THBS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.24334348
2central nervous system myelination (GO:0022010)7.24334348
3ensheathment of neurons (GO:0007272)5.57955577
4axon ensheathment (GO:0008366)5.57955577
5myelination (GO:0042552)5.55726751
6peripheral nervous system axon ensheathment (GO:0032292)4.92706905
7myelination in peripheral nervous system (GO:0022011)4.92706905
8limb bud formation (GO:0060174)4.88286855
9planar cell polarity pathway involved in neural tube closure (GO:0090179)4.51125684
10axonemal dynein complex assembly (GO:0070286)4.50031454
11negative regulation of neurotransmitter secretion (GO:0046929)4.49121254
12positive regulation of oligodendrocyte differentiation (GO:0048714)4.41411355
13metanephric mesenchyme development (GO:0072075)4.39637515
14oligodendrocyte differentiation (GO:0048709)4.26274370
15apical protein localization (GO:0045176)4.25481227
16virion attachment to host cell (GO:0019062)4.22693851
17adhesion of symbiont to host cell (GO:0044650)4.22693851
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.21219425
19neuron projection extension involved in neuron projection guidance (GO:1902284)4.14600603
20axon extension involved in axon guidance (GO:0048846)4.14600603
21fatty acid elongation (GO:0030497)4.14428754
22kidney mesenchyme development (GO:0072074)4.11840161
23positive regulation of gastrulation (GO:2000543)4.07622851
24astrocyte development (GO:0014002)4.02967775
25protein heterotrimerization (GO:0070208)3.99251398
26collagen fibril organization (GO:0030199)3.94993393
27eye photoreceptor cell differentiation (GO:0001754)3.89377258
28photoreceptor cell differentiation (GO:0046530)3.89377258
29semaphorin-plexin signaling pathway (GO:0071526)3.87397202
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.83116060
31asymmetric protein localization (GO:0008105)3.76351854
32cilium movement (GO:0003341)3.76124751
33chondrocyte development (GO:0002063)3.66494139
34cilium or flagellum-dependent cell motility (GO:0001539)3.66476052
35* cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.58648632
36epithelial cilium movement (GO:0003351)3.58057580
37negative regulation of neurotransmitter transport (GO:0051589)3.46261129
38long-chain fatty acid biosynthetic process (GO:0042759)3.37895257
39peptidyl-tyrosine autophosphorylation (GO:0038083)3.37663673
40cranial nerve morphogenesis (GO:0021602)3.37613701
41adhesion of symbiont to host (GO:0044406)3.36056025
42lateral sprouting from an epithelium (GO:0060601)3.34875824
43urogenital system development (GO:0001655)3.34283855
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.30807248
45presynaptic membrane assembly (GO:0097105)3.29789317
46extracellular fibril organization (GO:0043206)3.28922981
47presynaptic membrane organization (GO:0097090)3.26925942
48cell migration in hindbrain (GO:0021535)3.24132408
49cartilage condensation (GO:0001502)3.23025261
50cell aggregation (GO:0098743)3.23025261
51negative regulation of JUN kinase activity (GO:0043508)3.21217972
52axon extension (GO:0048675)3.20986578
53cerebral cortex radially oriented cell migration (GO:0021799)3.19213459
54regulation of establishment of planar polarity (GO:0090175)3.17834675
55ganglion development (GO:0061548)3.16391920
56myelin maintenance (GO:0043217)3.16104148
57motile cilium assembly (GO:0044458)3.15574602
58camera-type eye morphogenesis (GO:0048593)3.14807190
59establishment of planar polarity (GO:0001736)3.14407226
60establishment of tissue polarity (GO:0007164)3.14407226
61negative regulation of axon extension (GO:0030517)3.10856564
62dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.07944366
63negative regulation of axon extension involved in axon guidance (GO:0048843)3.05172875
64negative regulation of chondrocyte differentiation (GO:0032331)3.03537600
65endothelial cell chemotaxis (GO:0035767)3.03408548
66regulation of ARF GTPase activity (GO:0032312)3.02601206
67embryonic retina morphogenesis in camera-type eye (GO:0060059)3.00012283
68peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.97812040
69facial nerve structural organization (GO:0021612)2.96265490
70cochlea morphogenesis (GO:0090103)2.94374065
71negative regulation of axonogenesis (GO:0050771)2.92479510
72collagen catabolic process (GO:0030574)2.92379461
73cholesterol biosynthetic process (GO:0006695)2.90800053
74response to redox state (GO:0051775)2.90138902
75head development (GO:0060322)2.89317542
76dermatan sulfate metabolic process (GO:0030205)2.89300841
77mannose metabolic process (GO:0006013)2.87234135
78left/right pattern formation (GO:0060972)2.87121365
79cell-cell junction maintenance (GO:0045217)2.86816222
80negative regulation of protein localization to cell surface (GO:2000009)2.86255908
81collagen metabolic process (GO:0032963)2.84880550
82negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.83868161
83positive regulation of glial cell differentiation (GO:0045687)2.83200168
84neuronal ion channel clustering (GO:0045161)2.82426557
85neuron cell-cell adhesion (GO:0007158)2.81575973
86regulation of collateral sprouting (GO:0048670)2.80609573
87* bone trabecula formation (GO:0060346)2.80559154
88embryonic body morphogenesis (GO:0010172)2.80292291
89convergent extension (GO:0060026)2.78168855
90positive regulation of smoothened signaling pathway (GO:0045880)2.77170534
91glomerular filtration (GO:0003094)2.74735191
92multicellular organismal macromolecule metabolic process (GO:0044259)2.74563587
93positive regulation of protein kinase C signaling (GO:0090037)2.72860674
94import into cell (GO:0098657)2.71994650
95positive regulation of neurological system process (GO:0031646)2.71593829
