3.53587503
90T-helper cell differentiation (GO:0042093)3.50476512
91CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.50476512
92lymphocyte differentiation (GO:0030098)3.45815221
93T cell differentiation involved in immune response (GO:0002292)3.45737191
94alpha-beta T cell differentiation involved in immune response (GO:0002293)3.45737191
95alpha-beta T cell activation involved in immune response (GO:0002287)3.45737191
96positive regulation of natural killer cell differentiation (GO:0032825)3.38276473
97negative regulation of T cell receptor signaling pathway (GO:0050860)3.35725061
98somatic diversification of immune receptors (GO:0002200)3.35536782
99regulation of granulocyte differentiation (GO:0030852)3.35474737
100CD4-positive, alpha-beta T cell activation (GO:0035710)3.34241834
101hepatocyte apoptotic process (GO:0097284)3.33286824
102regulation of immunoglobulin mediated immune response (GO:0002889)3.28656980
103positive regulation of T cell differentiation in thymus (GO:0033089)3.26621277
104mast cell activation involved in immune response (GO:0002279)3.25464934
105mast cell degranulation (GO:0043303)3.25464934
106negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.25323024
107lymphocyte migration (GO:0072676)3.24915141
108positive regulation of T cell activation (GO:0050870)3.23480168
109lymphocyte homeostasis (GO:0002260)3.22838358
110regulation of alpha-beta T cell activation (GO:0046634)3.21251149
111positive regulation of granulocyte differentiation (GO:0030854)3.19979888
112negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.17653707
113regulation of B cell mediated immunity (GO:0002712)3.15671202
114negative regulation of lymphocyte mediated immunity (GO:0002707)3.15600664
115negative regulation of adaptive immune response (GO:0002820)3.14227911
116positive regulation of interleukin-4 production (GO:0032753)3.14074381
117positive regulation of lymphocyte mediated immunity (GO:0002708)3.13135632
118regulation of response to interferon-gamma (GO:0060330)3.13015997
119dendritic cell chemotaxis (GO:0002407)3.12038006
120modulation by symbiont of host cellular process (GO:0044068)3.11847194
121positive regulation of alpha-beta T cell activation (GO:0046635)3.11414036
122regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.10943015
123* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.09530264
124regulation of tolerance induction (GO:0002643)3.09023234
125lymph node development (GO:0048535)3.08065430
126dendritic cell migration (GO:0036336)3.07945703
127positive regulation of T cell mediated immunity (GO:0002711)3.02840582
128cellular defense response (GO:0006968)3.01807054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.50110551
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.02492876
3E2F7_22180533_ChIP-Seq_HELA_Human4.86506175
4RUNX_20019798_ChIP-Seq_JUKART_Human4.31930033
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.09896252
6FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse4.05603955
7MYB_26560356_Chip-Seq_TH2_Human3.65658942
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.58904061
9MYC_22102868_ChIP-Seq_BL_Human3.41309562
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.33518076
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.29343141
12IRF8_22096565_ChIP-ChIP_GC-B_Human3.24627087
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12628416
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.94149399
15MAF_26560356_Chip-Seq_TH1_Human2.83387249
16MYB_26560356_Chip-Seq_TH1_Human2.76667450
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.73611388
18* UTX_26944678_Chip-Seq_JUKART_Human2.73252664
19GATA3_27048872_Chip-Seq_THYMUS_Human2.45392184
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34221871
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27638030
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23852187