96axonal fasciculation (GO:0007413)2.71210427
97multicellular organismal catabolic process (GO:0044243)2.70665011
98Leydig cell differentiation (GO:0033327)2.68461155
99chondroitin sulfate catabolic process (GO:0030207)2.67833537
100forebrain neuron differentiation (GO:0021879)2.67346559
101interleukin-6-mediated signaling pathway (GO:0070102)2.66471523
102negative regulation of catenin import into nucleus (GO:0035414)2.65799310
103neuron projection extension (GO:1990138)2.65393689
104glial cell development (GO:0021782)2.64616969
105transmission of nerve impulse (GO:0019226)2.64603429
106endothelial cell morphogenesis (GO:0001886)2.64525610
107cranial nerve structural organization (GO:0021604)2.63317026
108non-canonical Wnt signaling pathway (GO:0035567)2.63095393
109substantia nigra development (GO:0021762)2.62836290
110microtubule severing (GO:0051013)2.62279139
111negative regulation of axon guidance (GO:1902668)2.62188876
112short-term memory (GO:0007614)2.60317960
113creatine metabolic process (GO:0006600)2.60038632
114negative regulation of cartilage development (GO:0061037)2.59337470
115cytoskeletal anchoring at plasma membrane (GO:0007016)2.59285774
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55479917
117multicellular organismal metabolic process (GO:0044236)2.55344262
118pyrimidine nucleobase catabolic process (GO:0006208)2.54923050
119skin morphogenesis (GO:0043589)2.54648405
120dendrite morphogenesis (GO:0048813)2.54283363
121regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.54052347
122regulation of oligodendrocyte differentiation (GO:0048713)2.54010682
123mesenchymal-epithelial cell signaling (GO:0060638)2.53770912
124histone H3-K9 demethylation (GO:0033169)2.53468288
125paraxial mesoderm development (GO:0048339)2.53230762
126insulin-like growth factor receptor signaling pathway (GO:0048009)2.51541281
127body morphogenesis (GO:0010171)2.51475743
128negative regulation of fatty acid transport (GO:2000192)2.50204550
129regulation of axon extension involved in axon guidance (GO:0048841)2.49805952
130negative chemotaxis (GO:0050919)2.49611743
131neuron recognition (GO:0008038)2.49366459
132sterol biosynthetic process (GO:0016126)2.48721949
133renal filtration (GO:0097205)2.48471989
134membrane assembly (GO:0071709)2.46403910
135positive regulation of action potential (GO:0045760)2.46374261
136extracellular matrix disassembly (GO:0022617)2.45806197
137vascular endothelial growth factor signaling pathway (GO:0038084)2.45647196
138extracellular matrix assembly (GO:0085029)2.45070081
139pattern specification involved in kidney development (GO:0061004)2.43124595
140eye morphogenesis (GO:0048592)2.42913904
141positive regulation of gliogenesis (GO:0014015)2.42579037
142appendage development (GO:0048736)2.41939857
143limb development (GO:0060173)2.41939857
144positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.40925690
145spinal cord association neuron differentiation (GO:0021527)2.38455513
146embryonic viscerocranium morphogenesis (GO:0048703)2.38416129
147sequestering of extracellular ligand from receptor (GO:0035581)2.38347940
148positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.37878422
149glial cell differentiation (GO:0010001)2.35619560
150establishment of mitochondrion localization (GO:0051654)2.35427084
151atrioventricular valve morphogenesis (GO:0003181)2.35420350
152cell migration involved in heart development (GO:0060973)2.34427744
153isoprenoid biosynthetic process (GO:0008299)2.34047685
154branching involved in salivary gland morphogenesis (GO:0060445)2.32654642
155cellular response to catecholamine stimulus (GO:0071870)2.32404899
156cellular response to monoamine stimulus (GO:0071868)2.32404899
157establishment of monopolar cell polarity (GO:0061162)2.31941319
158establishment or maintenance of monopolar cell polarity (GO:0061339)2.31941319
159somite development (GO:0061053)2.31792660
160replacement ossification (GO:0036075)2.31468287
161endochondral ossification (GO:0001958)2.31468287
162fibril organization (GO:0097435)2.31381144
163regulation of extracellular matrix disassembly (GO:0010715)2.31025841
164regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.30451634
165basement membrane organization (GO:0071711)2.30394908
166dendritic spine morphogenesis (GO:0060997)2.30379688
167cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.28810043
168regulation of axon guidance (GO:1902667)2.28506532
169cellular response to epinephrine stimulus (GO:0071872)2.28130795
170embryonic camera-type eye development (GO:0031076)2.27677056
171syncytium formation by plasma membrane fusion (GO:0000768)2.26989184
172protein palmitoylation (GO:0018345)2.26820035
173lens fiber cell development (GO:0070307)2.26295699
174substrate-dependent cell migration (GO:0006929)2.25149500
175dermatan sulfate biosynthetic process (GO:0030208)2.23989847
176developmental cell growth (GO:0048588)2.23958102
177myoblast fusion (GO:0007520)2.22983688
178keratan sulfate catabolic process (GO:0042340)2.22789813
179regulation of neuron migration (GO:2001222)2.22055781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.59576465
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84919551
3GBX2_23144817_ChIP-Seq_PC3_Human2.82401569
4EZH2_22144423_ChIP-Seq_EOC_Human2.78716478
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.67733105
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.58758188
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53208258
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53208258
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47754227
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45989938
11* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.44647937
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41657691
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36830253
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.30602245
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26493983
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.19821107
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19081447
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17294055
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15005760
20* LXR_22292898_ChIP-Seq_THP-1_Human2.13608816
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13465089
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11897310
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.04436836
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.02423129
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98977891
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98485295
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.97268049
28DROSHA_22980978_ChIP-Seq_HELA_Human1.95906590
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93641505
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90634334
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87530037
32AR_21572438_ChIP-Seq_LNCaP_Human1.84943651
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82307895
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72404376
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68945185
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67880815
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67557689
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.66940847
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.64733783
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63871866
41KDM2B_26808549_Chip-Seq_DND41_Human1.57144487
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56811711
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56611082
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.56582244
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56378453
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52807685
47SMC4_20622854_ChIP-Seq_HELA_Human1.50174602
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49213550
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47634670
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41907013
51RACK7_27058665_Chip-Seq_MCF-7_Human1.41038300
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.40472245
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39058020
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37295180
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.36414888
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35769057
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35650499
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.35274737
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34497703
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.32944545
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31747602
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.30679024
63TP53_18474530_ChIP-ChIP_U2OS_Human1.30610883
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30348446
65TP53_22127205_ChIP-Seq_IMR90_Human1.30110415
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30081761
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.27963148
68CREB1_26743006_Chip-Seq_LNCaP_Human1.27495607
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27385054
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23934933
71* SA1_27219007_Chip-Seq_ERYTHROID_Human1.23430810
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21145618
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20210081
74SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.20133995
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20058809
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19062248
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18962620
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18962620
79TP53_23651856_ChIP-Seq_MEFs_Mouse1.18530186
80* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18159562
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16600459
82P68_20966046_ChIP-Seq_HELA_Human1.16448015
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.16274492
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16114861
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15788675
86CJUN_26792858_Chip-Seq_BT549_Human1.15164698
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14699860
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14537190
89CLOCK_20551151_ChIP-Seq_293T_Human1.12096702
90AHR_22903824_ChIP-Seq_MCF-7_Human1.10290584
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.10149418
92ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10105257
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.09564439
94* TET1_21490601_ChIP-Seq_MESCs_Mouse1.08706881
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07469645
96RARB_27405468_Chip-Seq_BRAIN_Mouse1.06126360
97TP63_22573176_ChIP-Seq_HFKS_Human1.05964029
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.04717138
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.03179252
100KDM2B_26808549_Chip-Seq_K562_Human1.02511510
101SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01614060
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00445661
103* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00306345