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16025680
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.04841892
25VDR_21846776_ChIP-Seq_THP-1_Human1.96968570
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96901172
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.96791704
28TCF7_22412390_ChIP-Seq_EML_Mouse1.91885331
29MAF_26560356_Chip-Seq_TH2_Human1.91026238
30RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.85847076
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.81537018
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.81004367
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.78130461
34SCL_19346495_ChIP-Seq_HPC-7_Human1.77418020
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76477457
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75572410
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72462667
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.71839839
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.69786924
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62455591
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60011588
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59886875
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56522662
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.56481360
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56378308
46SPI1_23547873_ChIP-Seq_NB4_Human1.54069786
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53543206
48VDR_24763502_ChIP-Seq_THP-1_Human1.52365120
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49816068
50KDM2B_26808549_Chip-Seq_DND41_Human1.48747241
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46439313
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40989397
53CIITA_25753668_ChIP-Seq_RAJI_Human1.39700725
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36362386
55GATA3_26560356_Chip-Seq_TH2_Human1.31016893
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.26557842
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21821832
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20473173
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18506503
60SPI1_23127762_ChIP-Seq_K562_Human1.15732253
61PU_27001747_Chip-Seq_BMDM_Mouse1.15032314
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13356008
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10988209
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08262453
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06605634
66VDR_23849224_ChIP-Seq_CD4+_Human1.04907516
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.02671875
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01286579
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00236918
70FOXP3_21729870_ChIP-Seq_TREG_Human0.99607581
71KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96935990
72ELK1_19687146_ChIP-ChIP_HELA_Human0.95074457
73GATA1_22025678_ChIP-Seq_K562_Human0.92832999
74ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91808861
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90516075
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89513443
77SMRT_27268052_Chip-Seq_Bcells_Human0.89247265
78PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88599807
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88568428
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.86725749
81HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86365768
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84397577
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84209342
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84162790
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82882195
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79408458
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79130444
88* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78380866
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78285705
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77664196
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.75836641
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75763600
93TP63_19390658_ChIP-ChIP_HaCaT_Human0.73764670
94GATA1_19941826_ChIP-Seq_K562_Human0.72388971
95AR_21572438_ChIP-Seq_LNCaP_Human0.72041518
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70854418
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70094705
98VDR_24787735_ChIP-Seq_THP-1_Human0.69638371
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69374987
100* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.68654218
101RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.66964546
102GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.66906513
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66761581
104RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66519231
105ETS1_22383799_ChIP-Seq_G1ME_Mouse0.65750229
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.64216543
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.64165718
108SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.63829490
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.63517351
110NCOR1_26117541_ChIP-Seq_K562_Human0.62224856
111GATA2_19941826_ChIP-Seq_K562_Human0.60669231
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60475046
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.60393951
114PKCTHETA_26484144_Chip-Seq_BREAST_Human0.60162017
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60084012
116GATA3_26560356_Chip-Seq_TH1_Human0.59710805
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.59357409
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.58820110
119* PRDM14_20953172_ChIP-Seq_ESCs_Human0.56860023
120E2F1_21310950_ChIP-Seq_MCF-7_Human0.56654019
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.56025291
122KDM5A_27292631_Chip-Seq_BREAST_Human0.54370865
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.54260116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.22956363
2MP0005671_abnormal_response_to4.79497388
3MP0002166_altered_tumor_susceptibility3.78952860
4MP0000685_abnormal_immune_system3.54298660
5* MP0000703_abnormal_thymus_morphology3.43116738
6MP0002006_tumorigenesis3.17189369
7MP0009333_abnormal_splenocyte_physiolog2.97275045
8MP0001835_abnormal_antigen_presentation2.89321514
9MP0002132_abnormal_respiratory_system2.88481533
10MP0009785_altered_susceptibility_to2.84877525
11* MP0002398_abnormal_bone_marrow2.82581331
12MP0001800_abnormal_humoral_immune2.79562208
13MP0005387_immune_system_phenotype2.75974569
14MP0001790_abnormal_immune_system2.75974569
15MP0005000_abnormal_immune_tolerance2.65615103
16MP0002405_respiratory_system_inflammati2.58632864
17* MP0002420_abnormal_adaptive_immunity2.56311850
18MP0010155_abnormal_intestine_physiology2.53909376
19* MP0001819_abnormal_immune_cell2.51354530
20MP0002723_abnormal_immune_serum2.50276268
21MP0006082_CNS_inflammation2.47440362
22MP0002722_abnormal_immune_system2.46216912
23MP0004947_skin_inflammation2.39355473
24* MP0000716_abnormal_immune_system2.39028075
25MP0002933_joint_inflammation2.24606156
26MP0005409_darkened_coat_color2.23164878
27MP0002452_abnormal_antigen_presenting2.17741995
28* MP0000689_abnormal_spleen_morphology2.16140379
29MP0005025_abnormal_response_to2.12195442
30MP0003436_decreased_susceptibility_to1.94999922
31MP0002148_abnormal_hypersensitivity_rea1.93923818
32MP0003866_abnormal_defecation1.93121227
33MP0003300_gastrointestinal_ulcer1.91348279
34MP0004381_abnormal_hair_follicle1.91216805
35* MP0002429_abnormal_blood_cell1.90681006
36MP0001873_stomach_inflammation1.82968444
37MP0002396_abnormal_hematopoietic_system1.81734293
38MP0004808_abnormal_hematopoietic_stem1.80182290
39MP0003724_increased_susceptibility_to1.60091927
40MP0010094_abnormal_chromosome_stability1.58157715