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00063708
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00049611
106CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98808350
107* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97811675
108SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97461359
109ER_23166858_ChIP-Seq_MCF-7_Human0.96924916
110* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96853097
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96505242
112TET1_21451524_ChIP-Seq_MESCs_Mouse0.95145534
113RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94967608
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94791854
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94546811
116CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94517617
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94327231
118STAT3_23295773_ChIP-Seq_U87_Human0.94250241
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94056822
120ZNF274_21170338_ChIP-Seq_K562_Hela0.93537615
121TCF7_22412390_ChIP-Seq_EML_Mouse0.93400517
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.91595116
123* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90803414
124TAF15_26573619_Chip-Seq_HEK293_Human0.90289658
125POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89973141
126MYC_27129775_Chip-Seq_CORNEA_Mouse0.89863992
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89356413
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89301077
129CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88486366
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88189562
131CTCF_27219007_Chip-Seq_Bcells_Human0.88183466
132* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88082509
133SMAD4_21799915_ChIP-Seq_A2780_Human0.88032629
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86839836
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86505729
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86030084
137* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84627799
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84597256
139* SOX2_21211035_ChIP-Seq_LN229_Gbm0.84562950
140P300_19829295_ChIP-Seq_ESCs_Human0.84394554
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83835501
142RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83769189
143TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83508283
144TBX20_22328084_ChIP-Seq_HEART_Mouse0.83307559
145TBX20_22080862_ChIP-Seq_HEART_Mouse0.83307559
146RNF2_27304074_Chip-Seq_NSC_Mouse0.83096085
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.82318290
148GATA1_26923725_Chip-Seq_HPCs_Mouse0.82276387
149FUS_26573619_Chip-Seq_HEK293_Human0.82251640
150TCF4_23295773_ChIP-Seq_U87_Human0.82225039
151TP53_16413492_ChIP-PET_HCT116_Human0.82100142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.73197502
2MP0005503_abnormal_tendon_morphology4.37028774
3MP0005275_abnormal_skin_tensile3.29343674
4MP0003705_abnormal_hypodermis_morpholog3.04968230
5MP0004134_abnormal_chest_morphology2.84163385
6MP0000920_abnormal_myelination2.83157308
7MP0001958_emphysema2.44431823
8MP0005623_abnormal_meninges_morphology2.30320833
9MP0004272_abnormal_basement_membrane2.25355374
10MP0001299_abnormal_eye_distance/2.15469063
11MP0004270_analgesia1.99031051
12MP0009250_abnormal_appendicular_skeleto1.98873310
13MP0001849_ear_inflammation1.97056325
14MP0000778_abnormal_nervous_system1.92905390
15MP0000751_myopathy1.87675588
16MP0003880_abnormal_central_pattern1.83256985
17MP0005409_darkened_coat_color1.81168529
18MP0010368_abnormal_lymphatic_system1.79383151
19MP0003283_abnormal_digestive_organ1.78823502
20MP0005508_abnormal_skeleton_morphology1.78673861
21MP0000462_abnormal_digestive_system1.78073718
22MP0003950_abnormal_plasma_membrane1.76432465
23MP0008789_abnormal_olfactory_epithelium1.76259253
24MP0002108_abnormal_muscle_morphology1.74252224
25MP0000762_abnormal_tongue_morphology1.73893170
26MP0004885_abnormal_endolymph1.65116921
27MP0005171_absent_coat_pigmentation1.64350453
28MP0000566_synostosis1.64301820
29MP0004859_abnormal_synaptic_plasticity1.63638629
30MP0010030_abnormal_orbit_morphology1.59454902
31MP0002282_abnormal_trachea_morphology1.57838717
32MP0003937_abnormal_limbs/digits/tail_de1.55339116
33MP0005248_abnormal_Harderian_gland1.53064317
34MP0009780_abnormal_chondrocyte_physiolo1.53033660
35MP0003385_abnormal_body_wall1.48559310
36MP0009384_cardiac_valve_regurgitation1.48325566
37MP0000163_abnormal_cartilage_morphology1.45750206
38MP0004742_abnormal_vestibular_system1.45559228
39MP0002295_abnormal_pulmonary_circulatio1.44366494
40MP0003279_aneurysm1.42985689
41MP0003634_abnormal_glial_cell1.42470392
42MP0002933_joint_inflammation1.40247529
43MP0010386_abnormal_urinary_bladder1.39726576
44MP0005394_taste/olfaction_phenotype1.38241125
45MP0005499_abnormal_olfactory_system1.38241125
46MP0004145_abnormal_muscle_electrophysio1.37670765
47MP0004858_abnormal_nervous_system1.37472679
48MP0005058_abnormal_lysosome_morphology1.37438787
49MP0002896_abnormal_bone_mineralization1.36853567
50MP0000049_abnormal_middle_ear1.35541225
51MP0006276_abnormal_autonomic_nervous1.35252940
52MP0003755_abnormal_palate_morphology1.32231352
53MP0001502_abnormal_circadian_rhythm1.30690097
54MP0005257_abnormal_intraocular_pressure1.29452841
55MP0000767_abnormal_smooth_muscle1.29437651
56MP0000537_abnormal_urethra_morphology1.25507287
57MP0006292_abnormal_olfactory_placode1.19939375
58MP0002116_abnormal_craniofacial_bone1.19180823
59MP0001177_atelectasis1.19119922
60MP0000534_abnormal_ureter_morphology1.18682249
61MP0001188_hyperpigmentation1.18647393