41MP0001845_abnormal_inflammatory_respons1.56279610
42MP0000858_altered_metastatic_potential1.52413591
43MP0000015_abnormal_ear_pigmentation1.50982342
44MP0002009_preneoplasia1.49119122
45MP0002419_abnormal_innate_immunity1.47407395
46MP0005174_abnormal_tail_pigmentation1.43855093
47MP0001853_heart_inflammation1.36679595
48MP0000569_abnormal_digit_pigmentation1.31197582
49MP0005464_abnormal_platelet_physiology1.30112267
50MP0002095_abnormal_skin_pigmentation1.28702512
51MP0005397_hematopoietic_system_phenotyp1.18304519
52MP0001545_abnormal_hematopoietic_system1.18304519
53MP0002163_abnormal_gland_morphology1.17815296
54MP0005075_abnormal_melanosome_morpholog1.15638960
55MP0002277_abnormal_respiratory_mucosa1.15292989
56MP0000490_abnormal_crypts_of1.15055665
57MP0003448_altered_tumor_morphology1.14808293
58MP0009278_abnormal_bone_marrow1.14097403
59MP0005310_abnormal_salivary_gland1.11204501
60MP0002019_abnormal_tumor_incidence1.10368423
61MP0004130_abnormal_muscle_cell1.08332685
62MP0002998_abnormal_bone_remodeling1.04046089
63MP0001849_ear_inflammation1.03114501
64MP0008007_abnormal_cellular_replicative0.94950682
65MP0008057_abnormal_DNA_replication0.93832618
66MP0008260_abnormal_autophagy0.85197482
67MP0001919_abnormal_reproductive_system0.83444037
68MP0000465_gastrointestinal_hemorrhage0.82793914
69MP0008469_abnormal_protein_level0.80961243
70MP0008058_abnormal_DNA_repair0.80172242
71MP0001243_abnormal_dermal_layer0.79607277
72MP0004510_myositis0.78761113
73MP0003077_abnormal_cell_cycle0.78098195
74MP0004883_abnormal_blood_vessel0.77047542
75MP0001851_eye_inflammation0.76874242
76MP0010352_gastrointestinal_tract_polyps0.76507607
77MP0003787_abnormal_imprinting0.76225694
78MP0001348_abnormal_lacrimal_gland0.75288483
79MP0002693_abnormal_pancreas_physiology0.74864360
80MP0003303_peritoneal_inflammation0.70500963
81MP0005451_abnormal_body_composition0.70428373
82MP0001533_abnormal_skeleton_physiology0.69553511
83MP0008569_lethality_at_weaning0.66342548
84MP0001663_abnormal_digestive_system0.65784479
85MP0002075_abnormal_coat/hair_pigmentati0.65281966
86MP0005076_abnormal_cell_differentiation0.65152958
87MP0001191_abnormal_skin_condition0.65123440
88MP0001765_abnormal_ion_homeostasis0.65035853
89MP0003172_abnormal_lysosome_physiology0.64404459
90MP0000383_abnormal_hair_follicle0.62877358
91MP0005379_endocrine/exocrine_gland_phen0.62524859
92MP0003786_premature_aging0.61620010
93MP0009765_abnormal_xenobiotic_induced0.61030650
94MP0008961_abnormal_basal_metabolism0.59071822
95MP0003252_abnormal_bile_duct0.58492407
96MP0003693_abnormal_embryo_hatching0.57630711
97MP0004185_abnormal_adipocyte_glucose0.56340378
98MP0001501_abnormal_sleep_pattern0.54147766
99MP0008873_increased_physiological_sensi0.52380007
100MP0008877_abnormal_DNA_methylation0.51417532
101MP0000627_abnormal_mammary_gland0.51136701
102MP0002138_abnormal_hepatobiliary_system0.50680742
103MP0001186_pigmentation_phenotype0.49930835
104MP0003959_abnormal_lean_body0.49587994
105MP0003045_fibrosis0.49067118
106MP0000604_amyloidosis0.48132874
107MP0000477_abnormal_intestine_morphology0.47969748
108MP0008770_decreased_survivor_rate0.47669868
109MP0003111_abnormal_nucleus_morphology0.47503111
110MP0003795_abnormal_bone_structure0.47468557
111MP0000367_abnormal_coat/_hair0.46568384
112MP0000609_abnormal_liver_physiology0.45970015
113MP0004142_abnormal_muscle_tone0.45854868
114MP0008995_early_reproductive_senescence0.45504775
115MP0001216_abnormal_epidermal_layer0.44844538
116MP0009763_increased_sensitivity_to0.43609849
117MP0000372_irregular_coat_pigmentation0.43056315
118MP0002083_premature_death0.42454597
119MP0001986_abnormal_taste_sensitivity0.42327244
120MP0009764_decreased_sensitivity_to0.41658457
121MP0000249_abnormal_blood_vessel0.40476299
122MP0002136_abnormal_kidney_physiology0.40393523
123MP0003690_abnormal_glial_cell0.39967252
124MP0000350_abnormal_cell_proliferation0.38860322
125MP0008872_abnormal_physiological_respon0.38596039
126MP0000920_abnormal_myelination0.38364470
127MP0005166_decreased_susceptibility_to0.38297620
128MP0005390_skeleton_phenotype0.37996544
129MP0005645_abnormal_hypothalamus_physiol0.37189137

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)8.26052220
2B lymphocytopenia (HP:0010976)7.89786091
3Abnormality of B cell number (HP:0010975)7.89786091
4Combined immunodeficiency (HP:0005387)7.41091542
5Panhypogammaglobulinemia (HP:0003139)7.21188646
6Thyroiditis (HP:0100646)7.07849090
7Hypoplasia of the thymus (HP:0000778)7.06335734
8Eosinophilia (HP:0001880)6.31113404
9Abnormality of T cells (HP:0002843)6.18840282
10Recurrent viral infections (HP:0004429)6.06323878
11Abnormality of eosinophils (HP:0001879)5.42558158
12Granulocytopenia (HP:0001913)5.24955033
13Recurrent fungal infections (HP:0002841)5.05123225
14IgG deficiency (HP:0004315)4.88418760
15Hypoproteinemia (HP:0003075)4.42490316
16Leukocytosis (HP:0001974)4.15769324
17Elevated erythrocyte sedimentation rate (HP:0003565)3.78362659
18Abnormality of the fingertips (HP:0001211)3.66353853
19Recurrent bacterial skin infections (HP:0005406)3.63592047
20Stomatitis (HP:0010280)3.63516644
21Chronic mucocutaneous candidiasis (HP:0002728)3.42075131
22Recurrent cutaneous fungal infections (HP:0011370)3.42075131
23Chronic diarrhea (HP:0002028)3.33229289
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.28428496
25Abnormality of macrophages (HP:0004311)3.14547836
26Myositis (HP:0100614)3.06093540
27Meningitis (HP:0001287)3.04331781
28Nasal polyposis (HP:0100582)3.00970646
29Recurrent bronchitis (HP:0002837)3.00778824
30Autoimmune hemolytic anemia (HP:0001890)2.87571605
31Erythroderma (HP:0001019)2.79659201
32Aplasia/Hypoplasia of the thymus (HP:0010515)2.79348915
33IgM deficiency (HP:0002850)2.77362072
34Joint swelling (HP:0001386)2.76279906
35Chronic otitis media (HP:0000389)2.73003750
36Increased IgM level (HP:0003496)2.72686444
37Lymphoma (HP:0002665)2.71320931
38Retrobulbar optic neuritis (HP:0100654)2.69800437
39Optic neuritis (HP:0100653)2.69800437
40Pustule (HP:0200039)2.64586605
41Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.56684389
42Encephalitis (HP:0002383)2.51178729
43Acute hepatic failure (HP:0006554)2.50571555
44Autoimmune thrombocytopenia (HP:0001973)2.44604063
45Lymphopenia (HP:0001888)2.42908462
46Papilledema (HP:0001085)2.39255695
47Anorexia (HP:0002039)2.37888751
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.34725051
49Abnormality of the nasal mucosa (HP:0000433)2.34419648
50Aplastic anemia (HP:0001915)2.31898088
51Hemoptysis (HP:0002105)2.31589438
52Abnormality of T cell physiology (HP:0011840)2.31132901
53Abnormality of the thymus (HP:0000777)2.28615900
54Orchitis (HP:0100796)2.23642382
55Hypochromic anemia (HP:0001931)2.23400101
56Inflammation of the large intestine (HP:0002037)2.21444329
57Slow saccadic eye movements (HP:0000514)2.21251073
58Recurrent gram-negative bacterial infections (HP:0005420)2.17237965
59Cellular immunodeficiency (HP:0005374)2.15577659
60Eczematoid dermatitis (HP:0000976)2.15552493
61Gastrointestinal inflammation (HP:0004386)2.13224642
62Gingivitis (HP:0000230)2.11464510
63Agammaglobulinemia (HP:0004432)2.11327771
64Keratoconjunctivitis sicca (HP:0001097)2.10063380
65Hemiplegia (HP:0002301)2.09633128
66Gastrointestinal infarctions (HP:0005244)2.05129642
67Abnormality of the pleura (HP:0002103)2.05039310
68Gingival bleeding (HP:0000225)2.02215644
69T lymphocytopenia (HP:0005403)11.1053529
70Abnormality of T cell number (HP:0011839)10.5626893
71Vasculitis (HP:0002633)1.98888946
72Microcytic anemia (HP:0001935)1.96816819
73IgA deficiency (HP:0002720)1.95475212
74Pulmonary infiltrates (HP:0002113)1.94620047
75Basal cell carcinoma (HP:0002671)1.93696900
76Bicuspid aortic valve (HP:0001647)1.93586281
77Urticaria (HP:0001025)1.92936885