62MP0000428_abnormal_craniofacial_morphol1.16507749
63MP0002233_abnormal_nose_morphology1.15635464
64MP0000003_abnormal_adipose_tissue1.15117550
65MP0003329_amyloid_beta_deposits1.14632953
66MP0000955_abnormal_spinal_cord1.14587184
67MP0004133_heterotaxia1.14138079
68MP0005423_abnormal_somatic_nervous1.13069291
69MP0002234_abnormal_pharynx_morphology1.12727220
70MP0002932_abnormal_joint_morphology1.10242896
71MP0001485_abnormal_pinna_reflex1.09723246
72MP0001879_abnormal_lymphatic_vessel1.09143885
73MP0002734_abnormal_mechanical_nocicepti1.09123418
74MP0001348_abnormal_lacrimal_gland1.07001764
75MP0002822_catalepsy1.06593037
76* MP0002115_abnormal_skeleton_extremities1.06023806
77MP0002184_abnormal_innervation1.03529223
78MP0003690_abnormal_glial_cell1.03368190
79MP0003566_abnormal_cell_adhesion1.02851868
80MP0000733_abnormal_muscle_development1.02095059
81MP0000747_muscle_weakness1.01993941
82MP0000383_abnormal_hair_follicle1.01504684
83MP0003942_abnormal_urinary_system1.01080829
84MP0000538_abnormal_urinary_bladder1.00689100
85MP0002249_abnormal_larynx_morphology0.99151188
86MP0005023_abnormal_wound_healing0.97235980
87MP0002272_abnormal_nervous_system0.96936689
88MP0010678_abnormal_skin_adnexa0.96701622
89MP0003938_abnormal_ear_development0.96472508
90MP0001905_abnormal_dopamine_level0.95835991
91MP0005377_hearing/vestibular/ear_phenot0.94493580
92MP0003878_abnormal_ear_physiology0.94493580
93MP0001346_abnormal_lacrimal_gland0.93097206
94MP0005390_skeleton_phenotype0.93057365
95MP0000467_abnormal_esophagus_morphology0.92742586
96MP0005595_abnormal_vascular_smooth0.92154935
97MP0002882_abnormal_neuron_morphology0.91741803
98MP0002653_abnormal_ependyma_morphology0.91247838
99MP0001486_abnormal_startle_reflex0.91039532
100MP0003635_abnormal_synaptic_transmissio0.90653519
101MP0003122_maternal_imprinting0.90324320
102MP0009053_abnormal_anal_canal0.90092551
103MP0000432_abnormal_head_morphology0.87784558
104MP0004142_abnormal_muscle_tone0.87676974
105MP0000631_abnormal_neuroendocrine_gland0.87404927
106MP0002114_abnormal_axial_skeleton0.86617885
107MP0003172_abnormal_lysosome_physiology0.86188014
108MP0003632_abnormal_nervous_system0.85994101
109MP0003115_abnormal_respiratory_system0.85929524
110MP0001270_distended_abdomen0.84385257
111MP0002064_seizures0.84180013
112MP0003935_abnormal_craniofacial_develop0.83938724
113* MP0002109_abnormal_limb_morphology0.83508057
114* MP0002113_abnormal_skeleton_development0.83169816
115MP0001340_abnormal_eyelid_morphology0.82214077
116MP0003948_abnormal_gas_homeostasis0.80349469
117MP0002060_abnormal_skin_morphology0.79035514
118MP0002133_abnormal_respiratory_system0.79004912
119MP0005388_respiratory_system_phenotype0.79004912
120MP0002752_abnormal_somatic_nervous0.78198837
121MP0001542_abnormal_bone_strength0.78021788
122MP0003861_abnormal_nervous_system0.77925683
123MP0002092_abnormal_eye_morphology0.76296221
124MP0003136_yellow_coat_color0.76184066
125MP0000013_abnormal_adipose_tissue0.74778608
126MP0005410_abnormal_fertilization0.74144530
127MP0006054_spinal_hemorrhage0.74041545
128MP0002938_white_spotting0.73166097
129MP0003091_abnormal_cell_migration0.72846591
130MP0001943_abnormal_respiration0.72373665
131MP0009745_abnormal_behavioral_response0.72272924
132MP0000026_abnormal_inner_ear0.72156528
133MP0002152_abnormal_brain_morphology0.70759589
134MP0003879_abnormal_hair_cell0.68753225
135MP0002697_abnormal_eye_size0.66555827

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.59855372
2Epiphyseal dysplasia (HP:0002656)4.52495777
3Cervical subluxation (HP:0003308)4.15007779
4Hypoplastic ischia (HP:0003175)3.86582314
5Irregular epiphyses (HP:0010582)3.66514981
6Abnormality of the ischium (HP:0003174)3.63119094
7Small epiphyses (HP:0010585)3.62776293
8Protrusio acetabuli (HP:0003179)3.43123638
9Neonatal short-limb short stature (HP:0008921)3.37767042
10Peritonitis (HP:0002586)3.37503789
11Broad metatarsal (HP:0001783)3.36391135
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.35044074
13Genu recurvatum (HP:0002816)3.26092869
14Thin bony cortex (HP:0002753)3.25763030
15Aortic aneurysm (HP:0004942)3.25661250
16Follicular hyperkeratosis (HP:0007502)3.23045174
17Mild short stature (HP:0003502)3.11076723
18Shallow orbits (HP:0000586)3.08421962
19Sensory axonal neuropathy (HP:0003390)3.07441128
20Abnormality of dentin (HP:0010299)3.05154868
21Vitreoretinal degeneration (HP:0000655)3.01314887
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.98961222
23Ankle contracture (HP:0006466)2.96375501
24Joint stiffness (HP:0001387)2.93755839
25Cerebral aneurysm (HP:0004944)2.91379732
26Obstructive sleep apnea (HP:0002870)2.88614010
27Vascular tortuosity (HP:0004948)2.88028886
28Muscle fiber splitting (HP:0003555)2.82284132
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.81834925
30Degeneration of the lateral corticospinal tracts (HP:0002314)2.81834925
31Arterial tortuosity (HP:0005116)2.78034633
32Osteoarthritis (HP:0002758)2.77571140
33Delayed epiphyseal ossification (HP:0002663)2.75383595
34Neurofibrillary tangles (HP:0002185)2.74890932
35Type 1 muscle fiber predominance (HP:0003803)2.73889953
36Abnormal respiratory epithelium morphology (HP:0012253)2.72578143
37Abnormal respiratory motile cilium morphology (HP:0005938)2.72578143
38Overgrowth (HP:0001548)2.69928488
39Abnormal ciliary motility (HP:0012262)2.69183013
40Coronal craniosynostosis (HP:0004440)2.67350225
41Soft skin (HP:0000977)2.65405415
42Abnormal respiratory motile cilium physiology (HP:0012261)2.65326169
43Absent/shortened dynein arms (HP:0200106)2.64661884
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.64661884
45Bladder diverticulum (HP:0000015)2.60769441
46Mitral regurgitation (HP:0001653)2.60520090
47Bell-shaped thorax (HP:0001591)2.59785937
48Biconcave vertebral bodies (HP:0004586)2.59779902
49Cupped ribs (HP:0000887)2.59666152
50Spinal rigidity (HP:0003306)2.58645356
51Short nail (HP:0001799)2.51626417
52Wormian bones (HP:0002645)2.49296013
53Atelectasis (HP:0100750)2.49182380
54Bronchomalacia (HP:0002780)2.45400280
55Infantile muscular hypotonia (HP:0008947)2.45221052
56Occipital encephalocele (HP:0002085)2.45060730
57Thickened helices (HP:0000391)2.43671005
58Abnormality of the phalanges of the 2nd finger (HP:0009541)2.40616261
59Hypoplastic pelvis (HP:0008839)2.40471857
60Atrophic scars (HP:0001075)2.38731042
61Parakeratosis (HP:0001036)2.35820286
62Broad face (HP:0000283)2.35571484
63Aortic dissection (HP:0002647)2.35405133
64Aortic regurgitation (HP:0001659)2.34438840
65Flat capital femoral epiphysis (HP:0003370)2.31499577
66Alacrima (HP:0000522)2.24334943
67Turricephaly (HP:0000262)2.23808106
68Limited hip movement (HP:0008800)2.23730533
69Dilatation of the ascending aorta (HP:0005111)2.22928385
70Slender build (HP:0001533)2.22149824
71Increased variability in muscle fiber diameter (HP:0003557)2.20240293
72Metaphyseal cupping (HP:0003021)2.20175220
73Ulnar bowing (HP:0003031)2.19707660
74Abnormal tarsal ossification (HP:0008369)2.19694024
75Thoracolumbar scoliosis (HP:0002944)2.19317353
76Cerebral inclusion bodies (HP:0100314)2.14069966
77Aortic valve stenosis (HP:0001650)2.13986525
78Bowel diverticulosis (HP:0005222)2.13791860
79Shawl scrotum (HP:0000049)2.12133402
80Ectopia lentis (HP:0001083)2.09393903
81Abnormality of the middle phalanges of the toes (HP:0010183)2.08512293
82Hyperextensible skin (HP:0000974)2.08415395
83Barrel-shaped chest (HP:0001552)2.08330254
84Genu varum (HP:0002970)2.08259238
85Relative macrocephaly (HP:0004482)2.06829993
86Wide anterior fontanel (HP:0000260)2.06501477
87Aplasia involving bones of the extremities (HP:0009825)2.06353822
88Aplasia involving bones of the upper limbs (HP:0009823)2.06353822
89Aplasia of the phalanges of the hand (HP:0009802)2.06353822
90Stridor (HP:0010307)2.05827342
91Absent frontal sinuses (HP:0002688)2.05283733
92Abnormal vertebral ossification (HP:0100569)2.04351696
93Neoplasm of the heart (HP:0100544)2.03462027
94Wrist flexion contracture (HP:0001239)2.03164625
95Abnormality of the odontoid process (HP:0003310)2.01186919
96Mixed hearing impairment (HP:0000410)2.00680154
97Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00573473
98Broad ribs (HP:0000885)2.00113477
99Hypoplasia of the odontoid process (HP:0003311)1.99876034
100Flat acetabular roof (HP:0003180)1.99282556
101Supranuclear gaze palsy (HP:0000605)1.98938957
102Rhinitis (HP:0012384)1.98682410
103Abnormality of the pubic bones (HP:0003172)1.98166411
104Pulmonary artery stenosis (HP:0004415)1.97427641
105Buphthalmos (HP:0000557)1.95501874
106Morphological abnormality of the middle ear (HP:0008609)1.95329826
107Hip contracture (HP:0003273)1.95279087
108Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.94165815
109Abnormality of femoral epiphyses (HP:0006499)1.94165815
110Distal upper limb amyotrophy (HP:0007149)1.94089681
111Upper limb amyotrophy (HP:0009129)1.94089681
112Vertebral clefting (HP:0008428)1.93519676
113Spondylolisthesis (HP:0003302)1.92579114
114Round ear (HP:0100830)1.92471949
115Abnormality of the 2nd finger (HP:0004100)1.90821282
116Abnormality of the corticospinal tract (HP:0002492)1.89148714
117Anteriorly placed anus (HP:0001545)1.89128404
118Hyperacusis (HP:0010780)1.87481606
119Ulnar deviation of the wrist (HP:0003049)1.87349254
120Abnormality of the calcaneus (HP:0008364)1.86929286
121Premature skin wrinkling (HP:0100678)1.86548146
122Nuclear cataract (HP:0100018)1.85329783
123Mesomelia (HP:0003027)1.84950138
124Peripheral hypomyelination (HP:0007182)1.83478927
125Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83101862
126Blue sclerae (HP:0000592)1.83061449
127Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82833490
128Absent epiphyses (HP:0010577)1.82833490
129Humeroradial synostosis (HP:0003041)1.82389715
130Synostosis involving the elbow (HP:0003938)1.82389715
131Aneurysm (HP:0002617)1.82032347
132Nasal polyposis (HP:0100582)1.81714882
133Limited elbow extension (HP:0001377)1.81384503
134Disproportionate tall stature (HP:0001519)1.80966031
135Hypoplasia of the iris (HP:0007676)1.80643698
136Thin ribs (HP:0000883)1.80304289
137Platyspondyly (HP:0000926)1.79233158
138Hand muscle atrophy (HP:0009130)1.78892047
139Broad long bones (HP:0005622)1.77981132
140Short hallux (HP:0010109)1.77285034
141Mildly elevated creatine phosphokinase (HP:0008180)1.76910760
142Hypoventilation (HP:0002791)1.76680515
143Abnormality of the vitreous humor (HP:0004327)1.75517502
144Renovascular hypertension (HP:0100817)1.75374023
145Irregular vertebral endplates (HP:0003301)1.75339974
146Onion bulb formation (HP:0003383)1.75005836
147Fragile skin (HP:0001030)1.74465346
148Down-sloping shoulders (HP:0200021)1.73950592
149Joint laxity (HP:0001388)1.73622622
150Abnormality of the vertebral endplates (HP:0005106)1.73589135
151Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72701863
152Short 4th metacarpal (HP:0010044)1.72701863
153Abnormality of the nasal mucosa (HP:0000433)1.72261058
154Myelomeningocele (HP:0002475)1.72114970
155Abnormality of the epiphysis of the femoral head (HP:0010574)1.71550503
156Mitral valve prolapse (HP:0001634)1.69591193
157Abnormality of the femoral head (HP:0003368)1.69577222
158Abnormality of skeletal muscle fiber size (HP:0012084)1.69330045