78Abnormality of the prostate (HP:0008775)1.92103183
79Arterial thrombosis (HP:0004420)1.89715906
80Keratoconjunctivitis (HP:0001096)1.89610034
81Spontaneous hematomas (HP:0007420)1.89457430
82Glomerulopathy (HP:0100820)1.88150059
83Verrucae (HP:0200043)1.87757336
84Papilloma (HP:0012740)1.87757336
85Bronchiectasis (HP:0002110)1.85333948
86Hypochromic microcytic anemia (HP:0004840)1.84386991
87Cheilitis (HP:0100825)1.82216357
88Recurrent skin infections (HP:0001581)1.81662436
89Mediastinal lymphadenopathy (HP:0100721)1.78000927
90Increased IgE level (HP:0003212)1.77539002
91Abnormal hair whorl (HP:0010721)1.73921289
92Chronic obstructive pulmonary disease (HP:0006510)1.73531465
93Obstructive lung disease (HP:0006536)1.73531465
94Recurrent sinusitis (HP:0011108)1.71958629
95Deep philtrum (HP:0002002)1.71754654
96Hypergammaglobulinemia (HP:0010702)1.70803947
97Ureteral stenosis (HP:0000071)1.70616881
98Polyneuropathy (HP:0001271)1.70362990
99Hematochezia (HP:0002573)1.67449859
100Colitis (HP:0002583)1.65904005
101Alveolar cell carcinoma (HP:0006519)1.63753377
102Bronchitis (HP:0012387)1.62649317
103Volvulus (HP:0002580)1.62367260
104Pulmonary embolism (HP:0002204)1.62293800
105Stomach cancer (HP:0012126)1.62214686
106Recurrent otitis media (HP:0000403)1.59129598
107Ureteral obstruction (HP:0006000)1.57136073
108Sepsis (HP:0100806)1.56838690
109Amaurosis fugax (HP:0100576)1.55112579
110Dislocated radial head (HP:0003083)1.53655125
111Epistaxis (HP:0000421)1.52979144
112Chronic sinusitis (HP:0011109)1.51652578
113Prolonged bleeding time (HP:0003010)1.48522724
114Chest pain (HP:0100749)1.48489028
115Recurrent abscess formation (HP:0002722)1.48238089
116Trigonocephaly (HP:0000243)1.47434396
117Abnormal platelet volume (HP:0011876)1.46304442
118Gangrene (HP:0100758)1.45923553
119Abnormality of oral frenula (HP:0000190)1.45072848
120Abnormality of the radial head (HP:0003995)1.43594140
121Acute lymphatic leukemia (HP:0006721)1.42448650
122Periodontitis (HP:0000704)1.41996822
123Thrombocytosis (HP:0001894)1.40003857
124Keratitis (HP:0000491)1.39735917

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.11028041
2MAP4K15.07772212
3ITK3.82853394
4ZAP703.09429904
5TAOK32.98049901
6JAK32.88630390
7RIPK42.55627294
8NLK2.41497791
9STK102.30690298
10GRK62.24816809
11FGFR42.24795614
12MST42.14422428
13TYK21.98472765
14FGFR31.92870987
15LCK1.91825053
16CSK1.86967920
17KDR1.86642457
18IKBKE1.79845650
19MAP3K141.76515227
20SYK1.73461522
21TEC1.70164336
22YES11.63603028
23HCK1.52379572
24PRKCQ1.45393363
25JAK11.45381917
26CAMKK11.43450069
27MAPK71.39279308
28PDGFRB1.37014908
29BTK1.27580492
30MAP3K71.27461872
31PASK1.26144003
32CLK11.25305534
33CDK121.24970449
34MAP3K101.21539245
35EEF2K1.14995529
36PRKCH1.13179427
37PKN21.10543156
38PIK3CG0.97636315
39GRK70.96907750
40FGFR20.91890231
41MAP3K130.89484078
42NME20.88054159
43PIM10.85419985
44MAP2K60.81927077
45TSSK60.81884601
46TNK20.80630451
47JAK20.80491745
48STK40.79558216
49MAP2K30.78709092
50IRAK40.77800422
51MARK20.77556940
52CSNK1A1L0.77084311
53TBK10.75779723
54NEK60.75487817
55MAP3K110.73938498
56LRRK20.73260493
57BRD40.70247934
58IKBKB0.70006212
59MELK0.69637441
60SIK20.67793473
61FRK0.67477453
62MAP3K120.67268478
63MARK30.66715694
64HIPK20.66696679
65CSF1R0.66278226
66CAMKK20.65963406
67WNK10.65688347
68PRPF4B0.65499951
69CDK90.64861463
70FGR0.64674328
71TYRO30.62097630
72RPS6KA40.62068874
73CDK40.61049367
74EPHA30.57185330
75SIK30.57050509
76MAPK120.57013051
77NUAK10.56679251
78CHUK0.56499415
79CDK60.56467201
80LYN0.56416993
81MAPK40.55803789
82MAP3K10.55301490
83BMPR20.53561089
84CDC70.52607605
85INSR0.51920045
86MKNK20.51615631
87SGK30.51556932
88EPHB10.50700253
89GRK50.49469933
90FES0.49422627
91KIT0.49190904
92FLT30.48265622
93CDK30.48094424
94RAF10.47450945
95ADRBK20.47332422
96RPS6KB20.46912519
97MAP3K30.46659952
98FYN0.46434733
99CSNK1G30.46209809
100PRKD20.43661237
101NTRK20.42431459
102TLK10.42066294
103CSNK1G10.41285292
104FGFR10.39544302
105PDK10.39533807
106STK380.39385615
107TRPM70.36837189
108STK110.36325708
109PIK3CA0.36320483
110IGF1R0.34873453
111PTK60.34585434
112RPS6KA50.34498017
113ATR0.34309287
114TAOK10.33712022
115CSNK1G20.33475875
116MAPK110.33323658
117MAPK30.33168052
118TGFBR20.31154811
119IRAK10.31047404
120KSR20.30429123
121ALK0.30299028
122NEK20.28353779
123BLK0.27733265
124CAMK40.27708777
125EGFR0.27674581
126DMPK0.26798462
127WNK40.25641862
128TESK20.25366881
129ATM0.25025096
130SGK20.24887971
131CHEK10.24661846
132MAP3K80.23530657

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.99326687
2T cell receptor signaling pathway_Homo sapiens_hsa046604.45526707
3Graft-versus-host disease_Homo sapiens_hsa053323.33455691
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.15389186
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.98594565
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.91054724
7Antigen processing and presentation_Homo sapiens_hsa046122.81084255
8Non-homologous end-joining_Homo sapiens_hsa034502.75466143
9Allograft rejection_Homo sapiens_hsa053302.62920494
10Measles_Homo sapiens_hsa051622.58647614
11Hematopoietic cell lineage_Homo sapiens_hsa046402.38473737
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.22533374
13Autoimmune thyroid disease_Homo sapiens_hsa053201.97674639
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.57675428
15Osteoclast differentiation_Homo sapiens_hsa043801.53339129
16Type I diabetes mellitus_Homo sapiens_hsa049401.47862662
17Acute myeloid leukemia_Homo sapiens_hsa052211.41681220
18Viral myocarditis_Homo sapiens_hsa054161.38865353
19Leishmaniasis_Homo sapiens_hsa051401.33516125
20Herpes simplex infection_Homo sapiens_hsa051681.33493172
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31477083
22Chemokine signaling pathway_Homo sapiens_hsa040621.25196154
23B cell receptor signaling pathway_Homo sapiens_hsa046621.20240880
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.17767389
25HTLV-I infection_Homo sapiens_hsa051661.17479299
26Hepatitis B_Homo sapiens_hsa051611.15392197
27Colorectal cancer_Homo sapiens_hsa052101.14266651
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10665651
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09409911
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08213130
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07934930
32Thyroid cancer_Homo sapiens_hsa052161.06726485
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06321379
34Chronic myeloid leukemia_Homo sapiens_hsa052201.05548517
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03493998
36Toxoplasmosis_Homo sapiens_hsa051450.99277764
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98237089
38Influenza A_Homo sapiens_hsa051640.92394553
39TNF signaling pathway_Homo sapiens_hsa046680.85822556
40Viral carcinogenesis_Homo sapiens_hsa052030.82588346
41FoxO signaling pathway_Homo sapiens_hsa040680.81647048
42Endometrial cancer_Homo sapiens_hsa052130.81139133
43Pancreatic cancer_Homo sapiens_hsa052120.78774188
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77682823
45Apoptosis_Homo sapiens_hsa042100.72767723
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69913442
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69784877
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69518708
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69189394
50Epstein-Barr virus infection_Homo sapiens_hsa051690.69015209
51Prostate cancer_Homo sapiens_hsa052150.68713332
52Prolactin signaling pathway_Homo sapiens_hsa049170.66903280
53Shigellosis_Homo sapiens_hsa051310.65113355
54Non-small cell lung cancer_Homo sapiens_hsa052230.64379127
55Asthma_Homo sapiens_hsa053100.64154034
56African trypanosomiasis_Homo sapiens_hsa051430.63814733
57Spliceosome_Homo sapiens_hsa030400.63136880