159Congenital glaucoma (HP:0001087)1.69205337
160Increased connective tissue (HP:0009025)1.67511592
161Venous insufficiency (HP:0005293)1.65885186
162Difficulty climbing stairs (HP:0003551)1.64169837
163Long toe (HP:0010511)1.64006639
164Calcaneovalgus deformity (HP:0001848)1.62653542

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.47898113
2TRIB33.94322505
3DDR23.35903092
4BCR3.14085175
5OXSR12.94960317
6ICK2.82607225
7MET2.49949866
8EPHB12.43355063
9LIMK12.26729422
10SIK12.14263435
11WNK42.13039299
12CSNK1A1L2.09381548
13RIPK12.07888897
14EPHA42.04899168
15FGFR22.02400636
16PRPF4B2.02032747
17CDK192.00273988
18CSNK1G31.90431797
19PKN11.87995671
20EPHB21.87290459
21PKN21.76304547
22WNK11.65499439
23PBK1.59334593
24UHMK11.59177260
25TNIK1.58380776
26NEK61.56848649
27MAPK151.56824108
28CSNK1G21.55251985
29RPS6KA21.54273173
30ROCK21.53783463
31CSNK1G11.53452005
32ERN11.53172964
33SIK21.47163009
34MAP3K71.43931302
35NTRK11.43924150
36LATS11.40247406
37MARK11.37581069
38MYLK1.37536778
39DYRK1B1.36056939
40EPHA21.35601072
41STK381.32245149
42MAP2K31.27329996
43PAK61.26447248
44MAP2K41.25892314
45PRKD31.23226742
46EPHA31.20804349
47PAK31.20016493
48PNCK1.18945223
49MTOR1.18021328
50FGR1.16495806
51FLT31.14266607
52TYRO31.13101513
53PTK61.06125791
54CAMK2B1.03374023
55TRPM71.03024518
56FGFR41.02319784
57TTN1.01957412
58CLK11.01424752
59ERBB20.99220292
60CAMK2D0.98968803
61MAPK70.97350420
62CDK140.96479915
63RPS6KC10.94898970
64RPS6KL10.94898970
65MARK20.94813184
66SGK4940.94471704
67SGK2230.94471704
68MAP3K100.93831871
69PDGFRB0.93585425
70MAP3K40.93556055
71DYRK20.92244804
72MST1R0.91724995
73PRKCH0.91498798
74CASK0.90797779
75DYRK1A0.90209914
76BMX0.89662453
77CDK150.88102777
78MAP3K60.87606894
79PTK2B0.86425107
80EEF2K0.84776321
81MAP2K70.83991955
82CDK180.83935859
83CDK50.83300099
84CDK11A0.81513393
85PDGFRA0.80741369
86ZAP700.80669649
87NTRK30.80285723
88RPS6KA60.79086156
89ROCK10.78968448
90PRKD20.78859149
91TESK10.77416957
92FGFR10.77406001
93PINK10.74634934
94PRKD10.70623806
95DYRK30.69533962
96PHKG20.67691230
97PHKG10.67691230
98PTK20.67159505
99PAK20.67103683
100NEK90.64928105
101PLK20.64472873
102AKT30.60941776
103CAMK2A0.59298754
104ERBB40.58936823
105SGK20.58548496
106BRD40.57700733
107FER0.57272818
108PRKCE0.57220590
109DMPK0.54989574
110MAP2K60.54412130
111TNK20.53952670
112MAP3K20.53623164
113SGK30.51337501
114NTRK20.51190263
115CAMK1G0.50352231
116TAOK10.50018412
117CAMK2G0.48752881
118FYN0.48443176
119MAPK120.47361624
120NUAK10.47138290
121GSK3A0.45794008
122KSR10.45268800
123ILK0.44310634
124CAMKK10.44163959
125OBSCN0.44088014
126PRKG10.43542323
127CSNK1D0.43537456
128CDC42BPA0.43214571
129WNK30.42690867
130PAK10.42099850
131MAPK10.39978990
132SRC0.39862957
133MAPK80.39622354
134STK110.39296729
135DAPK20.38941823
136NME10.38148303
137PDPK10.37984463
138MOS0.37695548
139MKNK10.37618520
140PRKCQ0.37064086
141MAP3K30.37021371
142STK30.36663327
143INSR0.36544333
144ARAF0.36248110
145LATS20.35997313
146BLK0.35600556
147CSNK1A10.35457273
148ADRBK10.34102649
149MST40.34066021
150STK38L0.33634390
151RET0.33249920
152NEK20.32860539
153RPS6KA10.32348425
154INSRR0.31830902
155LRRK20.31045002

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.80871579
2* ECM-receptor interaction_Homo sapiens_hsa045123.33631204
3Steroid biosynthesis_Homo sapiens_hsa001003.12221567
4Axon guidance_Homo sapiens_hsa043602.83309804
5Protein digestion and absorption_Homo sapiens_hsa049742.46148708
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.41088089
7Other glycan degradation_Homo sapiens_hsa005112.39008979
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.30739915
9Hedgehog signaling pathway_Homo sapiens_hsa043402.15172805
10Basal cell carcinoma_Homo sapiens_hsa052172.08507271
11Fatty acid elongation_Homo sapiens_hsa000621.94815799
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89624431
13* Focal adhesion_Homo sapiens_hsa045101.76326571
14Ether lipid metabolism_Homo sapiens_hsa005651.73558256
15Sphingolipid metabolism_Homo sapiens_hsa006001.55975531
16Tight junction_Homo sapiens_hsa045301.54816643
17Hippo signaling pathway_Homo sapiens_hsa043901.49425360
18Renal cell carcinoma_Homo sapiens_hsa052111.45767190
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45261979
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38175942
21Wnt signaling pathway_Homo sapiens_hsa043101.33900845
22Long-term depression_Homo sapiens_hsa047301.30561990
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29567111
24VEGF signaling pathway_Homo sapiens_hsa043701.25860643
25Dilated cardiomyopathy_Homo sapiens_hsa054141.23176580
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22356282
27Cocaine addiction_Homo sapiens_hsa050301.21846158
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21813424
29Protein export_Homo sapiens_hsa030601.21732067
30Endometrial cancer_Homo sapiens_hsa052131.18852875
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17620397
32* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14108928
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13523637
34Circadian entrainment_Homo sapiens_hsa047131.12954088
35Glutamatergic synapse_Homo sapiens_hsa047241.12485548
36Vibrio cholerae infection_Homo sapiens_hsa051101.12249091
37ErbB signaling pathway_Homo sapiens_hsa040121.11529930
38Melanogenesis_Homo sapiens_hsa049161.11290552
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.10954767
40Sulfur metabolism_Homo sapiens_hsa009201.09167145
41Proteoglycans in cancer_Homo sapiens_hsa052051.08096373
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07947923