58Regulation of autophagy_Homo sapiens_hsa041400.62200344
59Rheumatoid arthritis_Homo sapiens_hsa053230.61542335
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60273005
61Platelet activation_Homo sapiens_hsa046110.57324088
62Systemic lupus erythematosus_Homo sapiens_hsa053220.57162760
63Hepatitis C_Homo sapiens_hsa051600.56286299
64p53 signaling pathway_Homo sapiens_hsa041150.56267575
65Notch signaling pathway_Homo sapiens_hsa043300.55990734
66RNA degradation_Homo sapiens_hsa030180.55910173
67Long-term potentiation_Homo sapiens_hsa047200.55203130
68mRNA surveillance pathway_Homo sapiens_hsa030150.51323874
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49593206
70Dorso-ventral axis formation_Homo sapiens_hsa043200.48544776
71Adherens junction_Homo sapiens_hsa045200.48426256
72Malaria_Homo sapiens_hsa051440.46518981
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46499104
74Cell cycle_Homo sapiens_hsa041100.45449176
75Ribosome_Homo sapiens_hsa030100.44734483
76Fanconi anemia pathway_Homo sapiens_hsa034600.44312954
77Lysine degradation_Homo sapiens_hsa003100.44028006
78Staphylococcus aureus infection_Homo sapiens_hsa051500.43203020
79Legionellosis_Homo sapiens_hsa051340.42825770
80DNA replication_Homo sapiens_hsa030300.42680079
81Small cell lung cancer_Homo sapiens_hsa052220.41005506
82Tuberculosis_Homo sapiens_hsa051520.40857391
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.38529328
84MAPK signaling pathway_Homo sapiens_hsa040100.38260453
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.38197519
86Mismatch repair_Homo sapiens_hsa034300.38045593
87MicroRNAs in cancer_Homo sapiens_hsa052060.37832473
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37051064
89Base excision repair_Homo sapiens_hsa034100.36055209
90Salmonella infection_Homo sapiens_hsa051320.35984223
91Glioma_Homo sapiens_hsa052140.35731783
92Ras signaling pathway_Homo sapiens_hsa040140.35543920
93Choline metabolism in cancer_Homo sapiens_hsa052310.35540640
94Alcoholism_Homo sapiens_hsa050340.34797866
95VEGF signaling pathway_Homo sapiens_hsa043700.34700580
96mTOR signaling pathway_Homo sapiens_hsa041500.34650656
97Inositol phosphate metabolism_Homo sapiens_hsa005620.34537091
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34409665
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34034719
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33891051
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32290481
102Renal cell carcinoma_Homo sapiens_hsa052110.31761861
103Circadian rhythm_Homo sapiens_hsa047100.31704241
104Pathways in cancer_Homo sapiens_hsa052000.29778920
105ErbB signaling pathway_Homo sapiens_hsa040120.29567824
106Endocytosis_Homo sapiens_hsa041440.28722131
107Rap1 signaling pathway_Homo sapiens_hsa040150.27542086
108Wnt signaling pathway_Homo sapiens_hsa043100.25922200
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25827146
110Phototransduction_Homo sapiens_hsa047440.25067661
111Cholinergic synapse_Homo sapiens_hsa047250.23692833
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23517065
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23322371
114Pertussis_Homo sapiens_hsa051330.22528982
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.22143766
116Renin secretion_Homo sapiens_hsa049240.21398790
117Linoleic acid metabolism_Homo sapiens_hsa005910.21256357
118Morphine addiction_Homo sapiens_hsa050320.20556536
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.20203843
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20101273
121Insulin resistance_Homo sapiens_hsa049310.19799674
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.18288499
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.17551239
124HIF-1 signaling pathway_Homo sapiens_hsa040660.17499703
125Oxytocin signaling pathway_Homo sapiens_hsa049210.17145211

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