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07545522
44Serotonergic synapse_Homo sapiens_hsa047261.07241444
45Prolactin signaling pathway_Homo sapiens_hsa049171.03368726
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03274948
47Chronic myeloid leukemia_Homo sapiens_hsa052201.02695559
48TGF-beta signaling pathway_Homo sapiens_hsa043501.02383852
49Olfactory transduction_Homo sapiens_hsa047401.01895831
50Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00274371
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00066123
52Morphine addiction_Homo sapiens_hsa050320.98837943
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97885896
54Dorso-ventral axis formation_Homo sapiens_hsa043200.97711847
55GABAergic synapse_Homo sapiens_hsa047270.97441763
56Ras signaling pathway_Homo sapiens_hsa040140.97366860
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.96536080
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96507195
59Colorectal cancer_Homo sapiens_hsa052100.95307246
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.94217891
61Bladder cancer_Homo sapiens_hsa052190.94161845
62Ovarian steroidogenesis_Homo sapiens_hsa049130.92721792
63Gap junction_Homo sapiens_hsa045400.92231934
64mTOR signaling pathway_Homo sapiens_hsa041500.89222253
65ABC transporters_Homo sapiens_hsa020100.89037524
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87133543
67Amoebiasis_Homo sapiens_hsa051460.84822508
68Adherens junction_Homo sapiens_hsa045200.84505584
69Endocytosis_Homo sapiens_hsa041440.83371477
70cAMP signaling pathway_Homo sapiens_hsa040240.83257171
71Non-small cell lung cancer_Homo sapiens_hsa052230.83074900
72Dopaminergic synapse_Homo sapiens_hsa047280.79990397
73Notch signaling pathway_Homo sapiens_hsa043300.79077448
74Acute myeloid leukemia_Homo sapiens_hsa052210.76419572
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76377860
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75955908
77Prostate cancer_Homo sapiens_hsa052150.75699422
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.74684689
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.74411242
80Insulin signaling pathway_Homo sapiens_hsa049100.74265153
81Salivary secretion_Homo sapiens_hsa049700.73901351
82Cholinergic synapse_Homo sapiens_hsa047250.73752781
83Circadian rhythm_Homo sapiens_hsa047100.73441787
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73396952
85* Malaria_Homo sapiens_hsa051440.73155807
86Amphetamine addiction_Homo sapiens_hsa050310.72408237
87Cardiac muscle contraction_Homo sapiens_hsa042600.72266835
88AMPK signaling pathway_Homo sapiens_hsa041520.71700465
89MAPK signaling pathway_Homo sapiens_hsa040100.71594031
90Renin secretion_Homo sapiens_hsa049240.71573395
91Type II diabetes mellitus_Homo sapiens_hsa049300.70819457
92Rap1 signaling pathway_Homo sapiens_hsa040150.70100467
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69527207
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68981847
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67825721
96Pathways in cancer_Homo sapiens_hsa052000.67514262
97Small cell lung cancer_Homo sapiens_hsa052220.67376947
98Pancreatic cancer_Homo sapiens_hsa052120.67221484
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65945549
100MicroRNAs in cancer_Homo sapiens_hsa052060.65782931
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.65574806
102Lysine degradation_Homo sapiens_hsa003100.65559939
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65345955
104Oxytocin signaling pathway_Homo sapiens_hsa049210.65128082
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64748931
106Lysosome_Homo sapiens_hsa041420.64286656
107GnRH signaling pathway_Homo sapiens_hsa049120.63276036
108Estrogen signaling pathway_Homo sapiens_hsa049150.61823693
109Melanoma_Homo sapiens_hsa052180.61548023
110Linoleic acid metabolism_Homo sapiens_hsa005910.61155348
111FoxO signaling pathway_Homo sapiens_hsa040680.60229994
112Nicotine addiction_Homo sapiens_hsa050330.60065912
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59033044
114Insulin secretion_Homo sapiens_hsa049110.58271696
115Choline metabolism in cancer_Homo sapiens_hsa052310.57665604
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57653513
117Inositol phosphate metabolism_Homo sapiens_hsa005620.57479070
118Glioma_Homo sapiens_hsa052140.57068938
119Prion diseases_Homo sapiens_hsa050200.57002810
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.56945545
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56771051
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56671206
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56559991
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56238526
125Gastric acid secretion_Homo sapiens_hsa049710.56059580
126Bile secretion_Homo sapiens_hsa049760.54620252
127Arachidonic acid metabolism_Homo sapiens_hsa005900.54549535
128Mineral absorption_Homo sapiens_hsa049780.53925765
129Alcoholism_Homo sapiens_hsa050340.52036810
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51429073
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51107284
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50843512
133Arginine and proline metabolism_Homo sapiens_hsa003300.50401144
134Alzheimers disease_Homo sapiens_hsa050100.50257750
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49008156
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48986639
137Long-term potentiation_Homo sapiens_hsa047200.48860216
138Oxidative phosphorylation_Homo sapiens_hsa001900.48260301
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47499021

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